Aliases for FBXO28 Gene
Aliases for FBXO28 Gene
External Ids for FBXO28 Gene
- HGNC: 29046
- Entrez Gene: 23219
- Ensembl: ENSG00000143756
- OMIM: 609100
- UniProtKB: Q9NVF7
Previous GeneCards Identifiers for FBXO28 Gene
- GC01P221277
- GC01P220608
- GC01P222368
- GC01P224302
- GC01P194822
Summaries for FBXO28 Gene
-
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO28 Gene
FBXO28 (F-Box Protein 28) is a Protein Coding gene. Diseases associated with FBXO28 include Chromosome 1Q41-Q42 Deletion Syndrome and Chromosomal Deletion Syndrome.
UniProtKB/Swiss-Prot for FBXO28 Gene
-
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO28 Gene
Genomics for FBXO28 Gene
Regulatory Elements for FBXO28 Gene
Enhancers for FBXO28 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO28 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO28 gene promoter:
Regulatory Element Products
Genomic Location for FBXO28 Gene
- Chromosome:
- 1
- Start:
- 224,114,087 bp from pter
- End:
- 224,162,047 bp from pter
- Size:
- 47,961 bases
- Orientation:
- Plus strand
Genomic View for FBXO28 Gene
Genes around FBXO28 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.11 by Ensembl
- 1q42.11 by Entrez Gene
- 1q42.11 by HGNC
FBXO28 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO28 Gene
Proteins for FBXO28 Gene
-
Protein details for FBXO28 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NVF7-FBX28_HUMAN
- Recommended name:
- F-box only protein 28
- Protein Accession:
- Q9NVF7
- E9PEM8
- O75070
Protein attributes for FBXO28 Gene
- Size:
- 368 amino acids
- Molecular mass:
- 41149 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
Protein Expression for FBXO28 Gene
Post-translational modifications for FBXO28 Gene
Other Protein References for FBXO28 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXO28
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- antibodies-online Antibodies for FBXO28: See all 29
- GeneTex FBXO28 antibody for FBXO28
-
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Protein Products
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- antibodies-online Proteins for FBXO28: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO28
Assay Products
- antibodies-online Kits for FBXO28: See all 15
No data available for DME Specific Peptides for FBXO28 Gene
Domains & Families for FBXO28 Gene
Gene Families for FBXO28 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FBXO28 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO28 Gene
Function for FBXO28 Gene
Molecular function for FBXO28 Gene
- UniProtKB/Swiss-Prot Function:
- Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for FBXO28 Gene
- GenomeRNAi human phenotypes for FBXO28:
Animal Model Products
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-
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CRISPR Products
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miRNA for FBXO28 Gene
- miRTarBase miRNAs that target FBXO28
-
- hsa-mir-148b-3p (MIRT019382)
- hsa-mir-130b-3p (MIRT020240)
- hsa-mir-132-3p (MIRT021854)
- hsa-mir-221-3p (MIRT024194)
- hsa-mir-181a-5p (MIRT025097)
- hsa-mir-32-5p (MIRT028351)
- hsa-mir-26b-5p (MIRT029652)
- hsa-mir-19b-3p (MIRT031172)
- hsa-mir-615-3p (MIRT039604)
- hsa-mir-17-5p (MIRT050792)
- hsa-mir-448 (MIRT063575)
- hsa-mir-297 (MIRT063577)
- hsa-mir-3924 (MIRT063579)
- hsa-mir-19a-3p (MIRT063592)
- hsa-mir-208a-5p (MIRT063594)
- hsa-mir-130a-3p (MIRT063595)
- hsa-mir-9-3p (MIRT063596)
- hsa-mir-320a (MIRT063597)
- hsa-mir-301a-3p (MIRT063598)
- hsa-mir-504-3p (MIRT063599)
- hsa-mir-320b (MIRT063600)
- hsa-mir-320c (MIRT063601)
- hsa-mir-454-3p (MIRT063602)
- hsa-mir-301b-3p (MIRT063603)
- hsa-mir-208b-5p (MIRT063604)
- hsa-mir-320d (MIRT063605)
- hsa-mir-3140-3p (MIRT063606)
- hsa-mir-4295 (MIRT063607)
- hsa-mir-3666 (MIRT063609)
- hsa-mir-4429 (MIRT063610)
- hsa-mir-4698 (MIRT063611)
- hsa-mir-4433b-3p (MIRT063612)
- hsa-mir-8063 (MIRT063613)
- hsa-mir-210-5p (MIRT063620)
- hsa-mir-3607-3p (MIRT063624)
- hsa-mir-3976 (MIRT063626)
- hsa-mir-5000-5p (MIRT063627)
- hsa-mir-6769a-3p (MIRT063628)
- hsa-mir-885-5p (MIRT063634)
- hsa-mir-660-5p (MIRT271480)
- hsa-mir-5591-3p (MIRT271481)
- hsa-mir-455-5p (MIRT336316)
- hsa-mir-759 (MIRT548251)
- hsa-mir-616-5p (MIRT548252)
- hsa-mir-373-5p (MIRT548253)
- hsa-mir-371b-5p (MIRT548254)
- hsa-mir-567 (MIRT548255)
- hsa-mir-298 (MIRT548256)
- hsa-mir-3910 (MIRT557912)
- hsa-mir-3714 (MIRT557913)
- hsa-mir-606 (MIRT557914)
- hsa-mir-124-3p (MIRT557915)
- hsa-mir-506-3p (MIRT557916)
- hsa-mir-3682-5p (MIRT557917)
- hsa-mir-3688-3p (MIRT557918)
- hsa-mir-8084 (MIRT557919)
miRNA Products
- Search ViGene Biosciences for FBXO28
Inhibitory RNA Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO28 Gene
Localization for FBXO28 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXO28 Gene
- Chromosome, centromere, kinetochore.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| plasma membrane | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IEA,IDA | 20813266 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for FBXO28 Gene
No Data Available
Interacting Proteins for FBXO28 Gene
Selected Interacting proteins:
Q9NVF7-FBX28_HUMAN
ENSP00000355827
for FBXO28 Gene via
IID
UniProtKB
STRING
MINT
No data available for Pathways by source and SIGNOR curated interactions for FBXO28 Gene
Transcripts for FBXO28 Gene
mRNA/cDNA for FBXO28 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (215) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO28
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO28
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miRNA Products
- Search ViGene Biosciences for FBXO28
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO28 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | - | ||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: |
Expression for FBXO28 Gene
This gene is overexpressed in Bone marrow mesenchymal stem cell (49.3) and Urine (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO28 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO28 Gene:
FBXO28SOURCE GeneReport for Unigene cluster for FBXO28 Gene:
Hs.64691Evidence on tissue expression from TISSUES for FBXO28 Gene
- Nervous system(4.7)
- Intestine(4.4)
- Gall bladder(2.2)
- Heart(2.2)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXO28
-
OriGene qPCR primer pairs for FBXO28
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO28 Gene
Orthologs for FBXO28 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO28 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | FBXO28 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO28 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fbxo28 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo28 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO28 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | FBXO28 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO28 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo28 34 |
|
||
| Str.16184 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.13216 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo28 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | pall 35 |
|
OneToMany | |
| CG11866 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXO28 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO28 Gene
No data available for Paralogs for FBXO28 Gene
Variants for FBXO28 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000075759 | -- | 224,137,754(+) | TGTGA(C/G)AGTGG | intron-variant | |
| rs1000080002 | -- | 224,156,525(+) | CTGCA(C/T)AATCT | intron-variant | |
| rs1000200331 | -- | 224,113,526(+) | TCACC(A/C)ATTAG | upstream-variant-2KB | |
| rs1000215925 | -- | 224,148,187(+) | GATAA(C/T)ATTTC | intron-variant | |
| rs1000216723 | -- | 224,120,016(+) | CAAAA(C/T)AACTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2663158 | CNV | deletion | 23128226 |
| esv2759000 | CNV | gain+loss | 17122850 |
| esv3588968 | CNV | loss | 21293372 |
| esv3588969 | CNV | loss | 21293372 |
| nsv1133942 | CNV | deletion | 24896259 |
| nsv1133943 | CNV | deletion | 24896259 |
| nsv832692 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.93;
19.25% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO28 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO28 Gene
Disorders for FBXO28 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 1q41-q42 deletion syndrome |
|
|
| chromosomal deletion syndrome |
|
|
Search FBXO28 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FBXO28
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXO28
No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO28 Gene
Publications for FBXO28 Gene
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 64
- The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for FBXO28 Gene
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- Yeast expression
Sources for FBXO28 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (136) ViGene Biosciences
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer