Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO32 Gene

protein-coding   GIFtS: 51
GCID: GC08M124510

F-box protein 32

(Previous name: F-box only protein 32 )
 Explore 27 diseases affiliated with
FBXO32 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FBXO32    

Aliases
for FBXO32 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
F-Box Protein 321 2     Atrogin 12
MAFbx1 2 3     Atrogin-13
Fbx321 2     Atrogin-13
F-Box Only Protein 321 2     FLJ324245
Muscle Atrophy F-Box Protein2 3     MAFBX5
ATROGIN11 5     

External Ids:    HGNC: 167311   Entrez Gene: 1149072   Ensembl: ENSG000001568047   OMIM: 6066045   UniProtKB: Q969P53   

Export aliases for FBXO32 gene to outside databases

Previous GC identifers: GC08M123657 GC08M124573 GC08M124184 GC08M124471 GC08M124584 GC08M119840


Summaries
for FBXO32 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FBXO32:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs
class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in
this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of
muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by
RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds
to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1

Gene Wiki entry for FBXO32


Genomic Views
for FBXO32 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO32 gene promoter:
         FOXO1a   CUTL1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXO32 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

FBXO32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO32 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124510:  view genomic region     (about GC identifiers)

Start:
 124,510,129 bp from pter      End:
 124,553,446 bp from pter
Size:
 43,318 bases      Orientation:
 minus strand

Proteins
for FBXO32 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5 (See protein sequence)
Recommended Name: F-box only protein 32  
Size: 355 amino acids; 41637 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1
and FBXO32
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus
Secondary accessions: A4KYM0
Alternative splicing: 2 isoforms:  Q969P5-1   Q969P5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO32: NX_Q969P5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969P5

    • FBXO32 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001229392.1  NP_478136.1  NP_680482.1  

    ENSEMBL proteins: 
     ENSP00000428205   ENSP00000390790  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): FBXO32
    OriGene Custom Protein Services for FBXO32 
    GenScript Custom Purified and Recombinant Proteins Services for FBXO32
    Novus Biologicals FBXO32 Proteins
    Novus Biologicals FBXO32 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBXO32

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    FBXO32 for ontologies           About GeneDecksing



    FBXO32 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: FBXO32
    OriGene Custom Antibody Services for FBXO32 
    GenScript Custom Superior Antibodies Services for FBXO32
    Novus Biologicals FBXO32 Antibodies
    Search for Antibodies for FBXO32 at Abcam  
    Uscn Antibodies for FBXO32
    ThermoFisher Antibodies for FBXO32

    Assay Products for FBXO32: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXO32
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FBXO32

    Protein Domains /
    Families
    for FBXO32 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FBXO32 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q969P5

    ProtoNet protein and cluster: Q969P5

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Similarity: Contains 1 F-box domain


    Function
    for FBXO32 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds
    to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): FBXO32
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO32
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO32 (see all 101):
    hsa-miR-548j hsa-miR-642a hsa-miR-938 hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: FBXO32 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO32 (see all 7)
    OriGene shRNA RFP: FBXO32
    OriGene siRNA: FBXO32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO32

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FBXO32

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO32 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO32 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO32 (NM_058229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO32 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FBXO32
    Search LifeMap BioReagents cell lines for FBXO32

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO32

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fbxo32):
     muscle 

    FBXO32 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FBXO32 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Monoamine Transport
    		Monoamine Transport1.00
    2FoxO family signaling
    		FoxO family signaling1.00


    2 BioSystems Pathways for FBXO32 
        Monoamine Transport
    FoxO family signaling


    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO32

    5 Interacting proteins for FBXO32 (Q969P52, 3) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003032, 3MINT-6613268 MINT-6613284 MINT-6613316 MINT-6613441 MINT-6613301 MINT-6613335 MINT-6613420 I2D: score=3 
    SKP1P632083I2D: score=3 
    EIF3AQ141523I2D: score=1 
    MLH1P406923I2D: score=1 
    MYOGP151733I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014889muscle atrophy ----
    GO:0016567protein ubiquitination IEA--


    FBXO32 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FBXO32 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FBXO32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO32
    3 Novoseek chemical compound relationships for FBXO32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 41.2 3 19533653 (1), 19927034 (1), 17418104 (1)
    dexamethasone 18.9 2 15550386 (1), 19631210 (1)
    glycogen 17.1 5 19533653 (1), 16916907 (1), 17478621 (1)

    Search CenterWatch for drugs/clinical trials and news about FBXO32 / FBX32 

    Transcripts
    for FBXO32 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FBXO32 gene (3 alternative transcripts): 
    NM_001242463.1  NM_058229.3  NM_148177.2  

