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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO32 Gene

protein-coding   GIFtS: 53
GCID: GC08M124510

F-Box Protein 32

(Previous name: F-box only protein 32)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 321 2     atrogin-12
F-Box Only Protein 321 2     Atrogin-13
Muscle Atrophy F-Box Protein2 3     ATROGIN15
MAFbx2 3     FLJ324245
Fbx322     MAFBX5
Atrogin 12     

External Ids:    HGNC: 167311   Entrez Gene: 1149072   Ensembl: ENSG000001568047   OMIM: 6066045   UniProtKB: Q969P53   

Export aliases for FBXO32 gene to outside databases

Previous GC identifers: GC08M123657 GC08M124573 GC08M124184 GC08M124471 GC08M124584 GC08M119840


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO32 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle
atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a
potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript
variants encoding different isoforms. (provided by RefSeq, Jun 2011)

GeneCards Summary for FBXO32 Gene: 
FBXO32 (F-box protein 32) is a protein-coding gene. Diseases associated with FBXO32 include myopathy of critical illness, and acquired immunodeficiency syndrome. An important paralog of this gene is FBXO25.

UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and
binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1

Gene Wiki entry for FBXO32 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO32 gene promoter:
         FOXO1a   CUTL1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXO32 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

FBXO32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO32 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M124510:  view genomic region     (about GC identifiers)

Start:
124,510,127 bp from pter      End:
124,553,493 bp from pter
Size:
43,367 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5 (See protein sequence)
Recommended Name: F-box only protein 32  
Size: 355 amino acids; 41637 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1,
RBX1 and FBXO32
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus
Secondary accessions: A4KYM0
Alternative splicing: 2 isoforms:  Q969P5-1   Q969P5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO32: NX_Q969P5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969P5

  • FBXO32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (3 alternative transcripts): 
    NP_001229392.1  NP_478136.1  NP_680482.1  

    ENSEMBL proteins: 
     ENSP00000428205   ENSP00000390790  

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO32 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0030018Z disc IEA--

    FBXO32 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q969P5

    ProtoNet protein and cluster: Q969P5

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Similarity: Contains 1 F-box domain


    FBXO32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX32_HUMAN, Q969P5
    Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and
    binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18354498
         
    FBXO32 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fbxo32):
     muscle 

    FBXO32 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO32 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO32 
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    hsa-miR-548j hsa-miR-642a hsa-miR-938 hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFBXO32 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXO32 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Monoamine Transport
    Monoamine Transport
    2FoxO family signaling
    FoxO family signaling


    2 BioSystems Pathways for FBXO32
        Monoamine Transport
    FoxO family signaling


    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO32

    5 Interacting proteins for FBXO32 (Q969P52, 3) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003032, 3MINT-6613268 MINT-6613284 MINT-6613316 MINT-6613441 MINT-6613301 MINT-6613335 MINT-6613420 I2D: score=3 
    SKP1P632083I2D: score=3 
    EIF3AQ141523I2D: score=1 
    MLH1P406923I2D: score=1 
    MYOGP151733I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014894response to denervation involved in regulation of muscle adaptation ISS--
    GO:0016567protein ubiquitination IEA--

    FBXO32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FBXO32 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO32 (FBX32)

    3 Novoseek inferred chemical compound relationships for FBXO32 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 41.2 3 19533653 (1), 19927034 (1), 17418104 (1)
    dexamethasone 18.9 2 15550386 (1), 19631210 (1)
    glycogen 17.1 5 19533653 (1), 16916907 (1), 17478621 (1)

    Search CenterWatch for drugs/clinical trials and news about FBXO32 / FBX32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO32 gene (3 alternative transcripts): 
    NM_001242463.1  NM_058229.3  NM_148177.2  

    Unigene Cluster for FBXO32:

    F-box protein 32
    Hs.403933  [show with all ESTs]
    Unigene Representative Sequence: NM_058229
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517956(uc003yqp.2 uc003yqr.3 uc010mdk.3) ENST00000524000
    ENST00000287396 ENST00000443022 ENST00000521719 ENST00000520511
    miRNA
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    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO32 (see all 101):
    hsa-miR-548j hsa-miR-642a hsa-miR-938 hsa-miR-374a hsa-miR-30d hsa-miR-342-3p hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFBXO32 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO32
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO32

    Additional mRNA sequence: 

    AJ420108.1 AK023391.1 AK056986.1 AK096904.1 AK124390.1 AK125888.1 AY059629.1 BC022416.1 
    BC024030.2 BC100020.1 BC120963.1 BC120964.1 EF143260.1 

    9 DOTS entries:

    DT.95369675  DT.454988  DT.91663722  DT.100817561  DT.207029  DT.100817563  DT.100815255  DT.100817565 
    DT.121478817 

    24/265 AceView cDNA sequences (see all 265):

    AI276121 AI694613 BM763083 CA503406 BF439972 AI037983 AA233299 CF264867 
    BX103026 BM676248 AI358834 AI399801 AI091171 BQ045375 AY059629 BX096918 
    AI286347 AI289755 AI581780 BU689512 AW631249 BM665185 BQ772828 CK299060 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO32 expression in normal human tissues (normalized intensities)      FBXO32 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGACAT
    FBXO32 Expression
    About this image


    FBXO32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem MEL2, NCr-fac Progenitor
             sensory organ/nose/vomeronasal organ   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             deltoid muscle   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    Genevestigator expression for FBXO32

    SOURCE GeneReport for Unigene cluster: Hs.403933

    UniProtKB/Swiss-Prot: FBX32_HUMAN, Q969P5
    Tissue specificity: Specifically expressed in cardiac and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO32: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO32 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo321 , 5 F-box protein 321, 5 91.17(n)1
    96.62(a)1
      15 (24.43 cM)5
    677311  NM_026346.31  NP_080622.11 
     581758795 
    chicken
    (Gallus gallus)
    Aves FBXO321 F-box protein 32 84.04(n)
    92.68(a)
      420343  NM_001030956.1  NP_001026127.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO326
    Uncharacterized protein
    90(a)
    1 ↔ 1
    4(6740590-6773788)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564792 similar to F-box only protein 32 77.02(n)   393891  BC052112.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116581 CG11658 48.43(n)
    31.27(a)
      39319  NM_140241.2  NP_648498.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mfb-16
    Protein MFB-1
    21(a)
    1 → many
    I(8779737-8785415)


    ENSEMBL Gene Tree for FBXO32 (if available)
    TreeFam Gene Tree for FBXO32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO32 gene
    FBXO252  
    1 SIMAP similar gene for FBXO32 using alignment to 4 protein entries:     FBX32_HUMAN (see all proteins):
    FBXO25

    FBXO32 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/914 SNPs in FBXO32 are shown (see all 914)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70133751,2
    C,F--124509660(+) cactgC/Tacctg 3 -- ds500112Minor allele frequency- T:0.10NA WA CSA EA 375
    rs1453340171,2
    --124509750(+) AAAACA/CACACA 3 -- ds50010--------
    rs1479893011,2
    --124509775(+) AATTTC/GTGTCT 3 -- ds50010--------
    rs737059431,2
    C,F--124509806(+) GTGCCT/GTGCAC 3 -- ds50012Minor allele frequency- G:0.10WA 120
    rs1416286971,2
    --124510168(+) CAAAAG/TTTTTT 3 -- ut310--------
    rs22809151,2
    C,F,H--124510274(+) TCACAC/TAATAT 3 -- ut3119Minor allele frequency- T:0.16EA NA NS WA 3962
    rs1906355051,2
    --124510293(+) CATCTC/TTGCAT 3 -- ut310--------
    rs1827586461,2
    --124510342(+) ACCCCC/TTCTAA 3 -- ut310--------
    rs286676631,2
    --124510356(+) TTTTCA/CTTTAA 3 -- ut310--------
    rs749657491,2
    C,F--124510409(+) TATACG/ACCCAC 3 -- ut311Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for FBXO32 (124510127 - 124553493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FBXO32:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831450CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606604    OMIM disorders: --

    20/24 diseases for FBXO32 (see all 24):    About MalaCards
    myopathy of critical illness    acquired immunodeficiency syndrome    primary hyperparathyroidism    spinal cord injury
    duchenne muscular dystrophy    lymphopenia    hyperthyroidism    hyperparathyroidism
    uremia    myopathy    myositis    chronic obstructive pulmonary disease
    muscular atrophy    muscular dystrophy    lateral sclerosis    amyotrophic lateral sclerosis
    kidney disease    cystic fibrosis    myocardial infarction    ischemia

    2 diseases from the University of Copenhagen DISEASES database for FBXO32:
    Muscular atrophy     Myopathy of critical illness

    FBXO32 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for FBXO32 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atrophy 79.9 58 16507768 (4), 17478621 (2), 17992259 (2), 18599544 (2) (see all 29)
    hypertrophy 55.5 11 18235241 (2), 15550386 (1), 19117950 (1), 16916907 (1) (see all 6)
    aids 0 1 18583931 (1)

    Genetic Association Database (GAD): FBXO32
    Human Genome Epidemiology (HuGE) Navigator: FBXO32 (2 documents)

    Export disorders for FBXO32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO32 gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with FBXO32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ubiquitin ligases required for skeletal muscle atrophy. (PubMed id 11679633)1, 2, 3 Bodine S.C.... Glass D.J. (2001)
    2. Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1. (PubMed id 22249105)1, 2 Julie L.C.... Leibovitch S.A. (2012)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. (PubMed id 11717410)1, 3 Gomes M.D....Goldberg A.L. (2001)
    6. Atrogin-1/MAFbx enhances simulated ischemia/reperfusion-induced apoptosis in cardiomyocytes through degradation of MAPK phosphatase-1 and sustained JNK activation. (PubMed id 19117950)1, 9 Xie P....Li H. (2009)
    7. Expression of the muscle atrophy factor muscle atrophy F-box is suppressed by testosterone. (PubMed id 18599544)1, 9 Zhao W....Cardozo C.P. (2008)
    8. Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase. (PubMed id 15531760)2, 9 Tintignac L.A....Leibovitch S.A. (2005)
    9. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. (PubMed id 17992259)1, 9 Hanai J....Lecker S.H. (2007)
    10. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. (PubMed id 17478621)1, 9 Doucet M....Maltais F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114907 HGNC: 16731 AceView: FBXO32 Ensembl:ENSG00000156804 euGenes: HUgn114907
    ECgene: FBXO32 H-InvDB: FBXO32

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO32 gene:
    Search GeneIP for patents involving FBXO32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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