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Aliases for FBXO39 Gene

Aliases for FBXO39 Gene

  • F-Box Protein 39 2 3 5
  • Fbx39 3 4
  • F-Box Only Protein 39 3
  • CT144 3

External Ids for FBXO39 Gene

Previous GeneCards Identifiers for FBXO39 Gene

  • GC17P006881
  • GC17P006620
  • GC17P006679

Summaries for FBXO39 Gene

Entrez Gene Summary for FBXO39 Gene

  • Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO39 Gene

FBXO39 (F-Box Protein 39) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO39 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXO39 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO39 Gene

Genomics for FBXO39 Gene

GeneHancer (GH) Regulatory Elements for FBXO39 Gene

Promoters and enhancers for FBXO39 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I006776 Promoter 0.7 EPDnew 550.8 +0.0 21 0.1 POLR2A EZH2 FBXO39 PRAL TEKT1
GH17I006786 Enhancer 0.9 Ensembl ENCODE 29 +10.8 10817 0.9 FOXA2 SAP130 ZBTB21 JUN RARA POLR2A CREM GATAD2A FOXA3 HLF FBXO39 TEKT1
GH17I006831 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 13 +55.7 55690 0.8 MXI1 FOXA2 SAP130 ZNF449 MAX ARID4B SIN3A BMI1 THRB RAD21 TEKT1 FBXO39 ALOX12P2
GH17I006853 Promoter/Enhancer 1.6 Ensembl ENCODE 10.6 +78.5 78486 2.7 ELF3 ARID4B SIN3A DMAP1 ZBTB7B THRB ZBTB40 RAD21 YY1 ETS1 ALOX12P2 TEKT1 FBXO39 BCL6B SLC13A5 MIR195 GC17M006868
GH17I006754 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 7.6 -20.1 -20111 2.9 STAT1 REST YY1 RELA POLR2A STAT2 IKZF1 NBN MLLT1 ETV6 XAF1 FBXO39 ACAP1 PRAL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO39 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO39 gene promoter:

Genomic Locations for FBXO39 Gene

Genomic Locations for FBXO39 Gene
20,927 bases
Plus strand

Genomic View for FBXO39 Gene

Genes around FBXO39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO39 Gene

Proteins for FBXO39 Gene

  • Protein details for FBXO39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 39
    Protein Accession:

    Protein attributes for FBXO39 Gene

    442 amino acids
    Molecular mass:
    52646 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXO39 Gene

Post-translational modifications for FBXO39 Gene

No Post-translational modifications

Other Protein References for FBXO39 Gene

No data available for DME Specific Peptides for FBXO39 Gene

Domains & Families for FBXO39 Gene

Gene Families for FBXO39 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO39 Gene

Suggested Antigen Peptide Sequences for FBXO39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO39: view

No data available for UniProtKB/Swiss-Prot for FBXO39 Gene

Function for FBXO39 Gene

Molecular function for FBXO39 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO39 Gene

genes like me logo Genes that share phenotypes with FBXO39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO39 Gene

Localization for FBXO39 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO39 gene
Compartment Confidence
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FBXO39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with FBXO39: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXO39 Gene

Pathways & Interactions for FBXO39 Gene

SuperPathways for FBXO39 Gene

No Data Available

Interacting Proteins for FBXO39 Gene

Gene Ontology (GO) - Biological Process for FBXO39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with FBXO39: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO39 Gene

Drugs & Compounds for FBXO39 Gene

No Compound Related Data Available

Transcripts for FBXO39 Gene

mRNA/cDNA for FBXO39 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO39 Gene

F-box protein 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO39 Gene

No ASD Table

Relevant External Links for FBXO39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO39 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO39 Gene

This gene is overexpressed in Testis (x34.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO39 Gene

Protein tissue co-expression partners for FBXO39 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO39 Gene:


SOURCE GeneReport for Unigene cluster for FBXO39 Gene:


Evidence on tissue expression from TISSUES for FBXO39 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FBXO39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO39 Gene

Orthologs for FBXO39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO39 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO39 33 34
  • 99.55 (n)
(Bos Taurus)
Mammalia FBXO39 33 34
  • 88.16 (n)
(Canis familiaris)
Mammalia FBXO39 33 34
  • 84.39 (n)
(Rattus norvegicus)
Mammalia Fbxo39 33
  • 84.39 (n)
(Mus musculus)
Mammalia Fbxo39 33 16 34
  • 84.01 (n)
(Ornithorhynchus anatinus)
Mammalia FBXO39 34
  • 73 (a)
(Gallus gallus)
Aves FBXO39 33 34
  • 68.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for FBXO39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO39 Gene

Gene Tree for FBXO39 (if available)
Gene Tree for FBXO39 (if available)

Paralogs for FBXO39 Gene

No data available for Paralogs for FBXO39 Gene

Variants for FBXO39 Gene

Sequence variations from dbSNP and Humsavar for FBXO39 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000028121 -- 6,783,413(+) A/G intron_variant
rs1000058173 -- 6,776,708(+) T/C intron_variant
rs1000063722 -- 6,781,709(+) T/C intron_variant
rs1000160957 -- 6,777,194(+) A/G intron_variant
rs1000299392 -- 6,776,904(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO39 Gene

Variant ID Type Subtype PubMed ID
nsv1059072 CNV loss 25217958

Variation tolerance for FBXO39 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.86; 95.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO39 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO39 Gene

Disorders for FBXO39 Gene

Additional Disease Information for FBXO39

No disorders were found for FBXO39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO39 Gene

Publications for FBXO39 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 58
  4. Expression analysis of two cancer-testis genes, FBXO39 and TDRD4, in breast cancer tissues and cell lines. (PMID: 24377578) Seifi-Alan M … Najafi-Ashtiani M (Asian Pacific journal of cancer prevention : APJCP 2014) 3 58
  5. Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX. (PMID: 21338577) Song MH … Lee SY (Biochemical and biophysical research communications 2011) 3 58

Products for FBXO39 Gene

Sources for FBXO39 Gene

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