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Aliases for FBXO34 Gene

Aliases for FBXO34 Gene

  • F-Box Protein 34 2 3 5
  • Fbx34 3 4
  • F-Box Only Protein 34 2
  • Protein CGI-301 3
  • CGI-301 3

External Ids for FBXO34 Gene

Previous GeneCards Identifiers for FBXO34 Gene

  • GC14P049534
  • GC14P053728
  • GC14P054807
  • GC14P055738
  • GC14P035900

Summaries for FBXO34 Gene

Entrez Gene Summary for FBXO34 Gene

  • Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO34 Gene

FBXO34 (F-Box Protein 34) is a Protein Coding gene. An important paralog of this gene is FBXO46.

UniProtKB/Swiss-Prot for FBXO34 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO34 Gene

Genomics for FBXO34 Gene

Regulatory Elements for FBXO34 Gene

Enhancers for FBXO34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO34 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO34 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO34 Gene

55,271,303 bp from pter
55,361,918 bp from pter
90,616 bases
Plus strand

Genomic View for FBXO34 Gene

Genes around FBXO34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO34 Gene

Proteins for FBXO34 Gene

  • Protein details for FBXO34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 34
    Protein Accession:
    Secondary Accessions:
    • Q2VPB5
    • Q4VBP5
    • Q86TY4

    Protein attributes for FBXO34 Gene

    711 amino acids
    Molecular mass:
    78711 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=BAA91346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO34 Gene

Proteomics data for FBXO34 Gene at MOPED

Post-translational modifications for FBXO34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO34 Gene

No data available for DME Specific Peptides for FBXO34 Gene

Domains & Families for FBXO34 Gene

Gene Families for FBXO34 Gene

Protein Domains for FBXO34 Gene


Suggested Antigen Peptide Sequences for FBXO34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO34: view

Function for FBXO34 Gene

Molecular function for FBXO34 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXO34: view

Animal Model Products

miRNA for FBXO34 Gene

miRTarBase miRNAs that target FBXO34

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO34 Gene

Localization for FBXO34 Gene

Subcellular locations from

Jensen Localization Image for FBXO34 Gene COMPARTMENTS Subcellular localization image for FBXO34 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for FBXO34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FBXO34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO34 Gene

Pathways & Interactions for FBXO34 Gene

SuperPathways for FBXO34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO34 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO34 Gene

Drugs & Compounds for FBXO34 Gene

No Compound Related Data Available

Transcripts for FBXO34 Gene

mRNA/cDNA for FBXO34 Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO34 Gene

F-box protein 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO34 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - -

Relevant External Links for FBXO34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO34 Gene

mRNA expression in normal human tissues for FBXO34 Gene

Protein differential expression in normal tissues from HIPED for FBXO34 Gene

This gene is overexpressed in Islet of Langerhans (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO34 Gene

SOURCE GeneReport for Unigene cluster for FBXO34 Gene Hs.525348

genes like me logo Genes that share expression patterns with FBXO34: view

Protein tissue co-expression partners for FBXO34 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO34 Gene

Orthologs for FBXO34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO34 35
  • 87.62 (n)
  • 84.95 (a)
FBXO34 36
  • 84 (a)
(Canis familiaris)
Mammalia FBXO34 35
  • 87.92 (n)
  • 85.75 (a)
FBXO34 36
  • 79 (a)
(Mus musculus)
Mammalia Fbxo34 35
  • 78.56 (n)
  • 73.53 (a)
Fbxo34 16
Fbxo34 36
  • 68 (a)
(Pan troglodytes)
Mammalia FBXO34 35
  • 99.58 (n)
  • 99.3 (a)
FBXO34 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxo34 35
  • 79.3 (n)
  • 74.16 (a)
(Gallus gallus)
Aves FBXO34 35
  • 65.89 (n)
  • 62.59 (a)
FBXO34 36
  • 56 (a)
(Anolis carolinensis)
Reptilia FBXO34 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo34 35
  • 60.32 (n)
  • 52.59 (a)
Str.14993 35
(Danio rerio)
Actinopterygii si:ch73-132g21.5 35
  • 50.29 (n)
  • 43.58 (a)
FBXO34 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10603 36
  • 15 (a)
Species with no ortholog for FBXO34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO34 Gene

Gene Tree for FBXO34 (if available)
Gene Tree for FBXO34 (if available)

Paralogs for FBXO34 Gene

Paralogs for FBXO34 Gene

genes like me logo Genes that share paralogs with FBXO34: view

Variants for FBXO34 Gene

Sequence variations from dbSNP and Humsavar for FBXO34 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1045002 - 55,351,799(+) TTCCA(A/G/T)TTTAA reference, missense
rs3742569 - 55,351,988(+) TGTAC(C/T)GCCAG reference, missense
rs35070799 - 55,351,685(+) TGCTG(C/T)TGATT reference, missense
rs10138395 - 55,352,501(+) AAAAG(G/T)GACTG reference, missense
rs7140628 -- 55,293,963(+) TACGC(A/C)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO34 Gene

Variant ID Type Subtype PubMed ID
nsv512361 CNV Loss 21212237
esv2748726 CNV Deletion 23290073
esv2657596 CNV Deletion 23128226
esv271549 CNV Insertion 20981092
esv272758 CNV Insertion 20981092
esv1218411 CNV Insertion 17803354
nsv84773 CNV Loss 16902084
esv2657865 CNV Deletion 23128226
nsv901957 CNV Gain 21882294

Variation tolerance for FBXO34 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.23; 70.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO34 Gene

Disorders for FBXO34 Gene

Relevant External Links for FBXO34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO34 Gene

Publications for FBXO34 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for FBXO34 Gene

Sources for FBXO34 Gene