Aliases for FBXO21 Gene
External Ids for FBXO21 Gene
- HGNC: 13592
- Entrez Gene: 23014
- Ensembl: ENSG00000135108
- OMIM: 609095
- UniProtKB: O94952
Previous GeneCards Identifiers for FBXO21 Gene
- GC12P116427
- GC12M117102
- GC12M117364
- GC12M115994
- GC12M115995
- GC12M116044
- GC12M117581
- GC12M114590
Summaries for FBXO21 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXO21 Gene
FBXO21 (F-Box Protein 21) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXO21 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO21 Gene
Genomics for FBXO21 Gene
Regulatory Elements for FBXO21 Gene
Enhancers for FBXO21 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G117141 | 1 | ENCODE | 20.3 | +47.7 | 47721 | 2.2 | PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ELK1 ZNF207 | FBXO21 LOC105370010 |
| GH12G117189 | 1 | ENCODE | 20 | +0.6 | 585 | 2.3 | PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ZNF548 SP3 | FBXW8 FBXO21 MED13L LOC105370010 |
| GH12G117155 | 0.9 | ENCODE | 20 | +35.1 | 35081 | 0.3 | HDGF PKNOX1 ARID4B ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 FOS ZNF263 | FBXO21 LOC105370010 |
| GH12G117151 | 0.7 | ENCODE | 20.1 | +39.3 | 39261 | 0.2 | CTCF ATF1 RB1 RNF2 L3MBTL2 REST RAD21 IKZF1 SMC3 CREM | FBXO21 LOC105370010 |
| GH12G117158 | 0.6 | ENCODE | 22 | +31.3 | 31275 | 2.2 | MAX CEBPB SIN3A EP300 ZNF664 MAFF GATA3 FOS MAFK TCF7L2 | FBXO21 LOC105370010 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO21 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXO21 gene promoter:
Regulatory Element Products
Genomic Location for FBXO21 Gene
- Chromosome:
- 12
- Start:
- 117,141,988 bp from pter
- End:
- 117,190,531 bp from pter
- Size:
- 48,544 bases
- Orientation:
- Minus strand
Genomic View for FBXO21 Gene
Genes around FBXO21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.22 by Ensembl
- 12q24.22 by Entrez Gene
- 12q24.22 by HGNC
FBXO21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO21 Gene
Proteins for FBXO21 Gene
-
Protein details for FBXO21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O94952-FBX21_HUMAN
- Recommended name:
- F-box only protein 21
- Protein Accession:
- O94952
- B3KMF0
- Q5BJG0
- Q9H087
Protein attributes for FBXO21 Gene
- Size:
- 628 amino acids
- Molecular mass:
- 72270 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=CAB66833.2; Type=Erroneous termination; Positions=81; Note=Translated as Trp.; Evidence={ECO:0000305};
Protein Expression for FBXO21 Gene
Post-translational modifications for FBXO21 Gene
Other Protein References for FBXO21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXO21
- Invitrogen Antibodies for FBXO21
- antibodies-online Antibodies for FBXO21: See all 72
- GeneTex FBXO21 antibody for FBXO21
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FBXO21
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- antibodies-online Proteins for FBXO21: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO21
Assay Products
- antibodies-online Kits for FBXO21: See all 15
No data available for DME Specific Peptides for FBXO21 Gene
Domains & Families for FBXO21 Gene
Gene Families for FBXO21 Gene
- HGNC:
Protein Domains for FBXO21 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO21 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO21 Gene
Function for FBXO21 Gene
Molecular function for FBXO21 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXO21 Gene
- GenomeRNAi human phenotypes for FBXO21:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased ionizing radiation sensitivity
- Decreased p24 protein expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability with paclitaxel
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO21 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO21 gene
- Search ViGene Biosciences for FBXO21
CRISPR Products
-
OriGene CRISPR knockouts for FBXO21
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO21
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miRNA for FBXO21 Gene
- miRTarBase miRNAs that target FBXO21
-
- hsa-mir-340-5p (MIRT019578)
- hsa-mir-96-5p (MIRT027913)
- hsa-mir-92b-3p (MIRT040547)
- hsa-mir-222-3p (MIRT046784)
- hsa-mir-20a-5p (MIRT440657)
- hsa-mir-106b-5p (MIRT440658)
- hsa-mir-1273h-3p (MIRT476889)
- hsa-mir-524-5p (MIRT476890)
- hsa-mir-520d-5p (MIRT476891)
- hsa-mir-6716-5p (MIRT476892)
- hsa-mir-122-5p (MIRT476893)
- hsa-mir-504-3p (MIRT476894)
- hsa-mir-4771 (MIRT476895)
- hsa-mir-3166 (MIRT476896)
- hsa-mir-1324 (MIRT476897)
- hsa-mir-6783-5p (MIRT476898)
- hsa-mir-6514-5p (MIRT476899)
- hsa-mir-4524b-3p (MIRT476900)
- hsa-mir-6870-3p (MIRT658208)
- hsa-mir-4753-3p (MIRT658209)
- hsa-mir-6762-5p (MIRT658210)
- hsa-mir-6845-5p (MIRT658211)
- hsa-mir-3926 (MIRT658212)
- hsa-mir-325 (MIRT658213)
- hsa-mir-628-3p (MIRT658214)
- hsa-mir-605-5p (MIRT658215)
- hsa-mir-519d-3p (MIRT727671)
- hsa-mir-93-5p (MIRT727672)
- hsa-mir-20b-5p (MIRT727673)
- hsa-mir-17-5p (MIRT727674)
miRNA Products
- Search ViGene Biosciences for FBXO21
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXO21
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-
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-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO21 Gene
Localization for FBXO21 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | NAS | 10531035 |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO21 Gene
Pathways & Interactions for FBXO21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXO21 Gene
4 Reactome pathways for FBXO21 Gene
Interacting Proteins for FBXO21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | NAS | 10531035 |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXO21 Gene
Transcripts for FBXO21 Gene
mRNA/cDNA for FBXO21 Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (349) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO21
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO21
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miRNA Products
- Search ViGene Biosciences for FBXO21
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXO21
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO21 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: |
Expression for FBXO21 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
-
Gonad
- XY Germ Cells Testis Cord
- Eye (Sensory Organs)
This gene is overexpressed in Testis (17.0), Ovary (10.4), Frontal cortex (8.2), and Lung (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO21 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO21 Gene:
FBXO21SOURCE GeneReport for Unigene cluster for FBXO21 Gene:
Hs.740376Evidence on tissue expression from TISSUES for FBXO21 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for FBXO21
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO21 Gene
Orthologs for FBXO21 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO21 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO21 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO21 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo21 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo21 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO21 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FBXO21 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO21 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO21 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo21 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxo21 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXO21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO21 Gene
No data available for Paralogs for FBXO21 Gene
Variants for FBXO21 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000091136 | -- | 117,190,355(+) | TCACC(C/T)GGCAG | upstream-variant-2KB, reference, synonymous-codon | |
| rs1000092165 | -- | 117,149,542(+) | CTGGT(A/G)AGGCC | intron-variant | |
| rs1000098367 | -- | 117,183,788(+) | GTCTC(C/T)TATTT | intron-variant | |
| rs1000101860 | -- | 117,144,313(+) | CTTGG(C/T)GGGCC | utr-variant-3-prime | |
| rs1000152550 | -- | 117,144,489(+) | ATGAA(C/G)TGGTC | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2899n54 | CNV | loss | 21841781 |
| dgv520e212 | CNV | loss | 25503493 |
| dgv521e212 | CNV | loss | 25503493 |
| esv2746433 | CNV | deletion | 23290073 |
| esv3630863 | CNV | gain | 21293372 |
| nsv1145628 | CNV | deletion | 24896259 |
| nsv510592 | CNV | deletion | 20534489 |
| nsv832526 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
9.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.65;
13.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO21
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO21 Gene
Disorders for FBXO21 Gene
Relevant External Links for FBXO21
No disorders were found for FBXO21 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO21 Gene
Publications for FBXO21 Gene
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
Products for FBXO21 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO21 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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