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Aliases for FBXO24 Gene

Aliases for FBXO24 Gene

  • F-Box Protein 24 2 3 5
  • F-Box Only Protein 24 2 3
  • FBX24 3 4
  • F-Box Protein Fbx24 3

External Ids for FBXO24 Gene

Previous GeneCards Identifiers for FBXO24 Gene

  • GC07P098718
  • GC07P099781
  • GC07P099795
  • GC07P099828
  • GC07P100021
  • GC07P100181
  • GC07P094815

Summaries for FBXO24 Gene

Entrez Gene Summary for FBXO24 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for FBXO24 Gene

FBXO24 (F-Box Protein 24) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO24 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Wiki entry for FBXO24 Gene

Additional gene information for FBXO24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO24 Gene

Genomics for FBXO24 Gene

GeneHancer (GH) Regulatory Elements for FBXO24 Gene

Promoters and enhancers for FBXO24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100581 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 562.2 +0.7 685 5.9 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 FBXO24 LRCH4 ZSCAN25 AP4M1 ZSCAN21 SRRT SAP25 MEPCE PPP1R35 GIGYF1
GH07I100589 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.4 +6.2 6223 1.6 NR2F1 GLIS2 IKZF1 ZBTB33 NR2F6 SMAD4 NFE2 PRDM10 ZBTB12 FBXO24 NYAP1 TSC22D4 C7orf61 LRCH4 PCOLCE PCOLCE-AS1
GH07I100538 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.4 -39.4 -39369 12.6 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 AGFG2 SAP25 PPP1R35 SRRT ZSCAN25 LRCH4 GIGYF1 AP4M1 MEPCE FBXO24
GH07I100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.3 -106.2 -106227 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 ZNF655 GIGYF1 ZNF3 ENSG00000242798 STAG3L5P PILRA
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.1 -150.8 -150783 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXO24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXO24 gene promoter:

Genomic Locations for FBXO24 Gene

Genomic Locations for FBXO24 Gene
chr7:100,583,982-100,601,117
(GRCh38/hg38)
Size:
17,136 bases
Orientation:
Plus strand
chr7:100,181,605-100,198,740
(GRCh37/hg19)

Genomic View for FBXO24 Gene

Genes around FBXO24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO24 Gene

Proteins for FBXO24 Gene

  • Protein details for FBXO24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75426-FBX24_HUMAN
    Recommended name:
    F-box only protein 24
    Protein Accession:
    O75426
    Secondary Accessions:
    • A4D2D4
    • B4DX91
    • B4DY42
    • Q9H0G1

    Protein attributes for FBXO24 Gene

    Size:
    580 amino acids
    Molecular mass:
    64889 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO24 Gene

Post-translational modifications for FBXO24 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FBXO24 Gene

Domains & Families for FBXO24 Gene

Gene Families for FBXO24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO24 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO24: view

No data available for UniProtKB/Swiss-Prot for FBXO24 Gene

Function for FBXO24 Gene

Molecular function for FBXO24 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXO24 Gene

Gene Ontology (GO) - Molecular Function for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with FBXO24: view
genes like me logo Genes that share phenotypes with FBXO24: view

Animal Model Products

CRISPR Products

miRNA for FBXO24 Gene

miRTarBase miRNAs that target FBXO24

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO24 Gene

Localization for FBXO24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO24 gene
Compartment Confidence
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXO24 Gene

Pathways & Interactions for FBXO24 Gene

SuperPathways for FBXO24 Gene

No Data Available

Interacting Proteins for FBXO24 Gene

Gene Ontology (GO) - Biological Process for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO24 Gene

Drugs & Compounds for FBXO24 Gene

No Compound Related Data Available

Transcripts for FBXO24 Gene

Unigene Clusters for FBXO24 Gene

F-box protein 24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - - -
SP3:

Relevant External Links for FBXO24 Gene

GeneLoc Exon Structure for
FBXO24
ECgene alternative splicing isoforms for
FBXO24

Expression for FBXO24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO24 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO24 Gene

This gene is overexpressed in Testis (x34.9).

Protein differential expression in normal tissues from HIPED for FBXO24 Gene

This gene is overexpressed in Pancreatic juice (60.3) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO24 Gene



Protein tissue co-expression partners for FBXO24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO24 Gene:

FBXO24

SOURCE GeneReport for Unigene cluster for FBXO24 Gene:

Hs.283764
genes like me logo Genes that share expression patterns with FBXO24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO24 Gene

Orthologs for FBXO24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO24 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia FBXO24 33 34
  • 89.95 (n)
cow
(Bos Taurus)
Mammalia FBXO24 33 34
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Fbxo24 16 34 33
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo24 33
  • 86.75 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO24 34
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO24 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo24 33
  • 60.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToOne
Species where no ortholog for FBXO24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO24 Gene

ENSEMBL:
Gene Tree for FBXO24 (if available)
TreeFam:
Gene Tree for FBXO24 (if available)

Paralogs for FBXO24 Gene

No data available for Paralogs for FBXO24 Gene

Variants for FBXO24 Gene

Sequence variations from dbSNP and Humsavar for FBXO24 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000083112 -- 100,587,590(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000253922 -- 100,590,493(+) G/A intron_variant
rs1000303269 -- 100,590,720(+) C/T intron_variant
rs1000601810 -- 100,597,616(+) A/G intron_variant
rs1000870684 -- 100,584,604(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO24 Gene

Variant ID Type Subtype PubMed ID
esv2659884 CNV deletion 23128226
esv2734888 CNV deletion 23290073
esv3614300 CNV loss 21293372
nsv476435 CNV novel sequence insertion 20440878
nsv5868 CNV deletion 18451855
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366

Variation tolerance for FBXO24 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXO24 Gene

Human Gene Mutation Database (HGMD)
FBXO24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO24 Gene

Disorders for FBXO24 Gene

Additional Disease Information for FBXO24

No disorders were found for FBXO24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO24 Gene

Publications for FBXO24 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for FBXO24 Gene

Sources for FBXO24 Gene

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