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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO2 Gene

protein-coding   GIFtS: 57
GCID: GC01M011708

F-box protein 2

(Previous names: F-box only protein 2, organ of Corti protein 1 )
(Previous symbol: OCP1)
 Explore 8 diseases affiliated with
FBXO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FBXO2    

Aliases
for FBXO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
F-Box Protein 21 2     FBG12 5
FBX21 2 3 5     NFB422 5
Fbs11 2     Fbg11
OCP11 2     Nfb421
F-Box Only Protein 21 2     F-Box Gene 12
Organ Of Corti Protein 11 2     

External Ids:    HGNC: 135811   Entrez Gene: 262322   Ensembl: ENSG000001166617   OMIM: 6071125   UniProtKB: Q9UK223   

Export aliases for FBXO2 gene to outside databases

Previous GC identifers: GC01M011669 GC01M011552 GC01M011317 GC01M011417 GC01M011637 GC01M010862


Summaries
for FBXO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FBXO2:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs
class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous
system and may play a role in maintaining neurons in a postmitotic state. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that
mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic
reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains
on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and
subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been
retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the
high-mannose type (By similarity)

Gene Wiki entry for FBXO2


Genomic Views
for FBXO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO2 gene promoter:
         Max1   Elk-1   Olf-1   Pax-2   AP-4   Pax-2a   Nkx2-5   PPAR-alpha   Pax-3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBXO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.21

FBXO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M011708:  view genomic region     (about GC identifiers)

Start:
 11,708,424 bp from pter      End:
 11,715,842 bp from pter
Size:
 7,419 bases      Orientation:
 minus strand

Proteins
for FBXO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22 (See protein sequence)
Recommended Name: F-box only protein 2  
Size: 296 amino acids; 33328 Da
Subunit: Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as
heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity)
Subcellular location: Cytoplasm (By similarity). Microsome membrane; Peripheral membrane protein; Cytoplasmic side (By
similarity)
Secondary accessions: B2R7K7 Q5TGY0 Q6FGJ7 Q8TB29 Q9UKC6

Explore the universe of human proteins at neXtProt for FBXO2: NX_Q9UK22

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UK22

    • FBXO2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036300.2  
    ENSEMBL proteins: 
     ENSP00000346240  
    Reactome Protein details: Q9UK22
    Human Recombinant Protein Products: 
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    Novus Biologicals FBXO2 Protein
    Novus Biologicals FBXO2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBXO2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005792microsome ----
    GO:0005829cytosol ISS--
    GO:0016020membrane ----
    GO:0019005SCF ubiquitin ligase complex ISS--


    FBXO2 for ontologies           About GeneDecksing



    FBXO2 Antibody Products: 
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    Abcam antibodies for FBXO2 
    Uscn Antibodies for FBXO2
    ThermoFisher Antibody for FBXO2

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    Uscn ELISAs and CLIAs for FBXO2

    Protein Domains /
    Families
    for FBXO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FBXO2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007397 F-box-assoc_dom
     IPR008979 Galactose-bd-like
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9UK22

    ProtoNet protein and cluster: Q9UK22

    1 Blocks protein family: IPB007397 F-box associated region

    UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
    Similarity: Contains 1 F-box domain
    Similarity: Contains 1 FBA (F-box associated) domain


    Function
    for FBXO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that
    mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic
    reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains
    on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and
    subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been
    retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the
    high-mannose type (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO2:
    hsa-miR-1207-3p hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FBXO2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO2 (see all 7)
    OriGene shRNA RFP: FBXO2
    OriGene siRNA: FBXO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FBXO2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO2 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO2 (NM_033624)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO2 

    Cell Line
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    Search LifeMap BioReagents cell lines for FBXO2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IEA--
    GO:0001948glycoprotein binding IEA--
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--


    FBXO2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fbxo2tm1Hlp for FBXO2
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fbxo2):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    FBXO2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FBXO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for FBXO2
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    2         Kegg Pathways  (Kegg details for FBXO2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: FBX2_HUMAN, Q9UK22
    Pathway: Protein modification; protein ubiquitination


    FBXO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for FBXO2 (Q9UK223 ENSP000003462404) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=4 STRING: ENSP00000231487
    BACE1P568173, ENSP000003185854I2D: score=2 STRING: ENSP00000318585
    VCPP550723, ENSP000003517774I2D: score=2 STRING: ENSP00000351777
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    RBX1P628773, ENSP000002162254I2D: score=1 STRING: ENSP00000216225
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10531035
    GO:0006508proteolysis TAS10531035
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0006516glycoprotein catabolic process ISS--
    GO:0016567protein ubiquitination ISS--


    FBXO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FBXO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO2
    Search CenterWatch for drugs/clinical trials and news about FBXO2 / FBX2 

    Transcripts
    for FBXO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FBXO2 gene: 
    NM_012168.5  

    Unigene Cluster for FBXO2:

