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FBXO28 Gene

protein-coding   GIFtS: 51
GCID: GC01P224302

F-Box Protein 28

  Search for FBXO28
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 281 2     Fbx282
Centromere Protein 301 2     F-Box Only Protein 282
KIAA04833 5     FBX285
CENP-302     

External Ids:    HGNC: 290461   Entrez Gene: 232192   Ensembl: ENSG000001437567   OMIM: 6091005   UniProtKB: Q9NVF73   

Export aliases for FBXO28 gene to outside databases

Previous GC identifers: GC01P221277 GC01P220608 GC01P222368 GC01P194822


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO28 Gene:
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXO28 Gene:
FBXO28 (F-box protein 28) is a protein-coding gene.

UniProtKB/Swiss-Prot: FBX28_HUMAN, Q9NVF7
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
degradation (By similarity)

Gene Wiki entry for FBXO28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO28 gene promoter:
         Tal-1   HSF1 (long)   HNF-3beta   GATA-2   E47   Evi-1   FOXL1   S8   SRY   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO28 promoter sequence
   Search Chromatin IP Primers for FBXO28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.11   Ensembl cytogenetic band:  1q42.11   HGNC cytogenetic band: 1q42.12

FBXO28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO28 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P224302:  view genomic region     (about GC identifiers)

Start:
224,301,789 bp from pter      End:
224,349,749 bp from pter
Size:
47,961 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX28_HUMAN, Q9NVF7 (See protein sequence)
Recommended Name: F-box only protein 28  
Size: 368 amino acids; 41149 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Secondary accessions: E9PEM8 O75070
Alternative splicing: 2 isoforms:  Q9NVF7-1   Q9NVF7-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FBXO28: NX_Q9NVF7

Explore proteomics data for FBXO28 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys269
  • Modification sites at PhosphoSitePlus

  • See FBXO28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129587.1  NP_055991.1  

    ENSEMBL proteins: 
     ENSP00000355827   ENSP00000416888   ENSP00000430632  

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    Cloud-Clone Corp. CLIAs for FBXO28


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9NVF7

    ProtoNet protein and cluster: Q9NVF7

    UniProtKB/Swiss-Prot: FBX28_HUMAN, Q9NVF7
    Similarity: Contains 1 F-box domain


    FBXO28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX28_HUMAN, Q9NVF7
    Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
    degradation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FBXO28 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXO28:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO28
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    miRNA
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    miRTarBase miRNAs that target FBXO28:
    hsa-mir-19b-3p (MIRT031172), hsa-mir-32-5p (MIRT028351), hsa-mir-130b-3p (MIRT020240), hsa-mir-615-3p (MIRT039604), hsa-mir-132-3p (MIRT021854), hsa-mir-26b-5p (MIRT029652), hsa-mir-17-5p (MIRT050792), hsa-mir-148b-3p (MIRT019382), hsa-mir-221-3p (MIRT024194), hsa-mir-181a-5p (MIRT025097)

    Block miRNA regulation of human, mouse, rat FBXO28 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO28 (see all 117):
    hsa-miR-579 hsa-miR-146a hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p hsa-miR-30d hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFBXO28 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    plasma membrane2
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO28
    Interactions:

        Search GeneGlobe Interaction Network for FBXO28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for FBXO28 (Q9NVF72, 3 ENSP000003558274) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF2Q129333, ENSP000002476684I2D: score=6 STRING: ENSP00000247668
    GOLGA2Q083793I2D: score=1 
    NINLQ9Y2I63I2D: score=1 
    PAK1Q131533I2D: score=1 
    SKP1ENSP000002314874STRING: ENSP00000231487
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO28 (FBX28)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXO28 gene (2 alternative transcripts): 
    NM_001136115.2  NM_015176.3  

    Unigene Cluster for FBXO28:

    F-box protein 28
    Hs.64691  [show with all ESTs]
    Unigene Representative Sequence: NM_015176
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366862(uc001hoh.2 uc009xef.2 uc010pvc.1) ENST00000424254
    ENST00000523990 ENST00000483773 ENST00000519894
    miRNA
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    Block miRNA regulation of human, mouse, rat FBXO28 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO28 (see all 117):
    hsa-miR-579 hsa-miR-146a hsa-miR-106a hsa-miR-4272 hsa-miR-199a-3p hsa-miR-30d hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidFBXO28 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO28
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO28
      QuantiFast Probe-based Assays in human, mouse, rat FBXO28

