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Aliases for FBXO41 Gene

Aliases for FBXO41 Gene

  • F-Box Protein 41 2 3 5
  • FBX41 3 4
  • KIAA1940 4

External Ids for FBXO41 Gene

Previous GeneCards Identifiers for FBXO41 Gene

  • GC02M073458
  • GC02M073394
  • GC02M073217
  • GC02M073481

Summaries for FBXO41 Gene

Entrez Gene Summary for FBXO41 Gene

  • This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]

GeneCards Summary for FBXO41 Gene

FBXO41 (F-Box Protein 41) is a Protein Coding gene. An important paralog of this gene is ZNF365.

UniProtKB/Swiss-Prot for FBXO41 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO41 Gene

Genomics for FBXO41 Gene

Regulatory Elements for FBXO41 Gene

Enhancers for FBXO41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO41 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO41 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO41 Gene

73,254,682 bp from pter
73,284,453 bp from pter
29,772 bases
Minus strand

Genomic View for FBXO41 Gene

Genes around FBXO41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO41 Gene

Proteins for FBXO41 Gene

  • Protein details for FBXO41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 41
    Protein Accession:
    Secondary Accessions:
    • G3V0Z7
    • Q2M1V8

    Protein attributes for FBXO41 Gene

    875 amino acids
    Molecular mass:
    94496 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXO41 Gene

Proteomics data for FBXO41 Gene at MOPED

Post-translational modifications for FBXO41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO41 Gene

Domains & Families for FBXO41 Gene

Gene Families for FBXO41 Gene

Protein Domains for FBXO41 Gene

Suggested Antigen Peptide Sequences for FBXO41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO41: view

Function for FBXO41 Gene

Molecular function for FBXO41 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes for FBXO41 Gene

genes like me logo Genes that share phenotypes with FBXO41: view

Animal Models for FBXO41 Gene

MGI Knock Outs for FBXO41:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO41 Gene

Localization for FBXO41 Gene

Subcellular locations from

Jensen Localization Image for FBXO41 Gene COMPARTMENTS Subcellular localization image for FBXO41 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO41 Gene

Pathways & Interactions for FBXO41 Gene

SuperPathways for FBXO41 Gene

No Data Available

Interacting Proteins for FBXO41 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000428646 Q8TF61-FBX41_HUMAN for FBXO41 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for FBXO41 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO41 Gene

Drugs & Compounds for FBXO41 Gene

No Compound Related Data Available

Transcripts for FBXO41 Gene

Unigene Clusters for FBXO41 Gene

F-box protein 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO41 Gene

No ASD Table

Relevant External Links for FBXO41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO41 Gene

mRNA expression in normal human tissues for FBXO41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO41 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for FBXO41 Gene

This gene is overexpressed in Rectum (24.4), Urinary Bladder (19.6), and Lung (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO41 Gene

SOURCE GeneReport for Unigene cluster for FBXO41 Gene Hs.23158

genes like me logo Genes that share expression patterns with FBXO41: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXO41 Gene

Orthologs for FBXO41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO41 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO41 35
  • 92.07 (n)
  • 97.68 (a)
FBXO41 36
  • 97 (a)
(Canis familiaris)
Mammalia FBXO41 35
  • 92.64 (n)
  • 98.05 (a)
FBXO41 36
  • 98 (a)
(Mus musculus)
Mammalia Fbxo41 35
  • 88.74 (n)
  • 97.14 (a)
Fbxo41 16
Fbxo41 36
  • 97 (a)
(Pan troglodytes)
Mammalia FBXO41 35
  • 99.66 (n)
  • 99.87 (a)
FBXO41 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo41 35
  • 88.7 (n)
  • 97.37 (a)
(Monodelphis domestica)
Mammalia FBXO41 36
  • 87 (a)
(Gallus gallus)
Aves FBXO41 35
  • 76.9 (n)
  • 79.2 (a)
FBXO41 36
  • 77 (a)
(Anolis carolinensis)
Reptilia FBXO41 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo41 35
  • 71.52 (n)
  • 75.97 (a)
(Danio rerio)
Actinopterygii fbxo41 35
  • 66.29 (n)
  • 70.61 (a)
fbxo41 36
  • 69 (a)
FBXO41 (1 of 2) 36
  • 46 (a)
Species with no ortholog for FBXO41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO41 Gene

Gene Tree for FBXO41 (if available)
Gene Tree for FBXO41 (if available)

Paralogs for FBXO41 Gene

Paralogs for FBXO41 Gene

genes like me logo Genes that share paralogs with FBXO41: view

Variants for FBXO41 Gene

Sequence variations from dbSNP and Humsavar for FBXO41 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs480538 -- 73,258,390(+) CTGTA(C/T)TGCTG utr-variant-3-prime
rs502930 -- 73,265,092(+) ATCCT(C/T)GTGCA intron-variant
rs526106 -- 73,265,486(+) CTGGG(A/T)CCGCT reference, missense
rs546576 -- 73,274,325(-) AGTAG(C/T)GCACA intron-variant
rs1652521 -- 73,265,529(+) CCCAA(C/G)CCCCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FBXO41 Gene

Variant ID Type Subtype PubMed ID
nsv2776 CNV Loss 18451855

Variation tolerance for FBXO41 Gene

Gene Damage Index Score: 6.42; 77.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO41 Gene

Disorders for FBXO41 Gene

Relevant External Links for FBXO41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO41 Gene

Publications for FBXO41 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. (PMID: 26063905) Mukherjee C. … StegmA1ller J. (J. Neurosci. 2015) 3
  3. Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease. (PMID: 23777664) Liang H. … Deng H. (Parkinsonism Relat. Disord. 2013) 3
  4. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for FBXO41 Gene

Sources for FBXO41 Gene