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Aliases for FBXO41 Gene

Aliases for FBXO41 Gene

  • F-Box Protein 41 2 3 5
  • FBX41 3 4
  • F-Box Only Protein 41 3
  • KIAA1940 4

External Ids for FBXO41 Gene

Previous GeneCards Identifiers for FBXO41 Gene

  • GC02M073458
  • GC02M073394
  • GC02M073217
  • GC02M073481

Summaries for FBXO41 Gene

Entrez Gene Summary for FBXO41 Gene

  • This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]

GeneCards Summary for FBXO41 Gene

FBXO41 (F-Box Protein 41) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is ZNF365.

UniProtKB/Swiss-Prot for FBXO41 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO41 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO41 Gene

Genomics for FBXO41 Gene

Regulatory Elements for FBXO41 Gene

Enhancers for FBXO41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H073232 1.2 ENCODE 12.5 +50.1 50120 3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ENSG00000273245 DUSP11 CCT7 FBXO41 TPRKB MOB1A PRADC1 ALMS1 DGUOK-AS1 PIR47890
GH02H073244 0.7 ENCODE 11.6 +40.0 40017 0 PKNOX1 ZNF362 NFIB SIN3A CEBPB MNT DPF2 GATA3 GATA2 SCRT2 SMYD5 FBXO41 PRADC1 PIR47890
GH02H073640 1 Ensembl ENCODE 6.8 -356.3 -356335 0 ELF3 FOXA2 SAP130 TAF1 MAX CEBPG RAD21 RARA YY1 MAFK ALMS1P1 TPRKB FBXO41 GC02P073640 GC02P073585
GH02H073283 0.9 ENCODE 0.7 -0.1 -84 2 HDGF SIN3A ARID4B DMAP1 GLIS2 RUNX3 SP3 SP5 ZHX2 MXD4 FBXO41 EGR4
GH02H073268 1 Ensembl ENCODE 0.4 +15.2 15200 1 GTF2F1 CTCF MXI1 SIN3A YBX1 ZNF121 E2F1 GLIS2 ELK1 POLR2A SMYD5 FBXO41 PIR47890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO41 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119048 53 1201 TBL1XR1 SIN3A ZNF76 DMAP1 DNMT3B RARA GLIS2 EGR1 RUNX3 IKZF2

Genomic Location for FBXO41 Gene

Chromosome:
2
Start:
73,254,682 bp from pter
End:
73,284,453 bp from pter
Size:
29,772 bases
Orientation:
Minus strand

Genomic View for FBXO41 Gene

Genes around FBXO41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO41 Gene

Proteins for FBXO41 Gene

  • Protein details for FBXO41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF61-FBX41_HUMAN
    Recommended name:
    F-box only protein 41
    Protein Accession:
    Q8TF61
    Secondary Accessions:
    • G3V0Z7
    • Q2M1V8

    Protein attributes for FBXO41 Gene

    Size:
    875 amino acids
    Molecular mass:
    94496 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXO41 Gene

Post-translational modifications for FBXO41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO41 Gene

Domains & Families for FBXO41 Gene

Gene Families for FBXO41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO41: view

No data available for UniProtKB/Swiss-Prot for FBXO41 Gene

Function for FBXO41 Gene

Molecular function for FBXO41 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXO41: view
genes like me logo Genes that share phenotypes with FBXO41: view

Animal Models for FBXO41 Gene

MGI Knock Outs for FBXO41:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO41
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO41 Gene

Localization for FBXO41 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO41 gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXO41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO41 Gene

Pathways & Interactions for FBXO41 Gene

genes like me logo Genes that share pathways with FBXO41: view

Gene Ontology (GO) - Biological Process for FBXO41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO41: view

No data available for SIGNOR curated interactions for FBXO41 Gene

Drugs & Compounds for FBXO41 Gene

(1) Drugs for FBXO41 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with FBXO41: view

Transcripts for FBXO41 Gene

Unigene Clusters for FBXO41 Gene

F-box protein 41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO41
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO41 Gene

No ASD Table

Relevant External Links for FBXO41 Gene

GeneLoc Exon Structure for
FBXO41
ECgene alternative splicing isoforms for
FBXO41

Expression for FBXO41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO41 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.2), Brain - Frontal Cortex (BA9) (x4.8), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for FBXO41 Gene

This gene is overexpressed in Rectum (24.4), Urinary Bladder (19.6), and Lung (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO41 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO41 Gene:

FBXO41

SOURCE GeneReport for Unigene cluster for FBXO41 Gene:

Hs.23158

Evidence on tissue expression from TISSUES for FBXO41 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with FBXO41: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO41 Gene

Orthologs for FBXO41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO41 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia FBXO41 33 34
  • 92.64 (n)
cow
(Bos Taurus)
Mammalia FBXO41 33 34
  • 92.07 (n)
mouse
(Mus musculus)
Mammalia Fbxo41 33 16 34
  • 88.74 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo41 33
  • 88.7 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO41 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO41 33 34
  • 76.9 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO41 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo41 33
  • 71.52 (n)
zebrafish
(Danio rerio)
Actinopterygii fbxo41 33 34
  • 66.29 (n)
FBXO41 (1 of 2) 34
  • 46 (a)
OneToMany
Species where no ortholog for FBXO41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO41 Gene

ENSEMBL:
Gene Tree for FBXO41 (if available)
TreeFam:
Gene Tree for FBXO41 (if available)

Paralogs for FBXO41 Gene

Paralogs for FBXO41 Gene

genes like me logo Genes that share paralogs with FBXO41: view

Variants for FBXO41 Gene

Sequence variations from dbSNP and Humsavar for FBXO41 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000419745 -- 73,274,084(+) AGTCC(C/T)GCAGC intron-variant
rs1000443042 -- 73,262,352(+) CACAC(C/T)GGATG intron-variant
rs1000499761 -- 73,274,329(+) CACTA(C/T)TTTGC intron-variant
rs1000551221 -- 73,263,093(+) ACAGA(G/T)TAATG intron-variant
rs1000557266 -- 73,256,962(+) TGTCT(A/G)GGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO41 Gene

Variant ID Type Subtype PubMed ID
esv3583864 CNV loss 25503493
nsv1013190 CNV loss 25217958
nsv2776 CNV deletion 18451855

Variation tolerance for FBXO41 Gene

Gene Damage Index Score: 6.42; 77.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO41 Gene

Disorders for FBXO41 Gene

Relevant External Links for FBXO41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO41

No disorders were found for FBXO41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO41 Gene

Publications for FBXO41 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  3. Loss of the neuron-specific F-box protein FBXO41 models an ataxia-like phenotype in mice with neuronal migration defects and degeneration in the cerebellum. (PMID: 26063905) Mukherjee C … Stegmüller J (The Journal of neuroscience : the official journal of the Society for Neuroscience 2015) 3 60
  4. Genetic analysis of the F-box only protein 41 gene in Chinese Han patients with Parkinson's disease. (PMID: 23777664) Liang H … Deng H (Parkinsonism & related disorders 2013) 3 60
  5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. (PMID: 19028597) Ebstein F … Kloetzel PM (The international journal of biochemistry & cell biology 2009) 3 60

Products for FBXO41 Gene

Sources for FBXO41 Gene

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