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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO4 Gene

protein-coding   GIFtS: 54
GCID: GC05P041925

F-Box Protein 4

(Previous name: F-box only protein 4)
  Search for FBXO4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 41 2
FBX42 3 5
F-Box Only Protein 41 2
F-Box Protein Fbx42

External Ids:    HGNC: 135831   Entrez Gene: 262722   Ensembl: ENSG000001518767   OMIM: 6090905   UniProtKB: Q9UKT53   

Export aliases for FBXO4 gene to outside databases

Previous GC identifers: GC05P042223 GC05P043025 GC05P041970 GC05P041961 GC05P041878


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO4 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for FBXO4 Gene: 
FBXO4 (F-box protein 4) is a protein-coding gene. Among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Chaperonin-mediated protein folding. GO annotations related to this gene include ubiquitin-protein ligase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes
ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its
ubiquitination together with UBE2D1

Gene Wiki entry for FBXO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO4 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   GATA-1   MEF-2A   Nkx3-1 v2   Nkx3-1 v3   aMEF-2   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p12

FBXO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P041925:  view genomic region     (about GC identifiers)

Start:
41,925,356 bp from pter      End:
41,941,845 bp from pter
Size:
16,490 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5 (See protein sequence)
Recommended Name: F-box only protein 4  
Size: 387 amino acids; 44136 Da
Subunit: Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein
ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1. This interaction is
prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1
Subcellular location: Cytoplasm (By similarity)
2 PDB 3D structures from and Proteopedia for FBXO4:
3L2O (3D)        3L82 (3D)    
Secondary accessions: Q68CU8 Q86VT8 Q9UK98
Alternative splicing: 2 isoforms:  Q9UKT5-1   Q9UKT5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO4: NX_Q9UKT5

Explore proteomics data for FBXO4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the
    G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation
    at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKT5

  • FBXO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036308.1  NP_277019.1  

    ENSEMBL proteins: 
     ENSP00000424750   ENSP00000296812   ENSP00000281623   ENSP00000424991   ENSP00000421749  
    Reactome Protein details: Q9UKT5
    Human Recombinant Protein Products for FBXO4: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA10531035
    GO:0005737cytoplasm IEA--
    GO:0019005SCF ubiquitin ligase complex IDA--

    FBXO4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9UKT5

    ProtoNet protein and cluster: Q9UKT5

    UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5
    Similarity: Contains 1 F-box domain


    FBXO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX4_HUMAN, Q9UKT5
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes
    ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its
    ubiquitination together with UBE2D1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA10531035
    GO:0005515protein binding IPI16275645
    GO:0042803protein homodimerization activity IPI--
         
    FBXO4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO4:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fbxo4):
     cellular  hematopoietic system  immune system  mortality/aging  normal 
     tumorigenesis 

    FBXO4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fbxo4tm1.1Jadi for FBXO4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO4 
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXO4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for FBXO4 (see all 8)
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Antigen processing: Ubiquitination & Proteasome degradation
    Metabolism of proteins
    Protein folding


    1         Kegg Pathway  (Kegg details for FBXO4):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: FBX4_HUMAN, Q9UKT5
    Pathway: Protein modification; protein ubiquitination


    FBXO4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for FBXO4 (Q9UKT51, 2, 3 ENSP000002816234) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136162, 3, ENSP000003268044MINT-8399492 I2D: score=3 STRING: ENSP00000326804
    TERF1P542741, 3, ENSP000002766034EBI-960421,EBI-710997 I2D: score=2 STRING: ENSP00000276603
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    SKP1P632083, ENSP000002314874I2D: score=5 STRING: ENSP00000231487
    CCND1P243853, ENSP000002275074I2D: score=1 STRING: ENSP00000227507
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16275645
    GO:0000723telomere maintenance IMP16275645
    GO:0006511ubiquitin-dependent protein catabolic process IDA16275645
    GO:0016567protein ubiquitination IDA10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA--

    FBXO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FBXO4 (FBX4)

    Search CenterWatch for drugs/clinical trials and news about FBXO4 / FBX4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO4 gene (2 alternative transcripts): 
    NM_012176.2  NM_033484.2  

    Unigene Cluster for FBXO4:

    F-box protein 4
    Hs.165575  [show with all ESTs]
    Unigene Representative Sequence: NM_033484
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513496 ENST00000296812(uc003jmp.3) ENST00000281623(uc003jmq.3)
    ENST00000504463 ENST00000509134 ENST00000506496 ENST00000505566
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO4:
    hsa-miR-3163 hsa-miR-607
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    Additional mRNA sequence: 

