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Aliases for FBXO28 Gene

Aliases for FBXO28 Gene

  • F-Box Protein 28 2 3 5
  • Centromere Protein 30 2 3
  • CENP-30 3 4
  • F-Box Only Protein 28 3
  • KIAA0483 4
  • Fbx28 3

External Ids for FBXO28 Gene

Previous GeneCards Identifiers for FBXO28 Gene

  • GC01P221277
  • GC01P220608
  • GC01P222368
  • GC01P224302
  • GC01P194822

Summaries for FBXO28 Gene

Entrez Gene Summary for FBXO28 Gene

  • Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO28 Gene

FBXO28 (F-Box Protein 28) is a Protein Coding gene. Diseases associated with FBXO28 include Chromosome 1Q41-Q42 Deletion Syndrome.

UniProtKB/Swiss-Prot for FBXO28 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Wiki entry for FBXO28 Gene

Additional gene information for FBXO28 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO28 Gene

Genomics for FBXO28 Gene

Regulatory Elements for FBXO28 Gene

Enhancers for FBXO28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H223844 1.7 FANTOM5 ENCODE dbSUPER 21.7 -268.3 -268335 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CICP5 NVL LOC100287497 CAPN2 FBXO28 TP53BP2 WDR26 CNIH4 GTF2IP20 GC01M223821
GH01H223710 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -397.8 -397764 11 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF766 NVL CICP5 LOC100287497 CAPN2 TP53BP2 WDR26 CAPN8 GTF2IP20 FBXO28 RNU6-1248P
GH01H223704 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -407.0 -407035 5 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS CICP5 CAPN2 LOC100287497 NVL WDR26 CNIH4 CAPN8 FBXO28 AIDA DISP1
GH01H224202 1.5 Ensembl ENCODE dbSUPER 11.8 +90.7 90725 3 PKNOX1 ATF1 FEZF1 ZNF2 ZNF121 GLIS2 GATA2 FOS ATF7 RUNX3 LOC101927143 FBXO28 LOC100287497 CICP5 CNIH4 CAPN2 DEGS1 PIR34911
GH01H224561 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +449.8 449779 4 CTCF JUN MAX CEBPG ZIC2 FOSL1 GATA3 POLR2A ZNF416 FOSL2 NVL FBXO28 AKR1B1P1 GC01P224480
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO28 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020839 513 2001 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2

Genomic Location for FBXO28 Gene

Chromosome:
1
Start:
224,114,087 bp from pter
End:
224,162,047 bp from pter
Size:
47,961 bases
Orientation:
Plus strand

Genomic View for FBXO28 Gene

Genes around FBXO28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO28 Gene

Proteins for FBXO28 Gene

  • Protein details for FBXO28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVF7-FBX28_HUMAN
    Recommended name:
    F-box only protein 28
    Protein Accession:
    Q9NVF7
    Secondary Accessions:
    • E9PEM8
    • O75070

    Protein attributes for FBXO28 Gene

    Size:
    368 amino acids
    Molecular mass:
    41149 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

    Alternative splice isoforms for FBXO28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO28 Gene

Post-translational modifications for FBXO28 Gene

  • Ubiquitination at posLast=269269
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO28 Gene

No data available for DME Specific Peptides for FBXO28 Gene

Domains & Families for FBXO28 Gene

Gene Families for FBXO28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FBXO28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO28: view

No data available for UniProtKB/Swiss-Prot for FBXO28 Gene

Function for FBXO28 Gene

Molecular function for FBXO28 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Phenotypes From GWAS Catalog for FBXO28 Gene

Gene Ontology (GO) - Molecular Function for FBXO28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FBXO28: view
genes like me logo Genes that share phenotypes with FBXO28: view

Animal Model Products

CRISPR Products

miRNA for FBXO28 Gene

miRTarBase miRNAs that target FBXO28

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO28
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO28 Gene

Localization for FBXO28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO28 Gene

Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO28 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXO28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA,IEA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with FBXO28: view

Pathways & Interactions for FBXO28 Gene

SuperPathways for FBXO28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO28 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO28 Gene

Drugs & Compounds for FBXO28 Gene

No Compound Related Data Available

Transcripts for FBXO28 Gene

Unigene Clusters for FBXO28 Gene

F-box protein 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO28
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for FBXO28 Gene

GeneLoc Exon Structure for
FBXO28
ECgene alternative splicing isoforms for
FBXO28

Expression for FBXO28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO28 Gene

Protein differential expression in normal tissues from HIPED for FBXO28 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.3) and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO28 Gene



Protein tissue co-expression partners for FBXO28 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO28 Gene:

FBXO28

SOURCE GeneReport for Unigene cluster for FBXO28 Gene:

Hs.64691

Evidence on tissue expression from TISSUES for FBXO28 Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Gall bladder(2.2)
  • Heart(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with FBXO28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO28 Gene

Orthologs for FBXO28 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO28 33 34
  • 99.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FBXO28 33 34
  • 94.2 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO28 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo28 33
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Fbxo28 33 16 34
  • 90.26 (n)
dog
(Canis familiaris)
Mammalia FBXO28 33 34
  • 89.67 (n)
chicken
(Gallus gallus)
Aves FBXO28 33 34
  • 81.94 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO28 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo28 33
  • 74.39 (n)
Str.16184 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13216 33
zebrafish
(Danio rerio)
Actinopterygii fbxo28 33 34
  • 67.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta pall 34
  • 34 (a)
OneToMany
CG11866 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToOne
Species where no ortholog for FBXO28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO28 Gene

ENSEMBL:
Gene Tree for FBXO28 (if available)
TreeFam:
Gene Tree for FBXO28 (if available)

Paralogs for FBXO28 Gene

No data available for Paralogs for FBXO28 Gene

Variants for FBXO28 Gene

Sequence variations from dbSNP and Humsavar for FBXO28 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000075759 -- 224,137,754(+) TGTGA(C/G)AGTGG intron-variant
rs1000080002 -- 224,156,525(+) CTGCA(C/T)AATCT intron-variant
rs1000200331 -- 224,113,526(+) TCACC(A/C)ATTAG upstream-variant-2KB
rs1000215925 -- 224,148,187(+) GATAA(C/T)ATTTC intron-variant
rs1000216723 -- 224,120,016(+) CAAAA(C/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO28 Gene

Variant ID Type Subtype PubMed ID
esv2663158 CNV deletion 23128226
esv2759000 CNV gain+loss 17122850
esv3588968 CNV loss 21293372
esv3588969 CNV loss 21293372
nsv1133942 CNV deletion 24896259
nsv1133943 CNV deletion 24896259
nsv832692 CNV gain 17160897

Variation tolerance for FBXO28 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO28 Gene

Human Gene Mutation Database (HGMD)
FBXO28
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO28 Gene

Disorders for FBXO28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO28 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
chromosome 1q41-q42 deletion syndrome
  • 1q41-q42 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO28
genes like me logo Genes that share disorders with FBXO28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO28 Gene

Publications for FBXO28 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 60
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for FBXO28 Gene

Sources for FBXO28 Gene

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