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Aliases for FBXO18 Gene

Aliases for FBXO18 Gene

  • F-Box Protein, Helicase, 18 2 3
  • Fbx18 3 4 6
  • FBH1 3 4 6
  • F-Box Only Protein 18 2 3
  • F-Box DNA Helicase 1 3 4
  • F-Box Only Protein, Helicase, 18 3
  • EC 3.6.4.12 4

External Ids for FBXO18 Gene

Previous GeneCards Identifiers for FBXO18 Gene

  • GC10P005876
  • GC10P006082
  • GC10P005936
  • GC10P005972

Summaries for FBXO18 Gene

Entrez Gene Summary for FBXO18 Gene

  • This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXO18 Gene

FBXO18 (F-Box Protein, Helicase, 18) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for FBXO18 Gene

  • DNA-dependent ATPase. Unwinds double-stranded DNA in a 3 to 5 direction.

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO18 Gene

Genomics for FBXO18 Gene

Regulatory Elements for FBXO18 Gene

Genomic Location for FBXO18 Gene

Start:
5,889,572 bp from pter
End:
5,937,595 bp from pter
Size:
48,024 bases
Orientation:
Plus strand

Genomic View for FBXO18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO18 Gene

Proteins for FBXO18 Gene

  • Protein details for FBXO18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFZ0-FBX18_HUMAN
    Recommended name:
    F-box only protein 18
    Protein Accession:
    Q8NFZ0
    Secondary Accessions:
    • Q5JVB0
    • Q5JVB1
    • Q7Z4Q6
    • Q7Z4R0
    • Q8N1P5
    • Q8N586
    • Q96E82
    • Q96K67
    • Q96SW7
    • Q9UFB2

    Protein attributes for FBXO18 Gene

    Size:
    1043 amino acids
    Molecular mass:
    117686 Da
    Quaternary structure:
    • Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1.
    SequenceCaution:
    • Sequence=AAM73631.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55154.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO18 Gene

Proteomics data for FBXO18 Gene at MOPED

Post-translational modifications for FBXO18 Gene

  • Ubiquitination at Lys301
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO18 Gene

No data available for DME Specific Peptides for FBXO18 Gene

Domains for FBXO18 Gene

Gene Families for FBXO18 Gene

HGNC:
  • FBXO :F-boxes / "other"

Graphical View of Domain Structure for InterPro Entry

Q8NFZ0

UniProtKB/Swiss-Prot:

FBX18_HUMAN :
  • Q8NFZ0
Domain:
  • Contains 1 F-box domain.
Family:
  • Belongs to the helicase family. UvrD subfamily.
genes like me logo Genes that share domains with FBXO18: view

Function for FBXO18 Gene

Molecular function for FBXO18 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3 to 5 direction.
UniProtKB/Swiss-Prot Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Enzyme Numbers (IUBMB) for FBXO18 Gene

Gene Ontology (GO) - Molecular Function for FBXO18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004003 ATP-dependent DNA helicase activity IEA --
GO:0005515 protein binding IPI 23954233
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with FBXO18: view
genes like me logo Genes that share phenotypes with FBXO18: view

Animal Model Products

CRISPR Products

miRNA for FBXO18 Gene

miRTarBase miRNAs that target FBXO18

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO18 Gene

Localization for FBXO18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO18 Gene COMPARTMENTS Subcellular localization image for FBXO18 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBXO18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FBXO18: view

Pathways for FBXO18 Gene

SuperPathways for FBXO18 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FBXO18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic IMP 23361013
GO:0001934 positive regulation of protein phosphorylation IMP 23361013
GO:0032508 DNA duplex unwinding IEA --
GO:0072429 response to intra-S DNA damage checkpoint signaling IMP 23361013
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP 23361013
genes like me logo Genes that share ontologies with FBXO18: view

No data available for Pathways by source for FBXO18 Gene

Transcripts for FBXO18 Gene

Unigene Clusters for FBXO18 Gene

F-box protein, helicase, 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXO18

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FBXO18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: - - -
SP6: - - - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for FBXO18 Gene

GeneLoc Exon Structure for
FBXO18
ECgene alternative splicing isoforms for
FBXO18

Expression for FBXO18 Gene

mRNA expression in normal human tissues for FBXO18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO18 Gene

SOURCE GeneReport for Unigene cluster for FBXO18 Gene Hs.498543

genes like me logo Genes that share expressions with FBXO18: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXO18 Gene

Orthologs for FBXO18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO18 35
  • 99.17 (n)
  • 98.89 (a)
FBXO18 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO18 35
  • 84.9 (n)
  • 89.25 (a)
FBXO18 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO18 35
  • 87.92 (n)
  • 92.52 (a)
FBXO18 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo18 35
  • 87.33 (n)
  • 90.47 (a)
Fbxo18 16
Fbxo18 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO18 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO18 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo18 35
  • 87.01 (n)
  • 90.28 (a)
chicken
(Gallus gallus)
Aves FBXO18 35
  • 60.51 (n)
  • 54.18 (a)
FBXO18 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO18 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo18 35
  • 59.24 (n)
  • 55.75 (a)
Str.15338 35
zebrafish
(Danio rerio)
Actinopterygii fbxo18 35
  • 56 (n)
  • 50.15 (a)
fbxo18 36
  • 47 (a)
OneToOne
Species with no ortholog for FBXO18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO18 Gene

ENSEMBL:
Gene Tree for FBXO18 (if available)
TreeFam:
Gene Tree for FBXO18 (if available)

Paralogs for FBXO18 Gene

No data available for Paralogs for FBXO18 Gene

Variants for FBXO18 Gene

Sequence variations from dbSNP and Humsavar for FBXO18 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs588742 -- 5,899,329(-) AAAAA(C/T)AAAAC intron-variant
rs591510 -- 5,899,990(-) TTCTG(C/T)AATGT intron-variant
rs591878 -- 5,893,474(-) GATGA(A/G)GAATG intron-variant, upstream-variant-2KB
rs593026 -- 5,919,135(+) tgctg(A/C)atttt intron-variant
rs593610 -- 5,909,600(-) AATCC(C/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO18 Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV Loss 18971310
nsv831775 CNV Loss 17160897
nsv825229 CNV Gain 20364138
esv5719 CNV Loss 19470904
esv1007377 CNV Insertion 20482838
esv1168062 CNV Insertion 17803354

Relevant External Links for FBXO18 Gene

HapMap Linkage Disequilibrium report
FBXO18
Human Gene Mutation Database (HGMD)
FBXO18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO18 Gene

Disorders for FBXO18 Gene

Relevant External Links for FBXO18

Genetic Association Database (GAD)
FBXO18
Human Genome Epidemiology (HuGE) Navigator
FBXO18
genes like me logo Genes that share disorders with FBXO18: view

No data available for UniProtKB/Swiss-Prot for FBXO18 Gene

Publications for FBXO18 Gene

  1. The novel human DNA helicase hFBH1 is an F-box protein. (PMID: 11956208) Kim J. … Seo Y.-S. (J. Biol. Chem. 2002) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for FBXO18 Gene

Sources for FBXO18 Gene

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