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Aliases for FBXO4 Gene

Aliases for FBXO4 Gene

  • F-Box Protein 4 2 3 5
  • FBX4 3 4
  • F-Box Only Protein 4 2
  • F-Box Protein Fbx4 3

External Ids for FBXO4 Gene

Previous GeneCards Identifiers for FBXO4 Gene

  • GC05P042223
  • GC05P043025
  • GC05P041970
  • GC05P041961
  • GC05P041878

Summaries for FBXO4 Gene

Entrez Gene Summary for FBXO4 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for FBXO4 Gene

FBXO4 (F-Box Protein 4) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include protein homodimerization activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO4 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Gene Wiki entry for FBXO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO4 Gene

Genomics for FBXO4 Gene

Regulatory Elements for FBXO4 Gene

Promoters for FBXO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO4 Gene

Chromosome:
5
Start:
41,925,252 bp from pter
End:
42,040,228 bp from pter
Size:
114,977 bases
Orientation:
Plus strand

Genomic View for FBXO4 Gene

Genes around FBXO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO4 Gene

Proteins for FBXO4 Gene

  • Protein details for FBXO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT5-FBX4_HUMAN
    Recommended name:
    F-box only protein 4
    Protein Accession:
    Q9UKT5
    Secondary Accessions:
    • Q68CU8
    • Q86VT8
    • Q9UK98

    Protein attributes for FBXO4 Gene

    Size:
    387 amino acids
    Molecular mass:
    44136 Da
    Quaternary structure:
    • Homodimer. Directly interacts with SKP1 and CUL1. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1. This interaction is prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1.

    Three dimensional structures from OCA and Proteopedia for FBXO4 Gene

    Alternative splice isoforms for FBXO4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO4 Gene

Proteomics data for FBXO4 Gene at MOPED

Post-translational modifications for FBXO4 Gene

  • Phosphorylation at Ser-12 varies during the cell cycle. It is low in resting cells and high in the S phase and the G2/M phase of the cell cycle. Phosphorylation is decreased during late G1 phase (By similarity). Phosphorylation at Ser-12 promotes homodimerization and is necessary for optimal ubiquitin ligase activity towards CCND1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO4 Gene

Antibody Products

No data available for DME Specific Peptides for FBXO4 Gene

Domains & Families for FBXO4 Gene

Gene Families for FBXO4 Gene

Protein Domains for FBXO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKT5

UniProtKB/Swiss-Prot:

FBX4_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO4: view

Function for FBXO4 Gene

Molecular function for FBXO4 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Gene Ontology (GO) - Molecular Function for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA,TAS --
GO:0042803 protein homodimerization activity IPI 20181953
genes like me logo Genes that share ontologies with FBXO4: view
genes like me logo Genes that share phenotypes with FBXO4: view

Animal Models for FBXO4 Gene

MGI Knock Outs for FBXO4:

Animal Model Products

miRNA for FBXO4 Gene

miRTarBase miRNAs that target FBXO4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO4 Gene

Localization for FBXO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO4 Gene COMPARTMENTS Subcellular localization image for FBXO4 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 20181953
genes like me logo Genes that share ontologies with FBXO4: view

Pathways & Interactions for FBXO4 Gene

genes like me logo Genes that share pathways with FBXO4: view

Pathways by source for FBXO4 Gene

UniProtKB/Swiss-Prot Q9UKT5-FBX4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for FBXO4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FBXO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA,TAS --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 20159592
GO:0031398 positive regulation of protein ubiquitination IDA 16275645
genes like me logo Genes that share ontologies with FBXO4: view

Drugs & Compounds for FBXO4 Gene

No Compound Related Data Available

Transcripts for FBXO4 Gene

Unigene Clusters for FBXO4 Gene

F-box protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6: - -

Relevant External Links for FBXO4 Gene

GeneLoc Exon Structure for
FBXO4
ECgene alternative splicing isoforms for
FBXO4

Expression for FBXO4 Gene

mRNA expression in normal human tissues for FBXO4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO4 Gene

This gene is overexpressed in Stomach (11.6), CD8 Tcells (9.9), Testis (9.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO4 Gene



SOURCE GeneReport for Unigene cluster for FBXO4 Gene Hs.165575

genes like me logo Genes that share expression patterns with FBXO4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXO4 Gene

Orthologs for FBXO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO4 35
  • 90.61 (n)
  • 90.7 (a)
FBXO4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO4 35
  • 91.3 (n)
  • 89.92 (a)
FBXO4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo4 35
  • 85.89 (n)
  • 88.57 (a)
Fbxo4 16
Fbxo4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO4 35
  • 98.89 (n)
  • 99.33 (a)
FBXO4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo4 35
  • 86.06 (n)
  • 88.57 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO4 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO4 35
  • 67.57 (n)
  • 61.35 (a)
FBXO4 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO4 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo4 35
  • 61.4 (n)
  • 58.31 (a)
Str.20453 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24187 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-46a10.2 35
  • 55.52 (n)
  • 48.61 (a)
FBXO4 36
  • 43 (a)
OneToOne
Species with no ortholog for FBXO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO4 Gene

ENSEMBL:
Gene Tree for FBXO4 (if available)
TreeFam:
Gene Tree for FBXO4 (if available)

Paralogs for FBXO4 Gene

No data available for Paralogs for FBXO4 Gene

Variants for FBXO4 Gene

Sequence variations from dbSNP and Humsavar for FBXO4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2231917 Esophagus cancer samples 41,925,333(+) CGCAG(C/G)GGAAC reference, missense, utr-variant-5-prime
VAR_063501 Esophagus cancer sample
VAR_063502 Esophagus cancer sample
VAR_063503 Esophagus cancer samples
VAR_063504 Esophagus cancer samples

Structural Variations from Database of Genomic Variants (DGV) for FBXO4 Gene

Variant ID Type Subtype PubMed ID
nsv830272 CNV Gain 17160897
nsv830273 CNV Gain 17160897

Variation tolerance for FBXO4 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO4 Gene

HapMap Linkage Disequilibrium report
FBXO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO4 Gene

Disorders for FBXO4 Gene

Relevant External Links for FBXO4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO4

No disorders were found for FBXO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO4 Gene

Publications for FBXO4 Gene

  1. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 67
  2. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. (PMID: 20181953) Li Y. … Hao B. (J. Biol. Chem. 2010) 3 23
  3. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 3 23
  4. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3
  5. The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis. (PMID: 24389012) Kim J. … Chung I.K. (Biochem. Biophys. Res. Commun. 2014) 3

Products for FBXO4 Gene

Sources for FBXO4 Gene

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