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Aliases for FBXO24 Gene

Aliases for FBXO24 Gene

  • F-Box Protein 24 2 3
  • FBX24 3 4 6
  • F-Box Only Protein 24 2 3
  • F-Box Protein Fbx24 3

External Ids for FBXO24 Gene

Summaries for FBXO24 Gene

Entrez Gene Summary for FBXO24 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for FBXO24 Gene

FBXO24 (F-Box Protein 24) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO24 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Wiki entry for FBXO24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO24 Gene

Genomics for FBXO24 Gene

Genomic Location for FBXO24 Gene

Start:
100,583,982 bp from pter
End:
100,601,117 bp from pter
Size:
17,136 bases
Orientation:
Plus strand

Genomic View for FBXO24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO24 Gene

Regulatory Elements for FBXO24 Gene

Proteins for FBXO24 Gene

  • Protein details for FBXO24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75426-FBX24_HUMAN
    Recommended name:
    F-box only protein 24
    Protein Accession:
    O75426
    Secondary Accessions:
    • A4D2D4
    • B4DX91
    • B4DY42
    • Q9H0G1

    Protein attributes for FBXO24 Gene

    Size:
    580 amino acids
    Molecular mass:
    64889 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO24 Gene

Proteomics data for FBXO24 Gene at MOPED

Post-translational modifications for FBXO24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO24 Gene

Domains for FBXO24 Gene

Gene Families for FBXO24 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO24 Gene

UniProtKB/Swiss-Prot:

FBX24_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • O75426
Similarity:
  • Contains 1 RCC1 repeat.:
    • O75426
genes like me logo Genes that share domains with FBXO24: view

Function for FBXO24 Gene

Molecular function for FBXO24 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with FBXO24: view

Phenotypes for FBXO24 Gene

GenomeRNAi human phenotypes for FBXO24:
genes like me logo Genes that share phenotypes with FBXO24: view

miRNA for FBXO24 Gene

miRTarBase miRNAs that target FBXO24

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO24 Gene

Localization for FBXO24 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO24 Gene COMPARTMENTS Subcellular localization image for FBXO24 gene
Compartment Confidence
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view

Pathways for FBXO24 Gene

SuperPathways for FBXO24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view

No data available for Pathways by source for FBXO24 Gene

Transcripts for FBXO24 Gene

Unigene Clusters for FBXO24 Gene

F-box protein 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - - -
SP3:

Relevant External Links for FBXO24 Gene

GeneLoc Exon Structure for
FBXO24
ECgene alternative splicing isoforms for
FBXO24

Expression for FBXO24 Gene

mRNA expression in normal human tissues for FBXO24 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO24 Gene

This gene is overexpressed in Testis (34.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO24 Gene

SOURCE GeneReport for Unigene cluster for FBXO24 Gene Hs.283764

genes like me logo Genes that share expressions with FBXO24: view

Orthologs for FBXO24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO24 36
  • 99.55 (n)
  • 98.98 (a)
FBXO24 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO24 36
  • 89.35 (n)
  • 90.8 (a)
FBXO24 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO24 36
  • 89.95 (n)
  • 91.71 (a)
FBXO24 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo24 36
  • 87.68 (n)
  • 91.12 (a)
Fbxo24 16
Fbxo24 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO24 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo24 36
  • 86.75 (n)
  • 90.1 (a)
lizard
(Anolis carolinensis)
Reptilia FBXO24 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo24 36
  • 60.1 (n)
  • 50.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToOne
Species with no ortholog for FBXO24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO24 Gene

ENSEMBL:
Gene Tree for FBXO24 (if available)
TreeFam:
Gene Tree for FBXO24 (if available)

Paralogs for FBXO24 Gene

No data available for Paralogs for FBXO24 Gene

Variants for FBXO24 Gene

Sequence variations from dbSNP and Humsavar for FBXO24 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4352765 -- 100,588,443(+) TCCAT(C/T)TCAGG upstream-variant-2KB, intron-variant
rs58509206 -- 100,588,581(+) TGAGC(C/G)CCTGC upstream-variant-2KB, intron-variant
rs61014202 -- 100,588,868(+) TCGCC(C/T)GGGCT upstream-variant-2KB, intron-variant
rs61318457 -- 100,588,488(+) AAGGG(A/T)ATTTG upstream-variant-2KB, intron-variant
rs73156212 -- 100,588,465(+) AGCCA(A/T)GGCTA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO24 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
dgv7400n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv5868 CNV Loss 18451855
esv2659884 CNV Deletion 23128226

Relevant External Links for FBXO24 Gene

HapMap Linkage Disequilibrium report
FBXO24

Disorders for FBXO24 Gene

No disorders were found for FBXO24 Gene.

No data available for UniProtKB/Swiss-Prot for FBXO24 Gene

Publications for FBXO24 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for FBXO24 Gene

Sources for FBXO24 Gene

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