FBXO25 Gene
protein-coding GIFtS: 44
GCID: GC08P000346
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|
F-box protein 25(Previous name: F-box only protein 25 )
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Aliases
for FBXO25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box Protein 251 2 | | FBX251 2 3 5 | | F-Box Only Protein 251 2 | | F-Box Protein Fbx252 |
Export aliases for FBXO25 gene to outside databasesPrevious GC identifers: GC08P000253 GC08P000396 GC08P000509 GC08P000353 GC08P000200 |
Summaries
for FBXO25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXO25:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxsclass. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity)
|
Genomic Views
for FBXO25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FBXO25
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXO25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.3 Ensembl cytogenetic band: 8p23.3 HGNC cytogenetic band: 8p23.3FBXO25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P000346: view genomic region
(about GC identifiers)
Start:
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356,428 bp from pter |
End:
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421,225 bp from pter |
Size:
|
64,798 bases |
Orientation:
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plus strand |
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Proteins
for FBXO25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0 (See
protein sequence)Recommended Name: F-box only protein 25 Size: 367 amino acids; 43313 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interactsdirectly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus)
Subcellular location: Nucleus. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized withSKP1
Secondary accessions: Q6PJ83 Q7Z4V4 Q9UKB8Alternative splicing: 3 isoforms: Q8TCJ0-1 Q8TCJ0-2 Q8TCJ0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBXO25: NX_Q8TCJ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCJ0
FBXO25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_036305.2 NP_904356.1 NP_904357.1
ENSEMBL proteins: ENSP00000428872 ENSP00000342077 ENSP00000276326 ENSP00000372274 ENSP00000430191 ENSP00000406265 ENSP00000341345
Human Recombinant Protein Products for FBXO25:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
FBXO25 for ontologies About GeneDecksing
FBXO25 Antibody Products:
Assay Products for FBXO25: |
Protein
Domains /
Families
for FBXO25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXO25 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCJ0ProtoNet protein and cluster: Q8TCJ0 UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0Domain: The F-box is necessary for the interaction with SKP1 (By similarity)Similarity: Contains 1 F-box domain |
Function
for FBXO25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FBX25_HUMAN, Q8TCJ0Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FBXO25 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO25 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO25 |
|
Pathways & Interactions
for FBXO25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO25
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/134 Interacting proteins for FBXO25 (Q8TCJ01, 3 ENSP000002763264) via UniProtKB, MINT, STRING, and/or I2D (see all 134) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
FBXO25 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXO25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXO25
Search CenterWatch for drugs/clinical trials and news about FBXO25 / FBX25
|
Transcripts
for FBXO25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXO25 gene (3 alternative transcripts): NM_012173.3 NM_183420.1 NM_183421.1 Unigene Cluster for FBXO25: F-box protein 25 Hs.438454 [show with all ESTs]Unigene Representative Sequence: NM_18342111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000518240 ENST00000350302 ENST00000276326(uc003wpa.3) ENST00000382824
ENST00000524125 ENST00000524015 ENST00000519376 ENST00000517464 ENST00000519274
ENST00000447233 ENST00000352684(uc003wox.3 uc003woy.3 uc003woz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO25 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO25 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AB070270.1 AF174605.1 AF419858.1 AK302334.1 BC012143.2 BC020249.2 BC035555.1 BC050393.1 12 DOTS entries: DT.75143531 DT.92045942 DT.100702723 DT.100783324 DT.92004230 DT.100783320 DT.121476789 DT.121476799 DT.95071266 DT.97797574 DT.86835953 DT.97796541 24/191 AceView cDNA sequences (see all 191): NM_183420 CD370702 BP430918 CB990931 BF511052 BI755510 AI955056 BC035555 NM_012173 AA234414 AA954609 AA234364 CA306248 BQ645994 BG029498 AI492039 AB070270 BM708985 AI370139 BU625582 BI917882 BM745510 BP430569 AA582696
GeneLoc Exon Structure
|
Expression
for FBXO25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXO25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGCATTTT
About this image
See FBXO25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO25
SOURCE GeneReport for Unigene cluster: Hs.438454
UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0Tissue specificity: Expressed in all brain tissue observed
SABiosciences Expression via Pathway-Focused PCR Array including FBXO25:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO25
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO25 |
Orthologs
for FBXO25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXO25 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FBXO251 |
F-box protein 25 |
80.47(n)
84.74(a) |
|
421906 XM_419924.3 XP_419924.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FBXO256 |
-- |
89(a) |
1 ↔ 1 |
1(159720950-159759038) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.161392 |
Danio rerio clone RK136A1E06 F-box only protein 25 more |
78.05(n) |
|
AY398345.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG116586 |
-- |
23(a) |
1 → many |
3L(11692596-11701653) |
worm
(Caenorhabditis elegans) |
Secernentea |
mfb-11 |
Protein MFB-1 |
42.69(n)
32.54(a) |
|
183975 NM_059975.3 NP_492376.1 |
ENSEMBL Gene Tree for FBXO25 (if available)
TreeFam Gene Tree for FBXO25 (if available) |
Paralogs
for FBXO25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXO25 gene
- FBXO322
1 SIMAP similar gene for FBXO25 using alignment to 4 protein entries: FBX25_HUMAN (see all proteins):FBXO32
FBXO25 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for FBXO25
PGOHUM00000243874 PGOHUM00000244452 PGOHUM00000241159
|
Genomic Variants
for FBXO25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXO25 (356428 - 421225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for FBXO25
5 CNVs: 2723 31416 65016 3716 8587 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO25 |
|
Disorders
/ Diseases
for FBXO25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FBXO25 for disorders About MalaCards
FBXO25 for disorders About GeneDecksing
OMIM gene information: 609098
OMIM disorders: --
UniProtKB/Swiss-Prot: FBX25_HUMAN, Q8TCJ0
Note=A chromosomal aberration involving FBXO25 is a cause of X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4
Human Genome Epidemiology (HuGE) Navigator: FBXO25 (1 document)
Export disorders for FBXO25 gene to outside databases
|
Publications
for FBXO25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXO25 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FBXO25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
- Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1, 2 Teixeira F.R.... Gomes M.D. (2010)
- FBXO25-associated nuclear domains: a novel subnuclear structure. (PubMed id 18287534)1, 2 Manfiolli A.O....Gomes M.D. (2008)
- Characterization of FBX25, encoding a novel brain-expressed F-box protein. (PubMed id 16278047)1, 2 Hagens O.... Kalscheuer V. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T....Harper J.W. (1999)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A novel Fbxo25 acts as an E3 ligase for destructing c ardiac specific transcription factors. (PubMed id 21596019)1 Jang J.W....Chung H.M. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
|
External Searches for FBXO25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXO25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXO25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXO25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXO25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXO25 gene:
Search GeneIP for patents involving FBXO25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXO25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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