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Aliases for FBXO42 Gene

Aliases for FBXO42 Gene

  • F-Box Protein 42 2 3
  • Fbx42 3 4 6
  • Just One F-Box And Kelch Domain-Containing Protein 3 4
  • KIAA1332 4 6
  • JFK 3 4
  • F-Box Only Protein 42 3

External Ids for FBXO42 Gene

Previous GeneCards Identifiers for FBXO42 Gene

  • GC01M015956
  • GC01M016321
  • GC01M016445
  • GC01M016575
  • GC01M016577
  • GC01M015093
  • GC01M016580
  • GC01M016582
  • GC01M016584
  • GC01M016593
  • GC01M016603
  • GC01M016612
  • GC01M016620

Summaries for FBXO42 Gene

Entrez Gene Summary for FBXO42 Gene

  • Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

GeneCards Summary for FBXO42 Gene

FBXO42 (F-Box Protein 42) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO42 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO42 Gene

Genomics for FBXO42 Gene

Regulatory Elements for FBXO42 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO42 Gene

16,246,839 bp from pter
16,352,454 bp from pter
105,616 bases
Minus strand

Genomic View for FBXO42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO42 Gene

Proteins for FBXO42 Gene

  • Protein details for FBXO42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 42
    Protein Accession:
    Secondary Accessions:
    • B3KP30
    • Q5TEU8
    • Q86XI0
    • Q8N3N4
    • Q8N5F8
    • Q9BRM0
    • Q9P2L4

    Protein attributes for FBXO42 Gene

    717 amino acids
    Molecular mass:
    77839 Da
    Quaternary structure:
    • Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.
    • Sequence=CAI22561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FBXO42 Gene

Proteomics data for FBXO42 Gene at MOPED

Post-translational modifications for FBXO42 Gene

  • Ubiquitination at Lys564
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO42 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXO42

No data available for DME Specific Peptides for FBXO42 Gene

Domains for FBXO42 Gene

Gene Families for FBXO42 Gene

Protein Domains for FBXO42 Gene


Suggested Antigen Peptide Sequences for FBXO42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 4 Kelch repeats.
  • Contains 1 F-box domain.
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with FBXO42: view

Function for FBXO42 Gene

Molecular function for FBXO42 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Gene Ontology (GO) - Molecular Function for FBXO42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXO42: view

Animal Model Products

miRNA for FBXO42 Gene

miRTarBase miRNAs that target FBXO42

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO42 Gene

Localization for FBXO42 Gene

Subcellular locations from

Jensen Localization Image for FBXO42 Gene COMPARTMENTS Subcellular localization image for FBXO42 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO42 Gene

Pathways for FBXO42 Gene

SuperPathways for FBXO42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO42 Gene


No data available for Pathways by source for FBXO42 Gene

Transcripts for FBXO42 Gene

Unigene Clusters for FBXO42 Gene

F-box protein 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - -
SP10: - -
SP11: - - -
SP12: - -

ExUns: 11b ^ 12 ^ 13a · 13b

Relevant External Links for FBXO42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO42 Gene

mRNA expression in normal human tissues for FBXO42 Gene

Protein differential expression in normal tissues for FBXO42 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.1), Fetal Brain (16.0), and Placenta (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO42 Gene

SOURCE GeneReport for Unigene cluster for FBXO42 Gene Hs.522384

genes like me logo Genes that share expressions with FBXO42: view

Expression partners for FBXO42 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO42 Gene

Orthologs for FBXO42 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO42 35
  • 87.59 (n)
  • 95.12 (a)
FBXO42 36
  • 95 (a)
(Canis familiaris)
Mammalia FBXO42 35
  • 93.49 (n)
  • 97.07 (a)
FBXO42 36
  • 97 (a)
(Mus musculus)
Mammalia Fbxo42 35
  • 88.8 (n)
  • 95.4 (a)
Fbxo42 16
Fbxo42 36
  • 95 (a)
(Pan troglodytes)
Mammalia FBXO42 35
  • 99.81 (n)
  • 99.86 (a)
FBXO42 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo42 35
  • 91.56 (n)
  • 97.73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
-- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO42 36
  • 89 (a)
(Gallus gallus)
Aves FBXO42 35
  • 80.35 (n)
  • 91.62 (a)
FBXO42 36
  • 84 (a)
(Anolis carolinensis)
Reptilia FBXO42 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo42 35
  • 69.68 (n)
  • 77.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5343 35
(Danio rerio)
Actinopterygii Dr.24223 35
fbxo42 35
  • 69.06 (n)
  • 80.14 (a)
fbxo42 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6758 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y50D7A.1 36
  • 21 (a)
Species with no ortholog for FBXO42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO42 Gene

Gene Tree for FBXO42 (if available)
Gene Tree for FBXO42 (if available)

Paralogs for FBXO42 Gene

No data available for Paralogs for FBXO42 Gene

Variants for FBXO42 Gene

Sequence variations from dbSNP and Humsavar for FBXO42 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs58125011 -- 16,342,582(+) AAAAA(-/A)GTTAT intron-variant
rs58022719 -- 16,323,278(+) CTGGG(C/T)GTGGT intron-variant
rs58017298 -- 16,270,716(+) AAGAA(-/GAA)AAGAT intron-variant
rs57827739 -- 16,271,299(+) TGTGT(-/GTGT)TGGCA intron-variant
rs57703992 -- 16,350,545(+) AACAT(-/C)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO42 Gene

Variant ID Type Subtype PubMed ID
dgv174n71 CNV Loss 21882294
nsv833869 CNV Loss 17160897
nsv870978 CNV Loss 21882294
nsv3520 CNV Insertion 18451855
esv1036042 CNV Insertion 17803354
esv2618916 CNV Deletion 19546169
esv2667137 CNV Deletion 23128226

Relevant External Links for FBXO42 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO42 Gene

Disorders for FBXO42 Gene

No disorders were found for FBXO42 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FBXO42 Gene

Publications for FBXO42 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. (PMID: 19509332) Sun L. … Shang Y. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for FBXO42 Gene

Sources for FBXO42 Gene

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