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Aliases for FBXO22 Gene

Aliases for FBXO22 Gene

  • F-Box Protein 22 2 3
  • FBX22 3 4 6
  • FIST Domain Containing 1 2 3
  • F-Box Protein FBX22p44 3 4
  • F-Box Only Protein 22 2 3
  • FISTC1 3

External Ids for FBXO22 Gene

Previous GeneCards Identifiers for FBXO22 Gene

  • GC15P072072
  • GC15P069285
  • GC15P073772
  • GC15P073912
  • GC15P073983
  • GC15P076196

Summaries for FBXO22 Gene

Entrez Gene Summary for FBXO22 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for FBXO22 Gene

FBXO22 (F-Box Protein 22) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO22 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO22 Gene

Genomics for FBXO22 Gene

Regulatory Elements for FBXO22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXO22 Gene

Start:
75,903,859 bp from pter
End:
75,942,510 bp from pter
Size:
38,652 bases
Orientation:
Plus strand

Genomic View for FBXO22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO22 Gene

Proteins for FBXO22 Gene

  • Protein details for FBXO22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEZ5-FBX22_HUMAN
    Recommended name:
    F-box only protein 22
    Protein Accession:
    Q8NEZ5
    Secondary Accessions:
    • Q0D2P8
    • Q6PIL5
    • Q8IXW3
    • Q9H824
    • Q9UKC0

    Protein attributes for FBXO22 Gene

    Size:
    403 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH39024.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO22 Gene

Proteomics data for FBXO22 Gene at MOPED

Post-translational modifications for FBXO22 Gene

  • Ubiquitination at Lys40
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO22 Gene

Domains for FBXO22 Gene

Gene Families for FBXO22 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NEZ5

UniProtKB/Swiss-Prot:

FBX22_HUMAN :
  • Q8NEZ5
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO22: view

Function for FBXO22 Gene

Molecular function for FBXO22 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

Gene Ontology (GO) - Molecular Function for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531037
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXO22: view

Animal Model Products

CRISPR Products

miRNA for FBXO22 Gene

miRTarBase miRNAs that target FBXO22

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO22 Gene

Localization for FBXO22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO22 Gene

Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO22 Gene COMPARTMENTS Subcellular localization image for FBXO22 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FBXO22: view

Pathways for FBXO22 Gene

SuperPathways for FBXO22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006464 cellular protein modification process TAS 10531035
GO:0006511 ubiquitin-dependent protein catabolic process TAS 10531035
GO:0006913 nucleocytoplasmic transport IEA --
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with FBXO22: view

No data available for Pathways by source for FBXO22 Gene

Transcripts for FBXO22 Gene

Unigene Clusters for FBXO22 Gene

F-box protein 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for FBXO22 Gene

GeneLoc Exon Structure for
FBXO22
ECgene alternative splicing isoforms for
FBXO22

Expression for FBXO22 Gene

mRNA expression in normal human tissues for FBXO22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO22 Gene

SOURCE GeneReport for Unigene cluster for FBXO22 Gene Hs.591115

mRNA Expression by UniProt/SwissProt for FBXO22 Gene

Q8NEZ5-FBX22_HUMAN
Tissue specificity: Predominantly expressed in liver, also enriched in cardiac muscle.
genes like me logo Genes that share expressions with FBXO22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FBXO22 Gene

Orthologs for FBXO22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO22 35
  • 99.75 (n)
  • 99.5 (a)
FBXO22 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO22 35
  • 90.38 (n)
  • 89.95 (a)
FBXO22 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO22 35
  • 89.44 (n)
  • 88.53 (a)
FBXO22 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo22 35
  • 88.39 (n)
  • 92.54 (a)
Fbxo22 16
Fbxo22 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO22 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO22 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo22 35
  • 87.64 (n)
  • 92.98 (a)
chicken
(Gallus gallus)
Aves FBXO22 35
  • 70.5 (n)
  • 68.41 (a)
FBXO22 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO22 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo22 35
  • 59.85 (n)
  • 54.73 (a)
Str.10458 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fbxo22 35
  • 54.33 (n)
  • 51.47 (a)
fbxo22 36
  • 49 (a)
OneToOne
Species with no ortholog for FBXO22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO22 Gene

ENSEMBL:
Gene Tree for FBXO22 (if available)
TreeFam:
Gene Tree for FBXO22 (if available)

Paralogs for FBXO22 Gene

No data available for Paralogs for FBXO22 Gene

Variants for FBXO22 Gene

Sequence variations from dbSNP and Humsavar for FBXO22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs335675 -- 75,927,944(+) CAAAG(C/T)ACCCG intron-variant
rs335676 -- 75,928,171(+) tcagc(C/T)attgt intron-variant
rs335677 -- 75,929,247(+) CCCAC(C/G)TGGAT intron-variant
rs335678 -- 75,929,595(+) GCTTC(A/G)TTATT intron-variant
rs335679 -- 75,929,799(+) TGCAA(G/T)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO22 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv904398 CNV Gain 21882294

Relevant External Links for FBXO22 Gene

HapMap Linkage Disequilibrium report
FBXO22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO22 Gene

Disorders for FBXO22 Gene

No disorders were found for FBXO22 Gene.

No data available for UniProtKB/Swiss-Prot for FBXO22 Gene

Publications for FBXO22 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes. (PMID: 17855421) Borziak K. … Zhulin I.B. (Bioinformatics 2007) 2 3

Products for FBXO22 Gene

Sources for FBXO22 Gene

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