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FBXO41 Gene(Protein Coding)

F-Box Protein 41

GCID:
GC02M073254
GIFtS:
44
Genes Participants
UDN Logo

Aliases for FBXO41 Gene

Aliases for FBXO41 Gene

  • F-Box Protein 41 2 3 5
  • FBX41 3 4
  • F-Box Only Protein 41 3
  • KIAA1940 4

External Ids for FBXO41 Gene

Previous GeneCards Identifiers for FBXO41 Gene

  • GC02M073458
  • GC02M073394
  • GC02M073217
  • GC02M073481

Summaries for FBXO41 Gene

Entrez Gene Summary for FBXO41 Gene

  • This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]

GeneCards Summary for FBXO41 Gene

FBXO41 (F-Box Protein 41) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ZNF365.

UniProtKB/Swiss-Prot for FBXO41 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO41 Gene

Genomics for FBXO41 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO41 Gene

Enhancers for FBXO41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G073892 2 FANTOM5 Ensembl ENCODE dbSUPER 10 -609.3 -609297 3.2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 DUSP11 PCGF1 STAMBP SEMA4F ENSG00000273245 SMYD5 ACTG2 MTHFD2 CCDC142 DGUOK
GH02G073232 1.2 ENCODE 12.5 +50.1 50120 3.9 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC DUSP11 ENSG00000273245 FBXO41 PRADC1 DGUOK-AS1 CCT7 PIR47890
GH02G073384 1.4 FANTOM5 ENCODE 10.2 -101.6 -101623 2.3 HDGF MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 ZNF263 DUSP11 ALMS1P1 ENSG00000273245 DGUOK-AS1 SMYD5 FBXO41 ALMS1 GNG5P4
GH02G073062 1.3 Ensembl ENCODE 10.1 +220.6 220573 3.3 PKNOX1 MLX ARID4B SIN3A ZNF48 ZNF121 SLC30A9 GLIS2 ZNF766 ZNF143 SMYD5 FBXO41 EMX1 RAB11FIP5 LOC105374800 GC02M073108 PIR43769
GH02G073828 1.3 ENCODE dbSUPER 10 -545.6 -545628 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SEMA4F SMYD5 DCTN1 FBXO41 STAMBP TPRKB ALMS1P1 LOC105374807
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO41 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119048 53 1201 SIN3A DMAP1 ZNF48 GLIS2 ZNF263 SP3 SP5 ZHX2 JUNB REST

Transcription factor binding sites by QIAGEN in the FBXO41 gene promoter:

Genomic Location for FBXO41 Gene

Chromosome:
2
Start:
73,254,682 bp from pter
End:
73,284,453 bp from pter
Size:
29,772 bases
Orientation:
Minus strand

Genomic View for FBXO41 Gene

Genes around FBXO41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO41 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO41 Gene

Proteins for FBXO41 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBXO41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF61-FBX41_HUMAN
    Recommended name:
    F-box only protein 41
    Protein Accession:
    Q8TF61
    Secondary Accessions:
    • G3V0Z7
    • Q2M1V8

    Protein attributes for FBXO41 Gene

    Size:
    875 amino acids
    Molecular mass:
    94496 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXO41 Gene

Protein Expression for FBXO41 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO41 Gene

Domains & Families for FBXO41 Gene

Gene Families for FBXO41 Gene

HGNC:

Protein Domains for FBXO41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO41: view

No data available for UniProtKB/Swiss-Prot for FBXO41 Gene

Function for FBXO41 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO41 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXO41: view
genes like me logo Genes that share phenotypes with FBXO41: view

Animal Models for FBXO41 Gene

MGI Knock Outs for FBXO41:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO41 Gene

Localization for FBXO41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO41 gene
Compartment Confidence
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for FBXO41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO41 Gene

Pathways & Interactions for FBXO41 Gene

genes like me logo Genes that share pathways with FBXO41: view

Gene Ontology (GO) - Biological Process for FBXO41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO41: view

No data available for SIGNOR curated interactions for FBXO41 Gene

Drugs & Compounds for FBXO41 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FBXO41 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO41 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(122) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO41 Gene

F-box protein 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO41 Gene

No ASD Table

Relevant External Links for FBXO41 Gene

GeneLoc Exon Structure for
FBXO41
ECgene alternative splicing isoforms for
FBXO41

Expression for FBXO41 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO41 Gene

mRNA expression in normal human tissues for FBXO41 Gene
mRNA expression by BioGPS for FBXO41 GenemRNA expression by GTEx for FBXO41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO41 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for FBXO41 Gene

This gene is overexpressed in Rectum (24.4), Urinary Bladder (19.6), and Lung (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO41 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO41 Gene:

FBXO41

SOURCE GeneReport for Unigene cluster for FBXO41 Gene:

Hs.23158

Evidence on tissue expression from TISSUES for FBXO41 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with FBXO41: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO41 Gene

Orthologs for FBXO41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO41 34 35
  • 99.66 (n)
dog
(Canis familiaris)
 Mammalia FBXO41 34 35
  • 92.64 (n)
cow
(Bos Taurus)
 Mammalia FBXO41 34 35
  • 92.07 (n)
mouse
(Mus musculus)
 Mammalia Fbxo41 34 16 35
  • 88.74 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo41 34
  • 88.7 (n)
oppossum
(Monodelphis domestica)
 Mammalia FBXO41 35
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FBXO41 34 35
  • 76.9 (n)
lizard
(Anolis carolinensis)
 Reptilia FBXO41 35
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo41 34
  • 71.52 (n)
zebrafish
(Danio rerio)
 Actinopterygii fbxo41 34 35
  • 66.29 (n)
FBXO41 (1 of 2) 35
  • 46 (a)
 OneToMany
Species where no ortholog for FBXO41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO41 Gene

ENSEMBL:
Gene Tree for FBXO41 (if available)
TreeFam:
Gene Tree for FBXO41 (if available)

Paralogs for FBXO41 Gene

Paralogs for FBXO41 Gene

genes like me logo Genes that share paralogs with FBXO41: view

Variants for FBXO41 Gene

Sequence variations from dbSNP and Humsavar for FBXO41 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000419745 -- 73,274,084(+) AGTCC(C/T)GCAGC intron-variant
rs1000443042 -- 73,262,352(+) CACAC(C/T)GGATG intron-variant
rs1000499761 -- 73,274,329(+) CACTA(C/T)TTTGC intron-variant
rs1000551221 -- 73,263,093(+) ACAGA(G/T)TAATG intron-variant
rs1000557266 -- 73,256,962(+) TGTCT(A/G)GGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO41 Gene

Variant ID Type Subtype PubMed ID
esv3583864 CNV loss 25503493
nsv1013190 CNV loss 25217958
nsv2776 CNV deletion 18451855

Variation tolerance for FBXO41 Gene

Gene Damage Index Score: 6.42; 77.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO41 Gene

Disorders for FBXO41 Gene

Relevant External Links for FBXO41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO41

No disorders were found for FBXO41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO41 Gene

Publications for FBXO41 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. (PMID: 26063905) Mukherjee C. … StegmA1ller J. (J. Neurosci. 2015) 3 64
  4. Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease. (PMID: 23777664) Liang H. … Deng H. (Parkinsonism Relat. Disord. 2013) 3 64
  5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. (PMID: 19028597) Ebstein F. … Kloetzel P.-M. (Int. J. Biochem. Cell Biol. 2009) 3 64

Products for FBXO41 Gene

Sources for FBXO41 Gene

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