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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO18 Gene

protein-coding   GIFtS: 50
GCID: GC10P005931

F-Box Protein, Helicase, 18

(Previous name: F-box only protein 18)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein, Helicase, 181 2     FBX183 5
FBH12 3 5     Fbx182
F-Box Only Protein 181 2     F-Box Only Protein, Helicase, 182
F-Box DNA Helicase 12 3     EC 3.6.4.123

External Ids:    HGNC: 136201   Entrez Gene: 848932   Ensembl: ENSG000001344527   OMIM: 6072225   UniProtKB: Q8NFZ03   

Export aliases for FBXO18 gene to outside databases

Previous GC identifers: GC10P005876 GC10P006082 GC10P005936 GC10P005972


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO18 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs,
and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants
encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXO18 Gene: 
FBXO18 (F-box protein, helicase, 18) is a protein-coding gene. Diseases associated with FBXO18 include alzheimer's disease. GO annotations related to this gene include ATP-dependent DNA helicase activity and ATP binding.

UniProtKB/Swiss-Prot: FBX18_HUMAN, Q8NFZ0
Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO18 gene promoter:
         SRY   Sox9   SEF-1 (1)   c-Myb   CUTL1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): FBXO18 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

FBXO18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P005931:  view genomic region     (about GC identifiers)

Start:
5,931,535 bp from pter      End:
5,979,556 bp from pter
Size:
48,022 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX18_HUMAN, Q8NFZ0 (See protein sequence)
Recommended Name: F-box only protein 18  
Size: 1043 amino acids; 117686 Da
Subunit: Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAM73631.1; Type=Erroneous initiation; Sequence=BAB55073.1; Type=Erroneous initiation;
Sequence=BAB55154.1; Type=Erroneous initiation;
Secondary accessions: Q5JVB0 Q5JVB1 Q7Z4Q6 Q7Z4R0 Q8N1P5 Q8N586 Q96E82 Q96K67 Q96SW7 Q9UFB2
Alternative splicing: 2 isoforms:  Q8NFZ0-1   Q8NFZ0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO18: NX_Q8NFZ0

Explore proteomics data for FBXO18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFZ0

  • FBXO18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO18 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001245381.1  NP_001245382.1  NP_116196.3  NP_835363.1  

    ENSEMBL proteins: 
     ENSP00000355415   ENSP00000369335   ENSP00000369330   ENSP00000380439  

    Human Recombinant Protein Products for FBXO18: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO18 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    FBXO18 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    5 InterPro protein domains:
     IPR014016 UvrD-like_ATP-bd
     IPR014017 DNA_helicase_UvrD-like_C
     IPR000212 DNA_helicase_UvrD/REP
     IPR001810 F-box_dom_cyclin-like
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8NFZ0

    ProtoNet protein and cluster: Q8NFZ0

    UniProtKB/Swiss-Prot: FBX18_HUMAN, Q8NFZ0
    Similarity: Belongs to the helicase family. UvrD subfamily
    Similarity: Contains 1 F-box domain


    FBXO18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX18_HUMAN, Q8NFZ0
    Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction
    Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
    degradation
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    FBXO18 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for FBXO18:
     Decreased p24 protein expressi  Decreased viability with pacli  Increased G2M DNA content  Increased cell death HMECs cel 
     Increased cell size 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO18 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for FBXO18 (Q8NFZ03 ENSP000003693354) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136163, ENSP000003268044I2D: score=3 STRING: ENSP00000326804
    RBX1P628773, ENSP000002162254I2D: score=2 STRING: ENSP00000216225
    SKP1P632083, ENSP000002314874I2D: score=4 STRING: ENSP00000231487
    PIM2Q9P1W93, ENSP000003656924I2D: score=3 STRING: ENSP00000365692
    RPL13AP404293, ENSP000003757304I2D: score=3 STRING: ENSP00000375730
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO18 (FBX18)

    Search CenterWatch for drugs/clinical trials and news about FBXO18 / FBX18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO18 gene (4 alternative transcripts): 
    NM_001258452.1  NM_001258453.1  NM_032807.4  NM_178150.2  

    Unigene Cluster for FBXO18:

    F-box protein, helicase, 18
    Hs.498543  [show with all ESTs]
    Unigene Representative Sequence: AK226128
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000362091(uc001iis.3 uc009xig.3) ENST00000470089 ENST00000462507
    ENST00000379999(uc001iit.3) ENST00000469009 ENST00000494526 ENST00000379994
    ENST00000460453 ENST00000489042 ENST00000475867 ENST00000461504 ENST00000485290
    ENST00000496013 ENST00000479433 ENST00000470353 ENST00000481029 ENST00000397269(uc001iir.3)


    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO18:
    hsa-miR-374a* hsa-miR-548t hsa-miR-892b hsa-miR-539 hsa-miR-561 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidFBXO18 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF380349.1 AF454502.1 AF456237.1 AK027381.1 AK095343.1 AK122753.1 AK226128.1 AK315173.1 
    AL133069.1 BC006430.1 BC012762.2 BC020266.1 BC032674.1 BC080629.1 BC110884.1 BC113375.1 
    BC113377.1 

