Aliases for FBXO25 Gene
Aliases for FBXO25 Gene
External Ids for FBXO25 Gene
- HGNC: 13596
- Entrez Gene: 26260
- Ensembl: ENSG00000147364
- OMIM: 609098
- UniProtKB: Q8TCJ0
Previous GeneCards Identifiers for FBXO25 Gene
- GC08P000253
- GC08P000396
- GC08P000509
- GC08P000353
- GC08P000200
Summaries for FBXO25 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXO25 Gene
FBXO25 (F-Box Protein 25) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. GO annotations related to this gene include actin binding and ubiquitin-protein transferase activity. An important paralog of this gene is FBXO32.
UniProtKB/Swiss-Prot for FBXO25 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO25 Gene
Genomics for FBXO25 Gene
Regulatory Elements for FBXO25 Gene
Enhancers for FBXO25 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G000460 | 0.9 | Ensembl ENCODE | 10.4 | +55.6 | 55646 | 2.5 | RNF2 BHLHE40 CEBPG JUND SMARCA4 ZNF341 FOS HNF4A MAFK NFE2L2 | LOC105377773 FBXO25 GC08M000451 GC08P000470 PIR47185 |
| GH08G000399 | 1.1 | ENCODE dbSUPER | 5.5 | -5.5 | -5456 | 2.2 | ELF3 FOXA2 ARID4B YBX1 RARA ZEB1 SCRT2 MIXL1 EGR2 ZIK1 | ENSG00000273402 ZNF596 TDRP ENSG00000272240 ENSG00000272812 FBXO25 GC08M000366 |
| GH08G000381 | 0.4 | ENCODE | 4.7 | -23.8 | -23754 | 2.2 | ETV1 ZNF48 | LOC105377773 RPL23AP53 FBXO25 FAM87A |
| GH08G000836 | 0.5 | FANTOM5 | 2.6 | +430.2 | 430249 | 0.1 | NR2C1 NR2C2 | FBXO25 GC08P000867 LOC401442 |
| GH08G000406 | 1.2 | ENCODE dbSUPER | 0.7 | +0.5 | 516 | 1.2 | ATF1 ARID4B SIN3A GLI4 ZNF48 ZNF121 GLIS2 ELK1 ZNF143 SP3 | FBXO25 GC08P000416 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO25 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXO25 Gene
- Chromosome:
- 8
- Start:
- 406,428 bp from pter
- End:
- 477,967 bp from pter
- Size:
- 71,540 bases
- Orientation:
- Plus strand
Genomic View for FBXO25 Gene
Genes around FBXO25 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p23.3 by Ensembl
- 8p23.3 by Entrez Gene
- 8p23.3 by HGNC
FBXO25 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO25 Gene
Proteins for FBXO25 Gene
-
Protein details for FBXO25 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TCJ0-FBX25_HUMAN
- Recommended name:
- F-box only protein 25
- Protein Accession:
- Q8TCJ0
- Q6PJ83
- Q7Z4V4
- Q9UKB8
Protein attributes for FBXO25 Gene
- Size:
- 367 amino acids
- Molecular mass:
- 43313 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).
Protein Expression for FBXO25 Gene
Post-translational modifications for FBXO25 Gene
Other Protein References for FBXO25 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXO25
- Invitrogen Antibodies for FBXO25
- antibodies-online Antibodies for FBXO25: See all 28
- GeneTex FBXO25 antibody for FBXO25
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXO25
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXO25
- Origene Custom Protein Services for FBXO25
- antibodies-online Proteins for FBXO25: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO25
Assay Products
- antibodies-online Kits for FBXO25: See all 15
No data available for DME Specific Peptides for FBXO25 Gene
Domains & Families for FBXO25 Gene
Gene Families for FBXO25 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FBXO25 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TCJ0- Domain:
-
- The F-box is necessary for the interaction with SKP1.
