Aliases for FBXO43 Gene
Aliases for FBXO43 Gene
External Ids for FBXO43 Gene
- HGNC: 28521
- Entrez Gene: 286151
- Ensembl: ENSG00000156509
- OMIM: 609110
- UniProtKB: Q4G163
Previous GeneCards Identifiers for FBXO43 Gene
- GC08M101103
- GC08M101214
- GC08M096348
- GC08M101145
Summaries for FBXO43 Gene
-
Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO43 Gene
FBXO43 (F-Box Protein 43) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is FBXO5.
UniProtKB/Swiss-Prot for FBXO43 Gene
-
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO43 Gene
Genomics for FBXO43 Gene
Regulatory Elements for FBXO43 Gene
Enhancers for FBXO43 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO43 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXO43 Gene
- Chromosome:
- 8
- Start:
- 100,133,360 bp from pter
- End:
- 100,150,569 bp from pter
- Size:
- 17,210 bases
- Orientation:
- Minus strand
Genomic View for FBXO43 Gene
Genes around FBXO43 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q22.2 by Ensembl
- 8q22.2 by Entrez Gene
- 8q22.2 by HGNC
FBXO43 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO43 Gene
Proteins for FBXO43 Gene
-
Protein details for FBXO43 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4G163-FBX43_HUMAN
- Recommended name:
- F-box only protein 43
- Protein Accession:
- Q4G163
Protein attributes for FBXO43 Gene
- Size:
- 708 amino acids
- Molecular mass:
- 78402 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex. May interact with CDC20 (By similarity).
Protein Expression for FBXO43 Gene
Post-translational modifications for FBXO43 Gene
- Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.
- Ubiquitinated in response to calcium, which promotes proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FBXO43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXO43
Protein Products
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- antibodies-online Proteins for FBXO43: See all 4
- Search antibodies-online for peptides
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Assay Products
- antibodies-online Kits for FBXO43: See all 15
No data available for DME Specific Peptides for FBXO43 Gene
Domains & Families for FBXO43 Gene
Gene Families for FBXO43 Gene
- HGNC:
Protein Domains for FBXO43 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO43 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO43 Gene
Function for FBXO43 Gene
Molecular function for FBXO43 Gene
- UniProtKB/Swiss-Prot Function:
- Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FBXO43 Gene
- GenomeRNAi human phenotypes for FBXO43:
Animal Model Products
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-
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-
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- Search ViGene Biosciences for FBXO43
CRISPR Products
-
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-
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miRNA for FBXO43 Gene
- miRTarBase miRNAs that target FBXO43
-
- mmu-mir-1946a (MIRT590029)
- mmu-mir-546 (MIRT590030)
- mmu-mir-709 (MIRT590031)
- mmu-mir-1935 (MIRT590032)
- mmu-mir-298-5p (MIRT590033)
- mmu-mir-876-5p (MIRT590034)
- mmu-mir-5135 (MIRT590035)
- mmu-mir-804 (MIRT590036)
- mmu-mir-3089-5p (MIRT590037)
- mmu-mir-1195 (MIRT590038)
- mmu-mir-665-3p (MIRT590039)
- mmu-mir-706 (MIRT599020)
miRNA Products
- Search ViGene Biosciences for FBXO43
Inhibitory RNA Products
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-
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-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO43 Gene
Localization for FBXO43 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO43 Gene
Pathways & Interactions for FBXO43 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Oocyte meiosis |
.41
|
|
Pathways by source for FBXO43 Gene
1 KEGG pathway for FBXO43 Gene
UniProtKB/Swiss-Prot Q4G163-FBX43_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXO43 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007088 | regulation of mitotic nuclear division | IBA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0045835 | negative regulation of meiotic nuclear division | IBA | -- |
| GO:0051321 | meiotic cell cycle | IEA | -- |
| GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | IBA | -- |
No data available for SIGNOR curated interactions for FBXO43 Gene
Drugs & Compounds for FBXO43 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for FBXO43 Gene
mRNA/cDNA for FBXO43 Gene
- (7) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO43
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO43
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miRNA Products
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Inhibitory RNA Products
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-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | - |
Expression for FBXO43 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
mRNA differential expression in normal tissues according to GTEx for FBXO43 Gene
This gene is overexpressed in Testis (x19.8).
This gene is overexpressed in Heart (63.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO43 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXO43 Gene:
FBXO43SOURCE GeneReport for Unigene cluster for FBXO43 Gene:
Hs.339577Primer Products
-
OriGene qPCR primer pairs for FBXO43
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO43 Gene
Orthologs for FBXO43 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO43 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO43 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO43 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo43 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo43 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO43 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO43 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO43 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO43 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo43 34 |
|
||
| Str.3899 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397879 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo43 35 34 |
|
OneToOne |
- Species where no ortholog for FBXO43 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO43 Gene
Variants for FBXO43 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015466 | -- | 100,137,133(+) | CTCAC(A/G)CTGCA | intron-variant | |
| rs1000042195 | -- | 100,142,221(+) | GCAGC(C/T)TATAC | intron-variant | |
| rs1000088447 | -- | 100,137,378(+) | TGATG(C/T)TATGT | intron-variant | |
| rs1000444093 | -- | 100,138,359(+) | CTTCT(C/T)ACGGA | intron-variant | |
| rs1000580474 | -- | 100,145,440(+) | GGCGG(A/G)TGGGT | intron-variant, nc-transcript-variant, utr-variant-5-prime |
Residual Variation Intolerance Score:
30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.48;
71.71% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO43 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO43
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO43 Gene
Disorders for FBXO43 Gene
Relevant External Links for FBXO43
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXO43
No disorders were found for FBXO43 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO43 Gene
Publications for FBXO43 Gene
- CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. (PMID: 16407128) Hansen D.V. … Jackson P.K. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 64
- A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. (PMID: 15753281) Tung J.J. … Jackson P.K. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 64
- Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4 64
- The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. (PMID: 25161877) Shoji S. … Yokoyama S. (FEBS Open Bio 2014) 3 64
- Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PMID: 18550795) Tang W. … Kornbluth S. (Mol. Biol. Cell 2008) 3 64
Products for FBXO43 Gene
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO43 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer