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FBXO31 Gene

protein-coding   GIFtS: 46
GCID: GC16M087367

F-Box Protein 31

(Previous name: F-box only protein 31)
  See FBXO31-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 311 2     Fbx312
FBX142 3 5     pp23862
F-Box Only Protein 311 2     Putative Breast Cancer Tumor-Suppressor2
FBXO142 5     SCF Ubiquitin Ligase Specificity Factor2
FBX313 5     

External Ids:    HGNC: 165101   Entrez Gene: 797912   Ensembl: ENSG000001032647   OMIM: 6091025   UniProtKB: Q5XUX03   

Export aliases for FBXO31 gene to outside databases

Previous GC identifers: GC00U991104 GC16M087145 GC16M085920 GC16M087362 GC16M073106 GC16M087365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO31 Gene:
This gene is a member of the F-box family. Members are classified into three classes according to the substrate
interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein,
classified into the last category because of the lack of a recognizable substrate binding domain, has been
proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for
ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite
growth and neuronal migration. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Sep 2013)

GeneCards Summary for FBXO31 Gene:
FBXO31 (F-box protein 31) is a protein-coding gene. Diseases associated with FBXO31 include mast cell neoplasm, and breast cancer. GO annotations related to this gene include cyclin binding.

UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest
following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and
degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor

Gene Wiki entry for FBXO31 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO31 gene promoter:
         Egr-3   Spz1   HOXA3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-4alpha1   AREB6   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO31 promoter sequence
   Search Chromatin IP Primers for FBXO31

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24

FBXO31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO31 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M087367:  view genomic region     (about GC identifiers)

Start:
87,360,593 bp from pter      End:
87,425,748 bp from pter
Size:
65,156 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0 (See protein sequence)
Recommended Name: F-box only protein 31  
Size: 539 amino acids; 60664 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex
Developmental stage: Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level)
Sequence caution: Sequence=AAH12748.1; Type=Erroneous initiation; Sequence=AAL55855.1; Type=Frameshift;
Positions=496; Sequence=CAB55929.2; Type=Erroneous initiation;
Secondary accessions: Q5K680 Q8WYV1 Q96D73 Q9UFV4
Alternative splicing: 2 isoforms:  Q5XUX0-1   Q5XUX0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO31: NX_Q5XUX0

Explore proteomics data for FBXO31 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO31 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269612.1  NP_079011.3  

    ENSEMBL proteins: 
     ENSP00000310841   ENSP00000455772   ENSP00000457578  

    FBXO31 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO31

     
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    antibodies-online proteins for FBXO31 (5 products) 

     
    antibodies-online peptides for FBXO31

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    antibodies-online antibodies for FBXO31 (35 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    2 InterPro protein domains:
     IPR001810 F-box_dom
     IPR026941 FBXO31

    Graphical View of Domain Structure for InterPro Entry Q5XUX0

    ProtoNet protein and cluster: Q5XUX0

    UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0
    Similarity: Belongs to the FBXO31 family
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO31           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX31_HUMAN, Q5XUX0
    Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest
    following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and
    degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor
    Induction: By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or
    addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030332cyclin binding IPI19412162
         
    Find genes that share ontologies with FBXO31           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO31:
     Upregulation of NF-kappaB path 

         1 MGI phenotypic allele for Fbxo31 (no phenotypes)

    Find genes that share phenotypes with FBXO31           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO31
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    miRNA
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    miRTarBase miRNAs that target FBXO31:
    hsa-mir-320a (MIRT044521), hsa-mir-192-5p (MIRT026239), hsa-mir-92b-3p (MIRT040530), hsa-mir-18a-3p (MIRT040924), hsa-mir-17-5p (MIRT004529)

    Block miRNA regulation of human, mouse, rat FBXO31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO31 (see all 15):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-3617 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO31 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO31

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    GenScript: all cDNA clones in your preferred vector: FBXO31 (NM_024735)
    Sino Biological Human cDNA Clone for FBXO31
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO31

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO31


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019005SCF ubiquitin ligase complex IDA19412162

    Find genes that share ontologies with FBXO31           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO31: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO31

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for FBXO31 (Q5XUX03 ENSP000003108414) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    RBX1P628773, ENSP000002162254I2D: score=2 STRING: ENSP00000216225
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    CCND1P243853, ENSP000002275074I2D: score=1 STRING: ENSP00000227507
    BTRCENSP000003592064STRING: ENSP00000359206
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006974cellular response to DNA damage stimulus IDA19412162
    GO:0008054cyclin catabolic process IMP19412162
    GO:0016567protein ubiquitination IEA--
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA19412162
    GO:0031571mitotic G1 DNA damage checkpoint IMP19412162

    Find genes that share ontologies with FBXO31           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO31 (FBX31)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO31 gene (2 alternative transcripts): 
    NM_001282683.1  NM_024735.4  

    Unigene Cluster for FBXO31:

    F-box protein 31
    Hs.567582  [show with all ESTs]
    Unigene Representative Sequence: AF318348
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311635(uc002fjv.3 uc002fjw.3 uc010vot.2) ENST00000565593
    ENST00000563113 ENST00000561664 ENST00000569412 ENST00000563956 ENST00000567622

    miRNA
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    Block miRNA regulation of human, mouse, rat FBXO31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO31 (see all 15):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-3617 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO31 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO31
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXO31
      QuantiFast Probe-based Assays in human, mouse, rat FBXO31

