Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXO4 Gene

protein-coding   GIFtS: 55
GCID: GC05P041925

F-Box Protein 4

(Previous name: F-box only protein 4)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box Protein 41 2
FBX42 3 5
F-Box Only Protein 41 2
F-Box Protein Fbx42

External Ids:    HGNC: 135831   Entrez Gene: 262722   Ensembl: ENSG000001518767   OMIM: 6090905   UniProtKB: Q9UKT53   

Export aliases for FBXO4 gene to outside databases

Previous GC identifers: GC05P042223 GC05P043025 GC05P041970 GC05P041961 GC05P041878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXO4 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for FBXO4 Gene:
FBXO4 (F-box protein 4) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes
ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its
ubiquitination together with UBE2D1

Gene Wiki entry for FBXO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO4 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   GATA-1   MEF-2A   Nkx3-1 v2   Nkx3-1 v3   aMEF-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO4 promoter sequence
   Search Chromatin IP Primers for FBXO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p12

FBXO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P041925:  view genomic region     (about GC identifiers)

Start:
41,925,356 bp from pter      End:
41,941,845 bp from pter
Size:
16,490 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5 (See protein sequence)
Recommended Name: F-box only protein 4  
Size: 387 amino acids; 44136 Da
Subunit: Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein
ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1. This interaction is
prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1
2 PDB 3D structures from and Proteopedia for FBXO4:
3L2O (3D)        3L82 (3D)    
Secondary accessions: Q68CU8 Q86VT8 Q9UK98
Alternative splicing: 2 isoforms:  Q9UKT5-1   Q9UKT5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO4: NX_Q9UKT5

Explore proteomics data for FBXO4 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the
    G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation
    at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036308.1  NP_277019.1  

    ENSEMBL proteins: 
     ENSP00000424750   ENSP00000296812   ENSP00000281623   ENSP00000424991   ENSP00000421749  
    Reactome Protein details: Q9UKT5

    FBXO4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for FBXO4
    OriGene Protein Over-expression Lysate for FBXO4
    OriGene MassSpec for FBXO4
    OriGene Custom Protein Services for FBXO4
    GenScript Custom Purified and Recombinant Proteins Services for FBXO4
    Novus Biologicals FBXO4 Protein
    Novus Biologicals FBXO4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO4

     
    Search eBioscience for Proteins for FBXO4 

    FBXO4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FBXO4
    OriGene Custom Antibody Services for FBXO4
    Novus Biologicals FBXO4 Antibodies
    Abcam antibodies for FBXO4
    Cloud-Clone Corp. Antibodies for FBXO4
    ThermoFisher Antibodies for FBXO4
    LSBio Antibodies in human, mouse, rat for FBXO4

    FBXO4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXO4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXO4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXO4
    Cloud-Clone Corp. CLIAs for FBXO4
    Search eBioscience for ELISAs for FBXO4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKT5

    ProtoNet protein and cluster: Q9UKT5

    UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX4_HUMAN, Q9UKT5
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes
    ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its
    ubiquitination together with UBE2D1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA10531035
    GO:0005515protein binding IPI16275645
    GO:0042803protein homodimerization activity IPI--
         
    Find genes that share ontologies with FBXO4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO4:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fbxo4):
     cellular  hematopoietic system  immune system  mortality/aging  normal 
     tumorigenesis 

    Find genes that share phenotypes with FBXO4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fbxo4tm1.1Jadi for FBXO4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO4

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXO4:
    hsa-mir-192-5p (MIRT026787), hsa-mir-215-5p (MIRT024311)

    Block miRNA regulation of human, mouse, rat FBXO4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FBXO4:
    hsa-miR-3163 hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidFBXO4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO4
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXO4

    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO4 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO4 (NM_001080469)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXO4
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FBX4_HUMAN, Q9UKT5: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA10531035
    GO:0005737cytoplasm IEA--
    GO:0019005SCF ubiquitin ligase complex IDA--

