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Aliases for FBXO28 Gene

Aliases for FBXO28 Gene

  • F-Box Protein 28 2 3
  • Centromere Protein 30 2 3
  • KIAA0483 4 6
  • Fbx28 3 6
  • F-Box Only Protein 28 3
  • CENP-30 3

External Ids for FBXO28 Gene

Previous GeneCards Identifiers for FBXO28 Gene

  • GC01P221277
  • GC01P220608
  • GC01P222368
  • GC01P224302
  • GC01P194822

Summaries for FBXO28 Gene

Entrez Gene Summary for FBXO28 Gene

  • Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO28 Gene

FBXO28 (F-Box Protein 28) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXO28 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Wiki entry for FBXO28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO28 Gene

Genomics for FBXO28 Gene

Regulatory Elements for FBXO28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO28 Gene

224,114,087 bp from pter
224,162,047 bp from pter
47,961 bases
Plus strand

Genomic View for FBXO28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO28 Gene

Proteins for FBXO28 Gene

  • Protein details for FBXO28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 28
    Protein Accession:
    Secondary Accessions:
    • E9PEM8
    • O75070

    Protein attributes for FBXO28 Gene

    368 amino acids
    Molecular mass:
    41149 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

    Alternative splice isoforms for FBXO28 Gene


neXtProt entry for FBXO28 Gene

Proteomics data for FBXO28 Gene at MOPED

Post-translational modifications for FBXO28 Gene

  • Ubiquitination at Lys269
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO28 Gene

Antibody Products

No data available for DME Specific Peptides for FBXO28 Gene

Domains for FBXO28 Gene

Gene Families for FBXO28 Gene

Protein Domains for FBXO28 Gene


Suggested Antigen Peptide Sequences for FBXO28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO28: view

Function for FBXO28 Gene

Molecular function for FBXO28 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Gene Ontology (GO) - Molecular Function for FBXO28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with FBXO28: view

Phenotypes for FBXO28 Gene

GenomeRNAi human phenotypes for FBXO28:
genes like me logo Genes that share phenotypes with FBXO28: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO28 Gene

Localization for FBXO28 Gene

Subcellular locations from

Jensen Localization Image for FBXO28 Gene COMPARTMENTS Subcellular localization image for FBXO28 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO28 Gene

Pathways for FBXO28 Gene

SuperPathways for FBXO28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO28 Gene


No data available for Pathways by source for FBXO28 Gene

Transcripts for FBXO28 Gene

Unigene Clusters for FBXO28 Gene

F-box protein 28:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO28 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for FBXO28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO28 Gene

mRNA expression in normal human tissues for FBXO28 Gene

Protein differential expression in normal tissues for FBXO28 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.3) and Urine (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO28 Gene

SOURCE GeneReport for Unigene cluster for FBXO28 Gene Hs.64691

genes like me logo Genes that share expressions with FBXO28: view

Expression partners for FBXO28 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO28 Gene

Orthologs for FBXO28 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO28 35
  • 94.2 (n)
  • 96.74 (a)
FBXO28 36
  • 97 (a)
(Canis familiaris)
Mammalia FBXO28 35
  • 89.67 (n)
  • 96.2 (a)
FBXO28 36
  • 96 (a)
(Mus musculus)
Mammalia Fbxo28 35
  • 90.26 (n)
  • 97.54 (a)
Fbxo28 16
Fbxo28 36
  • 95 (a)
(Pan troglodytes)
Mammalia FBXO28 35
  • 99.73 (n)
  • 100 (a)
FBXO28 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo28 35
  • 90.46 (n)
  • 98.15 (a)
(Monodelphis domestica)
Mammalia FBXO28 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
-- 36
  • 95 (a)
(Gallus gallus)
Aves FBXO28 35
  • 81.94 (n)
  • 91.33 (a)
FBXO28 36
  • 88 (a)
(Anolis carolinensis)
Reptilia FBXO28 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo28 35
  • 74.39 (n)
  • 87.94 (a)
Str.16184 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13216 35
(Danio rerio)
Actinopterygii fbxo28 35
  • 67.61 (n)
  • 76.1 (a)
fbxo28 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11866 36
  • 18 (a)
pall 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for FBXO28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO28 Gene

Gene Tree for FBXO28 (if available)
Gene Tree for FBXO28 (if available)

Paralogs for FBXO28 Gene

No data available for Paralogs for FBXO28 Gene

Variants for FBXO28 Gene

Sequence variations from dbSNP and Humsavar for FBXO28 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8328 -- 224,159,257(+) GTTTT(A/G)GTAAG utr-variant-3-prime, nc-transcript-variant
rs869944 -- 224,134,010(-) ATATT(A/G)AGCAA intron-variant
rs869945 -- 224,133,935(-) TTAAC(C/T)GTAAT intron-variant
rs872283 -- 224,131,069(-) tttag(A/T)ataca intron-variant
rs908792 -- 224,133,518(-) taaaa(A/G)taaaG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO28 Gene

Variant ID Type Subtype PubMed ID
dgv182e1 CNV Complex 17122850
essv6404 CNV CNV 17122850
nsv832692 CNV Gain 17160897
nsv873222 CNV Loss 21882294
esv2663158 CNV Deletion 23128226

Relevant External Links for FBXO28 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO28 Gene

Disorders for FBXO28 Gene

No disorders were found for FBXO28 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FBXO28 Gene

Publications for FBXO28 Gene

  1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for FBXO28 Gene

Sources for FBXO28 Gene

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