Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO30 Gene

protein-coding   GIFtS: 45
GCID: GC06M146160

F-Box Protein 30

(Previous names: F-box only protein, helicase, 18)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 301 2
F-Box Only Protein, Helicase, 181 2
FBX303 5
Fbx302
F-Box Domain Protein2
F-Box Only Protein 302

External Ids:    HGNC: 156001   Entrez Gene: 840852   Ensembl: ENSG000001184967   OMIM: 6091015   UniProtKB: Q8TB523   

Export aliases for FBXO30 gene to outside databases

Previous GC identifers: GC06M145742 GC06M145966 GC06M146099 GC06M143682


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO30 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. (provided by RefSeq, Jul
2008)

GeneCards Summary for FBXO30 Gene: 
FBXO30 (F-box protein 30) is a protein-coding gene. Diseases associated with FBXO30 include nasopharyngitis. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is FBXO40.

UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO30 gene promoter:
         FOXO3   Nkx2-5   NF-kappaB   FOXO3b   AREB6   c-Rel   NF-kappaB2   Sox9   FOXO3a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO30 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO30

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24   Ensembl cytogenetic band:  6q24.3   HGNC cytogenetic band: 6q24

FBXO30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO30 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M146160:  view genomic region     (about GC identifiers)

Start:
146,114,638 bp from pter      End:
146,135,921 bp from pter
Size:
21,284 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52 (See protein sequence)
Recommended Name: F-box only protein 30  
Size: 745 amino acids; 82304 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Sequence caution: Sequence=AAK30299.1; Type=Erroneous initiation; Sequence=AAK30299.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
1 PDB 3D structure from and Proteopedia for FBXO30:
2YRE (3D)    
Secondary accessions: Q9BXZ7

Explore the universe of human proteins at neXtProt for FBXO30: NX_Q8TB52

Explore proteomics data for FBXO30 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TB52

  • FBXO30 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO30 Protein Expression
    REFSEQ proteins: NP_115521.3  
    ENSEMBL proteins: 
     ENSP00000237281  

    Human Recombinant Protein Products for FBXO30: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBXO30
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FBXO30
    GenScript Custom Purified and Recombinant Proteins Services for FBXO30
    Novus Biologicals FBXO30 Proteins
    Novus Biologicals FBXO30 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO30 


    FBXO30 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXO30
    GenScript Custom Superior Antibodies Services for FBXO30
    Novus Biologicals FBXO30 Antibodies
    Search for Antibodies for FBXO30 at Abcam
    Cloud-Clone Corp. Antibodies for FBXO30 
    Search ThermoFisher Antibodies for FBXO30
    Search LSBio for Antibodies for FBXO30 

    Assay Products for FBXO30: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXO30
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXO30
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXO30 
    Cloud-Clone Corp. CLIAs for FBXO30


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    4 InterPro protein domains:
     IPR008974 TRAF-like
     IPR001810 F-box_dom_cyclin-like
     IPR001293 Znf_TRAF
     IPR013323 SIAH-type

    Graphical View of Domain Structure for InterPro Entry Q8TB52

    ProtoNet protein and cluster: Q8TB52

    UniProtKB/Swiss-Prot: FBX30_HUMAN, Q8TB52
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 TRAF-type zinc finger


    FBXO30 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX30_HUMAN, Q8TB52
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    FBXO30 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXO30:
     Decreased Salmonella enterica   Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO30 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO30

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO30 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO30 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO30
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO30 (see all 41):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-607 hsa-miR-219-5p hsa-miR-449a hsa-miR-570 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidFBXO30 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXO30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO30

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXO30
    Sirion Biotech Customized adenovirus for overexpression of FBXO30

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FBXO30 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO30 (NM_032145)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO30
    Sirion Biotech Customized lentivirus for stable overexpression of FBXO30 
                         Customized lentivirus expression plasmids for stable overexpression of FBXO30 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXO30
    Search LifeMap BioReagents cell lines for FBXO30
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO30


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO30

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/18 Interacting proteins for FBXO30 (Q8TB523 ENSP000002372814) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    SMAD1Q157973, ENSP000003057694I2D: score=3 STRING: ENSP00000305769
    SMAD4Q134853, ENSP000003415514I2D: score=3 STRING: ENSP00000341551
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO30 (FBX30)

    Search CenterWatch for drugs/clinical trials and news about FBXO30 / FBX30

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO30 gene: 
    NM_032145.4  

    Unigene Cluster for FBXO30:

    F-box protein 30
    Hs.421095  [show with all ESTs]
    Unigene Representative Sequence: NM_032145
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000237281(uc003qla.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO30
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO30 (see all 41):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-607 hsa-miR-219-5p hsa-miR-449a hsa-miR-570 hsa-miR-374c hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidFBXO30 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXO30
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO30
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO30 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO30
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO30 (NM_032145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO30
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO30
    Sirion Biotech Customized lentivirus for stable overexpression of FBXO30 
                         Customized lentivirus expression plasmids for stable overexpression of FBXO30 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXO30
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO30
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO30
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO30
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO30

    Additional mRNA sequence: 

