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Aliases for FBXO34 Gene

Aliases for FBXO34 Gene

  • F-Box Protein 34 2 3
  • Fbx34 3 4 6
  • F-Box Only Protein 34 2 3
  • Protein CGI-301 3
  • CGI-301 3

External Ids for FBXO34 Gene

Previous GeneCards Identifiers for FBXO34 Gene

  • GC14P049534
  • GC14P053728
  • GC14P054807
  • GC14P055738
  • GC14P035900

Summaries for FBXO34 Gene

Entrez Gene Summary for FBXO34 Gene

  • Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO34 Gene

FBXO34 (F-Box Protein 34) is a Protein Coding gene. An important paralog of this gene is FBXO46.

UniProtKB/Swiss-Prot for FBXO34 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO34 Gene

Genomics for FBXO34 Gene

Regulatory Elements for FBXO34 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO34 Gene

55,271,303 bp from pter
55,361,918 bp from pter
90,616 bases
Plus strand

Genomic View for FBXO34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO34 Gene

Proteins for FBXO34 Gene

  • Protein details for FBXO34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 34
    Protein Accession:
    Secondary Accessions:
    • Q2VPB5
    • Q4VBP5
    • Q86TY4

    Protein attributes for FBXO34 Gene

    711 amino acids
    Molecular mass:
    78711 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=BAA91346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62596.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO34 Gene

Proteomics data for FBXO34 Gene at MOPED

Post-translational modifications for FBXO34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO34 Gene

Antibody Products

No data available for DME Specific Peptides for FBXO34 Gene

Domains for FBXO34 Gene

Gene Families for FBXO34 Gene

Protein Domains for FBXO34 Gene


Suggested Antigen Peptide Sequences for FBXO34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO34: view

Function for FBXO34 Gene

Molecular function for FBXO34 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FBXO34: view

Phenotypes for FBXO34 Gene

GenomeRNAi human phenotypes for FBXO34:
genes like me logo Genes that share phenotypes with FBXO34: view

Animal Model Products

miRNA for FBXO34 Gene

miRTarBase miRNAs that target FBXO34

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO34

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO34 Gene

Localization for FBXO34 Gene

Subcellular locations from

Jensen Localization Image for FBXO34 Gene COMPARTMENTS Subcellular localization image for FBXO34 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBXO34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FBXO34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO34 Gene

Pathways for FBXO34 Gene

SuperPathways for FBXO34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO34 Gene


No data available for Pathways by source for FBXO34 Gene

Transcripts for FBXO34 Gene

mRNA/cDNA for FBXO34 Gene

(4) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO34 Gene

F-box protein 34:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO34

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO34 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - -

Relevant External Links for FBXO34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO34 Gene

mRNA expression in normal human tissues for FBXO34 Gene

Protein differential expression in normal tissues for FBXO34 Gene

This gene is overexpressed in Islet of Langerhans (68.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO34 Gene

SOURCE GeneReport for Unigene cluster for FBXO34 Gene Hs.525348

genes like me logo Genes that share expressions with FBXO34: view

Expression partners for FBXO34 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO34 Gene

Orthologs for FBXO34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO34 35
  • 87.62 (n)
  • 84.95 (a)
FBXO34 36
  • 84 (a)
(Canis familiaris)
Mammalia FBXO34 35
  • 87.92 (n)
  • 85.75 (a)
FBXO34 36
  • 79 (a)
(Mus musculus)
Mammalia Fbxo34 35
  • 78.56 (n)
  • 73.53 (a)
Fbxo34 16
Fbxo34 36
  • 68 (a)
(Pan troglodytes)
Mammalia FBXO34 35
  • 99.58 (n)
  • 99.3 (a)
FBXO34 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxo34 35
  • 79.3 (n)
  • 74.16 (a)
(Gallus gallus)
Aves FBXO34 35
  • 65.89 (n)
  • 62.59 (a)
FBXO34 36
  • 56 (a)
(Anolis carolinensis)
Reptilia FBXO34 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo34 35
  • 60.32 (n)
  • 52.59 (a)
Str.14993 35
(Danio rerio)
Actinopterygii si:ch73-132g21.5 35
  • 50.29 (n)
  • 43.58 (a)
FBXO34 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10603 36
  • 15 (a)
Species with no ortholog for FBXO34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO34 Gene

Gene Tree for FBXO34 (if available)
Gene Tree for FBXO34 (if available)

Paralogs for FBXO34 Gene

Paralogs for FBXO34 Gene

genes like me logo Genes that share paralogs with FBXO34: view

Variants for FBXO34 Gene

Sequence variations from dbSNP and Humsavar for FBXO34 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs943590 -- 55,271,878(-) CCGTA(A/G)GTGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs943591 -- 55,271,875(-) TAAGT(G/T)GGAGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs943592 -- 55,271,795(-) TCCCT(A/G)CCCGC intron-variant, upstream-variant-2KB
rs943593 -- 55,271,688(-) GGACC(A/C)GCGGG intron-variant, upstream-variant-2KB
rs1045002 - 55,351,799(+) TTCCA(A/T)TTTAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for FBXO34 Gene

Variant ID Type Subtype PubMed ID
nsv512361 CNV Loss 21212237
esv2748726 CNV Deletion 23290073
esv2657596 CNV Deletion 23128226
esv271549 CNV Insertion 20981092
esv272758 CNV Insertion 20981092
esv1218411 CNV Insertion 17803354
nsv84773 CNV Loss 16902084
esv2657865 CNV Deletion 23128226
nsv901957 CNV Gain 21882294

Relevant External Links for FBXO34 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO34 Gene

Disorders for FBXO34 Gene

No disorders were found for FBXO34 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FBXO34 Gene

Publications for FBXO34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  4. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for FBXO34 Gene

Sources for FBXO34 Gene

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