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Aliases for FBXO24 Gene

Aliases for FBXO24 Gene

  • F-Box Protein 24 2 3 5
  • FBX24 3 4
  • F-Box Only Protein 24 2
  • F-Box Protein Fbx24 3

External Ids for FBXO24 Gene

Previous GeneCards Identifiers for FBXO24 Gene

  • GC07P098718
  • GC07P099781
  • GC07P099795
  • GC07P099828
  • GC07P100021
  • GC07P100181
  • GC07P094815

Summaries for FBXO24 Gene

Entrez Gene Summary for FBXO24 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for FBXO24 Gene

FBXO24 (F-Box Protein 24) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO24 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Wiki entry for FBXO24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO24 Gene

Genomics for FBXO24 Gene

Regulatory Elements for FBXO24 Gene

Enhancers for FBXO24 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO24 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO24 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO24 Gene

100,583,982 bp from pter
100,601,117 bp from pter
17,136 bases
Plus strand

Genomic View for FBXO24 Gene

Genes around FBXO24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO24 Gene

Proteins for FBXO24 Gene

  • Protein details for FBXO24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 24
    Protein Accession:
    Secondary Accessions:
    • A4D2D4
    • B4DX91
    • B4DY42
    • Q9H0G1

    Protein attributes for FBXO24 Gene

    580 amino acids
    Molecular mass:
    64889 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO24 Gene


neXtProt entry for FBXO24 Gene

Proteomics data for FBXO24 Gene at MOPED

Post-translational modifications for FBXO24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO24 Gene

Domains & Families for FBXO24 Gene

Gene Families for FBXO24 Gene

Protein Domains for FBXO24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 RCC1 repeat.
  • Contains 1 F-box domain.
  • Contains 1 RCC1 repeat.
genes like me logo Genes that share domains with FBXO24: view

Function for FBXO24 Gene

Molecular function for FBXO24 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view
genes like me logo Genes that share phenotypes with FBXO24: view

Animal Model Products

miRNA for FBXO24 Gene

miRTarBase miRNAs that target FBXO24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO24 Gene

Localization for FBXO24 Gene

Subcellular locations from

Jensen Localization Image for FBXO24 Gene COMPARTMENTS Subcellular localization image for FBXO24 gene
Compartment Confidence
cytosol 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO24 Gene

Pathways & Interactions for FBXO24 Gene

SuperPathways for FBXO24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO24 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO24 Gene

Drugs & Compounds for FBXO24 Gene

No Compound Related Data Available

Transcripts for FBXO24 Gene

Unigene Clusters for FBXO24 Gene

F-box protein 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - - -

Relevant External Links for FBXO24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO24 Gene

mRNA expression in normal human tissues for FBXO24 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO24 Gene

This gene is overexpressed in Testis (x34.9).

Protein differential expression in normal tissues from HIPED for FBXO24 Gene

This gene is overexpressed in Pancreatic juice (60.3) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO24 Gene

SOURCE GeneReport for Unigene cluster for FBXO24 Gene Hs.283764

genes like me logo Genes that share expression patterns with FBXO24: view

Protein tissue co-expression partners for FBXO24 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FBXO24 Gene

Orthologs for FBXO24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO24 35
  • 89.35 (n)
  • 90.8 (a)
FBXO24 36
  • 89 (a)
(Canis familiaris)
Mammalia FBXO24 35
  • 89.95 (n)
  • 91.71 (a)
FBXO24 36
  • 90 (a)
(Mus musculus)
Mammalia Fbxo24 35
  • 87.68 (n)
  • 91.12 (a)
Fbxo24 16
Fbxo24 36
  • 86 (a)
(Pan troglodytes)
Mammalia FBXO24 35
  • 99.55 (n)
  • 98.98 (a)
FBXO24 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fbxo24 35
  • 86.75 (n)
  • 90.1 (a)
(Monodelphis domestica)
Mammalia FBXO24 36
  • 86 (a)
(Anolis carolinensis)
Reptilia FBXO24 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo24 35
  • 60.1 (n)
  • 50.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for FBXO24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO24 Gene

Gene Tree for FBXO24 (if available)
Gene Tree for FBXO24 (if available)

Paralogs for FBXO24 Gene

No data available for Paralogs for FBXO24 Gene

Variants for FBXO24 Gene

Sequence variations from dbSNP and Humsavar for FBXO24 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_049042 -
rs4352765 -- 100,588,443(-) TCCAT(A/C/G/T)TCAGG intron-variant, upstream-variant-2KB
rs79803051 -- 100,588,801(+) ACTGT(C/T)CCTCA intron-variant, upstream-variant-2KB
rs58509206 -- 100,588,581(+) TGAGC(C/G)CCTGC intron-variant, upstream-variant-2KB
rs61014202 -- 100,588,868(+) TCGCC(C/T)GGGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXO24 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
dgv7400n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv5868 CNV Loss 18451855
esv2659884 CNV Deletion 23128226

Variation tolerance for FBXO24 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO24 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO24 Gene

Disorders for FBXO24 Gene

Relevant External Links for FBXO24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO24 Gene

Publications for FBXO24 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation. (PMID: 25582197) Chen W. … Mallampalli R.K. (Mol. Cell. Biol. 2015) 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for FBXO24 Gene

Sources for FBXO24 Gene