    Find genes that share ontologies with FBXO4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FBXO4 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FBXO4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for FBXO4
        Association of TriC/CCT with target proteins during biosynthesis
    Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for FBXO4):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO4: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FBXO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO4 (Q9UKT51, 2, 3 ENSP000002816234) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136161, 2, 3, ENSP000003268044EBI-960409,EBI-359390 MINT-8399492 I2D: score=3 STRING: ENSP00000326804
    TERF1P542741, 3, ENSP000002766034EBI-960421,EBI-710997 I2D: score=2 STRING: ENSP00000276603
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    SKP1P632083, ENSP000002314874I2D: score=5 STRING: ENSP00000231487
    CCND1P243853, ENSP000002275074I2D: score=1 STRING: ENSP00000227507
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16275645
    GO:0000723telomere maintenance IMP16275645
    GO:0006511ubiquitin-dependent protein catabolic process IDA16275645
    GO:0016567protein ubiquitination IDA10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA--

    Find genes that share ontologies with FBXO4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO4 (FBX4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBXO4 gene (2 alternative transcripts): 
    NM_012176.2  NM_033484.2  

    Unigene Cluster for FBXO4:

    F-box protein 4
    Hs.165575  [show with all ESTs]
    Unigene Representative Sequence: NM_033484
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513496 ENST00000296812(uc003jmp.3) ENST00000281623(uc003jmq.3)
    ENST00000504463 ENST00000509134 ENST00000506496 ENST00000505566
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXO4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate FBXO4:
    hsa-miR-3163 hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidFBXO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO4
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO4
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO4 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO4 (NM_001080469)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXO4
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO4
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO4
      QuantiFast Probe-based Assays in human, mouse, rat FBXO4

    Additional mRNA sequence: 

    AF129534.1 AF176703.1 AK024075.1 BC040011.1 BC048098.1 CR749719.1 

    11 DOTS entries:

    DT.40129982  DT.92063907  DT.100766311  DT.120840942  DT.40197874  DT.92424500  DT.95270391  DT.100766309 
    DT.91820447  DT.101981466  DT.110039 

    Selected AceView cDNA sequences (see all 85):

    CR749719 AK024075 AI961240 NM_012176 AW151742 AI379116 BG942675 AI141317 
    BC048098 AK001003 AI718802 BU192331 AA150283 BI761606 AW262991 AU143782 
    CF265110 AW338468 AA419448 BC040011 BM799980 CB851560 CR600197 BF437641 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXO4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
    SP1:                          -           -                             -     -               
    SP2:                          -           -                                                   
    SP3:                    -     -           -                                                   
    SP4:                                                                                          
    SP5:                                                                    -                     


    ECgene alternative splicing isoforms for FBXO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBXO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGTCCAG
    FBXO4 Expression
    About this image


    FBXO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    FBXO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.165575
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO4: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXO4
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO4
    QuantiTect SYBR Green Assays in human, mouse, rat FBXO4
    QuantiFast Probe-based Assays in human, mouse, rat FBXO4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo41 , 5 F-box protein 41, 5 85.89(n)1
    88.57(a)1
      15 (1.84 cM)5
    1060521  NM_134099.21  NP_598860.21 
     39654455 
    chicken
    (Gallus gallus)
    Aves FBXO41 F-box protein 4 67.57(n)
    61.35(a)
      431586  XM_429141.4  XP_429141.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO46
    F-box protein 4
    50(a)
    1 ↔ 1
    2(6561034-6573776)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241872 Xenopus laevis transcribed sequence with weak similarity more 73.8(n)    CF546664.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-46a10.21 si:dkey-46a10.2 55.52(n)
    48.61(a)
      100319387  XM_002663139.3  XP_002663185.3 