    Unigene Cluster for FBXO32:

    F-box protein 32
    Hs.403933  [show with all ESTs]
    Unigene Representative Sequence: NM_058229
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517956(uc003yqp.2 uc003yqr.3 uc010mdk.3) ENST00000524000
    ENST00000287396 ENST00000443022 ENST00000521719 ENST00000520511

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): FBXO32
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO32
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO32 (see all 101):
    hsa-miR-548j hsa-miR-642a hsa-miR-938 hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: FBXO32 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO32 (see all 7)
    OriGene shRNA RFP: FBXO32
    OriGene siRNA: FBXO32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO32
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO32 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO32 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO32 (NM_058229)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO32 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO32
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO32
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO32
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO32

    Additional cDNA sequence: 

    AJ420108.1 AK023391.1 AK056986.1 AK096904.1 AK124390.1 AK125888.1 AY059629.1 BC022416.1 
    BC024030.2 BC100020.1 BC120963.1 BC120964.1 EF143260.1 

    9 DOTS entries:

    DT.95369675  DT.454988  DT.91663722  DT.100817561  DT.207029  DT.100817563  DT.100815255  DT.100817565 
    DT.121478817 

    24/265 AceView cDNA sequences (see all 265):

    AW081588 BC022416 BF432678 AI077844 BU608946 AI581780 BX955246 BU689512 
    AI289755 BM763027 AK124390 BG674545 AA862045 AK056986 AI858228 AI913594 
    AI287610 AA953025 NM_148177 NM_058229 BQ930818 BM839780 AI217042 AA256804 

    GeneLoc Exon Structure


    Expression
    for FBXO32 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAGGACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FBXO32 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    OvaryAntral FollicleCumulus CellsOvary
    OvaryAntral FollicleCumulus CellsOvary
    KidneyInterstitial StromaKidney
    Spinal CordPresumptive Spinal CordSpinal Cord
    TestisTestis InterstitiumTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    Genevestigator expression for FBXO32

    SOURCE GeneReport for Unigene cluster: Hs.403933

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Tissue specificity: Specifically expressed in cardiac and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO32: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO32
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO32
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO32
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO32
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO32

    Orthologs
    for FBXO32 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FBXO32 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fbxo321 , 5 F-box protein 321, 5 91.17(n)1
    96.62(a)1    		   15 (24.43 cM)5
    677311  NM_026346.31  NP_080622.11 
     581758795 
    chicken
    (Gallus gallus)    		 Aves FBXO321 F-box protein 32 84.04(n)
    92.68(a)    		   420343  NM_001030956.1  NP_001026127.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FBXO326
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(6741058-6773788)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc564792 similar to F-box only protein 32 77.02(n)   393891  BC052112.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG116581 CG11658 48.43(n)
    31.27(a)    		   39319  NM_140241.2  NP_648498.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mfb-16
    		 MAFBx (F-box protein) homolog family member (mfb-1...
    		 25(a)
    		 1 → many
    		 I(8779731-8785409)


    ENSEMBL Gene Tree for FBXO32 (if available)
    TreeFam Gene Tree for FBXO32 (if available) 

    Paralogs
    for FBXO32 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO32 gene
    FBXO252  
    1 SIMAP similar gene for FBXO32 using alignment to 4 protein entries:     FBX32_HUMAN (see all proteins):
    FBXO25

    FBXO32 for paralogs           About GeneDecksing



    Genomic Variants
    for FBXO32 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/743 NCBI SNPs in FBXO32 are shown (see all 743)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs70133751,2
    		C,F,--124509660(+) CACTGC/TACCTG 3 -- ds500112Minor allele frequency- T:0.10NA WA CSA EA 375
    rs1453340171,2
    		--124509750(+) AAAACA/CACACA 3 -- ds50010--------
    rs1479893011,2
    		--124509775(+) AATTTC/GTGTCT 3 -- ds50010--------
    rs737059431,2
    		C,--124509806(+) GTGCCT/GTGCAC 3 -- ds50012Minor allele frequency- G:0.10WA 120
    rs1416286971,2
    		--124510168(+) CAAAAG/TTTTTT 3 -- ut310--------
    rs22809151,2
    		C,F,H,--124510274(+) TCACAC/TAATAT 3 -- ut3119Minor allele frequency- T:0.16EA NA NS WA 3962
    rs1906355051,2
    		--124510293(+) CATCTC/TTGCAT 3 -- ut310--------
    rs1827586461,2
    		--124510342(+) ACCCCC/TTCTAA 3 -- ut310--------
    rs286676631,2
    		--124510356(+) TTTTCA/CTTTAA 3 -- ut310--------
    rs749657491,2
    		F,--124510409(+) TATACG/ACCCAC 3 -- ut311Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for FBXO32 (124510129 - 124553446 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FBXO32: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO32
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO32

    Disorders / Diseases
    for FBXO32 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FBXO32 for disorders           About GeneDecksing

    OMIM gene information: 606604    OMIM disorders: --

    20/27 diseases for FBXO32 (see all 27):    About MalaCards
    spinal cord injury    acquired immunodeficiency syndrome    duchenne muscular dystrophy    amyotrophic lateral sclerosis
    chronic obstructive pulmonary disease    muscular dystrophy    lateral sclerosis    muscle hypertrophy
    primary hyperparathyroidism    muscular atrophy    myocardial infarction    lymphopenia
    hyperparathyroidism    cystic fibrosis    pulmonary disease    uremia
    myopathy    myositis    hyperthyroidism    kidney disease

    2 diseases from the University of Copenhagen DISEASES database for FBXO32:
    Muscular atrophy     Myopathy of critical illness

    3 Novoseek disease relationships for FBXO32 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atrophy 79.9 58 16507768 (4), 17478621 (2), 17992259 (2), 18599544 (2) (see all 29)
    hypertrophy 55.5 11 18235241 (2), 15550386 (1), 19117950 (1), 16916907 (1) (see all 6)
    aids 0 1 18583931 (1)

    Human Genome Epidemiology (HuGE) Navigator: FBXO32 (2 documents)

    Export disorders for FBXO32 gene to outside databases

    Publications
    for FBXO32 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO32 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with FBXO32)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ubiquitin ligases required for skeletal muscle atrophy. (PubMed id 11679633)1, 2, 3 Bodine S.C.... Glass D.J. (2001)
    2. Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1. (PubMed id 22249105)1, 2 Julie L.C.... Leibovitch S.A. (2012)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. (PubMed id 11717410)1, 3 Gomes M.D....Goldberg A.L. (2001)
    5. Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. (PubMed id 19117950)1, 9 Xie P....Li H. (2009)
    6. Expression of the muscle atrophy factor muscle atrophy F-box is suppressed by testosterone. (PubMed id 18599544)1, 9 Zhao W....Cardozo C.P. (2008)
    7. Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase. (PubMed id 15531760)2, 9 Tintignac L.A....Leibovitch S.A. (2005)
    8. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. (PubMed id 17992259)1, 9 Hanai J....Lecker S.H. (2007)
    9. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. (PubMed id 17478621)1, 9 Doucet M....Maltais F. (2007)
    10. Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. (PubMed id 16507768)1, 9 Leger B....Russell A.P. (2006)

    External Searches for FBXO32 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FBXO32 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114907 HGNC: 16731 AceView: FBXO32 Ensembl:ENSG00000156804 euGenes: HUgn114907
    ECgene: FBXO32 H-InvDB: FBXO32

    Other Databases showing FBXO32 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FBXO32 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO32 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FBXO32 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FBXO32 gene:
    Search GeneIP for patents involving FBXO32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FBXO32 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for FBXO32   OriGene shRNA RFP for FBXO32  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO32   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO32  
     OriGene Protein Over-expression Lysate for FBXO32   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FBXO32   OriGene 3'-UTR Clone for FBXO32  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO32   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO32  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXO32   OriGene Custom Protein Services for FBXO32  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO32
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO32
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO32
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO32
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO32
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO32
     GenScript Custom Purified and Recombinant Proteins Services for FBXO32 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO32
     GenScript Custom Assay Services for FBXO32 GenScript Custom Superior Antibodies Services for FBXO32
     GenScript Custom overexpressing Cell Line Services for FBXO32 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXO32 promoter
     Search Chromatin IP Primers for FBXO32
     RT2 qPCR Primer Assay in human, mouse, rat FBXO32
     Search GNC Networks for FBXO32
     SABiosciences PCR Arrays including human, mouse, rat FBXO32
     Search Tocris compounds for FBXO32
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FBXO32 antibodies
     FBXO32 proteins
     FBXO32 lysates
     Search for Antibodies for FBXO32 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FBXO32
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FBXO32 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FBXO32
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO32
     SwitchGear 3'UTR luciferase reporter plasmids for FBXO32
     SwitchGear Promoter luciferase reporter plasmids for FBXO32
     ThermoFisher Antibodies for FBXO32
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO32
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FBXO32 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4