Aliases for FBXO4 Gene
External Ids for FBXO4 Gene
- HGNC: 13583
- Entrez Gene: 26272
- Ensembl: ENSG00000151876
- OMIM: 609090
- UniProtKB: Q9UKT5
Previous GeneCards Identifiers for FBXO4 Gene
- GC05P042223
- GC05P043025
- GC05P041970
- GC05P041961
- GC05P041878
Summaries for FBXO4 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for FBXO4 Gene
FBXO4 (F-Box Protein 4) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXO4 Gene
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO4 Gene
Genomics for FBXO4 Gene
Regulatory Elements for FBXO4 Gene
Enhancers for FBXO4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G041903 | 1.2 | ENCODE | 34.4 | -20.8 | -20770 | 2.5 | CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZFP41 | FBXO4 SERBP1P6 OXCT1-AS1 CCDC152 C5orf51 PIR36450 GC05P041922 |
| GH05G041869 | 1.1 | ENCODE | 29 | -54.9 | -54943 | 2.6 | HDGF CREB3L1 AGO1 SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 ZNF263 | FBXO4 C5orf51 OXCT1 OXCT1-AS1 |
| GH05G041924 | 1.2 | ENCODE | 10.6 | +0.0 | 19 | 2.1 | CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D | OXCT1 C5orf51 FBXO4 RPSAP38 |
| GH05G041856 | 1 | FANTOM5 ENCODE | 11 | -68.4 | -68409 | 0.2 | HDGF CTCF ESRRA KLF1 RB1 RAD21 RFX5 SCRT2 ZNF143 SMC3 | FBXO4 C5orf51 LOC102723752 GC05M041733 |
| GH05G041871 | 1 | Ensembl ENCODE | 10.8 | -53.4 | -53380 | 0.4 | ZBTB21 INSM2 ZNF101 ZNF302 ZNF366 PRDM10 KLF8 ZBTB20 ZNF10 ZEB2 | C5orf51 FBXO4 OXCT1 RPS2P22 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXO4 Gene
- Chromosome:
- 5
- Start:
- 41,925,252 bp from pter
- End:
- 42,040,228 bp from pter
- Size:
- 114,977 bases
- Orientation:
- Plus strand
Genomic View for FBXO4 Gene
Genes around FBXO4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.1 by Ensembl
- 5p13.1 by Entrez Gene
- 5p13.1 by HGNC
FBXO4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO4 Gene
Proteins for FBXO4 Gene
-
Protein details for FBXO4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKT5-FBX4_HUMAN
- Recommended name:
- F-box only protein 4
- Protein Accession:
- Q9UKT5
- Q68CU8
- Q86VT8
- Q9UK98
Protein attributes for FBXO4 Gene
- Size:
- 387 amino acids
- Molecular mass:
- 44136 Da
- Quaternary structure:
-
- Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1. This interaction is prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1.
Protein Expression for FBXO4 Gene
Post-translational modifications for FBXO4 Gene
- Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FBXO4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO4
- Novus Biologicals Antibodies for FBXO4
-
Abcam antibodies for FBXO4
- Invitrogen Antibodies for FBXO4
- antibodies-online Antibodies for FBXO4: See all 83
- GeneTex FBXO4 antibody for FBXO4
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXO4
Protein Products
-
OriGene Purified Proteins for FBXO4
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXO4
- Origene Custom Protein Services for FBXO4
- antibodies-online Proteins for FBXO4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO4
-
Abcam proteins for FBXO4
Assay Products
- antibodies-online Kits for FBXO4: See all 15
No data available for DME Specific Peptides for FBXO4 Gene
Domains & Families for FBXO4 Gene
Gene Families for FBXO4 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FBXO4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO4 Gene
Function for FBXO4 Gene
Molecular function for FBXO4 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 16278047 |
| GO:0042803 | protein homodimerization activity | IPI | 20181953 |
| GO:0061630 | ubiquitin protein ligase activity | IEA | -- |
Phenotypes for FBXO4 Gene
- MGI mutant phenotypes for FBXO4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FBXO4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO4 gene
- Search ViGene Biosciences for FBXO4
CRISPR Products
-
OriGene CRISPR knockouts for FBXO4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO4
- GenScript: Design CRISPR guide RNA sequences for FBXO4
miRNA for FBXO4 Gene
- miRTarBase miRNAs that target FBXO4
miRNA Products
- Search ViGene Biosciences for FBXO4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXO4
- Browse OriGene Inhibitory RNA Products For FBXO4
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO4 gene
Cell Line Products
-
Horizon Cell Lines for FBXO4
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO4 Gene
Localization for FBXO4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXO4 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IDA | 10531035 |
| GO:0005737 | cytoplasm | IDA | 21378169 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 20181953 |
Pathways & Interactions for FBXO4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Chaperonin-mediated protein folding |
.94
|
|
| 3 | Ubiquitin mediated proteolysis | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | Metabolism of proteins | ||
Pathways by source for FBXO4 Gene
1 KEGG pathway for FBXO4 Gene
UniProtKB/Swiss-Prot Q9UKT5-FBX4_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXO4 Gene
Selected Interacting proteins:
ENSP00000281623
Q9UKT5-FBX4_HUMAN
for FBXO4 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0010608 | posttranscriptional regulation of gene expression | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA,TAS | 24389012 |
