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Aliases for FBXO30 Gene

Aliases for FBXO30 Gene

  • F-Box Protein 30 2 3
  • FBX30 3 4 6
  • F-Box Only Protein, Helicase, 18 2 3
  • F-Box Only Protein 30 3
  • F-Box Domain Protein 3

External Ids for FBXO30 Gene

Summaries for FBXO30 Gene

Entrez Gene Summary for FBXO30 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO30 Gene

FBXO30 (F-Box Protein 30) is a Protein Coding gene. Diseases associated with FBXO30 include nasopharyngeal carcinoma and colorectal cancer. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXO40.

UniProtKB/Swiss-Prot for FBXO30 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO30 Gene

Genomics for FBXO30 Gene

Genomic Location for FBXO30 Gene

Start:
145,793,502 bp from pter
End:
145,864,407 bp from pter
Size:
70,906 bases
Orientation:
Minus strand

Genomic View for FBXO30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO30 Gene

Regulatory Elements for FBXO30 Gene

Proteins for FBXO30 Gene

  • Protein details for FBXO30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB52-FBX30_HUMAN
    Recommended name:
    F-box only protein 30
    Protein Accession:
    Q8TB52
    Secondary Accessions:
    • Q9BXZ7

    Protein attributes for FBXO30 Gene

    Size:
    745 amino acids
    Molecular mass:
    82304 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1 (By similarity).
    SequenceCaution:
    • Sequence=AAK30299.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK30299.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBXO30 Gene

neXtProt entry for FBXO30 Gene

Proteomics data for FBXO30 Gene at MOPED

Post-translational modifications for FBXO30 Gene

Other Protein References for FBXO30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO30 Gene

Domains for FBXO30 Gene

Gene Families for FBXO30 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO30 Gene

UniProtKB/Swiss-Prot:

FBX30_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q8TB52
Similarity:
  • Contains 1 TRAF-type zinc finger.:
    • Q8TB52
genes like me logo Genes that share domains with FBXO30: view

Function for FBXO30 Gene

Molecular function for FBXO30 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

Gene Ontology (GO) - Molecular Function for FBXO30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with FBXO30: view

Phenotypes for FBXO30 Gene

genes like me logo Genes that share phenotypes with FBXO30: view

miRNA for FBXO30 Gene

miRTarBase miRNAs that target FBXO30

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO30 Gene

Localization for FBXO30 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO30 Gene COMPARTMENTS Subcellular localization image for FBXO30 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for FBXO30 Gene

Pathways for FBXO30 Gene

SuperPathways for FBXO30 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TB52-FBX30_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXO30: view

No data available for Pathways by source for FBXO30 Gene

Transcripts for FBXO30 Gene

mRNA/cDNA for FBXO30 Gene

Unigene Clusters for FBXO30 Gene

F-box protein 30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO30 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: - -
SP2:

Relevant External Links for FBXO30 Gene

GeneLoc Exon Structure for
FBXO30
ECgene alternative splicing isoforms for
FBXO30

Expression for FBXO30 Gene

mRNA expression in normal human tissues for FBXO30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO30 Gene

This gene is overexpressed in Esophagus - Muscularis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO30 Gene

SOURCE GeneReport for Unigene cluster for FBXO30 Gene Hs.421095

genes like me logo Genes that share expressions with FBXO30: view

Orthologs for FBXO30 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO30 36
  • 99.64 (n)
  • 99.73 (a)
FBXO30 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO30 36
  • 90.84 (n)
  • 91.24 (a)
FBXO30 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO30 36
  • 92.51 (n)
  • 92.46 (a)
FBXO30 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo30 36
  • 88.68 (n)
  • 88.41 (a)
Fbxo30 16
Fbxo30 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO30 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO30 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo30 36
  • 88.08 (n)
  • 88.35 (a)
chicken
(Gallus gallus)
Aves FBXO30 36
  • 75.89 (n)
  • 77.19 (a)
FBXO30 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO30 37
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14365 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo30 36
  • 69.47 (n)
  • 72.09 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo30a 36
  • 62.69 (n)
  • 65.59 (a)
fbxo30a 37
  • 60 (a)
OneToOne
zgc63656 36
Species with no ortholog for FBXO30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO30 Gene

ENSEMBL:
Gene Tree for FBXO30 (if available)
TreeFam:
Gene Tree for FBXO30 (if available)

Paralogs for FBXO30 Gene

Paralogs for FBXO30 Gene

Selected SIMAP similar genes for FBXO30 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FBXO30: view

Variants for FBXO30 Gene

Sequence variations from dbSNP and Humsavar for FBXO30 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_020410 -
VAR_024443 -
VAR_036072 A colorectal cancer sample
VAR_049044 -

Relevant External Links for FBXO30 Gene

HapMap Linkage Disequilibrium report
FBXO30

No data available for Structural Variations from Database of Genomic Variants (DGV) for FBXO30 Gene

Disorders for FBXO30 Gene

genes like me logo Genes that share disorders with FBXO30: view

No data available for UniProtKB/Swiss-Prot for FBXO30 Gene

Publications for FBXO30 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. [Study on the fusion expression of FBXO30: a novel member of F-box protein family]. (PMID: 12536519) Li Z.H. … Li G.Y. (Hunan Yi Ke Da Xue Xue Bao 2001) 3

Products for FBXO30 Gene

Sources for FBXO30 Gene

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