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Aliases for FBXO24 Gene

Aliases for FBXO24 Gene

  • F-Box Protein 24 2 3 5
  • F-Box Only Protein 24 2 3
  • FBX24 3 4
  • F-Box Protein Fbx24 3

External Ids for FBXO24 Gene

Previous GeneCards Identifiers for FBXO24 Gene

  • GC07P098718
  • GC07P099781
  • GC07P099795
  • GC07P099828
  • GC07P100021
  • GC07P100181
  • GC07P094815

Summaries for FBXO24 Gene

Entrez Gene Summary for FBXO24 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for FBXO24 Gene

FBXO24 (F-Box Protein 24) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO24 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Wiki entry for FBXO24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO24 Gene

Genomics for FBXO24 Gene

Regulatory Elements for FBXO24 Gene

Enhancers for FBXO24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F100538 1.8 FANTOM5 Ensembl ENCODE 12.9 -39.4 -39369 12.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 SAP25 PILRA IRS3P FBXO24 LRCH4 NYAP1 TSC22D4 C7orf61 PCOLCE PCOLCE-AS1
GH07F100514 1.1 Ensembl ENCODE 21 -68.2 -68154 2.3 TBL1XR1 SIN3A ZEB1 ZNF121 CBX5 SCRT2 FOS ZNF202 ZNF263 ZNF680 ZSCAN25 GIGYF1 STAG3L5P AP4M1 ENSG00000242798 ZNF655 PPP1R35 PCOLCE-AS1 FBXO24 PCOLCE
GH07F100438 1.7 FANTOM5 Ensembl ENCODE 11.5 -141.2 -141160 8.0 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B DMAP1 YY1 SLC30A9 FOS PILRA ZNF789 C7orf61 TSC22D4 NYAP1 ENSG00000242798 IRS3P SAP25 LRCH4 FBXO24
GH07F100835 1.7 FANTOM5 Ensembl ENCODE 10.7 +252.9 252854 2.5 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 CBX5 EPHB4 MIR6875 RN7SL750P RN7SL416P GIGYF1 STAG3L5P NYAP1 ENSG00000242798 MBLAC1 SAP25
GH07F101116 1.6 FANTOM5 ENCODE 9.7 +539.8 539762 15.1 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF416 ZNF207 ENSG00000242798 GIGYF1 STAG3L5P PPP1R35 PCOLCE-AS1 MBLAC1 MEPCE PCOLCE ACTL6B SERPINE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO24 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001050173 1618 4001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for FBXO24 Gene

Chromosome:
7
Start:
100,583,982 bp from pter
End:
100,601,117 bp from pter
Size:
17,136 bases
Orientation:
Plus strand

Genomic View for FBXO24 Gene

Genes around FBXO24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO24 Gene

Proteins for FBXO24 Gene

  • Protein details for FBXO24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75426-FBX24_HUMAN
    Recommended name:
    F-box only protein 24
    Protein Accession:
    O75426
    Secondary Accessions:
    • A4D2D4
    • B4DX91
    • B4DY42
    • Q9H0G1

    Protein attributes for FBXO24 Gene

    Size:
    580 amino acids
    Molecular mass:
    64889 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO24 Gene

Post-translational modifications for FBXO24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO24 Gene

Domains & Families for FBXO24 Gene

Gene Families for FBXO24 Gene

Protein Domains for FBXO24 Gene

Graphical View of Domain Structure for InterPro Entry

O75426

UniProtKB/Swiss-Prot:

FBX24_HUMAN :
  • Contains 1 F-box domain.
  • Contains 1 RCC1 repeat.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 1 RCC1 repeat.
genes like me logo Genes that share domains with FBXO24: view

Function for FBXO24 Gene

Molecular function for FBXO24 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with FBXO24: view
genes like me logo Genes that share phenotypes with FBXO24: view

Animal Model Products

miRNA for FBXO24 Gene

miRTarBase miRNAs that target FBXO24

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO24 Gene

Localization for FBXO24 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO24 gene
Compartment Confidence
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO24 Gene

Pathways & Interactions for FBXO24 Gene

SuperPathways for FBXO24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
genes like me logo Genes that share ontologies with FBXO24: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO24 Gene

Transcripts for FBXO24 Gene

Unigene Clusters for FBXO24 Gene

F-box protein 24:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: - - -
SP3:

Relevant External Links for FBXO24 Gene

GeneLoc Exon Structure for
FBXO24
ECgene alternative splicing isoforms for
FBXO24

Expression for FBXO24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO24 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO24 Gene

This gene is overexpressed in Testis (x34.9).

Protein differential expression in normal tissues from HIPED for FBXO24 Gene

This gene is overexpressed in Pancreatic juice (60.3) and Testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO24 Gene



Protein tissue co-expression partners for FBXO24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO24 Gene:

FBXO24

SOURCE GeneReport for Unigene cluster for FBXO24 Gene:

Hs.283764
genes like me logo Genes that share expression patterns with FBXO24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FBXO24 Gene

Orthologs for FBXO24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO24 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia FBXO24 34 35
  • 89.95 (n)
cow
(Bos Taurus)
Mammalia FBXO24 34 35
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Fbxo24 34 16 35
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo24 34
  • 86.75 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO24 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO24 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo24 34
  • 60.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for FBXO24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO24 Gene

ENSEMBL:
Gene Tree for FBXO24 (if available)
TreeFam:
Gene Tree for FBXO24 (if available)

Paralogs for FBXO24 Gene

No data available for Paralogs for FBXO24 Gene

Variants for FBXO24 Gene

Sequence variations from dbSNP and Humsavar for FBXO24 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111359243 -- 100,585,541(+) GCTTC(A/G)TAGAC intron-variant, upstream-variant-2KB
rs111434481 -- 100,580,893(+) ACACA(A/C)ACATG intron-variant, upstream-variant-2KB
rs111523972 -- 100,584,005(+) CTCCC(C/T)GCCAC intron-variant, utr-variant-5-prime
rs111713467 -- 100,580,570(+) AACAC(-/A)ATACA intron-variant, upstream-variant-2KB
rs112129080 -- 100,586,206(+) GCGGT(C/G)TCCGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXO24 Gene

Variant ID Type Subtype PubMed ID
nsv951386 CNV deletion 24416366
nsv831072 CNV loss 17160897
nsv5868 CNV deletion 18451855
nsv476435 CNV novel sequence insertion 20440878
esv3614300 CNV loss 21293372
esv2734888 CNV deletion 23290073
esv2659884 CNV deletion 23128226

Variation tolerance for FBXO24 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO24 Gene

Human Gene Mutation Database (HGMD)
FBXO24
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO24 Gene

Disorders for FBXO24 Gene

Relevant External Links for FBXO24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO24

No disorders were found for FBXO24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO24 Gene

Publications for FBXO24 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for FBXO24 Gene

Sources for FBXO24 Gene

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