Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO27 Gene

protein-coding   GIFtS: 48
GCID: GC19M039483

F-Box Protein 27

(Previous name: F-box only protein 27)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 271 2     FBX273 5
FBG52 3 5     Fbx272
F-Box Only Protein 271 2     F-Box Protein FBG52
F-Box/G-Domain Protein 52 3     

External Ids:    HGNC: 187531   Entrez Gene: 1264332   Ensembl: ENSG000001612437   OMIM: 6090995   UniProtKB: Q8NI293   

Export aliases for FBXO27 gene to outside databases

Previous GC identifers: GC19M040127 GC19M039905 GC19M044190 GC19M044206 GC19M039516 GC19M035961


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO27 Gene:
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXO27 Gene: 
FBXO27 (F-box protein 27) is a protein-coding gene. Diseases associated with FBXO27 include chronic myeloid leukemia, and myeloid leukemia, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include protein binding and glycoprotein binding. An important paralog of this gene is FBXO17.

UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO27 gene promoter:
         Sp1   MAZR   SREBP-1c   Pax-6   Lmo2   C/EBPalpha   Roaz   AREB6   ZIC2/Zic2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO27 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

FBXO27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO27 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039483:  view genomic region     (about GC identifiers)

Start:
39,481,354 bp from pter      End:
39,523,425 bp from pter
Size:
42,072 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29 (See protein sequence)
Recommended Name: F-box only protein 27  
Size: 283 amino acids; 31623 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1
Secondary accessions: Q96C87

Explore the universe of human proteins at neXtProt for FBXO27: NX_Q8NI29

Explore proteomics data for FBXO27 at MOPED 

FBXO27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

FBXO27 Protein Expression

REFSEQ proteins: NP_849142.1  
ENSEMBL proteins: 
 ENSP00000471267   ENSP00000292853   ENSP00000470015   ENSP00000471772   ENSP00000437662  
Reactome Protein details: Q8NI29
Human Recombinant Protein Products for FBXO27: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for FBXO27
OriGene Protein Over-expression Lysate for FBXO27
OriGene MassSpec for FBXO27 
OriGene Custom Protein Services for FBXO27
GenScript Custom Purified and Recombinant Proteins Services for FBXO27
Novus Biologicals FBXO27 Proteins
Novus Biologicals FBXO27 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for FBXO27 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0019005SCF ubiquitin ligase complex IDA18203720

FBXO27 for ontologies           About GeneDecksing



FBXO27 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for FBXO27
GenScript Custom Superior Antibodies Services for FBXO27
Novus Biologicals FBXO27 Antibodies
Abcam antibodies for FBXO27
Cloud-Clone Corp. Antibodies for FBXO27 
ThermoFisher Antibodies for FBXO27
LSBio Antibodies in human, mouse, rat for FBXO27 

Assay Products for FBXO27: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FBXO27
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for FBXO27
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FBXO27 
Cloud-Clone Corp. CLIAs for FBXO27


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
FBXO: F-boxes / "other"

3 InterPro protein domains:
 IPR007397 F-box-assoc_dom
 IPR008979 Galactose-bd-like
 IPR001810 F-box_dom_cyclin-like

Graphical View of Domain Structure for InterPro Entry Q8NI29

ProtoNet protein and cluster: Q8NI29

1 Blocks protein domain: IPB007397 F-box associated region

UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29
Similarity: Contains 1 F-box domain
Similarity: Contains 1 FBA (F-box associated) domain


FBXO27 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FBX27_HUMAN, Q8NI29
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001948glycoprotein binding IDA18203720
GO:0005515protein binding IPI18203720
     
FBXO27 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO27 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO27

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO27 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO27 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO27
8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO27 (see all 17):
hsa-miR-1321 hsa-miR-185* hsa-miR-15a hsa-miR-124 hsa-miR-424 hsa-miR-506 hsa-miR-556-3p hsa-miR-195
SwitchGear 3'UTR luciferase reporter plasmidFBXO27 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FBXO27
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO27

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for FBXO27
Sirion Biotech Customized adenovirus for overexpression of FBXO27

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for FBXO27 (see all 9)
OriGene ORF clones in mouse, rat for FBXO27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXO27 (NM_178820)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO27
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO27
Sirion Biotech Customized lentivirus for stable overexpression of FBXO27 
                     Customized lentivirus expression plasmids for stable overexpression of FBXO27 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for FBXO27
Search LifeMap BioReagents cell lines for FBXO27
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for FBXO27 About                                                                                                See pathways by source