    AF129534.1 AF176703.1 AK024075.1 BC040011.1 BC048098.1 CR749719.1 

    11 DOTS entries:

    DT.40129982  DT.92063907  DT.100766311  DT.120840942  DT.40197874  DT.92424500  DT.95270391  DT.100766309 
    DT.91820447  DT.101981466  DT.110039 

    24/85 AceView cDNA sequences (see all 85):

    AK024075 BU192331 BI761606 AW262991 AK001003 BF437641 AW268151 AA419448 
    AI379116 BE018131 BF589419 BE220891 BM799980 AA150385 BC040011 AI141317 
    CB851560 AA832485 AA150283 AI961240 CR749719 BI222327 AI718802 CF265110 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
    SP1:                          -           -                             -     -               
    SP2:                          -           -                                                   
    SP3:                    -     -           -                                                   
    SP4:                                                                                          
    SP5:                                                                    -                     


    ECgene alternative splicing isoforms for FBXO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO4 expression in normal human tissues (normalized intensities)      FBXO4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGTCCAG
    FBXO4 Expression
    About this image


    FBXO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Conventional Dendritic Cells I Spleen
             b cells   
     
     Adipose (Muscoskeletal System)
             epididymal fat pads   
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    See FBXO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO4

    SOURCE GeneReport for Unigene cluster: Hs.165575
        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO4: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO4 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo41 , 5 F-box protein 41, 5 85.89(n)1
    88.57(a)1
      15 (1.84 cM)5
    1060521  NM_134099.21  NP_598860.21 
     39654455 
    chicken
    (Gallus gallus)
    Aves FBXO41 F-box protein 4 67.94(n)
    61.85(a)
      431586  XM_429141.3  XP_429141.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO46
    Uncharacterized protein
    48(a)
    1 ↔ 1
    2(6561034-6573776)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241872 Xenopus laevis transcribed sequence with weak similarity more 73.8(n)    CF546664.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-46a10.21 si:dkey-46a10.2 51.74(n)
    49.08(a)
      100319387  XM_002663139.2  XP_002663185.2 


    ENSEMBL Gene Tree for FBXO4 (if available)
    TreeFam Gene Tree for FBXO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/345 SNPs in FBXO4 are shown (see all 345)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0635024
    Esophagus cancer sample4--see VAR_0635022 P S mis40--------
    VAR_0635044
    Esophagus cancer samples4--see VAR_0635042 P T mis40--------
    VAR_0635034
    Esophagus cancer samples4--see VAR_0635032 L Q mis40--------
    VAR_0635014
    Esophagus cancer sample4--see VAR_0635012 S L mis40--------
    rs22319171,2,4
    CEsophagus cancer samples4 --41925435(+) CGCAGC/GGGAAC 4 S R mis1 ese30--------
    rs1911710131,2
    --41923435(+) AATTAG/TAGAAC 2 -- us2k10--------
    rs104732551,2
    C,F,A,H--41923495(+) ATGCTC/GTATCT 2 -- us2k17Minor allele frequency- G:0.10NS EA CSA WA NA 652
    rs1433994211,2
    C--41923520(+) TTACAG/TGAAAT 2 -- us2k10--------
    rs1822585531,2
    --41923598(+) TTTCAG/TTCTCA 2 -- us2k10--------
    rs1867463431,2
    --41923615(+) AATACA/CATTTA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO4 (41925356 - 41941845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830272CNV Gain17160897
    nsv830273CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXO4 for disorders           About MalaCards
    OMIM gene information: 609090    OMIM disorders: --


    FBXO4 for disorders           About GeneDecksing


    Export disorders for FBXO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with FBXO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    3. Structural basis of dimerization-dependent ubiquitina tion by the SCF(Fbx4) ubiquitin ligase. (PubMed id 20181953)1, 2, 9 Li Y. and Hao B. (2010)
    4. Structural basis of selective ubiquitination of TRF1 by SCFFbx4. (PubMed id 20159592)1, 2 Zeng Z....Lei M. (2010)
    5. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. (PubMed id 18598945)1, 2 Barbash O....Diehl J.A. (2008)
    6. The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. (PubMed id 16275645)1, 2 Lee T.H.... Zhou X.Z. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PubMed id 10828603)1, 9 Chiaur D.S....Pagano M. (2000)
    9. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    10. Characterization of the Cullin7 E3 ubiquitin ligase-- heterodimerization of cullin substrate receptors as a novel mechanism to regula te cullin E3 ligase activity. (PubMed id 21946088)1 Ponyeam W. and Hagen T. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26272 HGNC: 13583 AceView: FBXO4 Ensembl:ENSG00000151876 euGenes: HUgn26272
    ECgene: FBXO4 Kegg: 26272 H-InvDB: FBXO4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO4 gene:
    Search GeneIP for patents involving FBXO4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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