Aliases for FBXO17 Gene
Aliases for FBXO17 Gene
External Ids for FBXO17 Gene
- HGNC: 18754
- Entrez Gene: 115290
- Ensembl: ENSG00000269190
- OMIM: 609094
- UniProtKB: Q96EF6
Previous HGNC Symbols for FBXO17 Gene
- FBXO26
Previous GeneCards Identifiers for FBXO17 Gene
- GC19M044124
- GC19M044125
- GC19M039406
- GC19M039432
Summaries for FBXO17 Gene
-
This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for FBXO17 Gene
FBXO17 (F-Box Protein 17) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO27.
UniProtKB/Swiss-Prot for FBXO17 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO17 Gene
Genomics for FBXO17 Gene
Regulatory Elements for FBXO17 Gene
Enhancers for FBXO17 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXO17 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXO17 Gene
- Chromosome:
- 19
- Start:
- 38,941,401 bp from pter
- End:
- 38,975,910 bp from pter
- Size:
- 34,510 bases
- Orientation:
- Minus strand
Genomic View for FBXO17 Gene
Genes around FBXO17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by Ensembl
- 19q13.2 by Entrez Gene
- 19q13.2 by HGNC
FBXO17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO17 Gene
Proteins for FBXO17 Gene
-
Protein details for FBXO17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96EF6-FBX17_HUMAN
- Recommended name:
- F-box only protein 17
- Protein Accession:
- Q96EF6
- Q96LQ4
Protein attributes for FBXO17 Gene
- Size:
- 278 amino acids
- Molecular mass:
- 31479 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=BAB71616.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FBXO17 Gene
Post-translational modifications for FBXO17 Gene
No Post-translational modifications
Other Protein References for FBXO17 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXO17
- Invitrogen Antibodies for FBXO17
- antibodies-online Antibodies for FBXO17: See all 22
- Search GeneTex for Antibodies for FBXO17
Protein Products
-
OriGene Purified Proteins for FBXO17
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXO17
- Origene Custom Protein Services for FBXO17
- antibodies-online Proteins for FBXO17: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXO17
-
Abcam proteins for FBXO17
Assay Products
- antibodies-online Kits for FBXO17: See all 15
No data available for DME Specific Peptides for FBXO17 Gene
Domains & Families for FBXO17 Gene
Gene Families for FBXO17 Gene
- HGNC:
Protein Domains for FBXO17 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXO17 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO17 Gene
Function for FBXO17 Gene
Molecular function for FBXO17 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001948 | glycoprotein binding | IDA | 18203720 |
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18203720 |
Phenotypes for FBXO17 Gene
- GenomeRNAi human phenotypes for FBXO17:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Increased shRNA abundance (Z-score > 2)
- Decreased viability ratio
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO17 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO17 gene
- Search ViGene Biosciences for FBXO17
CRISPR Products
-
OriGene CRISPR knockouts for FBXO17
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO17
- GenScript: Design CRISPR guide RNA sequences for FBXO17
miRNA for FBXO17 Gene
- miRTarBase miRNAs that target FBXO17
-
- hsa-mir-124-3p (MIRT022574)
- hsa-mir-6848-3p (MIRT513244)
- hsa-mir-6843-3p (MIRT513245)
- hsa-mir-3663-5p (MIRT513246)
- hsa-mir-4518 (MIRT513247)
- hsa-mir-1266-5p (MIRT513248)
- hsa-mir-660-3p (MIRT513249)
- hsa-mir-3664-3p (MIRT513250)
- hsa-mir-4692 (MIRT513251)
- hsa-mir-4514 (MIRT513252)
- hsa-mir-6715b-5p (MIRT513253)
- hsa-mir-4269 (MIRT513254)
- hsa-mir-4742-5p (MIRT513255)
- hsa-mir-4714-3p (MIRT513257)
- hsa-mir-335-3p (MIRT615882)
- hsa-mir-6131 (MIRT615883)
- hsa-mir-320e (MIRT615884)
miRNA Products
- Search ViGene Biosciences for FBXO17
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO17
- Browse OriGene Inhibitory RNA Products For FBXO17
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO17 gene
Cell Line Products
-
Horizon Cell Lines for FBXO17
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXO17 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXO17 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO17 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO17 Gene
Localization for FBXO17 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 18203720 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO17 Gene
Pathways & Interactions for FBXO17 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXO17 Gene
