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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FBXO41 Gene

protein-coding GIFtS: 43
GCID: GC02M073481

F-box protein 41

Explore 1 disease affiliated with
FBXO41 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
F-Box Protein 41¹ ²
KIAA1940¹ ³ ⁵
FBX41² ³ ⁵
Fbx41¹
F-Box Only Protein 41²

External Ids:	HGNC: 29409¹	Entrez Gene: 150726²	Ensembl: ENSG00000163013⁷	OMIM: 609108⁵	UniProtKB: Q8TF61³

Export aliases for FBXO41 gene to outside databases

Previous GC identifers: GC02M073458 GC02M073394 GC02M073217

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO41:

Members of the F-box protein family, such as FBXO41, are characterized by an approximately 40-amino acid F-box motif.

SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as

protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination

targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: FBX41_HUMAN, Q8TF61

Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FBXO41 gene promoter:
GR Egr-3 GATA-3 HTF AP-2gamma AP-2beta GR-alpha Pax-4a AP-2alpha AP-2alphaA
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FBXO41

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO41

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.2 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.2

FBXO41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO41 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M073481: view genomic region (about GC identifiers)

Start:	73,481,810 bp from pter	End:	73,511,559 bp from pter
Size:	29,750 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBX41_HUMAN, Q8TF61 (See protein sequence)

Recommended Name: F-box only protein 41

Size: 875 amino acids; 94496 Da

Subunit: Directly interacts with SKP1 and CUL1 (By similarity)

Secondary accessions: G3V0Z7 Q2M1V8

Explore the universe of human proteins at neXtProt for FBXO41: NX_Q8TF61

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TF61

FBXO41 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073879.2

ENSEMBL proteins:

ENSP00000428646 ENSP00000430968 ENSP00000295133

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	Uscn Proteins for FBXO41

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

FBXO41 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FBXO41 for domains About GeneDecksing

2 InterPro domains/families:

IPR001810 F-box_dom_cyclin-like

IPR015880 Znf_C2H2-like

Graphical View of Domain Structure for InterPro Entry Q8TF61

ProtoNet protein and cluster: Q8TF61

UniProtKB/Swiss-Prot: FBX41_HUMAN, Q8TF61

Similarity: Contains 1 F-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FBX41_HUMAN, Q8TF61

Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By

similarity)

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

FBXO41 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FBXO41:

Downregulation of NF-kappaB pa

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FBXO41

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for FBXO41 (Q8TF61³ ENSP00000295133⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DISC1	Q9NRI5³, ENSP00000355596⁴	I2D: score=2 STRING: ENSP00000355596
SKP1	P63208³, ENSP00000231487⁴	I2D: score=1 STRING: ENSP00000231487
--	ENSP00000393642⁴	STRING: ENSP00000393642

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FBXO41
Search CenterWatch for drugs/clinical trials and news about FBXO41 / FBX41

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FBXO41 gene:

NM_001080410.2

Unigene Cluster for FBXO41:

F-box protein 41

Hs.23158 [show with all ESTs]

Unigene Representative Sequence: NM_001080410

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000521871 ENST00000519873 ENST00000520530 ENST00000520186 ENST00000295133(uc021vjh.1)

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Additional cDNA sequence:

AB075820.1 AK055121.1 AK095028.1 AK127503.1 BC112202.1 CR936834.1

1 DOTS entry:

DT.91694877

24/122 AceView cDNA sequences (see all 122):

AL045779 AW501115 AW501241 BF940066 AK127503 CA308723 BQ691312 BQ890229

AK055121 CA308712 Z38945 AB075820 Z42802 AW502920 BX642243 BE256511

AW501076 BQ575278 AW590225 AI435259 AW575918 AA479727 BU192995 AI028477

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBXO41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATCAGAG

About this image

FBXO41 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FBXO41 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO41

SOURCE GeneReport for Unigene cluster: Hs.23158

SABiosciences Custom PCR Arrays for FBXO41

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FBXO41 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FBXO41¹	F-box protein 41	77.34(n) 79.95(a)		428805 XM_426362.3 XP_426362.3
lizard (Anolis carolinensis)	Reptilia	FBXO41⁶	--	76(a)	1 ↔ 1	GL343815.1(80491-140425)
zebrafish (Danio rerio)	Actinopterygii	fbxo41¹	F-box protein 41	66.67(n) 70.73(a)		567804 XM_691106.4 XP_696198.4

ENSEMBL Gene Tree for FBXO41 (if available)
TreeFam Gene Tree for FBXO41 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FBXO41 gene

ZNF365²

FBXO41 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4852300^1,2		--	73481428(+)	`acaggC/Gcctca`	1	--	int¹		0	--	--	--	--
rs139106246^1,2		--	73481433(+)	`GCCTCA/GCTCAG`	1	--	int¹		0	--	--	--	--
rs187851132^1,2		--	73481460(+)	`GTGCAA/GTGGTG`	1	--	int¹		0	--	--	--	--
rs192371581^1,2		--	73481585(+)	`GAGACA/GGGGTT`	1	--	int¹		0	--	--	--	--
rs148986568^1,2		--	73481586(+)	`AGACAC/GGGTTT`	1	--	int¹		0	--	--	--	--
rs182915273^1,2		--	73481603(+)	`GTTGCC/TCAGAC`	1	--	int¹		0	--	--	--	--
rs72905381^1,2	C,	--	73481691(+)	`GTGCCC/TGCTGG`	1	--	int¹		2		WA	120
rs187215768^1,2		--	73481708(+)	`TTGTTA/GTACTT`	1	--	int¹		0	--	--	--	--
rs116219416^1,2		--	73481710(+)	`GTTATA/TCTTCA`	1	--	int¹		1		NA	120
rs193152443^1,2		--	73481776(+)	`CAGATA/GATAAG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FBXO41 (73481810 - 73511559 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBXO41: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FBXO41 for disorders           About GeneDecksing

OMIM gene information: 609108    OMIM disorders: --

1 disease for FBXO41:    About MalaCards

schizophrenia

Export disorders for FBXO41 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FBXO41 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FBXO41)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)^{1, 2, 3} Nagase T.... Ohara O. (2001)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)¹ Camargo L.M....Brandon N.J. (2007)
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. (PubMed id 15070733)¹ Watanabe N....Osada H. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)¹ Jin J....Harper J.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 150726	HGNC: 29409	AceView: FBXO41	Ensembl:ENSG00000163013	euGenes: HUgn150726
ECgene: FBXO41	H-InvDB: FBXO41

(According to HUGE)
About This Section

HUGE: KIAA1940

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FBXO41	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FBXO41 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FBXO41 gene:
Search GeneIP for patents involving FBXO41

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FBXO41 gene at Home site.

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FBXO41 Gene

F-box protein 41

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FBXO41 Gene

F-box protein 41

Aliasesfor FBXO41 gene

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Genomic Viewsfor FBXO41 gene

Proteinsfor FBXO41 gene

Protein Domains /Familiesfor FBXO41 gene

Functionfor FBXO41 gene

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for FBXO41 gene

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for FBXO41 gene

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for FBXO41 gene

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for FBXO41 gene

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