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Aliases for FBXO44 Gene

Aliases for FBXO44 Gene

  • F-Box Protein 44 2 3 5
  • F-Box/G-Domain Protein 3 3 4
  • F-Box Protein FBX30 3 4
  • Fbxo6a 3 4
  • Fbx30 3 4
  • Fbx44 3 4
  • FBX6A 3 4
  • FBG3 3 4
  • F-Box Gene 3 3

External Ids for FBXO44 Gene

Previous GeneCards Identifiers for FBXO44 Gene

  • GC01P011423
  • GC01P011650
  • GC01P011714
  • GC01P010868

Summaries for FBXO44 Gene

Entrez Gene Summary for FBXO44 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

GeneCards Summary for FBXO44 Gene

FBXO44 (F-Box Protein 44) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is FBXO27.

UniProtKB/Swiss-Prot for FBXO44 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO44 Gene

Genomics for FBXO44 Gene

Regulatory Elements for FBXO44 Gene

Promoters for FBXO44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO44 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO44 Gene

Chromosome:
1
Start:
11,654,375 bp from pter
End:
11,663,327 bp from pter
Size:
8,953 bases
Orientation:
Plus strand

Genomic View for FBXO44 Gene

Genes around FBXO44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO44 Gene

Proteins for FBXO44 Gene

  • Protein details for FBXO44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4M3-FBX44_HUMAN
    Recommended name:
    F-box only protein 44
    Protein Accession:
    Q9H4M3
    Secondary Accessions:
    • B3KNZ2
    • B7Z743
    • Q5TGX2
    • Q5TGX4
    • Q5TGX5
    • Q68DJ9
    • Q8WWY2

    Protein attributes for FBXO44 Gene

    Size:
    255 amino acids
    Molecular mass:
    29747 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
    Miscellaneous:
    • In contrast to other FBA domain containing proteins, FBXO44 demonstrates no significant binding to any of the 200 glycans tested.
    SequenceCaution:
    • Sequence=CAI20210.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20213.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBXO44 Gene

    Alternative splice isoforms for FBXO44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO44 Gene

Proteomics data for FBXO44 Gene at MOPED

Post-translational modifications for FBXO44 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for FBXO44 Gene

Domains & Families for FBXO44 Gene

Gene Families for FBXO44 Gene

Protein Domains for FBXO44 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4M3

UniProtKB/Swiss-Prot:

FBX44_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
  • Contains 1 FBA (F-box associated) domain.
genes like me logo Genes that share domains with FBXO44: view

Function for FBXO44 Gene

Molecular function for FBXO44 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXO44: view

Animal Models for FBXO44 Gene

MGI Knock Outs for FBXO44:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO44 Gene

Localization for FBXO44 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO44 Gene COMPARTMENTS Subcellular localization image for FBXO44 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO44 Gene

Pathways & Interactions for FBXO44 Gene

genes like me logo Genes that share pathways with FBXO44: view

Gene Ontology (GO) - Biological Process for FBXO44 Gene

None

No data available for SIGNOR curated interactions for FBXO44 Gene

Drugs & Compounds for FBXO44 Gene

No Compound Related Data Available

Transcripts for FBXO44 Gene

Unigene Clusters for FBXO44 Gene

F-box protein 44:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO44 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
SP1: -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6: -

Relevant External Links for FBXO44 Gene

GeneLoc Exon Structure for
FBXO44
ECgene alternative splicing isoforms for
FBXO44

Expression for FBXO44 Gene

mRNA expression in normal human tissues for FBXO44 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO44 Gene

This gene is overexpressed in Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for FBXO44 Gene

This gene is overexpressed in Frontal cortex (40.8), Salivary gland (13.0), Fetal Brain (8.0), and Prostate (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO44 Gene



SOURCE GeneReport for Unigene cluster for FBXO44 Gene Hs.556006

mRNA Expression by UniProt/SwissProt for FBXO44 Gene

Q9H4M3-FBX44_HUMAN
Tissue specificity: Abundantly expressed in brain and kidney. Expressed at lower levels in heart, spleen and liver.
genes like me logo Genes that share expression patterns with FBXO44: view

Protein tissue co-expression partners for FBXO44 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FBXO44 Gene

Orthologs for FBXO44 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO44 36
  • 100 (a)
OneToOne
FBXO44 35
  • 99.48 (n)
  • 99.61 (a)
cow
(Bos Taurus)
Mammalia FBXO44 35
  • 92.55 (n)
  • 98.04 (a)
FBXO44 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo44 16
Fbxo44 36
  • 96 (a)
OneToOne
Fbxo44 35
  • 90.46 (n)
  • 96.47 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxo44 35
  • 89.67 (n)
  • 96.08 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii fbxo44 36
  • 38 (a)
ManyToMany
si:dkey-147f3.4 36
  • 29 (a)
ManyToMany
si:dkey-147f3.4 36
  • 41 (a)
ManyToMany
si:dkey-147f3.8 36
  • 22 (a)
ManyToMany
si:rp71-1k13.6 36
  • 36 (a)
ManyToMany
zgc:100832 36
  • 43 (a)
ManyToMany
zgc:114081 36
  • 32 (a)
ManyToMany
zgc:114174 36
  • 33 (a)
ManyToMany
zgc:153722 36
  • 37 (a)
ManyToMany
zgc:173570 36
  • 40 (a)
ManyToMany
zgc:175088 36
  • 46 (a)
ManyToMany
Species with no ortholog for FBXO44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO44 Gene

ENSEMBL:
Gene Tree for FBXO44 (if available)
TreeFam:
Gene Tree for FBXO44 (if available)

Paralogs for FBXO44 Gene

Paralogs for FBXO44 Gene

(4) SIMAP similar genes for FBXO44 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXO44: view

Variants for FBXO44 Gene

Sequence variations from dbSNP and Humsavar for FBXO44 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2294640 -- 11,661,892(-) CACCC(A/G)ACCTG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs2294641 -- 11,661,797(-) AGCGA(A/G)AGACT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs2294642 -- 11,661,636(-) AAGAA(C/T)ACAGG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs3117063 -- 11,659,381(+) ctcaa(A/C)aaaaa intron-variant
rs3215522 -- 11,661,777(-) CAGAC(-/AG)GGGCA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO44 Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV Loss 17160897
dgv139n71 CNV Loss 21882294
nsv871014 CNV Gain 21882294
nsv871850 CNV Loss 21882294
nsv521468 CNV Loss 19592680

Variation tolerance for FBXO44 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO44 Gene

HapMap Linkage Disequilibrium report
FBXO44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO44 Gene

Disorders for FBXO44 Gene

Relevant External Links for FBXO44

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO44

No disorders were found for FBXO44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO44 Gene

Publications for FBXO44 Gene

  1. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 2 3 4 23 67
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for FBXO44 Gene

Sources for FBXO44 Gene

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