Aliases for FBXO27 Gene
Aliases for FBXO27 Gene
External Ids for FBXO27 Gene
- HGNC: 18753
- Entrez Gene: 126433
- Ensembl: ENSG00000161243
- OMIM: 609099
- UniProtKB: Q8NI29
Previous GeneCards Identifiers for FBXO27 Gene
- GC19M040127
- GC19M039905
- GC19M044190
- GC19M044206
- GC19M039516
- GC19M035961
- GC19M039483
Summaries for FBXO27 Gene
-
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO27 Gene
FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is NCCRP1.
UniProtKB/Swiss-Prot for FBXO27 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene
Genomics for FBXO27 Gene
Regulatory Elements for FBXO27 Gene
Enhancers for FBXO27 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around FBXO27 on UCSC Golden Path with GeneCards custom track
Promoters for FBXO27 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around FBXO27 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO27 gene promoter:
Regulatory Element Products
Genomic Location for FBXO27 Gene
- Chromosome:
- 19
- Start:
- 38,990,714 bp from pter
- End:
- 39,032,785 bp from pter
- Size:
- 42,072 bases
- Orientation:
- Minus strand
Genomic View for FBXO27 Gene
Genes around FBXO27 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
FBXO27 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO27 Gene
Proteins for FBXO27 Gene
-
Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NI29-FBX27_HUMAN
- Recommended name:
- F-box only protein 27
- Protein Accession:
- Q8NI29
- Q96C87
Protein attributes for FBXO27 Gene
- Size:
- 283 amino acids
- Molecular mass:
- 31623 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
Post-translational modifications for FBXO27 Gene
Other Protein References for FBXO27 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO27
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- antibodies-online Antibodies for FBXO27: See all 29
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-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXO27
Protein Products
-
OriGene Purified Proteins for FBXO27
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- antibodies-online Proteins for FBXO27: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO27
Assay Products
- antibodies-online Kits for FBXO27: See all 15
No data available for DME Specific Peptides for FBXO27 Gene
Domains & Families for FBXO27 Gene
Gene Families for FBXO27 Gene
- HGNC:
Protein Domains for FBXO27 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO27 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NI29- Domain:
-
- Contains 1 F-box domain.
- Contains 1 FBA (F-box associated) domain.
Function for FBXO27 Gene
Molecular function for FBXO27 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 18203720 |
Phenotypes for FBXO27 Gene
- GenomeRNAi human phenotypes for FBXO27:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO27 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for FBXO27
-
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miRNA for FBXO27 Gene
- miRTarBase miRNAs that target FBXO27
-
- hsa-mir-5698 (MIRT523754)
- hsa-mir-8055 (MIRT523755)
- hsa-mir-744-3p (MIRT523756)
- hsa-mir-6864-3p (MIRT523757)
- hsa-mir-3672 (MIRT523758)
- hsa-mir-4423-5p (MIRT523759)
- hsa-mir-6501-5p (MIRT523760)
- hsa-mir-143-5p (MIRT523761)
- hsa-mir-4430 (MIRT523762)
- hsa-mir-3652 (MIRT523763)
- hsa-mir-122-5p (MIRT523764)
- hsa-mir-504-3p (MIRT523765)
- hsa-mir-4294 (MIRT523766)
- hsa-mir-3135b (MIRT523767)
- hsa-mir-6499-3p (MIRT523768)
- hsa-mir-3622b-5p (MIRT531155)
- hsa-mir-5693 (MIRT531156)
miRNA Products
- Search ViGene Biosciences for FBXO27
Clone Products
- OriGene clones in human for FBXO27
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO27 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO27 Gene
Localization for FBXO27 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| nucleus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO27 Gene
Pathways & Interactions for FBXO27 Gene
More details on SuperPathways for FBXO27Pathways by source for FBXO27 Gene
4 Reactome pathways for FBXO27 Gene
Interacting Proteins for FBXO27 Gene
No data available for SIGNOR curated interactions for FBXO27 Gene
Transcripts for FBXO27 Gene
mRNA/cDNA for FBXO27 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO27
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO27
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miRNA Products
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Clone Products
- OriGene clones in human for FBXO27
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | ||||||||||||||
| SP4: |
Expression for FBXO27 Gene
SOURCE GeneReport for Unigene cluster for FBXO27 Gene Hs.187461
mRNA Expression by UniProt/SwissProt for FBXO27 Gene
Q8NI29-FBX27_HUMAN
Tissue specificity:
Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXO27
-
OriGene qPCR primer pairs for FBXO27
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FBXO27 Gene
Orthologs for FBXO27 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | FBXO27 35 |
|
||
| FBXO27 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Fbxo27 35 |
|
||
| Fbxo27 16 |
|
||||
| Fbxo27 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Fbxo27 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| -- 36 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
ManyToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO27 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo27 35 |
|
- Species with no ortholog for FBXO27:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXO27 Gene
(5) SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:
Variants for FBXO27 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7258182 | -- | 39,030,288(+) | TTGTC(A/T)TTGCA | intron-variant | |
| rs7258997 | -- | 39,023,688(+) | GGCTC(A/T)CTGCA | downstream-variant-500B | |
| rs7259800 | -- | 39,023,529(+) | CATGC(G/T)TTTCT | downstream-variant-500B | |
| rs7259801 | -- | 39,032,444(+) | GCCCC(A/G)AATTG | intron-variant | |
| rs12978749 | -- | 39,026,536(+) | ATGGC(A/G)CAATC | intron-variant |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.33;
26.30% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FBXO27 Gene
Disorders for FBXO27 Gene
Relevant External Links for FBXO27
No disorders were found for FBXO27 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO27 Gene
Publications for FBXO27 Gene
- A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 23 67
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 23
- [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F. … Goudemand M. (Nouv Rev Fr Hematol 1975) 2 3
- Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3
- Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
Products for FBXO27 Gene
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- Custom Antibody ServicesOriGene Antibodies for FBXO27
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- antibodies-online Antibodies for FBXO27: See all 29
- antibodies-online Kits for FBXO27: See all 15
- antibodies-online Proteins for FBXO27: See all 7
- Search antibodies-online for peptides
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- Search GeneTex for Proteins for FBXO27
- ViGene Biosciences adenoviral particle packaged cDNA for FBXO27 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for FBXO27
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Sources for FBXO27 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (39) FlyBase
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- (45) GenAtlas
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- (50) BGMUT
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- (52) eBioscience
- (53) Atlas
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