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Aliases for FBXO34 Gene

Aliases for FBXO34 Gene

  • F-Box Protein 34 2 3 5
  • F-Box Only Protein 34 2 3
  • Fbx34 3 4
  • Protein CGI-301 3
  • CGI-301 3

External Ids for FBXO34 Gene

Previous GeneCards Identifiers for FBXO34 Gene

  • GC14P049534
  • GC14P053728
  • GC14P054807
  • GC14P055738
  • GC14P035900

Summaries for FBXO34 Gene

Entrez Gene Summary for FBXO34 Gene

  • Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO34 Gene

FBXO34 (F-Box Protein 34) is a Protein Coding gene. An important paralog of this gene is FBXO46.

UniProtKB/Swiss-Prot for FBXO34 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO34 Gene

Genomics for FBXO34 Gene

Regulatory Elements for FBXO34 Gene

Enhancers for FBXO34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G055113 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -147.3 -147320 21.7 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 LOC105370509 LGALS3 ATG14 WDHD1 GCH1 FBXO34 DLGAP5 SOCS4 ENSG00000259318 MAPK1IP1L
GH14G055301 1.4 FANTOM5 Ensembl ENCODE 12.7 +32.0 31998 4.2 ZNF146 CBX3 CEBPG FOSL1 FOSL2 ZNF600 PRDM10 NFE2 FOS SMARCE1 LOC105370509 FBXO34 ENSG00000259318 GCH1 LGALS3 MAPK1IP1L CHMP4BP1 ENSG00000258455
GH14G055097 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -167.9 -167899 12.7 MLX DMAP1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D GLIS1 NBN LGALS3 LOC105370509 MAPK1IP1L GCH1 DLGAP5 FBXO34 ENSG00000259318 ATG14 GC14M055058 GC14M055059
GH14G055297 0.9 Ensembl ENCODE 12 +27.0 26997 1.0 CTCF JUN CHD1 JUNB RAD21 SREBF1 NFIC FOXK2 KLF9 PRDM10 LOC105370509 FBXO34 DLGAP5 ENSG00000259318 CHMP4BP1 ENSG00000278818
GH14G055070 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -196.4 -196408 8.6 HDGF PKNOX1 WRNIP1 BRCA1 ZNF121 GATA2 ZNF143 FOS JUNB TBX21 LGALS3 LOC105370509 MAPK1IP1L FBXO34 ATG14 GC14M055058 GC14M055059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO34 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068814 697 2001 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 ZBTB7B YY1

Genomic Location for FBXO34 Gene

Chromosome:
14
Start:
55,271,303 bp from pter
End:
55,361,918 bp from pter
Size:
90,616 bases
Orientation:
Plus strand

Genomic View for FBXO34 Gene

Genes around FBXO34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO34 Gene

Proteins for FBXO34 Gene

  • Protein details for FBXO34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWN3-FBX34_HUMAN
    Recommended name:
    F-box only protein 34
    Protein Accession:
    Q9NWN3
    Secondary Accessions:
    • Q2VPB5
    • Q4VBP5
    • Q86TY4

    Protein attributes for FBXO34 Gene

    Size:
    711 amino acids
    Molecular mass:
    78711 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=BAA91346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO34 Gene

Post-translational modifications for FBXO34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO34 Gene

Domains & Families for FBXO34 Gene

Gene Families for FBXO34 Gene

Protein Domains for FBXO34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO34: view

No data available for UniProtKB/Swiss-Prot for FBXO34 Gene

Function for FBXO34 Gene

Molecular function for FBXO34 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FBXO34: view
genes like me logo Genes that share phenotypes with FBXO34: view

Animal Model Products

CRISPR Products

miRNA for FBXO34 Gene

miRTarBase miRNAs that target FBXO34

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO34 Gene

Localization for FBXO34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO34 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO34 Gene

Pathways & Interactions for FBXO34 Gene

SuperPathways for FBXO34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO34 Gene

Drugs & Compounds for FBXO34 Gene

No Compound Related Data Available

Transcripts for FBXO34 Gene

Unigene Clusters for FBXO34 Gene

F-box protein 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO34 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - -

Relevant External Links for FBXO34 Gene

GeneLoc Exon Structure for
FBXO34
ECgene alternative splicing isoforms for
FBXO34

Expression for FBXO34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO34 Gene

Protein differential expression in normal tissues from HIPED for FBXO34 Gene

This gene is overexpressed in Islet of Langerhans (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO34 Gene



Protein tissue co-expression partners for FBXO34 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO34 Gene:

FBXO34

SOURCE GeneReport for Unigene cluster for FBXO34 Gene:

Hs.525348

Evidence on tissue expression from TISSUES for FBXO34 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with FBXO34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO34 Gene

Orthologs for FBXO34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO34 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia FBXO34 34 35
  • 87.92 (n)
cow
(Bos Taurus)
Mammalia FBXO34 35 34
  • 87.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo34 34
  • 79.3 (n)
mouse
(Mus musculus)
Mammalia Fbxo34 34 16 35
  • 78.56 (n)
chicken
(Gallus gallus)
Aves FBXO34 34 35
  • 65.89 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO34 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo34 34
  • 60.32 (n)
Str.14993 34
zebrafish
(Danio rerio)
Actinopterygii si:ch73-132g21.5 34
  • 50.29 (n)
FBXO34 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10603 35
  • 15 (a)
OneToMany
Species where no ortholog for FBXO34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO34 Gene

ENSEMBL:
Gene Tree for FBXO34 (if available)
TreeFam:
Gene Tree for FBXO34 (if available)

Paralogs for FBXO34 Gene

Paralogs for FBXO34 Gene

genes like me logo Genes that share paralogs with FBXO34: view

Variants for FBXO34 Gene

Sequence variations from dbSNP and Humsavar for FBXO34 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000028849 -- 55,280,247(+) GAGAT(A/G)ACTAT intron-variant
rs1000078009 -- 55,324,354(+) GAAGG(A/G)TTGTC intron-variant
rs1000125222 -- 55,285,874(+) CTGTT(A/G)AAAGT intron-variant
rs1000139506 -- 55,324,612(+) GATAG(A/G)TTTTT intron-variant
rs1000150287 -- 55,270,779(+) GGGAA(A/T)CAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXO34 Gene

Variant ID Type Subtype PubMed ID
esv1218411 CNV insertion 17803354
esv2657596 CNV deletion 23128226
esv2657865 CNV deletion 23128226
esv2748726 CNV deletion 23290073
esv3551587 CNV deletion 23714750
esv3551588 CNV deletion 23714750
esv3634576 CNV loss 21293372
nsv512361 CNV loss 21212237
nsv84773 CNV deletion 16902084

Variation tolerance for FBXO34 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO34 Gene

Disorders for FBXO34 Gene

Relevant External Links for FBXO34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO34

No disorders were found for FBXO34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO34 Gene

Publications for FBXO34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. (PMID: 26087183) Tian X. … Jiang Y. (Oncotarget 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for FBXO34 Gene

Sources for FBXO34 Gene

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