Aliases for FBXO3 Gene
Aliases for FBXO3 Gene
External Ids for FBXO3 Gene
- HGNC: 13582
- Entrez Gene: 26273
- Ensembl: ENSG00000110429
- OMIM: 609089
- UniProtKB: Q9UK99
Previous GeneCards Identifiers for FBXO3 Gene
- GC11M035294
- GC11M034440
- GC11M033801
- GC11M033726
- GC11M033719
- GC11M033458
Summaries for FBXO3 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXO3 Gene
FBXO3 (F-Box Protein 3) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXO3 Gene
-
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO3 Gene
Genomics for FBXO3 Gene
Regulatory Elements for FBXO3 Gene
Enhancers for FBXO3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO3 gene promoter:
Regulatory Element Products
Genomic Location for FBXO3 Gene
- Chromosome:
- 11
- Start:
- 33,740,939 bp from pter
- End:
- 33,774,543 bp from pter
- Size:
- 33,605 bases
- Orientation:
- Minus strand
Genomic View for FBXO3 Gene
Genes around FBXO3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p13 by Ensembl
- 11p13 by Entrez Gene
- 11p13 by HGNC
FBXO3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO3 Gene
Proteins for FBXO3 Gene
-
Protein details for FBXO3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UK99-FBX3_HUMAN
- Recommended name:
- F-box only protein 3
- Protein Accession:
- Q9UK99
- B3KY16
- D3DR05
- Q86X90
- Q9H0V2
- Q9NUX2
Protein attributes for FBXO3 Gene
- Size:
- 471 amino acids
- Molecular mass:
- 54561 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex.
Protein Expression for FBXO3 Gene
Post-translational modifications for FBXO3 Gene
Other Protein References for FBXO3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO3
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- antibodies-online Antibodies for FBXO3: See all 33
- GeneTex FBXO3 antibody for FBXO3
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXO3
Protein Products
-
OriGene Purified Proteins for FBXO3
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXO3
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-
Cloud-Clone Corp. Proteins for FBXO3
- antibodies-online Proteins for FBXO3: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO3
Assay Products
- antibodies-online Kits for FBXO3: See all 15
No data available for DME Specific Peptides for FBXO3 Gene
Domains & Families for FBXO3 Gene
Gene Families for FBXO3 Gene
- HGNC:
Protein Domains for FBXO3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO3 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO3 Gene
Function for FBXO3 Gene
Molecular function for FBXO3 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | 10531035 |
| GO:0005515 | protein binding | IPI | 21516116 |
Phenotypes for FBXO3 Gene
- GenomeRNAi human phenotypes for FBXO3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO3 gene
- Search ViGene Biosciences for FBXO3
CRISPR Products
-
OriGene CRISPR knockouts for FBXO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO3
- GenScript: Design CRISPR guide RNA sequences for FBXO3
miRNA for FBXO3 Gene
- miRTarBase miRNAs that target FBXO3
miRNA Products
- Search ViGene Biosciences for FBXO3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FBXO3
- Browse OriGene Inhibitory RNA Products For FBXO3
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO3 gene
Clone Products
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Cell Line Products
-
Horizon Cell Lines for FBXO3
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO3 Gene
Localization for FBXO3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXO3 Gene
- Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for FBXO3 Gene
No Data Available
Interacting Proteins for FBXO3 Gene
Selected Interacting proteins:
Q9UK99-FBX3_HUMAN
ENSP00000265651
for FBXO3 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | TAS | 10531035 |
| GO:0016567 | protein ubiquitination | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FBXO3 Gene
Transcripts for FBXO3 Gene
mRNA/cDNA for FBXO3 Gene
- (6) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (213) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO3
- GenScript: Design CRISPR guide RNA sequences for FBXO3
miRNA Products
- Search ViGene Biosciences for FBXO3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FBXO3
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO3 gene
Clone Products
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - |
Expression for FBXO3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
- Primordial Germ Cell Precursors Epiblast
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
- Intraembryonic Epiblast Cells Epiblast
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
This gene is overexpressed in Heart (12.1), Peripheral blood mononuclear cells (11.5), Placenta (7.2), and Frontal cortex (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO3 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO3 Gene:
FBXO3SOURCE GeneReport for Unigene cluster for FBXO3 Gene:
Hs.406787Evidence on tissue expression from TISSUES for FBXO3 Gene
- Nervous system(4.9)
- Kidney(2.1)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for FBXO3
-
OriGene qPCR primer pairs and template standards for FBXO3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO3 Gene
Orthologs for FBXO3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO3 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fbxo3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo3 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FBXO3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo3 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1891 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo3 34 35 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SKIP16 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0265200 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXO3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO3 Gene
(2) SIMAP similar genes for FBXO3 Gene using alignment to 6 proteins:
Pseudogenes.org Pseudogenes for FBXO3 Gene
No data available for Paralogs for FBXO3 Gene
Variants for FBXO3 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005304 | -- | 33,769,984(+) | TCTCC(G/T)GTTTT | intron-variant | |
| rs1000030172 | -- | 33,775,729(+) | TCTCT(C/G)AATTA | downstream-variant-500B, upstream-variant-2KB | |
| rs1000159511 | -- | 33,762,746(+) | AATCA(-/C)AGTAA | intron-variant | |
| rs1000302687 | -- | 33,755,044(+) | TGTGT(C/T)TTTTT | intron-variant | |
| rs1000386894 | -- | 33,741,713(+) | TTCTT(C/T)CTCTA | utr-variant-3-prime |
Residual Variation Intolerance Score:
39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.45;
54.77% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO3 Gene
Disorders for FBXO3 Gene
Relevant External Links for FBXO3
No disorders were found for FBXO3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO3 Gene
Publications for FBXO3 Gene
- PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PMID: 18809579) Shima Y. … Kitabayashi I. (Mol. Cell. Biol. 2008) 3 4 22 64
- A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
Products for FBXO3 Gene
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- antibodies-online Antibodies for FBXO3: See all 33
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- ViGene Biosciences adenoviral particle packaged cDNA for FBXO3 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for FBXO3
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- Horizon Cell Lines for FBXO3
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- VectorBuilder custom plasmid, inducible vectors for FBXO3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer