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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO38 Gene

protein-coding   GIFtS: 46
GCID: GC05P147743

F-Box Protein 38

  Search for FBXO38
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 381 2     F-Box Only Protein 382
Modulator Of KLF7 Activity Homolog2 3     MoKA3
MOKA2 5     FBX385
Fbx382     

External Ids:    HGNC: 288441   Entrez Gene: 815452   Ensembl: ENSG000001458687   OMIM: 6085335   UniProtKB: Q6PIJ63   

Export aliases for FBXO38 gene to outside databases

Previous GC identifers: GC05P147795 GC05P142910


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FBXO38 Gene: 
FBXO38 (F-box protein 38) is a protein-coding gene.

UniProtKB/Swiss-Prot: FBX38_HUMAN, Q6PIJ6
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO38 gene promoter:
         GR   Spz1   AML1a   POU3F1   GR-beta   YY1   c-Ets-1   POU2F1a   GR-alpha   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO38 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q33.1

FBXO38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO38 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P147743:  view genomic region     (about GC identifiers)

Start:
147,763,498 bp from pter      End:
147,822,399 bp from pter
Size:
58,902 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX38_HUMAN, Q6PIJ6 (See protein sequence)
Recommended Name: F-box only protein 38  
Size: 1188 amino acids; 133944 Da
Subunit: Interacts with KLF7. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=AAG17983.1; Type=Frameshift; Positions=783; Sequence=AAH56147.1; Type=Erroneous
initiation; Sequence=AAK34945.1; Type=Erroneous initiation; Sequence=BAB14783.1; Type=Frameshift; Positions=349;
Secondary accessions: Q6PK72 Q7Z2U0 Q86VN3 Q9BXY6 Q9H837 Q9HC40
Alternative splicing: 3 isoforms:  Q6PIJ6-1   Q6PIJ6-2   Q6PIJ6-3   

Explore the universe of human proteins at neXtProt for FBXO38: NX_Q6PIJ6

Explore proteomics data for FBXO38 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PIJ6

  • FBXO38 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO38 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258652.1  NP_110420.3  

    ENSEMBL proteins: 
     ENSP00000342023   ENSP00000377895   ENSP00000426410   ENSP00000296701  

    Human Recombinant Protein Products for FBXO38: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO38 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    FBXO38 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q6PIJ6

    ProtoNet protein and cluster: Q6PIJ6

    UniProtKB/Swiss-Prot: FBX38_HUMAN, Q6PIJ6
    Domain: The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization (By similarity)
    Domain: The C-terminal region aa 473-1194 seems to be involved in nuclear localization (By similarity)
    Similarity: Contains 1 F-box domain


    FBXO38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX38_HUMAN, Q6PIJ6
    Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
    degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FBXO38 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXO38:
     Increased cell death HMECs cel  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO38 
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO38 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO38


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXO38

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for FBXO38 (Q6PIJ63 ENSP000003420234) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLF7O758403, ENSP000003095704I2D: score=3 STRING: ENSP00000309570
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    UBCENSP000003448184STRING: ENSP00000344818
    ABL2ENSP000003565954STRING: ENSP00000356595
    ENSG00000235107ENSP000003964394STRING: ENSP00000396439
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO38 (FBX38)

    Search CenterWatch for drugs/clinical trials and news about FBXO38 / FBX38

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO38 gene (3 alternative transcripts): 
    NM_205836.1  NM_001271723.1  NM_030793.4  

    Unigene Cluster for FBXO38:

    F-box protein 38
    Hs.483772  [show with all ESTs]
    Unigene Representative Sequence: NM_030793
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000340253(uc003lpf.1 uc003lpg.1 uc003lph.2) ENST00000503613
    ENST00000508326 ENST00000394370 ENST00000509411 ENST00000511080 ENST00000504971
    ENST00000521160 ENST00000509699 ENST00000513826 ENST00000502629 ENST00000502571
    ENST00000508670 ENST00000509273 ENST00000508485 ENST00000514832 ENST00000505399
    ENST00000504447
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO38:
    hsa-miR-142-5p hsa-miR-124 hsa-miR-3658 hsa-miR-506 hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidFBXO38 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO38
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO38

