Aliases for FBXO39 Gene
External Ids for FBXO39 Gene
- HGNC: 28565
- Entrez Gene: 162517
- Ensembl: ENSG00000177294
- OMIM: 609106
- UniProtKB: Q8N4B4
Previous GeneCards Identifiers for FBXO39 Gene
- GC17P006881
- GC17P006620
- GC17P006679
Summaries for FBXO39 Gene
-
Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO39 Gene
FBXO39 (F-Box Protein 39) is a Protein Coding gene.
UniProtKB/Swiss-Prot for FBXO39 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO39 Gene
Genomics for FBXO39 Gene
Regulatory Elements for FBXO39 Gene
Enhancers for FBXO39 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G006786 | 1 | Ensembl ENCODE | 29 | +10.8 | 10818 | 0.9 | FOXA2 SAP130 ZBTB21 JUN RARA POLR2A FOS CREM ZNF263 GATAD2A | FBXO39 TEKT1 |
| GH17G006831 | 1.1 | Ensembl ENCODE | 13 | +55.7 | 55690 | 0.8 | MXI1 FOXA2 SAP130 MAX ARID4B SIN3A BMI1 THRB RAD21 RFX5 | FBXO39 TEKT1 ALOX12P2 |
| GH17G006853 | 1.2 | Ensembl ENCODE | 10.6 | +78.5 | 78487 | 2.7 | ELF3 ARID4B SIN3A DMAP1 THRB RAD21 ZBTB7B ZBTB40 RARA YY1 | TEKT1 FBXO39 BCL6B SLC13A5 MIR195 ALOX12P2 GC17M006868 |
| GH17G006699 | 1 | ENCODE | 10.3 | -75.6 | -75608 | 1.8 | FOXA2 ATF1 MLX ARID4B ZNF48 YY1 TCF12 SLC30A9 SP5 PPARG | XAF1 MED31 C17orf100 FBXO39 SLC13A5 GC17M006685 |
| GH17G006668 | 0.9 | ENCODE | 10.6 | -105.8 | -105846 | 3.2 | ELF3 NFIB KLF17 THRB ZNF48 RARA IKZF2 EGR2 ZBTB2 NCOA1 | SLC13A5 KIAA0753 TXNDC17 FBXO39 TEKT1 BCL6B ENSG00000261996 CTDNEP1 GC17P006673 PIR54331 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO39 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXO39 Gene
- Chromosome:
- 17
- Start:
- 6,776,175 bp from pter
- End:
- 6,797,101 bp from pter
- Size:
- 20,927 bases
- Orientation:
- Plus strand
Genomic View for FBXO39 Gene
Genes around FBXO39 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.1 by HGNC
FBXO39 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO39 Gene
Proteins for FBXO39 Gene
-
Protein details for FBXO39 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N4B4-FBX39_HUMAN
- Recommended name:
- F-box only protein 39
- Protein Accession:
- Q8N4B4
Protein attributes for FBXO39 Gene
- Size:
- 442 amino acids
- Molecular mass:
- 52646 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
Protein Expression for FBXO39 Gene
Post-translational modifications for FBXO39 Gene
Other Protein References for FBXO39 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO39
- Novus Biologicals Antibodies for FBXO39
-
Abcam antibodies for FBXO39
- Invitrogen Antibodies for FBXO39
- antibodies-online Antibodies for FBXO39: See all 27
- GeneTex FBXO39 antibody for FBXO39
Protein Products
-
OriGene Purified Proteins for FBXO39
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXO39
- Origene Custom Protein Services for FBXO39
- antibodies-online Proteins for FBXO39: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO39
-
Abcam proteins for FBXO39
Assay Products
- antibodies-online Kits for FBXO39: See all 15
No data available for DME Specific Peptides for FBXO39 Gene
Domains & Families for FBXO39 Gene
Gene Families for FBXO39 Gene
- HGNC:
Protein Domains for FBXO39 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO39 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO39 Gene
Function for FBXO39 Gene
Molecular function for FBXO39 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Phenotypes for FBXO39 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO39 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO39 gene
- Search ViGene Biosciences for FBXO39
CRISPR Products
-
OriGene CRISPR knockouts for FBXO39
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO39
- GenScript: Design CRISPR guide RNA sequences for FBXO39
miRNA Products
- Search ViGene Biosciences for FBXO39
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO39
- Browse OriGene Inhibitory RNA Products For FBXO39
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO39 gene
Clone Products
-
OriGene ORF clones in human for FBXO39
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Cell Line Products
-
Horizon Cell Lines for FBXO39
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO39 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO39 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO39 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO39 Gene
Localization for FBXO39 Gene
| Compartment | Confidence |
|---|---|
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0019005 | SCF ubiquitin ligase complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO39 Gene
Pathways & Interactions for FBXO39 Gene
No Data Available
Interacting Proteins for FBXO39 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FBXO39 Gene
Transcripts for FBXO39 Gene
mRNA/cDNA for FBXO39 Gene
- (3) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO39
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO39
- GenScript: Design CRISPR guide RNA sequences for FBXO39
miRNA Products
- Search ViGene Biosciences for FBXO39
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO39
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO39 gene
Clone Products
-
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Expression for FBXO39 Gene
mRNA differential expression in normal tissues according to GTEx for FBXO39 Gene
This gene is overexpressed in Testis (x34.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO39 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO39 Gene:
FBXO39SOURCE GeneReport for Unigene cluster for FBXO39 Gene:
Hs.368364Evidence on tissue expression from TISSUES for FBXO39 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXO39
-
OriGene qPCR primer pairs for FBXO39
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO39 Gene
Orthologs for FBXO39 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO39 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO39 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO39 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo39 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo39 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO39 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO39 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXO39 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXO39 Gene
No data available for Paralogs for FBXO39 Gene
Variants for FBXO39 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000028121 | -- | 6,783,413(+) | TAAAG(A/G)TTGGA | intron-variant | |
| rs1000058173 | -- | 6,776,708(+) | TTGTA(C/T)AGCGT | intron-variant | |
| rs1000063722 | -- | 6,781,709(+) | CTGCC(C/T)CCAAA | intron-variant | |
| rs1000160957 | -- | 6,777,194(+) | CCATC(A/G)ACCTG | intron-variant | |
| rs1000299392 | -- | 6,776,904(+) | GCTAC(A/C)CTGCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1059072 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.86;
95.89% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO39 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO39 Gene
Disorders for FBXO39 Gene
Relevant External Links for FBXO39
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXO39
No disorders were found for FBXO39 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO39 Gene
Publications for FBXO39 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
- Expression Analysis of Two Cancer-testis Genes, FBXO39 and TDRD4, in Breast Cancer Tissues and Cell Lines. (PMID: 24377578) Seifi-Alan M. … Najafi-Ashtiani M. (Asian Pac. J. Cancer Prev. 2013) 3 64
- Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX. (PMID: 21338577) Song M.H. … Lee S.Y. (Biochem. Biophys. Res. Commun. 2011) 3 64
Products for FBXO39 Gene
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- Custom Antibody ServicesOriGene Antibodies for FBXO39
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- Novus Biologicals Antibodies for FBXO39
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- antibodies-online Antibodies for FBXO39: See all 27
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- ViGene Biosciences adenoviral particle packaged cDNA for FBXO39 gene
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- Horizon Cell Lines for FBXO39
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXO39
- VectorBuilder custom plasmid, inducible vectors for FBXO39
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO39
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO39 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer