Aliases for FBXO27 Gene
Aliases for FBXO27 Gene
External Ids for FBXO27 Gene
- HGNC: 18753
- Entrez Gene: 126433
- Ensembl: ENSG00000161243
- OMIM: 609099
- UniProtKB: Q8NI29
Previous GeneCards Identifiers for FBXO27 Gene
- GC19M040127
- GC19M039905
- GC19M044190
- GC19M044206
- GC19M039516
- GC19M035961
- GC19M039483
Summaries for FBXO27 Gene
-
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO27 Gene
FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXO17.
UniProtKB/Swiss-Prot for FBXO27 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
Additional gene information for FBXO27 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene
Genomics for FBXO27 Gene
GeneHancer (GH) Regulatory Elements for FBXO27 Gene
Promoters and enhancers for FBXO27 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FBXO27 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FBXO27 Gene
Genomic Locations for FBXO27 Gene
- chr19:38,990,714-39,032,785
- (GRCh38/hg38)
- Size:
- 42,072 bases
- Orientation:
- Minus strand
- chr19:39,481,354-39,523,425
- (GRCh37/hg19)
Genomic View for FBXO27 Gene
Genes around FBXO27 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
FBXO27 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO27 Gene
Proteins for FBXO27 Gene
-
Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NI29-FBX27_HUMAN
- Recommended name:
- F-box only protein 27
- Protein Accession:
- Q8NI29
- Q96C87
Protein attributes for FBXO27 Gene
- Size:
- 283 amino acids
- Molecular mass:
- 31623 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
Post-translational modifications for FBXO27 Gene
No Post-translational modifications
Other Protein References for FBXO27 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXO27
- Novus Biologicals Antibodies for FBXO27
- Invitrogen Antibodies for FBXO27
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Protein Products
-
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- antibodies-online: Search results for 6 available FBXO27 Proteins ranked by validation data
- Compare Top FBXO27 Proteins
-
Quality Products:
- Search GeneTex for Proteins for FBXO27
-
Abcam proteins for FBXO27
Assay Products
No data available for DME Specific Peptides for FBXO27 Gene
Domains & Families for FBXO27 Gene
Gene Families for FBXO27 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FBXO27 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO27 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO27 Gene
Function for FBXO27 Gene
Molecular function for FBXO27 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
Phenotypes From GWAS Catalog for FBXO27 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18203720 |
Phenotypes for FBXO27 Gene
- GenomeRNAi human phenotypes for FBXO27:
Animal Model Products
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-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO27
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miRNA for FBXO27 Gene
- miRTarBase miRNAs that target FBXO27
-
- hsa-mir-5698 (MIRT523754)
- hsa-mir-8055 (MIRT523755)
- hsa-mir-744-3p (MIRT523756)
- hsa-mir-6864-3p (MIRT523757)
- hsa-mir-3672 (MIRT523758)
- hsa-mir-4423-5p (MIRT523759)
- hsa-mir-6501-5p (MIRT523760)
- hsa-mir-143-5p (MIRT523761)
- hsa-mir-4430 (MIRT523762)
- hsa-mir-3652 (MIRT523763)
- hsa-mir-122-5p (MIRT523764)
- hsa-mir-504-3p (MIRT523765)
- hsa-mir-4294 (MIRT523766)
- hsa-mir-3135b (MIRT523767)
- hsa-mir-6499-3p (MIRT523768)
- hsa-mir-3622b-5p (MIRT531155)
- hsa-mir-5693 (MIRT531156)
miRNA Products
- Search ViGene Biosciences for FBXO27
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FBXO27
- Browse OriGene Inhibitory RNA Products For FBXO27
- genomics-online: shRNA clones - Search results for available FBXO27 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO27 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FBXO27
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FBXO27 gene related products
- orf clones - Search results for available FBXO27 gene related products
- Applied Biological Materials Clones for FBXO27
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FBXO27
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO27 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO27 gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO27 Gene
Localization for FBXO27 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 18203720 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO27 Gene
Pathways & Interactions for FBXO27 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXO27 Gene
4 Reactome pathways for FBXO27 Gene
Interacting Proteins for FBXO27 Gene
Selected Interacting proteins:
Q8NI29-FBX27_HUMAN
ENSP00000292853
for FBXO27 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXO27 Gene
Transcripts for FBXO27 Gene
mRNA/cDNA for FBXO27 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO27
- genomics-online: gRNA clones - Search results for available FBXO27 gene related products
- Applied Biological Materials CRISPR for FBXO27
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO27
- GenScript: Design CRISPR guide RNA sequences for FBXO27
miRNA Products
- Search ViGene Biosciences for FBXO27
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for FBXO27
- Browse OriGene Inhibitory RNA Products For FBXO27
- genomics-online: shRNA clones - Search results for available FBXO27 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO27 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FBXO27
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO27
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FBXO27 gene related products
- orf clones - Search results for available FBXO27 gene related products
- Applied Biological Materials Clones for FBXO27
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: | - | ||||||||||||||
| SP4: |
Expression for FBXO27 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO27 Gene:
FBXO27SOURCE GeneReport for Unigene cluster for FBXO27 Gene:
Hs.187461mRNA Expression by UniProt/SwissProt for FBXO27 Gene:
Q8NI29-FBX27_HUMAN
Tissue specificity:
Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.
Evidence on tissue expression from TISSUES for FBXO27 Gene
- Pancreas(4.3)
Primer Products
-
OriGene qPCR primer pairs for FBXO27
-
OriGene qPCR primer pairs and template standards for FBXO27
- genomics-online: primer clones - Search results for available FBXO27 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO27 Gene
Orthologs for FBXO27 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO27 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO27 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo27 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo27 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo27 33 |
|
- Species where no ortholog for FBXO27 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXO27 Gene
(5) SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:
Variants for FBXO27 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000031369 | -- | 39,021,937(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000050828 | -- | 39,021,684(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000057116 | -- | 39,020,968(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000065194 | -- | 39,033,062(-) | TG/ | upstream_transcript_variant | |
| rs1000111855 | -- | 39,027,346(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.33;
26.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FBXO27 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO27
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO27 Gene
Disorders for FBXO27 Gene
Additional Disease Information for FBXO27
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FBXO27 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO27 Gene
Publications for FBXO27 Gene
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn KA … Paulson HL (The Journal of biological chemistry 2008) 3 4 22 58
- A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin GP … Guguen-Guillouzo C (Gene 2002) 3 4 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F … Goudemand M (Nouvelle revue francaise d'hematologie 1975) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for FBXO27 Gene
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for FBXO27
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXO27
- VectorBuilder custom plasmid, inducible vectors for FBXO27
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO27
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 35 available FBXO27 Antibodies ranked by validation data
- Compare Top FBXO27 Antibodies
- antibodies-online: Search results for 12 available FBXO27 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 6 available FBXO27 Proteins ranked by validation data
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- Quality Products:
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- ViGene Biosciences adenoviral particle packaged cDNA for FBXO27 gene
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- Search ViGene Biosciences for FBXO27
- Horizon Cell Lines for FBXO27
- genomics-online: cdna clones - Search results for available FBXO27 gene related products
- orf clones - Search results for available FBXO27 gene related products
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- genomics-online: primer clones - Search results for available FBXO27 gene related products
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Sources for FBXO27 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
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