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FBXO2 Gene

protein-coding   GIFtS: 57
GCID: GC01M011708

F-Box Protein 2

(Previous names: F-box only protein 2, organ of Corti protein 1)
(Previous symbol: OCP1)
  See FBXO2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 21 2     FBG12 5
FBX22 3 5     NFB422 5
OCP11 2     Fbs12
F-Box Only Protein 21 2     F-Box Gene 12
Organ Of Corti Protein 11 2     

External Ids:    HGNC: 135811   Entrez Gene: 262322   Ensembl: ENSG000001166617   OMIM: 6071125   UniProtKB: Q9UK223   

Export aliases for FBXO2 gene to outside databases

Previous GC identifers: GC01M011669 GC01M011552 GC01M011317 GC01M011417 GC01M011637 GC01M010862


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO2 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa)
protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic
state. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO2 Gene:
FBXO2 (F-box protein 2) is a protein-coding gene. Diseases associated with FBXO2 include benign paroxysmal positional nystagmus, and menieres disease. GO annotations related to this gene include ubiquitin-protein ligase activity and glycoprotein binding. An important paralog of this gene is FBXO17.

UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the
endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and
binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their
ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins
that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins,
preferentially those of the high-mannose type (By similarity)

Gene Wiki entry for FBXO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO2 gene promoter:
         Max1   Elk-1   Olf-1   Pax-2   AP-4   Pax-2a   Nkx2-5   PPAR-alpha   Pax-3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO2 promoter sequence
   Search Chromatin IP Primers for FBXO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.21

FBXO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011708:  view genomic region     (about GC identifiers)

Start:
11,708,418 bp from pter      End:
11,715,842 bp from pter
Size:
7,425 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22 (See protein sequence)
Recommended Name: F-box only protein 2  
Size: 296 amino acids; 33328 Da
Subunit: Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as
heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity)
Secondary accessions: B2R7K7 Q5TGY0 Q6FGJ7 Q8TB29 Q9UKC6

Explore the universe of human proteins at neXtProt for FBXO2: NX_Q9UK22

Explore proteomics data for FBXO2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036300.2  
    ENSEMBL proteins: 
     ENSP00000346240   ENSP00000473649  
    Reactome Protein details: Q9UK22

    FBXO2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    3 InterPro protein domains:
     IPR007397 F-box-assoc_dom
     IPR008979 Galactose-bd-like
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UK22

    ProtoNet protein and cluster: Q9UK22

    1 Blocks protein domain: IPB007397 F-box associated region

    UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 FBA (F-box associated) domain


    Find genes that share domains with FBXO2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX2_HUMAN, Q9UK22
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the
    endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and
    binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their
    ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins
    that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins,
    preferentially those of the high-mannose type (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IEA--
    GO:0001948glycoprotein binding IEA--
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with FBXO2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fbxo2):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    Find genes that share phenotypes with FBXO2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fbxo2tm1Hlp for FBXO2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO2
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FBXO2:
    hsa-miR-1207-3p hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX2_HUMAN, Q9UK22: Cytoplasm (By similarity). Microsome membrane; Peripheral membrane protein; Cytoplasmic side
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endoplasmic reticulum3
    nucleus2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol ISS--
    GO:0019005SCF ubiquitin ligase complex ISS--
    GO:0031090organelle membrane IEA--
    GO:0043197dendritic spine IEA--

    Find genes that share ontologies with FBXO2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXO2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with FBXO2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FBXO2
        Antigen processing: Ubiquitination & Proteasome degradation


    2 Kegg Pathways  (Kegg details for FBXO2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO2: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO2 (Q9UK223 ENSP000003462404) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=4 STRING: ENSP00000231487
    BACE1P568173, ENSP000003185854I2D: score=2 STRING: ENSP00000318585
    VCPP550723, ENSP000003517774I2D: score=2 STRING: ENSP00000351777
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10531035
    GO:0006508proteolysis TAS10531035
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0006516glycoprotein catabolic process ISS--
    GO:0008285negative regulation of cell proliferation IEA--

    Find genes that share ontologies with FBXO2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO2 (FBX2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO2 gene: 
    NM_012168.5  

    Unigene Cluster for FBXO2:

    F-box protein 2
    Hs.132753  [show with all ESTs]
    Unigene Representative Sequence: NM_012168
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354287(uc009vnb.1 uc001asj.3 uc009vna.3) ENST00000471501
    ENST00000466919 ENST00000465901 ENST00000475961
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate FBXO2:
    hsa-miR-1207-3p hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXO2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXO2
      QuantiFast Probe-based Assays in human, mouse, rat FBXO2

    Additional mRNA sequence: 

    AF174594.1 AF187318.1 AK308531.1 AK313019.1 BC014957.1 BC025233.1 BC096747.1 BC127894.1 
    CR542110.1 

    5 DOTS entries:

    DT.453903  DT.97790134  DT.91707486  DT.95285528  DT.95325489 

    Selected AceView cDNA sequences (see all 92):

    AW135504 CK819341 AW341533 BC025233 BI763235 BE672326 BQ953154 BM699742 
    AI928563 BI966703 AW160505 BM142251 AI767575 AA583586 AA063432 CB154741 
    AF187318 BM666617 BG900236 AW341600 BM831661 BI602337 AW162121 CR542110 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:              -     -                                   -                     
    SP2:                                            -           -                     
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for FBXO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGGACGG
    FBXO2 Expression
    About this image

    FBXO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132753
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo21 , 5 F-box protein 21, 5 87.37(n)1
    89.08(a)1
      4 (78.68 cM)5
    2309041  NM_176848.11  NP_789818.11 
     1481606215 
    chicken
    (Gallus gallus)
    Aves FBXO21 F-box protein 2 70.04(n)
    71.31(a)
      419495  XM_004947514.1  XP_004947571.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO26
    F-box protein 2
    67(a)
    1 ↔ 1
    GL343881.1(106570-115996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017331281 F-box only protein 2-like 58.09(n)
    56.96(a)
      101733128  XM_004916520.1  XP_004916577.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1750881 zgc:175088 60.12(n)
    57.23(a)
      559776  NM_001113798.1  NP_001107270.1 


    ENSEMBL Gene Tree for FBXO2 (if available)
    TreeFam Gene Tree for FBXO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO2 gene
    FBXO172  FBXO62  FBXO272  FBXO442  NCCRP12  
    4 SIMAP similar genes for FBXO2 using alignment to 2 protein entries:     FBX2_HUMAN (see all proteins):
    FBXO44    FBXO6    FBXO27    FBXO17

    Find genes that share paralogs with FBXO2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO2 (see all 140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168122251,2
    C,F--11707990(+) GCCTCT/CACCCT 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1391362741,2
    C--11708377(+) TATGCC/TGGGGG 1 -- ds50010--------
    rs1899423301,2
    --11708425(+) TTTATC/GCATTT 1 -- ut310--------
    rs1150077071,2
    C,F--11708537(+) CTCACG/ACCCTC 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs751799871,2
    C,F--11708678(+) CTATGG/AACTAA 1 -- ut311Minor allele frequency- A:0.03EA 120
    rs10555471,2
    C,F,A,H--11708736(-) CCTCCA/GCTCTC 1 -- ut31 ese323Minor allele frequency- G:0.45EA MN NS NA WA EU 4930
    rs1815871191,2
    C--11708747(+) CAGGGA/TCGCTC 1 -- ut310--------
    rs1412665991,2
    C,F--11708856(+) ACGCCC/TGGCCC 2 P syn12Minor allele frequency- T:0.00NA EU 5769
    rs1114561011,2
    C,F--11708916(+) GCCTCG/AGAGGT 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs2017729331,2
    C--11708920(+) CGGAGA/GTCCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FBXO2 (11708418 - 11715842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FBXO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515826CNV Loss19592680
    nsv832758CNV Loss17160897
    nsv521468CNV Loss19592680
    nsv871850CNV Loss21882294
    dgv139n71CNV Loss21882294
    nsv871014CNV Gain21882294

    Human Gene Mutation Database (HGMD): FBXO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO2
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607112    OMIM disorders: --

    3 diseases for FBXO2:    
    About MalaCards
    benign paroxysmal positional nystagmus    menieres disease    herpes simplex

    2 diseases from the University of Copenhagen DISEASES database for FBXO2:
    Benign paroxysmal positional nystagmus     Meniere's disease

    Find genes that share disorders with FBXO2           About GenesLikeMe

    1 Novoseek inferred disease relationship for FBXO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 40.5 2 15010529 (1)


    Export disorders for FBXO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FBXO2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with FBXO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 9 Glenn K.A.... Paulson H.L. (J. Biol. Chem. 2008)
    6. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 9 Ilyin G.P....Guguen-Guillouzo C. (Gene 2002)
    7. The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy. (PubMed id 22917612)1 Gordon K.L....Gonzalez-Alegre P. (Neuroscience 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    10. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1 Gorbea C.... Rechsteiner M. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26232 HGNC: 13581 AceView: FBXO2 Ensembl:ENSG00000116661 euGenes: HUgn26232
    ECgene: FBXO2 Kegg: 26232 H-InvDB: FBXO2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FBXO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FBXO2 gene:
    Search GeneIP for patents involving FBXO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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