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FBXO32 Gene

protein-coding   GIFtS: 53
GCID: GC08M124510

F-Box Protein 32

(Previous name: F-box only protein 32)
  See FBXO32-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 321 2     atrogin-12
F-Box Only Protein 321 2     Atrogin-13
Muscle Atrophy F-Box Protein2 3     ATROGIN15
MAFbx2 3     FLJ324245
Fbx322     MAFBX5
Atrogin 12     

External Ids:    HGNC: 167311   Entrez Gene: 1149072   Ensembl: ENSG000001568047   OMIM: 6066045   UniProtKB: Q969P53   

Export aliases for FBXO32 gene to outside databases

Previous GC identifers: GC08M123657 GC08M124573 GC08M124184 GC08M124471 GC08M124584 GC08M119840


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO32 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle
atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a
potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Jun 2011)

GeneCards Summary for FBXO32 Gene:
FBXO32 (F-box protein 32) is a protein-coding gene. Diseases associated with FBXO32 include myopathy of critical illness. An important paralog of this gene is FBXO25.

UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1

Gene Wiki entry for FBXO32 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO32 gene promoter:
         FOXO1a   CUTL1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXO32 promoter sequence
   Search Chromatin IP Primers for FBXO32

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

FBXO32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO32 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124510:  view genomic region     (about GC identifiers)

Start:
124,510,127 bp from pter      End:
124,553,493 bp from pter
Size:
43,367 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5 (See protein sequence)
Recommended Name: F-box only protein 32  
Size: 355 amino acids; 41637 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1,
RBX1 and FBXO32
Secondary accessions: A4KYM0
Alternative splicing: 2 isoforms:  Q969P5-1   Q969P5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO32: NX_Q969P5

Explore proteomics data for FBXO32 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229392.1  NP_478136.1  NP_680482.1  

    ENSEMBL proteins: 
     ENSP00000428205   ENSP00000390790  

    FBXO32 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FBXO32
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    Novus Biologicals FBXO32 Proteins
    Novus Biologicals FBXO32 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO32

     
    Search eBioscience for Proteins for FBXO32 

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    LSBio Antibodies in human, mouse, rat for FBXO32

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q969P5

    ProtoNet protein and cluster: Q969P5

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO32           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX32_HUMAN, Q969P5
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
    and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18354498
         
    Find genes that share ontologies with FBXO32           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fbxo32):
     muscle 

    Find genes that share phenotypes with FBXO32           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO32
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO32
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    miRNA
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    Block miRNA regulation of human, mouse, rat FBXO32 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO32 (see all 101):
    hsa-miR-548j hsa-miR-642a hsa-miR-938 hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFBXO32 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO32
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO32

    Gene Editing
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    OriGene ORF clones in mouse, rat for FBXO32
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    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO32 (NM_058229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO32

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO32


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX32_HUMAN, Q969P5: Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    lysosome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0030018Z disc IEA--

    Find genes that share ontologies with FBXO32           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXO32 About    
    See pathways by source

    SuperPathContained pathways About
    1Monoamine Transport
    Monoamine Transport
    2FoxO signaling pathway
    FoxO signaling pathway
    3FoxO family signaling
    FoxO family signaling


    Find genes that share SuperPaths with FBXO32           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for FBXO32
        Monoamine Transport
    FoxO family signaling


    1 Kegg Pathway  (Kegg details for FBXO32):
        FoxO signaling pathway

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO32: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO32

    5 Interacting proteins for FBXO32 (Q969P51, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003031, 2, 3EBI-2932534,EBI-711990 MINT-6613268 MINT-6613284 MINT-6613316 MINT-6613441 MINT-6613301 MINT-6613335 MINT-6613420 I2D: score=3 
    SKP1P632083I2D: score=3 
    EIF3AQ141523I2D: score=1 
    MLH1P406923I2D: score=1 
    MYOGP151733I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014894response to denervation involved in regulation of muscle adaptation ISS--
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with FBXO32           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO32 (FBX32)

    3 Novoseek inferred chemical compound relationships for FBXO32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 41.2 3 19533653 (1), 19927034 (1), 17418104 (1)
    dexamethasone 18.9 2 15550386 (1), 19631210 (1)
    glycogen 17.1 5 19533653 (1), 16916907 (1), 17478621 (1)



    Find genes that share compounds with FBXO32           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO32 gene (3 alternative transcripts): 
    NM_001242463.1  NM_058229.3  NM_148177.2  

    Unigene Cluster for FBXO32:

    F-box protein 32
    Hs.403933  [show with all ESTs]
    Unigene Representative Sequence: NM_058229
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517956(uc003yqp.2 uc003yqr.3 uc010mdk.3) ENST00000524000
    ENST00000287396 ENST00000443022 ENST00000521719 ENST00000520511
    miRNA
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    Block miRNA regulation of human, mouse, rat FBXO32 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO32 (see all 101):
    hsa-miR-548j hsa-miR-642a hsa-miR-938 hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFBXO32 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO32
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO32
    Clone
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    OriGene clones in human, mouse for FBXO32 (see all 13)
    OriGene ORF clones in mouse, rat for FBXO32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO32 (NM_058229)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO32
    Primer
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    OriGene qPCR primer pairs and template standards for FBXO32
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO32
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO32
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO32
      QuantiFast Probe-based Assays in human, mouse, rat FBXO32

    Additional mRNA sequence: 

    AJ420108.1 AK023391.1 AK056986.1 AK096904.1 AK124390.1 AK125888.1 AY059629.1 BC022416.1 
    BC024030.2 BC100020.1 BC120963.1 BC120964.1 EF143260.1 

