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Aliases for FBXO42 Gene

Aliases for FBXO42 Gene

  • F-Box Protein 42 2 3 5
  • Just One F-Box And Kelch Domain-Containing Protein 3 4
  • Fbx42 3 4
  • JFK 3 4
  • F-Box Only Protein 42 3
  • KIAA1332 4

External Ids for FBXO42 Gene

Previous GeneCards Identifiers for FBXO42 Gene

  • GC01M015956
  • GC01M016321
  • GC01M016445
  • GC01M016575
  • GC01M016577
  • GC01M015093
  • GC01M016580
  • GC01M016582
  • GC01M016584
  • GC01M016593
  • GC01M016603
  • GC01M016612
  • GC01M016620

Summaries for FBXO42 Gene

Entrez Gene Summary for FBXO42 Gene

  • Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

GeneCards Summary for FBXO42 Gene

FBXO42 (F-Box Protein 42) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO42 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO42 Gene

Genomics for FBXO42 Gene

Regulatory Elements for FBXO42 Gene

Enhancers for FBXO42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F015882 1.8 FANTOM5 Ensembl ENCODE 19.9 +467.2 467179 5.4 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 DEK SP3 SPEN ENSG00000237938 EIF1AXP1 FBXO42 RPL22P3 RPS16P1 HSPB7 FLJ37453 ENSG00000224621 LINC01772
GH01F016348 1.5 FANTOM5 ENCODE 20.9 +1.5 1520 5.5 CREB3L1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D SSRP1 GLIS1 ENSG00000237938 FBXO42 RPL22P3 ZBTB17 SPEN ARHGEF19 MFAP2 ANO7L1 RPS16P1 ENSG00000224621
GH01F016900 1.1 Ensembl ENCODE 18.8 -548.7 -548710 1.2 ZNF493 ZFP64 RAD21 ZNF354C SCRT2 ZNF680 SP3 ZBTB11 TSHZ1 REST RPL22P3 LINC01772 MFAP2 FBXO42 EIF1AXP1 ENSG00000224621 LOC105376805 CROCC ENSG00000272426 RNU1-2
GH01F016366 1.2 ENCODE 16.5 -15.5 -15492 3.0 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MFAP2 RPL22P3 ENSG00000237938 RSG1 ENSG00000224621 FAM231A SPEN RPS16P1 FBLIM1 ARHGEF19
GH01F016142 1.8 FANTOM5 Ensembl ENCODE 10.8 +200.8 200831 17.5 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC MEF2D GLIS1 SPEN ENSG00000237938 EPHA2 FBXO42 RPL22P3 ARHGEF19 FBLIM1 FAM131C LOC101927479 GC01P016103
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO42 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001517757 791 2601 CREB3L1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF143

Genomic Location for FBXO42 Gene

16,246,839 bp from pter
16,352,491 bp from pter
105,653 bases
Minus strand

Genomic View for FBXO42 Gene

Genes around FBXO42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO42 Gene

Proteins for FBXO42 Gene

  • Protein details for FBXO42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 42
    Protein Accession:
    Secondary Accessions:
    • B3KP30
    • Q5TEU8
    • Q86XI0
    • Q8N3N4
    • Q8N5F8
    • Q9BRM0
    • Q9P2L4

    Protein attributes for FBXO42 Gene

    717 amino acids
    Molecular mass:
    77839 Da
    Quaternary structure:
    • Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.
    • Sequence=CAI22561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FBXO42 Gene

Post-translational modifications for FBXO42 Gene

  • Ubiquitination at Lys 564
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO42 Gene

No data available for DME Specific Peptides for FBXO42 Gene

Domains & Families for FBXO42 Gene

Gene Families for FBXO42 Gene

Protein Domains for FBXO42 Gene

Suggested Antigen Peptide Sequences for FBXO42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 4 Kelch repeats.
  • Contains 1 F-box domain.
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with FBXO42: view

Function for FBXO42 Gene

Molecular function for FBXO42 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Gene Ontology (GO) - Molecular Function for FBXO42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25609649
genes like me logo Genes that share ontologies with FBXO42: view
genes like me logo Genes that share phenotypes with FBXO42: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO42 Gene

Localization for FBXO42 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO42 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO42 Gene

Pathways & Interactions for FBXO42 Gene

SuperPathways for FBXO42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO42 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO42 Gene

Transcripts for FBXO42 Gene

Unigene Clusters for FBXO42 Gene

F-box protein 42:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - -
SP10: - -
SP11: - - -
SP12: - -

ExUns: 11b ^ 12 ^ 13a · 13b

Relevant External Links for FBXO42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO42 Gene

Protein differential expression in normal tissues from HIPED for FBXO42 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.1), Fetal Brain (16.0), and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO42 Gene

Protein tissue co-expression partners for FBXO42 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO42 Gene:


SOURCE GeneReport for Unigene cluster for FBXO42 Gene:

genes like me logo Genes that share expression patterns with FBXO42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO42 Gene

Orthologs for FBXO42 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO42 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO42 34 35
  • 99.81 (n)
(Canis familiaris)
Mammalia FBXO42 34 35
  • 93.49 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
-- 35
  • 88 (a)
(Rattus norvegicus)
Mammalia Fbxo42 34
  • 91.56 (n)
(Ornithorhynchus anatinus)
Mammalia FBXO42 35
  • 89 (a)
(Mus musculus)
Mammalia Fbxo42 34 16 35
  • 88.8 (n)
(Bos Taurus)
Mammalia FBXO42 34 35
  • 87.59 (n)
(Gallus gallus)
Aves FBXO42 34 35
  • 80.35 (n)
(Anolis carolinensis)
Reptilia FBXO42 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo42 34
  • 69.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5343 34
(Danio rerio)
Actinopterygii fbxo42 34 35
  • 69.06 (n)
Dr.24223 34
fruit fly
(Drosophila melanogaster)
Insecta CG6758 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea Y50D7A.1 35
  • 21 (a)
Species where no ortholog for FBXO42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO42 Gene

Gene Tree for FBXO42 (if available)
Gene Tree for FBXO42 (if available)

Paralogs for FBXO42 Gene

No data available for Paralogs for FBXO42 Gene

Variants for FBXO42 Gene

Sequence variations from dbSNP and Humsavar for FBXO42 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002703 -- 16,253,378(+) CATGA(A/C)TGTCA intron-variant
rs1007150 -- 16,294,688(+) TAACC(C/T)ATCCT intron-variant
rs1008529 -- 16,256,191(-) ACCGC(C/T)GTTTC intron-variant
rs10465914 -- 16,328,179(+) ttttt(A/T)aaaaa intron-variant
rs10489597 -- 16,296,051(-) CTTCT(C/G)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO42 Gene

Variant ID Type Subtype PubMed ID
nsv947414 CNV duplication 23825009
nsv833869 CNV loss 17160897
nsv545642 CNV loss 21841781
nsv545641 CNV loss 21841781
nsv3520 CNV insertion 18451855
nsv1113081 CNV deletion 24896259
esv3585336 CNV loss 21293372
esv3585334 CNV gain 21293372
esv3577750 CNV loss 25503493
esv2667137 CNV deletion 23128226
esv2618916 CNV deletion 19546169
esv1036042 CNV insertion 17803354
dgv18e212 CNV gain 25503493

Variation tolerance for FBXO42 Gene

Residual Variation Intolerance Score: 5.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO42 Gene

Disorders for FBXO42 Gene

Relevant External Links for FBXO42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO42 Gene

Publications for FBXO42 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. (PMID: 19509332) Sun L. … Shang Y. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FBXO42 Gene

Sources for FBXO42 Gene

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