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FBXO17 Gene

protein-coding   GIFtS: 51
GCID: GC19M039432

F-Box Protein 17

(Previous name: F-box only protein 17)
(Previous symbol: FBXO26)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 171 2     F-Box Only Protein 171 2
FBXO261 2 3     FBX173 5
F-Box Only Protein 261 2 3     Fbx172
FBG42 3 5     F-Box Protein FBG42
FBX262 3 5     

External Ids:    HGNC: 187541   Entrez Gene: 1152902   Ensembl: ENSG000002691907   OMIM: 6090945   UniProtKB: Q96EF63   

Export aliases for FBXO17 gene to outside databases

Previous GC identifers: GC19M044124 GC19M044125 GC19M039406


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO17 Gene:
This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box
proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided
into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either
different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs
to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jul 2013)

GeneCards Summary for FBXO17 Gene:
FBXO17 (F-box protein 17) is a protein-coding gene. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO6.

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also
recognizes sulfated glycans. Does not bind high-mannose glycoproteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO17 gene promoter:
         AhR   C/EBPbeta   POU2F1   POU2F1a   c-Myb   Tal-1beta   GATA-1   GATA-2   E47   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO17 promoter sequence
   Search Chromatin IP Primers for FBXO17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

FBXO17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO17 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039432:  view genomic region     (about GC identifiers)

Start:
39,432,042 bp from pter      End:
39,466,550 bp from pter
Size:
34,509 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6 (See protein sequence)
Recommended Name: F-box only protein 17  
Size: 278 amino acids; 31479 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1
Sequence caution: Sequence=BAB71616.1; Type=Erroneous initiation;
Secondary accessions: Q96LQ4

Explore the universe of human proteins at neXtProt for FBXO17: NX_Q96EF6

Explore proteomics data for FBXO17 at MOPED


See FBXO17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_079183.4  NP_680474.1  

ENSEMBL proteins: 
 ENSP00000292852   ENSP00000470361   ENSP00000470101   ENSP00000470390   ENSP00000469852  
Reactome Protein details: Q96EF6

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FBXO: F-boxes / "other"

3 InterPro protein domains:
 IPR007397 F-box-assoc_dom
 IPR008979 Galactose-bd-like
 IPR001810 F-box_dom

Graphical View of Domain Structure for InterPro Entry Q96EF6

ProtoNet protein and cluster: Q96EF6

1 Blocks protein domain: IPB007397 F-box associated region

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Similarity: Contains 1 F-box domain
Similarity: Contains 1 FBA (F-box associated) domain


Find genes that share domains with FBXO17           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FBX17_HUMAN, Q96EF6
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also
recognizes sulfated glycans. Does not bind high-mannose glycoproteins

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001948glycoprotein binding IDA18203720
GO:0005515protein binding IPI18203720
     
Find genes that share ontologies with FBXO17           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for FBXO17:
 Decreased Wnt reporter activit  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FBXO17

miRNA
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miRTarBase miRNAs that target FBXO17:
hsa-mir-124-3p (MIRT022574)

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6 qRT-PCR Assays for microRNAs that regulate FBXO17:
hsa-miR-424 hsa-miR-15a hsa-miR-16 hsa-miR-195 hsa-miR-497 hsa-miR-15b
SwitchGear 3'UTR luciferase reporter plasmidFBXO17 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion4
nucleus2
cytosol1
extracellular1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0019005SCF ubiquitin ligase complex IDA18203720

Find genes that share ontologies with FBXO17           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for FBXO17 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84
2Selenium Metabolism and Selenoproteins
Selenium Metabolism and Selenoproteins


Find genes that share SuperPaths with FBXO17           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for FBXO17
    Selenium Metabolism and Selenoproteins

1 Reactome Pathway for FBXO17
    Antigen processing: Ubiquitination & Proteasome degradation


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO17
Interactions:

    Search GeneGlobe Interaction Network for FBXO17

3 Interacting proteins for FBXO17 (Q96EF63) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
COPS5Q929053I2D: score=2 
COPS6Q7L5N13I2D: score=2 
SKP1P632083I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030163protein catabolic process IEA--

Find genes that share ontologies with FBXO17           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FBXO17 (FBX17)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FBXO17 gene (2 alternative transcripts): 
NM_024907.6  NM_148169.2  

Unigene Cluster for FBXO17:

F-box protein 17
Hs.531770  [show with all ESTs]
Unigene Representative Sequence: AK226156
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000292852(uc002okf.1 uc002okg.1) ENST00000599418 ENST00000595329
ENST00000597696 ENST00000596025 ENST00000599598 ENST00000601394
miRNA
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hsa-miR-424 hsa-miR-15a hsa-miR-16 hsa-miR-195 hsa-miR-497 hsa-miR-15b
SwitchGear 3'UTR luciferase reporter plasmidFBXO17 3' UTR sequence
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat FBXO17

Additional mRNA sequence: 

AF386743.1 AK057934.1 AK226156.1 BC012385.1 

6 DOTS entries:

DT.430048  DT.100798197  DT.75117710  DT.100023938  DT.100798198  DT.100798199 

Selected AceView cDNA sequences (see all 123):

AI650332 AI087071 AI815036 NM_148169 BF725266 BQ652995 AW161484 CR621585 
AI816297 H27972 BF725267 AW161905 BF732367 BM928710 BG421885 BF939290 
AA843945 NM_024907 N68468 BX402189 BX402190 BX377501 BQ082066 BU734754 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FBXO17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCCTGCTGC
FBXO17 Expression
About this image

FBXO17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FBXO17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531770

UniProtKB/Swiss-Prot: FBX17_HUMAN, Q96EF6
Tissue specificity: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and
brain

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for FBXO17 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fbxo171 , 5 F-box protein 171, 5 83.15(n)1
87(a)1
  7 (16.90 cM)5
507601  NM_015796.21  NP_056611.21 
 287168045 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
47(a)
1 → many
GL343870.1(120044-129712)


ENSEMBL Gene Tree for FBXO17 (if available)
TreeFam Gene Tree for FBXO17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FBXO17 gene
FBXO62  FBXO272  FBXO22  FBXO442  NCCRP12  
4 SIMAP similar genes for FBXO17 using alignment to 5 protein entries:     FBX17_HUMAN (see all proteins):
SARS2    FBXO27    FBXO2    FBXO44

Find genes that share paralogs with FBXO17           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FBXO17 (see all 798)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1123473381,2
C--35897423(+) ATTCC-/T/TT  
        
TTTTT
1 -- int11CSA 2
rs1932304721,2
--39431615(+) GGAGGA/GTCAGG 2 -- ds50010--------
rs1417662671,2
--39431652(+) GGGATA/GCAGAA 2 -- ds50010--------
rs1850466141,2
--39431658(+) CAGAAA/GGGTAG 2 -- ds50010--------
rs1455365721,2
--39431833(+) GCTTCC/TGAGCT 2 -- ds50010--------
rs1477524441,2
--39431834(+) CTTCCA/GAGCTC 2 -- ds50010--------
rs1426363521,2
--39431842(+) CTCCCC/TTTCTT 2 -- ds50010--------
rs1890327561,2
--39431854(+) CTCACC/TATGGG 2 -- ds50010--------
rs1433729771,2
--39431878(+) TACTCC/GGGTGT 2 -- ds50010--------
rs1482996721,2
--39432001(+) TAACCC/TAGCGG 2 -- ds50010--------

HapMap Linkage Disequilibrium report for FBXO17 (39432042 - 39466550 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FBXO17:    About this table    
Variant IDTypeSubtypePubMed ID
esv2718543CNV Deletion23290073
esv2718541CNV Deletion23290073
esv2718542CNV Deletion23290073

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FBXO17
DNA2.0 Custom Variant and Variant Library Synthesis for FBXO17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609094    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for FBXO17:
Severe acute respiratory syndrome

Find genes that share disorders with FBXO17           About GenesLikeMe

Genetic Association Database (GAD): FBXO17

Export disorders for FBXO17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FBXO17 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with FBXO17)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A new subfamily of structurally related human F-box proteins. (PubMed id 12383498)1, 2, 9 Ilyin G.P....Guguen-Guillouzo C. (Gene 2002)
  2. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2, 9 Glenn K.A.... Paulson H.L. (J. Biol. Chem. 2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  6. Skp1 stabilizes the conformation of F-box proteins. (PubMed id 21640084)1 Yoshida Y....Tanaka K. (Biochem. Biophys. Res. Commun. 2011)
  7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  9. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (J. Cell. Sci. 2009)
  10. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115290 HGNC: 18754 AceView: FBXO17 Ensembl:ENSG00000269190 euGenes: HUgn115290
ECgene: FBXO17 H-InvDB: FBXO17

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FBXO17 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FBXO17 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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