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Aliases for FBXO39 Gene

Aliases for FBXO39 Gene

  • F-Box Protein 39 2 3
  • Fbx39 3 4 6
  • F-Box Only Protein 39 3
  • CT144 3

External Ids for FBXO39 Gene

Previous GeneCards Identifiers for FBXO39 Gene

  • GC17P006881
  • GC17P006620
  • GC17P006679

Summaries for FBXO39 Gene

Entrez Gene Summary for FBXO39 Gene

  • Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO39 Gene

FBXO39 (F-Box Protein 39) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO39 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO39 Gene

Genomics for FBXO39 Gene

Regulatory Elements for FBXO39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO39 Gene

Start:
6,776,202 bp from pter
End:
6,797,101 bp from pter
Size:
20,900 bases
Orientation:
Plus strand

Genomic View for FBXO39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO39 Gene

Proteins for FBXO39 Gene

  • Protein details for FBXO39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4B4-FBX39_HUMAN
    Recommended name:
    F-box only protein 39
    Protein Accession:
    Q8N4B4
    Secondary Accessions:

    Protein attributes for FBXO39 Gene

    Size:
    442 amino acids
    Molecular mass:
    52646 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXO39 Gene

Proteomics data for FBXO39 Gene at MOPED

Post-translational modifications for FBXO39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO39 Gene

Domains for FBXO39 Gene

Gene Families for FBXO39 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO39 Gene

Suggested Antigen Peptide Sequences for FBXO39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4B4

UniProtKB/Swiss-Prot:

FBX39_HUMAN :
  • Q8N4B4
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO39: view

Function for FBXO39 Gene

Molecular function for FBXO39 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes for FBXO39 Gene

genes like me logo Genes that share phenotypes with FBXO39: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO39 Gene

Localization for FBXO39 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO39 Gene COMPARTMENTS Subcellular localization image for FBXO39 gene
Compartment Confidence
golgi apparatus 2
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO39 Gene

Pathways for FBXO39 Gene

SuperPathways for FBXO39 Gene

No Data Available

Interacting Proteins for FBXO39 Gene

Gene Ontology (GO) - Biological Process for FBXO39 Gene

None

No data available for Pathways by source for FBXO39 Gene

Transcripts for FBXO39 Gene

mRNA/cDNA for FBXO39 Gene

(7) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO39 Gene

F-box protein 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO39

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO39 Gene

No ASD Table

Relevant External Links for FBXO39 Gene

GeneLoc Exon Structure for
FBXO39
ECgene alternative splicing isoforms for
FBXO39

Expression for FBXO39 Gene

mRNA expression in normal human tissues for FBXO39 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO39 Gene

This gene is overexpressed in Testis (34.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FBXO39 Gene

SOURCE GeneReport for Unigene cluster for FBXO39 Gene Hs.368364

genes like me logo Genes that share expressions with FBXO39: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FBXO39 Gene

Orthologs for FBXO39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO39 35
  • 99.55 (n)
  • 99.32 (a)
FBXO39 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO39 35
  • 88.16 (n)
  • 86.88 (a)
FBXO39 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO39 35
  • 84.39 (n)
  • 85.52 (a)
FBXO39 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo39 35
  • 84.01 (n)
  • 83.94 (a)
Fbxo39 16
Fbxo39 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO39 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo39 35
  • 84.39 (n)
  • 85.97 (a)
chicken
(Gallus gallus)
Aves FBXO39 35
  • 68.65 (n)
  • 63.24 (a)
FBXO39 36
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for FBXO39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO39 Gene

ENSEMBL:
Gene Tree for FBXO39 (if available)
TreeFam:
Gene Tree for FBXO39 (if available)

Paralogs for FBXO39 Gene

No data available for Paralogs for FBXO39 Gene

Variants for FBXO39 Gene

Sequence variations from dbSNP and Humsavar for FBXO39 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs906749 -- 6,778,914(-) GGCAT(C/T)GTGGT intron-variant
rs906750 -- 6,778,427(-) TGTAC(A/T)TTTTT intron-variant
rs906751 -- 6,778,417(-) TTTCC(C/T)GTCCC intron-variant
rs906752 -- 6,778,389(-) GGGTG(C/T)AGGGG intron-variant
rs1509120 -- 6,790,364(-) GGTTA(A/C)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO39 Gene

Variant ID Type Subtype PubMed ID
nsv907630 CNV Gain 21882294
nsv907632 CNV Loss 21882294

Relevant External Links for FBXO39 Gene

HapMap Linkage Disequilibrium report
FBXO39
Human Gene Mutation Database (HGMD)
FBXO39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO39 Gene

Disorders for FBXO39 Gene

No disorders were found for FBXO39 Gene.

No data available for UniProtKB/Swiss-Prot for FBXO39 Gene

Publications for FBXO39 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  4. Identification of BCP-20 (FBXO39) as a cancer/testis antigen from colon cancer patients by SEREX. (PMID: 21338577) Song M.H. … Lee S.Y. (Biochem. Biophys. Res. Commun. 2011) 3
  5. Expression Analysis of Two Cancer-testis Genes, FBXO39 and TDRD4, in Breast Cancer Tissues and Cell Lines. (PMID: 24377578) Seifi-Alan M. … Najafi-Ashtiani M. (Asian Pac. J. Cancer Prev. 2013) 3

Products for FBXO39 Gene

Sources for FBXO39 Gene

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