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Aliases for FBXO31 Gene

Aliases for FBXO31 Gene

  • F-Box Protein 31 2 3
  • Fbx31 3 4 6
  • FBX14 3 4 6
  • F-Box Only Protein 31 2 3
  • FBXO14 3 6
  • SCF Ubiquitin Ligase Specificity Factor 3
  • Putative Breast Cancer Tumor-Suppressor 3
  • Pp2386 3
  • MRT45 3

External Ids for FBXO31 Gene

Previous GeneCards Identifiers for FBXO31 Gene

  • GC00U991104
  • GC16M087145
  • GC16M085920
  • GC16M087362
  • GC16M073106
  • GC16M087365
  • GC16M087367

Summaries for FBXO31 Gene

Entrez Gene Summary for FBXO31 Gene

  • This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for FBXO31 Gene

FBXO31 (F-Box Protein 31) is a Protein Coding gene. Diseases associated with FBXO31 include mental retardation, autosomal recessive 45 and autosomal recessive non-syndromic intellectual disability. GO annotations related to this gene include cyclin binding.

UniProtKB/Swiss-Prot for FBXO31 Gene

  • Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Gene Wiki entry for FBXO31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO31 Gene

Genomics for FBXO31 Gene

Regulatory Elements for FBXO31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO31 Gene

87,326,987 bp from pter
87,392,142 bp from pter
65,156 bases
Minus strand

Genomic View for FBXO31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO31 Gene

Proteins for FBXO31 Gene

  • Protein details for FBXO31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 31
    Protein Accession:
    Secondary Accessions:
    • Q5K680
    • Q8WYV1
    • Q96D73
    • Q9UFV4

    Protein attributes for FBXO31 Gene

    539 amino acids
    Molecular mass:
    60664 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
    • Sequence=AAH12748.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL55855.1; Type=Frameshift; Positions=496; Evidence={ECO:0000305}; Sequence=CAB55929.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO31 Gene


neXtProt entry for FBXO31 Gene

Proteomics data for FBXO31 Gene at MOPED

Post-translational modifications for FBXO31 Gene

  • Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO31 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXO31

No data available for DME Specific Peptides for FBXO31 Gene

Domains for FBXO31 Gene

Gene Families for FBXO31 Gene

  • FBXO :F-boxes / "other"

Protein Domains for FBXO31 Gene


Suggested Antigen Peptide Sequences for FBXO31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5XUX0
  • Contains 1 F-box domain.
  • Belongs to the FBXO31 family.
genes like me logo Genes that share domains with FBXO31: view

Function for FBXO31 Gene

Molecular function for FBXO31 Gene

UniProtKB/Swiss-Prot Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
UniProtKB/Swiss-Prot Induction:
By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil.

Gene Ontology (GO) - Molecular Function for FBXO31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030332 cyclin binding IPI 19412162
genes like me logo Genes that share ontologies with FBXO31: view

Phenotypes for FBXO31 Gene

GenomeRNAi human phenotypes for FBXO31:
genes like me logo Genes that share phenotypes with FBXO31: view

Animal Model Products

miRNA for FBXO31 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO31 Gene

Localization for FBXO31 Gene

Subcellular locations from

Jensen Localization Image for FBXO31 Gene COMPARTMENTS Subcellular localization image for FBXO31 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBXO31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 19412162
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with FBXO31: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO31 Gene

Pathways for FBXO31 Gene

SuperPathways for FBXO31 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q5XUX0-FBX31_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 19412162
GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation IMP 19412162
GO:0016567 protein ubiquitination IEA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 19412162
GO:0031571 mitotic G1 DNA damage checkpoint IMP 19412162
genes like me logo Genes that share ontologies with FBXO31: view

No data available for Pathways by source for FBXO31 Gene

Transcripts for FBXO31 Gene

Unigene Clusters for FBXO31 Gene

F-box protein 31:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO31

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO31 Gene

No ASD Table

Relevant External Links for FBXO31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO31 Gene

mRNA expression in normal human tissues for FBXO31 Gene

Protein differential expression in normal tissues for FBXO31 Gene

This gene is overexpressed in Adipocyte (49.5) and Frontal cortex (19.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO31 Gene

