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FBXO30 Gene(Protein Coding)

F-Box Protein 30

GCID:
GC06M145795
GIFtS:
47
Genes Participants
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Aliases for FBXO30 Gene

Aliases for FBXO30 Gene

  • F-Box Protein 30 2 3 5
  • F-Box Only Protein, Helicase, 18 2 3
  • Fbx30 3 4
  • F-Box Only Protein 30 3
  • F-Box Domain Protein 3

External Ids for FBXO30 Gene

Previous GeneCards Identifiers for FBXO30 Gene

  • GC06M145742
  • GC06M145966
  • GC06M146099
  • GC06M146160
  • GC06M143682

Summaries for FBXO30 Gene

Entrez Gene Summary for FBXO30 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO30 Gene

FBXO30 (F-Box Protein 30) is a Protein Coding gene. Diseases associated with FBXO30 include Nasopharyngeal Carcinoma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXO40.

UniProtKB/Swiss-Prot for FBXO30 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO30 Gene

Genomics for FBXO30 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO30 Gene

Enhancers for FBXO30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G146289 1.4 FANTOM5 Ensembl ENCODE 8.9 -475.7 -475695 1.3 ATF1 GTF2E2 JUN ETV1 ZNF175 MAX FOSL1 GATA2 ZNF366 FOSL2 FBXO30 ENSG00000270638 RAB32 RNA5SP222 GC06P146172
GH06G145846 0.6 ENCODE 12.7 -30.5 -30514 0.2 MAFG BACH1 ZNF316 PBX2 NFE2L1 NFE2 MAFK EMSY NFE2L2 FBXO30 LOC100507557 GC06P145831 GC06P145856
GH06G145845 0.6 ENCODE 12.7 -30.3 -30334 0.2 PKNOX1 MAFG BACH1 ZNF316 PBX2 NFE2L1 NFE2 MAFK EMSY NFE2L2 FBXO30 LOC100507557 GC06P145856 GC06P145831
GH06G145890 0.6 ENCODE 11.1 -76.8 -76792 1.4 PKNOX1 FOXA2 TEAD1 BHLHE40 CEBPB CEBPA HNF4G FOS HNF4A LOC100507557 FBXO30 GC06M145895 GC06P145874
GH06G145842 0.2 ENCODE 11.7 -27.6 -27581 0.6 FBXO30 LOC100507557 GC06P145831 GC06P145856
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO30 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000204591 586 3601 PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766

Transcription factor binding sites by QIAGEN in the FBXO30 gene promoter:

Genomic Location for FBXO30 Gene

Chromosome:
6
Start:
145,793,502 bp from pter
End:
145,814,786 bp from pter
Size:
21,285 bases
Orientation:
Minus strand

Genomic View for FBXO30 Gene

Genes around FBXO30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO30 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO30 Gene

Proteins for FBXO30 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBXO30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB52-FBX30_HUMAN
    Recommended name:
    F-box only protein 30
    Protein Accession:
    Q8TB52
    Secondary Accessions:
    • Q9BXZ7

    Protein attributes for FBXO30 Gene

    Size:
    745 amino acids
    Molecular mass:
    82304 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1 (By similarity).
    SequenceCaution:
    • Sequence=AAK30299.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK30299.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBXO30 Gene

neXtProt entry for FBXO30 Gene

Protein Expression for FBXO30 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO30 Gene

Other Protein References for FBXO30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO30 Gene

Domains & Families for FBXO30 Gene

Gene Families for FBXO30 Gene

HGNC:

Protein Domains for FBXO30 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO30: view

No data available for UniProtKB/Swiss-Prot for FBXO30 Gene

Function for FBXO30 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO30 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

Gene Ontology (GO) - Molecular Function for FBXO30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with FBXO30: view
genes like me logo Genes that share phenotypes with FBXO30: view

Animal Model Products

CRISPR Products

miRNA for FBXO30 Gene

miRTarBase miRNAs that target FBXO30

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO30 Gene

Localization for FBXO30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO30 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBXO30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO30: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO30 Gene

Pathways & Interactions for FBXO30 Gene

genes like me logo Genes that share pathways with FBXO30: view

UniProtKB/Swiss-Prot Q8TB52-FBX30_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO30: view

No data available for SIGNOR curated interactions for FBXO30 Gene

Drugs & Compounds for FBXO30 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FBXO30 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO30 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(97) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO30 Gene

F-box protein 30:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO30 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: - -
SP2:

Relevant External Links for FBXO30 Gene

GeneLoc Exon Structure for
FBXO30
ECgene alternative splicing isoforms for
FBXO30

Expression for FBXO30 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO30 Gene

mRNA expression in normal human tissues for FBXO30 Gene
mRNA expression by GTEx for FBXO30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO30 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.1).

Protein differential expression in normal tissues from HIPED for FBXO30 Gene

This gene is overexpressed in Testis (14.1), Colon (12.4), Rectum (9.8), Gallbladder (7.9), Placenta (6.6), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO30 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO30 Gene:

FBXO30

SOURCE GeneReport for Unigene cluster for FBXO30 Gene:

Hs.421095
genes like me logo Genes that share expression patterns with FBXO30: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO30 Gene

Orthologs for FBXO30 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO30 34 35
  • 99.64 (n)
dog
(Canis familiaris)
 Mammalia FBXO30 34 35
  • 92.51 (n)
cow
(Bos Taurus)
 Mammalia FBXO30 34 35
  • 90.84 (n)
mouse
(Mus musculus)
 Mammalia Fbxo30 34 16 35
  • 88.68 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo30 34
  • 88.08 (n)
oppossum
(Monodelphis domestica)
 Mammalia FBXO30 35
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FBXO30 35
  • 79 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FBXO30 34 35
  • 75.89 (n)
lizard
(Anolis carolinensis)
 Reptilia FBXO30 35
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo30 34
  • 69.47 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14365 34
zebrafish
(Danio rerio)
 Actinopterygii fbxo30a 34 35
  • 62.69 (n)
zgc63656 34
Species where no ortholog for FBXO30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO30 Gene

ENSEMBL:
Gene Tree for FBXO30 (if available)
TreeFam:
Gene Tree for FBXO30 (if available)

Paralogs for FBXO30 Gene

Paralogs for FBXO30 Gene

(1) SIMAP similar genes for FBXO30 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FBXO30: view

Variants for FBXO30 Gene

Sequence variations from dbSNP and Humsavar for FBXO30 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036072 A colorectal cancer sample
rs1000056269 -- 145,839,176(+) ACATT(A/C)TAGAG intron-variant
rs1000176436 -- 145,806,660(+) TTTAT(A/G)TACTA intron-variant
rs1000188477 -- 145,824,909(+) ATTGC(A/G)TATTT intron-variant
rs1000221444 -- 145,818,541(+) TAAGG(-/T)TTTTT intron-variant

Variation tolerance for FBXO30 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO30 Gene

Disorders for FBXO30 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO30 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • nasopharynx carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO30
genes like me logo Genes that share disorders with FBXO30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO30 Gene

Publications for FBXO30 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. (PMID: 26087183) Tian X. … Jiang Y. (Oncotarget 2015) 3 64

Products for FBXO30 Gene

Sources for FBXO30 Gene

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