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Aliases for FBXO4 Gene

Aliases for FBXO4 Gene

  • F-Box Protein 4 2 3
  • FBX4 3 4 6
  • F-Box Only Protein 4 2 3
  • F-Box Protein Fbx4 3

External Ids for FBXO4 Gene

Previous GeneCards Identifiers for FBXO4 Gene

  • GC05P042223
  • GC05P043025
  • GC05P041970
  • GC05P041961
  • GC05P041878

Summaries for FBXO4 Gene

Entrez Gene Summary for FBXO4 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FBXO4 Gene

FBXO4 (F-Box Protein 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO4 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Gene Wiki entry for FBXO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO4 Gene

Genomics for FBXO4 Gene

Regulatory Elements for FBXO4 Gene

Genomic Location for FBXO4 Gene

Start:
41,925,252 bp from pter
End:
41,941,743 bp from pter
Size:
16,492 bases
Orientation:
Plus strand

Genomic View for FBXO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO4 Gene

Proteins for FBXO4 Gene

  • Protein details for FBXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT5-FBX4_HUMAN
    Recommended name:
    F-box only protein 4
    Protein Accession:
    Q9UKT5
    Secondary Accessions:
    • Q68CU8
    • Q86VT8
    • Q9UK98

    Protein attributes for FBXO4 Gene

    Size:
    387 amino acids
    Molecular mass:
    44136 Da
    Quaternary structure:
    • Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1. This interaction is prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1.

    Three dimensional structures from OCA and Proteopedia for FBXO4 Gene

    Alternative splice isoforms for FBXO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO4 Gene

Proteomics data for FBXO4 Gene at MOPED

Post-translational modifications for FBXO4 Gene

  • Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO4 Gene

No data available for DME Specific Peptides for FBXO4 Gene

Domains for FBXO4 Gene

Gene Families for FBXO4 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKT5

UniProtKB/Swiss-Prot:

FBX4_HUMAN :
  • Q9UKT5
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO4: view

Function for FBXO4 Gene

Molecular function for FBXO4 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Gene Ontology (GO) - Molecular Function for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 10531035
GO:0005515 protein binding IPI 16275645
GO:0042803 protein homodimerization activity IPI 20181953
genes like me logo Genes that share ontologies with FBXO4: view
genes like me logo Genes that share phenotypes with FBXO4: view

Animal Models for FBXO4 Gene

MGI Knock Outs for FBXO4:

miRNA for FBXO4 Gene

miRTarBase miRNAs that target FBXO4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FBXO4 Gene

Localization for FBXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO4 Gene COMPARTMENTS Subcellular localization image for FBXO4 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 10531035
GO:0005737 cytoplasm IEA --
GO:0019005 SCF ubiquitin ligase complex IDA 20181953
genes like me logo Genes that share ontologies with FBXO4: view

Pathways for FBXO4 Gene

genes like me logo Genes that share pathways with FBXO4: view

UniProtKB/Swiss-Prot Q9UKT5-FBX4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 16275645
GO:0000723 telomere maintenance IMP 16275645
GO:0006511 ubiquitin-dependent protein catabolic process IDA 16275645
GO:0016567 protein ubiquitination IDA 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 20159592
genes like me logo Genes that share ontologies with FBXO4: view

Transcripts for FBXO4 Gene

Unigene Clusters for FBXO4 Gene

F-box protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for FBXO4 Gene

GeneLoc Exon Structure for
FBXO4
ECgene alternative splicing isoforms for
FBXO4

Expression for FBXO4 Gene

mRNA expression in normal human tissues for FBXO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO4 Gene

SOURCE GeneReport for Unigene cluster for FBXO4 Gene Hs.165575

genes like me logo Genes that share expressions with FBXO4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO4 Gene

Orthologs for FBXO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO4 35
  • 98.89 (n)
  • 99.33 (a)
FBXO4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO4 35
  • 90.61 (n)
  • 90.7 (a)
FBXO4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO4 35
  • 91.3 (n)
  • 89.92 (a)
FBXO4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo4 35
  • 85.89 (n)
  • 88.57 (a)
Fbxo4 16
Fbxo4 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO4 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO4 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo4 35
  • 86.06 (n)
  • 88.57 (a)
chicken
(Gallus gallus)
Aves FBXO4 35
  • 67.57 (n)
  • 61.35 (a)
FBXO4 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO4 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24187 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo4 35
  • 61.4 (n)
  • 58.31 (a)
Str.20453 35
zebrafish
(Danio rerio)
Actinopterygii FBXO4 36
  • 43 (a)
OneToOne
si:dkey-46a10.2 35
  • 55.52 (n)
  • 48.61 (a)
Species with no ortholog for FBXO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO4 Gene

ENSEMBL:
Gene Tree for FBXO4 (if available)
TreeFam:
Gene Tree for FBXO4 (if available)

Paralogs for FBXO4 Gene

No data available for Paralogs for FBXO4 Gene

Variants for FBXO4 Gene

Sequence variations from dbSNP and Humsavar for FBXO4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs277413 -- 41,931,956(-) ttcat(G/T)ttctc intron-variant
rs277414 -- 41,927,321(-) CAGGA(C/T)TAACT intron-variant
rs277415 -- 41,926,362(-) tctcc(C/T)gacct intron-variant
rs277416 -- 41,926,198(-) TGCAG(C/T)TTTCA intron-variant
rs2231910 -- 41,924,847(+) GGAAA(C/T)AACAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXO4 Gene

Variant ID Type Subtype PubMed ID
nsv830272 CNV Gain 17160897
nsv830273 CNV Gain 17160897

Relevant External Links for FBXO4 Gene

HapMap Linkage Disequilibrium report
FBXO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO4 Gene

Disorders for FBXO4 Gene

No disorders were found for FBXO4 Gene.

No data available for UniProtKB/Swiss-Prot for FBXO4 Gene

Publications for FBXO4 Gene

  1. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. (PMID: 20181953) Li Y. … Hao B. (J. Biol. Chem. 2010) 3 4 23
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  3. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4
  4. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FBXO4 Gene

Sources for FBXO4 Gene

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