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Aliases for FBXO21 Gene

Aliases for FBXO21 Gene

  • F-Box Protein 21 2 3 5
  • F-Box Only Protein 21 2 3
  • FBX21 3 4
  • KIAA0875 4

External Ids for FBXO21 Gene

Previous GeneCards Identifiers for FBXO21 Gene

  • GC12P116427
  • GC12M117102
  • GC12M117364
  • GC12M115994
  • GC12M115995
  • GC12M116044
  • GC12M117581
  • GC12M114590

Summaries for FBXO21 Gene

Entrez Gene Summary for FBXO21 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO21 Gene

FBXO21 (F-Box Protein 21) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXO21 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO21 Gene

Genomics for FBXO21 Gene

Regulatory Elements for FBXO21 Gene

Enhancers for FBXO21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F117141 1.3 Ensembl ENCODE 20.3 +47.7 47721 2.2 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF207 FOS SP3 SP5 JUNB FBXO21 LOC105370010
GH12F117189 1 ENCODE 20 +0.6 585 2.3 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF207 ZNF143 ZNF548 SP3 FBXW8 FBXO21 MED13L LOC105370010
GH12F117140 0.9 Ensembl ENCODE 20.6 +49.7 49731 0.4 JUND ATF3 ZMYM3 NR3C1 PRDM1 TCF7L2 NR2F2 YY1 FBXO21 LOC105370010
GH12F117155 0.9 ENCODE 20 +35.1 35081 0.3 ELF3 PKNOX1 ARID4B ZNF48 ZNF2 RAD21 RFX5 SLC30A9 GLIS2 ZNF143 FBXO21 LOC105370010
GH12F117158 0.7 ENCODE 21.9 +31.3 31275 2.2 CEBPB MAX SIN3A EP300 ZNF664 MAFF GATA3 FOS MAFK TCF7L2 FBXO21 LOC105370010
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO21 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091260 531 2001 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF207 ZNF143 ZNF548 SP3

Genomic Location for FBXO21 Gene

Chromosome:
12
Start:
117,141,988 bp from pter
End:
117,190,531 bp from pter
Size:
48,544 bases
Orientation:
Minus strand

Genomic View for FBXO21 Gene

Genes around FBXO21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO21 Gene

Proteins for FBXO21 Gene

  • Protein details for FBXO21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94952-FBX21_HUMAN
    Recommended name:
    F-box only protein 21
    Protein Accession:
    O94952
    Secondary Accessions:
    • B3KMF0
    • Q5BJG0
    • Q9H087

    Protein attributes for FBXO21 Gene

    Size:
    628 amino acids
    Molecular mass:
    72270 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO21 Gene

Post-translational modifications for FBXO21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO21 Gene

Domains & Families for FBXO21 Gene

Gene Families for FBXO21 Gene

Protein Domains for FBXO21 Gene

Suggested Antigen Peptide Sequences for FBXO21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94952

UniProtKB/Swiss-Prot:

FBX21_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO21: view

Function for FBXO21 Gene

Molecular function for FBXO21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXO21: view
genes like me logo Genes that share phenotypes with FBXO21: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO21 Gene

Localization for FBXO21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO21 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
genes like me logo Genes that share ontologies with FBXO21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO21 Gene

Pathways & Interactions for FBXO21 Gene

genes like me logo Genes that share pathways with FBXO21: view

Gene Ontology (GO) - Biological Process for FBXO21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXO21: view

No data available for SIGNOR curated interactions for FBXO21 Gene

Transcripts for FBXO21 Gene

Unigene Clusters for FBXO21 Gene

F-box protein 21:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13
SP1: - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for FBXO21 Gene

GeneLoc Exon Structure for
FBXO21
ECgene alternative splicing isoforms for
FBXO21

Expression for FBXO21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO21 Gene

This gene is overexpressed in Testis (17.0), Ovary (10.4), Frontal cortex (8.2), and Lung (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO21 Gene



Protein tissue co-expression partners for FBXO21 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO21 Gene:

FBXO21

SOURCE GeneReport for Unigene cluster for FBXO21 Gene:

Hs.740376
genes like me logo Genes that share expression patterns with FBXO21: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO21 Gene

Orthologs for FBXO21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO21 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia FBXO21 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO21 34 35
  • 92.82 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo21 34
  • 87.9 (n)
mouse
(Mus musculus)
Mammalia Fbxo21 34 16 35
  • 87.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO21 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO21 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO21 34 35
  • 75.88 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO21 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo21 34
  • 63.29 (n)
zebrafish
(Danio rerio)
Actinopterygii fbxo21 34 35
  • 63.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for FBXO21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO21 Gene

ENSEMBL:
Gene Tree for FBXO21 (if available)
TreeFam:
Gene Tree for FBXO21 (if available)

Paralogs for FBXO21 Gene

No data available for Paralogs for FBXO21 Gene

Variants for FBXO21 Gene

Sequence variations from dbSNP and Humsavar for FBXO21 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10161089 -- 117,178,493(+) TCCAG(C/T)GGTTT intron-variant
rs10161283 -- 117,178,345(+) CACCA(C/T)CAGCA intron-variant
rs10531626 -- 117,157,636(+) AAAAC(-/ACT)AGAAG intron-variant
rs10532210 -- 117,162,272(+) AGGAG(-/AAG)GTGCC intron-variant
rs1060232 -- 117,144,858(-) GGCGT(C/T)TTCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXO21 Gene

Variant ID Type Subtype PubMed ID
nsv832526 CNV loss 17160897
nsv510592 CNV deletion 20534489
nsv1145628 CNV deletion 24896259
esv3630863 CNV gain 21293372
esv2746433 CNV deletion 23290073
dgv521e212 CNV loss 25503493
dgv520e212 CNV loss 25503493
dgv2899n54 CNV loss 21841781

Variation tolerance for FBXO21 Gene

Residual Variation Intolerance Score: 9.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO21 Gene

Disorders for FBXO21 Gene

Relevant External Links for FBXO21

Genetic Association Database (GAD)
FBXO21
Human Genome Epidemiology (HuGE) Navigator
FBXO21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO21

No disorders were found for FBXO21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO21 Gene

Publications for FBXO21 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for FBXO21 Gene

Sources for FBXO21 Gene

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