FBXO28 Gene
protein-coding GIFtS: 47
GCID: GC01P224302
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|
F-box protein 28
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Aliases
for FBXO28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box Protein 281 2 | | FLJ107661 | | KIAA04831 3 5 | | Centromere Protein 302 | | CENP-301 2 | | F-Box Only Protein 282 | | Fbx281 2 | | FBX285 |
Export aliases for FBXO28 gene to outside databasesPrevious GC identifers: GC01P221277 GC01P220608 GC01P222368 GC01P194822 |
Summaries
for FBXO28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXO28:
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FBX28_HUMAN, Q9NVF7Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination anddegradation (By similarity)
Gene Wiki entry for FBXO28
|
Genomic Views
for FBXO28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXO28 gene promoter:
Tal-1 HSF1 (long) HNF-3beta GATA-2 E47 Evi-1 FOXL1 S8 SRY HSF1short
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.11 Ensembl cytogenetic band: 1q42.11 HGNC cytogenetic band: 1q42.12FBXO28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P224302: view genomic region
(about GC identifiers)
Start:
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224,301,789 bp from pter |
End:
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224,349,749 bp from pter |
Size:
|
47,961 bases |
Orientation:
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plus strand |
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Proteins
for FBXO28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBX28_HUMAN, Q9NVF7 (See
protein sequence)Recommended Name: F-box only protein 28 Size: 368 amino acids; 41149 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Secondary accessions: O75070Explore the universe of human proteins at neXtProt for FBXO28: NX_Q9NVF7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NVF7
FBXO28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001129587.1 NP_055991.1
ENSEMBL proteins: ENSP00000355827 ENSP00000416888 ENSP00000430632
Human Recombinant Protein Products for FBXO28:
FBXO28 Antibody Products:
Assay Products for FBXO28: |
Protein
Domains /
Families
for FBXO28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO28 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NVF7ProtoNet protein and cluster: Q9NVF7 UniProtKB/Swiss-Prot: FBX28_HUMAN, Q9NVF7Similarity: Contains 1 F-box domain |
Function
for FBXO28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FBX28_HUMAN, Q9NVF7Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination anddegradation (By similarity)Phenotypes:
2 GenomeRNAi human phenotypes for FBXO28:
Animal Models:
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO28 |
|
Pathways & Interactions
for FBXO28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO28
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/9 Interacting proteins for FBXO28 (Q9NVF72, 3 ENSP000003558274) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for FBXO28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXO28
Search CenterWatch for drugs/clinical trials and news about FBXO28 / FBX28
|
Transcripts
for FBXO28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXO28 gene (2 alternative transcripts): NM_001136115.2 NM_015176.3 Unigene Cluster for FBXO28: F-box protein 28 Hs.64691 [show with all ESTs]Unigene Representative Sequence: NM_0151765 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366862(uc001hoh.2 uc009xef.2 uc010pvc.1) ENST00000424254
ENST00000523990 ENST00000483773 ENST00000519894
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO28 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO28 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FBXO28 (NM_001136115) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO28 |
Additional cDNA sequence: AB007952.1 AK001628.1 AK303381.1 AK307892.1 BC014378.1 BC031576.1 NR_049764.1 U38437.1 5 DOTS entries: DT.212212 DT.75162623 DT.92050009 DT.121386479 DT.121386532 24/215 AceView cDNA sequences (see all 215): AW419175 BX431735 AW236476 CR607640 CB241653 BM805149 BC031576 AA926745 AI682809 AA355792 AL700672 CR607611 AU130799 AI418343 AI690717 AA629973 AI272187 AU131944 AW160955 Z43518 BF508425 BM797262 BE888531 AU132580
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO28 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXO28
|
Expression
for FBXO28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTGTTGGG
About this image
See FBXO28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO28
SOURCE GeneReport for Unigene cluster: Hs.64691
SABiosciences Custom PCR Arrays for FBXO28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO28
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO28 |
Orthologs
for FBXO28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXO28 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for FBXO28 (if available)
TreeFam Gene Tree for FBXO28 (if available) |
Paralogs
for FBXO28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FBXO28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO28 (224301789 - 224349749 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FBXO28
2 CNVs: 84869 3331 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO28 |
|
Disorders
/ Diseases
for FBXO28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FBXO28 for disorders About MalaCards
FBXO28 for disorders About GeneDecksing
OMIM gene information: 609100
OMIM disorders: --
Export disorders for FBXO28 gene to outside databases
|
Publications
for FBXO28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO28 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with FBXO28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for FBXO28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXO28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO28 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FBXO28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXO28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXO28 gene:
Search GeneIP for patents involving FBXO28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXO28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO28 |
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