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FBXO18 Gene

protein-coding   GIFtS: 51
GCID: GC10P005931

F-Box Protein, Helicase, 18

(Previous name: F-box only protein 18)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein, Helicase, 181 2     FBX183 5
FBH12 3 5     Fbx182
F-Box Only Protein 181 2     F-Box Only Protein, Helicase, 182
F-Box DNA Helicase 12 3     EC 3.6.4.123

External Ids:    HGNC: 136201   Entrez Gene: 848932   Ensembl: ENSG000001344527   OMIM: 6072225   UniProtKB: Q8NFZ03   

Export aliases for FBXO18 gene to outside databases

Previous GC identifers: GC10P005876 GC10P006082 GC10P005936 GC10P005972


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO18 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs,
and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants
encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO18 Gene:
FBXO18 (F-box protein, helicase, 18) is a protein-coding gene. GO annotations related to this gene include ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot: FBX18_HUMAN, Q8NFZ0
Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO18 gene promoter:
         SRY   Sox9   SEF-1 (1)   c-Myb   CUTL1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FBXO18 promoter sequence
   Search Chromatin IP Primers for FBXO18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

FBXO18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P005931:  view genomic region     (about GC identifiers)

Start:
5,931,535 bp from pter      End:
5,979,556 bp from pter
Size:
48,022 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBX18_HUMAN, Q8NFZ0 (See protein sequence)
Recommended Name: F-box only protein 18  
Size: 1043 amino acids; 117686 Da
Subunit: Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1
Sequence caution: Sequence=AAM73631.1; Type=Erroneous initiation; Sequence=BAB55073.1; Type=Erroneous initiation;
Sequence=BAB55154.1; Type=Erroneous initiation;
Secondary accessions: Q5JVB0 Q5JVB1 Q7Z4Q6 Q7Z4R0 Q8N1P5 Q8N586 Q96E82 Q96K67 Q96SW7 Q9UFB2
Alternative splicing: 2 isoforms:  Q8NFZ0-1   Q8NFZ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO18: NX_Q8NFZ0

Explore proteomics data for FBXO18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys301
  • Modification sites at PhosphoSitePlus

  • See FBXO18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001245381.1  NP_001245382.1  NP_116196.3  NP_835363.1  

    ENSEMBL proteins: 
     ENSP00000355415   ENSP00000369335   ENSP00000380439  

    FBXO18 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO18

     
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    antibodies-online peptides for FBXO18

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    antibodies-online antibodies for FBXO18 (29 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    5 InterPro protein domains:
     IPR014016 UvrD-like_ATP-bd
     IPR014017 DNA_helicase_UvrD-like_C
     IPR000212 DNA_helicase_UvrD/REP
     IPR001810 F-box_dom
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8NFZ0

    ProtoNet protein and cluster: Q8NFZ0

    UniProtKB/Swiss-Prot: FBX18_HUMAN, Q8NFZ0
    Similarity: Belongs to the helicase family. UvrD subfamily
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX18_HUMAN, Q8NFZ0
    Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction
    Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
    degradation
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with FBXO18           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for FBXO18:
     Decreased p24 protein expressi  Decreased viability with pacli  Increased G2M DNA content  Increased cell death HMECs cel 
     Increased cell size 

         1 MGI phenotypic allele for Fbxo18 (no phenotypes)

    Find genes that share phenotypes with FBXO18           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FBXO18

    miRNA
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    miRTarBase miRNAs that target FBXO18:
    hsa-mir-124-3p (MIRT022343), hsa-mir-877-3p (MIRT037140)

    Block miRNA regulation of human, mouse, rat FBXO18 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate FBXO18:
    hsa-miR-374a* hsa-miR-548t hsa-miR-892b hsa-miR-539 hsa-miR-561 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidFBXO18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO18

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX18_HUMAN, Q8NFZ0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with FBXO18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO18: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO18 (Q8NFZ01, 3 ENSP000003693354) via UniProtKB, MINT, STRING, and/or I2D (see all 356)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIM2Q9P1W93, ENSP000003656924I2D: score=3 STRING: ENSP00000365692
    RPL13AP404293, ENSP000003757304I2D: score=3 STRING: ENSP00000375730
    RBX1P628773, ENSP000002162254I2D: score=2 STRING: ENSP00000216225
    CUL1Q136163, ENSP000003268044I2D: score=3 STRING: ENSP00000326804
    SKP1P632083, ENSP000002314874I2D: score=4 STRING: ENSP00000231487
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO18 (FBX18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO18 gene (4 alternative transcripts): 
    NM_001258452.1  NM_001258453.1  NM_032807.4  NM_178150.2  

    Unigene Cluster for FBXO18:

    F-box protein, helicase, 18
    Hs.498543  [show with all ESTs]
    Unigene Representative Sequence: AK226128
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000362091(uc001iis.3 uc009xig.3) ENST00000470089 ENST00000462507
    ENST00000379999(uc001iit.3) ENST00000469009 ENST00000494526 ENST00000460453
    ENST00000489042 ENST00000475867 ENST00000461504 ENST00000485290 ENST00000496013
    ENST00000479433 ENST00000470353 ENST00000481029 ENST00000397269(uc001iir.3)

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate FBXO18:
    hsa-miR-374a* hsa-miR-548t hsa-miR-892b hsa-miR-539 hsa-miR-561 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidFBXO18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO18
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO18 (NM_178150)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO18
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO18
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO18
      QuantiFast Probe-based Assays in human, mouse, rat FBXO18

    Additional mRNA sequence: 

    AF380349.1 AF454502.1 AF456237.1 AK027381.1 AK095343.1 AK122753.1 AK226128.1 AK315173.1 
    AL133069.1 BC006430.1 BC012762.2 BC020266.1 BC032674.1 BC080629.1 BC110884.1 BC113375.1 
    BC113377.1 

    24 DOTS entries:

    DT.418322  DT.100821871  DT.100716151  DT.100821870  DT.100030417  DT.97795630  DT.92435193  DT.92435199 
    DT.121218254  DT.100735559  DT.91880016  DT.97807358  DT.40188833  DT.92435203  DT.95306135  DT.95342462 
    DT.100821873  DT.121218252  DT.121218262  DT.99963504  DT.100030419  DT.100821869  DT.121218222  DT.121218324 

    Selected AceView cDNA sequences (see all 350):

    AK027381 AF456237 AA430193 C04842 AA425736 AA489961 CD518455 AI955677 
    BC080629 AI884325 AI743934 BC020266 AI435517 BC006430 AA987283 AL044721 
    AA350410 NM_178150 BQ879942 CA976039 AW339627 CR596857 AA321866 AI887140 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXO18 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                                                        -                                                           -                       -               
    SP2:                    -     -     -     -                 -                                                           -                       -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -           -                       -                                                                                                   

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28
    SP1:                                            -           -     -                       -                           
    SP2:                                            -           -     -                       -                           
    SP3:                    -                       -                                                                     
    SP4:                                            -                 -                       -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for FBXO18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FBXO18 Expression
    About this image


    FBXO18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FBXO18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498543
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXO18: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO18
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    QuantiFast Probe-based Assays in human, mouse, rat FBXO18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO18 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo181 , 5 F-box protein 181, 5 87.33(n)1
    90.47(a)1
      2 (9.01 cM)5
    507551  NM_015792.11  NP_056607.11 
     117425735 
    chicken
    (Gallus gallus)
    Aves FBXO181 F-box protein, helicase, 18 60.51(n)
    54.18(a)
      416687  NM_001080210.1  NP_001073679.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO186
    F-box protein, helicase, 18
    47(a)
    1 ↔ 1
    5(3834649-3866717)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.153382 Transcribed sequence with weak similarity to protein more 74.69(n)    AL890140.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo181 F-box protein, helicase, 18 56(n)
    50.15(a)
      567995  NM_001045149.1  NP_001038614.1 


    ENSEMBL Gene Tree for FBXO18 (if available)
    TreeFam Gene Tree for FBXO18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO18 (see all 1213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007965231,2
    C--5934038(+) TTTCTA/GGNNNN 3 -- int10--------
    rs339481261,2
    C--5934039(+) TCTGG-/AGCAAA 3 -- int10--------
    rs2020487481,2
    C--5934039(+) TTCTGA/GGCAAA 3 -- int10--------
    rs754719741,2
    C,F--5934110(+) TCTTGC/TTGTTT 3 -- int11Minor allele frequency- T:0.06WA 118
    rs790442231,2
    C,F--5934150(+) AGACTT/ATTGGA 3 -- int11Minor allele frequency- A:0.02NA 120
    rs1379309981,2
    --5934294(+) TTGACA/CGGTTT 3 -- int10--------
    rs1821441431,2
    --5934367(+) TTTGTG/TGACAT 4 -- us2k1 int10--------
    rs1866496691,2
    --5934582(+) GTATTC/TCACAG 4 -- us2k1 int10--------
    rs6858521,2
    C,F,A--5934617(-) CCTAGT/CTTTAA 4 -- us2k1 int18Minor allele frequency- C:0.44NA WA EA 370
    rs38474161,2
    C,F--5934646(-) TCCCCC/TGGAGT 4 -- us2k1 int1 trp31Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for FBXO18 (5931535 - 5979556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FBXO18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007377CNV Insertion20482838
    esv1168062CNV Insertion17803354
    dgv1e49CNV Loss18971310
    esv5719CNV Loss19470904
    nsv831775CNV Loss17160897
    nsv825229CNV Gain20364138

    Human Gene Mutation Database (HGMD): FBXO18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO18
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607222    OMIM disorders: --


    Find genes that share disorders with FBXO18           About GenesLikeMe

    Genetic Association Database (GAD): FBXO18
    Human Genome Epidemiology (HuGE) Navigator: FBXO18 (2 documents)

    Export disorders for FBXO18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO18 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with FBXO18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel human DNA helicase hFBH1 is an F-box protein. (PubMed id 11956208)1, 2, 3 Kim J.... Seo Y.-S. (J. Biol. Chem. 2002)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    7. FBH1 protects melanocytes from transformation and is deregulated in melanomas. (PubMed id 23466708)1 Jeong Y.T....Pagano M. (Cell Cycle 2013)
    8. FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress. (PubMed id 23361013)1 Fugger K....rensen C.S. (Nat Commun 2013)
    9. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. (PubMed id 23319600)1 Jeong Y.T....Pagano M. (J. Cell Biol. 2013)
    10. Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase. (PubMed id 23393192)1 Masuda-Ozawa T....Spies M. (Nucleic Acids Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84893 HGNC: 13620 AceView: FBXO18 Ensembl:ENSG00000134452 euGenes: HUgn84893
    ECgene: FBXO18 H-InvDB: FBXO18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FBXO18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO18 gene:
    Search GeneIP for patents involving FBXO18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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