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Aliases for FBXO36 Gene

Aliases for FBXO36 Gene

  • F-Box Protein 36 2 3
  • Fbx36 3 4 6
  • F-Box Only Protein 36 2 3

External Ids for FBXO36 Gene

Summaries for FBXO36 Gene

Entrez Gene Summary for FBXO36 Gene

  • Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO36 Gene

FBXO36 (F-Box Protein 36) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO36 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO36 Gene

Genomics for FBXO36 Gene

Genomic Location for FBXO36 Gene

Start:
229,922,302 bp from pter
End:
230,013,109 bp from pter
Size:
90,808 bases
Orientation:
Plus strand

Genomic View for FBXO36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO36 Gene

Regulatory Elements for FBXO36 Gene

Proteins for FBXO36 Gene

  • Protein details for FBXO36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEA4-FBX36_HUMAN
    Recommended name:
    F-box only protein 36
    Protein Accession:
    Q8NEA4
    Secondary Accessions:
    • B3KVQ6
    • Q53TE6
    • Q8WWD4

    Protein attributes for FBXO36 Gene

    Size:
    188 amino acids
    Molecular mass:
    22105 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO36 Gene

Proteomics data for FBXO36 Gene at MOPED

Post-translational modifications for FBXO36 Gene

No Post-translational modifications

Other Protein References for FBXO36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO36 Gene

Domains for FBXO36 Gene

Gene Families for FBXO36 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO36 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FBX36_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q8NEA4
genes like me logo Genes that share domains with FBXO36: view

Function for FBXO36 Gene

Molecular function for FBXO36 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXO36: view

Phenotypes for FBXO36 Gene

genes like me logo Genes that share phenotypes with FBXO36: view

miRNA for FBXO36 Gene

miRTarBase miRNAs that target FBXO36

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO36 Gene

Localization for FBXO36 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO36 Gene COMPARTMENTS Subcellular localization image for FBXO36 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FBXO36 Gene

Pathways for FBXO36 Gene

SuperPathways for FBXO36 Gene

No Data Available

Interacting Proteins for FBXO36 Gene

Gene Ontology (GO) - Biological Process for FBXO36 Gene

None

No data available for Pathways by source for FBXO36 Gene

Transcripts for FBXO36 Gene

Unigene Clusters for FBXO36 Gene

F-box protein 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -
SP3:

Relevant External Links for FBXO36 Gene

GeneLoc Exon Structure for
FBXO36
ECgene alternative splicing isoforms for
FBXO36

Expression for FBXO36 Gene

mRNA expression in normal human tissues for FBXO36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FBXO36 Gene

SOURCE GeneReport for Unigene cluster for FBXO36 Gene Hs.140666

genes like me logo Genes that share expressions with FBXO36: view

Orthologs for FBXO36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO36 36
  • 99.29 (n)
  • 99.47 (a)
FBXO36 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO36 36
  • 86.63 (n)
  • 83.96 (a)
FBXO36 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO36 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo36 36
  • 82.08 (n)
  • 76.88 (a)
Fbxo36 16
Fbxo36 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO36 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo36 36
  • 82.23 (n)
  • 80.22 (a)
lizard
(Anolis carolinensis)
Reptilia FBXO36 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo36 36
  • 64.46 (n)
  • 61.33 (a)
Str.16790 36
zebrafish
(Danio rerio)
Actinopterygii fbxo36a 36
  • 58.9 (n)
  • 55.83 (a)
fbxo36a 37
  • 50 (a)
OneToMany
fbxo36b 37
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for FBXO36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO36 Gene

ENSEMBL:
Gene Tree for FBXO36 (if available)
TreeFam:
Gene Tree for FBXO36 (if available)

Paralogs for FBXO36 Gene

Pseudogenes.org Pseudogenes for FBXO36 Gene

genes like me logo Genes that share paralogs with FBXO36: view

No data available for Paralogs for FBXO36 Gene

Variants for FBXO36 Gene

Sequence variations from dbSNP and Humsavar for FBXO36 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs481567 -- 229,940,295(-) GTTAC(C/T)AACCA intron-variant
rs499449 -- 229,976,358(+) AGGAA(C/T)GGAAC intron-variant
rs500016 -- 229,957,222(-) TGTGG(C/T)TTCCT intron-variant
rs504553 -- 229,940,115(-) TGCCA(A/G)TGGCT intron-variant
rs505425 -- 229,931,920(+) TATAt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO36 Gene

Variant ID Type Subtype PubMed ID
esv2751841 CNV Gain 17911159
dgv164e55 CNV Gain 17911159
nsv460118 CNV Gain 19166990
esv987544 CNV Deletion 20482838
nsv875941 CNV Loss 21882294
esv2660647 CNV Deletion 23128226
nsv3201 CNV Loss 18451855
esv21790 CNV Loss 19812545
esv2675475 CNV Deletion 23128226
esv2721590 CNV Deletion 23290073
esv32933 CNV Loss 17666407

Relevant External Links for FBXO36 Gene

HapMap Linkage Disequilibrium report
FBXO36

Disorders for FBXO36 Gene

Relevant External Links for FBXO36

Genetic Association Database (GAD)
FBXO36
Human Genome Epidemiology (HuGE) Navigator
FBXO36
genes like me logo Genes that share disorders with FBXO36: view

No data available for UniProtKB/Swiss-Prot for FBXO36 Gene

Publications for FBXO36 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for FBXO36 Gene

Sources for FBXO36 Gene

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