External Ids for FBXO33 Gene
Previous GeneCards Identifiers for FBXO33 Gene
This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]
GeneCards Summary for FBXO33 Gene
FBXO33 (F-Box Protein 33) is a Protein Coding gene. Diseases associated with FBXO33 include bone mineral density qtl 12, osteoporosis.
UniProtKB/Swiss-Prot for FBXO33 Gene
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).