Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FBXO3 Gene

protein-coding GIFtS: 54
GCID: GC11M033762

F-box protein 3

(Previous name: F-box only protein 3 )

Explore 2 diseases affiliated with
FBXO3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
F-Box Protein 3¹ ²
FBX3¹ ² ³ ⁵
FBA¹ ² ⁵
F-Box Only Protein 3¹ ²
F-Box Protein FBX3²

External Ids:	HGNC: 13582¹	Entrez Gene: 26273²	Ensembl: ENSG00000110429⁷	OMIM: 609089⁵	UniProtKB: Q9UK99³

Export aliases for FBXO3 gene to outside databases

Previous GC identifers: GC11M035294 GC11M034440 GC11M033801 GC11M033726 GC11M033719 GC11M033458

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO3:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,

the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs

(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3

classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different

protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs

class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99

Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In

the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act

synergically to activate p53/TP53-dependent transactivation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FBXO3 gene promoter:
TBP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBXO3 promoter sequence

Search SABiosciences Chromatin IP Primers for FBXO3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

FBXO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M033762: view genomic region (about GC identifiers)

Start:	33,762,485 bp from pter	End:	33,796,089 bp from pter
Size:	33,605 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99 (See protein sequence)

Recommended Name: F-box only protein 3

Size: 471 amino acids; 54561 Da

Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts

with PML, interaction is direct and takes place either alone or within the SCF complex

Subcellular location: Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies

Secondary accessions: B3KY16 D3DR05 Q86X90 Q9H0V2 Q9NUX2

Alternative splicing: 3 isoforms: Q9UK99-1 Q9UK99-2 Q9UK99-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO3: NX_Q9UK99

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UK99

FBXO3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_036307.2 NP_208385.1

ENSEMBL proteins:

ENSP00000435680 ENSP00000265651 ENSP00000433781 ENSP00000435165 ENSP00000434001

ENSP00000431745 ENSP00000408836 ENSP00000434099 ENSP00000431502

Reactome Protein details: Q9UK99
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FBXO3 OriGene Protein Over-expression Lysate: FBXO3 OriGene Custom Protein Services for FBXO3
	GenScript Custom Purified and Recombinant Proteins Services for FBXO3
	Novus Biologicals FBXO3 Proteins Novus Biologicals FBXO3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FBXO3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

FBXO3 for ontologies About GeneDecksing

FBXO3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for FBXO3
	GenScript Custom Superior Antibodies Services for FBXO3
	Novus Biologicals FBXO3 Antibodies
	Search for Antibodies for FBXO3 at Abcam
	Uscn Antibodies for FBXO3
	ThermoFisher Antibodies for FBXO3

Assay Products for FBXO3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FBXO3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FBXO3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FBXO3 for domains About GeneDecksing

3 InterPro domains/families:

IPR007474 ApaG_domain

IPR018958 Cell_wall_assmbl_KNR4-like

IPR001810 F-box_dom_cyclin-like

Graphical View of Domain Structure for InterPro Entry Q9UK99

ProtoNet protein and cluster: Q9UK99

1 Blocks protein family: IPB007474 Protein of unknown function DUF525

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99

Similarity: Contains 1 apaG domain

Similarity: Contains 1 F-box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99

Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In

the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act

synergically to activate p53/TP53-dependent transactivation

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FBXO3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO3 (see all 15):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3146 hsa-miR-449c* hsa-miR-16-1* hsa-miR-219-5p hsa-miR-340 hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: FBXO3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO3 (see all 7) OriGene shRNA RFP: FBXO3 OriGene siRNA: FBXO3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for FBXO3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FBXO3 (NM_033406)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FBXO3
		Search LifeMap BioReagents cell lines for FBXO3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	10531035
GO:0005515	protein binding	IPI	--

FBXO3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for FBXO3:

Increased cell death HMECs cel

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for FBXO3

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

FBXO3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FBXO3

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/18 Interacting proteins for FBXO3 (Q9UK99^{1, 3} ENSP00000265651⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKP1	P63208³, ENSP00000231487⁴	I2D: score=2 STRING: ENSP00000231487
RBX1	P62877³, ENSP00000216225⁴	I2D: score=1 STRING: ENSP00000216225
TNIP3	Q96KP6³, ENSP00000057513⁴	I2D: score=1 STRING: ENSP00000057513
TNFAIP3	P21580³, ENSP00000237289⁴	I2D: score=1 STRING: ENSP00000237289
BMPR1B	O00238³	I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	10531035
GO:0016567	protein ubiquitination	TAS	10531035

FBXO3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FBXO3
Search CenterWatch for drugs/clinical trials and news about FBXO3 / FBX3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FBXO3 gene (2 alternative transcripts):

NM_012175.3 NM_033406.2

Unigene Cluster for FBXO3:

F-box protein 3

Hs.406787 [show with all ESTs]

Unigene Representative Sequence: AB209039

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000526785(uc001muy.3) ENST00000265651(uc001muz.3) ENST00000530013(uc010rej.2 uc009ykb.3)

ENST00000530401 ENST00000531080 ENST00000532057 ENST00000534136 ENST00000527772

ENST00000448981(uc001mva.1 uc001mvb.1 uc010rek.1) ENST00000532927

ENST00000529137 ENST00000533103 ENST00000526952

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FBXO3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO3
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO3 (see all 15):
		hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3146 hsa-miR-449c* hsa-miR-16-1* hsa-miR-219-5p hsa-miR-340 hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: FBXO3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO3 (see all 7) OriGene shRNA RFP: FBXO3 OriGene siRNA: FBXO3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): FBXO3 (NM_033406)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FBXO3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO3

Additional cDNA sequence:

AB209039.1 AF174595.1 AF176702.1 AK001943.1 AK123198.1 AK126592.1 AK128454.1 AK300721.1

AK304866.1 AK316286.1 AL136625.1 AL162053.1 AL832826.1 BC017107.1 BC039291.1 BC046110.1

13 DOTS entries:

DT.113296 DT.95167441 DT.120743662 DT.100791026 DT.95167439 DT.92068892 DT.92437105 DT.100791020

DT.100008594 DT.100791023 DT.92437098 DT.99964935 DT.92437104

24/213 AceView cDNA sequences (see all 213):

AI702463 AI480330 AK128454 BM509064 W70091 BI759193 NM_012175 AF176702

BF222235 CA438477 BU159000 BF221555 BM723757 BQ008238 BM552179 AI480396

CK905375 AW510411 AA514201 AI675110 BM751273 AA002068 AI927646 BM682032

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO3 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c
SP1:					-																								-		-
SP2:					-														-										-		-
SP3:					-		-												-
SP4:					-														-
SP5:																			-										-		-

ECgene alternative splicing isoforms for FBXO3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBXO3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTTATGT

About this image

FBXO3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FBXO3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO3

SOURCE GeneReport for Unigene cluster: Hs.406787

SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO3:

Ubiquitination (Ubiquitylation) Pathway in human mouse rat

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FBXO3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for FBXO3 gene from 10/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fbxo3^{1 , 5}	F-box protein 3^{1, 5}	88.72(n)¹ 95.32(a)¹		2 (54.49 cM)⁵ 57443¹ NM_212433.1¹ NP_997598.1¹ 104027721⁵
chicken (Gallus gallus)	Aves	FBXO3¹	F-box protein 3	76.76(n) 80.85(a)		429495 XM_427051.3 XP_427051.3
lizard (Anolis carolinensis)	Reptilia	FBXO3⁶	--	76(a)	1 ↔ 1	GL343283.1(1007073-1025926)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1891²	Xenopus laevis transcribed sequence with weak similarity more	76.19(n)		BQ384336.1
zebrafish (Danio rerio)	Actinopterygii	fbxo3¹	F-box protein 3	68.88(n) 73.7(a)		553731 NM_001020702.1 NP_001018538.1
fruit fly (Drosophila melanogaster)	Insecta	CG12162⁶	--	13(a)	1 ↔ 1	3R(1293515-1295288)
worm (Caenorhabditis elegans)	Secernentea	tag-307⁶	Temporarily Assigned Gene name family member (tag-...	12(a)	1 ↔ 1	III(7855599-7857175)
thale cress (Arabidopsis thaliana)	eudicotyledons	SKIP16¹	F-box protein SKIP16	41.69(n) 26.39(a)		837120 NM_100492.3 NP_563759.1
rice (Oryza sativa)	Liliopsida	Os11g0265200¹	hypothetical protein	40.77(n) 28.23(a)		4350244 NM_001074190.2 NP_001067658.2
E. coli (Escherichia coli)	Gamma proteobacteria	apaG⁶	protein associated with Co2+ and Mg2+ efflux	35(a)	1 ↔ 1	Chromosome(51229-51606)

ENSEMBL Gene Tree for FBXO3 (if available)
TreeFam Gene Tree for FBXO3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FBXO3 gene

2 SIMAP similar genes for FBXO3 using alignment to 6 protein entries: FBX3_HUMAN (see all proteins):

FBX3 DKFZp586F1524

FBXO3 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for FBXO3
PGOHUM00000257946

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79586861^1,2	C,	--	33491936(+)	`TCCGCC/ACCCGT`	1	--	us2k¹		2		WA	120
rs1402957^1,2	C,F,	--	33491948(-)	`GACCGG/TGGCGA`	1	--	us2k¹		7		NA CSA WA EA	364
rs112686200^1,2		--	33492667(+)	`TCCCCG/ACCCCG`	1	--	us2k¹		1		CSA	1
rs1879756^1,2	F,H,	--	33493303(-)	`CACCAG/CAGGAG`	1	--	us2k¹ trp³		6		NS EA CSA WA	528
rs72920560^1,2		--	33493907(+)	`TGGGCA/CACCTG`	1	--	nc-transcript-variant		0	--	--	--	--
rs12291756^1,2	C,F,H,	--	33493980(+)	`CACTTG/CGACTT`	1	--	nc-transcript-variant		13		NS EA NA WA	1490
rs12277320^1,2	F,A,H,	--	33762050(+)	`atcacA/Gctacc`	1	--	ds500¹		5		NS EA WA	534
rs202234850^1,2		--	33762107(+)	`AAAAA-/AAAAG GATAG`	1	--	ds500¹		0	--	--	--	--
rs58698035^1,2	C,	--	33762108(+)	`AAAAA-/AAAG GATAG`	1	--	ds500¹		0	--	--	--	--
rs75364306^1,2	C	--	33762111(+)	`AAAAAG/AGATAG`	1	--	ds500¹		1		WA	2

HapMap Linkage Disequilibrium report for FBXO3 (33762485 - 33796089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBXO3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO3

DNA2.0 Custom Variant and Variant Library Synthesis for FBXO3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FBXO3 for disorders           About GeneDecksing

OMIM gene information: 609089    OMIM disorders: --

2 diseases for FBXO3:    About MalaCards

candidiasis tuberculosis

1 disease from the University of Copenhagen DISEASES database for FBXO3:

Candidiasis

Human Genome Epidemiology (HuGE) Navigator: FBXO3 (1 document)

Export disorders for FBXO3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FBXO3 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with FBXO3)

Utopia: connect your pdf to the dynamic
world of online information

A family of mammalian F-box proteins. (PubMed id 10531037)^{1, 2, 3} Winston J.T....Harper J.W. (1999)
PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PubMed id 18809579)^{1, 2, 9} Shima Y....Kitabayashi I. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26273	HGNC: 13582	AceView: FBXO3	Ensembl:ENSG00000110429	euGenes: HUgn26273
ECgene: FBXO3	H-InvDB: FBXO3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FBXO3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FBXO3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FBXO3 gene:
Search GeneIP for patents involving FBXO3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for FBXO3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO3
	OriGene Protein Over-expression Lysate for FBXO3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for FBXO3		OriGene 3'-UTR Clone for FBXO3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for FBXO3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for FBXO3		OriGene Custom Protein Services for FBXO3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO3

	GenScript Custom Purified and Recombinant Proteins Services for FBXO3		GenScript cDNA clones with any tag delivered in your preferred vector for FBXO3
	GenScript Custom Assay Services for FBXO3		GenScript Custom Superior Antibodies Services for FBXO3
	GenScript Custom overexpressing Cell Line Services for FBXO3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in FBXO3 promoter
	Search Chromatin IP Primers for FBXO3
	RT² qPCR Primer Assay in human, mouse, rat FBXO3
	Search GNC Networks for FBXO3
	SABiosciences PCR Arrays including human, mouse, rat FBXO3

Search Tocris compounds for FBXO3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	FBXO3 antibodies
	FBXO3 proteins
	FBXO3 lysates

	Search for Antibodies for FBXO3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for FBXO3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

FBXO3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for FBXO3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO3

	SwitchGear 3'UTR luciferase reporter plasmids for FBXO3
	SwitchGear Promoter luciferase reporter plasmids for FBXO3

ThermoFisher Antibodies for FBXO3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO3

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FBXO3 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

FBXO3 Gene

F-box protein 3

Aliases
for FBXO3 gene

Summaries
for FBXO3 gene

Genomic Views
for FBXO3 gene

Proteins
for FBXO3 gene

Protein Domains /
Families
for FBXO3 gene

Function
for FBXO3 gene

Pathways & Interactions
for FBXO3 gene

Drugs & Compounds
for FBXO3 gene

Transcripts
for FBXO3 gene

Expression
for FBXO3 gene

Orthologs
for FBXO3 gene

Paralogs
for FBXO3 gene

Genomic Variants
for FBXO3 gene

Disorders / Diseases
for FBXO3 gene

Publications
for FBXO3 gene

External Searches for FBXO3 gene

Genome Databases showing FBXO3 gene

Other Databases showing FBXO3 gene

Specialized Databases showing FBXO3 gene

Intellectual Property
for FBXO3 gene

Products
for FBXO3 gene

View Random Gene

Advanced Search

Export list of displayed genes

FBXO3 Gene

F-box protein 3

Aliasesfor FBXO3 gene

Summariesfor FBXO3 gene

Genomic Viewsfor FBXO3 gene

Proteinsfor FBXO3 gene

Protein Domains /Familiesfor FBXO3 gene

Functionfor FBXO3 gene

Pathways & Interactionsfor FBXO3 gene

Drugs & Compoundsfor FBXO3 gene

Transcriptsfor FBXO3 gene

Expression for FBXO3 gene

Orthologsfor FBXO3 gene

Paralogsfor FBXO3 gene

Genomic Variantsfor FBXO3 gene

Disorders / Diseasesfor FBXO3 gene

Publicationsfor FBXO3 gene

External Searches for FBXO3 gene

Genome Databases showing FBXO3 gene

Other Databases showing FBXO3 gene

Specialized Databases showing FBXO3 gene

Intellectual Propertyfor FBXO3 gene

Productsfor FBXO3 gene

View Random Gene

Aliases
for FBXO3 gene

Summaries
for FBXO3 gene

Genomic Views
for FBXO3 gene

Proteins
for FBXO3 gene

Protein Domains /
Families
for FBXO3 gene

Function
for FBXO3 gene

Pathways & Interactions
for FBXO3 gene

Drugs & Compounds
for FBXO3 gene

Transcripts
for FBXO3 gene

Expression
for FBXO3 gene

Orthologs
for FBXO3 gene

Paralogs
for FBXO3 gene

Genomic Variants
for FBXO3 gene

Disorders / Diseases
for FBXO3 gene

Publications
for FBXO3 gene

Intellectual Property
for FBXO3 gene

Products
for FBXO3 gene