FBXO27 Gene
protein-coding GIFtS: 48
GCID: GC19M039516
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|
F-box protein 27(Previous name: F-box only protein 27 )
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Aliases
for FBXO27 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box Protein 271 2 | | F-Box/G-Domain Protein 52 3 | | FBG52 3 5 | | FBX273 5 | | Fbx271 2 | | Fbg51 | | F-Box Only Protein 271 2 | | F-Box Protein FBG52 |
Export aliases for FBXO27 gene to outside databasesPrevious GC identifers: GC19M040127 GC19M039905 GC19M044190 GC19M044206 GC19M035961 |
Summaries
for FBXO27 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXO27:
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Ableto recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides
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Genomic Views
for FBXO27 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXO27 gene promoter:
Sp1 MAZR SREBP-1c Pax-6 Lmo2 C/EBPalpha Roaz AREB6 ZIC2/Zic2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO27
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO27 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2FBXO27 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M039516: view genomic region
(about GC identifiers)
Start:
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39,514,661 bp from pter |
End:
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39,523,198 bp from pter |
Size:
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8,538 bases |
Orientation:
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minus strand |
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Proteins
for FBXO27 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29 (See
protein sequence)Recommended Name: F-box only protein 27 Size: 283 amino acids; 31623 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1
Secondary accessions: Q96C87Explore the universe of human proteins at neXtProt for FBXO27: NX_Q8NI29
FBXO27 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_849142.1
ENSEMBL proteins: ENSP00000292853 ENSP00000437662 Reactome Protein details: Q8NI29
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019005 | SCF ubiquitin ligase complex |
IDA | 18203720 |
FBXO27 for ontologies About GeneDecksing
FBXO27 Antibody Products:
Assay Products for FBXO27: |
Protein
Domains /
Families
for FBXO27 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO27 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NI29ProtoNet protein and cluster: Q8NI29 1 Blocks protein family: IPB007397 F-box associated region
UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29Similarity: Contains 1 F-box domainSimilarity: Contains 1 FBA (F-box associated) domain |
Function
for FBXO27 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Ableto recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FBXO27 for ontologies About GeneDecksing
|
Pathways & Interactions
for FBXO27 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for FBXO27
FBXO27 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO27
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/27 Interacting proteins for FBXO27 (Q8NI293 ENSP000002928534) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030163 | protein catabolic process |
IEA | -- |
FBXO27 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXO27 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXO27
Search CenterWatch for drugs/clinical trials and news about FBXO27 / FBX27
|
Transcripts
for FBXO27 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXO27 gene: NM_178820.3 Unigene Cluster for FBXO27: F-box protein 27 Hs.187461 [show with all ESTs]Unigene Representative Sequence: NM_1788202 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000292853(uc002okh.3) ENST00000509137
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO27 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO27 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXO27 (NM_178820) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO27 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO27 |
Additional cDNA sequence: AF436061.1 BC014527.2 BC030060.1 6 DOTS entries: DT.405318 DT.100699149 DT.100768797 DT.100812612 DT.91653415 DT.99965435 24/69 AceView cDNA sequences (see all 69): AW137280 AA421646 CR615928 BF809394 BV196099 BV195452 BG676007 BX327744 BI193057 BE904722 BC030060 BU181887 AF436061 BM045436 BI457334 BX093921 AI040483 BE905203 NM_178820 AW339501 BG830842 BE731228 BE731147 BF979780
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXO27
|
Expression
for FBXO27 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FBXO27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO27
SOURCE GeneReport for Unigene cluster: Hs.187461
UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29Tissue specificity: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung
SABiosciences Custom PCR Arrays for FBXO27
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO27
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27 |
Orthologs
for FBXO27 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXO27 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FBXO276 |
-- |
49(a) |
1 → many |
GL343870.1(120072-129691) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
27(a) |
1 → many |
GroupUn.464(7518-8665) |
ENSEMBL Gene Tree for FBXO27 (if available)
TreeFam Gene Tree for FBXO27 (if available) |
Paralogs
for FBXO27 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXO27 gene
- FBXO62 FBXO442 FBXO22 NCCRP12
4 SIMAP similar genes for FBXO27 using alignment to 4 protein entries: FBX27_HUMAN (see all proteins):FBXO17 FBXO2 FBXO44 FBXO6
FBXO27 for paralogs About GeneDecksing
|
Genomic Variants
for FBXO27 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO27 (39514661 - 39523198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBXO27: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO27 |
|
Disorders
/ Diseases
for FBXO27 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXO27 for disorders About GeneDecksing
OMIM gene information: 609099
OMIM disorders: --
3  diseases for FBXO27: About MalaCardschronic myeloid leukemia myeloid leukemia leukemia
Export disorders for FBXO27 gene to outside databases
|
Publications
for FBXO27 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO27 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with FBXO27) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 2, 9 Ilyin G.P....Guguen-Guillouzo C. (2002)
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2, 9 Glenn K.A.... Paulson H.L. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia] (PubMed id 126433)1, 3 Bauters F. and Goudemand M. (1975)
- Skp1 stabilizes the conformation of F-box proteins. (PubMed id 21640084)1 Yoshida Y....Tanaka K. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A novel route for F-box protein-mediated ubiquitinati on links CHIP to glycoprotein quality control. (PubMed id 16682404)1 Nelson R.F....Paulson H.L. (2006)
- Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. (PubMed id 16226712)1 Niture S.K....Srivenugopal K.S. (2005)
- Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1 Jin J....Harper J.W. (2004)
|
External Searches for FBXO27 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXO27 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO27 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXO27 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXO27 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXO27 gene:
Search GeneIP for patents involving FBXO27
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXO27 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27 |
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