    9 DOTS entries:

    DT.95369675  DT.454988  DT.91663722  DT.100817561  DT.207029  DT.100817563  DT.100815255  DT.100817565 
    DT.121478817 

    Selected AceView cDNA sequences (see all 265):

    BF439972 AI911683 AU134506 AA884364 AI694613 AJ420108 AA256464 AI399801 
    AA233299 AI287610 AI913594 AA953025 BQ930818 NM_058229 AW295245 NM_148177 
    BM839780 AI217042 AA256804 BQ772828 CA397320 AA302183 AI445387 AI075070 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGACAT
    FBXO32 Expression
    About this image


    FBXO32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Cumulus Cells Antral Follicle
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Eye (Sensory Organs)
             AII Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
             Testis Interstitium
     
     Neurons
             AII Amacrine Cells Inner Nuclear Layer
    FBXO32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO32 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.403933

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Tissue specificity: Specifically expressed in cardiac and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO32: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat FBXO32
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXO32 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo321 , 5 F-box protein 321, 5 91.17(n)1
    96.62(a)1
      15 (24.43 cM)5
    677311  NM_026346.31  NP_080622.11 
     581758795 
    chicken
    (Gallus gallus)
    Aves FBXO321 F-box protein 32 84.04(n)
    92.68(a)
      420343  NM_001030956.1  NP_001026127.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO326
    F-box protein 32
    90(a)
    1 ↔ 1
    4(6740590-6773788)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo321 F-box protein 32 77.62(n)
    84.42(a)
      100496585  XM_002941397.2  XP_002941443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564792 similar to F-box only protein 32 77.02(n)   393891  BC052112.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116586
    --
    27(a)
    1 → many
    3L(11692596-11701653)
    worm
    (Caenorhabditis elegans)
    Secernentea mfb-16
    Protein MFB-1 (mfb-1) mRNA, complete cds
    24(a)
    1 → many
    I(8779737-8785415) WBGene00008439


    ENSEMBL Gene Tree for FBXO32 (if available)
    TreeFam Gene Tree for FBXO32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO32 gene
    FBXO252  
    1 SIMAP similar gene for FBXO32 using alignment to 4 protein entries:     FBX32_HUMAN (see all proteins):
    FBXO25

    Find genes that share paralogs with FBXO32           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO32 (see all 914)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70133751,2
    C,F--124509660(+) cactgC/Tacctg 3 -- ds500112Minor allele frequency- T:0.10NA WA CSA EA 375
    rs1453340171,2
    --124509750(+) AAAACA/CACACA 3 -- ds50010--------
    rs1479893011,2
    --124509775(+) AATTTC/GTGTCT 3 -- ds50010--------
    rs737059431,2
    C,F--124509806(+) GTGCCT/GTGCAC 3 -- ds50012Minor allele frequency- G:0.10WA 120
    rs1416286971,2
    --124510168(+) CAAAAG/TTTTTT 3 -- ut310--------
    rs22809151,2
    C,F,H--124510274(+) TCACAC/TAATAT 3 -- ut3119Minor allele frequency- T:0.16EA NA NS WA 3962
    rs1906355051,2
    --124510293(+) CATCTC/TTGCAT 3 -- ut310--------
    rs1827586461,2
    --124510342(+) ACCCCC/TTCTAA 3 -- ut310--------
    rs286676631,2
    --124510356(+) TTTTCA/CTTTAA 3 -- ut310--------
    rs749657491,2
    C,F--124510409(+) TATACG/ACCCAC 3 -- ut311Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for FBXO32 (124510127 - 124553493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FBXO32:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831450CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO32
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606604    OMIM disorders: --

    1 disease for FBXO32:    
    About MalaCards
    myopathy of critical illness

    2 diseases from the University of Copenhagen DISEASES database for FBXO32:
    Muscular atrophy     Myopathy of critical illness

    Find genes that share disorders with FBXO32           About GenesLikeMe

    3 Novoseek inferred disease relationships for FBXO32 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atrophy 79.9 58 16507768 (4), 17478621 (2), 17992259 (2), 18599544 (2) (see all 29)
    hypertrophy 55.5 11 18235241 (2), 15550386 (1), 19117950 (1), 16916907 (1) (see all 6)
    aids 0 1 18583931 (1)

    Genetic Association Database (GAD): FBXO32
    Human Genome Epidemiology (HuGE) Navigator: FBXO32 (2 documents)

    Export disorders for FBXO32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO32 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with FBXO32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ubiquitin ligases required for skeletal muscle atrophy. (PubMed id 11679633)1, 2, 3 Bodine S.C.... Glass D.J. (Science 2001)
    2. Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1. (PubMed id 22249105)1, 2 Julie L.C.... Leibovitch S.A. (FEBS Lett. 2012)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. (PubMed id 11717410)1, 3 Gomes M.D....Goldberg A.L. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    6. Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. (PubMed id 19117950)1, 9 Xie P....Li H. (J. Biol. Chem. 2009)
    7. Expression of the muscle atrophy factor muscle atrophy F-box is suppressed by testosterone. (PubMed id 18599544)1, 9 Zhao W....Cardozo C.P. (Endocrinology 2008)
    8. Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase. (PubMed id 15531760)2, 9 Tintignac L.A....Leibovitch S.A. (J. Biol. Chem. 2005)
    9. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. (PubMed id 17992259)1, 9 Hanai J....Lecker S.H. (J. Clin. Invest. 2007)
    10. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. (PubMed id 17478621)1, 9 Doucet M....Maltais F. (Am. J. Respir. Crit. Care Med. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 114907 HGNC: 16731 AceView: FBXO32 Ensembl:ENSG00000156804 euGenes: HUgn114907
    ECgene: FBXO32 Kegg: 114907 H-InvDB: FBXO32

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FBXO32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FBXO32 gene:
    Search GeneIP for patents involving FBXO32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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