Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXO42 Gene

protein-coding   GIFtS: 49
GCID: GC01M016620

F-Box Protein 42

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box Protein 421 2     KIAA13323 5
Just One F-Box And Kelch Domain-Containing Protein2 3     Fbx422
JFK2 3     F-Box Only Protein 422
FBX423 5     

External Ids:    HGNC: 292491   Entrez Gene: 544552   Ensembl: ENSG000000376377   OMIM: 6091095   UniProtKB: Q6P3S63   

Export aliases for FBXO42 gene to outside databases

Previous GC identifers: GC01M015956 GC01M016321 GC01M016445 GC01M016575 GC01M016577 GC01M015093 GC01M016580 GC01M016582 GC01M016584 GC01M016593 GC01M016603 GC01M016612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXO42 Gene:
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act
as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Dec 2010)

GeneCards Summary for FBXO42 Gene:
FBXO42 (F-box protein 42) is a protein-coding gene.

UniProtKB/Swiss-Prot: FBX42_HUMAN, Q6P3S6
Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Specifically recognizes p53/TP53, promoting its ubiquitination and degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO42 gene promoter:
         STAT1   AML1a   STAT1beta   STAT1alpha   GATA-1   CREB   MZF-1   POU2F1   POU2F1a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO42 promoter sequence
   Search Chromatin IP Primers for FBXO42

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO42


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23-p36.11   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.23-p36.11

FBXO42 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO42 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M016620:  view genomic region     (about GC identifiers)

Start:
16,573,334 bp from pter      End:
16,678,949 bp from pter
Size:
105,616 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBX42_HUMAN, Q6P3S6 (See protein sequence)
Recommended Name: F-box only protein 42  
Size: 717 amino acids; 77839 Da
Subunit: Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain)
with p53/TP53; interaction is direct
Sequence caution: Sequence=CAI22561.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KP30 Q5TEU8 Q86XI0 Q8N3N4 Q8N5F8 Q9BRM0 Q9P2L4

Explore the universe of human proteins at neXtProt for FBXO42: NX_Q6P3S6

Explore proteomics data for FBXO42 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys564
  • Modification sites at PhosphoSitePlus

  • See FBXO42 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061867.1  
    ENSEMBL proteins: 
     ENSP00000364742   ENSP00000415663   ENSP00000412416  

    FBXO42 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FBXO42
    OriGene Protein Over-expression Lysate for FBXO42
    OriGene MassSpec for FBXO42
    OriGene Custom Protein Services for FBXO42
    GenScript Custom Purified and Recombinant Proteins Services for FBXO42
    Novus Biologicals FBXO42 Proteins
    Novus Biologicals FBXO42 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO42

     
    Search eBioscience for Proteins for FBXO42 

    FBXO42 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FBXO42
    OriGene Custom Antibody Services for FBXO42
    Novus Biologicals FBXO42 Antibodies
    Abcam antibodies for FBXO42
    Cloud-Clone Corp. Antibodies for FBXO42
    Search ThermoFisher Antibodies for FBXO42
    LSBio Antibodies in human, mouse, rat for FBXO42

    FBXO42 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXO42
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXO42
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXO42
    Cloud-Clone Corp. CLIAs for FBXO42
    Search eBioscience for ELISAs for FBXO42 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBXO: F-boxes / "other"

    3 InterPro protein domains:
     IPR001810 F-box_dom
     IPR011498 Kelch_2
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q6P3S6

    ProtoNet protein and cluster: Q6P3S6

    1 Blocks protein domain: IPB011498 Kelch

    UniProtKB/Swiss-Prot: FBX42_HUMAN, Q6P3S6
    Similarity: Contains 1 F-box domain
    Similarity: Contains 4 Kelch repeats


    Find genes that share domains with FBXO42           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX42_HUMAN, Q6P3S6
    Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
    Specifically recognizes p53/TP53, promoting its ubiquitination and degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXO42           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO42
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO42

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO42
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO42

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXO42:
    hsa-mir-186-5p (MIRT044952)

    Block miRNA regulation of human, mouse, rat FBXO42 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO42 (see all 15):
    hsa-miR-4264 hsa-miR-601 hsa-miR-3200-5p hsa-miR-4254 hsa-miR-875-3p hsa-miR-634 hsa-miR-571 hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO42 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO42
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO42

