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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO24 Gene

protein-coding   GIFtS: 46
GCID: GC07P100181

F-Box Protein 24

(Previous name: F-box only protein 24)
  Search for FBXO24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 241 2
FBX242 3 5
F-Box Only Protein 241 2
F-Box Protein Fbx242

External Ids:    HGNC: 135951   Entrez Gene: 262612   Ensembl: ENSG000001063367   OMIM: 6090975   UniProtKB: O754263   

Export aliases for FBXO24 gene to outside databases

Previous GC identifers: GC07P098718 GC07P099781 GC07P099795 GC07P099828 GC07P100021 GC07P094815


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO24 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2009)

GeneCards Summary for FBXO24 Gene: 
FBXO24 (F-box protein 24) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBX24_HUMAN, O75426
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)

Gene Wiki entry for FBXO24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO24 gene promoter:
         PPAR-gamma1   FAC1   Pax-3   STAT1   oct-B3   STAT1beta   PPAR-gamma2   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO24 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

FBXO24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO24 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100181:  view genomic region     (about GC identifiers)

Start:
100,181,605 bp from pter      End:
100,198,740 bp from pter
Size:
17,136 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,543,589-99,558,373     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX24_HUMAN, O75426 (See protein sequence)
Recommended Name: F-box only protein 24  
Size: 580 amino acids; 64889 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: A4D2D4 B4DX91 B4DY42 Q9H0G1
Alternative splicing: 4 isoforms:  O75426-1   O75426-2   O75426-3   O75426-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO24: NX_O75426

Explore proteomics data for FBXO24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75426

  • FBXO24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO24 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001156971.1  NP_036304.2  NP_277041.1  

    ENSEMBL proteins: 
     ENSP00000419587   ENSP00000241071   ENSP00000418814   ENSP00000419602   ENSP00000417179  
     ENSP00000420239   ENSP00000416558   ENSP00000353821  

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    Cloud-Clone Corp. Proteins for FBXO24 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035

    FBXO24 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    3 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR001810 F-box_dom_cyclin-like
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry O75426

    ProtoNet protein and cluster: O75426

    UniProtKB/Swiss-Prot: FBX24_HUMAN, O75426
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 RCC1 repeat


    FBXO24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX24_HUMAN, O75426
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding ----
         
    FBXO24 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO24:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/7 Interacting proteins for FBXO24 (O754263 ENSP000002410714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13I2D: score=1 
    BMPR1BO002383I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    DVL1O146403I2D: score=1 
    SMAD1Q157973I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035

    FBXO24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO24 (FBX24)

    Search CenterWatch for drugs/clinical trials and news about FBXO24 / FBX24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO24 gene (3 alternative transcripts): 
    NM_001163499.1  NM_012172.4  NM_033506.2  

    Unigene Cluster for FBXO24:

    F-box protein 24
    Hs.283764  [show with all ESTs]
    Unigene Representative Sequence: NM_033506
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461079 ENST00000498195 ENST00000241071(uc003uvm.1 uc003uvn.1)
    ENST00000488079 ENST00000474649(uc010lha.1) ENST00000465843 ENST00000466053
    ENST00000468962 ENST00000427939(uc011kka.1 uc011kjz.1) ENST00000360609(uc003uvl.1)

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO24:
    hsa-miR-92a-1* hsa-miR-296-5p hsa-miR-216b hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidFBXO24 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF174604.1 AK292240.1 AK301864.1 AK302252.1 AL136811.1 BC032497.1 BC051745.1 BC067293.1 

    5 DOTS entries:

    DT.405247  DT.91754793  DT.95296990  DT.95262422  DT.121039646 

    22 AceView cDNA sequences:

    BC032497 BC067293 BU656915 BU656991 AL136811 NM_012172 AF174604 BC051745 
    AL042873 NM_033506 BX280566 BI460592 AA250999 BI520326 BX372003 BI559812 
    BI838779 AA811862 CD243717 AA251566 CD358142 BE246760 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO24    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:              -                                                                           
    SP2:              -                 -                             -                           
    SP3:                                                                                          


    ECgene alternative splicing isoforms for FBXO24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGAGAT
    FBXO24 Expression
    About this image


    See FBXO24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO24

    SOURCE GeneReport for Unigene cluster: Hs.283764
        SABiosciences Custom PCR Arrays for FBXO24
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO24 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo241 , 5 F-box protein 241, 5 87.43(n)1
    90.84(a)1
      5 (76.59 cM)5
    711761  NM_027708.11  NP_081984.11 
     1376125035 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO246
    Uncharacterized protein
    65(a)
    1 ↔ 1
    GL344751.1(17609-20101)


    ENSEMBL Gene Tree for FBXO24 (if available)
    TreeFam Gene Tree for FBXO24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    8 SNPs in FBXO24 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0490424
    ----see VAR_0490422 R H mis40--------
    rs43527651,2
    C,H--100186066(+) TCCATC/TTCAGG 3 -- int1 us2k17Minor allele frequency- T:0.00NS EA NA 602
    rs731562121,2
    C,F--100186088(+) AGCCAT/AGGCTA 3 -- int1 us2k13Minor allele frequency- A:0.06NA WA 240
    rs613184571,2
    C,F--100186111(+) AAGGGA/TATTTG 3 -- int1 us2k14Minor allele frequency- T:0.11WA CSA NA 242
    rs585092061,2
    C,F--100186204(+) TGAGCC/GCCTGC 3 -- int1 us2k14Minor allele frequency- G:0.11WA CSA NA 242
    rs798030511,2
    C,F--100186424(+) ACTGTC/TCCTCA 3 -- int1 us2k12Minor allele frequency- T:0.07NA EA 240
    rs1850858471,2
    --100186431(+) CTCAGA/GAAAGC 3 -- int1 us2k10--------
    rs610142021,2
    C,F--100186491(+) TCGCCC/TGGGCT 3 -- int1 us2k12Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for FBXO24 (100181605 - 100198740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXO24:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2659884CNV Deletion23128226
    dgv7399n71CNV Loss21882294
    dgv7398n71CNV Loss21882294
    dgv7400n71CNV Loss21882294
    nsv831072CNV Loss17160897
    nsv5868CNV Loss18451855
    nsv888779CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXO24 for disorders           About MalaCards
    OMIM gene information: 609097    OMIM disorders: --


    FBXO24 for disorders           About GeneDecksing


    Export disorders for FBXO24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO24 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FBXO24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T....Harper J.W. (1999)
    7. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26261 HGNC: 13595 AceView: FBXO24 Ensembl:ENSG00000106336 euGenes: HUgn26261
    ECgene: FBXO24 H-InvDB: FBXO24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO24 gene:
    Search GeneIP for patents involving FBXO24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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