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Aliases for FBXO42 Gene

Aliases for FBXO42 Gene

  • F-Box Protein 42 2 3 5
  • Just One F-Box And Kelch Domain-Containing Protein 3 4
  • Fbx42 3 4
  • JFK 3 4
  • KIAA1332 4

External Ids for FBXO42 Gene

Previous GeneCards Identifiers for FBXO42 Gene

  • GC01M015956
  • GC01M016321
  • GC01M016445
  • GC01M016575
  • GC01M016577
  • GC01M015093
  • GC01M016580
  • GC01M016582
  • GC01M016584
  • GC01M016593
  • GC01M016603
  • GC01M016612
  • GC01M016620

Summaries for FBXO42 Gene

Entrez Gene Summary for FBXO42 Gene

  • Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

GeneCards Summary for FBXO42 Gene

FBXO42 (F-Box Protein 42) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO42 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO42 Gene

Genomics for FBXO42 Gene

Regulatory Elements for FBXO42 Gene

Promoters for FBXO42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO42 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO42 Gene

Chromosome:
1
Start:
16,246,839 bp from pter
End:
16,352,491 bp from pter
Size:
105,653 bases
Orientation:
Minus strand

Genomic View for FBXO42 Gene

Genes around FBXO42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO42 Gene

Proteins for FBXO42 Gene

  • Protein details for FBXO42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3S6-FBX42_HUMAN
    Recommended name:
    F-box only protein 42
    Protein Accession:
    Q6P3S6
    Secondary Accessions:
    • B3KP30
    • Q5TEU8
    • Q86XI0
    • Q8N3N4
    • Q8N5F8
    • Q9BRM0
    • Q9P2L4

    Protein attributes for FBXO42 Gene

    Size:
    717 amino acids
    Molecular mass:
    77839 Da
    Quaternary structure:
    • Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.
    SequenceCaution:
    • Sequence=CAI22561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FBXO42 Gene

Proteomics data for FBXO42 Gene at MOPED

Post-translational modifications for FBXO42 Gene

  • Ubiquitination at Lys 564
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO42 Gene

Domains & Families for FBXO42 Gene

Gene Families for FBXO42 Gene

Protein Domains for FBXO42 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3S6

UniProtKB/Swiss-Prot:

FBX42_HUMAN :
  • Contains 1 F-box domain.
  • Contains 4 Kelch repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 4 Kelch repeats.
genes like me logo Genes that share domains with FBXO42: view

Function for FBXO42 Gene

Molecular function for FBXO42 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
genes like me logo Genes that share phenotypes with FBXO42: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO42 Gene

Localization for FBXO42 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO42 Gene COMPARTMENTS Subcellular localization image for FBXO42 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO42 Gene

Pathways & Interactions for FBXO42 Gene

SuperPathways for FBXO42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO42 Gene

Drugs & Compounds for FBXO42 Gene

No Compound Related Data Available

Transcripts for FBXO42 Gene

Unigene Clusters for FBXO42 Gene

F-box protein 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO42 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - -
SP7: - - -
SP8:
SP9:
SP10: - -
SP11: - - -
SP12: - -
SP13:

ExUns: 11b ^ 12 ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FBXO42 Gene

GeneLoc Exon Structure for
FBXO42
ECgene alternative splicing isoforms for
FBXO42

Expression for FBXO42 Gene

mRNA expression in normal human tissues for FBXO42 Gene

Protein differential expression in normal tissues from HIPED for FBXO42 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.1), Fetal Brain (16.0), and Placenta (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO42 Gene



SOURCE GeneReport for Unigene cluster for FBXO42 Gene Hs.522384

genes like me logo Genes that share expression patterns with FBXO42: view

Protein tissue co-expression partners for FBXO42 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO42 Gene

Orthologs for FBXO42 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO42 35
  • 87.59 (n)
  • 95.12 (a)
FBXO42 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO42 35
  • 93.49 (n)
  • 97.07 (a)
FBXO42 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo42 35
  • 88.8 (n)
  • 95.4 (a)
Fbxo42 16
Fbxo42 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO42 35
  • 99.81 (n)
  • 99.86 (a)
FBXO42 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo42 35
  • 91.56 (n)
  • 97.73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO42 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO42 35
  • 80.35 (n)
  • 91.62 (a)
FBXO42 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO42 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo42 35
  • 69.68 (n)
  • 77.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5343 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24223 35
fbxo42 35
  • 69.06 (n)
  • 80.14 (a)
fbxo42 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6758 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y50D7A.1 36
  • 21 (a)
OneToOne
Species with no ortholog for FBXO42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO42 Gene

ENSEMBL:
Gene Tree for FBXO42 (if available)
TreeFam:
Gene Tree for FBXO42 (if available)

Paralogs for FBXO42 Gene

No data available for Paralogs for FBXO42 Gene

Variants for FBXO42 Gene

Sequence variations from dbSNP and Humsavar for FBXO42 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12069239 - 16,251,413(+) TTCAG(C/G/T)AGCAG reference, missense
rs221023 -- 16,257,974(-) GCGAg(G/T)catgg intron-variant
rs557368 -- 16,348,632(-) cctct(A/G/T)cctcc intron-variant
rs557432 -- 16,348,619(-) ggttc(C/G)agcga intron-variant
rs557530 -- 16,348,581(-) tggga(G/T)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO42 Gene

Variant ID Type Subtype PubMed ID
dgv174n71 CNV Loss 21882294
nsv833869 CNV Loss 17160897
nsv870978 CNV Loss 21882294
nsv3520 CNV Insertion 18451855
esv1036042 CNV Insertion 17803354
esv2618916 CNV Deletion 19546169
esv2667137 CNV Deletion 23128226

Variation tolerance for FBXO42 Gene

Residual Variation Intolerance Score: 5.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.12; 75.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO42 Gene

HapMap Linkage Disequilibrium report
FBXO42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO42 Gene

Disorders for FBXO42 Gene

Relevant External Links for FBXO42

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO42

No disorders were found for FBXO42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO42 Gene

Publications for FBXO42 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. (PMID: 25792601) Yan R. … Shang Y. (Genes Dev. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genetic analysis of the FBXO42 gene in Chinese Han patients with Parkinson's disease. (PMID: 24063688) Gao K. … Deng H. (BMC Neurol 2013) 3
  5. Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization. (PMID: 21127074) Sun L. … Shang Y. (J. Biol. Chem. 2011) 3

Products for FBXO42 Gene

Sources for FBXO42 Gene

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