    Additional mRNA sequence: 

    AF177339.1 AF251055.1 AK024024.1 AK308414.1 AK313558.1 AL832841.1 BC005849.2 BC005873.2 
    BC015366.1 BC033454.1 BC047743.1 BC050424.1 BC056147.1 BC078159.1 

    12 DOTS entries:

    DT.99965267  DT.95271441  DT.100765693  DT.95347854  DT.95292072  DT.100008104  DT.100732122  DT.120880732 
    DT.40197481  DT.75167530  DT.95271439  DT.95271440 

    24/168 AceView cDNA sequences (see all 168):

    BM693713 BC050424 BU183814 AA280375 AA280143 AA280144 BF515440 BC015366 
    AI244385 BC005873 BM473353 BP357304 BQ959412 CR592588 AA825597 AI432973 
    BI858626 BX281627 BX358725 AL599600 BX105288 CB144648 NM_205836 AI912914 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO38 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^
    SP1:              -           -                                                                 -           -     -                 -                 -         
    SP2:                          -                                                                 -           -     -                 -                 -         
    SP3:                                                                                                                                -                 -         
    SP4:              -                                                                                                                                             
    SP5:                          -     -                                                                                                                           

    ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
    SP1:                          -                 -                 -                 -         
    SP2:              -     -     -                 -                 -                 -         
    SP3:                                            -                 -                 -         
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for FBXO38

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO38 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTTAAAA
    FBXO38 Expression
    About this image


    See FBXO38 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO38

    SOURCE GeneReport for Unigene cluster: Hs.483772
        SABiosciences Custom PCR Arrays for FBXO38
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO38 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo381 , 5 F-box protein 381, 5 89.37(n)1
    94.36(a)1
      18 (35.11 cM)5
    1070351  NM_134136.31  NP_598897.21 
     625040695 
    chicken
    (Gallus gallus)
    Aves LOC4266991 F-box only protein 38-like 77.47(n)
    81.9(a)
      426699  XM_003642051.1  XP_003642099.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO386
    Uncharacterized protein
    74(a)
    1 ↔ 1
    2(121727701-121755670)
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo381 F-box protein 38 67.63(n)
    74.35(a)
      799091  XM_001339450.3  XP_001339486.1 


    ENSEMBL Gene Tree for FBXO38 (if available)
    TreeFam Gene Tree for FBXO38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO38 gene

    FBXO38 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FBXO38
    PGOHUM00000245878


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1119 SNPs in FBXO38 are shown (see all 1119)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452470231,2
    --147761517(+) GAATTA/CATAGT 2 -- us2k10--------
    rs1491452821,2
    --147761618(+) CATAGA/CCATAT 2 -- us2k10--------
    rs1165660361,2
    C,F--147761741(+) AGGAAG/AAACAC 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs77182101,2
    C,F,H--147761948(+) CTGTAA/CCATCA 2 -- us2k16Minor allele frequency- C:0.02NS EA NA 538
    rs760255011,2
    C,F--147761952(+) AACATC/TAAGGT 2 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1829986881,2
    --147762233(+) TCAGGC/GCAATT 2 -- us2k10--------
    rs38120131,2
    H--147762287(-) CTAGTG/TCAGGG 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1867207861,2
    --147762294(+) CTAGAA/CACTTT 2 -- us2k10--------
    rs1922988631,2
    --147762363(+) TCCTTG/TATTAA 2 -- us2k10--------
    rs1449693001,2
    --147762452(+) ATGAAA/GGCTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO38 (147763498 - 147822399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FBXO38:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830516CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXO38 for disorders           About MalaCards
    OMIM gene information: 608533    OMIM disorders: --


    FBXO38 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO38
    Human Genome Epidemiology (HuGE) Navigator: FBXO38 (1 document)

    Export disorders for FBXO38 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO38 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with FBXO38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. Genome-wide association study of periodontal pathogen colonization. (PubMed id 22699663)1 Divaris K....Offenbacher S. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81545 HGNC: 28844 AceView: FBXO38 Ensembl:ENSG00000145868 euGenes: HUgn81545
    ECgene: FBXO38 H-InvDB: FBXO38

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO38 gene:
    Search GeneIP for patents involving FBXO38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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