FBXO30 Gene
protein-coding GIFtS : 47
GCID: GC06 M146160
F-box protein 30 (Previous names: F-box only protein, helicase, 18 )
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Aliasesfor FBXO30 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases F-Box Protein 30 1 2 MGC216741 Fbx301 2 F-Box Domain Protein2 F-Box Only Protein, Helicase, 181 2 F-Box Only Protein 302 FBX303 5
Export aliases for FBXO30 gene to outside databases Previous GC identifers: GC06M145742 GC06M145966 GC06M146099 GC06M143682
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Summariesfor FBXO30 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FBXO30 : This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
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Genomic Viewsfor FBXO30 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO30 gene promoter: FOXO3 Nkx2-5 NF-kappaB FOXO3b AREB6 c-Rel NF-kappaB2 Sox9 FOXO3a NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for FBXO30 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FBXO30
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q24 Ensembl cytogenetic band: 6q24.3 HGNC cytogenetic band: 6q24 FBXO30 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M146160: view genomic region
(about GC identifiers )
Start:
146,119,271 bp from pter
End:
146,135,921 bp from pter
Size:
16,651 bases
Orientation:
minus strand
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Proteinsfor FBXO30 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52 (See
protein sequence )Recommended Name: F-box only protein 30 Size : 745 amino acids; 82304 Da
Subunit : Directly interacts with SKP1 and CUL1 (By similarity)
Sequence caution : Sequence=AAK30299.1; Type=Erroneous initiation; Sequence=AAK30299.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
1 PDB 3D structure from and Proteopedia for FBXO30 :2YRE (3D)
 
Secondary accessions : Q9BXZ7Explore the universe of human proteins at neXtProt for FBXO30: NX_Q8TB52 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TB52 FBXO30 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_115521.3 ENSEMBL proteins: ENSP00000237281 Human Recombinant Protein Products: FBXO30 Antibody Products: Assay Products for FBXO30:
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Protein
Domains / Familiesfor FBXO30 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FBXO30 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TB52 ProtoNet protein and cluster: Q8TB52
UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52 Similarity : Contains 1 F-box domainSimilarity : Contains 1 TRAF-type zinc finger
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Functionfor FBXO30 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO30 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO30 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FBXO30 (NM_032145 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO30 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO30
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO30
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004842 ubiquitin-protein ligase activity
IEA -- GO:0008270 zinc ion binding
IEA --
FBXO30 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for FBXO30 :
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Pathways & Interactionsfor FBXO30 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO30 STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)5/18 Interacting proteins for FBXO30 (Q8TB52 3 ENSP00000237281 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 18 )About this table
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Drugs & Compoundsfor FBXO30 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FBXO30 Search CenterWatch for drugs/clinical trials and news about FBXO30 / FBX30
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Transcriptsfor FBXO30 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FBXO30 gene: NM_032145.4 Unigene Cluster for FBXO30:
F-box protein 30 Hs.421095 [show with all ESTs ] Unigene Representative Sequence: NM_032145 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000237281 (uc003qla.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO30 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO30 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FBXO30 (NM_032145 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO30 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO30
Additional cDNA sequence: AF248640.1 AK055919.1 AK123026.1 AK124138.1 AK313613.1 BC024326.1
5 DOTS entries : DT.97763315 DT.441895
DT.100812915 DT.100812916 DT.95081720 24/97 AceView cDNA sequences (see all 97 ):
BE222001 AA282520 AI689778 CF528645 BC024326 AK123026 BQ937523 BG107447 AA120797 AL602397 BQ008946 BQ437745 AA649164 AI911351 AI291414 AK124138 R36818 BE466016 AW073863 AK055919 BF970337 AW149932 NM_032145 AI160733 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO30 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 SP1 :   -   -         SP2 :            
ECgene alternative splicing isoforms for FBXO30
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Expression for FBXO30 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FBXO30 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTCAATAAC
About this image FBXO30 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See FBXO30 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXO30 SOURCE GeneReport for Unigene cluster: Hs.421095 SABiosciences Expression via Pathway-Focused PCR Array including FBXO30 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FBXO30Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FBXO30 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FBXO30 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FBXO30 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO30
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Orthologsfor FBXO30 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FBXO30 gene from 5/17 species (see all 17 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
FBXO301
F-box protein 30
75.98(n) 76.92(a)
 
421612 XM_419650.1 XP_419650.1
lizard (Anolis carolinensis)
Reptilia
FBXO306
--
72(a)
1 ↔ 1
1(207070383-207073660)
African clawed frog (Xenopus laevis)
Amphibia
Xl.143652
Xenopus laevis transcribed sequence with weak similarity more
78.06(n)
 
BM192793.1
zebrafish (Danio rerio)
Actinopterygii
zgc636562
similar to F-box protein 30
75.44(n)
 
394126 BC055189.1
worm (Caenorhabditis elegans)
Secernentea
C10E2.26
Protein C10E2.2
21(a)
1 → many
X(16745666-16748135)
ENSEMBL Gene Tree for FBXO30 (if available)TreeFam Gene Tree for FBXO30 (if available)
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Paralogsfor FBXO30 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FBXO30 gene FBXO40 2 1 SIMAP similar gene for FBXO30 using alignment to 1 protein entry: FBX30_HUMAN :FBXO40
FBXO30 for paralogs About GeneDecksing
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Genomic Variantsfor FBXO30 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FBXO30 (146119271 - 146135921 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FBXO30: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FBXO30
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Disorders
/ Diseasesfor FBXO30 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FBXO30 for disorders About GeneDecksing
OMIM gene information: 609101
OMIM disorders : --2 diseases for FBXO30 : About MalaCards nasopharyngitis carcinoma Export disorders for FBXO30 gene to outside databases
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Publicationsfor FBXO30 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FBXO30 gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with FBXO30) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A human MAP kinase interactome. (PubMed id 20936779) 1 Bandyopadhyay S....Ideker T. (2010) Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068) 1 Hutchins J.R....Peters J.M. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PubMed id 18247557) 1 Jones J....Huang L. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008)
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External Searches for FBXO30 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FBXO30 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FBXO30 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FBXO30 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for FBXO30 gene: Search GeneIP for patents involving FBXO30 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FBXO30 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FBXO30 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FBXO30 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FBXO30 OriGene Protein Over-expression Lysate for FBXO30 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FBXO30 OriGene 3'-UTR Clone for FBXO30 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO30 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO30 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FBXO30 OriGene Custom Protein Services for FBXO30 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO30 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FBXO30 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FBXO30 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FBXO30 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FBXO30 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FBXO30
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FBXO30 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO30
Search ThermoFisher Antibodies for FBXO30
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO30
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Aliases for FBXO30
Databases for FBXO30
Disorders / Diseases for FBXO30
Domains / Families for FBXO30
Drugs / Compounds for FBXO30
Expression for FBXO30
Function for FBXO30
Genomic Views for FBXO30
Intellectual Property for FBXO30
Orthologs for FBXO30
Paralogs for FBXO30
Pathways / Interactions for FBXO30
Products for FBXO30
Proteins for FBXO30
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Summaries for FBXO30
Transcripts for FBXO30
Variants for FBXO30
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