Aliases for FBXO27 Gene
Aliases for FBXO27 Gene
External Ids for FBXO27 Gene
- HGNC: 18753
- Entrez Gene: 126433
- Ensembl: ENSG00000161243
- OMIM: 609099
- UniProtKB: Q8NI29
Previous GeneCards Identifiers for FBXO27 Gene
- GC19M040127
- GC19M039905
- GC19M044190
- GC19M044206
- GC19M039516
- GC19M035961
- GC19M039483
Summaries for FBXO27 Gene
-
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO27 Gene
FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO17.
UniProtKB/Swiss-Prot for FBXO27 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene
Genomics for FBXO27 Gene
Regulatory Elements for FBXO27 Gene
Enhancers for FBXO27 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G039029 | 1.1 | ENCODE | 78.7 | +0.7 | 742 | 4.4 | HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 | FBXO27 FBL RPS16 ENSG00000267892 RN7SL566P ENSG00000269069 ENSG00000269688 ACTN4 EID2B PSMC4 |
| GH19G039038 | 1 | Ensembl ENCODE | 77.7 | -5.6 | -5616 | 0.4 | ZNF263 CTCF ZNF654 SP3 CEBPB ZFP37 REST RAD21 YY1 ZNF121 | FBXO27 GC19M039038 |
| GH19G039045 | 0.9 | ENCODE | 74.3 | -13.5 | -13478 | 1.4 | HDAC1 TBP PKNOX1 BMI1 ZBTB40 GATA2 CREM SMARCA5 SP3 ZNF280D | FBXO27 GC19M039038 GC19P039085 |
| GH19G039052 | 1 | ENCODE | 62.8 | -20.7 | -20708 | 2.3 | MLX ZNF493 ZNF2 ZNF48 ZNF121 ZNF143 SP3 SP5 YY2 REST | FBXO27 PAK4 ENSG00000269069 NFKBIB SIRT2 GC19M039038 GC19P039085 |
| GH19G038988 | 1.3 | Ensembl ENCODE | 47.3 | +43.6 | 43639 | 0.9 | HDGF SIN3A FEZF1 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 SP3 CAVIN1 | FBXO27 RYR1 GC19M038985 ENSG00000267992 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO27 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO27 gene promoter:
Regulatory Element Products
Genomic Location for FBXO27 Gene
- Chromosome:
- 19
- Start:
- 38,990,714 bp from pter
- End:
- 39,032,785 bp from pter
- Size:
- 42,072 bases
- Orientation:
- Minus strand
Genomic View for FBXO27 Gene
Genes around FBXO27 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
FBXO27 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO27 Gene
Proteins for FBXO27 Gene
-
Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NI29-FBX27_HUMAN
- Recommended name:
- F-box only protein 27
- Protein Accession:
- Q8NI29
- Q96C87
Protein attributes for FBXO27 Gene
- Size:
- 283 amino acids
- Molecular mass:
- 31623 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
Post-translational modifications for FBXO27 Gene
Other Protein References for FBXO27 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO27
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- Invitrogen Antibodies for FBXO27
- antibodies-online Antibodies for FBXO27: See all 29
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Protein Products
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- antibodies-online Proteins for FBXO27: See all 7
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- Search GeneTex for Proteins for FBXO27
Assay Products
- antibodies-online Kits for FBXO27: See all 15
No data available for DME Specific Peptides for FBXO27 Gene
Domains & Families for FBXO27 Gene
Gene Families for FBXO27 Gene
- HGNC:
Protein Domains for FBXO27 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO27 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO27 Gene
Function for FBXO27 Gene
Molecular function for FBXO27 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001948 | glycoprotein binding | IDA | 18203720 |
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18203720 |
Phenotypes for FBXO27 Gene
- GenomeRNAi human phenotypes for FBXO27:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO27 gene
-
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- Search ViGene Biosciences for FBXO27
CRISPR Products
-
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO27
- GenScript: Design CRISPR guide RNA sequences for FBXO27
miRNA for FBXO27 Gene
- miRTarBase miRNAs that target FBXO27
-
- hsa-mir-5698 (MIRT523754)
- hsa-mir-8055 (MIRT523755)
- hsa-mir-744-3p (MIRT523756)
- hsa-mir-6864-3p (MIRT523757)
- hsa-mir-3672 (MIRT523758)
- hsa-mir-4423-5p (MIRT523759)
- hsa-mir-6501-5p (MIRT523760)
- hsa-mir-143-5p (MIRT523761)
- hsa-mir-4430 (MIRT523762)
- hsa-mir-3652 (MIRT523763)
- hsa-mir-122-5p (MIRT523764)
- hsa-mir-504-3p (MIRT523765)
- hsa-mir-4294 (MIRT523766)
- hsa-mir-3135b (MIRT523767)
- hsa-mir-6499-3p (MIRT523768)
- hsa-mir-3622b-5p (MIRT531155)
- hsa-mir-5693 (MIRT531156)
miRNA Products
- Search ViGene Biosciences for FBXO27
Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for FBXO27
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO27 Gene
Localization for FBXO27 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 18203720 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO27 Gene
Pathways & Interactions for FBXO27 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXO27 Gene
4 Reactome pathways for FBXO27 Gene
Interacting Proteins for FBXO27 Gene
Selected Interacting proteins:
ENSP00000292853
Q8NI29-FBX27_HUMAN
for FBXO27 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXO27 Gene
Transcripts for FBXO27 Gene
mRNA/cDNA for FBXO27 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO27
-
Applied Biological Materials CRISPR for FBXO27
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO27
- GenScript: Design CRISPR guide RNA sequences for FBXO27
miRNA Products
- Search ViGene Biosciences for FBXO27
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO27
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO27 gene
Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for FBXO27
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO27
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | ||||||||||||||
| SP4: |
Expression for FBXO27 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO27 Gene:
FBXO27SOURCE GeneReport for Unigene cluster for FBXO27 Gene:
Hs.187461mRNA Expression by UniProt/SwissProt for FBXO27 Gene:
Q8NI29-FBX27_HUMAN
Tissue specificity:
Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.
Evidence on tissue expression from TISSUES for FBXO27 Gene
- Pancreas(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXO27
-
OriGene qPCR primer pairs for FBXO27
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO27 Gene
Orthologs for FBXO27 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO27 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO27 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo27 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo27 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo27 34 |
|
- Species where no ortholog for FBXO27 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXO27 Gene
(5) SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:
Variants for FBXO27 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031369 | -- | 39,021,937(+) | ATTAC(A/G)GGTGT | intron-variant | |
| rs1000050828 | -- | 39,021,684(+) | TTGAG(A/G)TGGAG | intron-variant | |
| rs1000057116 | -- | 39,020,968(+) | TCCTG(C/T)CTCAG | intron-variant | |
| rs1000065194 | -- | 39,033,062(+) | AAAAC(-/TG)AGACC | upstream-variant-2KB | |
| rs1000111855 | -- | 39,027,346(+) | AACCA(C/T)GTGGG | intron-variant |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.33;
26.30% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO27 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO27
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO27 Gene
Disorders for FBXO27 Gene
Relevant External Links for FBXO27
No disorders were found for FBXO27 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO27 Gene
Publications for FBXO27 Gene
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 22 64
- A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F. … Goudemand M. (Nouv Rev Fr Hematol 1975) 2 3 64
- Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3 64
Products for FBXO27 Gene
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- antibodies-online Antibodies for FBXO27: See all 29
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- ViGene Biosciences adenoviral particle packaged cDNA for FBXO27 gene
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- Horizon Cell Lines for FBXO27
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXO27
- VectorBuilder custom plasmid, inducible vectors for FBXO27
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO27
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO27 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
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