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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO17 Gene

protein-coding   GIFtS: 51
GCID: GC19M039406

F-box protein 17

(Previous name: F-box only protein 17 )
(Previous symbol: FBXO26)
 Explore 9 diseases affiliated with
FBXO17 via our new
 Human Malady Compendium 
Biological research products
for FBXO17
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
F-Box Protein 171 2     F-Box Only Protein 262 3
FBG41 2 3 5     FBX173 5
FBXO261 2 3     FLJ117981
FBX262 3 5     FLJ252051
Fbx171 2     MGC93791
F-Box Only Protein 171 2     F-Box Protein FBG42

External Ids:    HGNC: 187541   Entrez Gene: 1152902   Ensembl: ENSG000001048357   OMIM: 6090945   UniProtKB: Q96EF63   

Export aliases for FBXO17 gene to outside databases

Previous GC identifers: GC19M044124 GC19M044125


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO17:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs
class and it contains an F-box domain. Alternative splicing of this gene results in 2 transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able
to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes
sulfated glycans. Does not bind high-mannose glycoproteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO17 gene promoter:
         AhR   C/EBPbeta   POU2F1   POU2F1a   c-Myb   Tal-1beta   GATA-1   GATA-2   E47   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO17 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

FBXO17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO17 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039406:  view genomic region     (about GC identifiers)

Start:
39,405,904 bp from pter      End:
39,466,380 bp from pter
Size:
60,477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6 (See protein sequence)
Recommended Name: F-box only protein 17  
Size: 278 amino acids; 31479 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1
Sequence caution: Sequence=BAB71616.1; Type=Erroneous initiation;
Secondary accessions: Q96LQ4

Explore the universe of human proteins at neXtProt for FBXO17: NX_Q96EF6

FBXO17 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_079183.4  NP_680474.1  

ENSEMBL proteins: 
 ENSP00000399330   ENSP00000406754   ENSP00000221431   ENSP00000414954   ENSP00000292852  
Reactome Protein details: Q96EF6
Human Recombinant Protein Products: 
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Uscn Proteins for FBXO17

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005739mitochondrion ----
GO:0005759mitochondrial matrix ----
GO:0019005SCF ubiquitin ligase complex IDA18203720


FBXO17 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FBXO17 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR007397 F-box-assoc_dom
 IPR008979 Galactose-bd-like
 IPR001810 F-box_dom_cyclin-like

Graphical View of Domain Structure for InterPro Entry Q96EF6

ProtoNet protein and cluster: Q96EF6

1 Blocks protein family: IPB007397 F-box associated region

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Similarity: Contains 1 F-box domain
Similarity: Contains 1 FBA (F-box associated) domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able
to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes
sulfated glycans. Does not bind high-mannose glycoproteins

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidFBXO17 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001948glycoprotein binding IDA18203720
GO:0004828serine-tRNA ligase activity ----
GO:0005515protein binding IPI18203720
GO:0005524ATP binding ----


FBXO17 for ontologies           About GeneDecksing


3 GenomeRNAi human phenotypes for FBXO17:
 Decreased Wnt reporter activit  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Antigen processing: Ubiquitination & Proteasome degradation
Antigen processing: Ubiquitination & Proteasome degradation1.00
Polyubiquitination of substrate0.75
Class I MHC mediated antigen processing & presentation0.83
2Immune System
Immune System1.00
Adaptive Immune System0.59
3Selenium Metabolism and Selenoproteins
Selenium Metabolism and Selenoproteins1.00

Pathway sources
See GeneCards unified pathways
Show all pathways


1 BioSystems Pathway for FBXO17 
    Selenium Metabolism and Selenoproteins

5        Reactome Pathways for FBXO17
    Antigen processing: Ubiquitination & Proteasome degradation
Polyubiquitination of substrate
Adaptive Immune System
Class I MHC mediated antigen processing & presentation
Immune System



FBXO17 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO17

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/39 Interacting proteins for FBXO17 (Q96EF63 ENSP000002214314) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
InteractantInteraction Details
GeneCardExternal ID(s)
COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
FBXO27ENSP000002928534STRING: ENSP00000292853
SKP2ENSP000002742554STRING: ENSP00000274255
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006418tRNA aminoacylation for protein translation ----
GO:0006434seryl-tRNA aminoacylation ----
GO:0010467gene expression ----
GO:0030163protein catabolic process IEA--
GO:0097056selenocysteinyl-tRNA(Sec) biosynthetic process ----


FBXO17 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FBXO17
Search CenterWatch for drugs/clinical trials and news about FBXO17 / FBX17 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FBXO17 gene (2 alternative transcripts): 
NM_024907.5  NM_148169.1  

Unigene Cluster for FBXO17:

