Aliases for FBXO36 Gene
External Ids for FBXO36 Gene
- HGNC: 27020
- Entrez Gene: 130888
- Ensembl: ENSG00000153832
- OMIM: 609105
- UniProtKB: Q8NEA4
Previous GeneCards Identifiers for FBXO36 Gene
- GC02P230989
- GC02P230612
- GC02P230495
- GC02P230787
- GC02P222626
Summaries for FBXO36 Gene
-
Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO36 Gene
FBXO36 (F-Box Protein 36) is a Protein Coding gene.
UniProtKB/Swiss-Prot for FBXO36 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO36 Gene
Genomics for FBXO36 Gene
Regulatory Elements for FBXO36 Gene
Enhancers for FBXO36 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G230755 | 1.2 | Ensembl ENCODE | 13.1 | +835.4 | 835352 | 4.7 | PKNOX1 FOXA2 ZNF493 ZFP64 YBX1 BMI1 ZNF155 ZNF138 FOS RELB | FBXO36 SLC16A14 CAB39 TEX44 TRIP12 RNU6-451P RNU6-268P GC02P230779 |
| GH02G229919 | 1.6 | Ensembl ENCODE dbSUPER | 9.3 | -0.8 | -771 | 4.7 | HNRNPUL1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 | FBXO36 TRIP12 RNU6-613P |
| GH02G229958 | 0.5 | FANTOM5 | 12.9 | +36.7 | 36740 | 0.1 | ESRRA | FBXO36 RNU6-964P TRIP12 LOC105373924 RNU6-1027P |
| GH02G230222 | 1.4 | Ensembl ENCODE dbSUPER | 4.3 | +303.3 | 303316 | 6.1 | HDGF TBP PKNOX1 TBL1XR1 SIN3A ZBTB40 RFX5 SCRT2 RCOR1 FOS | RNU6-451P SP140 ENSG00000225963 FBXO36 SP110 |
| GH02G229780 | 0.7 | ENCODE | 8 | -141.0 | -141002 | 1.5 | HDGF CTCF MAX CHD7 RAD21 ZFHX2 GATA2 EGR1 SMC3 ZNF143 | FBXO36 TRIP12 PIR44053 DNER |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO36 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO36 gene promoter:
Regulatory Element Products
Genomic Location for FBXO36 Gene
- Chromosome:
- 2
- Start:
- 229,922,302 bp from pter
- End:
- 230,013,109 bp from pter
- Size:
- 90,808 bases
- Orientation:
- Plus strand
Genomic View for FBXO36 Gene
Genes around FBXO36 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.3 by Ensembl
- 2q36.3 by Entrez Gene
- 2q36.3 by HGNC
FBXO36 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO36 Gene
Proteins for FBXO36 Gene
-
Protein details for FBXO36 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEA4-FBX36_HUMAN
- Recommended name:
- F-box only protein 36
- Protein Accession:
- Q8NEA4
- B3KVQ6
- Q53TE6
- Q8WWD4
Protein attributes for FBXO36 Gene
- Size:
- 188 amino acids
- Molecular mass:
- 22105 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
Protein Expression for FBXO36 Gene
Post-translational modifications for FBXO36 Gene
Other Protein References for FBXO36 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- antibodies-online Antibodies for FBXO36: See all 28
- GeneTex FBXO36 antibody for FBXO36
Protein Products
-
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- antibodies-online Proteins for FBXO36: See all 7
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- Search GeneTex for Proteins for FBXO36
Assay Products
- antibodies-online Kits for FBXO36: See all 15
No data available for DME Specific Peptides for FBXO36 Gene
Domains & Families for FBXO36 Gene
Gene Families for FBXO36 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FBXO36 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO36 Gene
Function for FBXO36 Gene
Molecular function for FBXO36 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Phenotypes for FBXO36 Gene
- MGI mutant phenotypes for FBXO36:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXO36:
Animal Models for FBXO36 Gene
- MGI Knock Outs for FBXO36:
-
- Fbxo36 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO36 gene
-
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- Search ViGene Biosciences for FBXO36
CRISPR Products
-
OriGene CRISPR knockouts for FBXO36
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO36
- GenScript: Design CRISPR guide RNA sequences for FBXO36
miRNA for FBXO36 Gene
- miRTarBase miRNAs that target FBXO36
-
- hsa-mir-215-5p (MIRT024677)
- hsa-mir-192-5p (MIRT026437)
- hsa-mir-6079 (MIRT671634)
- hsa-mir-6514-3p (MIRT671635)
- hsa-mir-7977 (MIRT671636)
- hsa-mir-24-3p (MIRT671637)
- hsa-mir-4284 (MIRT671638)
- hsa-mir-671-5p (MIRT671639)
- hsa-mir-6828-5p (MIRT671640)
- hsa-mir-6847-3p (MIRT671641)
- hsa-mir-6811-3p (MIRT671642)
- hsa-mir-214-5p (MIRT671643)
- hsa-mir-4786-3p (MIRT671644)
- hsa-mir-383-3p (MIRT671645)
- hsa-mir-3677-5p (MIRT671646)
miRNA Products
- Search ViGene Biosciences for FBXO36
Inhibitory RNA Products
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-
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Cell Line Products
-
Horizon Cell Lines for FBXO36