| GO:0019725 | cellular homeostasis | IEA | -- |
Transcripts for FBXO4 Gene
mRNA/cDNA for FBXO4 Gene
- (6) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (85) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO4
- GenScript: Design CRISPR guide RNA sequences for FBXO4
miRNA Products
- Search ViGene Biosciences for FBXO4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXO4
- Browse OriGene Inhibitory RNA Products For FBXO4
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO4 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: | - | - |
Expression for FBXO4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
- Neural Ectoderm (Nervous System)
- Neural Tube (Nervous System)
This gene is overexpressed in Stomach (11.6), CD8 Tcells (9.9), Testis (9.6), and Ovary (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO4 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO4 Gene:
FBXO4SOURCE GeneReport for Unigene cluster for FBXO4 Gene:
Hs.165575Evidence on tissue expression from TISSUES for FBXO4 Gene
- Liver(4.1)
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for FBXO4
-
OriGene qPCR primer pairs and template standards for FBXO4
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO4 Gene
Orthologs for FBXO4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO4 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO4 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fbxo4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo4 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo4 34 |
|
||
| Str.20453 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24187 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-46a10.2 34 |
|
||
| FBXO4 35 |
|
OneToOne |
- Species where no ortholog for FBXO4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO4 Gene
No data available for Paralogs for FBXO4 Gene
Variants for FBXO4 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2231917 | Esophagus cancer samples | 41,925,333(+) | CGCAG(C/G)GGAAC | upstream-variant-2KB, reference, missense, utr-variant-5-prime | |
| VAR_063501 | Esophagus cancer sample | ||||
| VAR_063502 | Esophagus cancer sample | ||||
| VAR_063503 | Esophagus cancer samples | ||||
| VAR_063504 | Esophagus cancer samples |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1096e214 | CNV | gain | 21293372 |
| esv2762518 | CNV | loss | 21179565 |
| esv3604851 | CNV | gain | 21293372 |
| nsv830272 | CNV | gain | 17160897 |
| nsv830273 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.61;
45.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO4 Gene
Disorders for FBXO4 Gene
Relevant External Links for FBXO4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXO4
No disorders were found for FBXO4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO4 Gene
Publications for FBXO4 Gene
- Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. (PMID: 20181953) Li Y. … Hao B. (J. Biol. Chem. 2010) 3 4 22 64
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
- A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 64
- Structural basis of selective ubiquitination of TRF1 by SCFFbx4. (PMID: 20159592) Zeng Z. … Lei M. (Dev. Cell 2010) 3 4 64
- Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. (PMID: 18598945) Barbash O. … Diehl J.A. (Cancer Cell 2008) 3 4 64
Products for FBXO4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FBXO4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FBXO4
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXO4
- Origene Custom Protein Services for FBXO4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO4
- Browse OriGene Inhibitory RNA Products For FBXO4
- OriGene qPCR primer pairs and template standards for FBXO4
- OriGene qPCR primer pairs for FBXO4
- OriGene CRISPR knockouts for FBXO4
- OriGene ORF clones in human for FBXO4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FBXO4
- GenScript: Next-day shipping cDNA ORF clone for FBXO4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FBXO4
- GenScript Custom Assay Services for FBXO4
- GenScript Custom overexpressing Cell Line Services for FBXO4
- GenScript: Design CRISPR guide RNA sequences for FBXO4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FBXO4
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FBXO4
- Novus Biologicals proteins and lysates for FBXO4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FBXO4
- Abcam proteins for FBXO4
- Search for Assays for FBXO4 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for FBXO4: See all 83
- antibodies-online Kits for FBXO4: See all 15
- antibodies-online Proteins for FBXO4: See all 5
- Search antibodies-online for peptides
- GeneTex FBXO4 antibody for FBXO4
- Search GeneTex for Proteins for FBXO4
- ViGene Biosciences adenoviral particle packaged cDNA for FBXO4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXO4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FBXO4 gene
- Search ViGene Biosciences for FBXO4
- Santa Cruz Biotechnology (SCBT) Antibodies for FBXO4
- Search Santa Cruz Biotechnology (SCBT) for FBXO4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FBXO4
- Horizon Cell Lines for FBXO4
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXO4
- VectorBuilder custom plasmid, inducible vectors for FBXO4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer