FBXO27 Gene

Aliases
for FBXO27 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19M040127 GC19M039905 GC19M044190 GC19M044206 GC19M039516 GC19M035961

Summaries
for FBXO27 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for FBXO27 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NT_011109.17  NC_018930.2  

SwitchGear Promoter luciferase reporter plasmid: FBXO27 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO27

FBXO27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039483:  view genomic region     (about GC identifiers)

Proteins
for FBXO27 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for FBXO27: NX_Q8NI29

Explore proteomics data for FBXO27 at MOPED


See FBXO27 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

FBXO27 Human Recombinant Protein Products:

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	antibodies-online proteins for FBXO27 (6 products)
	antibodies-online peptides for FBXO27

FBXO27 Antibody Products:

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FBXO27 Assay Products:

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	antibodies-online kits for FBXO27 (16 products)

Domains /
Families
for FBXO27 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8NI29

Find genes that share domains with FBXO27           About GenesLikeMe

Function
for FBXO27 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for FBXO27

miRNA Products:		Block miRNA regulation of human, mouse, rat FBXO27 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate FBXO27 (see all 17):
		hsa-miR-1321 hsa-miR-185* hsa-miR-15a hsa-miR-124 hsa-miR-424 hsa-miR-506 hsa-miR-556-3p hsa-miR-195
		SwitchGear 3'UTR luciferase reporter plasmid: FBXO27 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for FBXO27
		Predesigned siRNA for gene silencing in human, mouse, rat FBXO27

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for FBXO27

Clone Products:		OriGene clones in human, mouse for FBXO27 (see all 8) OriGene ORF clones in mouse, rat for FBXO27 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: FBXO27 (NM_178820)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO27
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO27

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FBXO27
		Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO27

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27

Localization
for FBXO27 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	2
nucleus	2
extracellular	1
peroxisome	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for FBXO27 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for FBXO27 About     See pathways by source

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	SuperPath	Contained pathways About
1	Class I MHC mediated antigen processing and presentation	Antigen processing- Ubiquitination and Proteasome degradation 0.84 Adaptive Immune System 0.41 Class I MHC mediated antigen processing and presentation 0.84

1 Reactome Pathway for FBXO27

Antigen processing: Ubiquitination & Proteasome degradation

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for FBXO27 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for FBXO27 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for FBXO27 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FBXO27 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for FBXO27 OriGene qSTAR qPCR primer pairs in human, mouse for FBXO27
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO27
		QuantiTect SYBR Green Assays in human, mouse, rat FBXO27
		QuantiFast Probe-based Assays in human, mouse, rat FBXO27

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO27

Orthologs
for FBXO27 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for FBXO27 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for FBXO27 gene

FBXO17²  FBXO6²  FBXO2²  FBXO44²  NCCRP1²  

5 SIMAP similar genes for FBXO27 using alignment to 4 protein entries:     FBX27_HUMAN (see all proteins):

FBXO17    ETFA    FBXO2    FBXO44    FBXO6

Find genes that share paralogs with FBXO27           About GenesLikeMe

Genomic Variants
for FBXO27 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FBXO27 (see all 286)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs72598001,2	C,F	--	35961350(+)	CATGCT/GTTTCT	1	--	int1		2		WA NA	238
rs65088391,2	C,F,A,H	--	35961460(+)	ACGGAA/GTCTCG	1	--	int1		9		NA WA EA	372
rs1412471661,2		--	35961464(+)	AGTCTC/TGCTCT	1	--	int1		0	--	--	--	--
rs1872376021,2		--	35961465(+)	GTCTCA/GCTCTT	1	--	int1		0	--	--	--	--
rs1508102151,2		--	35961472(+)	TCTTTC/TGCCCA	1	--	int1		0	--	--	--	--
rs1394003761,2		--	35961487(+)	GGAGCA/GCAGTG	1	--	int1		0	--	--	--	--
rs72589971,2	C	--	35961508(+)	GGCTCA/TCTGCA	1	--	int1		0	--	--	--	--
rs65088401,2	C,F,A,H	--	35961558(+)	CCTCCT/CGAGTA	1	--	int1		5		NA WA	10
rs1894073191,2	C	--	35961574(+)	GATTAC/TAGGCG	1	--	int1		0	--	--	--	--
rs1397981261,2		--	35961588(+)	GCCACC/TATGCC	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for FBXO27 (39481354 - 39523425 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for FBXO27: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing FBXO27

DNA2.0 Custom Variant and Variant Library Synthesis for FBXO27

Disorders / Diseases
for FBXO27 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for FBXO27 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)^{1, 2, 9} Ilyin G.P....Guguen-Guillouzo C. (Gene 2002)
2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)^{1, 2, 9} Glenn K.A.... Paulson H.L. (J. Biol. Chem. 2008)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. [Clinical conference: Thrombocythemic introduction to chronic myeloid leukemia]. (PubMed id 126433)^{1, 3} Bauters F. and Goudemand M. (Nouv Rev Fr Hematol 1975)
5. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)¹ Scifo E....Lalowski M. (J. Proteome Res. 2013)
6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)¹ Taipale M....Lindquist S. (Cell 2012)
7. Skp1 stabilizes the conformation of F-box proteins. (PubMed id 21640084)¹ Yoshida Y....Tanaka K. (Biochem. Biophys. Res. Commun. 2011)
8. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)⁴ Paterson A.D....Bull S.B. (Diabetes 2010)
9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (EMBO J. 2009)
10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)

External Searches for FBXO27 gene

Genome Databases showing FBXO27 gene

Other Databases showing FBXO27 gene

Specialized Databases showing FBXO27 gene

Products
for FBXO27 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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