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Aliases for FBXO27 Gene

Aliases for FBXO27 Gene

  • F-Box Protein 27 2 3
  • Fbx27 3 4 6
  • FBG5 3 4 6
  • F-Box/G-Domain Protein 5 3 4
  • F-Box Only Protein 27 2 3
  • F-Box Protein FBG5 3

External Ids for FBXO27 Gene

Summaries for FBXO27 Gene

Entrez Gene Summary for FBXO27 Gene

  • Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO27 Gene

FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is NCCRP1.

UniProtKB/Swiss-Prot for FBXO27 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene

Genomics for FBXO27 Gene

Genomic Location for FBXO27 Gene

Start:
38,990,714 bp from pter
End:
39,033,015 bp from pter
Size:
42,302 bases
Orientation:
Minus strand

Genomic View for FBXO27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO27 Gene

Regulatory Elements for FBXO27 Gene

Proteins for FBXO27 Gene

  • Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI29-FBX27_HUMAN
    Recommended name:
    F-box only protein 27
    Protein Accession:
    Q8NI29
    Secondary Accessions:
    • Q96C87

    Protein attributes for FBXO27 Gene

    Size:
    283 amino acids
    Molecular mass:
    31623 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.

neXtProt entry for FBXO27 Gene

Proteomics data for FBXO27 Gene at MOPED

Post-translational modifications for FBXO27 Gene

No Post-translational modifications

Other Protein References for FBXO27 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO27 Gene

Domains for FBXO27 Gene

Gene Families for FBXO27 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO27 Gene

Suggested Antigen Peptide Sequences for FBXO27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NI29

UniProtKB/Swiss-Prot:

FBX27_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q8NI29
  • Contains 1 FBA (F-box associated) domain.:
    • Q8NI29
genes like me logo Genes that share domains with FBXO27: view

Function for FBXO27 Gene

Molecular function for FBXO27 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Gene Ontology (GO) - Molecular Function for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IDA 18203720
GO:0005515 protein binding IPI 18203720
genes like me logo Genes that share ontologies with FBXO27: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO27 Gene

Localization for FBXO27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO27 Gene COMPARTMENTS Subcellular localization image for FBXO27 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 18203720
genes like me logo Genes that share ontologies with FBXO27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO27 Gene

Transcripts for FBXO27 Gene

mRNA/cDNA for FBXO27 Gene

Unigene Clusters for FBXO27 Gene

F-box protein 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for FBXO27 Gene

GeneLoc Exon Structure for
FBXO27
ECgene alternative splicing isoforms for
FBXO27

Expression for FBXO27 Gene

mRNA expression in normal human tissues for FBXO27 Gene

SOURCE GeneReport for Unigene cluster for FBXO27 Gene Hs.187461

mRNA Expression by UniProt/SwissProt for FBXO27 Gene

Q8NI29-FBX27_HUMAN
Tissue specificity: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.
genes like me logo Genes that share expressions with FBXO27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for FBXO27 Gene

Orthologs for FBXO27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO27 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 45 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FBXO27 35
  • 89.37 (n)
  • 89.96 (a)
FBXO27 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo27 35
  • 82 (n)
  • 79.71 (a)
Fbxo27 16
Fbxo27 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fbxo27 35
  • 81.11 (n)
  • 79.78 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo27 35
  • 53.08 (n)
  • 51.07 (a)
Species with no ortholog for FBXO27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO27 Gene

ENSEMBL:
Gene Tree for FBXO27 (if available)
TreeFam:
Gene Tree for FBXO27 (if available)

Paralogs for FBXO27 Gene

Paralogs for FBXO27 Gene

Selected SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXO27: view

Variants for FBXO27 Gene

Sequence variations from dbSNP and Humsavar for FBXO27 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs494515 -- 39,030,079(+) tcaag(A/G)gatct intron-variant
rs533573 -- 39,025,299(-) TACTG(A/G)GAATT utr-variant-3-prime
rs536244 -- 39,025,016(+) AACAA(C/T)AGGAG utr-variant-3-prime
rs541465 -- 39,032,343(-) AAGAC(A/G)GGGGT intron-variant
rs561148 -- 39,033,945(-) agcct(C/G)ggcga upstream-variant-2KB

Relevant External Links for FBXO27 Gene

HapMap Linkage Disequilibrium report
FBXO27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO27 Gene

Disorders for FBXO27 Gene

Relevant External Links for FBXO27

Genetic Association Database (GAD)
FBXO27
genes like me logo Genes that share disorders with FBXO27: view

No data available for UniProtKB/Swiss-Prot for FBXO27 Gene

Publications for FBXO27 Gene

  1. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 23
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 23
  3. [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F. … Goudemand M. (Nouv Rev Fr Hematol 1975) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3

Products for FBXO27 Gene

Sources for FBXO27 Gene

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