    AF248640.1 AK055919.1 AK123026.1 AK124138.1 AK313613.1 BC024326.1 

    5 DOTS entries:

    DT.97763315  DT.441895  DT.100812915  DT.100812916  DT.95081720 

    24/97 AceView cDNA sequences (see all 97):

    AW073863 BU676497 AA120797 NM_032145 AA282584 BQ937523 AL602397 BE222001 
    AI689778 BC024326 BF970337 BG107447 AA282520 BQ437745 AW149932 AI160733 
    AK123026 AA649164 BE466016 AI911351 BQ008946 AI291414 AK124138 CF528645 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO30    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:        -     -                     
    SP2:                                    


    ECgene alternative splicing isoforms for FBXO30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO30 expression in normal human tissues (normalized intensities)      FBXO30 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCAATAAC
    FBXO30 Expression
    About this image


    FBXO30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)
             aorta   
     
     Kidney (Reproductive System)
             visceral organ/mesonephros of female/mesonephric mesenchyme of female mesonephros   
     
     Gonad
             Mesonephric cells Mesonephros

    See FBXO30 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO30

    SOURCE GeneReport for Unigene cluster: Hs.421095
        SABiosciences Expression via Pathway-Focused PCR Array including FBXO30: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXO30
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO30
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO30
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO30
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO30
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO30

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO30 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo301 , 5 F-box protein 301, 5 88.68(n)1
    88.41(a)1
      10 (3.66 cM)5
    718651  NM_001168297.11  NP_001161769.11 
     112813305 
    chicken
    (Gallus gallus)
    Aves FBXO301 F-box protein 30 75.98(n)
    76.92(a)
      421612  XM_419650.1  XP_419650.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO306
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(207070383-207075700)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143652 Xenopus laevis transcribed sequence with weak similarity more 78.06(n)    BM192793.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636562 similar to F-box protein 30 75.44(n)   394126  BC055189.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C10E2.26
    Protein C10E2.2
    21(a)
    1 → many
    X(16745739-16748208)


    ENSEMBL Gene Tree for FBXO30 (if available)
    TreeFam Gene Tree for FBXO30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO30 gene
    FBXO402  
    1 SIMAP similar gene for FBXO30 using alignment to 1 protein entry:     FBX30_HUMAN:
    FBXO40

    FBXO30 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    4 SNPs in FBXO30 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360724
    A colorectal cancer sample4--see VAR_0360722 S C mis40--------
    VAR_0204104
    ----see VAR_0204102 H Q mis40--------
    VAR_0244434
    ----see VAR_0244432 V M mis40--------
    VAR_0490444
    ----see VAR_0490442 S C mis40--------

    HapMap Linkage Disequilibrium report for FBXO30 (146114638 - 146135921 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for FBXO30: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO30
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609101    OMIM disorders: --

    2 diseases for FBXO30:    About MalaCards
    nasopharyngitis    


    FBXO30 for disorders           About GeneDecksing


    Export disorders for FBXO30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO30 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with FBXO30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    6. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PubMed id 18247557)1 Jones J....Huang L. (2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84085 HGNC: 15600 AceView: FBXO30 Ensembl:ENSG00000118496 euGenes: HUgn84085
    ECgene: FBXO30 H-InvDB: FBXO30

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO30 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FBXO30 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO30 gene:
    Search GeneIP for patents involving FBXO30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXO30  
     OriGene qPCR primer pairs and template standards for FBXO30   OriGene Protein Over-expression Lysate for FBXO30  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXO30  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXO30   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXO30   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXO30   OriGene Custom Protein Services for FBXO30  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO30
     QIAGEN SeqTarget long-range PCR primers for resequencing FBXO30
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO30
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO30
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO30
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO30
     GenScript Custom Purified and Recombinant Proteins Services for FBXO30 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO30
     GenScript Custom Assay Services for FBXO30 GenScript Custom Superior Antibodies Services for FBXO30
     GenScript Custom overexpressing Cell Line Services for FBXO30 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXO30 promoter
     Search Chromatin IP Primers for FBXO30
     RT2 qPCR Primer Assay in human, mouse, rat FBXO30
     Search GNC Networks for FBXO30
     SABiosciences PCR Arrays including human, mouse, rat FBXO30
     Search Tocris compounds for FBXO30 (FBX30)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FBXO30 antibodies
     FBXO30 proteins
     FBXO30 lysates
     Search for Antibodies for FBXO30 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FBXO30
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FBXO30
     Antibodies for FBXO30
     ELISAs for FBXO30
     CLIAs for FBXO30
     Search LifeMap BioReagents cell lines for FBXO30
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO30
     SwitchGear 3'UTR luciferase reporter plasmids for FBXO30
     SwitchGear Promoter luciferase reporter plasmids for FBXO30
     Search ThermoFisher Antibodies for FBXO30
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO30
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO30
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO30
    Customized:
     lentivirus for stable overexpression of FBXO30
     lentivirus expression plasmids for stable overexpression of FBXO30
     adenovirus for overexpression of FBXO30
     Search LSBio for Antibodies for FBXO30
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXO30 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4