    F-box protein 2
    Hs.132753  [show with all ESTs]
    Unigene Representative Sequence: NM_012168
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354287(uc009vnb.1 uc001asj.3 uc009vna.3) ENST00000471501
    ENST00000466919 ENST00000465901 ENST00000475961

    miRNA
    Products:             		 OriGene 3'-UTR Clone: FBXO2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXO2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO2:
    hsa-miR-1207-3p hsa-miR-3667-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FBXO2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO2 (see all 7)
    OriGene shRNA RFP: FBXO2
    OriGene siRNA: FBXO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO2 (NM_033624)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO2

    Additional cDNA sequence: 

    AF174594.1 AF187318.1 AK308531.1 AK313019.1 BC014957.1 BC025233.1 BC096747.1 BC127894.1 
    CR542110.1 

    5 DOTS entries:

    DT.453903  DT.97790134  DT.91707486  DT.95285528  DT.95325489 

    24/92 AceView cDNA sequences (see all 92):

    AW135504 AW341533 BI966703 BM699742 AW160505 AI767575 BI763235 BQ953154 
    BM142251 AI928563 BE672326 BC025233 CK819341 BG829900 AW779941 CF129959 
    AF187318 BI962854 BV167675 C00398 AA063432 AI952839 AW772633 BE464909 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:              -     -                                   -                     
    SP2:                                            -           -                     
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for FBXO2

    Expression
    for FBXO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGGACGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FBXO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

    See FBXO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO2

    SOURCE GeneReport for Unigene cluster: Hs.132753
        SABiosciences Expression via Pathway-Focused PCR Array including FBXO2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXO2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO2

    Orthologs
    for FBXO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FBXO2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FBXO21 F-box protein 2 69.5(n)
    70.04(a)    		   419495  XM_417650.1  XP_417650.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FBXO26
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343881.1(106975-113273)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1750881 zgc:175088 60.12(n)
    57.23(a)    		   559776  NM_001113798.1  NP_001107270.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 27(a)
    		 1 → many
    		 GroupUn.464(7518-8665)


    ENSEMBL Gene Tree for FBXO2 (if available)
    TreeFam Gene Tree for FBXO2 (if available) 

    Paralogs
    for FBXO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO2 gene
    FBXO62  FBXO272  FBXO442  NCCRP12  
    4 SIMAP similar genes for FBXO2 using alignment to 1 protein entry:     FBX2_HUMAN:
    FBXO44    FBXO6    FBXO27    FBXO17

    FBXO2 for paralogs           About GeneDecksing



    Genomic Variants
    for FBXO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/165 NCBI SNPs in FBXO2 are shown (see all 165)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1168122251,2
    		C,F,--11707990(+) GCCTCT/CACCCT 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1391362741,2
    		--11708377(+) TATGCC/TGGGGG 1 -- ds50010--------
    rs1899423301,2
    		--11708425(+) TTTATC/GCATTT 1 -- ut310--------
    rs1150077071,2
    		C,F,--11708537(+) CTCACG/ACCCTC 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs751799871,2
    		F,--11708678(+) CTATGG/AACTAA 1 -- ut311Minor allele frequency- A:0.03EA 120
    rs10555471,2
    		C,F,A,H,--11708736(-) CCTCCA/GCTCTC 1 -- ut31 ese323Minor allele frequency- G:0.45EA MN NS NA WA EU 4930
    rs1815871191,2
    		C,--11708747(+) CAGGGA/TCGCTC 1 -- ut310--------
    rs1412665991,2
    		C,F,--11708856(+) ACGCCC/TGGCCC 2 P syn12Minor allele frequency- T:0.00NA EU 5769
    rs1114561011,2
    		C,F,--11708916(+) GCCTCG/AGAGGT 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs2017729331,2
    		--11708920(+) CGGAGA/GTCCTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FBXO2 (11708424 - 11715842 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FBXO2
         1 CNV: 48094

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    Disorders / Diseases
    for FBXO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FBXO2 for disorders           About GeneDecksing

    OMIM gene information: 607112    OMIM disorders: --

    8 diseases for FBXO2:    About MalaCards
    benign paroxysmal positional nystagmus    herpes simplex    nystagmus    meniere's disease
    menieres disease    neuronitis    amyloidosis    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for FBXO2:
    Benign paroxysmal positional nystagmus     Meniere's disease

    1 Novoseek disease relationship for FBXO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 40.5 2 15010529 (1)


    Export disorders for FBXO2 gene to outside databases

    Publications
    for FBXO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO2 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with FBXO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 9 Glenn K.A.... Paulson H.L. (2008)
    6. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 9 Ilyin G.P....Guguen-Guillouzo C. (2002)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-pro teasome pathway and macroautophagy. (PubMed id 22917612)1 Gordon K.L....Gonzalez-Alegre P. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1 Gorbea C.... Rechsteiner M. (2010)

    External Searches for FBXO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FBXO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26232 HGNC: 13581 AceView: FBXO2 Ensembl:ENSG00000116661 euGenes: HUgn26232
    ECgene: FBXO2 Kegg: 26232 H-InvDB: FBXO2

    Other Databases showing FBXO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FBXO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FBXO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FBXO2 gene:
    Search GeneIP for patents involving FBXO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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