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Aliases for FBXO39 Gene

Aliases for FBXO39 Gene

  • F-Box Protein 39 2 3 5
  • Fbx39 3 4
  • F-Box Only Protein 39 3
  • CT144 3

External Ids for FBXO39 Gene

Previous GeneCards Identifiers for FBXO39 Gene

  • GC17P006881
  • GC17P006620
  • GC17P006679

Summaries for FBXO39 Gene

Entrez Gene Summary for FBXO39 Gene

  • Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO39 Gene

FBXO39 (F-Box Protein 39) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO39 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO39 Gene

Genomics for FBXO39 Gene

Regulatory Elements for FBXO39 Gene

Enhancers for FBXO39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F006786 1 Ensembl ENCODE 28.9 +10.8 10818 0.9 SAP130 JUN RARA POLR2A CREM GATAD2A ZNF263 HLF FOXA3 CEBPB FBXO39 TEKT1
GH17F007474 1.6 FANTOM5 ENCODE 11.1 +704.4 704415 12.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 DVL2 SNORD10 SNORA48 CHRNB1 PFAS LOC105371523 KCTD11 CTC1 CNTROB MIR6883
GH17F007571 1.2 ENCODE 11.1 +802.0 801984 14.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 DVL2 SNORD10 SNORA48 PFAS LOC105371523 CTC1 CNTROB MIR6883 KCTD11 MIR324
GH17F007439 1 ENCODE 11.1 +664.4 664396 2.1 HDGF PKNOX1 CREB3L1 ARID4B GLI4 ZNF48 GLIS2 ZNF548 SP3 MXD4 LOC105371523 DVL2 PFAS CTC1 SNORD10 CNTROB SNORA48 MIR6883 CHRNB1 FGF11
GH17F006699 1 ENCODE 10.3 -75.6 -75608 1.8 ATF1 MLX ARID4B ZNF48 YY1 SLC30A9 SP5 PPARG KAT8 SSRP1 XAF1 ENSG00000256806 MED31 FBXO39 SLC13A5 GC17M006685
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO39 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO39 Gene

6,776,175 bp from pter
6,797,101 bp from pter
20,927 bases
Plus strand

Genomic View for FBXO39 Gene

Genes around FBXO39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO39 Gene

Proteins for FBXO39 Gene

  • Protein details for FBXO39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 39
    Protein Accession:

    Protein attributes for FBXO39 Gene

    442 amino acids
    Molecular mass:
    52646 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXO39 Gene

Post-translational modifications for FBXO39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO39 Gene

No data available for DME Specific Peptides for FBXO39 Gene

Domains & Families for FBXO39 Gene

Gene Families for FBXO39 Gene

Protein Domains for FBXO39 Gene

Suggested Antigen Peptide Sequences for FBXO39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO39: view

Function for FBXO39 Gene

Molecular function for FBXO39 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXO39: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO39 Gene

Localization for FBXO39 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO39 gene
Compartment Confidence
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FBXO39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with FBXO39: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO39 Gene

Pathways & Interactions for FBXO39 Gene

SuperPathways for FBXO39 Gene

No Data Available

Interacting Proteins for FBXO39 Gene

Selected Interacting proteins: Q8N4B4-FBX39_HUMAN for FBXO39 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FBXO39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with FBXO39: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO39 Gene

Transcripts for FBXO39 Gene

mRNA/cDNA for FBXO39 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO39 Gene

F-box protein 39:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO39 Gene

No ASD Table

Relevant External Links for FBXO39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO39 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO39 Gene

This gene is overexpressed in Testis (x34.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO39 Gene

Protein tissue co-expression partners for FBXO39 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO39 Gene:


SOURCE GeneReport for Unigene cluster for FBXO39 Gene:

genes like me logo Genes that share expression patterns with FBXO39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO39 Gene

Orthologs for FBXO39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO39 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO39 34 35
  • 99.55 (n)
(Bos Taurus)
Mammalia FBXO39 34 35
  • 88.16 (n)
(Canis familiaris)
Mammalia FBXO39 34 35
  • 84.39 (n)
(Rattus norvegicus)
Mammalia Fbxo39 34
  • 84.39 (n)
(Mus musculus)
Mammalia Fbxo39 34 16 35
  • 84.01 (n)
(Ornithorhynchus anatinus)
Mammalia FBXO39 35
  • 73 (a)
(Gallus gallus)
Aves FBXO39 34 35
  • 68.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for FBXO39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO39 Gene

Gene Tree for FBXO39 (if available)
Gene Tree for FBXO39 (if available)

Paralogs for FBXO39 Gene

No data available for Paralogs for FBXO39 Gene

Variants for FBXO39 Gene

Sequence variations from dbSNP and Humsavar for FBXO39 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10401001 -- 6,780,552(+) GTGTC(A/C/T)CTGAA nc-transcript-variant, reference, synonymous-codon
rs10852886 -- 6,789,522(+) CTTCC(A/T)CCCAA intron-variant
rs11078649 -- 6,776,325(+) GTAAC(A/G)GGAGA intron-variant
rs111260698 -- 6,787,238(+) TGTGT(-/AT)GTGTG intron-variant
rs111327661 -- 6,788,229(+) GAAAG(A/G)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO39 Gene

Variant ID Type Subtype PubMed ID
nsv1059072 CNV loss 25217958

Variation tolerance for FBXO39 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.86; 95.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO39 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO39 Gene

Disorders for FBXO39 Gene

Relevant External Links for FBXO39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO39 Gene

Publications for FBXO39 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
  4. Expression Analysis of Two Cancer-testis Genes, FBXO39 and TDRD4, in Breast Cancer Tissues and Cell Lines. (PMID: 24377578) Seifi-Alan M. … Najafi-Ashtiani M. (Asian Pac. J. Cancer Prev. 2013) 3 64
  5. Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX. (PMID: 21338577) Song M.H. … Lee S.Y. (Biochem. Biophys. Res. Commun. 2011) 3 64

Products for FBXO39 Gene

Sources for FBXO39 Gene

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