FBXO31 Gene
protein-coding GIFtS: 48
GCID: GC16M087362
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F-box protein 31(Previous name: F-box only protein 31 )
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Aliases for FBXO31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| F-Box Protein 311 2 | | FBX313 5 | | FBX141 2 3 5 | | MGC154191 | | FBXO141 2 5 | | Pp23861 | | Fbx311 2 | | Putative Breast Cancer Tumor-Suppressor2 | | F-Box Only Protein 311 2 | | SCF Ubiquitin Ligase Specificity Factor2 |
| External Ids: | HGNC: 165101 | Entrez Gene: 797912 | Ensembl: ENSG000001032647 | OMIM: 6091025 | UniProtKB: Q5XUX03 |
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| | ORGUL members: | |
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| NONCODE:n407074 | |
Export aliases for FBXO31 gene to outside databasesPrevious GC identifers: GC00U991104 GC16M087145 GC16M085920 GC16M073106
Summaries for FBXO31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for FBXO31: Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrestfollowing DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination anddegradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor Gene Wiki entry for FBXO31
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Genomic Views for FBXO31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO31 gene promoter: Egr-3 Spz1 HOXA3 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 HNF-4alpha1 AREB6 Msx-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO31
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO31 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.2 Ensembl cytogenetic band: 16q24.2 HGNC cytogenetic band: 16q24FBXO31 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M087362: view genomic region
(about GC identifiers)
Start:
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87,362,942 bp from pter |
End:
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87,425,748 bp from pter |
Size:
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62,807 bases |
Orientation:
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minus strand |
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Proteins for FBXO31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0 (See
protein sequence)Recommended Name: F-box only protein 31 Size: 539 amino acids; 60664 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex
Developmental stage: Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level)
Sequence caution: Sequence=AAH12748.1; Type=Erroneous initiation; Sequence=AAL55855.1; Type=Frameshift; Positions=496;Sequence=CAB55929.2; Type=Erroneous initiation;
Secondary accessions: Q5K680 Q8WYV1 Q96D73 Q9UFV4Alternative splicing: 2 isoforms: Q5XUX0-1 Q5XUX0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBXO31: NX_Q5XUX0
Post-translational modifications:
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5XUX0 FBXO31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079011.3 ENSEMBL proteins: ENSP00000310841 ENSP00000455772 ENSP00000457578 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019005 | SCF ubiquitin ligase complex |
IDA | 19412162 |
FBXO31 for ontologies About GeneDecksing
FBXO31 Antibody Products: Assay Products for FBXO31: |
Protein
Domains / Families for FBXO31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO31 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5XUX0ProtoNet protein and cluster: Q5XUX0 UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0Similarity: Belongs to the FBXO31 familySimilarity: Contains 1 F-box domain |
Function for FBXO31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrestfollowing DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination anddegradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressorInduction: By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition ofthe chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO31 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXO31 (NM_024735) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO31  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO31 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
FBXO31 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FBXO31:
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Pathways & Interactions for FBXO31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO31
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
 5/24 Interacting proteins for FBXO31 (Q5XUX03 ENSP000003108414) via UniProtKB, MINT, STRING, and/or I2D (see all 24) About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
FBXO31 for ontologies About GeneDecksing
|
Drugs & Compounds for FBXO31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FBXO31 Search CenterWatch for drugs/clinical trials and news about FBXO31 / FBX31 
|
Transcripts for FBXO31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FBXO31 gene: NM_024735.3 Unigene Cluster for FBXO31: F-box protein 31 Hs.567582 [show with all ESTs]Unigene Representative Sequence: AF3183487 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000311635(uc002fjv.3 uc002fjw.3 uc010vot.2) ENST00000565593 ENST00000563113 ENST00000561664 ENST00000569412 ENST00000563956 ENST00000567622
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO31 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO31 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXO31 (NM_024735) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO31  |
Additional cDNA sequence: AF318348.1 AF428140.1 AK311122.1 AL117444.1 AY736035.1 BC012748.1 NR_024568.1 12 DOTS entries: DT.95277997 DT.116196 DT.99985379 DT.40211501 DT.92432396 DT.100699556 DT.120672925 DT.95087735 DT.95266578 DT.101970786 DT.100704332 DT.92432392 24/257 AceView cDNA sequences (see all 257): AA631197 CD369955 BG760339 BC002985 BE552242 AI240427 AI419213 BM726927 BM726429 AI861895 BF110519 BU541895 AI202075 BE351048 CB216612 BF845404 AI741611 BX348402 AI378962 BM467749 AA854791 AA931611 CB243482 BM674169 GeneLoc Exon Structure
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Expression for FBXO31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO31 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See FBXO31 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXO31
SOURCE GeneReport for Unigene cluster: Hs.567582 UniProtKB/Swiss-Prot: FBX31_HUMAN, Q5XUX0Tissue specificity: Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO31:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO31 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO31 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO31 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO31 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO31 |
Orthologs for FBXO31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FBXO31 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for FBXO31 (if available) TreeFam Gene Tree for FBXO31 (if available)  |
Paralogs for FBXO31 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for FBXO31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for FBXO31 (87362942 - 87425748 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FBXO31 1 CNV: 4970  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO31 |
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Disorders
/ Diseases for FBXO31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXO31 for disorders About GeneDecksing
OMIM gene information: 609102
OMIM disorders: --
4 diseases for FBXO31: About MalaCardsbreast cancer mast cell neoplasm esophagitis carcinoma 1 disease from the University of Copenhagen DISEASES database for FBXO31:Mast cell neoplasm Export disorders for FBXO31 gene to outside databases
|
Publications for FBXO31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO31 gene, integrated from 9 sources (see all 18): (articles sorted by number of sources associating them with FBXO31) | |  | Utopia: connect your pdf to the dynamic world of online information |
- F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. (PubMed id 19412162)1, 2 Santra M.K.... Green M.R. (2009)
- FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex. (PubMed id 16357137)1, 2 Kumar R.... Callen D.F. (2005)
- Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1, 2 Jin J....Harper J.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Skp2-SCF E3 ligase regulates Akt ubiquitination, g lycolysis, herceptin sensitivity, and tumorigenesis. (PubMed id 22632973)1 Chan C.H....Lin H.K. (2012)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- FBXO31 determines poor prognosis in esophageal squamo us cell carcinoma. (PubMed id 21537837)1 Kogo R....Mori M. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1 Rivadeneira F....Uitterlinden A.G. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
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External Searches for FBXO31 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FBXO31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXO31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for FBXO31 gene: Search GeneIP for patents involving FBXO31
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FBXO31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for FBXO31 | | OriGene Custom Protein Services for FBXO31 | | OriGene Custom Immunoassay Development | | |
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 | | FBXO31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO31 |
|  |  |  | | | ThermoFisher Antibodies for FBXO31 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO31 |
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