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Aliases for FBXO3 Gene

Aliases for FBXO3 Gene

  • F-Box Protein 3 2 3
  • FBX3 3 4 6
  • F-Box Only Protein 3 2 3
  • FBA 3 6
  • F-Box Protein FBX3 3

External Ids for FBXO3 Gene

Previous GeneCards Identifiers for FBXO3 Gene

  • GC11M035294
  • GC11M034440
  • GC11M033801
  • GC11M033726
  • GC11M033719
  • GC11M033458

Summaries for FBXO3 Gene

Entrez Gene Summary for FBXO3 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO3 Gene

FBXO3 (F-Box Protein 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO3 Gene

  • Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO3 Gene

Genomics for FBXO3 Gene

Regulatory Elements for FBXO3 Gene

Transcription factor binding sites by QIAGEN in the FBXO3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO3 Gene

Start:
33,740,939 bp from pter
End:
33,774,543 bp from pter
Size:
33,605 bases
Orientation:
Minus strand

Genomic View for FBXO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO3 Gene

Proteins for FBXO3 Gene

  • Protein details for FBXO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK99-FBX3_HUMAN
    Recommended name:
    F-box only protein 3
    Protein Accession:
    Q9UK99
    Secondary Accessions:
    • B3KY16
    • D3DR05
    • Q86X90
    • Q9H0V2
    • Q9NUX2

    Protein attributes for FBXO3 Gene

    Size:
    471 amino acids
    Molecular mass:
    54561 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex.

    Alternative splice isoforms for FBXO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO3 Gene

Proteomics data for FBXO3 Gene at MOPED

Post-translational modifications for FBXO3 Gene

  • Ubiquitination at Lys218 and Lys390
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO3 Gene

No data available for DME Specific Peptides for FBXO3 Gene

Domains for FBXO3 Gene

Gene Families for FBXO3 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UK99

UniProtKB/Swiss-Prot:

FBX3_HUMAN :
  • Q9UK99
Domain:
  • Contains 1 apaG domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO3: view

Function for FBXO3 Gene

Molecular function for FBXO3 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Gene Ontology (GO) - Molecular Function for FBXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FBXO3: view

Phenotypes for FBXO3 Gene

GenomeRNAi human phenotypes for FBXO3:
genes like me logo Genes that share phenotypes with FBXO3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO3 Gene

Localization for FBXO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO3 Gene

Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO3 Gene COMPARTMENTS Subcellular localization image for FBXO3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FBXO3: view

Pathways for FBXO3 Gene

genes like me logo Genes that share pathways with FBXO3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FBXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXO3: view

Transcripts for FBXO3 Gene

Unigene Clusters for FBXO3 Gene

F-box protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -

Relevant External Links for FBXO3 Gene

GeneLoc Exon Structure for
FBXO3
ECgene alternative splicing isoforms for
FBXO3

Expression for FBXO3 Gene

mRNA expression in normal human tissues for FBXO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO3 Gene

SOURCE GeneReport for Unigene cluster for FBXO3 Gene Hs.406787

genes like me logo Genes that share expressions with FBXO3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO3 Gene

Orthologs for FBXO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO3 35
  • 99.79 (n)
  • 100 (a)
FBXO3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO3 35
  • 91.97 (n)
  • 96.59 (a)
FBXO3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO3 35
  • 94.62 (n)
  • 98.94 (a)
FBXO3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo3 35
  • 86.77 (n)
  • 92.14 (a)
Fbxo3 16
Fbxo3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo3 35
  • 87.97 (n)
  • 92.36 (a)
chicken
(Gallus gallus)
Aves FBXO3 35
  • 78.13 (n)
  • 83.54 (a)
FBXO3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO3 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1891 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo3 35
  • 66.58 (n)
  • 72.03 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo3 35
  • 68.66 (n)
  • 73.3 (a)
fbxo3 36
  • 67 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SKIP16 35
  • 41.86 (n)
  • 27.44 (a)
rice
(Oryza sativa)
Liliopsida Os11g0265200 35
  • 40.5 (n)
  • 28.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for FBXO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO3 Gene

ENSEMBL:
Gene Tree for FBXO3 (if available)
TreeFam:
Gene Tree for FBXO3 (if available)

Paralogs for FBXO3 Gene

Selected SIMAP similar genes for FBXO3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FBXO3 Gene

genes like me logo Genes that share paralogs with FBXO3: view

No data available for Paralogs for FBXO3 Gene

Variants for FBXO3 Gene

Sequence variations from dbSNP and Humsavar for FBXO3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs704702 -- 33,744,351(+) ACACA(C/G)AGAGG intron-variant
rs704703 -- 33,744,949(+) ccacC(A/G)TCCTT intron-variant
rs831592 -- 33,741,647(+) TGTCC(A/G)TTCCT utr-variant-3-prime
rs831593 -- 33,742,426(+) ATCCT(C/T)CCGAG intron-variant
rs831594 -- 33,743,667(+) CACAT(C/T)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO3 Gene

Variant ID Type Subtype PubMed ID
nsv832113 CNV Gain 17160897
nsv523356 CNV Loss 19592680

Relevant External Links for FBXO3 Gene

HapMap Linkage Disequilibrium report
FBXO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO3 Gene

Disorders for FBXO3 Gene

(1) University of Copenhagen DISEASES for FBXO3 Gene

Relevant External Links for FBXO3

Genetic Association Database (GAD)
FBXO3
Human Genome Epidemiology (HuGE) Navigator
FBXO3
genes like me logo Genes that share disorders with FBXO3: view

No data available for UniProtKB/Swiss-Prot for FBXO3 Gene

Publications for FBXO3 Gene

  1. PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PMID: 18809579) Shima Y. … Kitabayashi I. (Mol. Cell. Biol. 2008) 3 4 23
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for FBXO3 Gene

Sources for FBXO3 Gene

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