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Aliases for FBXO28 Gene

Aliases for FBXO28 Gene

  • F-Box Protein 28 2 3 5
  • Centromere Protein 30 2 3
  • CENP-30 3 4
  • F-Box Only Protein 28 3
  • KIAA0483 4
  • Fbx28 3

External Ids for FBXO28 Gene

Previous GeneCards Identifiers for FBXO28 Gene

  • GC01P221277
  • GC01P220608
  • GC01P222368
  • GC01P224302
  • GC01P194822

Summaries for FBXO28 Gene

Entrez Gene Summary for FBXO28 Gene

  • Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO28 Gene

FBXO28 (F-Box Protein 28) is a Protein Coding gene. Diseases associated with FBXO28 include Chromosome 1Q41-Q42 Deletion Syndrome.

UniProtKB/Swiss-Prot for FBXO28 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Wiki entry for FBXO28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO28 Gene

Genomics for FBXO28 Gene

Regulatory Elements for FBXO28 Gene

Enhancers for FBXO28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FBXO28 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FBXO28 Gene

Chromosome:
1
Start:
224,114,087 bp from pter
End:
224,162,047 bp from pter
Size:
47,961 bases
Orientation:
Plus strand

Genomic View for FBXO28 Gene

Genes around FBXO28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO28 Gene

Proteins for FBXO28 Gene

  • Protein details for FBXO28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVF7-FBX28_HUMAN
    Recommended name:
    F-box only protein 28
    Protein Accession:
    Q9NVF7
    Secondary Accessions:
    • E9PEM8
    • O75070

    Protein attributes for FBXO28 Gene

    Size:
    368 amino acids
    Molecular mass:
    41149 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

    Alternative splice isoforms for FBXO28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO28 Gene

Post-translational modifications for FBXO28 Gene

  • Ubiquitination at Lys 269
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO28 Gene

No data available for DME Specific Peptides for FBXO28 Gene

Domains & Families for FBXO28 Gene

Gene Families for FBXO28 Gene

Protein Domains for FBXO28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVF7

UniProtKB/Swiss-Prot:

FBX28_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO28: view

Function for FBXO28 Gene

Molecular function for FBXO28 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Ontology (GO) - Molecular Function for FBXO28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FBXO28: view
genes like me logo Genes that share phenotypes with FBXO28: view

Animal Model Products

CRISPR Products

miRNA for FBXO28 Gene

miRTarBase miRNAs that target FBXO28

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO28 Gene

Localization for FBXO28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO28 Gene

Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO28 Gene COMPARTMENTS Subcellular localization image for FBXO28 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for FBXO28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
genes like me logo Genes that share ontologies with FBXO28: view

Pathways & Interactions for FBXO28 Gene

SuperPathways for FBXO28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO28 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO28 Gene

Drugs & Compounds for FBXO28 Gene

No Compound Related Data Available

Transcripts for FBXO28 Gene

Unigene Clusters for FBXO28 Gene

F-box protein 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for FBXO28 Gene

GeneLoc Exon Structure for
FBXO28
ECgene alternative splicing isoforms for
FBXO28

Expression for FBXO28 Gene

mRNA expression in normal human tissues for FBXO28 Gene

Protein differential expression in normal tissues from HIPED for FBXO28 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.3) and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXO28 Gene



Protein tissue co-expression partners for FBXO28 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO28 Gene:

FBXO28

SOURCE GeneReport for Unigene cluster for FBXO28 Gene:

Hs.64691
genes like me logo Genes that share expression patterns with FBXO28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO28 Gene

Orthologs for FBXO28 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO28 34
  • 94.2 (n)
  • 96.74 (a)
FBXO28 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO28 34
  • 89.67 (n)
  • 96.2 (a)
FBXO28 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo28 34
  • 90.26 (n)
  • 97.54 (a)
Fbxo28 16
Fbxo28 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO28 34
  • 99.73 (n)
  • 100 (a)
FBXO28 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo28 34
  • 90.46 (n)
  • 98.15 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO28 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves FBXO28 34
  • 81.94 (n)
  • 91.33 (a)
FBXO28 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO28 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo28 34
  • 74.39 (n)
  • 87.94 (a)
Str.16184 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13216 34
zebrafish
(Danio rerio)
Actinopterygii fbxo28 34
  • 67.61 (n)
  • 76.1 (a)
fbxo28 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11866 35
  • 18 (a)
OneToMany
pall 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for FBXO28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO28 Gene

ENSEMBL:
Gene Tree for FBXO28 (if available)
TreeFam:
Gene Tree for FBXO28 (if available)

Paralogs for FBXO28 Gene

No data available for Paralogs for FBXO28 Gene

Variants for FBXO28 Gene

Sequence variations from dbSNP and Humsavar for FBXO28 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_064713 -
rs8328 -- 224,159,257(+) GTTTT(A/G)GTAAG nc-transcript-variant, utr-variant-3-prime
rs908792 -- 224,133,518(-) taaaa(A/G)taaaG intron-variant
rs908793 -- 224,133,083(-) ggttc(A/G)ttctt intron-variant
rs908794 -- 224,116,237(-) ACAAA(A/G)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO28 Gene

Variant ID Type Subtype PubMed ID
esv2663158 CNV deletion 23128226
esv2759000 CNV gain+loss 17122850
esv3588968 CNV loss 21293372
esv3588969 CNV loss 21293372
nsv1133942 CNV deletion 24896259
nsv1133943 CNV deletion 24896259
nsv832692 CNV gain 17160897

Variation tolerance for FBXO28 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO28 Gene

Human Gene Mutation Database (HGMD)
FBXO28
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO28 Gene

Disorders for FBXO28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXO28 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 1q41-q42 deletion syndrome
  • 1q41-q42 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXO28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO28
genes like me logo Genes that share disorders with FBXO28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXO28 Gene

Publications for FBXO28 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4 65
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for FBXO28 Gene

Sources for FBXO28 Gene

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