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FBXO24 Gene

protein-coding   GIFtS: 47
GCID: GC07P100181

F-Box Protein 24

(Previous name: F-box only protein 24)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 241 2
FBX242 3 5
F-Box Only Protein 241 2
F-Box Protein Fbx242

External Ids:    HGNC: 135951   Entrez Gene: 262612   Ensembl: ENSG000001063367   OMIM: 6090975   UniProtKB: O754263   

Export aliases for FBXO24 gene to outside databases

Previous GC identifers: GC07P098718 GC07P099781 GC07P099795 GC07P099828 GC07P100021 GC07P094815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO24 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2009)

GeneCards Summary for FBXO24 Gene:
FBXO24 (F-box protein 24) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBX24_HUMAN, O75426
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)

Gene Wiki entry for FBXO24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO24 gene promoter:
         PPAR-gamma1   FAC1   Pax-3   STAT1   oct-B3   STAT1beta   PPAR-gamma2   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO24 promoter sequence
   Search Chromatin IP Primers for FBXO24

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

FBXO24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO24 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100181:  view genomic region     (about GC identifiers)

Start:
100,181,605 bp from pter      End:
100,198,740 bp from pter
Size:
17,136 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,543,589-99,558,373     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBX24_HUMAN, O75426 (See protein sequence)
Recommended Name: F-box only protein 24  
Size: 580 amino acids; 64889 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: A4D2D4 B4DX91 B4DY42 Q9H0G1
Alternative splicing: 4 isoforms:  O75426-1   O75426-2   O75426-3   O75426-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO24: NX_O75426

Explore proteomics data for FBXO24 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO24 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001156971.1  NP_036304.2  NP_277041.1  

    ENSEMBL proteins: 
     ENSP00000419587   ENSP00000241071   ENSP00000418814   ENSP00000419602   ENSP00000417179  
     ENSP00000420239   ENSP00000416558   ENSP00000353821  

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    Cloud-Clone Corp. Proteins for FBXO24

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    3 InterPro protein domains:
     IPR009091 RCC1/BLIP-II
     IPR001810 F-box_dom
     IPR000408 Reg_chr_condens

    Graphical View of Domain Structure for InterPro Entry O75426

    ProtoNet protein and cluster: O75426

    UniProtKB/Swiss-Prot: FBX24_HUMAN, O75426
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 RCC1 repeat


    Find genes that share domains with FBXO24           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX24_HUMAN, O75426
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXO24           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO24:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    hsa-mir-26b-5p (MIRT028996)

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    hsa-miR-92a-1* hsa-miR-296-5p hsa-miR-216b hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidFBXO24 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035

    Find genes that share ontologies with FBXO24           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO24
    Interactions:

        Search GeneGlobe Interaction Network for FBXO24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for FBXO24 (O754263 ENSP000002410714) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN2Q9Y2T13I2D: score=1 
    BMPR1BO002383I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    DVL1O146403I2D: score=1 
    SMAD1Q157973I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035

    Find genes that share ontologies with FBXO24           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO24 (FBX24)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO24 gene (3 alternative transcripts): 
    NM_001163499.1  NM_012172.4  NM_033506.2  

    Unigene Cluster for FBXO24:

    F-box protein 24
    Hs.283764  [show with all ESTs]
    Unigene Representative Sequence: NM_033506
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461079 ENST00000498195 ENST00000241071(uc003uvm.1 uc003uvn.1)
    ENST00000488079 ENST00000474649(uc010lha.1) ENST00000465843 ENST00000466053
    ENST00000468962 ENST00000427939(uc011kka.1 uc011kjz.1) ENST00000360609(uc003uvl.1)

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate FBXO24:
    hsa-miR-92a-1* hsa-miR-296-5p hsa-miR-216b hsa-miR-3943
    SwitchGear 3'UTR luciferase reporter plasmidFBXO24 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXO24
      QuantiFast Probe-based Assays in human, mouse, rat FBXO24

    Additional mRNA sequence: 

    AF174604.1 AK292240.1 AK301864.1 AK302252.1 AL136811.1 BC032497.1 BC051745.1 BC067293.1 

    5 DOTS entries:

    DT.405247  DT.91754793  DT.95296990  DT.95262422  DT.121039646 

    22 AceView cDNA sequences:

    AL136811 AF174604 BC051745 BX280566 BC067293 NM_012172 BC032497 BU656915 
    AL042873 BU656991 NM_033506 BI520326 AA250999 BX372003 BI460592 BI838779 
    CD358142 BI559812 AA811862 CD243717 AA251566 BE246760 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO24    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:              -                                                                           
    SP2:              -                 -                             -                           
    SP3:                                                                                          


    ECgene alternative splicing isoforms for FBXO24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGAGAT
    FBXO24 Expression
    About this image

    FBXO24 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO24 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283764
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO24 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo241 , 5 F-box protein 241, 5 87.68(n)1
    91.12(a)1
      5 (76.59 cM)5
    711761  NM_027708.11  NP_081984.11 
     1376125035 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO246
    F-box protein 24
    67(a)
    1 ↔ 1
    GL344751.1(17609-20101)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo241 F-box protein 24 60.1(n)
    50.93(a)
      100158645  NM_001128050.1  NP_001121522.1 


    ENSEMBL Gene Tree for FBXO24 (if available)
    TreeFam Gene Tree for FBXO24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for FBXO24    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs43527651,2
    C,H--100186066(+) TCCATC/TTCAGG 3 -- int1 us2k17Minor allele frequency- T:0.00NS EA NA 602
    rs731562121,2
    C,F--100186088(+) AGCCAT/AGGCTA 3 -- int1 us2k13Minor allele frequency- A:0.06NA WA 240
    rs613184571,2
    C,F--100186111(+) AAGGGA/TATTTG 3 -- int1 us2k14Minor allele frequency- T:0.11WA CSA NA 242
    rs585092061,2
    C,F--100186204(+) TGAGCC/GCCTGC 3 -- int1 us2k14Minor allele frequency- G:0.11WA CSA NA 242
    rs798030511,2
    C,F--100186424(+) ACTGTC/TCCTCA 3 -- int1 us2k12Minor allele frequency- T:0.07NA EA 240
    rs1850858471,2
    --100186431(+) CTCAGA/GAAAGC 3 -- int1 us2k10--------
    rs610142021,2
    C,F--100186491(+) TCGCCC/TGGGCT 3 -- int1 us2k12Minor allele frequency- T:0.04WA 120
    rs78014921,2,4
    ----see VAR_0490422 mis40--------

    HapMap Linkage Disequilibrium report for FBXO24 (100181605 - 100198740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXO24:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    esv2659884CNV Deletion23128226
    dgv7399n71CNV Loss21882294
    dgv7398n71CNV Loss21882294
    dgv7400n71CNV Loss21882294
    nsv831072CNV Loss17160897
    nsv5868CNV Loss18451855
    nsv888779CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609097    OMIM disorders: --


    Find genes that share disorders with FBXO24           About GenesLikeMe


    Export disorders for FBXO24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO24 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FBXO24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26261 HGNC: 13595 AceView: FBXO24 Ensembl:ENSG00000106336 euGenes: HUgn26261
    ECgene: FBXO24 H-InvDB: FBXO24

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO24 gene:
    Search GeneIP for patents involving FBXO24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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