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Aliases for FBXO21 Gene

Aliases for FBXO21 Gene

  • F-Box Protein 21 2 3
  • FBX21 3 4 6
  • F-Box Only Protein 21 2 3
  • KIAA0875 4 6

External Ids for FBXO21 Gene

Summaries for FBXO21 Gene

Entrez Gene Summary for FBXO21 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO21 Gene

FBXO21 (F-Box Protein 21) is a Protein Coding gene. Diseases associated with FBXO21 include mast cell neoplasm. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO21 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO21 Gene

Genomics for FBXO21 Gene

Genomic Location for FBXO21 Gene

Start:
117,141,988 bp from pter
End:
117,190,531 bp from pter
Size:
48,544 bases
Orientation:
Minus strand

Genomic View for FBXO21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO21 Gene

Regulatory Elements for FBXO21 Gene

Proteins for FBXO21 Gene

  • Protein details for FBXO21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94952-FBX21_HUMAN
    Recommended name:
    F-box only protein 21
    Protein Accession:
    O94952
    Secondary Accessions:
    • B3KMF0
    • Q5BJG0
    • Q9H087

    Protein attributes for FBXO21 Gene

    Size:
    628 amino acids
    Molecular mass:
    72270 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO21 Gene

Proteomics data for FBXO21 Gene at MOPED

Post-translational modifications for FBXO21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO21 Gene

No data available for DME Specific Peptides for FBXO21 Gene

Domains for FBXO21 Gene

Gene Families for FBXO21 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO21 Gene

UniProtKB/Swiss-Prot:

FBX21_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • O94952
genes like me logo Genes that share domains with FBXO21: view

Function for FBXO21 Gene

Molecular function for FBXO21 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXO21: view

Phenotypes for FBXO21 Gene

GenomeRNAi human phenotypes for FBXO21:
genes like me logo Genes that share phenotypes with FBXO21: view

miRNA for FBXO21 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO21 Gene

Localization for FBXO21 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO21 Gene COMPARTMENTS Subcellular localization image for FBXO21 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
genes like me logo Genes that share ontologies with FBXO21: view

Pathways for FBXO21 Gene

SuperPathways for FBXO21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0016567 protein ubiquitination NAS 10531035
genes like me logo Genes that share ontologies with FBXO21: view

No data available for Pathways by source for FBXO21 Gene

Transcripts for FBXO21 Gene

Unigene Clusters for FBXO21 Gene

F-box protein 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for FBXO21 Gene

GeneLoc Exon Structure for
FBXO21
ECgene alternative splicing isoforms for
FBXO21

Expression for FBXO21 Gene

mRNA expression in normal human tissues for FBXO21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO21 Gene

SOURCE GeneReport for Unigene cluster for FBXO21 Gene Hs.740376

genes like me logo Genes that share expressions with FBXO21: view

Orthologs for FBXO21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO21 36
  • 99.89 (n)
  • 100 (a)
FBXO21 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO21 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO21 36
  • 92.82 (n)
  • 98.72 (a)
FBXO21 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo21 36
  • 87.67 (n)
  • 95.69 (a)
Fbxo21 16
Fbxo21 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO21 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO21 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo21 36
  • 87.9 (n)
  • 96.13 (a)
chicken
(Gallus gallus)
Aves FBXO21 36
  • 75.88 (n)
  • 79.56 (a)
FBXO21 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO21 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo21 36
  • 63.29 (n)
  • 60.49 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo21 36
  • 63.32 (n)
  • 61.16 (a)
fbxo21 37
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for FBXO21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO21 Gene

ENSEMBL:
Gene Tree for FBXO21 (if available)
TreeFam:
Gene Tree for FBXO21 (if available)

Paralogs for FBXO21 Gene

No data available for Paralogs for FBXO21 Gene

Variants for FBXO21 Gene

Sequence variations from dbSNP and Humsavar for FBXO21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs868757 -- 117,173,794(+) AGAGA(C/T)GGAAG intron-variant
rs875036 -- 117,151,732(-) CCCCT(A/G)CCCTT intron-variant
rs904656 -- 117,174,093(+) GATCG(C/T)GCCAC intron-variant
rs955177 -- 117,152,536(-) TTTTT(C/T)CCCCC intron-variant
rs1060232 -- 117,144,858(-) GGCGT(C/T)TTCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO21 Gene

Variant ID Type Subtype PubMed ID
nsv832526 CNV Loss 17160897
nsv899542 CNV Gain 21882294
esv2746433 CNV Deletion 23290073
nsv510592 CNV Loss 20534489

Relevant External Links for FBXO21 Gene

HapMap Linkage Disequilibrium report
FBXO21

Disorders for FBXO21 Gene

(1) MalaCards Diseases for FBXO21 Gene

Search for FBXO21 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FBXO21 Gene

Relevant External Links for FBXO21

Genetic Association Database (GAD)
FBXO21
Human Genome Epidemiology (HuGE) Navigator
FBXO21
genes like me logo Genes that share disorders with FBXO21: view

No data available for UniProtKB/Swiss-Prot for FBXO21 Gene

Publications for FBXO21 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FBXO21 Gene

Sources for FBXO21 Gene

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