    Additional mRNA sequence: 

    AB007952.1 AK001628.1 AK303381.1 AK307892.1 BC014378.1 BC031576.1 NR_049764.1 U38437.1 

    5 DOTS entries:

    DT.212212  DT.75162623  DT.92050009  DT.121386479  DT.121386532 

    Selected AceView cDNA sequences (see all 215):

    AW160955 AU132580 BF508425 AA112558 BU542133 Z43518 BE888531 BX431735 
    AI272187 AU131944 BQ066854 BM459498 AW236476 CB241653 BC031576 W74686 
    BM805149 CR607640 AI628103 C01423 AL700672 AA355792 AW419175 AA629973 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO28    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                    -           -                     
    SP2:                    -           -     -               
    SP3:                    -                                 
    SP4:                                                      


    ECgene alternative splicing isoforms for FBXO28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGTTGGG
    FBXO28 Expression
    About this image

    FBXO28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.64691
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXO28 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo281 , 5 F-box protein 281, 5 90.26(n)1
    97.54(a)1
      1 (84.93 cM)5
    679481  NM_175127.21  NP_780336.11 
     1823131025 
    chicken
    (Gallus gallus)
    Aves FBXO281 F-box protein 28 81.94(n)
    91.33(a)
      421328  XM_419393.4  XP_419393.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO286
    F-box protein 28
    92(a)
    1 ↔ 1
    1(252830628-252831023)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132162 Xenopus laevis transcribed sequence with moderate similarity more 77.71(n)    BX854965.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo281 F-box protein 28 67.61(n)
    76.1(a)
      556288  XM_679052.6  XP_684144.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta pall6
    CG118666
    --
    34(a)
    18(a)
    many → 1
    many → 1
    3L(9479548-9480890)
    2R(6005199-6008956)


    ENSEMBL Gene Tree for FBXO28 (if available)
    TreeFam Gene Tree for FBXO28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO28 (see all 1200)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339755171,2
    C--194850533(+) TTAAA-/T/TT  
            
    TTTTT
    3 -- int11CSA 2
    rs598194761,2
    C,F--224299805(+) TCAAGG/TGTTGC 3 -- us2k13Minor allele frequency- T:0.21WA CSA 122
    rs725118901,2
    C--224299871(+) GTGTA-/A/TAAATA 3 -- us2k10--------
    rs1491303731,2
    C--224299874(+) GTAAA-/TATACA 3 -- us2k10--------
    rs1150670941,2
    C,F--224299884(+) AAAGCA/GTGCGG 3 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1395960091,2
    --224299888(+) CATGCA/GGCCGG 3 -- us2k10--------
    rs1450052041,2
    --224299896(+) CGGGCA/GCCATT 3 -- us2k10--------
    rs64261201,2
    C,F--224299899(+) gcgccG/Attgct 3 -- us2k113Minor allele frequency- A:0.03NA WA CSA EA 377
    rs1475750511,2
    C--224299919(+) CCCAGA/CACTTT 3 -- us2k10--------
    rs1815060391,2
    --224299936(+) CTGAGA/GTGGGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO28 (224301789 - 224349749 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FBXO28:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663158CNV Deletion23128226
    nsv873222CNV Loss21882294
    nsv832692CNV Gain17160897
    essv6404CNV CNV17122850
    dgv182e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO28
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609100    OMIM disorders: --


    FBXO28 for disorders           About GeneDecksing


    Export disorders for FBXO28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO28 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with FBXO28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (DNA Res. 1997)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer. (PubMed id 23776131)1 Cepeda D....Sangfelt O. (EMBO Mol Med 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23219 HGNC: 29046 AceView: FBXO28 Ensembl:ENSG00000143756 euGenes: HUgn23219
    ECgene: FBXO28 H-InvDB: FBXO28

    (According to HUGE)
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    HUGE: KIAA0483

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO28 gene:
    Search GeneIP for patents involving FBXO28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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