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Aliases for FBXO30 Gene

Aliases for FBXO30 Gene

  • F-Box Protein 30 2 3 5
  • F-Box Only Protein, Helicase, 18 2 3
  • Fbx30 3 4
  • F-Box Domain Protein 3

External Ids for FBXO30 Gene

Previous GeneCards Identifiers for FBXO30 Gene

  • GC06M145742
  • GC06M145966
  • GC06M146099
  • GC06M146160
  • GC06M143682

Summaries for FBXO30 Gene

Entrez Gene Summary for FBXO30 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO30 Gene

FBXO30 (F-Box Protein 30) is a Protein Coding gene. Diseases associated with FBXO30 include Nasopharyngeal Carcinoma. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXO40.

UniProtKB/Swiss-Prot for FBXO30 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO30 Gene

Genomics for FBXO30 Gene

Regulatory Elements for FBXO30 Gene

Enhancers for FBXO30 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO30 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO30 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO30 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO30 Gene

145,793,502 bp from pter
145,814,786 bp from pter
21,285 bases
Minus strand

Genomic View for FBXO30 Gene

Genes around FBXO30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO30 Gene

Proteins for FBXO30 Gene

  • Protein details for FBXO30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 30
    Protein Accession:
    Secondary Accessions:
    • Q9BXZ7

    Protein attributes for FBXO30 Gene

    745 amino acids
    Molecular mass:
    82304 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1, CUL1 and RBX1/ROC1 (By similarity).
    • Sequence=AAK30299.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK30299.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBXO30 Gene

neXtProt entry for FBXO30 Gene

Proteomics data for FBXO30 Gene at MOPED

Post-translational modifications for FBXO30 Gene

Other Protein References for FBXO30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO30 Gene

Domains & Families for FBXO30 Gene

Gene Families for FBXO30 Gene

Protein Domains for FBXO30 Gene

Suggested Antigen Peptide Sequences for FBXO30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 TRAF-type zinc finger.
  • Contains 1 F-box domain.
  • Contains 1 TRAF-type zinc finger.
genes like me logo Genes that share domains with FBXO30: view

Function for FBXO30 Gene

Molecular function for FBXO30 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
genes like me logo Genes that share phenotypes with FBXO30: view

Animal Model Products

miRNA for FBXO30 Gene

miRTarBase miRNAs that target FBXO30

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO30 Gene

Localization for FBXO30 Gene

Subcellular locations from

Jensen Localization Image for FBXO30 Gene COMPARTMENTS Subcellular localization image for FBXO30 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO30 Gene

Pathways & Interactions for FBXO30 Gene

SuperPathways for FBXO30 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TB52-FBX30_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO30 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO30 Gene

Drugs & Compounds for FBXO30 Gene

No Compound Related Data Available

Transcripts for FBXO30 Gene

mRNA/cDNA for FBXO30 Gene

Unigene Clusters for FBXO30 Gene

F-box protein 30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO30 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: - -

Relevant External Links for FBXO30 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO30 Gene

mRNA expression in normal human tissues for FBXO30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO30 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.1).

Protein differential expression in normal tissues from HIPED for FBXO30 Gene

This gene is overexpressed in Testis (14.1), Colon (12.4), Rectum (9.8), Gallbladder (7.9), Placenta (6.6), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO30 Gene

SOURCE GeneReport for Unigene cluster for FBXO30 Gene Hs.421095

genes like me logo Genes that share expression patterns with FBXO30: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXO30 Gene

Orthologs for FBXO30 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO30 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO30 35
  • 90.84 (n)
  • 91.24 (a)
FBXO30 36
  • 91 (a)
(Canis familiaris)
Mammalia FBXO30 35
  • 92.51 (n)
  • 92.46 (a)
FBXO30 36
  • 92 (a)
(Mus musculus)
Mammalia Fbxo30 35
  • 88.68 (n)
  • 88.41 (a)
Fbxo30 16
Fbxo30 36
  • 88 (a)
(Pan troglodytes)
Mammalia FBXO30 35
  • 99.64 (n)
  • 99.73 (a)
FBXO30 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo30 35
  • 88.08 (n)
  • 88.35 (a)
(Monodelphis domestica)
Mammalia FBXO30 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO30 36
  • 79 (a)
(Gallus gallus)
Aves FBXO30 35
  • 75.89 (n)
  • 77.19 (a)
FBXO30 36
  • 75 (a)
(Anolis carolinensis)
Reptilia FBXO30 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo30 35
  • 69.47 (n)
  • 72.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14365 35
(Danio rerio)
Actinopterygii fbxo30a 35
  • 62.69 (n)
  • 65.59 (a)
zgc63656 35
fbxo30a 36
  • 60 (a)
Species with no ortholog for FBXO30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO30 Gene

Gene Tree for FBXO30 (if available)
Gene Tree for FBXO30 (if available)

Paralogs for FBXO30 Gene

Paralogs for FBXO30 Gene

(1) SIMAP similar genes for FBXO30 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FBXO30: view

Variants for FBXO30 Gene

Sequence variations from dbSNP and Humsavar for FBXO30 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_020410 -
VAR_024443 -
VAR_036072 A colorectal cancer sample
VAR_049044 -

Variation tolerance for FBXO30 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FBXO30 Gene

Disorders for FBXO30 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO30 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • malignant neoplasm of nasopharynx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXO30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO30 Gene

Publications for FBXO30 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for FBXO30 Gene

Sources for FBXO30 Gene