SuperPathContained pathways About
1Antigen processing: Ubiquitination & Proteasome degradation
Antigen processing: Ubiquitination & Proteasome degradation0.83
Class I MHC mediated antigen processing & presentation0.83
2Immune System
Immune System0.56
Adaptive Immune System0.56

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for FBXO27
    Antigen processing: Ubiquitination & Proteasome degradation
Adaptive Immune System
Class I MHC mediated antigen processing & presentation
Immune System



FBXO27 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO27

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for FBXO27 (Q8NI293 ENSP000002928534) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
InteractantInteraction Details
GeneCardExternal ID(s)
CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
STUB1Q9UNE73, ENSP000002195484I2D: score=1 STRING: ENSP00000219548
SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
FBXO44ENSP000002515474STRING: ENSP00000251547
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030163protein catabolic process IEA--

FBXO27 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FBXO27 (FBX27)

Search CenterWatch for drugs/clinical trials and news about FBXO27 / FBX27

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FBXO27 gene: 
NM_178820.3  

Unigene Cluster for FBXO27:

F-box protein 27
Hs.187461  [show with all ESTs]
Unigene Representative Sequence: NM_178820
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000598394 ENST00000292853(uc002okh.3) ENST00000600828 ENST00000594770
ENST00000595166 ENST00000593847 ENST00000509137
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO27
8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO27 (see all 17):
hsa-miR-1321 hsa-miR-185* hsa-miR-15a hsa-miR-124 hsa-miR-424 hsa-miR-506 hsa-miR-556-3p hsa-miR-195
SwitchGear 3'UTR luciferase reporter plasmidFBXO27 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for FBXO27
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO27
Clone
Products:
     
OriGene clones in human, mouse for FBXO27 (see all 9)
OriGene ORF clones in mouse, rat for FBXO27
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXO27 (NM_178820)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO27
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO27
Sirion Biotech Customized lentivirus for stable overexpression of FBXO27 
                     Customized lentivirus expression plasmids for stable overexpression of FBXO27 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FBXO27
OriGene qSTAR qPCR primer pairs in human, mouse for FBXO27
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO27
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO27
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO27

Additional mRNA sequence: 

AF436061.1 BC014527.2 BC030060.1 

6 DOTS entries:

DT.405318  DT.100699149  DT.100768797  DT.100812612  DT.91653415  DT.99965435 

24/69 AceView cDNA sequences (see all 69):

BF809394 AA421646 CR615928 AW137280 BU181887 BG183119 BF979780 BX506083 
BG170755 BC030060 BG830602 NM_178820 BX327744 AI040483 BM045436 BG830842 
BV195452 BV196099 BX377759 BE905203 BQ686372 BG676007 BI602178 BE904722 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:                    -                           
SP2:                    -                           
SP3:                    -                           
SP4:                                                


ECgene alternative splicing isoforms for FBXO27

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBXO27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FBXO27 Expression
About this image


See FBXO27 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO27

SOURCE GeneReport for Unigene cluster: Hs.187461

UniProtKB/Swiss-Prot: FBX27_HUMAN, Q8NI29
Tissue specificity: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and
lung

    SABiosciences Custom PCR Arrays for FBXO27
Primer
Products:
OriGene qPCR primer pairs and template standards for FBXO27
OriGene qSTAR qPCR primer pairs in human, mouse for FBXO27
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO27
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO27
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO27
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for FBXO27 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fbxo271 , 5 F-box protein 271, 5 82.07(n)1
79.78(a)1
  7 (16.89 cM)5
2330401  NM_001163702.11  NP_001157174.11 
 286928495 
lizard
(Anolis carolinensis)
Reptilia FBXO276
Uncharacterized protein
48(a)
1 → many
GL343870.1(120044-129712)


ENSEMBL Gene Tree for FBXO27 (if available)
TreeFam Gene Tree for FBXO27 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for FBXO27 gene
FBXO172  FBXO62  FBXO22  FBXO442  NCCRP12  
5 SIMAP similar genes for FBXO27 using alignment to 4 protein entries:     FBX27_HUMAN (see all proteins):
FBXO17    ETFA    FBXO2    FBXO44    FBXO6

