Aliases for FBXO33 Gene
Aliases for FBXO33 Gene
External Ids for FBXO33 Gene
- HGNC: 19833
- Entrez Gene: 254170
- Ensembl: ENSG00000165355
- OMIM: 609103
- UniProtKB: Q7Z6M2
Previous GeneCards Identifiers for FBXO33 Gene
- GC14M033724
- GC14M037856
- GC14M038936
- GC14M039866
- GC14M019981
Summaries for FBXO33 Gene
-
This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
GeneCards Summary for FBXO33 Gene
FBXO33 (F-Box Protein 33) is a Protein Coding gene. Diseases associated with FBXO33 include Attention Deficit-Hyperactivity Disorder.
UniProtKB/Swiss-Prot for FBXO33 Gene
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO33 Gene
Genomics for FBXO33 Gene
Regulatory Elements for FBXO33 Gene
Enhancers for FBXO33 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO33 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO33 gene promoter:
Regulatory Element Products
Genomic Location for FBXO33 Gene
- Chromosome:
- 14
- Start:
- 39,396,373 bp from pter
- End:
- 39,432,500 bp from pter
- Size:
- 36,128 bases
- Orientation:
- Minus strand
Genomic View for FBXO33 Gene
Genes around FBXO33 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q21.1 by Ensembl
- 14q21.1 by Entrez Gene
- 14q21.1 by HGNC
FBXO33 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO33 Gene
Proteins for FBXO33 Gene
-
Protein details for FBXO33 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z6M2-FBX33_HUMAN
- Recommended name:
- F-box only protein 33
- Protein Accession:
- Q7Z6M2
- Q6PIR2
- Q86TR2
- Q86YE0
Protein attributes for FBXO33 Gene
- Size:
- 555 amino acids
- Molecular mass:
- 62630 Da
- Quaternary structure:
-
- Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity).
Protein Expression for FBXO33 Gene
Post-translational modifications for FBXO33 Gene
Other Protein References for FBXO33 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO33
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- Invitrogen Antibodies for FBXO33
- antibodies-online Antibodies for FBXO33: See all 21
- Search GeneTex for Antibodies for FBXO33
Protein Products
-
OriGene Purified Proteins for FBXO33
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- antibodies-online Proteins for FBXO33: See all 6
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Assay Products
- antibodies-online Kits for FBXO33: See all 15
No data available for DME Specific Peptides for FBXO33 Gene
Domains & Families for FBXO33 Gene
Gene Families for FBXO33 Gene
- HGNC:
Protein Domains for FBXO33 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO33 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO33 Gene
Function for FBXO33 Gene
Molecular function for FBXO33 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16797541 |
Phenotypes for FBXO33 Gene
- MGI mutant phenotypes for FBXO33:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXO33:
Animal Models for FBXO33 Gene
- MGI Knock Outs for FBXO33:
-
- Fbxo33 tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO33 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO33 gene
- Search ViGene Biosciences for FBXO33
CRISPR Products
-
OriGene CRISPR knockouts for FBXO33
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO33
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miRNA for FBXO33 Gene
- miRTarBase miRNAs that target FBXO33
miRNA Products
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Inhibitory RNA Products
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-
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Cell Line Products
-
Horizon Cell Lines for FBXO33
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO33 Gene
Localization for FBXO33 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO33 Gene
Pathways & Interactions for FBXO33 Gene
No Data Available
UniProtKB/Swiss-Prot Q7Z6M2-FBX33_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXO33 Gene
Selected Interacting proteins:
Q7Z6M2-FBX33_HUMAN
ENSP00000298097
for FBXO33 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FBXO33 Gene
Transcripts for FBXO33 Gene
mRNA/cDNA for FBXO33 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (110) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO33
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO33
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miRNA Products
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Inhibitory RNA Products
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-
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | |||||||||||||||
| SP3: | |||||||||||||||
| SP4: | - | - |
Expression for FBXO33 Gene
This gene is overexpressed in Adrenal (21.3), Kidney (17.6), Heart (16.1), Peripheral blood mononuclear cells (6.7), and Adipocyte (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO33 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO33 Gene:
FBXO33SOURCE GeneReport for Unigene cluster for FBXO33 Gene:
Hs.146632Evidence on tissue expression from TISSUES for FBXO33 Gene
- Nervous system(4.4)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for FBXO33
-
OriGene qPCR primer pairs and template standards for FBXO33
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO33 Gene
Orthologs for FBXO33 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO33 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO33 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO33 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo33 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO33 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO33 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO33 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO33 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo33 34 |
|
||
| Str.7357 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6980 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC567750 34 |
|
||
| FBXO33 35 |
|
OneToOne | |||
| wufb78e03 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7780 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG4911 35 |
|
OneToOne |
- Species where no ortholog for FBXO33 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO33 Gene
No data available for Paralogs for FBXO33 Gene
Variants for FBXO33 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025546 | -- | 39,433,317(+) | GAAGT(C/G/T)AGAAA | intron-variant, upstream-variant-2KB | |
| rs1000152701 | -- | 39,410,085(+) | AAGAG(C/T)AGGCA | intron-variant | |
| rs1000175848 | -- | 39,403,411(+) | GCCAA(A/C)ATGGC | intron-variant | |
| rs1000231087 | -- | 39,397,469(+) | CCATA(C/T)TGATA | utr-variant-3-prime | |
| rs1000238273 | -- | 39,407,046(+) | TATGA(C/G)TTCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2748623 | CNV | deletion | 23290073 |
| esv3581127 | CNV | loss | 25503493 |
| esv3584304 | CNV | gain | 25503493 |
| nsv832774 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.81;
47.63% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO33 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO33
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO33 Gene
Disorders for FBXO33 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| attention deficit-hyperactivity disorder |
|
|
Search FBXO33 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FBXO33
No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO33 Gene
Publications for FBXO33 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death. (PMID: 16797541) Lutz M. … von Melchner H. (FEBS Lett. 2006) 3 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
- Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder. (PMID: 25284319) SA!nchez-Mora C. … RibasAcs M. (Neuropsychopharmacology 2015) 3 64
Products for FBXO33 Gene
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- antibodies-online Antibodies for FBXO33: See all 21
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO33 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (141) ENCODE
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- (148) SNPedia
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer