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FBXO21 Gene

protein-coding   GIFtS: 50
GCID: GC12M117581

F-Box Protein 21

(Previous name: F-box only protein 21)
  See FBXO21-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 211 2
FBX212 3 5
F-Box Only Protein 211 2
KIAA08753 5

External Ids:    HGNC: 135921   Entrez Gene: 230142   Ensembl: ENSG000001351087   OMIM: 6090955   UniProtKB: O949523   

Export aliases for FBXO21 gene to outside databases

Previous GC identifers: GC12P116427 GC12M117102 GC12M117364 GC12M115994 GC12M115995 GC12M116044 GC12M114590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO21 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. (provided
by RefSeq, Jul 2008)

GeneCards Summary for FBXO21 Gene:
FBXO21 (F-box protein 21) is a protein-coding gene. Diseases associated with FBXO21 include mast cell neoplasm. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO21 gene promoter:
         GR   Elk-1   Sox5   STAT1   STAT1beta   LUN-1   STAT1alpha   AREB6   ZID   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO21 promoter sequence
   Search Chromatin IP Primers for FBXO21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.22   Ensembl cytogenetic band:  12q24.22   HGNC cytogenetic band: 12q24.23

FBXO21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO21 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M117581:  view genomic region     (about GC identifiers)

Start:
117,581,146 bp from pter      End:
117,628,336 bp from pter
Size:
47,191 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952 (See protein sequence)
Recommended Name: F-box only protein 21  
Size: 628 amino acids; 72270 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Sequence caution: Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp;
Secondary accessions: B3KMF0 Q5BJG0 Q9H087
Alternative splicing: 2 isoforms:  O94952-2   O94952-1   (May be due to a competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO21: NX_O94952

Explore proteomics data for FBXO21 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055817.1  NP_296373.1  

    ENSEMBL proteins: 
     ENSP00000414468   ENSP00000449264   ENSP00000328187   ENSP00000446973  

    FBXO21 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for FBXO21
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    Novus Biologicals FBXO21 Protein
    Novus Biologicals FBXO21 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO21

     
    Search eBioscience for Proteins for FBXO21 

    FBXO21 Antibody Products:

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    FBXO21 Assay Products:

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    Cloud-Clone Corp. ELISAs for FBXO21
    Cloud-Clone Corp. CLIAs for FBXO21
    Search eBioscience for ELISAs for FBXO21 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    2 InterPro protein domains:
     IPR001810 F-box_dom
     IPR011722 Hemimethylated_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry O94952

    ProtoNet protein and cluster: O94952

    UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO21           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX21_HUMAN, O94952
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXO21           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO21:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO21
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO21

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXO21:
    hsa-mir-222-3p (MIRT046784), hsa-mir-340-5p (MIRT019578), hsa-mir-92b-3p (MIRT040547), hsa-mir-96-5p (MIRT027913)

    Block miRNA regulation of human, mouse, rat FBXO21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO21 (see all 74):
    hsa-miR-579 hsa-miR-4254 hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-3916 hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO21
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO21

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXO21

    Clone
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    OriGene clones in human, mouse for FBXO21 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO21 (NM_033624)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO21

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for FBXO21
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO21 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035

    Find genes that share ontologies with FBXO21           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO21: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FBXO21 (O949523 ENSP000003281874) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    CNTNAP4Q9C0A03, ENSP000004176284I2D: score=2 STRING: ENSP00000417628
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    UBCENSP000003448184STRING: ENSP00000344818
    CNTNAP2ENSP000003547784STRING: ENSP00000354778
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process NAS10531035
    GO:0016567protein ubiquitination NAS10531035

    Find genes that share ontologies with FBXO21           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO21 (FBX21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO21 gene (2 alternative transcripts): 
    NM_015002.2  NM_033624.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427718(uc001twj.3 uc001twk.3 uc009zwq.3) ENST00000550180
    ENST00000330622 ENST00000547806 ENST00000548840 ENST00000549689 ENST00000551458

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXO21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO21 (see all 74):
    hsa-miR-579 hsa-miR-4254 hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-3916 hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO21 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO21
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO21
    Clone
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    OriGene clones in human, mouse for FBXO21 (see all 11)
    OriGene ORF clones in mouse, rat for FBXO21
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO21 (NM_033624)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO21
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO21
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO21
      QuantiFast Probe-based Assays in human, mouse, rat FBXO21

    Selected AceView cDNA sequences (see all 349):

    Z40189 AI288199 AI521172 C02365 BF058789 AI223861 BM720386 BU688948 
    AI560535 H05188 AA789145 BF439416 BX112550 AI750733 BU681154 CK824881 
    AI376852 AI566208 AU123544 AI394612 BF211311 H17999 CD518201 AI826000 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
    SP1:                    -                                                     -                           
    SP2:                    -                                         -           -                           
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FBXO21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCCAGG
    FBXO21 Expression
    About this image


    FBXO21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
     
     Eye (Sensory Organs)
             Retina
    FBXO21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO21 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO21: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO21
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    QuantiFast Probe-based Assays in human, mouse, rat FBXO21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO21 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo211 , 5 F-box protein 211, 5 87.67(n)1
    95.69(a)1
      5 (57.73 cM)5
    2316701  NM_145564.31  NP_663539.11 
     1179767705 
    chicken
    (Gallus gallus)
    Aves FBXO211 F-box protein 21 75.88(n)
    79.56(a)
      427722  XM_425297.3  XP_425297.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO216
    F-box protein 21
    72(a)
    1 ↔ 1
    LGb(2396371-2410832)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo211 F-box protein 21 63.29(n)
    60.49(a)
      100145649  NM_001127044.1  NP_001120516.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo211 F-box protein 21 63.32(n)
    61.16(a)
      567738  XM_691038.4  XP_696130.3 


    ENSEMBL Gene Tree for FBXO21 (if available)
    TreeFam Gene Tree for FBXO21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO21 (see all 1176)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835999931,2
    --117581140(+) CATAGA/TGTCAA 2 -- ds50010--------
    rs1866893251,2
    --117581144(+) GAGTCA/CATTGA 2 -- ds50010--------
    rs1169604291,2
    F--117581146(+) GTCAAT/CTGACT 2 -- ds50011Minor allele frequency- C:0.02EA 120
    rs37414701,2
    C,F,A,H--117581158(-) TAGGTT/CAAACA 2 -- ds500120Minor allele frequency- C:0.28EA NS NA CSA 3724
    rs1497252841,2
    --117581265(+) ATCAAC/TGGCAA 2 -- ds50010--------
    rs1930083681,2
    --117581725(+) TTTTTA/GAAATG 2 -- ut310--------
    rs37414691,2
    C--117582119(-) TGGCCC/GGCCAA 2 -- ut31 ese30--------
    rs1484909421,2
    C--117582213(+) TTAAAC/TAGCTC 2 -- ut310--------
    rs37414681,2
    C,F,H--117582242(-) ATTTGG/TCCCCT 2 -- ut31 ese312Minor allele frequency- T:0.13EA NS WA NA 2438
    rs1857788891,2
    --117582259(+) CTCTTC/TCTAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXO21 (117581146 - 117628336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FBXO21:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746433CNV Deletion23290073
    nsv832526CNV Loss17160897
    nsv510592CNV Loss20534489
    nsv899542CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO21
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609095    OMIM disorders: --

    1 disease for FBXO21:    
    About MalaCards
    mast cell neoplasm

    1 disease from the University of Copenhagen DISEASES database for FBXO21:
    Mast cell neoplasm

    Find genes that share disorders with FBXO21           About GenesLikeMe

    Genetic Association Database (GAD): FBXO21
    Human Genome Epidemiology (HuGE) Navigator: FBXO21 (1 document)

    Export disorders for FBXO21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO21 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with FBXO21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1 Cui Y.... Zhang L. (EMBO J. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23014 HGNC: 13592 AceView: FBXO21 Ensembl:ENSG00000135108 euGenes: HUgn23014
    ECgene: FBXO21 H-InvDB: FBXO21

    (According to HUGE)
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    HUGE: KIAA0875

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO21 gene:
    Search GeneIP for patents involving FBXO21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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