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Aliases for FBXO27 Gene

Aliases for FBXO27 Gene

  • F-Box Protein 27 2 3 5
  • F-Box/G-Domain Protein 5 3 4
  • F-Box Only Protein 27 2 3
  • Fbx27 3 4
  • FBG5 3 4
  • F-Box Protein FBG5 3

External Ids for FBXO27 Gene

Previous GeneCards Identifiers for FBXO27 Gene

  • GC19M040127
  • GC19M039905
  • GC19M044190
  • GC19M044206
  • GC19M039516
  • GC19M035961
  • GC19M039483

Summaries for FBXO27 Gene

Entrez Gene Summary for FBXO27 Gene

  • Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO27 Gene

FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO17.

UniProtKB/Swiss-Prot for FBXO27 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Additional gene information for FBXO27 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene

Genomics for FBXO27 Gene

Regulatory Elements for FBXO27 Gene

Enhancers for FBXO27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039029 1.1 ENCODE 78.7 +0.7 742 4 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF302 ZNF416 HNRNPL FBXO27 RN7SL566P FBL PAK4 PLEKHG2 ENSG00000266963 ENSG00000269688 PAF1 SUPT5H
GH19H039038 0.9 Ensembl ENCODE 77.7 -5.6 -5616 0 CTCF ZNF654 SP3 CEBPB REST RAD21 YY1 CC2D1A ZFHX2 GLIS1 FBXO27 GC19M039038
GH19H039045 0.9 ENCODE 74.3 -13.5 -13478 1 HDAC1 TBP PKNOX1 BMI1 ZBTB40 GATA2 ATF7 CREM SMARCA5 SP3 FBXO27 GC19M039038 GC19P039085
GH19H038988 1.2 Ensembl ENCODE 47.3 +43.6 43639 0 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 KLF7 SP3 TSHZ1 ZNF610 ZSCAN16 FBXO27 ENSG00000266963 ENSG00000269172 ENSG00000267375 ENSG00000269445 ENSG00000269792 LOC105372399 LGALS14 CATSPERG LOC100129935
GH19H039052 0.9 ENCODE 62.8 -20.7 -20708 2 MLX ZNF493 ZNF2 ZNF121 ZNF143 SP3 SP5 YY2 REST ZNF623 FBXO27 ENSG00000266963 ENSG00000269172 ENSG00000267375 ENSG00000269792 LOC105372399 ENSG00000269445 LGALS14 CATSPERG LOC100129935
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO27 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109362 885 1401 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF302 ZNF143

Genomic Location for FBXO27 Gene

Chromosome:
19
Start:
38,990,714 bp from pter
End:
39,032,785 bp from pter
Size:
42,072 bases
Orientation:
Minus strand

Genomic View for FBXO27 Gene

Genes around FBXO27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO27 Gene

Proteins for FBXO27 Gene

  • Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI29-FBX27_HUMAN
    Recommended name:
    F-box only protein 27
    Protein Accession:
    Q8NI29
    Secondary Accessions:
    • Q96C87

    Protein attributes for FBXO27 Gene

    Size:
    283 amino acids
    Molecular mass:
    31623 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.

neXtProt entry for FBXO27 Gene

Post-translational modifications for FBXO27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO27 Gene

No data available for DME Specific Peptides for FBXO27 Gene

Domains & Families for FBXO27 Gene

Gene Families for FBXO27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO27 Gene

Suggested Antigen Peptide Sequences for FBXO27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO27: view

No data available for UniProtKB/Swiss-Prot for FBXO27 Gene

Function for FBXO27 Gene

Molecular function for FBXO27 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Phenotypes From GWAS Catalog for FBXO27 Gene

Gene Ontology (GO) - Molecular Function for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 18203720
genes like me logo Genes that share ontologies with FBXO27: view
genes like me logo Genes that share phenotypes with FBXO27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO27
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO27 Gene

Localization for FBXO27 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO27 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 18203720
genes like me logo Genes that share ontologies with FBXO27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO27 Gene

Pathways & Interactions for FBXO27 Gene

genes like me logo Genes that share pathways with FBXO27: view

Gene Ontology (GO) - Biological Process for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO27: view

No data available for SIGNOR curated interactions for FBXO27 Gene

Drugs & Compounds for FBXO27 Gene

No Compound Related Data Available

Transcripts for FBXO27 Gene

Unigene Clusters for FBXO27 Gene

F-box protein 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO27
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for FBXO27 Gene

GeneLoc Exon Structure for
FBXO27
ECgene alternative splicing isoforms for
FBXO27

Expression for FBXO27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO27 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO27 Gene:

FBXO27

SOURCE GeneReport for Unigene cluster for FBXO27 Gene:

Hs.187461

mRNA Expression by UniProt/SwissProt for FBXO27 Gene:

Q8NI29-FBX27_HUMAN
Tissue specificity: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.

Evidence on tissue expression from TISSUES for FBXO27 Gene

  • Pancreas(4.3)
genes like me logo Genes that share expression patterns with FBXO27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO27 Gene

Orthologs for FBXO27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO27 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO27 33 34
  • 89.37 (n)
mouse
(Mus musculus)
Mammalia Fbxo27 33 16 34
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo27 33
  • 81.11 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 56 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo27 33
  • 53.08 (n)
Species where no ortholog for FBXO27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO27 Gene

ENSEMBL:
Gene Tree for FBXO27 (if available)
TreeFam:
Gene Tree for FBXO27 (if available)

Paralogs for FBXO27 Gene

Paralogs for FBXO27 Gene

(5) SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXO27: view

Variants for FBXO27 Gene

Sequence variations from dbSNP and Humsavar for FBXO27 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000031369 -- 39,021,937(+) ATTAC(A/G)GGTGT intron-variant
rs1000050828 -- 39,021,684(+) TTGAG(A/G)TGGAG intron-variant
rs1000057116 -- 39,020,968(+) TCCTG(C/T)CTCAG intron-variant
rs1000065194 -- 39,033,062(+) AAAAC(-/TG)AGACC upstream-variant-2KB
rs1000111855 -- 39,027,346(+) AACCA(C/T)GTGGG intron-variant

Variation tolerance for FBXO27 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO27 Gene

Disorders for FBXO27 Gene

Relevant External Links for FBXO27

Genetic Association Database (GAD)
FBXO27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO27

No disorders were found for FBXO27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO27 Gene

Publications for FBXO27 Gene

  1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn KA … Paulson HL (The Journal of biological chemistry 2008) 3 4 22 60
  2. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin GP … Guguen-Guillouzo C (Gene 2002) 3 4 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F … Goudemand M (Nouvelle revue francaise d'hematologie 1975) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for FBXO27 Gene

Sources for FBXO27 Gene

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