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Aliases for FBXO17 Gene

Aliases for FBXO17 Gene

  • F-Box Protein 17 2 3 5
  • F-Box Only Protein 26 2 3 4
  • FBXO26 3 4
  • Fbx17 3 4
  • FBX26 3 4
  • FBG4 3 4
  • F-Box Only Protein 17 2
  • F-Box Protein FBG4 3

External Ids for FBXO17 Gene

Previous HGNC Symbols for FBXO17 Gene

  • FBXO26

Previous GeneCards Identifiers for FBXO17 Gene

  • GC19M044124
  • GC19M044125
  • GC19M039406
  • GC19M039432

Summaries for FBXO17 Gene

Entrez Gene Summary for FBXO17 Gene

  • This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXO17 Gene

FBXO17 (F-Box Protein 17) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO27.

UniProtKB/Swiss-Prot for FBXO17 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO17 Gene

Genomics for FBXO17 Gene

Regulatory Elements for FBXO17 Gene

Promoters for FBXO17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO17 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO17 Gene

38,941,401 bp from pter
38,975,910 bp from pter
34,510 bases
Minus strand

Genomic View for FBXO17 Gene

Genes around FBXO17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO17 Gene

Proteins for FBXO17 Gene

  • Protein details for FBXO17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 17
    Protein Accession:
    Secondary Accessions:
    • Q96LQ4

    Protein attributes for FBXO17 Gene

    278 amino acids
    Molecular mass:
    31479 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
    • Sequence=BAB71616.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO17 Gene

Proteomics data for FBXO17 Gene at MOPED

Post-translational modifications for FBXO17 Gene

No Post-translational modifications

Other Protein References for FBXO17 Gene

Antibody Products

No data available for DME Specific Peptides for FBXO17 Gene

Domains & Families for FBXO17 Gene

Gene Families for FBXO17 Gene

Protein Domains for FBXO17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
  • Contains 1 FBA (F-box associated) domain.
genes like me logo Genes that share domains with FBXO17: view

Function for FBXO17 Gene

Molecular function for FBXO17 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

Gene Ontology (GO) - Molecular Function for FBXO17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18203720
genes like me logo Genes that share ontologies with FBXO17: view
genes like me logo Genes that share phenotypes with FBXO17: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO17 Gene

Localization for FBXO17 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FBXO17 Gene

Pathways & Interactions for FBXO17 Gene

genes like me logo Genes that share pathways with FBXO17: view

Gene Ontology (GO) - Biological Process for FBXO17 Gene


No data available for SIGNOR curated interactions for FBXO17 Gene

Drugs & Compounds for FBXO17 Gene

No Compound Related Data Available

Transcripts for FBXO17 Gene

Unigene Clusters for FBXO17 Gene

F-box protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO17 Gene

No ASD Table

Relevant External Links for FBXO17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO17 Gene

mRNA expression in normal human tissues for FBXO17 Gene

Protein differential expression in normal tissues from HIPED for FBXO17 Gene

This gene is overexpressed in Vitreous humor (24.0), Ovary (22.2), and Fetal testis (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO17 Gene

SOURCE GeneReport for Unigene cluster for FBXO17 Gene Hs.531770

mRNA Expression by UniProt/SwissProt for FBXO17 Gene

Tissue specificity: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
genes like me logo Genes that share expression patterns with FBXO17: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for FBXO17 Gene

Orthologs for FBXO17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO17 35
  • 90.89 (n)
  • 93.53 (a)
FBXO17 36
  • 91 (a)
(Canis familiaris)
Mammalia FBXO17 35
  • 87.85 (n)
  • 90.22 (a)
FBXO17 36
  • 90 (a)
(Mus musculus)
Mammalia Fbxo17 35
  • 83.15 (n)
  • 87 (a)
Fbxo17 16
Fbxo17 36
  • 84 (a)
(Pan troglodytes)
Mammalia FBXO27 35
  • 85.58 (n)
  • 82.18 (a)
(Rattus norvegicus)
Mammalia Fbxo17 35
  • 82.85 (n)
  • 83.09 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
-- 36
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for FBXO17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO17 Gene

Gene Tree for FBXO17 (if available)
Gene Tree for FBXO17 (if available)

Paralogs for FBXO17 Gene

Paralogs for FBXO17 Gene

(4) SIMAP similar genes for FBXO17 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FBXO17: view

Variants for FBXO17 Gene

Sequence variations from dbSNP and Humsavar for FBXO17 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs575 -- 38,942,143(+) CAGCA(C/T)GATGG nc-transcript-variant, utr-variant-3-prime
rs535171 -- 38,975,754(-) GCCCC(C/G)GGCGC nc-transcript-variant, utr-variant-5-prime
rs934421 -- 38,968,722(+) AAGCA(A/G)TAAAA intron-variant
rs1134180 -- 38,941,496(-) cttat(C/T)actgg nc-transcript-variant, utr-variant-3-prime
rs1865047 -- 38,946,894(+) AAGTG(C/T)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO17 Gene

Variant ID Type Subtype PubMed ID
esv2718541 CNV Deletion 23290073
esv2718542 CNV Deletion 23290073
esv2718543 CNV Deletion 23290073

Variation tolerance for FBXO17 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO17 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO17 Gene

Disorders for FBXO17 Gene

Relevant External Links for FBXO17

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO17 Gene

Publications for FBXO17 Gene

  1. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 23 67
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for FBXO17 Gene

Sources for FBXO17 Gene

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