    Additional mRNA sequence: 

    AF318348.1 AF428140.1 AK311122.1 AL117444.1 AY736035.1 BC012748.1 NR_024568.1 

    11 DOTS entries:

    DT.95277997  DT.116196  DT.99985379  DT.40211501  DT.92432396  DT.100699556  DT.120672925  DT.95087735 
    DT.95266578  DT.101970786  DT.92432392 

    Selected AceView cDNA sequences (see all 257):

    BM726429 T33152 BE351048 BG760339 CB243482 BE552242 AI087321 BU741199 
    BI254086 BM674169 AI240427 BP334339 AA854791 CD369955 AA931611 BU541895 
    BM726927 AI187995 BX280656 BU541763 AI298379 BF110519 BQ446155 BC002985 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FBXO31 Expression
    About this image

    FBXO31 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO31 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567582

    UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0
    Tissue specificity: Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO31: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO31 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo311 , 5 F-box protein 311, 5 86.26(n)1
    91.72(a)1
      8 (70.65 cM)5
    764541  NM_133765.41  NP_598526.31 
     1215494405 
    chicken
    (Gallus gallus)
    Aves LOC1008574451 F-box only protein 31-like 78.29(n)
    84.26(a)
      100857445  XM_003643183.2  XP_003643231.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO316
    F-box protein 31
    72(a)
    1 ↔ 1
    GL343957.1(43524-66581)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo311 F-box protein 31 68.08(n)
    73.55(a)
      779980  NM_001079057.1  NP_001072525.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-147k9.71 si:ch211-147k9.7 69.71(n)
    71.98(a)
      555190  XM_005170700.1  XP_005170757.1 


    ENSEMBL Gene Tree for FBXO31 (if available)
    TreeFam Gene Tree for FBXO31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO31 (see all 1565)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488495901,2
    --87362451(+) TAATGC/TGCTTG 2 -- int10--------
    rs1425781561,2
    C--87362497(+) GAAACA/GGTTTT 2 -- int10--------
    rs740387251,2
    C--87362524(+) CCCTTA/TGGCCT 2 -- int16Minor allele frequency- T:0.13WA CSA NA EA 362
    rs1149908131,2
    F--87362525(+) CCTTAG/CGCCTC 2 -- int11Minor allele frequency- C:0.01WA 118
    rs1829933001,2
    --87362641(+) TGAGGC/TGCGCA 2 -- int10--------
    rs1423923371,2
    C--87362746(+) TGGCT-/GGTGCG 2 -- int10--------
    rs2007945941,2
    --87362829(+) AGAGA-/CCCCCG 2 -- int10--------
    rs1460693471,2
    C--87362951(+) GATCTA/GAGATT 2 -- ut31 nc-transcript-variant0--------
    rs1869635071,2
    --87363009(+) AAAGGA/GCACGC 2 -- ut31 nc-transcript-variant0--------
    rs1389393761,2
    C--87363147(+) GGCCAC/TAGTCA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for FBXO31 (87360593 - 87425748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FBXO31 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658266CNV Deletion23128226
    esv2714922CNV Deletion23290073
    dgv2950n71CNV Loss21882294
    nsv907155CNV Loss21882294
    nsv510694CNV Loss20534489
    nsv907156CNV Loss21882294
    nsv907153CNV Loss21882294
    nsv833320CNV Gain17160897
    nsv907154CNV Gain21882294
    nsv907157CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609102    OMIM disorders: --

    2 diseases for FBXO31:    
    About MalaCards
    mast cell neoplasm    breast cancer

    1 disease from the University of Copenhagen DISEASES database for FBXO31:
    Mast cell neoplasm

    Find genes that share disorders with FBXO31           About GenesLikeMe


    Export disorders for FBXO31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO31 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with FBXO31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. (PubMed id 19412162)1, 2 Santra M.K.... Green M.R. (Nature 2009)
    2. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. (PubMed id 16357137)1, 2 Kumar R.... Callen D.F. (Cancer Res. 2005)
    3. Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (Genes Dev. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The centrosomal E3 ubiquitin ligase FBXO31-SCF regulates neuronal morphogenesis and migration. (PubMed id 23469015)1 Vadhvani M....StegmA1ller J. (PLoS ONE 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. (PubMed id 24085301)1 Yumimoto K....Nakayama K.I. (J. Biol. Chem. 2013)
    8. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1  ....Sullivan P.F. (Mol. Psychiatry 2013)
    9. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. (PubMed id 22632973)1 Chan C.H....Lin H.K. (Cell 2012)
    10. FBXO31 determines poor prognosis in esophageal squamous cell carcinoma. (PubMed id 21537837)1 Kogo R....Mori M. (Int. J. Oncol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79791 HGNC: 16510 AceView: FBXO31 Ensembl:ENSG00000103264 euGenes: HUgn79791
    ECgene: FBXO31 H-InvDB: FBXO31

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO31 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FBXO31 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO31 gene:
    Search GeneIP for patents involving FBXO31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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