Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXO17 Gene

Aliases for FBXO17 Gene

  • F-Box Protein 17 2 3
  • F-Box Only Protein 26 2 3 4
  • Fbx17 3 4 6
  • FBX26 3 4 6
  • FBG4 3 4 6
  • F-Box Only Protein 17 2 3
  • FBXO26 3 4
  • F-Box Protein FBG4 3

External Ids for FBXO17 Gene

Previous Symbols for FBXO17 Gene

  • FBXO26

Summaries for FBXO17 Gene

Entrez Gene Summary for FBXO17 Gene

  • This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXO17 Gene

FBXO17 (F-Box Protein 17) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is NCCRP1.

UniProtKB/Swiss-Prot for FBXO17 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO17 Gene

Genomics for FBXO17 Gene

Genomic Location for FBXO17 Gene

Start:
38,941,401 bp from pter
End:
38,975,910 bp from pter
Size:
34,510 bases
Orientation:
Minus strand

Genomic View for FBXO17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO17 Gene

Regulatory Elements for FBXO17 Gene

Proteins for FBXO17 Gene

  • Protein details for FBXO17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EF6-FBX17_HUMAN
    Recommended name:
    F-box only protein 17
    Protein Accession:
    Q96EF6
    Secondary Accessions:
    • Q96LQ4

    Protein attributes for FBXO17 Gene

    Size:
    278 amino acids
    Molecular mass:
    31479 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=BAB71616.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO17 Gene

Proteomics data for FBXO17 Gene at MOPED

Post-translational modifications for FBXO17 Gene

No Post-translational modifications

Other Protein References for FBXO17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO17 Gene

Domains for FBXO17 Gene

Gene Families for FBXO17 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO17 Gene

UniProtKB/Swiss-Prot:

FBX17_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q96EF6
  • Contains 1 FBA (F-box associated) domain.:
    • Q96EF6
genes like me logo Genes that share domains with FBXO17: view

Function for FBXO17 Gene

Molecular function for FBXO17 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins

Gene Ontology (GO) - Molecular Function for FBXO17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IDA 18203720
GO:0005515 protein binding IPI 18203720
genes like me logo Genes that share ontologies with FBXO17: view

Phenotypes for FBXO17 Gene

genes like me logo Genes that share phenotypes with FBXO17: view

miRNA for FBXO17 Gene

miRTarBase miRNAs that target FBXO17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO17 Gene

Localization for FBXO17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO17 Gene COMPARTMENTS Subcellular localization image for FBXO17 gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXO17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IDA 18203720
genes like me logo Genes that share ontologies with FBXO17: view

Transcripts for FBXO17 Gene

Unigene Clusters for FBXO17 Gene

F-box protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO17 Gene

No ASD Table

Relevant External Links for FBXO17 Gene

GeneLoc Exon Structure for
FBXO17
ECgene alternative splicing isoforms for
FBXO17

Expression for FBXO17 Gene

mRNA expression in normal human tissues for FBXO17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO17 Gene

SOURCE GeneReport for Unigene cluster for FBXO17 Gene Hs.531770

mRNA Expression by UniProt/SwissProt for FBXO17 Gene

Q96EF6-FBX17_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
genes like me logo Genes that share expressions with FBXO17: view

Orthologs for FBXO17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO27 36
  • 85.58 (n)
  • 82.18 (a)
cow
(Bos Taurus)
Mammalia FBXO17 36
  • 90.89 (n)
  • 93.53 (a)
FBXO17 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO17 36
  • 87.85 (n)
  • 90.22 (a)
FBXO17 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo17 36
  • 83.15 (n)
  • 87 (a)
Fbxo17 16
Fbxo17 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 51 (a)
ManyToMany
-- 37
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fbxo17 36
  • 82.85 (n)
  • 83.09 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 47 (a)
OneToMany
Species with no ortholog for FBXO17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO17 Gene

ENSEMBL:
Gene Tree for FBXO17 (if available)
TreeFam:
Gene Tree for FBXO17 (if available)

Paralogs for FBXO17 Gene

Paralogs for FBXO17 Gene

Selected SIMAP similar genes for FBXO17 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FBXO17: view

Variants for FBXO17 Gene

Sequence variations from dbSNP and Humsavar for FBXO17 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs575 -- 38,942,143(+) CAGCA(C/T)GATGG utr-variant-3-prime, nc-transcript-variant
rs535171 -- 38,975,754(-) GCCCC(C/G)GGCGC utr-variant-5-prime, nc-transcript-variant
rs934421 -- 38,968,722(+) AAGCA(A/G)TAAAA intron-variant
rs1134180 -- 38,941,496(-) cttat(C/T)actgg utr-variant-3-prime, nc-transcript-variant
rs1865047 -- 38,946,894(+) AAGTG(C/T)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO17 Gene

Variant ID Type Subtype PubMed ID
esv2718541 CNV Deletion 23290073
esv2718542 CNV Deletion 23290073
esv2718543 CNV Deletion 23290073

Relevant External Links for FBXO17 Gene

HapMap Linkage Disequilibrium report
FBXO17

Disorders for FBXO17 Gene

(1) University of Copenhagen DISEASES for FBXO17 Gene

Relevant External Links for FBXO17

Genetic Association Database (GAD)
FBXO17
genes like me logo Genes that share disorders with FBXO17: view

No data available for UniProtKB/Swiss-Prot for FBXO17 Gene

Publications for FBXO17 Gene

  1. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin G.P. … Guguen-Guillouzo C. (Gene 2002) 3 4 23
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn K.A. … Paulson H.L. (J. Biol. Chem. 2008) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PMID: 17672918) Szafranski K. … Platzer M. (Genome Biol. 2007) 3

Products for FBXO17 Gene

Sources for FBXO17 Gene

Back to Top

Content