    ENSEMBL Gene Tree for FBXO4 (if available)
    TreeFam Gene Tree for FBXO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBXO4 (see all 345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22319171,2,,4
    CEsophagus cancer samples4 --41925435(+) CGCAGC/GGGAAC 4 S R mis1 ese30--------
    VAR_0635024
    Esophagus cancer sample4--see VAR_0635022 P S mis40--------
    VAR_0635044
    Esophagus cancer samples4--see VAR_0635042 P T mis40--------
    VAR_0635034
    Esophagus cancer samples4--see VAR_0635032 L Q mis40--------
    VAR_0635014
    Esophagus cancer sample4--see VAR_0635012 S L mis40--------
    rs1911710131,2
    --41923435(+) AATTAG/TAGAAC 2 -- us2k10--------
    rs104732551,2
    C,F,A,H--41923495(+) ATGCTC/GTATCT 2 -- us2k17Minor allele frequency- G:0.10NS EA CSA WA NA 652
    rs1433994211,2
    C--41923520(+) TTACAG/TGAAAT 2 -- us2k10--------
    rs1822585531,2
    --41923598(+) TTTCAG/TTCTCA 2 -- us2k10--------
    rs1867463431,2
    --41923615(+) AATACA/CATTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO4 (41925356 - 41941845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830272CNV Gain17160897
    nsv830273CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO4
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609090    OMIM disorders: --


    Find genes that share disorders with FBXO4           About GenesLikeMe


    Export disorders for FBXO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBXO4 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with FBXO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    3. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. (PubMed id 20181953)1, 2, 9 Li Y. and Hao B. (J. Biol. Chem. 2010)
    4. Structural basis of selective ubiquitination of TRF1 by SCFFbx4. (PubMed id 20159592)1, 2 Zeng Z....Lei M. (Dev. Cell 2010)
    5. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. (PubMed id 18598945)1, 2 Barbash O.... Diehl J.A. (Cancer Cell 2008)
    6. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. (PubMed id 16275645)1, 2 Lee T.H.... Zhou X.Z. (J. Biol. Chem. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PubMed id 10828603)1, 9 Chiaur D.S....Pagano M. (Cytogenet. Cell Genet. 2000)
    9. The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. (PubMed id 24019069)1 Lee E.K....Diehl J.A. (Mol. Cell. Biol. 2013)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26272 HGNC: 13583 AceView: FBXO4 Ensembl:ENSG00000151876 euGenes: HUgn26272
    ECgene: FBXO4 Kegg: 26272 H-InvDB: FBXO4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBXO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBXO4 gene:
    Search GeneIP for patents involving FBXO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FBXO4   OriGene RNAi products in human, mouse, rat for FBXO4  
     OriGene qPCR primer pairs and template standards for FBXO4   OriGene Protein Over-expression Lysate for FBXO4  
     OriGene MassSpec something-or-other for FBXO4   OriGene clones in human, mouse for FBXO4  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXO4   OriGene Purified Protein for FBXO4  
     OriGene ORF clones in mouse, rat for FBXO4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXO4   OriGene Custom Protein Services for FBXO4  

     
     
     Block miRNA regulation of human, mouse, rat FBXO4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXO4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO4 Predesigned siRNA for gene silencing in human, mouse, rat FBXO4
     QuantiFast Probe-based Assays in human, mouse, rat FBXO4 QuantiTect SYBR Green Assays in human, mouse, rat FBXO4
     PCR Arrays including human, mouse, rat FBXO4 Search Chromatin IP Primers for FBXO4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO4  GeneGlobe Interaction Network for FBXO4
     Regulatory tfbs in FBXO4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBXO4 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO4
     GenScript Custom Assay Services for FBXO4 GenScript Custom overexpressing Cell Line Services for FBXO4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBXO4 (FBX4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBXO4 antibodies
     FBXO4 proteins
     FBXO4 lysates
     Antibodies for FBXO4
     See all of Abcam's Antibodies, Kits and Proteins for FBXO4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBXO4
     Antibodies for FBXO4
     ELISAs for FBXO4
     CLIAs for FBXO4



     Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO4
     SwitchGear 3'UTR luciferase reporter plasmids for FBXO4
     SwitchGear Promoter luciferase reporter plasmids for FBXO4
     ThermoFisher Antibodies for FBXO4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO4
     LSBio Antibodies in human, mouse, rat for FBXO4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FBXO4
      Search eBioscience for proteins for FBXO4
      Search eBioscience for elisas for FBXO4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXO4 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4