Function for FBXO25 Gene
Molecular function for FBXO25 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | NAS | 10531035 |
Phenotypes for FBXO25 Gene
- GenomeRNAi human phenotypes for FBXO25:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO25 gene
-
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- Search ViGene Biosciences for FBXO25
CRISPR Products
-
OriGene CRISPR knockouts for FBXO25
-
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miRNA for FBXO25 Gene
- miRTarBase miRNAs that target FBXO25
miRNA Products
- Search ViGene Biosciences for FBXO25
Inhibitory RNA Products
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-
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Cell Line Products
-
Horizon Cell Lines for FBXO25
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO25 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO25 Gene
Localization for FBXO25 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXO25 Gene
- Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | NAS | 10531035 |
| GO:0005634 | nucleus | IDA,ISS | -- |
| GO:0005730 | NOT nucleolus | IDA | 16278047 |
| GO:0019005 | SCF ubiquitin ligase complex | ISS | -- |
Pathways & Interactions for FBXO25 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FoxO signaling pathway | ||
Pathways by source for FBXO25 Gene
1 KEGG pathway for FBXO25 Gene
UniProtKB/Swiss-Prot Q8TCJ0-FBX25_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXO25 Gene
Selected Interacting proteins:
ENSP00000276326
Q8TCJ0-FBX25_HUMAN
for FBXO25 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | NAS | 10531035 |
No data available for SIGNOR curated interactions for FBXO25 Gene
Transcripts for FBXO25 Gene
mRNA/cDNA for FBXO25 Gene
- (7) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (191) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO25
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO25
- GenScript: Design CRISPR guide RNA sequences for FBXO25
miRNA Products
- Search ViGene Biosciences for FBXO25
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO25
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO25 gene
Clone Products
- Sino Biological Human cDNA Clone for FBXO25
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for FBXO25 Gene
mRNA differential expression in normal tissues according to GTEx for FBXO25 Gene
This gene is overexpressed in Testis (x5.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO25 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO25 Gene:
FBXO25SOURCE GeneReport for Unigene cluster for FBXO25 Gene:
Hs.438454mRNA Expression by UniProt/SwissProt for FBXO25 Gene:
Q8TCJ0-FBX25_HUMAN
Tissue specificity:
Expressed in all brain tissue observed.
Evidence on tissue expression from TISSUES for FBXO25 Gene
- Nervous system(4.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXO25
-
OriGene qPCR primer pairs for FBXO25
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO25 Gene
Orthologs for FBXO25 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO25 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO25 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO25 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FBXO25 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO25 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo25 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo25 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | FBXO25 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO25 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo25 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo25 34 35 |
|
||
| Dr.16139 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012127 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11658 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mfb-1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for FBXO25 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FBXO25 Gene
(1) SIMAP similar genes for FBXO25 Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for FBXO25 Gene
Variants for FBXO25 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004420 | -- | 469,836(+) | TTCCT(G/T)TAAGC | utr-variant-3-prime | |
| rs1000019438 | -- | 454,599(+) | TGGAG(C/G)TTAAA | intron-variant | |
| rs1000025450 | -- | 463,405(+) | GGCGG(A/C)TTGCA | intron-variant | |
| rs1000119633 | -- | 405,605(+) | TAAAC(C/T)TCTAA | upstream-variant-2KB | |
| rs1000123442 | -- | 441,443(+) | ATTCA(A/G)GACAT | intron-variant |
Residual Variation Intolerance Score:
36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.87;
79.43% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO25 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO25
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO25 Gene
Disorders for FBXO25 Gene
UniProtKB/Swiss-Prot
FBX25_HUMAN- Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
Relevant External Links for FBXO25
No disorders were found for FBXO25 Gene.
No data available for MalaCards and Genatlas for FBXO25 Gene
Publications for FBXO25 Gene
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
- Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PMID: 20473970) Teixeira F.R. … Gomes M.D. (Proteomics 2010) 3 4 64
- FBXO25-associated nuclear domains: a novel subnuclear structure. (PMID: 18287534) Manfiolli A.O. … Gomes M.D. (Mol. Biol. Cell 2008) 3 4 64
- Characterization of FBX25, encoding a novel brain-expressed F-box protein. (PMID: 16278047) Hagens O. … Kalscheuer V. (Biochim. Biophys. Acta 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for FBXO25 Gene
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- GenScript: Design CRISPR guide RNA sequences for FBXO25
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- Novus Biologicals Antibodies for FBXO25
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FBXO25: See all 28
- antibodies-online Kits for FBXO25: See all 15
- antibodies-online Proteins for FBXO25: See all 7
- Search antibodies-online for peptides
- GeneTex FBXO25 antibody for FBXO25
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- ViGene Biosciences adenoviral particle packaged cDNA for FBXO25 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXO25 gene
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- VectorBuilder custom plasmid, inducible vectors for FBXO25
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO25 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer