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Aliases for FBXO2 Gene

Aliases for FBXO2 Gene

  • F-Box Protein 2 2 3
  • FBX2 3 4 6
  • Organ Of Corti Protein 1 2 3
  • F-Box Only Protein 2 2 3
  • NFB42 3 6
  • FBG1 3 6
  • F-Box Gene 1 3
  • Fbs1 3
  • OCP1 3

External Ids for FBXO2 Gene

Previous Symbols for FBXO2 Gene

  • OCP1

Summaries for FBXO2 Gene

Entrez Gene Summary for FBXO2 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO2 Gene

FBXO2 (F-Box Protein 2) is a Protein Coding gene. Diseases associated with FBXO2 include benign paroxysmal positional nystagmus and herpes simplex. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and glycoprotein binding. An important paralog of this gene is NCCRP1.

UniProtKB/Swiss-Prot for FBXO2 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).

Gene Wiki entry for FBXO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO2 Gene

Genomics for FBXO2 Gene

Genomic Location for FBXO2 Gene

Start:
11,647,868 bp from pter
End:
11,655,785 bp from pter
Size:
7,918 bases
Orientation:
Minus strand

Genomic View for FBXO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO2 Gene

Regulatory Elements for FBXO2 Gene

Proteins for FBXO2 Gene

  • Protein details for FBXO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK22-FBX2_HUMAN
    Recommended name:
    F-box only protein 2
    Protein Accession:
    Q9UK22
    Secondary Accessions:
    • B2R7K7
    • Q5TGY0
    • Q6FGJ7
    • Q8TB29
    • Q9UKC6

    Protein attributes for FBXO2 Gene

    Size:
    296 amino acids
    Molecular mass:
    33328 Da
    Quaternary structure:
    • Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).

neXtProt entry for FBXO2 Gene

Proteomics data for FBXO2 Gene at MOPED

Post-translational modifications for FBXO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO2 Gene

Domains for FBXO2 Gene

Gene Families for FBXO2 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO2 Gene

UniProtKB/Swiss-Prot:

FBX2_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q9UK22
  • Contains 1 FBA (F-box associated) domain.:
    • Q9UK22
genes like me logo Genes that share domains with FBXO2: view

Function for FBXO2 Gene

Molecular function for FBXO2 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).

Gene Ontology (GO) - Molecular Function for FBXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IEA --
GO:0001948 glycoprotein binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding IPI 25416956
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with FBXO2: view
genes like me logo Genes that share phenotypes with FBXO2: view

Animal Models for FBXO2 Gene

MGI Knock Outs for FBXO2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO2 Gene

Localization for FBXO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO2 Gene

Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO2 Gene COMPARTMENTS Subcellular localization image for FBXO2 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol ISS --
GO:0016020 membrane --
GO:0019005 SCF ubiquitin ligase complex ISS --
GO:0031090 organelle membrane IEA --
genes like me logo Genes that share ontologies with FBXO2: view

Pathways for FBXO2 Gene

genes like me logo Genes that share pathways with FBXO2: view

UniProtKB/Swiss-Prot Q9UK22-FBX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10531035
GO:0006508 proteolysis TAS 10531035
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0006516 glycoprotein catabolic process ISS --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with FBXO2: view

Transcripts for FBXO2 Gene

Unigene Clusters for FBXO2 Gene

F-box protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FBXO2 Gene

GeneLoc Exon Structure for
FBXO2
ECgene alternative splicing isoforms for
FBXO2

Expression for FBXO2 Gene

mRNA expression in normal human tissues for FBXO2 Gene

mRNA differential expression in normal tissues according to GTEx for FBXO2 Gene

This gene is overexpressed in Brain - Amygdala (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO2 Gene

SOURCE GeneReport for Unigene cluster for FBXO2 Gene Hs.132753

genes like me logo Genes that share expressions with FBXO2: view

Orthologs for FBXO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO2 36
  • 99.55 (n)
  • 99.32 (a)
FBXO2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO2 36
  • 90.3 (n)
  • 91.78 (a)
FBXO2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO2 36
  • 89.98 (n)
  • 88.85 (a)
FBXO2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo2 36
  • 87.37 (n)
  • 89.08 (a)
Fbxo2 16
Fbxo2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO2 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo2 36
  • 87.56 (n)
  • 90.41 (a)
chicken
(Gallus gallus)
Aves FBXO2 36
  • 70.04 (n)
  • 71.31 (a)
FBXO2 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO2 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733128 36
  • 58.09 (n)
  • 56.96 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo44 37
  • 36 (a)
ManyToMany
si:dkey-147f3.4 37
  • 30 (a)
ManyToMany
si:dkey-147f3.4 37
  • 38 (a)
ManyToMany
si:dkey-147f3.8 37
  • 23 (a)
ManyToMany
si:rp71-1k13.6 37
  • 39 (a)
ManyToMany
zgc:100832 37
  • 43 (a)
ManyToMany
zgc:114081 37
  • 33 (a)
ManyToMany
zgc:114174 37
  • 34 (a)
ManyToMany
zgc:153722 37
  • 39 (a)
ManyToMany
zgc:173570 37
  • 40 (a)
ManyToMany
zgc:175088 36
  • 60.12 (n)
  • 57.23 (a)
zgc:175088 37
  • 56 (a)
ManyToMany
Species with no ortholog for FBXO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO2 Gene

ENSEMBL:
Gene Tree for FBXO2 (if available)
TreeFam:
Gene Tree for FBXO2 (if available)

Paralogs for FBXO2 Gene

Paralogs for FBXO2 Gene

Selected SIMAP similar genes for FBXO2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXO2: view

Variants for FBXO2 Gene

Sequence variations from dbSNP and Humsavar for FBXO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9614 - 11,650,504(-) GAGCA(A/C)GCGGC reference, missense, nc-transcript-variant
rs1055547 -- 11,648,679(-) CCTCC(A/G)CTCTC utr-variant-3-prime, nc-transcript-variant
rs1133892 -- 11,648,805(-) GACTA(C/T)GGGCC reference, synonymous-codon, nc-transcript-variant
rs2103665 -- 11,652,052(-) cagga(A/G)ttgga intron-variant
rs2235658 -- 11,649,707(-) GGGAA(A/C)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO2 Gene

Variant ID Type Subtype PubMed ID
nsv832758 CNV Loss 17160897
dgv139n71 CNV Loss 21882294
nsv515826 CNV Loss 19592680
nsv871014 CNV Gain 21882294
nsv871850 CNV Loss 21882294
nsv521468 CNV Loss 19592680

Relevant External Links for FBXO2 Gene

HapMap Linkage Disequilibrium report
FBXO2
Human Gene Mutation Database (HGMD)
FBXO2

Disorders for FBXO2 Gene

(2) University of Copenhagen DISEASES for FBXO2 Gene

(1) Novoseek inferred disease relationships for FBXO2 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 40.5 1
genes like me logo Genes that share disorders with FBXO2: view

No data available for UniProtKB/Swiss-Prot for FBXO2 Gene

Publications for FBXO2 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 23
  5. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 23

Products for FBXO2 Gene

Sources for FBXO2 Gene

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