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXO42

    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO42 (see all 7)
    OriGene ORF clones in mouse, rat for FBXO42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO42 (NM_018994)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO42

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXO42
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO42 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO42


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO42
    Interactions:

        Search GeneGlobe Interaction Network for FBXO42

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FBXO42 (Q6P3S63 ENSP000003647424) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOBP627453, ENSP000002722334I2D: score=2 STRING: ENSP00000272233
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
    SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO42 (FBX42)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBXO42 gene: 
    NM_018994.1  

    Unigene Cluster for FBXO42:

    F-box protein 42
    Hs.522384  [show with all ESTs]
    Unigene Representative Sequence: AB037753
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375592(uc001ayf.3 uc001ayg.3) ENST00000456164 ENST00000444116
    ENST00000478089(uc001ayh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXO42 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO42 (see all 15):
    hsa-miR-4264 hsa-miR-601 hsa-miR-3200-5p hsa-miR-4254 hsa-miR-875-3p hsa-miR-634 hsa-miR-571 hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO42 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO42
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO42
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO42 (see all 7)
    OriGene ORF clones in mouse, rat for FBXO42
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO42 (NM_018994)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO42
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO42
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXO42
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO42
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO42
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO42
      QuantiFast Probe-based Assays in human, mouse, rat FBXO42

    Additional mRNA sequence: 

    AB037753.1 AK025059.1 AK055598.1 AK310671.1 AL050213.1 AL833207.1 AL833874.1 BC006174.1 
    BC032439.1 BC043410.1 BC047296.1 BC063864.1 

    13 DOTS entries:

    DT.95150146  DT.410824  DT.97842205  DT.121345546  DT.121345557  DT.121345565  DT.91831961  DT.91975189 
    DT.95329367  DT.100698532  DT.121345428  DT.121345476  DT.95105497 

    Selected AceView cDNA sequences (see all 153):

    Z41965 AB037753 CR615859 BI908071 BQ709415 AI917214 BP429334 BQ636922 
    BX095277 AA344224 BC063864 AI290050 CB123088 AI220199 BM691650 CR602597 
    AA906724 AA322030 AA257075 BC047296 AI123742 BQ069858 BM683886 AW292466 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXO42 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
    SP1:                          -     -     -     -     -     -                                         -                                                     -   
    SP2:                          -     -     -     -     -                                               -                                                         
    SP3:                          -     -     -     -     -     -                                         -     -     -                                             
    SP4:                          -           -     -     -                                                                                                         
    SP5:                          -           -     -     -                                                                                                         

    ExUns: 11b ^ 12 ^ 13a · 13b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for FBXO42

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBXO42 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FBXO42 Expression
    About this image

    FBXO42 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO42 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522384
        Custom PCR Arrays for FBXO42
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXO42
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO42
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO42
    QuantiTect SYBR Green Assays in human, mouse, rat FBXO42
    QuantiFast Probe-based Assays in human, mouse, rat FBXO42
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO42

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO42 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo421 , 5 F-box protein 421, 5 88.8(n)1
    95.4(a)1
      4 (73.41 cM)5
    2134991  NM_172518.31  NP_766106.21 
     1411479135 
    chicken
    (Gallus gallus)
    Aves FBXO421 F-box protein 42 80.35(n)
    91.62(a)
      419461  XM_417619.4  XP_417619.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO426
    F-box protein 42
    91(a)
    1 ↔ 1
    AAWZ02039169(232-7274)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53432 Xenopus laevis transcribed sequence with weak similarity more 80.69(n)    BX850150.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.242232 Danio rerio cDNA clone MGC64224 IMAGE6799918, complete more 77.66(n)    BC053311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67586
    --
    29(a)
    1 ↔ 1
    2R(18062413-18064933)
    worm
    (Caenorhabditis elegans)
    Secernentea Y50D7A.16
    Protein Y50D7A.1 (Y50D7A.1) mRNA, complete cds
    21(a)
    1 ↔ 1
    III(292649-314266) WBGene00021751