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO36 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO36 Gene
Localization for FBXO36 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO36 Gene
Pathways & Interactions for FBXO36 Gene
No Data Available
Interacting Proteins for FBXO36 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| SKP1 |
No data available for Pathways by source and SIGNOR curated interactions for FBXO36 Gene
Transcripts for FBXO36 Gene
mRNA/cDNA for FBXO36 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (39) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO36
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO36
- GenScript: Design CRISPR guide RNA sequences for FBXO36
miRNA Products
- Search ViGene Biosciences for FBXO36
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXO36
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO36 gene
Clone Products
-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | - | ||||||||||||||
| SP3: |
Expression for FBXO36 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO36 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXO36 Gene:
FBXO36SOURCE GeneReport for Unigene cluster for FBXO36 Gene:
Hs.140666Primer Products
-
OriGene qPCR primer pairs for FBXO36
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO36 Gene
Orthologs for FBXO36 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO36 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO36 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO36 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fbxo36 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo36 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO36 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FBXO36 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo36 34 |
|
||
| Str.16790 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo36a 34 35 |
|
||
| fbxo36b 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXO36 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO36 Gene
Pseudogenes.org Pseudogenes for FBXO36 Gene
No data available for Paralogs for FBXO36 Gene
Variants for FBXO36 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003438 | -- | 229,962,896(+) | GGTCT(C/G)AAACT | intron-variant | |
| rs1000017238 | -- | 229,922,449(+) | TTTGG(C/T)CCCTT | intron-variant, upstream-variant-2KB | |
| rs1000018466 | -- | 229,930,884(+) | ACTGC(A/T)CCTCC | intron-variant | |
| rs1000053425 | -- | 229,971,179(+) | TAAAA(C/G)CCCGT | intron-variant | |
| rs1000082030 | -- | 230,007,270(+) | CAGGC(C/T)GGGAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv164e55 | CNV | gain | 17911159 |
| dgv4179n100 | CNV | gain | 25217958 |
| dgv7330n54 | CNV | gain | 21841781 |
| dgv7331n54 | CNV | loss | 21841781 |
| dgv7332n54 | CNV | loss | 21841781 |
| dgv7333n54 | CNV | loss | 21841781 |
| esv21790 | CNV | loss | 19812545 |
| esv2660647 | CNV | deletion | 23128226 |
| esv2675475 | CNV | deletion | 23128226 |
| esv2721590 | CNV | deletion | 23290073 |
| esv2751841 | CNV | gain | 17911159 |
| esv32933 | CNV | loss | 17666407 |
| esv3561128 | CNV | deletion | 23714750 |
| esv3575337 | CNV | gain | 25503493 |
| esv3584368 | CNV | loss | 25503493 |
| esv3594584 | CNV | loss | 21293372 |
| esv3594585 | CNV | gain | 21293372 |
| esv3594586 | CNV | loss | 21293372 |
| esv3594587 | CNV | loss | 21293372 |
| esv3594588 | CNV | loss | 21293372 |
| esv3594589 | CNV | gain | 21293372 |
| esv3594590 | CNV | loss | 21293372 |
| esv3594591 | CNV | loss | 21293372 |
| esv3594592 | CNV | gain | 21293372 |
| esv3594593 | CNV | loss | 21293372 |
| esv987544 | CNV | deletion | 20482838 |
| nsv1008431 | CNV | gain | 25217958 |
| nsv1138899 | CNV | deletion | 24896259 |
| nsv3201 | CNV | deletion | 18451855 |
| nsv460118 | CNV | gain | 19166990 |
| nsv584650 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.93;
83.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO36 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO36
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO36 Gene
Disorders for FBXO36 Gene
Relevant External Links for FBXO36
No disorders were found for FBXO36 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO36 Gene
Publications for FBXO36 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. (PMID: 26087183) Tian X. … Jiang Y. (Oncotarget 2015) 3 64
Products for FBXO36 Gene
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- antibodies-online Antibodies for FBXO36: See all 28
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO36 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer