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Aliases for FBXO32 Gene

Aliases for FBXO32 Gene

  • F-Box Protein 32 2 3
  • MAFbx 3 4 6
  • Muscle Atrophy F-Box Protein 3 4
  • F-Box Only Protein 32 2 3
  • Atrogin-1 3 4
  • Atrogin 1 3
  • FLJ32424 6
  • ATROGIN1 6
  • Fbx32 3

External Ids for FBXO32 Gene

Summaries for FBXO32 Gene

Entrez Gene Summary for FBXO32 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

GeneCards Summary for FBXO32 Gene

FBXO32 (F-Box Protein 32) is a Protein Coding gene. Diseases associated with FBXO32 include myopathy of critical illness. Among its related pathways are FoxO signaling pathway and Monoamine Transport. An important paralog of this gene is FBXO25.

UniProtKB/Swiss-Prot for FBXO32 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Gene Wiki entry for FBXO32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO32 Gene

Genomics for FBXO32 Gene

Genomic Location for FBXO32 Gene

Start:
123,497,887 bp from pter
End:
123,541,253 bp from pter
Size:
43,367 bases
Orientation:
Minus strand

Genomic View for FBXO32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO32 Gene

Regulatory Elements for FBXO32 Gene

Transcription factor binding sites by QIAGEN in the FBXO32 gene promoter:

Proteins for FBXO32 Gene

  • Protein details for FBXO32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969P5-FBX32_HUMAN
    Recommended name:
    F-box only protein 32
    Protein Accession:
    Q969P5
    Secondary Accessions:
    • A4KYM0

    Protein attributes for FBXO32 Gene

    Size:
    355 amino acids
    Molecular mass:
    41637 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32

    Alternative splice isoforms for FBXO32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO32 Gene

Proteomics data for FBXO32 Gene at MOPED

Post-translational modifications for FBXO32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO32 Gene

No data available for DME Specific Peptides for FBXO32 Gene

Domains for FBXO32 Gene

Gene Families for FBXO32 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO32 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FBX32_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q969P5
genes like me logo Genes that share domains with FBXO32: view

Function for FBXO32 Gene

Molecular function for FBXO32 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Gene Ontology (GO) - Molecular Function for FBXO32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18354498
genes like me logo Genes that share ontologies with FBXO32: view

Phenotypes for FBXO32 Gene

MGI mutant phenotypes for FBXO32:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FBXO32: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO32 Gene

Localization for FBXO32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO32 Gene

Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO32 Gene COMPARTMENTS Subcellular localization image for FBXO32 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FBXO32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FBXO32: view

Pathways for FBXO32 Gene

genes like me logo Genes that share pathways with FBXO32: view

Pathways by source for FBXO32 Gene

2 BioSystems pathways for FBXO32 Gene
1 KEGG pathway for FBXO32 Gene

UniProtKB/Swiss-Prot Q969P5-FBX32_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014894 response to denervation involved in regulation of muscle adaptation ISS --
GO:0016567 protein ubiquitination IEA --
GO:0071549 cellular response to dexamethasone stimulus IEA --
genes like me logo Genes that share ontologies with FBXO32: view

Compounds for FBXO32 Gene

(3) Novoseek inferred chemical compound relationships for FBXO32 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 41.2 3
dexamethasone 18.9 2
glycogen 17.1 3
genes like me logo Genes that share compounds with FBXO32: view

Transcripts for FBXO32 Gene

Unigene Clusters for FBXO32 Gene

F-box protein 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO32 Gene

No ASD Table

Relevant External Links for FBXO32 Gene

GeneLoc Exon Structure for
FBXO32
ECgene alternative splicing isoforms for
FBXO32

Expression for FBXO32 Gene

mRNA expression in normal human tissues for FBXO32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO32 Gene

This gene is overexpressed in Muscle - Skeletal (17.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO32 Gene

SOURCE GeneReport for Unigene cluster for FBXO32 Gene Hs.403933

mRNA Expression by UniProt/SwissProt for FBXO32 Gene

Q969P5-FBX32_HUMAN
Tissue specificity: Specifically expressed in cardiac and skeletal muscle
genes like me logo Genes that share expressions with FBXO32: view

Orthologs for FBXO32 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO32 36
  • 99.34 (n)
  • 99.15 (a)
FBXO32 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO32 36
  • 93.62 (n)
  • 98.03 (a)
FBXO32 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO32 36
  • 93.99 (n)
  • 98.31 (a)
FBXO32 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo32 36
  • 91.17 (n)
  • 96.62 (a)
Fbxo32 16
Fbxo32 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO32 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO32 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo32 36
  • 90.95 (n)
  • 96.57 (a)
chicken
(Gallus gallus)
Aves FBXO32 36
  • 84.04 (n)
  • 92.68 (a)
FBXO32 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO32 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo32 36
  • 77.62 (n)
  • 84.42 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo32 36
  • 72.03 (n)
  • 76.27 (a)
fbxo32 37
  • 76 (a)
OneToOne
zgc56479 36
fruit fly
(Drosophila melanogaster)
Insecta CG11658 37
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mfb-1 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for FBXO32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO32 Gene

ENSEMBL:
Gene Tree for FBXO32 (if available)
TreeFam:
Gene Tree for FBXO32 (if available)

Paralogs for FBXO32 Gene

Paralogs for FBXO32 Gene

Selected SIMAP similar genes for FBXO32 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXO32: view

Variants for FBXO32 Gene

Sequence variations from dbSNP and Humsavar for FBXO32 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1717 -- 123,500,357(+) GACAT(C/G)TATTT utr-variant-3-prime
rs1043602 -- 123,498,874(-) TTTCA(A/C)AGACC utr-variant-3-prime
rs1048515 -- 123,502,529(-) GAGGA(A/C/T)TGCTT utr-variant-3-prime
rs1048593 -- 123,503,376(-) AAGTT(C/T)TGAAT reference, synonymous-codon
rs2280915 -- 123,498,034(+) TCACA(C/T)AATAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO32 Gene

Variant ID Type Subtype PubMed ID
nsv831450 CNV Gain 17160897

Relevant External Links for FBXO32 Gene

HapMap Linkage Disequilibrium report
FBXO32

Disorders for FBXO32 Gene

(2) University of Copenhagen DISEASES for FBXO32 Gene

(3) Novoseek inferred disease relationships for FBXO32 Gene

Disease -log(P) Hits PubMed IDs
atrophy 79.9 35
hypertrophy 55.5 7
aids 0 1

Relevant External Links for FBXO32

Genetic Association Database (GAD)
FBXO32
Human Genome Epidemiology (HuGE) Navigator
FBXO32
genes like me logo Genes that share disorders with FBXO32: view

No data available for UniProtKB/Swiss-Prot for FBXO32 Gene

Publications for FBXO32 Gene

  1. Identification of ubiquitin ligases required for skeletal muscle atrophy. (PMID: 11679633) Bodine S.C. … Glass D.J. (Science 2001) 2 3 4
  2. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. (PMID: 11717410) Gomes M.D. … Goldberg A.L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 49
  4. Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1. (PMID: 22249105) Julie L.C. … Leibovitch S.A. (FEBS Lett. 2012) 3 4
  5. Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase. (PMID: 15531760) Tintignac L.A. … Leibovitch S.A. (J. Biol. Chem. 2005) 4 23

Products for FBXO32 Gene

Sources for FBXO32 Gene

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