    24 DOTS entries:

    DT.418322  DT.100821871  DT.100716151  DT.100821870  DT.100030417  DT.97795630  DT.92435193  DT.92435199 
    DT.121218254  DT.100735559  DT.91880016  DT.97807358  DT.40188833  DT.92435203  DT.95306135  DT.95342462 
    DT.100821873  DT.121218252  DT.121218262  DT.99963504  DT.100030419  DT.100821869  DT.121218222  DT.121218324 

    24/350 AceView cDNA sequences (see all 350):

    AI955677 AI435517 AA430193 AI244171 AA350410 AI890562 CR596857 BQ129349 
    BM699811 CD513292 BG575794 BM673880 BQ073711 BU630100 AA613121 AI435127 
    BG682347 AF456237 AI884325 BQ932104 BQ614300 CA976039 AK027381 AI273889 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO18 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                                                        -                                                           -                       -               
    SP2:                    -     -     -     -                 -                                                           -                       -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -           -                       -                                                                                                   

    ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28
    SP1:                                            -           -     -                       -                           
    SP2:                                            -           -     -                       -                           
    SP3:                    -                       -                                                                     
    SP4:                                            -                 -                       -                           
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for FBXO18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO18 expression in normal human tissues (normalized intensities)      FBXO18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FBXO18 Expression
    About this image


    FBXO18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See FBXO18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO18

    SOURCE GeneReport for Unigene cluster: Hs.498543
        SABiosciences Expression via Pathway-Focused PCR Array including FBXO18: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO18 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo181 , 5 F-box protein 181, 5 87.33(n)1
    90.47(a)1
      2 (9.01 cM)5
    507551  NM_015792.11  NP_056607.11 
     117425735 
    chicken
    (Gallus gallus)
    Aves FBXO181 F-box protein, helicase, 18 60.2(n)
    53.66(a)
      416687  NM_001080210.1  NP_001073679.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO186
    F-box protein, helicase, 18
    46(a)
    1 ↔ 1
    5(3834649-3866717)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.153382 Transcribed sequence with weak similarity to protein more 74.69(n)    AL890140.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo181 F-box protein, helicase, 18 55.92(n)
    50.26(a)
      567995  NM_001045149.1  NP_001038614.1 


    ENSEMBL Gene Tree for FBXO18 (if available)
    TreeFam Gene Tree for FBXO18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1213 SNPs in FBXO18 are shown (see all 1213)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007965231,2
    C--5934038(+) TTTCTA/GGNNNN 3 -- int10--------
    rs339481261,2
    C--5934039(+) TCTGG-/AGCAAA 3 -- int10--------
    rs2020487481,2
    C--5934039(+) TTCTGA/GGCAAA 3 -- int10--------
    rs754719741,2
    C,F--5934110(+) TCTTGC/TTGTTT 3 -- int11Minor allele frequency- T:0.06WA 118
    rs790442231,2
    C,F--5934150(+) AGACTT/ATTGGA 3 -- int11Minor allele frequency- A:0.02NA 120
    rs1379309981,2
    --5934294(+) TTGACA/CGGTTT 3 -- int10--------
    rs1821441431,2
    --5934367(+) TTTGTG/TGACAT 4 -- us2k1 int10--------
    rs1866496691,2
    --5934582(+) GTATTC/TCACAG 4 -- us2k1 int10--------
    rs6858521,2
    C,F,A--5934617(-) CCTAGT/CTTTAA 4 -- us2k1 int18Minor allele frequency- C:0.44NA WA EA 370
    rs38474161,2
    C,F--5934646(-) TCCCCC/TGGAGT 4 -- us2k1 int1 trp31Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for FBXO18 (5931535 - 5979556 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FBXO18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007377CNV Insertion20482838
    esv1168062CNV Insertion17803354
    dgv1e49CNV Loss18971310
    esv5719CNV Loss19470904
    nsv831775CNV Loss17160897
    nsv825229CNV Gain20364138


    Human Gene Mutation Database (HGMD): FBXO18
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO18
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607222    OMIM disorders: --

    2 diseases for FBXO18:    About MalaCards
    alzheimer's disease    


    FBXO18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): FBXO18
    Human Genome Epidemiology (HuGE) Navigator: FBXO18 (2 documents)

    Export disorders for FBXO18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO18 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with FBXO18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel human DNA helicase hFBH1 is an F-box protein. (PubMed id 11956208)1, 2, 3 Kim J.... Seo Y.-S. (2002)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T....Harper J.W. (1999)
    7. FBH1 co-operates with MUS81 in inducing DNA double-str and breaks and cell death following replication stress. (PubMed id 23361013)1 Fugger K....Sorensen C.S. (2013)
    8. FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. (PubMed id 23319600)1 Jeong Y.T....Pagano M. (2013)
    9. Single-molecule sorting reveals how ubiquitylation aff ects substrate recognition and activities of FBH1 helicase. (PubMed id 23393192)1 Masuda-Ozawa T....Spies M. (2013)
    10. The helicase FBH1 is tightly regulated by PCNA via CRL 4(Cdt2)-mediated proteolysis in human cells. (PubMed id 23677613)1 Bacquin A....Kannouche P.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84893 HGNC: 13620 AceView: FBXO18 Ensembl:ENSG00000134452 euGenes: HUgn84893
    ECgene: FBXO18 H-InvDB: FBXO18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FBXO18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO18 gene:
    Search GeneIP for patents involving FBXO18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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