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FBXO3 Gene

protein-coding   GIFtS: 58
GCID: GC11M033762

F-Box Protein 3

(Previous name: F-box only protein 3)
  Search for FBXO3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 31 2
FBX32 3 5
F-Box Only Protein 31 2
FBA2 5
F-Box Protein FBX32

External Ids:    HGNC: 135821   Entrez Gene: 262732   Ensembl: ENSG000001104297   OMIM: 6090895   UniProtKB: Q9UK993   

Export aliases for FBXO3 gene to outside databases

Previous GC identifers: GC11M035294 GC11M034440 GC11M033801 GC11M033726 GC11M033719 GC11M033458


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO3 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging
at the 3' end. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO3 Gene:
FBXO3 (F-box protein 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99
Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome.
In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may
act synergically to activate p53/TP53-dependent transactivation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO3 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO3 promoter sequence
   Search Chromatin IP Primers for FBXO3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

FBXO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M033762:  view genomic region     (about GC identifiers)

Start:
33,762,485 bp from pter      End:
33,796,089 bp from pter
Size:
33,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99 (See protein sequence)
Recommended Name: F-box only protein 3  
Size: 471 amino acids; 54561 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1.
Interacts with PML, interaction is direct and takes place either alone or within the SCF complex
Secondary accessions: B3KY16 D3DR05 Q86X90 Q9H0V2 Q9NUX2
Alternative splicing: 3 isoforms:  Q9UK99-1   Q9UK99-2   Q9UK99-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO3: NX_Q9UK99

Explore proteomics data for FBXO3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys218, Lys390
  • Modification sites at PhosphoSitePlus

  • See FBXO3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036307.2  NP_208385.1  

    ENSEMBL proteins: 
     ENSP00000435680   ENSP00000265651   ENSP00000433781   ENSP00000435165   ENSP00000434001  
     ENSP00000431745   ENSP00000408836   ENSP00000434099   ENSP00000431502  
    Reactome Protein details: Q9UK99

    FBXO3 Human Recombinant Protein Products:

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    Novus Biologicals FBXO3 Proteins
    Novus Biologicals FBXO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    4 InterPro protein domains:
     IPR007474 ApaG_domain
     IPR028388 FBXO3
     IPR018958 SMI1/KNR4_like_dom
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UK99

    ProtoNet protein and cluster: Q9UK99

    1 Blocks protein domain: IPB007474 Protein of unknown function DUF525

    UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99
    Similarity: Contains 1 apaG domain
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX3_HUMAN, Q9UK99
    Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
    Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome.
    In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may
    act synergically to activate p53/TP53-dependent transactivation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FBXO3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO3:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO3
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    miRNA
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    miRTarBase miRNAs that target FBXO3:
    hsa-mir-15a-5p (MIRT051338), hsa-mir-16-5p (MIRT051071), hsa-mir-21-5p (MIRT030802), hsa-mir-26b-5p (MIRT029469), hsa-let-7d-5p (MIRT032115), hsa-mir-20a-5p (MIRT050537), hsa-mir-142-3p (MIRT021627), hsa-mir-192-5p (MIRT026514), hsa-mir-30b-5p (MIRT023410)

    Block miRNA regulation of human, mouse, rat FBXO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO3 (see all 15):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3146 hsa-miR-449c* hsa-miR-16-1* hsa-miR-219-5p hsa-miR-340 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFBXO3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO3
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO3 (NM_033406)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO3

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    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX3_HUMAN, Q9UK99: Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with FBXO3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXO3 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with FBXO3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FBXO3
        Antigen processing: Ubiquitination & Proteasome degradation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FBXO3 (Q9UK991, 3 ENSP000002656514) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-2509901,EBI-307486 I2D: score=2 STRING: ENSP00000231487
    RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
    TNIP3Q96KP63, ENSP000000575134I2D: score=1 STRING: ENSP00000057513
    TNFAIP3P215803, ENSP000002372894I2D: score=1 STRING: ENSP00000237289
    BMPR1BO002383I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10531035
    GO:0016567protein ubiquitination TAS10531035

    Find genes that share ontologies with FBXO3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO3 (FBX3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO3 gene (2 alternative transcripts): 
    NM_012175.3  NM_033406.2  

    Unigene Cluster for FBXO3:

    F-box protein 3
    Hs.406787  [show with all ESTs]
    Unigene Representative Sequence: AB209039
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526785(uc001muy.3) ENST00000265651(uc001muz.3) ENST00000530013(uc010rej.2 uc009ykb.3)
    ENST00000530401 ENST00000531080 ENST00000532057 ENST00000534136 ENST00000527772
    ENST00000448981(uc001mva.1 uc001mvb.1 uc010rek.1) ENST00000532927
    ENST00000529137 ENST00000533103 ENST00000526952
    miRNA
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    Block miRNA regulation of human, mouse, rat FBXO3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO3 (see all 15):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3146 hsa-miR-449c* hsa-miR-16-1* hsa-miR-219-5p hsa-miR-340 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFBXO3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for FBXO3
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO3
    Clone
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    OriGene clones in human, mouse for FBXO3 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO3 (NM_033406)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO3
    Primer
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    OriGene qPCR primer pairs and template standards for FBXO3
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO3
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO3
      QuantiFast Probe-based Assays in human, mouse, rat FBXO3

    Additional mRNA sequence: 

    AB209039.1 AF174595.1 AF176702.1 AK001943.1 AK123198.1 AK126592.1 AK128454.1 AK300721.1 
    AK304866.1 AK316286.1 AL136625.1 AL162053.1 AL832826.1 BC017107.1 BC039291.1 BC046110.1 

    13 DOTS entries:

    DT.113296  DT.95167441  DT.120743662  DT.100791026  DT.95167439  DT.92068892  DT.92437105  DT.100791020 
    DT.100008594  DT.100791023  DT.92437098  DT.99964935  DT.92437104 

    Selected AceView cDNA sequences (see all 213):

    AI927646 BM682032 W70091 AA514201 AI064809 CK905375 BU789273 BU159000 
    BM785637 BI759193 BM751273 AA328060 AK128454 BM677293 CA438477 BM509064 
    BM723757 BF221555 AI480330 AI480396 BQ575635 BM729102 AA002068 BM552179 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c
    SP1:              -                                                                       -     -                     
    SP2:              -                                         -                             -     -                     
    SP3:              -     -                                   -                                                         
    SP4:              -                                         -                                                         
    SP5:                                                        -                             -     -                     


    ECgene alternative splicing isoforms for FBXO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTATGT
    FBXO3 Expression
    About this image


    FBXO3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    FBXO3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406787
        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXO3
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO3
    QuantiTect SYBR Green Assays in human, mouse, rat FBXO3
    QuantiFast Probe-based Assays in human, mouse, rat FBXO3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FBXO3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo31 , 5 F-box protein 31, 5 86.77(n)1
    92.14(a)1
      2 (54.49 cM)5
    574431  NM_212433.11  NP_997598.11 
     1040277215 
    chicken
    (Gallus gallus)
    Aves FBXO31 F-box protein 3 78.13(n)
    83.54(a)
      429495  XM_427051.4  XP_427051.4 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO36
    F-box protein 3
    76(a)
    1 ↔ 1
    GL343283.1(1007073-1025926)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.18912 Xenopus laevis transcribed sequence with weak similarity more 76.19(n)    BQ384336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo31 F-box protein 3 68.66(n)
    73.3(a)
      553731  NM_001020702.1  NP_001018538.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SKIP161 SKIP16 41.86(n)
    27.44(a)
      837120  NM_100492.3  NP_563759.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g02652001 Os11g0265200 40.5(n)
    28.23(a)
      4350244  NM_001074190.2  NP_001067658.2 


    ENSEMBL Gene Tree for FBXO3 (if available)
    TreeFam Gene Tree for FBXO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO3 gene
    2 SIMAP similar genes for FBXO3 using alignment to 6 protein entries:     FBX3_HUMAN (see all proteins):
    FBX3    DKFZp586F1524

    Find genes that share paralogs with FBXO3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FBXO3
    PGOHUM00000257946


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO3 (see all 633)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122773201,2
    C,F,A,H--33762050(+) atcacA/Gctacc 1 -- ds50015Minor allele frequency- G:0.04NS EA WA 534
    rs2022348501,2
    --33762107(+) AAAAA-/AAAAG 
            
    GATAG
    1 -- ds50010--------
    rs586980351,2
    C--33762108(+) AAAAA-/AAAG  
            
    GATAG
    1 -- ds50010--------
    rs608366871,2
    C--33762110(+) AAAAA-/AAAA  
     
    /AAAAAA
    GGATA
    2 -- ds5001 cds11NA 2
    rs753643061,2
    C--33762111(+) AAAAAG/AGATAG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1818581791,2
    --33762377(+) TGAGTA/GGACCT 1 -- ds50010--------
    rs1864213491,2
    --33762427(+) TCTACC/TTTAAA 1 -- ds50010--------
    rs1904259461,2
    --33762463(+) ATGGAA/TAATAA 1 -- ds50010--------
    rs1482197421,2
    --33762470(+) ATAAGC/TAATTA 1 -- ds50010--------
    rs1822695191,2
    --33762585(+) CAAGTG/TTCAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXO3 (33762485 - 33796089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXO3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523356CNV Loss19592680
    nsv832113CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO3
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609089    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for FBXO3:
    Candidiasis

    Find genes that share disorders with FBXO3           About GenesLikeMe

    Genetic Association Database (GAD): FBXO3
    Human Genome Epidemiology (HuGE) Navigator: FBXO3 (1 document)

    Export disorders for FBXO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with FBXO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    2. PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PubMed id 18809579)1, 2, 9 Shima Y....Kitabayashi I. (Mol. Cell. Biol. 2008)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. (PubMed id 23542741)1 Chen B.B....Mallampalli R.K. (Nat. Immunol. 2013)
    7. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26273 HGNC: 13582 AceView: FBXO3 Ensembl:ENSG00000110429 euGenes: HUgn26273
    ECgene: FBXO3 H-InvDB: FBXO3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO3 gene:
    Search GeneIP for patents involving FBXO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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