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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO33 Gene

protein-coding   GIFtS: 49
GCID: GC14M039866

F-Box Protein 33

(Previous name: F-box only protein 33)
  Search for FBXO33
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 331 2
F-Box Only Protein 331 2
BMND122 5
FBX333 5
Fbx332
c14_52472

External Ids:    HGNC: 198331   Entrez Gene: 2541702   Ensembl: ENSG000001653557   OMIM: 6091035   UniProtKB: Q7Z6M23   

Export aliases for FBXO33 gene to outside databases

Previous GC identifers: GC14M033724 GC14M037856 GC14M038936 GC14M019981


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO33 Gene:
This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain
that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may
be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility
to osteoporosis.(provided by RefSeq, Sep 2010)

GeneCards Summary for FBXO33 Gene: 
FBXO33 (F-box protein 33) is a protein-coding gene.

UniProtKB/Swiss-Prot: FBX33_HUMAN, Q7Z6M2
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and
binds to phosphorylated target proteins. Recognizes YBX1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO33 gene promoter:
         Pax-5   ATF-2   XBP-1   Nkx2-5   C/EBPalpha   HOXA5   HSF2   c-Myb   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO33 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO33

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO33


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.1   Ensembl cytogenetic band:  14q21.1   HGNC cytogenetic band: 14q13.3

FBXO33 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO33 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M039866:  view genomic region     (about GC identifiers)

Start:
39,865,577 bp from pter      End:
39,901,704 bp from pter
Size:
36,128 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX33_HUMAN, Q7Z6M2 (See protein sequence)
Recommended Name: F-box only protein 33  
Size: 555 amino acids; 62630 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1,
RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By
similarity)
Secondary accessions: Q6PIR2 Q86TR2 Q86YE0

Explore the universe of human proteins at neXtProt for FBXO33: NX_Q7Z6M2

Explore proteomics data for FBXO33 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z6M2

  • FBXO33 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO33 Protein Expression
    REFSEQ proteins: NP_976046.1  
    ENSEMBL proteins: 
     ENSP00000298097   ENSP00000451277   ENSP00000450974  

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    Cloud-Clone Corp. Proteins for FBXO33 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q7Z6M2

    ProtoNet protein and cluster: Q7Z6M2

    UniProtKB/Swiss-Prot: FBX33_HUMAN, Q7Z6M2
    Similarity: Contains 1 F-box domain


    FBXO33 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX33_HUMAN, Q7Z6M2
    Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and
    binds to phosphorylated target proteins. Recognizes YBX1 (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16797541
         
    FBXO33 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO33:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO33 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO33

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO33 
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    8/132 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO33 (see all 132):
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO33 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: FBX33_HUMAN, Q7Z6M2
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO33

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for FBXO33 (Q7Z6M22, 3 ENSP000002980974) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    C1QBPQ070212, 3, ENSP000002256984MINT-2831634 I2D: score=1 STRING: ENSP00000225698
    CUL1Q136162, 3, ENSP000003268044MINT-2831398 I2D: score=1 STRING: ENSP00000326804
    HSPA9P386462, 3, ENSP000002971854MINT-2831598 I2D: score=1 STRING: ENSP00000297185
    IPO5O004102, 3, ENSP000002615744MINT-2831534 I2D: score=1 STRING: ENSP00000261574
    RBX1P628772, 3, ENSP000002162254MINT-2831467 I2D: score=1 STRING: ENSP00000216225
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    FBXO33 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO33 (FBX33)

    Search CenterWatch for drugs/clinical trials and news about FBXO33 / FBX33

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO33 gene: 
    NM_203301.3  

    Unigene Cluster for FBXO33:

    F-box protein 33
    Hs.146632  [show with all ESTs]
    Unigene Representative Sequence: NM_203301
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298097(uc001wvk.3) ENST00000554190 ENST00000554932
    miRNA
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    8/132 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO33 (see all 132):
    hsa-miR-411* hsa-miR-26a-2* hsa-miR-128 hsa-miR-342-3p hsa-miR-200b hsa-miR-92b hsa-miR-490-5p hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO33 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO33
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO33

    Additional mRNA sequence: 

    AK294140.1 BC030611.1 BC042535.1 BC053537.1 BC068566.1 BX248772.1 

    5 DOTS entries:

    DT.211025  DT.312076  DT.65287402  DT.120766501  DT.92418848 

    24/110 AceView cDNA sequences (see all 110):

    BQ775793 AI608739 BE326645 AI989795 AI686729 AI561122 AI207351 BC042535 
    BE222176 AI150979 CB137370 BM979476 AI695035 BQ880745 BC053537 AI253650 
    BC068566 AI219242 BM455686 BX248772 BX093575 BM988543 BQ020538 BM565461 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO33    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                          -     -               


    ECgene alternative splicing isoforms for FBXO33

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO33 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTACTTTTA
    FBXO33 Expression
    About this image


    See FBXO33 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO33

    SOURCE GeneReport for Unigene cluster: Hs.146632
        SABiosciences Expression via Pathway-Focused PCR Array including FBXO33: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO33 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo331 , 5 F-box protein 331, 5 90.75(n)1
    93.51(a)1
      12 (26.03 cM)5
    706111  NM_001033156.41  NP_001028328.21 
     592006555 
    chicken
    (Gallus gallus)
    Aves FBXO331 F-box protein 33 84.2(n)
    89.38(a)
      428887  XM_426443.3  XP_426443.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO336
    Uncharacterized protein
    78(a)
    1 ↔ 1
    1(23855650-23877893)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69802 Xenopus laevis transcribed sequences 89.95(n)    AW640340.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb78e032 Transcribed sequences 82.38(n)    57043160 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49111 CG4911 40.78(n)
    29.09(a)
      39043  NM_140028.1  NP_648285.1 


    ENSEMBL Gene Tree for FBXO33 (if available)
    TreeFam Gene Tree for FBXO33 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/786 SNPs in FBXO33 are shown (see all 786)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503479501,2
    C--19995903(+) GACTT-/CCCCCC 1 -- int10--------
    rs1404221401,2
    --20006108(+) CACAC-/ACAC  
      ACACAA
    ACACA
    1 -- int10--------
    rs2005571641,2
    C--20006117(+) TGTGTA/C/G/
            
    TGTGT
    1 -- int10--------
    rs2011104941,2
    C--20862238(+) AAGGGG/TGGGGG 1 -- ds50010--------
    rs124330451,2
    C,H--20862241(+) GGTGGC/GGGGGG 1 -- ds50011Minor allele frequency- G:0.00WA 2
    rs2009854071,2
    C--20862252(+) GGGGGC/GGGGGG 1 -- ds50010--------
    rs1896529681,2
    --20862258(+) GGGGGC/GGCGTC 1 -- ds50010--------
    rs620007201,2
    C--20862265(+) CGTCTA/CCAAAG 1 -- ds50014Minor allele frequency- C:0.09NA WA EA 360
    rs3737004881,2
    C--20862394(+) CCTGCA/GCCTCT 1 -- ds50010--------
    rs171091701,2
    C,F,H--20862430(+) TTGGTG/AGCTGT 1 -- ds50018Minor allele frequency- A:0.04NA NS EA WA 678

    HapMap Linkage Disequilibrium report for FBXO33 (39865577 - 39901704 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXO33:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748623CNV Deletion23290073
    nsv832774CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO33
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXO33 for disorders           About MalaCards
    OMIM gene information: 609103   
    OMIM disorders: 612560  

    FBXO33 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO33
    Human Genome Epidemiology (HuGE) Navigator: FBXO33 (1 document)

    Export disorders for FBXO33 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO33 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with FBXO33)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death. (PubMed id 16797541)1, 9 Lutz M.... von Melchner H. (2006)
    4. Genome wide association study for plasma levels of nat ural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA pr oject. (PubMed id 22443383)4 Oudot-Mellakh T....Morange P.E. (2012)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    7. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    9. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (2007)
    10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 254170 HGNC: 19833 AceView: FBXO33 Ensembl:ENSG00000165355 euGenes: HUgn254170
    ECgene: FBXO33 H-InvDB: FBXO33

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO33 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO33 gene:
    Search GeneIP for patents involving FBXO33

    GeneCards and IP:
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