FBXO42 Gene
protein-coding GIFtS: 43
GCID: GC01M016603
|
|
F-box protein 42
| |
Aliases
for FBXO42 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box Protein 421 2 | | JFK2 3 | | KIAA13321 3 5 | | FBX423 5 | | Fbx421 2 | | F-Box Only Protein 422 | | Just One F-Box And Kelch Domain-Containing Protein2 3 | | |
Export aliases for FBXO42 gene to outside databasesPrevious GC identifers: GC01M015956 GC01M016321 GC01M016445 GC01M016575 GC01M016577 GC01M015093 GC01M016580 GC01M016582 GC01M016584 GC01M016593 |
Summaries
for FBXO42 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXO42:
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Dec 2010)
UniProtKB/Swiss-Prot: FBX42_HUMAN, Q6P3S6Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Specifically recognizes p53/TP53, promoting its ubiquitination and degradation
|
Genomic Views
for FBXO42 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXO42 gene promoter:
STAT1 AML1a STAT1beta STAT1alpha GATA-1 CREB MZF-1 POU2F1 POU2F1a ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO42
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO42 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.23-p36.11 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.23-p36.11FBXO42 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M016603: view genomic region
(about GC identifiers)
Start:
|
16,573,334 bp from pter |
End:
|
16,678,949 bp from pter |
Size:
|
105,616 bases |
Orientation:
|
minus strand |
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Proteins
for FBXO42 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBX42_HUMAN, Q6P3S6 (See
protein sequence)Recommended Name: F-box only protein 42 Size: 717 amino acids; 77839 Da
Subunit: Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) withp53/TP53; interaction is direct
Sequence caution: Sequence=CAI22561.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KP30 Q5TEU8 Q86XI0 Q8N3N4 Q8N5F8 Q9BRM0 Q9P2L4Explore the universe of human proteins at neXtProt for FBXO42: NX_Q6P3S6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P3S6
FBXO42 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061867.1
ENSEMBL proteins: ENSP00000364742 ENSP00000415663 ENSP00000412416
Human Recombinant Protein Products for FBXO42:
FBXO42 Antibody Products:
Assay Products for FBXO42: |
Protein
Domains /
Families
for FBXO42 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO42 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P3S6ProtoNet protein and cluster: Q6P3S6 1 Blocks protein family: IPB011498 Kelch
UniProtKB/Swiss-Prot: FBX42_HUMAN, Q6P3S6Similarity: Contains 1 F-box domainSimilarity: Contains 4 Kelch repeats |
Function
for FBXO42 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FBX42_HUMAN, Q6P3S6Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Specifically recognizes p53/TP53, promoting its ubiquitination and degradationAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO42 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO42 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXO42 (NM_018994) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO42 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO42 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO42 |
|
Pathways & Interactions
for FBXO42 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO42
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for FBXO42 (Q6P3S63 ENSP000003647424) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for FBXO42 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXO42
Search CenterWatch for drugs/clinical trials and news about FBXO42 / FBX42
|
Transcripts
for FBXO42 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXO42 gene: NM_018994.1 Unigene Cluster for FBXO42: F-box protein 42 Hs.522384 [show with all ESTs]Unigene Representative Sequence: AB0377534 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375592(uc001ayf.3 uc001ayg.3) ENST00000456164 ENST00000444116
ENST00000478089(uc001ayh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO42 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO42 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXO42 (NM_018994) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO42 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO42 |
Additional cDNA sequence: AB037753.1 AK025059.1 AK055598.1 AK310671.1 AL050213.1 AL833207.1 AL833874.1 BC006174.1 BC032439.1 BC043410.1 BC047296.1 BC063864.1 13 DOTS entries: DT.95150146 DT.410824 DT.97842205 DT.121345546 DT.121345557 DT.121345565 DT.91831961 DT.91975189 DT.95329367 DT.100698532 DT.121345428 DT.121345476 DT.95105497 24/153 AceView cDNA sequences (see all 153): BM551440 BC006174 CR615859 AB037753 AA084471 Z41965 AI917214 BQ709415 BP429334 BI908071 BC032439 BI757208 BC063864 AI129395 BX095277 BQ636922 AA344224 AI554246 AI290050 AI220199 CR602597 AA257075 AA322030 BC047296
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO42 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11b | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for FBXO42
|
Expression
for FBXO42 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FBXO42 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO42
SOURCE GeneReport for Unigene cluster: Hs.522384
SABiosciences Custom PCR Arrays for FBXO42
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO42
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO42 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO42 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO42 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO42 |
Orthologs
for FBXO42 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXO42 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for FBXO42 (if available)
TreeFam Gene Tree for FBXO42 (if available) |
Paralogs
for FBXO42 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FBXO42 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO42 (16573334 - 16678949 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBXO42: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO42 |
|
Disorders
/ Diseases
for FBXO42 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FBXO42 for disorders About MalaCards
FBXO42 for disorders About GeneDecksing
OMIM gene information: 609109
OMIM disorders: --
Export disorders for FBXO42 gene to outside databases
|
Publications
for FBXO42 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO42 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with FBXO42) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. (PubMed id 19509332)1, 2 Sun L.... Shang Y. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization. (PubMed id 21127074)1 Sun L....Shang Y. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for FBXO42 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXO42 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO42 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FBXO42 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for FBXO42 gene:
Search GeneIP for patents involving FBXO42
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXO42 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for FBXO42 | | OriGene Custom Protein Services for FBXO42 | | | OriGene Custom Immunoassay Development | | |
| |
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| |
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| | | | Search Tocris compounds for FBXO42 |
| |  |  |  |  | | | | |
 |
 |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO42 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO42 |
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