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Aliases for FBXO28 Gene

Aliases for FBXO28 Gene

  • F-Box Protein 28 2 3
  • Centromere Protein 30 2 3
  • KIAA0483 4
  • CENP-30 3
  • Fbx28 3

External Ids for FBXO28 Gene

Previous GeneCards Identifiers for FBXO28 Gene

  • GC01P221277
  • GC01P220608
  • GC01P222368
  • GC01P224302
  • GC01P194822

Summaries for FBXO28 Gene

Entrez Gene Summary for FBXO28 Gene

  • Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO28 Gene

FBXO28 (F-Box Protein 28) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO28 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Wiki entry for FBXO28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO28 Gene

Genomics for FBXO28 Gene

Regulatory Elements for FBXO28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO28 Gene

Chromosome:
1
Start:
224,114,087 bp from pter
End:
224,162,047 bp from pter
Size:
47,961 bases
Orientation:
Plus strand

Genomic View for FBXO28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO28 Gene

Proteins for FBXO28 Gene

  • Protein details for FBXO28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVF7-FBX28_HUMAN
    Recommended name:
    F-box only protein 28
    Protein Accession:
    Q9NVF7
    Secondary Accessions:
    • E9PEM8
    • O75070

    Protein attributes for FBXO28 Gene

    Size:
    368 amino acids
    Molecular mass:
    41149 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

    Alternative splice isoforms for FBXO28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO28 Gene

Proteomics data for FBXO28 Gene at MOPED

Post-translational modifications for FBXO28 Gene

  • Ubiquitination at Lys 269
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO28 Gene

Antibody Products

No data available for DME Specific Peptides for FBXO28 Gene

Domains & Families for FBXO28 Gene

Gene Families for FBXO28 Gene

Protein Domains for FBXO28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO28 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVF7

UniProtKB/Swiss-Prot:

FBX28_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO28: view

Function for FBXO28 Gene

Molecular function for FBXO28 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Ontology (GO) - Molecular Function for FBXO28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FBXO28: view
genes like me logo Genes that share phenotypes with FBXO28: view

Animal Model Products

miRNA for FBXO28 Gene

miRTarBase miRNAs that target FBXO28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO28 Gene

Localization for FBXO28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO28 Gene COMPARTMENTS Subcellular localization image for FBXO28 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO28 Gene

Pathways & Interactions for FBXO28 Gene

SuperPathways for FBXO28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO28 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO28 Gene

Drugs & Compounds for FBXO28 Gene

No Compound Related Data Available

Transcripts for FBXO28 Gene

Unigene Clusters for FBXO28 Gene

F-box protein 28:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for FBXO28 Gene

GeneLoc Exon Structure for
FBXO28
ECgene alternative splicing isoforms for
FBXO28

Expression for FBXO28 Gene

mRNA expression in normal human tissues for FBXO28 Gene

Protein differential expression in normal tissues from HIPED for FBXO28 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.3) and Urine (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO28 Gene



SOURCE GeneReport for Unigene cluster for FBXO28 Gene Hs.64691

genes like me logo Genes that share expression patterns with FBXO28: view

Protein tissue co-expression partners for FBXO28 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO28 Gene

Orthologs for FBXO28 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO28 35
  • 94.2 (n)
  • 96.74 (a)
FBXO28 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO28 35
  • 89.67 (n)
  • 96.2 (a)
FBXO28 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo28 35
  • 90.26 (n)
  • 97.54 (a)
Fbxo28 16
Fbxo28 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO28 35
  • 99.73 (n)
  • 100 (a)
FBXO28 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo28 35
  • 90.46 (n)
  • 98.15 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO28 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves FBXO28 35
  • 81.94 (n)
  • 91.33 (a)
FBXO28 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO28 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo28 35
  • 74.39 (n)
  • 87.94 (a)
Str.16184 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13216 35
zebrafish
(Danio rerio)
Actinopterygii fbxo28 35
  • 67.61 (n)
  • 76.1 (a)
fbxo28 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11866 36
  • 18 (a)
OneToMany
pall 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for FBXO28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO28 Gene

ENSEMBL:
Gene Tree for FBXO28 (if available)
TreeFam:
Gene Tree for FBXO28 (if available)

Paralogs for FBXO28 Gene

No data available for Paralogs for FBXO28 Gene

Variants for FBXO28 Gene

Sequence variations from dbSNP and Humsavar for FBXO28 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8328 -- 224,159,257(+) GTTTT(A/G)GTAAG utr-variant-3-prime, nc-transcript-variant
rs869944 -- 224,134,010(-) ATATT(A/G)AGCAA intron-variant
rs869945 -- 224,133,935(-) TTAAC(C/T)GTAAT intron-variant
rs908792 -- 224,133,518(-) taaaa(A/G)taaaG intron-variant
rs908793 -- 224,133,083(-) ggttc(A/G)ttctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO28 Gene

Variant ID Type Subtype PubMed ID
dgv182e1 CNV Complex 17122850
essv6404 CNV CNV 17122850
nsv832692 CNV Gain 17160897
nsv873222 CNV Loss 21882294
esv2663158 CNV Deletion 23128226

Variation tolerance for FBXO28 Gene

Residual Variation Intolerance Score: 51.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO28 Gene

HapMap Linkage Disequilibrium report
FBXO28
Human Gene Mutation Database (HGMD)
FBXO28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO28 Gene

Disorders for FBXO28 Gene

Relevant External Links for FBXO28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO28
genes like me logo Genes that share disorders with FBXO28: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO28 Gene

Publications for FBXO28 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Refinement of the critical region of 1q41q42 microdeletion syndrome identifies FBXO28 as a candidate causative gene for intellectual disability and seizures. (PMID: 24357076) Au P.Y. … Micheil Innes A. (Am. J. Med. Genet. A 2014) 67
  5. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PMID: 23503679) Zhu J. … Elledge S.J. (Nat. Biotechnol. 2013) 67

Products for FBXO28 Gene

Sources for FBXO28 Gene

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