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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO3 Gene

protein-coding   GIFtS: 57
GCID: GC11M033762

F-Box Protein 3

(Previous name: F-box only protein 3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 31 2
FBX32 3 5
F-Box Only Protein 31 2
FBA2 5
F-Box Protein FBX32

External Ids:    HGNC: 135821   Entrez Gene: 262732   Ensembl: ENSG000001104297   OMIM: 6090895   UniProtKB: Q9UK993   

Export aliases for FBXO3 gene to outside databases

Previous GC identifers: GC11M035294 GC11M034440 GC11M033801 GC11M033726 GC11M033719 GC11M033458


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO3 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging
at the 3' end. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO3 Gene: 
FBXO3 (F-box protein 3) is a protein-coding gene. Diseases associated with FBXO3 include candidiasis, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and protein binding.

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99
Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome.
In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may
act synergically to activate p53/TP53-dependent transactivation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO3 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

FBXO3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M033762:  view genomic region     (about GC identifiers)

Start:
33,762,485 bp from pter      End:
33,796,089 bp from pter
Size:
33,605 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99 (See protein sequence)
Recommended Name: F-box only protein 3  
Size: 471 amino acids; 54561 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1.
Interacts with PML, interaction is direct and takes place either alone or within the SCF complex
Subcellular location: Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies
Secondary accessions: B3KY16 D3DR05 Q86X90 Q9H0V2 Q9NUX2
Alternative splicing: 3 isoforms:  Q9UK99-1   Q9UK99-2   Q9UK99-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO3: NX_Q9UK99

Explore proteomics data for FBXO3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK99

  • FBXO3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036307.2  NP_208385.1  

    ENSEMBL proteins: 
     ENSP00000435680   ENSP00000265651   ENSP00000433781   ENSP00000435165   ENSP00000434001  
     ENSP00000431745   ENSP00000408836   ENSP00000434099   ENSP00000431502  
    Reactome Protein details: Q9UK99
    Human Recombinant Protein Products for FBXO3: 
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    Novus Biologicals FBXO3 Proteins
    Novus Biologicals FBXO3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    FBXO3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    3 InterPro protein domains:
     IPR007474 ApaG_domain
     IPR018958 Cell_wall_assmbl_KNR4-like
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9UK99

    ProtoNet protein and cluster: Q9UK99

    1 Blocks protein domain: IPB007474 Protein of unknown function DUF525

    UniProtKB/Swiss-Prot: FBX3_HUMAN, Q9UK99
    Similarity: Contains 1 apaG domain
    Similarity: Contains 1 F-box domain


    FBXO3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX3_HUMAN, Q9UK99
    Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
    Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome.
    In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may
    act synergically to activate p53/TP53-dependent transactivation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding IPI--
         
    FBXO3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO3:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO3 
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXO3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for FBXO3
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System



    FBXO3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/18 Interacting proteins for FBXO3 (Q9UK991, 3 ENSP000002656514) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
    TNIP3Q96KP63, ENSP000000575134I2D: score=1 STRING: ENSP00000057513
    TNFAIP3P215803, ENSP000002372894I2D: score=1 STRING: ENSP00000237289
    BMPR1BO002383I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10531035
    GO:0016567protein ubiquitination TAS10531035

    FBXO3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO3 (FBX3)

    Search CenterWatch for drugs/clinical trials and news about FBXO3 / FBX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO3 gene (2 alternative transcripts): 
    NM_012175.3  NM_033406.2  

    Unigene Cluster for FBXO3:

    F-box protein 3
    Hs.406787  [show with all ESTs]
    Unigene Representative Sequence: AB209039
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526785(uc001muy.3) ENST00000265651(uc001muz.3) ENST00000530013(uc010rej.2 uc009ykb.3)
    ENST00000530401 ENST00000531080 ENST00000532057 ENST00000534136 ENST00000527772
    ENST00000448981(uc001mva.1 uc001mvb.1 uc010rek.1) ENST00000532927
    ENST00000529137 ENST00000533103 ENST00000526952
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO3 (see all 15):
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-3146 hsa-miR-449c* hsa-miR-16-1* hsa-miR-219-5p hsa-miR-340 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFBXO3 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO3
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    Additional mRNA sequence: 

    AB209039.1 AF174595.1 AF176702.1 AK001943.1 AK123198.1 AK126592.1 AK128454.1 AK300721.1 
    AK304866.1 AK316286.1 AL136625.1 AL162053.1 AL832826.1 BC017107.1 BC039291.1 BC046110.1 

    13 DOTS entries:

    DT.113296  DT.95167441  DT.120743662  DT.100791026  DT.95167439  DT.92068892  DT.92437105  DT.100791020 
    DT.100008594  DT.100791023  DT.92437098  DT.99964935  DT.92437104 

    24/213 AceView cDNA sequences (see all 213):

    AA002068 BU159000 W70091 BQ008238 BM509064 AA514201 AI480330 AA644583 
    AK128454 BF221555 BM751273 BM785637 BF222235 BM682032 BQ787781 AW510411 
    BM552179 AI480396 BM729102 NM_012175 AI702463 AI675110 AI064809 CA391970 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c
    SP1:              -                                                                       -     -                     
    SP2:              -                                         -                             -     -                     
    SP3:              -     -                                   -                                                         
    SP4:              -                                         -                                                         
    SP5:                                                        -                             -     -                     


    ECgene alternative splicing isoforms for FBXO3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTATGT
    FBXO3 Expression
    About this image


    See FBXO3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO3

    SOURCE GeneReport for Unigene cluster: Hs.406787
        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FBXO3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo31 , 5 F-box protein 31, 5 88.72(n)1
    95.32(a)1
      2 (54.49 cM)5
    574431  NM_212433.11  NP_997598.11 
     1040277215 
    chicken
    (Gallus gallus)
    Aves FBXO31 F-box protein 3 76.76(n)
    80.85(a)
      429495  XM_427051.3  XP_427051.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO36
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343283.1(1007073-1025926)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.18912 Xenopus laevis transcribed sequence with weak similarity more 76.19(n)    BQ384336.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo31 F-box protein 3 68.88(n)
    73.7(a)
      553731  NM_001020702.1  NP_001018538.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SKIP161 F-box protein SKIP16 41.69(n)
    26.39(a)
      837120  NM_100492.3  NP_563759.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g02652001 hypothetical protein 40.77(n)
    28.23(a)
      4350244  NM_001074190.2  NP_001067658.2 


    ENSEMBL Gene Tree for FBXO3 (if available)
    TreeFam Gene Tree for FBXO3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO3 gene
    2 SIMAP similar genes for FBXO3 using alignment to 6 protein entries:     FBX3_HUMAN (see all proteins):
    FBX3    DKFZp586F1524

    FBXO3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FBXO3
    PGOHUM00000257946


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/633 SNPs in FBXO3 are shown (see all 633)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs122773201,2
    C,F,A,H--33762050(+) atcacA/Gctacc 1 -- ds50015Minor allele frequency- G:0.04NS EA WA 534
    rs2022348501,2
    --33762107(+) AAAAA-/AAAAG 
            
    GATAG
    1 -- ds50010--------
    rs586980351,2
    C--33762108(+) AAAAA-/AAAG  
            
    GATAG
    1 -- ds50010--------
    rs608366871,2
    C--33762110(+) AAAAA-/AAAA  
     
    /AAAAAA
    GGATA
    2 -- ds5001 cds11NA 2
    rs753643061,2
    C--33762111(+) AAAAAG/AGATAG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1818581791,2
    --33762377(+) TGAGTA/GGACCT 1 -- ds50010--------
    rs1864213491,2
    --33762427(+) TCTACC/TTTAAA 1 -- ds50010--------
    rs1904259461,2
    --33762463(+) ATGGAA/TAATAA 1 -- ds50010--------
    rs1482197421,2
    --33762470(+) ATAAGC/TAATTA 1 -- ds50010--------
    rs1822695191,2
    --33762585(+) CAAGTG/TTCAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXO3 (33762485 - 33796089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXO3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523356CNV Loss19592680
    nsv832113CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609089    OMIM disorders: --

    2 diseases for FBXO3:    About MalaCards
    candidiasis    

    1 disease from the University of Copenhagen DISEASES database for FBXO3:
    Candidiasis

    FBXO3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO3
    Human Genome Epidemiology (HuGE) Navigator: FBXO3 (1 document)

    Export disorders for FBXO3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with FBXO3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
    2. PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PubMed id 18809579)1, 2, 9 Shima Y....Kitabayashi I. (2008)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. A combinatorial F box protein directed pathway control s TRAF adaptor stability to regulate inflammation. (PubMed id 23542741)1 Chen B.B....Mallampalli R.K. (2013)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    8. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26273 HGNC: 13582 AceView: FBXO3 Ensembl:ENSG00000110429 euGenes: HUgn26273
    ECgene: FBXO3 H-InvDB: FBXO3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO3 gene:
    Search GeneIP for patents involving FBXO3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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