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Aliases for FBXO27 Gene

Aliases for FBXO27 Gene

  • F-Box Protein 27 2 3 5
  • F-Box/G-Domain Protein 5 3 4
  • F-Box Only Protein 27 2 3
  • Fbx27 3 4
  • FBG5 3 4
  • F-Box Protein FBG5 3

External Ids for FBXO27 Gene

Previous GeneCards Identifiers for FBXO27 Gene

  • GC19M040127
  • GC19M039905
  • GC19M044190
  • GC19M044206
  • GC19M039516
  • GC19M035961
  • GC19M039483

Summaries for FBXO27 Gene

Entrez Gene Summary for FBXO27 Gene

  • Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO27 Gene

FBXO27 (F-Box Protein 27) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO17.

UniProtKB/Swiss-Prot for FBXO27 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO27 Gene

Genomics for FBXO27 Gene

Regulatory Elements for FBXO27 Gene

Enhancers for FBXO27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F039029 1.1 ENCODE 78.7 +0.7 742 4.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF416 FBXO27 ENSG00000269069 FBL ENSG00000266963 RPS16 ENSG00000269172 ENSG00000267375 LOC105372399 ENSG00000269445 ENSG00000269792
GH19F039038 1 Ensembl ENCODE 77.7 -5.6 -5616 0.4 ZNF263 CTCF ZNF654 SP3 ZFP37 CEBPB REST RAD21 YY1 ZNF121 FBXO27 GC19M039038
GH19F039045 0.9 ENCODE 74.3 -13.5 -13478 1.4 TBP HDAC1 PKNOX1 BMI1 ZBTB40 GATA2 CREM SMARCA5 ZNF280D SP3 FBXO27 SUPT5H GC19M039038 GC19P039085
GH19F038988 1.3 Ensembl ENCODE 47.3 +43.6 43639 0.9 HDGF SIN3A FEZF1 ZNF2 ZNF121 GLIS2 KLF7 ZNF263 SP3 TSHZ1 FBXO27 ENSG00000266963 ENSG00000269172 ENSG00000267375 ENSG00000269445 LOC105372399 ENSG00000269792 LGALS14 ENSG00000269188 LOC100129935
GH19F039052 0.9 ENCODE 62.8 -20.7 -20708 2.3 MLX ZNF493 ZNF48 ZNF2 ZNF121 ZNF143 SP3 YY2 SP5 REST FBXO27 ENSG00000266963 ENSG00000269069 ENSG00000269172 ENSG00000267375 ENSG00000269792 LOC105372399 ENSG00000269445 ENSG00000269188 LGALS14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO27 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346418 885 1801 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF207

Genomic Location for FBXO27 Gene

38,990,714 bp from pter
39,032,785 bp from pter
42,072 bases
Minus strand

Genomic View for FBXO27 Gene

Genes around FBXO27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO27 Gene

Proteins for FBXO27 Gene

  • Protein details for FBXO27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 27
    Protein Accession:
    Secondary Accessions:
    • Q96C87

    Protein attributes for FBXO27 Gene

    283 amino acids
    Molecular mass:
    31623 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.

neXtProt entry for FBXO27 Gene

Post-translational modifications for FBXO27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO27 Gene

No data available for DME Specific Peptides for FBXO27 Gene

Domains & Families for FBXO27 Gene

Gene Families for FBXO27 Gene

Protein Domains for FBXO27 Gene

Suggested Antigen Peptide Sequences for FBXO27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
  • Contains 1 FBA (F-box associated) domain.
genes like me logo Genes that share domains with FBXO27: view

Function for FBXO27 Gene

Molecular function for FBXO27 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.

Gene Ontology (GO) - Molecular Function for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IDA 18203720
GO:0005515 protein binding IPI 18203720
genes like me logo Genes that share ontologies with FBXO27: view
genes like me logo Genes that share phenotypes with FBXO27: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO27 Gene

Localization for FBXO27 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO27 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 18203720
genes like me logo Genes that share ontologies with FBXO27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO27 Gene

Pathways & Interactions for FBXO27 Gene

genes like me logo Genes that share pathways with FBXO27: view

Gene Ontology (GO) - Biological Process for FBXO27 Gene


No data available for SIGNOR curated interactions for FBXO27 Gene

Transcripts for FBXO27 Gene

Unigene Clusters for FBXO27 Gene

F-box protein 27:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO27 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -

Relevant External Links for FBXO27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO27 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO27 Gene:


SOURCE GeneReport for Unigene cluster for FBXO27 Gene:


mRNA Expression by UniProt/SwissProt for FBXO27 Gene:

Tissue specificity: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung.
genes like me logo Genes that share expression patterns with FBXO27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FBXO27 Gene

Orthologs for FBXO27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXO27 35
  • 100 (a)
(Canis familiaris)
Mammalia FBXO27 34 35
  • 89.37 (n)
(Mus musculus)
Mammalia Fbxo27 34 16 35
  • 82 (n)
(Rattus norvegicus)
Mammalia Fbxo27 34
  • 81.11 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
-- 35
  • 55 (a)
(Bos Taurus)
Mammalia -- 35
  • 49 (a)
-- 35
  • 45 (a)
-- 35
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo27 34
  • 53.08 (n)
Species where no ortholog for FBXO27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO27 Gene

Gene Tree for FBXO27 (if available)
Gene Tree for FBXO27 (if available)

Paralogs for FBXO27 Gene

Paralogs for FBXO27 Gene

(5) SIMAP similar genes for FBXO27 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXO27: view

Variants for FBXO27 Gene

Sequence variations from dbSNP and Humsavar for FBXO27 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402088 -- 39,012,128(+) acgcc(C/T)ggccG intron-variant
rs10406380 -- 39,010,473(+) ctctc(C/T)ttatg intron-variant
rs10407139 -- 39,033,686(+) cctgc(C/T)gtgac upstream-variant-2KB
rs10407438 -- 39,033,903(+) ataaa(A/G)cattt upstream-variant-2KB
rs10410965 -- 39,007,558(+) gaaag(A/G)cagag intron-variant

Variation tolerance for FBXO27 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FBXO27 Gene

Disorders for FBXO27 Gene

Relevant External Links for FBXO27

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO27 Gene

Publications for FBXO27 Gene

  1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 22 64
  2. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PMID: 126433) Bauters F. … Goudemand M. (Nouv Rev Fr Hematol 1975) 2 3 64
  5. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3 64

Products for FBXO27 Gene

Sources for FBXO27 Gene

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