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Aliases for FBXO33 Gene

Aliases for FBXO33 Gene

  • F-Box Protein 33 2 3 5
  • Fbx33 3 4
  • F-Box Only Protein 33 2
  • C14_5247 3
  • BMND12 3

External Ids for FBXO33 Gene

Previous GeneCards Identifiers for FBXO33 Gene

  • GC14M033724
  • GC14M037856
  • GC14M038936
  • GC14M039866
  • GC14M019981

Summaries for FBXO33 Gene

Entrez Gene Summary for FBXO33 Gene

  • This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]

GeneCards Summary for FBXO33 Gene

FBXO33 (F-Box Protein 33) is a Protein Coding gene. Diseases associated with FBXO33 include Bone Mineral Density Qtl 12, Osteoporosis.

UniProtKB/Swiss-Prot for FBXO33 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO33 Gene

Genomics for FBXO33 Gene

Regulatory Elements for FBXO33 Gene

Enhancers for FBXO33 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO33 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO33 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO33 Gene

39,396,373 bp from pter
39,432,500 bp from pter
36,128 bases
Minus strand

Genomic View for FBXO33 Gene

Genes around FBXO33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO33 Gene

Proteins for FBXO33 Gene

  • Protein details for FBXO33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 33
    Protein Accession:
    Secondary Accessions:
    • Q6PIR2
    • Q86TR2
    • Q86YE0

    Protein attributes for FBXO33 Gene

    555 amino acids
    Molecular mass:
    62630 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1 and CUL1 (By similarity).

neXtProt entry for FBXO33 Gene

Proteomics data for FBXO33 Gene at MOPED

Post-translational modifications for FBXO33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO33 Gene

Domains & Families for FBXO33 Gene

Gene Families for FBXO33 Gene

Protein Domains for FBXO33 Gene


Suggested Antigen Peptide Sequences for FBXO33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO33: view

Function for FBXO33 Gene

Molecular function for FBXO33 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
genes like me logo Genes that share phenotypes with FBXO33: view

Animal Models for FBXO33 Gene

MGI Knock Outs for FBXO33:

Animal Model Products

miRNA for FBXO33 Gene

miRTarBase miRNAs that target FBXO33

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO33 Gene

Localization for FBXO33 Gene

Subcellular locations from

Jensen Localization Image for FBXO33 Gene COMPARTMENTS Subcellular localization image for FBXO33 gene
Compartment Confidence
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO33 Gene

Pathways & Interactions for FBXO33 Gene

SuperPathways for FBXO33 Gene

No Data Available

UniProtKB/Swiss-Prot Q7Z6M2-FBX33_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO33 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO33 Gene

Drugs & Compounds for FBXO33 Gene

No Compound Related Data Available

Transcripts for FBXO33 Gene

mRNA/cDNA for FBXO33 Gene

Unigene Clusters for FBXO33 Gene

F-box protein 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO33 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b
SP4: - -

Relevant External Links for FBXO33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO33 Gene

mRNA expression in normal human tissues for FBXO33 Gene

Protein differential expression in normal tissues from HIPED for FBXO33 Gene

This gene is overexpressed in Adrenal (21.3), Kidney (17.6), Heart (16.1), Peripheral blood mononuclear cells (6.7), and Adipocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO33 Gene

SOURCE GeneReport for Unigene cluster for FBXO33 Gene Hs.146632

genes like me logo Genes that share expression patterns with FBXO33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXO33 Gene

Orthologs for FBXO33 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO33 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO33 35
  • 93.39 (n)
  • 96.04 (a)
FBXO33 36
  • 95 (a)
(Canis familiaris)
Mammalia FBXO33 35
  • 91.17 (n)
  • 92.79 (a)
FBXO33 36
  • 97 (a)
(Mus musculus)
Mammalia Fbxo33 35
  • 90.33 (n)
  • 92.79 (a)
Fbxo33 16
Fbxo33 36
  • 91 (a)
(Pan troglodytes)
Mammalia FBXO33 35
  • 99.64 (n)
  • 99.28 (a)
FBXO33 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxo33 35
  • 90.65 (n)
  • 95.07 (a)
(Monodelphis domestica)
Mammalia FBXO33 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO33 36
  • 80 (a)
(Gallus gallus)
Aves FBXO33 35
  • 84.2 (n)
  • 89.38 (a)
FBXO33 36
  • 90 (a)
(Anolis carolinensis)
Reptilia FBXO33 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo33 35
  • 75.62 (n)
  • 80.61 (a)
Str.7357 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6980 35
(Danio rerio)
Actinopterygii LOC567750 35
  • 63.83 (n)
  • 61.7 (a)
wufb78e03 35
FBXO33 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7780 35
fruit fly
(Drosophila melanogaster)
Insecta CG4911 36
  • 24 (a)
Species with no ortholog for FBXO33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO33 Gene

Gene Tree for FBXO33 (if available)
Gene Tree for FBXO33 (if available)

Paralogs for FBXO33 Gene

No data available for Paralogs for FBXO33 Gene

Variants for FBXO33 Gene

Sequence variations from dbSNP and Humsavar for FBXO33 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140854 -- 39,428,944(+) GGAAT(C/T)TCTGA intron-variant
rs7142748 -- 39,403,489(+) TGAAC(C/T)GGGAG intron-variant
rs8003397 -- 39,422,255(+) tccat(C/T)tccaa intron-variant
rs8003621 -- 39,422,190(+) gaggc(A/G)gaggt intron-variant
rs8019328 -- 39,421,341(+) GAGCA(G/T)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO33 Gene

Variant ID Type Subtype PubMed ID
esv2748623 CNV Deletion 23290073
nsv832774 CNV Loss 17160897

Variation tolerance for FBXO33 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO33 Gene

Disorders for FBXO33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO33 Gene - From: OMIM

Disorder Aliases PubMed IDs
bone mineral density qtl 12, osteoporosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO33

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXO33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO33 Gene

Publications for FBXO33 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death. (PMID: 16797541) Lutz M. … von Melchner H. (FEBS Lett. 2006) 3 23
  3. Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder. (PMID: 25284319) SA!nchez-Mora C. … RibasAcs M. (Neuropsychopharmacology 2015) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FBXO33 Gene

Sources for FBXO33 Gene