FBXO21 Gene
protein-coding GIFtS : 50
GCID: GC12 M117581
F-box protein 21 (Previous name: F-box only protein 21 )
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Aliasesfor FBXO21 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases F-Box Protein 21 1 2 FBX211 2 3 5 KIAA08751 3 5 F-Box Only Protein 211 2
Export aliases for FBXO21 gene to outside databases Previous GC identifers: GC12P116427 GC12M117102 GC12M117364 GC12M115994 GC12M115995 GC12M116044 GC12M114590
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Summariesfor FBXO21 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FBXO21 : This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
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Genomic Viewsfor FBXO21 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009775.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXO21 gene promoter: GR Elk-1 Sox5 STAT1 STAT1beta LUN-1 STAT1alpha AREB6 ZID GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for FBXO21 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FBXO21
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q24.22 Ensembl cytogenetic band: 12q24.22 HGNC cytogenetic band: 12q24.23 FBXO21 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M117581: view genomic region
(about GC identifiers )
Start:
117,581,146 bp from pter
End:
117,628,336 bp from pter
Size:
47,191 bases
Orientation:
minus strand
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Proteinsfor FBXO21 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952 (See
protein sequence )Recommended Name: F-box only protein 21 Size : 628 amino acids; 72270 Da
Subunit : Directly interacts with SKP1 and CUL1 (By similarity)
Sequence caution : Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp;
Secondary accessions : B3KMF0 Q5BJG0 Q9H087Alternative splicing : 2 isoforms : O94952-2 O94952-1 (May be due to a competing acceptor splice site. No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBXO21: NX_O94952 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O94952 FBXO21 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_055817.1 NP_296373.1 ENSEMBL proteins: ENSP00000414468 ENSP00000449264 ENSP00000328187 ENSP00000446973 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
FBXO21 for ontologies About GeneDecksing FBXO21 Antibody Products: Assay Products for FBXO21:
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Protein
Domains / Familiesfor FBXO21 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
FBXO21 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O94952 ProtoNet protein and cluster: O94952
UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952 Similarity : Contains 1 F-box domain
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Functionfor FBXO21 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: FBX21_HUMAN, O94952 Function : Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO21 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO21 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FBXO21 (NM_033624 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO21 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO21
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO21
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
FBXO21 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for FBXO21 :
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Pathways & Interactionsfor FBXO21 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO21 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/8 Interacting proteins for FBXO21 (O94952 3 ENSP00000328187 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
FBXO21 for ontologies About GeneDecksing
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Drugs & Compoundsfor FBXO21 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for FBXO21 Search CenterWatch for drugs/clinical trials and news about FBXO21 / FBX21
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Transcriptsfor FBXO21 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FBXO21 gene (2 alternative transcripts): NM_015002.2 NM_033624.2 Unigene Cluster for FBXO21:
F-box protein 21 Hs.740376 [show with all ESTs ] Unigene Representative Sequence: NM_033624 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000427718 (uc001twj.3 uc001twk.3 uc009zwq.3 ) ENST00000550180 ENST00000330622 ENST00000547806 ENST00000548840 ENST00000549689 ENST00000551458 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO21 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO21 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): FBXO21 (NM_033624 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXO21 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO21
Additional cDNA sequence: AB020682.1 AF174601.1 AK001699.1 AK074714.1 AK308141.1 AK314573.1 AL136899.1 BC034045.1 BC042333.1 BC091496.1
15 DOTS entries : DT.448486 DT.91753090
DT.95355341 DT.95145079 DT.100822829 DT.101967466 DT.121151082 DT.97859016 DT.95073284 DT.100665658 DT.121151006 DT.121151089 DT.100702617 DT.101966680 DT.92032018 24/349 AceView cDNA sequences (see all 349 ):
AI867471 N52366 CD678471 BI792373 BU688948 BF211311 AI560535 T10762 BU681154 CD518201 AA317076 CD364571 AA444045 AI376852 W72224 CB132899 CA866157 BX112550 AI566208 AI223861 CB119361 AW663975 BG743296 AI209113 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 SP1 :       -                   -           SP2 :       -               -     -           SP3 :                                   SP4 :                                   SP5 :                                  
ECgene alternative splicing isoforms for FBXO21
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Expression for FBXO21 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FBXO21 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGGCTCCAGG
About this image FBXO21 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Retina Eye Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See FBXO21 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXO21 SOURCE GeneReport for Unigene cluster: Hs.740376 SABiosciences Expression via Pathway-Focused PCR Array including FBXO21 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FBXO21Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat FBXO21 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FBXO21 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FBXO21 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO21
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Orthologsfor FBXO21 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for FBXO21 gene from 5/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for FBXO21 (if available)TreeFam Gene Tree for FBXO21 (if available)
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Paralogsfor FBXO21 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor FBXO21 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for FBXO21 (117581146 - 117628336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FBXO21 1 CNV : 4789
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FBXO21
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Disorders
/ Diseasesfor FBXO21 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
FBXO21 for disorders About GeneDecksing
OMIM gene information: 609095
OMIM disorders : --1 disease for FBXO21 : About MalaCards mast cell neoplasm 1 disease from the University of Copenhagen DISEASES database for FBXO21 :Mast cell neoplasm Human Genome Epidemiology (HuGE) Navigator: FBXO21 (1 document)Export disorders for FBXO21 gene to outside databases
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Publicationsfor FBXO21 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FBXO21 gene, integrated from 9 sources (see all 18 ): (articles sorted by number of sources associating them with FBXO21) Utopia : connect your pdf to the dynamic world of online information
Identification of a family of human F-box proteins. (PubMed id 10531035) 1 , 2 , 3 Cenciarelli C....Pagano M. (1999) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485) 1 , 2 , 3 Nagase T....Ohara O. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590) 1 Emanuele M.J....Elledge S.J. (2011) Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572) 1 Lee K.A....Doedens J.R. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for FBXO21 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing FBXO21 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing FBXO21 gene
(According to HUGE )
About This Section
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Specialized Databases showing FBXO21 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for FBXO21 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for FBXO21 gene: Search GeneIP for patents involving FBXO21 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FBXO21 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for FBXO21 OriGene shRNA RFP for FBXO21 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for FBXO21 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for FBXO21 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FBXO21 OriGene 3'-UTR Clone for FBXO21 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO21 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for FBXO21 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FBXO21 OriGene Custom Protein Services for FBXO21 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXO21 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing FBXO21 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat FBXO21 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat FBXO21 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat FBXO21 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat FBXO21
Search Tocris compounds for FBXO21
FBXO21 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO21
Search ThermoFisher Antibodies for FBXO21
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FBXO21
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