    ENSEMBL Gene Tree for FBXO42 (if available)
    TreeFam Gene Tree for FBXO42 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBXO42 (see all 2109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841736201,2
    --16473810(+) ATTCCC/GTACTG 1 -- int10--------
    rs1433828401,2
    --16474061(+) TTTGGC/GAACTT 1 -- int10--------
    rs356404251,2
    C--16474101(+) TTCCA-/CAAT  
            
    CAGAC
    1 -- int10--------
    rs740549951,2
    C,F--16474168(+) CTAGGC/TGGTCA 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1458041481,2
    --16474229(+) GAATAA/CAATCC 1 -- ut310--------
    rs1145819891,2
    F--16474316(+) TCCTCT/CGTGGT 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1150647341,2
    C,F--16474356(+) TACCCC/TGACAG 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1384296211,2
    --16474402(+) TGCAAC/TTTACA 1 -- ut310--------
    rs75363901,2
    C,F,A,H--16474499(+) AGTCTA/GTTCTC 1 -- ut3123Minor allele frequency- G:0.31NA NS EA WA CSA 2480
    rs1130033241,2
    C--16474769(+) AATGCT/CTACAC 1 -- ut312Minor allele frequency- C:0.06CSA WA 120

    HapMap Linkage Disequilibrium report for FBXO42 (16573334 - 16678949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for FBXO42:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667137CNV Deletion23128226
    esv2618916CNV Deletion19546169
    esv1036042CNV Insertion17803354
    nsv3520CNV Insertion18451855
    nsv833869CNV Loss17160897
    dgv174n71CNV Loss21882294
    nsv870978CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO42
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO42

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609109    OMIM disorders: --


    Find genes that share disorders with FBXO42           About GenesLikeMe


    Export disorders for FBXO42 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBXO42 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with FBXO42)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. (PubMed id 19509332)1, 2 Sun L.... Shang Y. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1 Cui Y.... Zhang L. (EMBO J. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)
    10. Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization. (PubMed id 21127074)1 Sun L....Shang Y. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54455 HGNC: 29249 AceView: FBXO42 Ensembl:ENSG00000037637 euGenes: HUgn54455
    ECgene: FBXO42 H-InvDB: FBXO42

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1332

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBXO42 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FBXO42 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBXO42 gene:
    Search GeneIP for patents involving FBXO42

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FBXO42   OriGene RNAi products in human, mouse, rat for FBXO42  
     OriGene qPCR primer pairs and template standards for FBXO42   OriGene Protein Over-expression Lysate for FBXO42  
     OriGene MassSpec something-or-other for FBXO42   OriGene clones in human, mouse for FBXO42  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXO42   OriGene Purified Protein for FBXO42  
     OriGene ORF clones in mouse, rat for FBXO42   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXO42   OriGene Custom Protein Services for FBXO42  

     
     
     Block miRNA regulation of human, mouse, rat FBXO42 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXO42
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO42 Predesigned siRNA for gene silencing in human, mouse, rat FBXO42
     QuantiFast Probe-based Assays in human, mouse, rat FBXO42 QuantiTect SYBR Green Assays in human, mouse, rat FBXO42
     Custom PCR Arrays for FBXO42 Search Chromatin IP Primers for FBXO42
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO42  Search GeneGlobe Interaction Network for FBXO42
     Regulatory tfbs in FBXO42 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBXO42 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO42
     GenScript Custom Assay Services for FBXO42 GenScript Custom overexpressing Cell Line Services for FBXO42
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBXO42 (FBX42)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBXO42 antibodies
     FBXO42 proteins
     FBXO42 lysates
     Antibodies for FBXO42
     See all of Abcam's Antibodies, Kits and Proteins for FBXO42
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBXO42
     Antibodies for FBXO42
     ELISAs for FBXO42
     CLIAs for FBXO42



     Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO42
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO42
     SwitchGear 3'UTR luciferase reporter plasmids for FBXO42
     SwitchGear Promoter luciferase reporter plasmids for FBXO42
     Search ThermoFisher Antibodies for FBXO42
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO42
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO42
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO42
     LSBio Antibodies in human, mouse, rat for FBXO42
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FBXO42
      Search eBioscience for proteins for FBXO42
      Search eBioscience for elisas for FBXO42
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXO42 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4