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Aliases for FBXO4 Gene

Aliases for FBXO4 Gene

  • F-Box Protein 4 2 3 5
  • F-Box Only Protein 4 2 3
  • FBX4 3 4
  • F-Box Protein Fbx4 3

External Ids for FBXO4 Gene

Previous GeneCards Identifiers for FBXO4 Gene

  • GC05P042223
  • GC05P043025
  • GC05P041970
  • GC05P041961
  • GC05P041878

Summaries for FBXO4 Gene

Entrez Gene Summary for FBXO4 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FBXO4 Gene

FBXO4 (F-Box Protein 4) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO4 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Gene Wiki entry for FBXO4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO4 Gene

Genomics for FBXO4 Gene

Regulatory Elements for FBXO4 Gene

Enhancers for FBXO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G041903 1.2 ENCODE 34.4 -20.8 -20770 2.5 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZFP41 FBXO4 SERBP1P6 OXCT1-AS1 CCDC152 C5orf51 PIR36450 GC05P041922
GH05G041869 1.1 ENCODE 29 -54.9 -54943 2.6 HDGF CREB3L1 AGO1 SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 ZNF263 FBXO4 C5orf51 OXCT1 OXCT1-AS1
GH05G041924 1.2 ENCODE 10.6 +0.0 19 2.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D OXCT1 C5orf51 FBXO4 RPSAP38
GH05G041856 1 FANTOM5 ENCODE 11 -68.4 -68409 0.2 HDGF CTCF ESRRA KLF1 RB1 RAD21 RFX5 SCRT2 ZNF143 SMC3 FBXO4 C5orf51 LOC102723752 GC05M041733
GH05G041871 1 Ensembl ENCODE 10.8 -53.4 -53380 0.4 ZBTB21 INSM2 ZNF101 ZNF302 ZNF366 PRDM10 KLF8 ZBTB20 ZNF10 ZEB2 C5orf51 FBXO4 OXCT1 RPS2P22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO4 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000180084 248 1401 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D

Genomic Location for FBXO4 Gene

Chromosome:
5
Start:
41,925,252 bp from pter
End:
42,040,228 bp from pter
Size:
114,977 bases
Orientation:
Plus strand

Genomic View for FBXO4 Gene

Genes around FBXO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO4 Gene

Proteins for FBXO4 Gene

  • Protein details for FBXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT5-FBX4_HUMAN
    Recommended name:
    F-box only protein 4
    Protein Accession:
    Q9UKT5
    Secondary Accessions:
    • Q68CU8
    • Q86VT8
    • Q9UK98

    Protein attributes for FBXO4 Gene

    Size:
    387 amino acids
    Molecular mass:
    44136 Da
    Quaternary structure:
    • Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1. This interaction is prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1.

    Three dimensional structures from OCA and Proteopedia for FBXO4 Gene

    Alternative splice isoforms for FBXO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO4 Gene

Post-translational modifications for FBXO4 Gene

  • Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for FBXO4
  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXO4

No data available for DME Specific Peptides for FBXO4 Gene

Domains & Families for FBXO4 Gene

Gene Families for FBXO4 Gene

Protein Domains for FBXO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO4: view

No data available for UniProtKB/Swiss-Prot for FBXO4 Gene

Function for FBXO4 Gene

Molecular function for FBXO4 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Gene Ontology (GO) - Molecular Function for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 16278047
GO:0042803 protein homodimerization activity IPI 20181953
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with FBXO4: view
genes like me logo Genes that share phenotypes with FBXO4: view

Animal Models for FBXO4 Gene

MGI Knock Outs for FBXO4:

Animal Model Products

CRISPR Products

miRNA for FBXO4 Gene

miRTarBase miRNAs that target FBXO4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO4 Gene

Localization for FBXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO4 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 10531035
GO:0005737 cytoplasm IDA 21378169
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 20181953
genes like me logo Genes that share ontologies with FBXO4: view

Pathways & Interactions for FBXO4 Gene

genes like me logo Genes that share pathways with FBXO4: view

UniProtKB/Swiss-Prot Q9UKT5-FBX4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for FBXO4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007568 aging IEA --
GO:0010608 posttranscriptional regulation of gene expression IEA --
GO:0016567 protein ubiquitination IEA,TAS 24389012
GO:0019725 cellular homeostasis IEA --
genes like me logo Genes that share ontologies with FBXO4: view

Transcripts for FBXO4 Gene

Unigene Clusters for FBXO4 Gene

F-box protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for FBXO4 Gene

GeneLoc Exon Structure for
FBXO4
ECgene alternative splicing isoforms for
FBXO4

Expression for FBXO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO4 Gene

This gene is overexpressed in Stomach (11.6), CD8 Tcells (9.9), Testis (9.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO4 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO4 Gene:

FBXO4

SOURCE GeneReport for Unigene cluster for FBXO4 Gene:

Hs.165575

Evidence on tissue expression from TISSUES for FBXO4 Gene

  • Liver(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FBXO4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO4 Gene

Orthologs for FBXO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO4 35 34
  • 98.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO4 34 35
  • 91.3 (n)
cow
(Bos Taurus)
Mammalia FBXO4 35 34
  • 90.61 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo4 34
  • 86.06 (n)
mouse
(Mus musculus)
Mammalia Fbxo4 34 16 35
  • 85.89 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO4 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO4 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO4 34 35
  • 67.57 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO4 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo4 34
  • 61.4 (n)
Str.20453 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24187 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-46a10.2 34
  • 55.52 (n)
FBXO4 35
  • 43 (a)
OneToOne
Species where no ortholog for FBXO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO4 Gene

ENSEMBL:
Gene Tree for FBXO4 (if available)
TreeFam:
Gene Tree for FBXO4 (if available)

Paralogs for FBXO4 Gene

No data available for Paralogs for FBXO4 Gene

Variants for FBXO4 Gene

Sequence variations from dbSNP and Humsavar for FBXO4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2231917 Esophagus cancer samples 41,925,333(+) CGCAG(C/G)GGAAC upstream-variant-2KB, reference, missense, utr-variant-5-prime
VAR_063501 Esophagus cancer sample
VAR_063502 Esophagus cancer sample
VAR_063503 Esophagus cancer samples
VAR_063504 Esophagus cancer samples

Structural Variations from Database of Genomic Variants (DGV) for FBXO4 Gene

Variant ID Type Subtype PubMed ID
dgv1096e214 CNV gain 21293372
esv2762518 CNV loss 21179565
esv3604851 CNV gain 21293372
nsv830272 CNV gain 17160897
nsv830273 CNV gain 17160897

Variation tolerance for FBXO4 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO4 Gene

Disorders for FBXO4 Gene

Relevant External Links for FBXO4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO4

No disorders were found for FBXO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO4 Gene

Publications for FBXO4 Gene

  1. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. (PMID: 20181953) Li Y. … Hao B. (J. Biol. Chem. 2010) 3 4 22 64
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  3. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 64
  4. Structural basis of selective ubiquitination of TRF1 by SCFFbx4. (PMID: 20159592) Zeng Z. … Lei M. (Dev. Cell 2010) 3 4 64
  5. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. (PMID: 18598945) Barbash O. … Diehl J.A. (Cancer Cell 2008) 3 4 64

Products for FBXO4 Gene

Sources for FBXO4 Gene

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