FBXO27 Gene protein-coding GIFtS : 48 GCID: GC19 M039483
F-Box Protein 27 F-box only protein 27 )
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Aliasesfor FBXO27 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases F-Box Protein 27 1 2 FBX273 5 FBG52 3 5 Fbx272 F-Box Only Protein 271 2 F-Box Protein FBG52 F-Box/G-Domain Protein 52 3
Export aliases for FBXO27 gene to outside databases Previous GC identifers: GC19M040127 GC19M039905 GC19M044190 GC19M044206 GC19M039516 GC19M035961
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Summariesfor FBXO27 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FBXO27 Gene: Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-boxmotif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact withubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(suppliedby OMIM, Mar 2008) GeneCards Summary for FBXO27 Gene: FBXO27 (F-box protein 27) is a protein-coding gene. Diseases associated with FBXO27 include chronic myeloid leukemia myeloid leukemia related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System . GO annotations related to this gene include protein binding and glycoprotein binding . An important paralog of this gene is FBXO17 . UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides
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Genomic Viewsfor FBXO27 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.2 NT_011109.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO27 gene promoter:Sp1 MAZR SREBP-1c Pax-6 Lmo2 C/EBPalpha Roaz AREB6 ZIC2/Zic2 Zic3 Other transcription factors Search SABiosciences Chromatin IP Primers for FBXO27 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2 FBXO27 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M039483: view genomic region
(about GC identifiers )
Start: 39,481,354 bp from pter End:
39,523,425 bp from pter
Size: 42,072 bases Orientation:
minus strand
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Proteinsfor FBXO27 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29 See
protein sequence )Recommended Name: Size : 283 amino acids; 31623 DaSubunit : Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1Secondary accessions : Q96C87Explore the universe of human proteins at neXtProt for FBXO27: NX_Q8NI29 Explore proteomics data for FBXO27 at MOPED FBXO27 Protein expression data from MOPED1 2 3 : About this image
REFSEQ proteins: NP_849142.1 ENSEMBL proteins: ENSP00000471267 ENSP00000292853 ENSP00000470015 ENSP00000471772 ENSP00000437662 Reactome Protein details: Q8NI29 Human Recombinant Protein Products for FBXO27: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0019005 SCF ubiquitin ligase complex
IDA 18203720
About GeneDecksing FBXO27 Antibody Products: Assay Products for FBXO27:
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Protein
Domains /for FBXO27 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: FBXO: F-boxes / "other" 3 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q8NI29 ProtoNet protein and cluster: Q8NI29
1 Blocks protein domain : IPB007397 UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29 Similarity : Contains 1 F-box domainSimilarity : Contains 1 FBA (F-box associated) domainAbout GeneDecksing
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Functionfor FBXO27 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: FBX27_HUMAN, Q8NI29 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for FBXO27 Search LifeMap BioReagents cell lines for FBXO27 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27
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Pathways & Interactionsfor FBXO27 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for FBXO27 About See pathways by source SuperPath Contained pathways About 1 Antigen processing: Ubiquitination & Proteasome degradation 2 Immune System
Pathways by source See SuperPaths Show all pathways 4 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO27 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/27 Interacting proteins for FBXO27 (Q8NI29 3 ENSP00000292853 4 via UniProtKB, MINT, STRING , and/or I2D (see all 27 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030163 protein catabolic process
IEA --
About GeneDecksing
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Drugs & Compoundsfor FBXO27 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FBXO27 (FBX27) FBXO27 / FBX27
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Transcriptsfor FBXO27 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FBXO27 gene: NM_178820.3 Unigene Cluster for FBXO27:
F-box protein 27 Hs.187461 [show with all ESTs ] Unigene Representative Sequence: NM_178820 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000598394 ENST00000292853 (uc002okh.3 ) ENST00000600828 ENST00000594770 ENST00000595166 ENST00000593847 ENST00000509137 Primer FBXO27 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AF436061.1 BC014527.2 BC030060.1
6 DOTS entries : DT.405318 DT.100699149
DT.100768797 DT.100812612 DT.91653415 DT.99965435 24/69 AceView cDNA sequences (see all 69 ):
BF809394 AA421646 CR615928 AW137280 BU181887 BG183119 BF979780 BX506083 BG170755 BC030060 BG830602 NM_178820 BX327744 AI040483 BM045436 BG830842 BV195452 BV196099 BX377759 BE905203 BQ686372 BG676007 BI602178 BE904722 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27 About this scheme ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 SP1 : - SP2 : - SP3 : - SP4 :
ECgene alternative splicing isoforms for FBXO27
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Expression for FBXO27 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FBXO27 expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: -- About this image
See FBXO27 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXO27 SOURCE GeneReport for Unigene cluster: Hs.187461 UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29 Tissue specificity : Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver andlung SABiosciences Custom PCR Arrays for FBXO27 Primer FBXO27 human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27
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Orthologsfor FBXO27 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for FBXO27 gene from 2/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for FBXO27 (if available)TreeFam Gene Tree for FBXO27 (if available)
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Paralogsfor FBXO27 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FBXO27 gene FBXO17 2 FBXO6 2 FBXO2 2 FBXO44 2 NCCRP1 2 5 SIMAP similar genes for FBXO27 using alignment to 4 protein entries: FBX27_HUMAN (see all proteins ):FBXO17 ETFA FBXO2 FBXO44 FBXO6 About GeneDecksing
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Genomic Variantsfor FBXO27 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 19 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for FBXO27 (39481354 - 39523425 bp)
Structural Variations Database of Genomic Variants (DGV) variations for FBXO27: -- SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FBXO27
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Disorders
/ Diseasesfor FBXO27 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 609099
OMIM disorders : --3 : About MalaCards chronic myeloid leukemia myeloid leukemia leukemia About GeneDecksing Genetic Association Database (GAD): FBXO27 Export disorders for FBXO27 gene to outside databases
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Publicationsfor FBXO27 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FBXO27 gene, integrated from 9 sources (see all 14 ):(articles sorted by number of sources associating them with FBXO27) Utopia : connect your pdf to the dynamic
A new subfamily of structurally related human F-box proteins. (PubMed id 12383498) 1 , 2 , 9(2002) Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720) 1 , 2 , 9(2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia] (PubMed id 126433) 1 , 3(1975) Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991) 1 (2013) Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624) 1 (2012) Skp1 stabilizes the conformation of F-box proteins. (PubMed id 21640084) 1 (2011) A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614) 4 Paterson A.D....Bull S.B. (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 (2007)
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External Searches for FBXO27 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FBXO27 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FBXO27 gene
(According to HUGE )
About This Section --
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Specialized Databases showing FBXO27 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for FBXO27 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FBXO27 gene: FBXO27 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FBXO27 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO27 QIAGEN SeqTarget long-range PCR primers for resequencing FBXO27 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27
ThermoFisher Antibodies for FBXO27
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO27
LSBio Antibodies in human mouse rat
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Function for FBXO27
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Intellectual Property for FBXO27
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