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Aliases for FBXO36 Gene

Aliases for FBXO36 Gene

  • F-Box Protein 36 2 3 5
  • Fbx36 3 4
  • F-Box Only Protein 36 2

External Ids for FBXO36 Gene

Previous GeneCards Identifiers for FBXO36 Gene

  • GC02P230989
  • GC02P230612
  • GC02P230495
  • GC02P230787
  • GC02P222626

Summaries for FBXO36 Gene

Entrez Gene Summary for FBXO36 Gene

  • Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO36 Gene

FBXO36 (F-Box Protein 36) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO36 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO36 Gene

Genomics for FBXO36 Gene

Regulatory Elements for FBXO36 Gene

Enhancers for FBXO36 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO36 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO36 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO36 Gene

229,922,302 bp from pter
230,013,109 bp from pter
90,808 bases
Plus strand

Genomic View for FBXO36 Gene

Genes around FBXO36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO36 Gene

Proteins for FBXO36 Gene

  • Protein details for FBXO36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 36
    Protein Accession:
    Secondary Accessions:
    • B3KVQ6
    • Q53TE6
    • Q8WWD4

    Protein attributes for FBXO36 Gene

    188 amino acids
    Molecular mass:
    22105 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO36 Gene


neXtProt entry for FBXO36 Gene

Proteomics data for FBXO36 Gene at MOPED

Post-translational modifications for FBXO36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO36 Gene

Domains & Families for FBXO36 Gene

Gene Families for FBXO36 Gene

Protein Domains for FBXO36 Gene


Suggested Antigen Peptide Sequences for FBXO36 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO36: view

Function for FBXO36 Gene

Molecular function for FBXO36 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXO36: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO36 Gene

Localization for FBXO36 Gene

Subcellular locations from

Jensen Localization Image for FBXO36 Gene COMPARTMENTS Subcellular localization image for FBXO36 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO36 Gene

Pathways & Interactions for FBXO36 Gene

SuperPathways for FBXO36 Gene

No Data Available

Interacting Proteins for FBXO36 Gene

Gene Ontology (GO) - Biological Process for FBXO36 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO36 Gene

Drugs & Compounds for FBXO36 Gene

No Compound Related Data Available

Transcripts for FBXO36 Gene

Unigene Clusters for FBXO36 Gene

F-box protein 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2: - - -

Relevant External Links for FBXO36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO36 Gene

mRNA expression in normal human tissues for FBXO36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO36 Gene

SOURCE GeneReport for Unigene cluster for FBXO36 Gene Hs.140666

genes like me logo Genes that share expression patterns with FBXO36: view

Protein tissue co-expression partners for FBXO36 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO36 Gene

Orthologs for FBXO36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO36 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO36 35
  • 86.63 (n)
  • 83.96 (a)
FBXO36 36
  • 84 (a)
(Mus musculus)
Mammalia Fbxo36 35
  • 82.08 (n)
  • 76.88 (a)
Fbxo36 16
Fbxo36 36
  • 76 (a)
(Pan troglodytes)
Mammalia FBXO36 35
  • 99.29 (n)
  • 99.47 (a)
FBXO36 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxo36 35
  • 82.23 (n)
  • 80.22 (a)
(Canis familiaris)
Mammalia FBXO36 36
  • 84 (a)
(Monodelphis domestica)
Mammalia FBXO36 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FBXO36 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo36 35
  • 64.46 (n)
  • 61.33 (a)
Str.16790 35
(Danio rerio)
Actinopterygii fbxo36a 35
  • 58.9 (n)
  • 55.83 (a)
fbxo36a 36
  • 50 (a)
fbxo36b 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for FBXO36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO36 Gene

Gene Tree for FBXO36 (if available)
Gene Tree for FBXO36 (if available)

Paralogs for FBXO36 Gene Pseudogenes for FBXO36 Gene

genes like me logo Genes that share paralogs with FBXO36: view

No data available for Paralogs for FBXO36 Gene

Variants for FBXO36 Gene

Sequence variations from dbSNP and Humsavar for FBXO36 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1035834 - 229,996,803(+) AATTT(G/T)TGCAA reference, missense
rs481567 -- 229,940,295(-) GTTAC(C/T)AACCA intron-variant
rs499449 -- 229,976,358(+) AGGAA(C/T)GGAAC intron-variant
rs504553 -- 229,940,115(-) TGCCA(A/G)TGGCT intron-variant
rs505425 -- 229,931,920(+) TATAt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO36 Gene

Variant ID Type Subtype PubMed ID
esv2751841 CNV Gain 17911159
dgv164e55 CNV Gain 17911159
nsv460118 CNV Gain 19166990
esv987544 CNV Deletion 20482838
nsv875941 CNV Loss 21882294
esv2660647 CNV Deletion 23128226
nsv3201 CNV Loss 18451855
esv21790 CNV Loss 19812545
esv2675475 CNV Deletion 23128226
esv2721590 CNV Deletion 23290073
esv32933 CNV Loss 17666407

Variation tolerance for FBXO36 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.93; 83.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO36 Gene

Disorders for FBXO36 Gene

Relevant External Links for FBXO36

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO36 Gene

Publications for FBXO36 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FBXO36 Gene

Sources for FBXO36 Gene