Aliases for FBXO17 Gene
External Ids for FBXO17 Gene
Previous HGNC Symbols for FBXO17 Gene
Previous GeneCards Identifiers for FBXO17 Gene
This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for FBXO17 Gene
FBXO17 (F-Box Protein 17) is a Protein Coding gene. Among its related pathways are Immune System and Selenium Metabolism and Selenoproteins. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO27.
UniProtKB/Swiss-Prot for FBXO17 Gene
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.