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Aliases for FBXO22 Gene

Aliases for FBXO22 Gene

  • F-Box Protein 22 2 3 5
  • FIST Domain Containing 1 2 3
  • F-Box Protein FBX22p44 3 4
  • F-Box Only Protein 22 2 3
  • FBX22 3 4
  • FISTC1 3

External Ids for FBXO22 Gene

Previous GeneCards Identifiers for FBXO22 Gene

  • GC15P072072
  • GC15P069285
  • GC15P073772
  • GC15P073912
  • GC15P073983
  • GC15P076196

Summaries for FBXO22 Gene

Entrez Gene Summary for FBXO22 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for FBXO22 Gene

FBXO22 (F-Box Protein 22) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO22 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Additional gene information for FBXO22 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO22 Gene

Genomics for FBXO22 Gene

Regulatory Elements for FBXO22 Gene

Enhancers for FBXO22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H075901 1.2 ENCODE 47.6 -0.8 -807 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SIN3A FBXO22 ENSG00000260274 MAN2C1 DNM1P35 NRG4 DNM1P49 LOC105370902 ENSG00000261232 GOLGA6D
GH15H074936 1.1 ENCODE 46.6 -966.2 -966189 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SIN3A ENSG00000260274 MAN2C1 EDC3 FBXO22 ENSG00000203392 RPP25 DNM1P35 LOC441728 CLK3
GH15H075366 1.2 ENCODE 34 -535.1 -535105 3.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SIN3A DNM1P35 EDC3 MAN2C1 LOC441728 SNUPN FBXO22 COMMD4 ENSG00000260274 ENSG00000203392
GH15H075449 1.8 FANTOM5 ENCODE dbSUPER 18.6 -450.5 -450503 8.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MAN2C1 ENSG00000260274 SIN3A SNUPN DNM1P34 EDC3 FBXO22 LOC105370902 COMMD4 GOLGA6D
GH15H075346 1.3 Ensembl ENCODE 25.4 -554.7 -554746 5 HDGF ARID4B SIN3A ZNF2 ZNF143 SP3 SP5 MXD4 ZC3H11A REST SIN3A MAN2C1 ENSG00000260274 DNM1P35 EDC3 SNUPN FBXO22 LOC441728 PTPN9 SNX33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO22 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079474 341 1601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for FBXO22 Gene

Genomic Locations for FBXO22 Gene
chr15:75,903,859-75,942,510
(GRCh38/hg38)
Size:
38,652 bases
Orientation:
Plus strand
chr15:76,196,200-76,227,609
(GRCh37/hg19)

Genomic View for FBXO22 Gene

Genes around FBXO22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO22 Gene

Proteins for FBXO22 Gene

  • Protein details for FBXO22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEZ5-FBX22_HUMAN
    Recommended name:
    F-box only protein 22
    Protein Accession:
    Q8NEZ5
    Secondary Accessions:
    • Q0D2P8
    • Q6PIL5
    • Q8IXW3
    • Q9H824
    • Q9UKC0

    Protein attributes for FBXO22 Gene

    Size:
    403 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH39024.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO22 Gene

Post-translational modifications for FBXO22 Gene

  • Ubiquitination at posLast=4040
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO22 Gene

Domains & Families for FBXO22 Gene

Gene Families for FBXO22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO22: view

No data available for UniProtKB/Swiss-Prot for FBXO22 Gene

Function for FBXO22 Gene

Molecular function for FBXO22 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Phenotypes From GWAS Catalog for FBXO22 Gene

Gene Ontology (GO) - Molecular Function for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS,EXP --
GO:0005515 protein binding IPI 26496610
GO:0005549 odorant binding IEA --
genes like me logo Genes that share ontologies with FBXO22: view
genes like me logo Genes that share phenotypes with FBXO22: view

Animal Models for FBXO22 Gene

MGI Knock Outs for FBXO22:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO22 Gene

Localization for FBXO22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO22 Gene

Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO22 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FBXO22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FBXO22 Gene

Pathways & Interactions for FBXO22 Gene

genes like me logo Genes that share pathways with FBXO22: view

Gene Ontology (GO) - Biological Process for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006464 cellular protein modification process TAS 10531035
GO:0006511 ubiquitin-dependent protein catabolic process TAS 10531035
GO:0006913 nucleocytoplasmic transport IEA --
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with FBXO22: view

No data available for SIGNOR curated interactions for FBXO22 Gene

Drugs & Compounds for FBXO22 Gene

No Compound Related Data Available

Transcripts for FBXO22 Gene

Unigene Clusters for FBXO22 Gene

F-box protein 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for FBXO22 Gene

GeneLoc Exon Structure for
FBXO22
ECgene alternative splicing isoforms for
FBXO22

Expression for FBXO22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO22 Gene

Protein differential expression in normal tissues from HIPED for FBXO22 Gene

This gene is overexpressed in Breast (11.4), Stomach (9.7), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO22 Gene



Protein tissue co-expression partners for FBXO22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO22 Gene:

FBXO22

SOURCE GeneReport for Unigene cluster for FBXO22 Gene:

Hs.591115

mRNA Expression by UniProt/SwissProt for FBXO22 Gene:

Q8NEZ5-FBX22_HUMAN
Tissue specificity: Predominantly expressed in liver, also enriched in cardiac muscle.

Evidence on tissue expression from TISSUES for FBXO22 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with FBXO22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO22 Gene

Orthologs for FBXO22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO22 33 34
  • 99.75 (n)
cow
(Bos Taurus)
Mammalia FBXO22 33 34
  • 90.38 (n)
dog
(Canis familiaris)
Mammalia FBXO22 33 34
  • 89.44 (n)
mouse
(Mus musculus)
Mammalia Fbxo22 33 16 34
  • 88.39 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo22 33
  • 87.64 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO22 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO22 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO22 33 34
  • 70.5 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO22 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo22 33
  • 59.85 (n)
Str.10458 33
zebrafish
(Danio rerio)
Actinopterygii fbxo22 33 34
  • 54.33 (n)
-- 33
Species where no ortholog for FBXO22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO22 Gene

ENSEMBL:
Gene Tree for FBXO22 (if available)
TreeFam:
Gene Tree for FBXO22 (if available)

Paralogs for FBXO22 Gene

No data available for Paralogs for FBXO22 Gene

Variants for FBXO22 Gene

Sequence variations from dbSNP and Humsavar for FBXO22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000167999 -- 75,916,678(+) TTCCA(A/T)GTCTA intron-variant
rs1000223241 -- 75,924,539(+) GCTTT(A/G)CCCAC intron-variant
rs1000224456 -- 75,907,112(+) CATGA(C/T)TTTTC intron-variant
rs1000277525 -- 75,937,138(+) AAAAC(-/AT)AATTG intron-variant, utr-variant-3-prime
rs1000362232 -- 75,909,473(+) GCAGT(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO22 Gene

Variant ID Type Subtype PubMed ID
nsv1116463 OTHER inversion 24896259
nsv1044733 CNV loss 25217958
esv3636933 CNV gain 21293372
esv2749898 CNV deletion 23290073
esv2749895 CNV deletion 23290073
dgv2622n100 CNV gain 25217958

Variation tolerance for FBXO22 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO22 Gene

Disorders for FBXO22 Gene

Relevant External Links for FBXO22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO22

No disorders were found for FBXO22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO22 Gene

Publications for FBXO22 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 60
  2. FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes. (PMID: 17855421) Borziak K … Zhulin IB (Bioinformatics (Oxford, England) 2007) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 60

Products for FBXO22 Gene

Sources for FBXO22 Gene

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