SOURCE GeneReport for Unigene cluster for FBXO31 Gene Hs.567582

mRNA Expression by UniProt/SwissProt for FBXO31 Gene

Tissue specificity: Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
genes like me logo Genes that share expressions with FBXO31: view

Expression partners for FBXO31 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FBXO31 Gene

Orthologs for FBXO31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO31 35
  • 86.75 (n)
  • 89.62 (a)
FBXO31 36
  • 81 (a)
(Canis familiaris)
Mammalia FBXO31 35
  • 84.98 (n)
  • 88.21 (a)
FBXO31 36
  • 82 (a)
(Mus musculus)
Mammalia Fbxo31 35
  • 86.26 (n)
  • 91.72 (a)
Fbxo31 16
Fbxo31 36
  • 91 (a)
(Pan troglodytes)
Mammalia FBXO31 35
  • 99.38 (n)
  • 99.81 (a)
FBXO31 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Fbxo31 35
  • 86.19 (n)
  • 91.12 (a)
(Monodelphis domestica)
Mammalia FBXO31 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO31 36
  • 86 (a)
(Gallus gallus)
Aves LOC100857445 35
  • 78.29 (n)
  • 84.26 (a)
-- 36
  • 73 (a)
-- 36
  • 79 (a)
-- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia FBXO31 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo31 35
  • 68.08 (n)
  • 73.55 (a)
(Danio rerio)
Actinopterygii si:ch211-147k9.7 35
  • 69.71 (n)
  • 71.98 (a)
FBXO31 36
  • 65 (a)
Species with no ortholog for FBXO31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO31 Gene

Gene Tree for FBXO31 (if available)
Gene Tree for FBXO31 (if available)

Paralogs for FBXO31 Gene

No data available for Paralogs for FBXO31 Gene

Variants for FBXO31 Gene

Sequence variations from dbSNP and Humsavar for FBXO31 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs42857 -- 87,357,333(-) aaaaa(A/T)aaaaa intron-variant
rs189703 -- 87,332,746(-) GCTCC(C/T)GGAGG intron-variant
rs190434 -- 87,349,709(-) ttttt(C/G)agatg intron-variant
rs194198 -- 87,349,697(-) agtct(C/T)gctct intron-variant
rs254300 -- 87,349,515(-) ccagg(A/C)tggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO31 Gene

Variant ID Type Subtype PubMed ID
nsv907153 CNV Loss 21882294
nsv510694 CNV Loss 20534489
nsv907154 CNV Gain 21882294
nsv907155 CNV Loss 21882294
nsv907156 CNV Loss 21882294
nsv907157 CNV Gain 21882294
nsv833320 CNV Gain 17160897
nsv428330 CNV Gain 18775914
esv2714922 CNV Deletion 23290073
dgv499n67 CNV Gain 20364138
dgv2950n71 CNV Loss 21882294
esv2658266 CNV Deletion 23128226

Relevant External Links for FBXO31 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO31 Gene

Disorders for FBXO31 Gene


  • Mental retardation, autosomal recessive 45 (MRT45) [MIM:615979]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT45 manifestations include mild to moderate intellectual disability and dysmorphic features, including coarse facies, broad nasal bridge, fleshy nares, and thick, prominent lips. {ECO:0000269 PubMed:24623383}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FBXO31 Gene

genes like me logo Genes that share disorders with FBXO31: view

No data available for OMIM , Novoseek inferred disease relationships , Genatlas and External Links for FBXO31 Gene

Publications for FBXO31 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4
  3. F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. (PMID: 19412162) Santra M.K. … Green M.R. (Nature 2009) 3 4
  4. Truncation of the E3 ubiquitin ligase component FBXO31 causes non- syndromic autosomal recessive intellectual disability in a Pakistani family. (PMID: 24623383) Mir A. … Vincent J.B. (Hum. Genet. 2014) 3 4
  5. FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. (PMID: 16357137) Kumar R. … Callen D.F. (Cancer Res. 2005) 3 4

Products for FBXO31 Gene

Sources for FBXO31 Gene

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