FBXO27 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/286 SNPs in FBXO27 are shown (see all 286)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs72598001,2
C,F--35961350(+) CATGCT/GTTTCT 1 -- int12Minor allele frequency- G:0.10WA NA 238
rs65088391,2
C,F,A,H--35961460(+) ACGGAA/GTCTCG 1 -- int19Minor allele frequency- G:0.47NA WA EA 372
rs1412471661,2
--35961464(+) AGTCTC/TGCTCT 1 -- int10--------
rs1872376021,2
--35961465(+) GTCTCA/GCTCTT 1 -- int10--------
rs1508102151,2
--35961472(+) TCTTTC/TGCCCA 1 -- int10--------
rs1394003761,2
--35961487(+) GGAGCA/GCAGTG 1 -- int10--------
rs72589971,2
C--35961508(+) GGCTCA/TCTGCA 1 -- int10--------
rs65088401,2
C,F,A,H--35961558(+) CCTCCT/CGAGTA 1 -- int15Minor allele frequency- C:0.20NA WA 10
rs1894073191,2
C--35961574(+) GATTAC/TAGGCG 1 -- int10--------
rs1397981261,2
--35961588(+) GCCACC/TATGCC 1 -- int10--------

HapMap Linkage Disequilibrium report for FBXO27 (39481354 - 39523425 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FBXO27: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing FBXO27
DNA2.0 Custom Variant and Variant Library Synthesis for FBXO27

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609099    OMIM disorders: --

3 diseases for FBXO27:    About MalaCards
chronic myeloid leukemia    myeloid leukemia    leukemia


FBXO27 for disorders           About GeneDecksing

Genetic Association Database (GAD): FBXO27

Export disorders for FBXO27 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for FBXO27 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with FBXO27)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 2, 9 Ilyin G.P....Guguen-Guillouzo C. (2002)
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2, 9 Glenn K.A.... Paulson H.L. (2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia] (PubMed id 126433)1, 3 Bauters F. and Goudemand M. (1975)
  5. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (2013)
  6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
  7. Skp1 stabilizes the conformation of F-box proteins. (PubMed id 21640084)1 Yoshida Y....Tanaka K. (2011)
  8. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
  9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 126433 HGNC: 18753 AceView: FBXO27 Ensembl:ENSG00000161243 euGenes: HUgn126433
ECgene: FBXO27 H-InvDB: FBXO27

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for FBXO27 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for FBXO27 gene:
Search GeneIP for patents involving FBXO27

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXO27  
 OriGene qPCR primer pairs and template standards for FBXO27   OriGene Protein Over-expression Lysate for FBXO27  
 OriGene MassSpec something-or-other for FBXO27   OriGene clones in human, mouse for FBXO27  
 OriGene qSTAR qPCR primer pairs in human, mouse for FBXO27   OriGene Purified Protein for FBXO27  
 OriGene ORF clones in mouse, rat for FBXO27   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for FBXO27   OriGene Custom Protein Services for FBXO27  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO27
 QIAGEN SeqTarget long-range PCR primers for resequencing FBXO27
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO27
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO27
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO27
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO27
 GenScript Custom Purified and Recombinant Proteins Services for FBXO27 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO27
 GenScript Custom Assay Services for FBXO27 GenScript Custom Superior Antibodies Services for FBXO27
 GenScript Custom overexpressing Cell Line Services for FBXO27 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in FBXO27 promoter
 Search Chromatin IP Primers for FBXO27
 RT2 qPCR Primer Assay in human, mouse, rat FBXO27
 Search GNC Networks for FBXO27
 SABiosciences Custom PCR Arrays for FBXO27
 Search Tocris compounds for FBXO27 (FBX27)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 FBXO27 antibodies
 FBXO27 proteins
 FBXO27 lysates
 Antibodies for FBXO27
 See all of Abcam's Antibodies, Kits and Proteins for FBXO27
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for FBXO27
 Antibodies for FBXO27
 ELISAs for FBXO27
 CLIAs for FBXO27
 Search LifeMap BioReagents cell lines for FBXO27
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27
 SwitchGear 3'UTR luciferase reporter plasmids for FBXO27
 SwitchGear Promoter luciferase reporter plasmids for FBXO27
 ThermoFisher Antibodies for FBXO27
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO27
 inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO27
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO27
Customized:
 lentivirus for stable overexpression of FBXO27
 lentivirus expression plasmids for stable overexpression of FBXO27
 adenovirus for overexpression of FBXO27
 LSBio Antibodies in human, mouse, rat for FBXO27
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      FBXO27 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4