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Aliases for FBXO25 Gene

Aliases for FBXO25 Gene

  • F-Box Protein 25 2 3
  • FBX25 3 4 6
  • F-Box Only Protein 25 2 3
  • F-Box Protein Fbx25 3

External Ids for FBXO25 Gene

Previous GeneCards Identifiers for FBXO25 Gene

  • GC08P000253
  • GC08P000396
  • GC08P000509
  • GC08P000353
  • GC08P000200

Summaries for FBXO25 Gene

Entrez Gene Summary for FBXO25 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO25 Gene

FBXO25 (F-Box Protein 25) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. GO annotations related to this gene include actin binding and ubiquitin-protein transferase activity. An important paralog of this gene is FBXO32.

UniProtKB/Swiss-Prot for FBXO25 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO25 Gene

Genomics for FBXO25 Gene

Genomic Location for FBXO25 Gene

406,428 bp from pter
477,967 bp from pter
71,540 bases
Plus strand

Genomic View for FBXO25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO25 Gene

No data available for Regulatory Elements for FBXO25 Gene

Proteins for FBXO25 Gene

  • Protein details for FBXO25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 25
    Protein Accession:
    Secondary Accessions:
    • Q6PJ83
    • Q7Z4V4
    • Q9UKB8

    Protein attributes for FBXO25 Gene

    367 amino acids
    Molecular mass:
    43313 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).

    Alternative splice isoforms for FBXO25 Gene


neXtProt entry for FBXO25 Gene

Proteomics data for FBXO25 Gene at MOPED

Post-translational modifications for FBXO25 Gene

  • Ubiquitination at Lys17 and Lys146
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO25 Gene

Antibody Products

No data available for DME Specific Peptides for FBXO25 Gene

Domains for FBXO25 Gene

Gene Families for FBXO25 Gene

Protein Domains for FBXO25 Gene


Suggested Antigen Peptide Sequences for FBXO25 Gene

Graphical View of Domain Structure for InterPro Entry



  • The F-box is necessary for the interaction with SKP1.
  • The F-box is necessary for the interaction with SKP1.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO25: view

Function for FBXO25 Gene

Molecular function for FBXO25 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).

Gene Ontology (GO) - Molecular Function for FBXO25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 20473970
genes like me logo Genes that share ontologies with FBXO25: view

Animal Model Products

miRNA for FBXO25 Gene

miRTarBase miRNAs that target FBXO25

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO25 Gene

Localization for FBXO25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO25 Gene

Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.

Subcellular locations from

Jensen Localization Image for FBXO25 Gene COMPARTMENTS Subcellular localization image for FBXO25 gene
Compartment Confidence
nucleus 5
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for FBXO25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005730 NOT nucleolus IDA 16278047
GO:0019005 SCF ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with FBXO25: view

Pathways for FBXO25 Gene

SuperPathways for FBXO25 Gene

Superpath Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with FBXO25: view

Pathways by source for FBXO25 Gene

1 KEGG pathway for FBXO25 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8TCJ0-FBX25_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
genes like me logo Genes that share ontologies with FBXO25: view

Transcripts for FBXO25 Gene

Unigene Clusters for FBXO25 Gene

F-box protein 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO25 Gene

No ASD Table

Relevant External Links for FBXO25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO25 Gene

mRNA expression in normal human tissues for FBXO25 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO25 Gene

This gene is overexpressed in Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO25 Gene

SOURCE GeneReport for Unigene cluster for FBXO25 Gene Hs.438454

mRNA Expression by UniProt/SwissProt for FBXO25 Gene

Tissue specificity: Expressed in all brain tissue observed.
genes like me logo Genes that share expressions with FBXO25: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Expression partners for FBXO25 Gene

Orthologs for FBXO25 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO25 35
  • 85.43 (n)
  • 90.2 (a)
FBXO25 36
  • 90 (a)
(Canis familiaris)
Mammalia FBXO25 35
  • 84.47 (n)
  • 91.55 (a)
FBXO25 36
  • 92 (a)
(Mus musculus)
Mammalia Fbxo25 35
  • 83.29 (n)
  • 88.8 (a)
Fbxo25 16
Fbxo25 36
  • 89 (a)
(Pan troglodytes)
Mammalia FBXO25 35
  • 99.73 (n)
  • 99.73 (a)
FBXO25 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo25 35
  • 84.22 (n)
  • 88.8 (a)
(Monodelphis domestica)
Mammalia FBXO25 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO25 36
  • 86 (a)
(Gallus gallus)
Aves FBXO25 35
  • 80.47 (n)
  • 84.74 (a)
FBXO25 36
  • 84 (a)
(Anolis carolinensis)
Reptilia FBXO25 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo25 35
  • 70.82 (n)
  • 71.67 (a)
(Danio rerio)
Actinopterygii Dr.16139 35
fbxo25 35
  • 71.35 (n)
  • 76.97 (a)
fbxo25 36
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012127 35
  • 46.44 (n)
  • 34.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11658 35
  • 41.92 (n)
  • 29.45 (a)
CG11658 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea mfb-1 35
  • 42.93 (n)
  • 33.53 (a)
mfb-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for FBXO25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO25 Gene

Gene Tree for FBXO25 (if available)
Gene Tree for FBXO25 (if available)

Paralogs for FBXO25 Gene

Paralogs for FBXO25 Gene

(1) SIMAP similar genes for FBXO25 Gene using alignment to 3 proteins: Pseudogenes for FBXO25 Gene

genes like me logo Genes that share paralogs with FBXO25: view

Variants for FBXO25 Gene

Sequence variations from dbSNP and Humsavar for FBXO25 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1090 -- 452,108(+) CACTG(C/G)TAAGA intron-variant
rs880926 -- 439,450(+) TTTAT(A/G)TATCT intron-variant
rs935555 -- 423,147(+) TTGGG(A/G)CTACA intron-variant
rs1448090 -- 410,700(-) ACATC(C/T)TAAAA intron-variant
rs1530662 -- 452,692(+) TTTCT(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO25 Gene

Variant ID Type Subtype PubMed ID
dgv2169e1 CNV Complex 17122850
nsv465263 CNV Gain 19166990
nsv524542 CNV Gain 19592680
nsv470163 CNV Loss 18288195
nsv465264 CNV Loss 19166990
dgv2170e1 CNV Complex 17122850
nsv470164 CNV Gain 18288195
dgv240e55 CNV Gain 17911159
nsv889668 CNV Gain 21882294
nsv889669 CNV Loss 21882294
essv6400 CNV CNV 17122850
nsv889670 CNV Gain 21882294
nsv527388 CNV Gain 19592680
esv27875 CNV Loss 19812545
nsv471483 CNV Duplication 19718026
nsv8257 CNV Gain 18304495
nsv889671 CNV Gain 21882294
dgv7583n71 CNV Gain 21882294
nsv8259 CNV Gain 18304495
esv1419160 CNV Insertion 17803354

Relevant External Links for FBXO25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO25 Gene

Disorders for FBXO25 Gene


  • Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.

Relevant External Links for FBXO25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FBXO25 Gene.

No data available for MalaCards , OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FBXO25 Gene

Publications for FBXO25 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of FBX25, encoding a novel brain-expressed F-box protein. (PMID: 16278047) Hagens O. … Kalscheuer V. (Biochim. Biophys. Acta 2006) 3 4
  5. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PMID: 20473970) Teixeira F.R. … Gomes M.D. (Proteomics 2010) 3 4

Products for FBXO25 Gene

Sources for FBXO25 Gene

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