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Aliases for FBXO33 Gene

Aliases for FBXO33 Gene

  • F-Box Protein 33 2 3
  • Fbx33 3 4 6
  • F-Box Only Protein 33 2 3
  • BMND12 3 6
  • C14_5247 3

External Ids for FBXO33 Gene

Previous GeneCards Identifiers for FBXO33 Gene

  • GC14M033724
  • GC14M037856
  • GC14M038936
  • GC14M039866
  • GC14M019981

Summaries for FBXO33 Gene

Entrez Gene Summary for FBXO33 Gene

  • This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]

GeneCards Summary for FBXO33 Gene

FBXO33 (F-Box Protein 33) is a Protein Coding gene. Diseases associated with FBXO33 include osteoporosis.

UniProtKB/Swiss-Prot for FBXO33 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO33 Gene

Genomics for FBXO33 Gene

Regulatory Elements for FBXO33 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO33 Gene

Start:
39,396,373 bp from pter
End:
39,432,500 bp from pter
Size:
36,128 bases
Orientation:
Minus strand

Genomic View for FBXO33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO33 Gene

Proteins for FBXO33 Gene

  • Protein details for FBXO33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6M2-FBX33_HUMAN
    Recommended name:
    F-box only protein 33
    Protein Accession:
    Q7Z6M2
    Secondary Accessions:
    • Q6PIR2
    • Q86TR2
    • Q86YE0

    Protein attributes for FBXO33 Gene

    Size:
    555 amino acids
    Molecular mass:
    62630 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity).

neXtProt entry for FBXO33 Gene

Proteomics data for FBXO33 Gene at MOPED

Post-translational modifications for FBXO33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO33 Gene

Domains for FBXO33 Gene

Gene Families for FBXO33 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6M2

UniProtKB/Swiss-Prot:

FBX33_HUMAN :
  • Q7Z6M2
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO33: view

Function for FBXO33 Gene

Molecular function for FBXO33 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).

Gene Ontology (GO) - Molecular Function for FBXO33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16797541
genes like me logo Genes that share ontologies with FBXO33: view

Phenotypes for FBXO33 Gene

GenomeRNAi human phenotypes for FBXO33:
genes like me logo Genes that share phenotypes with FBXO33: view

Animal Model Products

CRISPR Products

miRNA for FBXO33 Gene

miRTarBase miRNAs that target FBXO33

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO33

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO33 Gene

Localization for FBXO33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO33 Gene COMPARTMENTS Subcellular localization image for FBXO33 gene
Compartment Confidence
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO33 Gene

Pathways for FBXO33 Gene

SuperPathways for FBXO33 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q7Z6M2-FBX33_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXO33: view

No data available for Pathways by source for FBXO33 Gene

Transcripts for FBXO33 Gene

mRNA/cDNA for FBXO33 Gene

Unigene Clusters for FBXO33 Gene

F-box protein 33:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO33

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO33 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for FBXO33 Gene

GeneLoc Exon Structure for
FBXO33
ECgene alternative splicing isoforms for
FBXO33

Expression for FBXO33 Gene

mRNA expression in normal human tissues for FBXO33 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO33 Gene

SOURCE GeneReport for Unigene cluster for FBXO33 Gene Hs.146632

genes like me logo Genes that share expressions with FBXO33: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO33 Gene

Orthologs for FBXO33 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO33 35
  • 99.64 (n)
  • 99.28 (a)
FBXO33 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO33 35
  • 93.39 (n)
  • 96.04 (a)
FBXO33 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO33 35
  • 91.17 (n)
  • 92.79 (a)
FBXO33 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo33 35
  • 90.33 (n)
  • 92.79 (a)
Fbxo33 16
Fbxo33 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO33 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO33 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo33 35
  • 90.65 (n)
  • 95.07 (a)
chicken
(Gallus gallus)
Aves FBXO33 35
  • 84.2 (n)
  • 89.38 (a)
FBXO33 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO33 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6980 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo33 35
  • 75.62 (n)
  • 80.61 (a)
Str.7357 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7780 35
zebrafish
(Danio rerio)
Actinopterygii FBXO33 36
  • 58 (a)
OneToOne
LOC567750 35
  • 63.83 (n)
  • 61.7 (a)
wufb78e03 35
fruit fly
(Drosophila melanogaster)
Insecta CG4911 36
  • 24 (a)
OneToOne
Species with no ortholog for FBXO33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO33 Gene

ENSEMBL:
Gene Tree for FBXO33 (if available)
TreeFam:
Gene Tree for FBXO33 (if available)

Paralogs for FBXO33 Gene

No data available for Paralogs for FBXO33 Gene

Variants for FBXO33 Gene

Sequence variations from dbSNP and Humsavar for FBXO33 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1056345 -- 39,396,470(-) TTTTT(A/T)AAATT utr-variant-3-prime
rs1955716 -- 39,430,245(+) GGAAA(C/T)AGAAT intron-variant
rs1955723 -- 39,433,231(+) TGGTA(C/T)CCCTA upstream-variant-2KB
rs1955724 -- 39,433,406(+) AGGGA(A/G)GCTGT upstream-variant-2KB
rs1955725 -- 39,434,462(+) TATAC(G/T)GCTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXO33 Gene

Variant ID Type Subtype PubMed ID
esv2748623 CNV Deletion 23290073
nsv832774 CNV Loss 17160897

Relevant External Links for FBXO33 Gene

HapMap Linkage Disequilibrium report
FBXO33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO33 Gene

Disorders for FBXO33 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FBXO33 Gene including...

Search for FBXO33 Gene in MalaCards »

Relevant External Links for FBXO33

Genetic Association Database (GAD)
FBXO33
Human Genome Epidemiology (HuGE) Navigator
FBXO33
genes like me logo Genes that share disorders with FBXO33: view

No data available for UniProtKB/Swiss-Prot for FBXO33 Gene

Publications for FBXO33 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death. (PMID: 16797541) Lutz M. … von Melchner H. (FEBS Lett. 2006) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FBXO33 Gene

Sources for FBXO33 Gene

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