Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXO3 Gene

Aliases for FBXO3 Gene

  • F-Box Protein 3 2 3 5
  • F-Box Only Protein 3 2 3
  • FBX3 3 4
  • F-Box Protein FBX3 3
  • FBA 3

External Ids for FBXO3 Gene

Previous GeneCards Identifiers for FBXO3 Gene

  • GC11M035294
  • GC11M034440
  • GC11M033801
  • GC11M033726
  • GC11M033719
  • GC11M033458

Summaries for FBXO3 Gene

Entrez Gene Summary for FBXO3 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO3 Gene

FBXO3 (F-Box Protein 3) is a Protein Coding gene. Diseases associated with FBXO3 include 3-Methylglutaconic Aciduria, Type Iii. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO3 Gene

  • Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Additional gene information for FBXO3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO3 Gene

Genomics for FBXO3 Gene

GeneHancer (GH) Regulatory Elements for FBXO3 Gene

Promoters and enhancers for FBXO3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I033773 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.2 213 1.9 SMAD1 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 ATF7 SP3 SP5 FBXO3-AS1 FBXO3 ENSG00000255272 CD59 LOC105376617 GC11M033731
GH11I033731 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.7 +39.4 39427 7.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YY1 POLR2B ZNF766 ZNF143 CD59 LOC105376617 FBXO3-AS1 KIAA1549L NAT10 FBXO3 ENSG00000255272 ENSG00000254619 GC11P033706 GC11M033731
GH11I033718 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.1 +52.3 52270 7.3 PKNOX1 ATF1 ARNT NEUROD1 SIN3A IRF4 BRCA1 GATA2 FOS RUNX3 CD59 FBXO3-AS1 LOC105376617 FBXO3 ENSG00000255272 RPS24P15 KIAA1549L C11orf91 TCP11L1 GC11P033706
GH11I033699 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 +70.8 70753 9.3 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS GC11M033703 C11orf91 CD59 CAPRIN1 RPS24P15 LOC105376617 FBXO3-AS1 FBXO3 GC11P033706
GH11I033802 Enhancer 1.1 Ensembl ENCODE 11.7 -28.0 -28008 1.1 PKNOX1 NEUROD1 SIN3A GLI4 ZNF2 GLIS2 ZNF213 KLF7 KLF13 SP3 PIR47137 FBXO3-AS1 FBXO3 ENSG00000255272 CD59 CSTF3 LOC646120 GC11M033731
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO3 gene promoter:

Genomic Locations for FBXO3 Gene

Genomic Locations for FBXO3 Gene
chr11:33,740,939-33,774,543
(GRCh38/hg38)
Size:
33,605 bases
Orientation:
Minus strand
chr11:33,762,485-33,796,089
(GRCh37/hg19)

Genomic View for FBXO3 Gene

Genes around FBXO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO3 Gene

Proteins for FBXO3 Gene

  • Protein details for FBXO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK99-FBX3_HUMAN
    Recommended name:
    F-box only protein 3
    Protein Accession:
    Q9UK99
    Secondary Accessions:
    • B3KY16
    • D3DR05
    • Q86X90
    • Q9H0V2
    • Q9NUX2

    Protein attributes for FBXO3 Gene

    Size:
    471 amino acids
    Molecular mass:
    54561 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex.

    Three dimensional structures from OCA and Proteopedia for FBXO3 Gene

    Alternative splice isoforms for FBXO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO3 Gene

Post-translational modifications for FBXO3 Gene

  • Ubiquitination at Lys218 and Lys390

No data available for DME Specific Peptides for FBXO3 Gene

Domains & Families for FBXO3 Gene

Gene Families for FBXO3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO3: view

No data available for UniProtKB/Swiss-Prot for FBXO3 Gene

Function for FBXO3 Gene

Molecular function for FBXO3 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

Phenotypes From GWAS Catalog for FBXO3 Gene

Gene Ontology (GO) - Molecular Function for FBXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FBXO3: view
genes like me logo Genes that share phenotypes with FBXO3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO3 Gene

Localization for FBXO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO3 Gene

Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO3 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with FBXO3: view

Pathways & Interactions for FBXO3 Gene

SuperPathways for FBXO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXO3: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO3 Gene

Drugs & Compounds for FBXO3 Gene

No Compound Related Data Available

Transcripts for FBXO3 Gene

Unigene Clusters for FBXO3 Gene

F-box protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -

Relevant External Links for FBXO3 Gene

GeneLoc Exon Structure for
FBXO3
ECgene alternative splicing isoforms for
FBXO3

Expression for FBXO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO3 Gene

This gene is overexpressed in Heart (12.1), Peripheral blood mononuclear cells (11.5), Placenta (7.2), and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO3 Gene



Protein tissue co-expression partners for FBXO3 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO3 Gene:

FBXO3

SOURCE GeneReport for Unigene cluster for FBXO3 Gene:

Hs.406787

Evidence on tissue expression from TISSUES for FBXO3 Gene

  • Nervous system(4.9)
  • Kidney(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with FBXO3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO3 Gene

Orthologs for FBXO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO3 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia FBXO3 33 34
  • 94.62 (n)
cow
(Bos Taurus)
Mammalia FBXO3 33 34
  • 91.97 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo3 33
  • 87.97 (n)
mouse
(Mus musculus)
Mammalia Fbxo3 33 16 34
  • 86.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO3 34
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO3 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO3 33 34
  • 78.13 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO3 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo3 33
  • 66.58 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1891 33
zebrafish
(Danio rerio)
Actinopterygii fbxo3 33 34
  • 68.66 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SKIP16 33
  • 41.86 (n)
rice
(Oryza sativa)
Liliopsida Os11g0265200 33
  • 40.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for FBXO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO3 Gene

ENSEMBL:
Gene Tree for FBXO3 (if available)
TreeFam:
Gene Tree for FBXO3 (if available)

Paralogs for FBXO3 Gene

(2) SIMAP similar genes for FBXO3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for FBXO3 Gene

genes like me logo Genes that share paralogs with FBXO3: view

No data available for Paralogs for FBXO3 Gene

Variants for FBXO3 Gene

Sequence variations from dbSNP and Humsavar for FBXO3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000005304 -- 33,769,984(-) T/G intron_variant
rs1000030172 -- 33,775,729(-) C/G upstream_transcript_variant
rs1000159511 -- 33,762,746(-) C/ intron_variant
rs1000302687 -- 33,755,044(-) T/C intron_variant
rs1000386894 -- 33,741,713(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO3 Gene

Variant ID Type Subtype PubMed ID
nsv523356 CNV loss 19592680
nsv832113 CNV gain 17160897

Variation tolerance for FBXO3 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO3 Gene

Disorders for FBXO3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
3-methylglutaconic aciduria, type iii
  • mgca3
- elite association - COSMIC cancer census association via MalaCards
Search FBXO3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FBXO3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FBXO3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO3 Gene

Publications for FBXO3 Gene

  1. PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PMID: 18809579) Shima Y … Kitabayashi I (Molecular and cellular biology 2008) 3 4 22 58
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for FBXO3 Gene

Sources for FBXO3 Gene

Content
Loading form....