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FBXO25 Gene

protein-coding   GIFtS: 50
GCID: GC08P000346

F-Box Protein 25

(Previous name: F-box only protein 25)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 251 2
FBX252 3 5
F-Box Only Protein 251 2
F-Box Protein Fbx252

External Ids:    HGNC: 135961   Entrez Gene: 262602   Ensembl: ENSG000001473647   OMIM: 6090985   UniProtKB: Q8TCJ03   

Export aliases for FBXO25 gene to outside databases

Previous GC identifers: GC08P000253 GC08P000396 GC08P000509 GC08P000353 GC08P000200


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO25 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO25 Gene:
FBXO25 (F-box protein 25) is a protein-coding gene. Diseases associated with FBXO25 include mental retardation, and multiple myeloma. GO annotations related to this gene include ubiquitin-protein ligase activity and actin binding. An important paralog of this gene is FBXO32.

UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_023736.18  NC_018919.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for FBXO25
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO25 promoter sequence
   Search Chromatin IP Primers for FBXO25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.3   Ensembl cytogenetic band:  8p23.3   HGNC cytogenetic band: 8p23.3

FBXO25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO25 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P000346:  view genomic region     (about GC identifiers)

Start:
356,428 bp from pter      End:
421,225 bp from pter
Size:
64,798 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0 (See protein sequence)
Recommended Name: F-box only protein 25  
Size: 367 amino acids; 43313 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1.
Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus)
Secondary accessions: Q6PJ83 Q7Z4V4 Q9UKB8
Alternative splicing: 3 isoforms:  Q8TCJ0-1   Q8TCJ0-2   Q8TCJ0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO25: NX_Q8TCJ0

Explore proteomics data for FBXO25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17, Lys146
  • Modification sites at PhosphoSitePlus

  • See FBXO25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_036305.2  NP_904356.1  NP_904357.1  

    ENSEMBL proteins: 
     ENSP00000428872   ENSP00000342077   ENSP00000276326   ENSP00000372274   ENSP00000430191  
     ENSP00000341345  

    FBXO25 Human Recombinant Protein Products:

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    Novus Biologicals FBXO25 Protein
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    Cloud-Clone Corp. Proteins for FBXO25

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    Cloud-Clone Corp. CLIAs for FBXO25


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q8TCJ0

    ProtoNet protein and cluster: Q8TCJ0

    UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0
    Domain: The F-box is necessary for the interaction with SKP1 (By similarity)
    Similarity: Contains 1 F-box domain


    FBXO25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX25_HUMAN, Q8TCJ0
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
    May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI--
         
    FBXO25 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO25
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO25

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO25
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO25

    miRNA
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    miRTarBase miRNAs that target FBXO25:
    hsa-mir-215-5p (MIRT024524), hsa-mir-192-5p (MIRT026896)

    Block miRNA regulation of human, mouse, rat FBXO25 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FBXO25:
    hsa-miR-34c-3p hsa-miR-577 hsa-miR-34b hsa-miR-556-3p hsa-miR-624 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidFBXO25 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO25

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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXO25 (NM_012173)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO25


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX25_HUMAN, Q8TCJ0: Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized
    with SKP1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA16278047
    GO:0019005SCF ubiquitin ligase complex ISS--

    FBXO25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXO25 About    
    See pathways by source

    SuperPathContained pathways About
    1FoxO signaling pathway
    FoxO signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for FBXO25):
        FoxO signaling pathway

    UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0
    Pathway: Protein modification; protein ubiquitination


    FBXO25 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO25: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO25 (Q8TCJ01, 3 ENSP000002763264) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136163, ENSP000003268044I2D: score=3 STRING: ENSP00000326804
    SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
    ACTBP607091, ENSP000003499604EBI-6264551,EBI-353944 STRING: ENSP00000349960
    BTRCENSP000003592064STRING: ENSP00000359206
    CCNFENSP000003802564STRING: ENSP00000380256
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035

    FBXO25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO25 (FBX25)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXO25 gene (3 alternative transcripts): 
    NM_012173.3  NM_183420.1  NM_183421.1  

    Unigene Cluster for FBXO25:

    F-box protein 25
    Hs.438454  [show with all ESTs]
    Unigene Representative Sequence: NM_183421
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518240 ENST00000350302 ENST00000276326(uc003wpa.3) ENST00000382824
    ENST00000524125 ENST00000524015 ENST00000519376 ENST00000517464 ENST00000519274
    ENST00000352684(uc003wox.3 uc003woy.3 uc003woz.3)
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate FBXO25:
    hsa-miR-34c-3p hsa-miR-577 hsa-miR-34b hsa-miR-556-3p hsa-miR-624 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidFBXO25 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): FBXO25 (NM_012173)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO25
    Primer
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    OriGene qPCR primer pairs and template standards for FBXO25
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO25
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO25
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO25
      QuantiFast Probe-based Assays in human, mouse, rat FBXO25

    Additional mRNA sequence: 

    AB070270.1 AF174605.1 AF419858.1 AK302334.1 BC012143.2 BC020249.2 BC035555.1 BC050393.1 

    12 DOTS entries:

    DT.75143531  DT.92045942  DT.100702723  DT.100783324  DT.92004230  DT.100783320  DT.121476789  DT.121476799 
    DT.95071266  DT.97797574  DT.86835953  DT.97796541 

    Selected AceView cDNA sequences (see all 191):

    CR596773 CD370702 NM_183420 BM784011 BM698939 AA463859 AI640599 BU730882 
    BU674770 BI092692 AW247831 AW771959 AA905852 AA620870 AA282252 BX350356 
    BQ774688 AA506009 BE671777 BM850494 BM692844 BM671416 AI271464 AF419858 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGCATTTT
    FBXO25 Expression
    About this image

    FBXO25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438454

    UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0
    Tissue specificity: Expressed in all brain tissue observed

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO25: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXO25 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo251 , 5 F-box protein 251, 5 83.29(n)1
    88.8(a)1
      8 (6.42 cM)5
    668221  NM_025785.21  NP_080061.11 
     139078065 
    chicken
    (Gallus gallus)
    Aves FBXO251 F-box protein 25 80.47(n)
    84.74(a)
      421906  XM_004940489.1  XP_004940546.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO256
    F-box protein 25
    86(a)
    1 ↔ 1
    1(159719802-159767479)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo251 F-box protein 25 70.82(n)
    71.67(a)
      595094  NM_001030531.1  NP_001025702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.161392 Danio rerio clone RK136A1E06 F-box only protein 25 more 78.05(n)    AY398345.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116581 CG11658 41.92(n)
    29.45(a)
      39319  NM_206336.2  NP_996058.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mfb-11 mfb-1 42.93(n)
    33.53(a)
      183975  NM_059975.4  NP_492376.1 


    ENSEMBL Gene Tree for FBXO25 (if available)
    TreeFam Gene Tree for FBXO25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO25 gene
    FBXO322  
    1 SIMAP similar gene for FBXO25 using alignment to 3 protein entries:     FBX25_HUMAN (see all proteins):
    FBXO32

    FBXO25 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FBXO25
    PGOHUM00000243874 PGOHUM00000244452 PGOHUM00000241159


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO25 (see all 2005)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78273251,2
    C,F--354843(+) GCTATC/TACACT 3 -- us2k110Minor allele frequency- T:0.42NA WA CSA EA 371
    rs1880623991,2
    --354922(+) CTGATA/GTTACA 3 -- us2k10--------
    rs1915297531,2
    --355040(+) TACCTC/TTTTAC 3 -- us2k10--------
    rs50089291,2
    C--355088(+) ATGCTA/GGCCAA 3 -- us2k12Minor allele frequency- G:0.00NA 4
    rs1442473401,2
    --355094(+) GCCAAC/TTGGGC 3 -- us2k10--------
    rs1113145881,2
    C--355210(+) AATAAA/CATTTC 3 -- us2k12Minor allele frequency- C:0.13NA EA 122
    rs1833609511,2
    --355430(+) CTGTAC/GTCTAA 3 -- us2k10--------
    rs1414892231,2
    C--355474(+) ATAGCC/GTACTC 3 -- us2k10--------
    rs1888191401,2
    --355497(+) CCTCCA/TACCGG 3 -- us2k10--------
    rs1924679401,2
    C--355500(+) CCTACA/CGGCGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXO25 (356428 - 421225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FBXO25 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471483CNV Duplication19718026
    esv1419160CNV Insertion17803354
    nsv470163CNV Loss18288195
    nsv465264CNV Loss19166990
    nsv889669CNV Loss21882294
    esv27875CNV Loss19812545
    nsv470164CNV Gain18288195
    nsv889668CNV Gain21882294
    nsv8257CNV Gain18304495
    nsv8259CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO25
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609098    OMIM disorders: --

    UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0
  • Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR).
    Translocation t(X;8)(p11.22;p23.3) with SHROOM4

  • 3 diseases for FBXO25:    
    About MalaCards
    mental retardation    multiple myeloma    myeloma


    FBXO25 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO25
    Human Genome Epidemiology (HuGE) Navigator: FBXO25 (1 document)

    Export disorders for FBXO25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO25 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with FBXO25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1, 2 Teixeira F.R.... Gomes M.D. (Proteomics 2010)
    3. FBXO25-associated nuclear domains: a novel subnuclear structure. (PubMed id 18287534)1, 2 Manfiolli A.O.... Gomes M.D. (Mol. Biol. Cell 2008)
    4. Characterization of FBX25, encoding a novel brain-expressed F-box protein. (PubMed id 16278047)1, 2 Hagens O.... Kalscheuer V. (Biochim. Biophys. Acta 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    7. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26260 HGNC: 13596 AceView: FBXO25 Ensembl:ENSG00000147364 euGenes: HUgn26260
    ECgene: FBXO25 Kegg: 26260 H-InvDB: FBXO25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO25 gene:
    Search GeneIP for patents involving FBXO25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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