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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO16 Gene

protein-coding   GIFtS: 45
GCID: GC08M028206

F-Box Protein 16

(Previous name: F-box only protein 16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 161 2
F-Box Only Protein 161 2
FBX162 3

External Ids:    HGNC: 136181   Entrez Gene: 1575742   Ensembl: ENSG000002140507   OMIM: 6085195   UniProtKB: Q8IX293   

Export aliases for FBXO16 gene to outside databases

Previous GC identifers: GC08M028027 GC08M028307 GC08M028259 GC08M028341 GC08M026830


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO16 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for FBXO16 Gene: 
FBXO16 (F-box protein 16) is a protein-coding gene. Diseases associated with FBXO16 include fanconi's anemia, and intrahepatic cholangiocarcinoma. An important paralog of this gene is ECT2L.

UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO16 gene promoter:
         Egr-3   C/EBPbeta   Tal-1beta   C/EBPalpha   YY1   POU2F1   FOXO4   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO16 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21.1

FBXO16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M028206:  view genomic region     (about GC identifiers)

Start:
28,205,804 bp from pter      End:
28,347,835 bp from pter
Size:
142,032 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29 (See protein sequence)
Recommended Name: F-box only protein 16  
Size: 292 amino acids; 34588 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Secondary accessions: Q3T1B2 Q3T1B3 Q3T1B4
Alternative splicing: 2 isoforms:  Q8IX29-1   Q8IX29-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO16: NX_Q8IX29

Explore proteomics data for FBXO16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IX29

  • FBXO16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO16 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001245140.1  NP_758954.1  

    ENSEMBL proteins: 
     ENSP00000428902   ENSP00000431064   ENSP00000369604   ENSP00000341416   ENSP00000429687  
     ENSP00000429390   ENSP00000428683  

    Human Recombinant Protein Products for FBXO16: 
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    OriGene Protein Over-expression Lysate for FBXO16
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    Novus Biologicals FBXO16 Protein
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    Cloud-Clone Corp. Proteins for FBXO16 


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    Cloud-Clone Corp. ELISAs for FBXO16 
    Cloud-Clone Corp. CLIAs for FBXO16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q8IX29

    ProtoNet protein and cluster: Q8IX29

    UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29
    Similarity: Contains 1 F-box domain


    FBXO16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX16_HUMAN, Q8IX29
    Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
    degradation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FBXO16 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXO16:
     Decreased circadian period len  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO16 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXO16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO16 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO16 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of FBXO16 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for FBXO16 (Q8IX293 ENSP000003414164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO16 (FBX16)

    Search CenterWatch for drugs/clinical trials and news about FBXO16 / FBX16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO16 gene (2 alternative transcripts): 
    NM_001258211.1  NM_172366.3  

    Unigene Cluster for FBXO16:

    F-box protein 16
    Hs.741522  [show with all ESTs]
    Unigene Representative Sequence: NM_172366
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521548 ENST00000518248 ENST00000380254(uc003xgu.3 uc003xgv.3)
    ENST00000522609 ENST00000346498 ENST00000518734 ENST00000520481 ENST00000517436
    ENST00000517673 ENST00000518016 ENST00000519471
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FBXO16
    SwitchGear 3'UTR luciferase reporter plasmidFBXO16 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: FBXO16 (NM_172366)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO16
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                         Customized lentivirus expression plasmids for stable overexpression of FBXO16 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO16

    Additional mRNA sequence: 

    AF453435.1 BC074986.2 BC102026.1 BC102027.1 BC102028.1 

    10 DOTS entries:

    DT.97838265  DT.100030305  DT.427373  DT.99949598  DT.100787306  DT.75114880  DT.95362960  DT.86838818 
    DT.86840890  DT.97784112 

    24/401 AceView cDNA sequences (see all 401):

    AA347918 BQ448285 AI696929 BM703421 AA447796 AK023418 CK823018 BC001237 
    BC074986 BM673926 AW069582 CB046096 Z39516 AI335635 CA411695 AA490113 
    BP374773 AI057234 AW305193 AA574248 AB057659 AI371315 AI285881 AA701339 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAGAAAAA
    FBXO16 Expression
    About this image


