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Aliases for FBXO17 Gene

Aliases for FBXO17 Gene

  • F-Box Protein 17 2 3 5
  • F-Box Only Protein 26 2 3 4
  • F-Box Only Protein 17 2 3
  • FBXO26 3 4
  • Fbx17 3 4
  • FBX26 3 4
  • FBG4 3 4
  • F-Box Protein FBG4 3

External Ids for FBXO17 Gene

Previous HGNC Symbols for FBXO17 Gene

  • FBXO26

Previous GeneCards Identifiers for FBXO17 Gene

  • GC19M044124
  • GC19M044125
  • GC19M039406
  • GC19M039432

Summaries for FBXO17 Gene

Entrez Gene Summary for FBXO17 Gene

  • This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXO17 Gene

FBXO17 (F-Box Protein 17) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. GO annotations related to this gene include glycoprotein binding. An important paralog of this gene is FBXO27.

UniProtKB/Swiss-Prot for FBXO17 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

Additional gene information for FBXO17 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO17 Gene

Genomics for FBXO17 Gene

Regulatory Elements for FBXO17 Gene

Enhancers for FBXO17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039125 1.7 Ensembl ENCODE dbSUPER 20 -151.4 -151444 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B HNRNPL FBL ENSG00000269172 ZNF780B ZNF780A ENSG00000269688 PAK4 EID2B RN7SL566P ENSG00000266963
GH19H038974 1.4 ENCODE dbSUPER 24.1 -0.7 -651 4 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 HNRNPL FBXO27 FBXO17 ENSG00000266963 EID2B MED29 ENSG00000269172 ENSG00000267375 ENSG00000269445 LOC105372399
GH19H038928 1.2 ENCODE 24.6 +45.9 45907 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF207 ZNF143 SARS2 FBXO17 SUPT5H FBL HNRNPL PAF1 PAK4 EID2B MRPS12 CCER2
GH19H039831 1.4 ENCODE dbSUPER 19.9 -857.5 -857541 3 HDGF PKNOX1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 FOS HNRNPL SNRPA FBL AKT2 RN7SL566P COQ8B PLEKHG2 ZNF780A ZNF780B ENSG00000269688
GH19H039427 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -456.2 -456237 9 MLX ZFP64 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZFP41 SSRP1 HNRNPL RPS16 ZNF780B FBL SUPT5H AKT2 EID2B RN7SL566P PLEKHG2 SAMD4B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO17 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109355 610 1801 ZFP64 SIN3A DMAP1 ZNF2 ZNF766 SP3 REST ZNF592 ZNF610 SMARCA4

Genomic Location for FBXO17 Gene

Chromosome:
19
Start:
38,941,401 bp from pter
End:
38,975,910 bp from pter
Size:
34,510 bases
Orientation:
Minus strand

Genomic View for FBXO17 Gene

Genes around FBXO17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO17 Gene

Proteins for FBXO17 Gene

  • Protein details for FBXO17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EF6-FBX17_HUMAN
    Recommended name:
    F-box only protein 17
    Protein Accession:
    Q96EF6
    Secondary Accessions:
    • Q96LQ4

    Protein attributes for FBXO17 Gene

    Size:
    278 amino acids
    Molecular mass:
    31479 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=BAB71616.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FBXO17 Gene

Post-translational modifications for FBXO17 Gene

No Post-translational modifications

Other Protein References for FBXO17 Gene

No data available for DME Specific Peptides for FBXO17 Gene

Domains & Families for FBXO17 Gene

Gene Families for FBXO17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FBXO17 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO17: view

No data available for UniProtKB/Swiss-Prot for FBXO17 Gene

Function for FBXO17 Gene

Molecular function for FBXO17 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

Phenotypes From GWAS Catalog for FBXO17 Gene

Gene Ontology (GO) - Molecular Function for FBXO17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 18203720
genes like me logo Genes that share ontologies with FBXO17: view
genes like me logo Genes that share phenotypes with FBXO17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO17 Gene

Localization for FBXO17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO17 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for FBXO17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 18203720
genes like me logo Genes that share ontologies with FBXO17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXO17 Gene

Pathways & Interactions for FBXO17 Gene

genes like me logo Genes that share pathways with FBXO17: view

Gene Ontology (GO) - Biological Process for FBXO17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXO17: view

No data available for SIGNOR curated interactions for FBXO17 Gene

Drugs & Compounds for FBXO17 Gene

No Compound Related Data Available

Transcripts for FBXO17 Gene

Unigene Clusters for FBXO17 Gene

F-box protein 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXO17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO17 Gene

No ASD Table

Relevant External Links for FBXO17 Gene

GeneLoc Exon Structure for
FBXO17
ECgene alternative splicing isoforms for
FBXO17

Expression for FBXO17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO17 Gene

Protein differential expression in normal tissues from HIPED for FBXO17 Gene

This gene is overexpressed in Vitreous humor (24.0), Ovary (22.2), and Fetal testis (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO17 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXO17 Gene:

FBXO17

SOURCE GeneReport for Unigene cluster for FBXO17 Gene:

Hs.531770

mRNA Expression by UniProt/SwissProt for FBXO17 Gene:

Q96EF6-FBX17_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, liver and kidney. Expressed at lower levels in spleen and brain.
genes like me logo Genes that share expression patterns with FBXO17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO17 Gene

Orthologs for FBXO17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO17 33 34
  • 90.89 (n)
dog
(Canis familiaris)
Mammalia FBXO17 33 34
  • 87.85 (n)
chimpanzee
(Pan troglodytes)
Mammalia FBXO27 33
  • 85.58 (n)
mouse
(Mus musculus)
Mammalia Fbxo17 33 16 34
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo17 33
  • 82.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
Species where no ortholog for FBXO17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXO17 Gene

ENSEMBL:
Gene Tree for FBXO17 (if available)
TreeFam:
Gene Tree for FBXO17 (if available)

Paralogs for FBXO17 Gene

Paralogs for FBXO17 Gene

(4) SIMAP similar genes for FBXO17 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FBXO17: view

Variants for FBXO17 Gene

Sequence variations from dbSNP and Humsavar for FBXO17 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs151153509 Uncertain significance 38,945,018(+) AGGCT(G/T)AGAAC nc-transcript-variant, reference, stop-gained
rs1000059468 -- 38,944,728(+) GAGTG(G/T)TGCCC intron-variant
rs1000092632 -- 38,976,627(+) TCTCC(C/T)GAGAA upstream-variant-2KB
rs1000190912 -- 38,962,540(+) TTCTG(C/T)CGCAT intron-variant
rs1000288286 -- 38,969,198(+) AATCC(C/T)AGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO17 Gene

Variant ID Type Subtype PubMed ID
esv2718541 CNV deletion 23290073
esv2718542 CNV deletion 23290073
esv2718543 CNV deletion 23290073
esv2762038 CNV loss 21179565
esv3583386 CNV loss 25503493
esv3644315 CNV loss 21293372
esv3644316 CNV loss 21293372
esv3644317 CNV gain 21293372

Variation tolerance for FBXO17 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO17 Gene

Disorders for FBXO17 Gene

Relevant External Links for FBXO17

Genetic Association Database (GAD)
FBXO17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO17

No disorders were found for FBXO17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO17 Gene

Publications for FBXO17 Gene

  1. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PMID: 18203720) Glenn KA … Paulson HL (The Journal of biological chemistry 2008) 3 4 22 60
  2. A new subfamily of structurally related human F-box proteins. (PMID: 12383498) Ilyin GP … Guguen-Guillouzo C (Gene 2002) 3 4 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for FBXO17 Gene

Sources for FBXO17 Gene

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