4 Reactome pathways for FBXO17 Gene
Interacting Proteins for FBXO17 Gene
Selected Interacting proteins:
ENSP00000292852
Q96EF6-FBX17_HUMAN
for FBXO17 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXO17 Gene
Transcripts for FBXO17 Gene
mRNA/cDNA for FBXO17 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (123) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO17
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO17
- GenScript: Design CRISPR guide RNA sequences for FBXO17
miRNA Products
- Search ViGene Biosciences for FBXO17
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXO17
- Browse OriGene Inhibitory RNA Products For FBXO17
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXO17 gene
Flow Cytometry Products
Expression for FBXO17 Gene
This gene is overexpressed in Vitreous humor (24.0), Ovary (22.2), and Fetal testis (12.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO17 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO17 Gene:
FBXO17SOURCE GeneReport for Unigene cluster for FBXO17 Gene:
Hs.531770mRNA Expression by UniProt/SwissProt for FBXO17 Gene:
Q96EF6-FBX17_HUMAN
Tissue specificity:
Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
Primer Products
-
OriGene qPCR primer pairs for FBXO17
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO17 Gene
Orthologs for FBXO17 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | FBXO17 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXO17 34 35 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO27 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo17 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo17 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany |
- Species where no ortholog for FBXO17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXO17 Gene
(4) SIMAP similar genes for FBXO17 Gene using alignment to 5 proteins:
Variants for FBXO17 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs151153509 | Uncertain significance | 38,945,018(+) | AGGCT(G/T)AGAAC | nc-transcript-variant, reference, stop-gained | |
| rs1000059468 | -- | 38,944,728(+) | GAGTG(G/T)TGCCC | intron-variant | |
| rs1000092632 | -- | 38,976,627(+) | TCTCC(C/T)GAGAA | upstream-variant-2KB | |
| rs1000190912 | -- | 38,962,540(+) | TTCTG(C/T)CGCAT | intron-variant | |
| rs1000288286 | -- | 38,969,198(+) | AATCC(C/T)AGCAC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2718541 | CNV | deletion | 23290073 |
| esv2718542 | CNV | deletion | 23290073 |
| esv2718543 | CNV | deletion | 23290073 |
| esv2762038 | CNV | loss | 21179565 |
| esv3583386 | CNV | loss | 25503493 |
| esv3644315 | CNV | loss | 21293372 |
| esv3644316 | CNV | loss | 21293372 |
| esv3644317 | CNV | gain | 21293372 |
Residual Variation Intolerance Score:
63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.80;
33.98% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXO17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO17
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO17 Gene
Disorders for FBXO17 Gene
Relevant External Links for FBXO17
No disorders were found for FBXO17 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO17 Gene
Publications for FBXO17 Gene
- Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 22 64
- A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
Products for FBXO17 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- OriGene Purified Proteins for FBXO17
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- OriGene qPCR primer pairs for FBXO17
- OriGene CRISPR knockouts for FBXO17
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- GenScript Custom overexpressing Cell Line Services for FBXO17
- GenScript: Design CRISPR guide RNA sequences for FBXO17
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Novus Biologicals Antibodies for FBXO17
- Novus Biologicals proteins and lysates for FBXO17
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FBXO17: See all 22
- antibodies-online Kits for FBXO17: See all 15
- antibodies-online Proteins for FBXO17: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for FBXO17
- Search GeneTex for Proteins for FBXO17
- ViGene Biosciences adenoviral particle packaged cDNA for FBXO17 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXO17 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FBXO17 gene
- Search ViGene Biosciences for FBXO17
- Horizon Cell Lines for FBXO17
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXO17
- VectorBuilder custom plasmid, inducible vectors for FBXO17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXO17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer