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Aliases for FBXO43 Gene

Aliases for FBXO43 Gene

  • F-Box Protein 43 2 3 5
  • Endogenous Meiotic Inhibitor 2 3 4
  • EMI2 3 4
  • Early Mitotic Inhibitor 2 3
  • F-Box Only Protein 43 3
  • FBX43 3
  • ERP1 3

External Ids for FBXO43 Gene

Previous GeneCards Identifiers for FBXO43 Gene

  • GC08M101103
  • GC08M101214
  • GC08M096348
  • GC08M101145

Summaries for FBXO43 Gene

Entrez Gene Summary for FBXO43 Gene

  • Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO43 Gene

FBXO43 (F-Box Protein 43) is a Protein Coding gene. Among its related pathways are Oocyte meiosis. An important paralog of this gene is FBXO5.

UniProtKB/Swiss-Prot for FBXO43 Gene

  • Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO43 Gene

Genomics for FBXO43 Gene

Regulatory Elements for FBXO43 Gene

Enhancers for FBXO43 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F100237 1.1 Ensembl ENCODE 16.1 -87.9 -87906 1.8 ATF1 JUN TAL1 HIC1 ZNF316 GATA3 CTBP1 NCOR1 SCRT2 TRIM24 FBXO43 POLR2K ENSG00000253666 SPAG1 LOC105375668 LOC105375669
GH08F100525 1.3 Ensembl ENCODE 10.9 -377.4 -377358 4.5 HDGF PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A YY1 ZNF143 FOS ANKRD46 FBXO43 POLR2K ENSG00000253666 ENSG00000202310 SPAG1 ENSG00000253217 RNF19A RGS22 LOC105375674
GH08F100540 1 Ensembl ENCODE 12.4 -390.4 -390432 0.4 ELF3 CTCF ZNF384 CEBPG RAD21 ZBTB40 RFX5 CBX5 SMC3 MIXL1 FBXO43 POLR2K ENSG00000202310 SPAG1 RGS22 GC08M100535 ENSG00000254364
GH08F100218 0.9 Ensembl ENCODE 11.1 -68.3 -68266 1.1 PKNOX1 MTA2 MAFG JUNB ZEB2 TBX21 ZNF316 IKZF1 NBN NFE2 SPAG1 ENSG00000202310 POLR2K FBXO43 RGS22 LOC105375669 ENSG00000199667
GH08F100567 0.7 ENCODE 10.1 -417.0 -416990 1.0 TAL1 MNT RAD21 NR2F2 YY1 ARID1B GATA3 SMARCA4 ATF3 PBX2 RNU4-83P LOC105375671 SNX31 FBXO43 POLR2K MIR7705 PABPC1 RGS22 ANKRD46
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO43 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001397539 -32 2400 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for FBXO43 Gene

Chromosome:
8
Start:
100,133,360 bp from pter
End:
100,150,569 bp from pter
Size:
17,210 bases
Orientation:
Minus strand

Genomic View for FBXO43 Gene

Genes around FBXO43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO43 Gene

Proteins for FBXO43 Gene

  • Protein details for FBXO43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G163-FBX43_HUMAN
    Recommended name:
    F-box only protein 43
    Protein Accession:
    Q4G163

    Protein attributes for FBXO43 Gene

    Size:
    708 amino acids
    Molecular mass:
    78402 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. May interact with CDC20 (By similarity).

neXtProt entry for FBXO43 Gene

Post-translational modifications for FBXO43 Gene

  • Phosphorylated on Ser-76, Thr-234 and Ser-334 in response to calcium, which is a prerequisite for ubiquitination and proteasomal degradation.
  • Ubiquitinated in response to calcium, which promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO43 Gene

No data available for DME Specific Peptides for FBXO43 Gene

Domains & Families for FBXO43 Gene

Gene Families for FBXO43 Gene

Protein Domains for FBXO43 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G163

UniProtKB/Swiss-Prot:

FBX43_HUMAN :
  • Contains 1 F-box domain.
  • Contains 1 IBR-type zinc finger.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 1 IBR-type zinc finger.
genes like me logo Genes that share domains with FBXO43: view

Function for FBXO43 Gene

Molecular function for FBXO43 Gene

UniProtKB/Swiss-Prot Function:
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable).

