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Aliases for FBXO22 Gene

Aliases for FBXO22 Gene

  • F-Box Protein 22 2 3 5
  • FIST Domain Containing 1 2 3
  • F-Box Protein FBX22p44 3 4
  • FBX22 3 4
  • F-Box Only Protein 22 2
  • FISTC1 3

External Ids for FBXO22 Gene

Previous GeneCards Identifiers for FBXO22 Gene

  • GC15P072072
  • GC15P069285
  • GC15P073772
  • GC15P073912
  • GC15P073983
  • GC15P076196

Summaries for FBXO22 Gene

Entrez Gene Summary for FBXO22 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for FBXO22 Gene

FBXO22 (F-Box Protein 22) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO22 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO22 Gene

Genomics for FBXO22 Gene

Regulatory Elements for FBXO22 Gene

Enhancers for FBXO22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO22 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO22 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO22 Gene

75,903,859 bp from pter
75,942,510 bp from pter
38,652 bases
Plus strand

Genomic View for FBXO22 Gene

Genes around FBXO22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO22 Gene

Proteins for FBXO22 Gene

  • Protein details for FBXO22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 22
    Protein Accession:
    Secondary Accessions:
    • Q0D2P8
    • Q6PIL5
    • Q8IXW3
    • Q9H824
    • Q9UKC0

    Protein attributes for FBXO22 Gene

    403 amino acids
    Molecular mass:
    44508 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=AAH39024.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO22 Gene


neXtProt entry for FBXO22 Gene

Proteomics data for FBXO22 Gene at MOPED

Post-translational modifications for FBXO22 Gene

  • Ubiquitination at Lys 40
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO22 Gene

Domains & Families for FBXO22 Gene

Gene Families for FBXO22 Gene

Protein Domains for FBXO22 Gene


Suggested Antigen Peptide Sequences for FBXO22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO22: view

Function for FBXO22 Gene

Molecular function for FBXO22 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
genes like me logo Genes that share phenotypes with FBXO22: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO22 Gene

Localization for FBXO22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO22 Gene

Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

Jensen Localization Image for FBXO22 Gene COMPARTMENTS Subcellular localization image for FBXO22 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FBXO22 Gene

Pathways & Interactions for FBXO22 Gene

SuperPathways for FBXO22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006464 cellular protein modification process TAS 10531035
GO:0006913 nucleocytoplasmic transport IEA --
GO:0009267 cellular response to starvation IEA --
GO:0010830 regulation of myotube differentiation IEA --
genes like me logo Genes that share ontologies with FBXO22: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO22 Gene

Drugs & Compounds for FBXO22 Gene

No Compound Related Data Available

Transcripts for FBXO22 Gene

Unigene Clusters for FBXO22 Gene

F-box protein 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP3: -

Relevant External Links for FBXO22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO22 Gene

mRNA expression in normal human tissues for FBXO22 Gene

Protein differential expression in normal tissues from HIPED for FBXO22 Gene

This gene is overexpressed in Breast (11.4), Stomach (9.7), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO22 Gene

SOURCE GeneReport for Unigene cluster for FBXO22 Gene Hs.591115

mRNA Expression by UniProt/SwissProt for FBXO22 Gene

Tissue specificity: Predominantly expressed in liver, also enriched in cardiac muscle.
genes like me logo Genes that share expression patterns with FBXO22: view

Protein tissue co-expression partners for FBXO22 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FBXO22 Gene

Orthologs for FBXO22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO22 35
  • 90.38 (n)
  • 89.95 (a)
FBXO22 36
  • 88 (a)
(Canis familiaris)
Mammalia FBXO22 35
  • 89.44 (n)
  • 88.53 (a)
FBXO22 36
  • 88 (a)
(Mus musculus)
Mammalia Fbxo22 35
  • 88.39 (n)
  • 92.54 (a)
Fbxo22 16
Fbxo22 36
  • 93 (a)
(Pan troglodytes)
Mammalia FBXO22 35
  • 99.75 (n)
  • 99.5 (a)
FBXO22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo22 35
  • 87.64 (n)
  • 92.98 (a)
(Monodelphis domestica)
Mammalia FBXO22 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO22 36
  • 67 (a)
(Gallus gallus)
Aves FBXO22 35
  • 70.5 (n)
  • 68.41 (a)
FBXO22 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FBXO22 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo22 35
  • 59.85 (n)
  • 54.73 (a)
Str.10458 35
(Danio rerio)
Actinopterygii -- 35
fbxo22 35
  • 54.33 (n)
  • 51.47 (a)
fbxo22 36
  • 49 (a)
Species with no ortholog for FBXO22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO22 Gene

Gene Tree for FBXO22 (if available)
Gene Tree for FBXO22 (if available)

Paralogs for FBXO22 Gene

No data available for Paralogs for FBXO22 Gene

Variants for FBXO22 Gene

Sequence variations from dbSNP and Humsavar for FBXO22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs335675 -- 75,927,944(+) CAAAG(C/T)ACCCG intron-variant
rs335676 -- 75,928,171(+) tcagc(C/T)attgt intron-variant
rs335677 -- 75,929,247(+) CCCAC(C/G)TGGAT intron-variant
rs335678 -- 75,929,595(+) GCTTC(A/G)TTATT intron-variant
rs335679 -- 75,929,799(+) TGCAA(G/T)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO22 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv904398 CNV Gain 21882294

Variation tolerance for FBXO22 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO22 Gene

Disorders for FBXO22 Gene

Relevant External Links for FBXO22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO22 Gene

Publications for FBXO22 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes. (PMID: 17855421) Borziak K. … Zhulin I.B. (Bioinformatics 2007) 2 3
  3. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for FBXO22 Gene

Sources for FBXO22 Gene