    See FBXO16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO16

    SOURCE GeneReport for Unigene cluster: Hs.741522

    UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29
    Tissue specificity: Expressed in heart, spleen and colon

        SABiosciences Custom PCR Arrays for FBXO16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO16 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo161 , 5 F-box protein 161, 5 83.1(n)1
    86.01(a)1
      14 (34.19 cM)5
    507591  NM_015795.11  NP_056610.11 
     652667015 
    chicken
    (Gallus gallus)
    Aves FBXO161 F-box protein 16 70.45(n)
    65.2(a)
      771262  XM_001234554.1  XP_001234555.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO166
    F-box protein 16
    48(a)
    1 ↔ 1
    GL343529.1(38766-74916)
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo161 F-box protein 16 59.95(n)
    58.91(a)
      550375  NM_001017680.1  NP_001017680.1 


    ENSEMBL Gene Tree for FBXO16 (if available)
    TreeFam Gene Tree for FBXO16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO16 gene
    ECT2L2  
    2 SIMAP similar genes for FBXO16 using alignment to 6 protein entries:     FBX16_HUMAN (see all proteins):
    ADAM10    ECT2L

    FBXO16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1564 SNPs in FBXO16 are shown (see all 1564)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138152621,2
    C,F--28285446(+) AGGCAC/GAGGTT 2 -- int12Minor allele frequency- G:0.33WA CSA 3
    rs2022111611,2
    C--28285521(+) AAAAG-/AAAAAA 2 -- int10--------
    rs1492895831,2
    --28285689(+) GAACCG/TCAAGG 2 -- int10--------
    rs586004231,2
    C,F--28285709(+) TCTGTC/TGTCGA 2 -- int13Minor allele frequency- T:0.50WA CSA 6
    rs1898293761,2
    --28285752(+) CTAAGA/TTACCA 2 -- int10--------
    rs1130943191,2
    C--28285814(+) GTAGCC/TTTCTG 2 -- int10--------
    rs1814189141,2
    --28285958(+) ATACCA/GTAGGA 2 -- ut310--------
    rs118951,2
    C,F,O,A,H--28286071(-) CATGGA/GAAGAC 2 -- ut3132Minor allele frequency- N:0.00MN NA EA NS WA CSA 4593
    rs620019091,2
    C,F--28286124(+) GGGCCC/GAGGGT 2 -- ut312Minor allele frequency- G:0.39NS NA 198
    rs78146301,2
    C,F,H--28286143(+) GGATGC/TTGCAT 2 -- ut3112Minor allele frequency- T:0.04NS EA NA WA 1292

    HapMap Linkage Disequilibrium report for FBXO16 (28205804 - 28347835 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FBXO16:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678373CNV Deletion23128226
    esv2666579CNV Deletion23128226
    esv27064CNV Loss19812545
    nsv527661CNV Loss19592680
    dgv456n21CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO16
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608519    OMIM disorders: --

    4 diseases for FBXO16:    About MalaCards
    fanconi's anemia    intrahepatic cholangiocarcinoma    cholangiocarcinoma    anemia


    FBXO16 for disorders           About GeneDecksing


    Export disorders for FBXO16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FBXO16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression analysis of a novel human F-box only protein. (PubMed id 12243353)1, 2, 3, 9 Cheng H.... Mao Y. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    5. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. A family of mammalian F-box proteins. (PubMed id 10531037)1 Winston J.T....Harper J.W. (1999)
    9. Identification of a family of human F-box proteins. (PubMed id 10531035)1 Cenciarelli C....Pagano M. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 157574 HGNC: 13618 AceView: ZNF395andFBXO16 Ensembl:ENSG00000214050 euGenes: HUgn157574
    ECgene: FBXO16 H-InvDB: FBXO16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO16 gene:
    Search GeneIP for patents involving FBXO16

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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