Gene Ontology (GO) - Molecular Function for FBXO43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FBXO43: view

Phenotypes for FBXO43 Gene

GenomeRNAi human phenotypes for FBXO43:
genes like me logo Genes that share phenotypes with FBXO43: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO43 Gene

Localization for FBXO43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO43 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for FBXO43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FBXO43: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO43 Gene

Pathways & Interactions for FBXO43 Gene

SuperPathways for FBXO43 Gene

SuperPathway Contained pathways
1 Oocyte meiosis
genes like me logo Genes that share pathways with FBXO43: view

Pathways by source for FBXO43 Gene

1 KEGG pathway for FBXO43 Gene

UniProtKB/Swiss-Prot Q4G163-FBX43_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for FBXO43 Gene

Gene Ontology (GO) - Biological Process for FBXO43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007088 regulation of mitotic nuclear division IBA --
GO:0016567 protein ubiquitination IEA --
GO:0045835 negative regulation of meiotic nuclear division IBA --
GO:0051321 meiotic cell cycle IEA --
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle IBA --
genes like me logo Genes that share ontologies with FBXO43: view

No data available for SIGNOR curated interactions for FBXO43 Gene

Drugs & Compounds for FBXO43 Gene

(1) Drugs for FBXO43 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with FBXO43: view

Transcripts for FBXO43 Gene

Unigene Clusters for FBXO43 Gene

F-box protein 43:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO43 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for FBXO43 Gene

GeneLoc Exon Structure for
FBXO43
ECgene alternative splicing isoforms for
FBXO43

Expression for FBXO43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO43 Gene

This gene is overexpressed in Testis (x19.8).

Protein differential expression in normal tissues from HIPED for FBXO43 Gene

This gene is overexpressed in Heart (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO43 Gene



Protein tissue co-expression partners for FBXO43 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO43 Gene:

FBXO43

SOURCE GeneReport for Unigene cluster for FBXO43 Gene:

Hs.339577
genes like me logo Genes that share expression patterns with FBXO43: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXO43 Gene

Orthologs for FBXO43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO43 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia FBXO43 34 35
  • 86.96 (n)
cow
(Bos Taurus)
Mammalia FBXO43 34 35
  • 86.64 (n)
mouse
(Mus musculus)
Mammalia Fbxo43 34 16 35
  • 76.76 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo43 34
  • 75.11 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO43 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO43 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO43 34 35
  • 61.05 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO43 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo43 34
  • 58.21 (n)
Str.3899 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397879 34
zebrafish
(Danio rerio)
Actinopterygii fbxo43 34 35
  • 46.57 (n)
Species where no ortholog for FBXO43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO43 Gene

ENSEMBL:
Gene Tree for FBXO43 (if available)
TreeFam:
Gene Tree for FBXO43 (if available)

Paralogs for FBXO43 Gene

Paralogs for FBXO43 Gene

genes like me logo Genes that share paralogs with FBXO43: view

Variants for FBXO43 Gene

Sequence variations from dbSNP and Humsavar for FBXO43 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10579219 -- 100,148,244(+) AGACT(-/ATATC)ATATC intron-variant
rs111841074 -- 100,148,754(+) CACTA(A/G)TTTCA intron-variant, upstream-variant-2KB
rs112471774 -- 100,133,342(+) AATTA(C/T)AGAAT downstream-variant-500B
rs112671573 -- 100,145,638(+) GTCCC(C/G)CCGCC intron-variant, nc-transcript-variant, utr-variant-5-prime
rs112728485 -- 100,141,289(+) CTTCA(A/G)GTGAA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FBXO43 Gene

Variant ID Type Subtype PubMed ID
nsv611814 CNV loss 21841781

Variation tolerance for FBXO43 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.48; 71.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO43 Gene

Disorders for FBXO43 Gene

Relevant External Links for FBXO43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO43

No disorders were found for FBXO43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO43 Gene

Publications for FBXO43 Gene

  1. CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. (PMID: 16407128) Hansen D.V. … Jackson P.K. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 64
  2. A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. (PMID: 15753281) Tung J.J. … Jackson P.K. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 64
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4 64
  4. The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation. (PMID: 25161877) Shoji S. … Yokoyama S. (FEBS Open Bio 2014) 3 64
  5. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PMID: 18550795) Tang W. … Kornbluth S. (Mol. Biol. Cell 2008) 3 64

Products for FBXO43 Gene

Sources for FBXO43 Gene

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