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Aliases for FBXO21 Gene

Aliases for FBXO21 Gene

  • F-Box Protein 21 2 3 5
  • FBX21 3 4
  • F-Box Only Protein 21 2
  • KIAA0875 4

External Ids for FBXO21 Gene

Previous GeneCards Identifiers for FBXO21 Gene

  • GC12P116427
  • GC12M117102
  • GC12M117364
  • GC12M115994
  • GC12M115995
  • GC12M116044
  • GC12M117581
  • GC12M114590

Summaries for FBXO21 Gene

Entrez Gene Summary for FBXO21 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO21 Gene

FBXO21 (F-Box Protein 21) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO21 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO21 Gene

Genomics for FBXO21 Gene

Regulatory Elements for FBXO21 Gene

Enhancers for FBXO21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO21 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO21 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO21 Gene

117,141,988 bp from pter
117,190,531 bp from pter
48,544 bases
Minus strand

Genomic View for FBXO21 Gene

Genes around FBXO21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO21 Gene

Proteins for FBXO21 Gene

  • Protein details for FBXO21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 21
    Protein Accession:
    Secondary Accessions:
    • B3KMF0
    • Q5BJG0
    • Q9H087

    Protein attributes for FBXO21 Gene

    628 amino acids
    Molecular mass:
    72270 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO21 Gene


neXtProt entry for FBXO21 Gene

Proteomics data for FBXO21 Gene at MOPED

Post-translational modifications for FBXO21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO21 Gene

No data available for DME Specific Peptides for FBXO21 Gene

Domains & Families for FBXO21 Gene

Gene Families for FBXO21 Gene

Protein Domains for FBXO21 Gene

Suggested Antigen Peptide Sequences for FBXO21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO21: view

Function for FBXO21 Gene

Molecular function for FBXO21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXO21: view
genes like me logo Genes that share phenotypes with FBXO21: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO21 Gene

Localization for FBXO21 Gene

Subcellular locations from

Jensen Localization Image for FBXO21 Gene COMPARTMENTS Subcellular localization image for FBXO21 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO21 Gene

Pathways & Interactions for FBXO21 Gene

SuperPathways for FBXO21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXO21 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXO21 Gene

Drugs & Compounds for FBXO21 Gene

No Compound Related Data Available

Transcripts for FBXO21 Gene

Unigene Clusters for FBXO21 Gene

F-box protein 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - -
SP2: - - -

Relevant External Links for FBXO21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO21 Gene

mRNA expression in normal human tissues for FBXO21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO21 Gene

This gene is overexpressed in Testis (17.0), Ovary (10.4), Frontal cortex (8.2), and Lung (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO21 Gene

SOURCE GeneReport for Unigene cluster for FBXO21 Gene Hs.740376

genes like me logo Genes that share expression patterns with FBXO21: view

Protein tissue co-expression partners for FBXO21 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO21 Gene

Orthologs for FBXO21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO21 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FBXO21 35
  • 92.82 (n)
  • 98.72 (a)
FBXO21 36
  • 99 (a)
(Mus musculus)
Mammalia Fbxo21 35
  • 87.67 (n)
  • 95.69 (a)
Fbxo21 16
Fbxo21 36
  • 96 (a)
(Pan troglodytes)
Mammalia FBXO21 35
  • 99.89 (n)
  • 100 (a)
FBXO21 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxo21 35
  • 87.9 (n)
  • 96.13 (a)
(Bos Taurus)
Mammalia FBXO21 36
  • 95 (a)
(Monodelphis domestica)
Mammalia FBXO21 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO21 36
  • 69 (a)
(Gallus gallus)
Aves FBXO21 35
  • 75.88 (n)
  • 79.56 (a)
FBXO21 36
  • 77 (a)
(Anolis carolinensis)
Reptilia FBXO21 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo21 35
  • 63.29 (n)
  • 60.49 (a)
(Danio rerio)
Actinopterygii fbxo21 35
  • 63.32 (n)
  • 61.16 (a)
fbxo21 36
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for FBXO21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO21 Gene

Gene Tree for FBXO21 (if available)
Gene Tree for FBXO21 (if available)

Paralogs for FBXO21 Gene

No data available for Paralogs for FBXO21 Gene

Variants for FBXO21 Gene

Sequence variations from dbSNP and Humsavar for FBXO21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11556202 - 117,177,573(-) CTTAA(A/C/G)TAATC reference, missense
rs2036311 -- 117,161,893(-) ACTGC(A/C/G)GGCTA intron-variant
rs2036312 -- 117,185,575(-) CATAT(A/G)CCTTT intron-variant
rs2036313 -- 117,185,481(-) TTCTG(C/T)TCTAA intron-variant
rs2062518 -- 117,162,473(+) aaaaa(G/T)aatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO21 Gene

Variant ID Type Subtype PubMed ID
nsv832526 CNV Loss 17160897
nsv899542 CNV Gain 21882294
esv2746433 CNV Deletion 23290073
nsv510592 CNV Loss 20534489

Variation tolerance for FBXO21 Gene

Residual Variation Intolerance Score: 9.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO21 Gene

Disorders for FBXO21 Gene

Relevant External Links for FBXO21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO21 Gene

Publications for FBXO21 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. (PMID: 26085330) Watanabe K. … Nakayama K.I. (Genes Cells 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for FBXO21 Gene

Sources for FBXO21 Gene