F-box protein 17
Hs.531770  [show with all ESTs]
Unigene Representative Sequence: AK226156
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000448145(uc010xuq.1) ENST00000430193(uc010xup.1 uc010xus.1)
ENST00000221431(uc002ojz.2 uc002oka.2 uc010xur.1) ENST00000455102
ENST00000292852(uc002okf.1 uc002okg.1)

miRNA
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hsa-miR-424 hsa-miR-15a hsa-miR-16 hsa-miR-195 hsa-miR-497 hsa-miR-15b
SwitchGear 3'UTR luciferase reporter plasmidFBXO17 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO17

Additional cDNA sequence: 

AF386743.1 AK057934.1 AK226156.1 BC012385.1 

6 DOTS entries:

DT.430048  DT.100798197  DT.75117710  DT.100023938  DT.100798198  DT.100798199 

24/123 AceView cDNA sequences (see all 123):

AI816297 AI815036 BF732367 AW161905 CR621585 NM_024907 BM928710 BQ652995 
H27972 BG421885 NM_148169 AI650332 AW161484 BF725266 BF725267 BF939290 
AA843945 AI087071 BX377501 BF432341 BX283641 AK057934 AU119595 AA026555 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO17 (see all 6)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
SP1:                          -     -                       -                                   -           -                                                   
SP2:        -                 -                             -                                   -                                                               
SP3:                                                                                                                                                            
SP4:                                                        -                                                                                                   
SP5:                                                                                                                                                            


ECgene alternative splicing isoforms for FBXO17

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBXO17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCTGCTGC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See FBXO17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXO17

SOURCE GeneReport for Unigene cluster: Hs.531770

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Tissue specificity: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and
brain

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for FBXO17 gene from 6/25 species (see all 25)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
zebrafish
(Danio rerio)
Actinopterygii sars26
seryl-tRNA synthetase 2
55(a)
1 → many
15(13530573-13555027)
fruit fly
(Drosophila melanogaster)
Insecta Aats-ser6
Seryl-tRNA synthetase
35(a)
1 → many
3R(11166407-11167939)
worm
(Caenorhabditis elegans)
Secernentea sars-26
Seryl tRNA Synthetase family member (srs-1)
32(a)
1 → many
IV(4357629-4359922)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATSRS6
Seryl-tRNA synthetase
30(a)
1 → many
1(4003846-4006739)
rice
(Oryza sativa)
Liliopsida --
seryl-tRNA synthetase, putative, expressed
33(a)
1 → many
11(23162052-23166458)
E. coli
(Escherichia coli)
Gamma proteobacteria serS6
seryl-tRNA synthetase, also charges selenocysteiny...
25(a)
possible ortholog
Chromosome(938651-939943)


ENSEMBL Gene Tree for FBXO17 (if available)
TreeFam Gene Tree for FBXO17 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/659 NCBI SNPs in FBXO17 are shown (see all 659    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1932304721,2
--39431615(+) GGAGGA/GTCAGG 2 -- ds50010--------
rs1417662671,2
--39431652(+) GGGATA/GCAGAA 2 -- ds50010--------
rs1850466141,2
--39431658(+) CAGAAA/GGGTAG 2 -- ds50010--------
rs1455365721,2
--39431833(+) GCTTCC/TGAGCT 2 -- ds50010--------
rs1477524441,2
--39431834(+) CTTCCA/GAGCTC 2 -- ds50010--------
rs1426363521,2
--39431842(+) CTCCCC/TTTCTT 2 -- ds50010--------
rs1890327561,2
--39431854(+) CTCACC/TATGGG 2 -- ds50010--------
rs1433729771,2
--39431878(+) TACTCC/GGGTGT 2 -- ds50010--------
rs1482996721,2
--39432001(+) TAACCC/TAGCGG 2 -- ds50010--------
rs1817420851,2
--39432072(+) TCTCAC/TGGCCT 2 -- ut310--------

HapMap Linkage Disequilibrium report for FBXO17 (39405904 - 39466380 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for FBXO17: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO17
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FBXO17 for disorders           About GeneDecksing

OMIM gene information: 609094    OMIM disorders: --

9 diseases for FBXO17:    About MalaCards
allergic contact dermatitis    severe acute respiratory syndrome    cerebrovascular accident    contact dermatitis
dermatitis    pneumonia    tuberculosis    malaria
mycobacterium tuberculosis


Export disorders for FBXO17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FBXO17 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with FBXO17)
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  1. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 2, 9 Ilyin G.P....Guguen-Guillouzo C. (2002)
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2, 9 Glenn K.A.... Paulson H.L. (2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. Skp1 stabilizes the conformation of F-box proteins. (PubMed id 21640084)1 Yoshida Y....Tanaka K. (2011)
  6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
  7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
  8. An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (2009)
  9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
  10. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115290 HGNC: 18754 AceView: FBXO17 Ensembl:ENSG00000104835 euGenes: HUgn115290
ECgene: FBXO17 H-InvDB: FBXO17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FBXO17 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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IP news from LifeMap Sciences, Inc.)
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Patent Information for FBXO17 gene:
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