Aliases for FBXO18 Gene
External Ids for FBXO18 Gene
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXO18 Gene
FBXO18 (F-Box Protein, Helicase, 18) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent DNA helicase activity.
UniProtKB/Swiss-Prot for FBXO18 Gene
DNA-dependent ATPase. Unwinds double-stranded DNA in a 3 to 5 direction.
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.