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FBXO16 Gene(Protein Coding)

F-Box Protein 16

GCID:
GC08M028348
GIFtS:
45
Genes Participants
UDN Logo

Aliases for FBXO16 Gene

Aliases for FBXO16 Gene

  • F-Box Protein 16 2 3 5
  • F-Box Only Protein 16 2 3
  • FBX16 3 4

External Ids for FBXO16 Gene

Previous GeneCards Identifiers for FBXO16 Gene

  • GC08M028027
  • GC08M028307
  • GC08M028259
  • GC08M028341
  • GC08M026830
  • GC08M028206

Summaries for FBXO16 Gene

Entrez Gene Summary for FBXO16 Gene

  • This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for FBXO16 Gene

FBXO16 (F-Box Protein 16) is a Protein Coding gene. An important paralog of this gene is ECT2L.

UniProtKB/Swiss-Prot for FBXO16 Gene

  • Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO16 Gene

Genomics for FBXO16 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO16 Gene

Enhancers for FBXO16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G028363 1.6 Ensembl ENCODE dbSUPER 17.6 +120.4 120418 13.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 FZD3 FBXO16 ZNF395 ENSG00000253690 PNOC ENSG00000259366 PIR39512
GH08G028346 1.4 Ensembl ENCODE dbSUPER 10.6 +140.2 140183 7.9 TBP HDGF PKNOX1 SIN3A ZBTB7B ZBTB40 TCF12 ZNF121 ZNF766 EGR1 FZD3 FBXO16 EXTL3 NUGGC PNOC PIR39512 ZNF395
GH08G028561 0.9 ENCODE 11.3 -71.7 -71661 0.2 ELF3 RB1 ARID4B SIN3A FEZF1 BMI1 ZNF2 RAD21 YY1 TCF12 FZD3 EXTL3 FBXO16 PIR36324
GH08G028355 0.9 ENCODE dbSUPER 10.6 +134.6 134580 0.2 CTCF PKNOX1 CBX3 TRIM22 REST RAD21 ZNF143 SMC3 ZBTB33 PRDM1 ZNF395 FBXO16 FZD3 EXTL3 PNOC NUGGC PIR39512
GH08G028378 1.5 Ensembl ENCODE dbSUPER 6.2 +106.6 106585 10.1 FOXA2 PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 YY1 FOS SP3 SP5 FZD3 FBXO16 INTS9 ZNF395 PIR39512
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO16 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222774 -83 1200 PKNOX1 FOXA2 SIN3A DMAP1 ZNF2 YY1 ZNF121 ZNF143 KLF7 FOS

Transcription factor binding sites by QIAGEN in the FBXO16 gene promoter:

Genomic Location for FBXO16 Gene

Chromosome:
8
Start:
28,348,287 bp from pter
End:
28,490,318 bp from pter
Size:
142,032 bases
Orientation:
Minus strand

Genomic View for FBXO16 Gene

Genes around FBXO16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO16 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO16 Gene

Proteins for FBXO16 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBXO16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX29-FBX16_HUMAN
    Recommended name:
    F-box only protein 16
    Protein Accession:
    Q8IX29
    Secondary Accessions:
    • Q3T1B2
    • Q3T1B3
    • Q3T1B4

    Protein attributes for FBXO16 Gene

    Size:
    292 amino acids
    Molecular mass:
    34588 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

    Alternative splice isoforms for FBXO16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO16 Gene

Protein Expression for FBXO16 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO16 Gene

Domains & Families for FBXO16 Gene

Gene Families for FBXO16 Gene

HGNC:

Protein Domains for FBXO16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO16: view

No data available for UniProtKB/Swiss-Prot for FBXO16 Gene

Function for FBXO16 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO16 Gene

UniProtKB/Swiss-Prot Function:
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
genes like me logo Genes that share phenotypes with FBXO16: view

Animal Models for FBXO16 Gene

MGI Knock Outs for FBXO16:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO16 Gene

Localization for FBXO16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO16 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO16 Gene

Pathways & Interactions for FBXO16 Gene

SuperPathways for FBXO16 Gene

PathCards logo More details on SuperPathways for FBXO16
No Data Available

Interacting Proteins for FBXO16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369604%0d%0a9606.ENSP00000231487%0d%0a
Selected Interacting proteins: Q8IX29-FBX16_HUMAN ENSP00000369604 for FBXO16 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FBXO16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXO16 Gene

Drugs & Compounds for FBXO16 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FBXO16 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO16 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(401) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO16 Gene

F-box protein 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO16 Gene

No ASD Table

Relevant External Links for FBXO16 Gene

GeneLoc Exon Structure for
FBXO16
ECgene alternative splicing isoforms for
FBXO16

Expression for FBXO16 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO16 Gene

mRNA expression in normal human tissues for FBXO16 Gene
mRNA expression by BioGPS for FBXO16 GenemRNA expression by GTEx for FBXO16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO16 Gene

This gene is overexpressed in Pituitary (x6.3).

Protein differential expression in normal tissues from HIPED for FBXO16 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXO16 Gene



Protein tissue co-expression partners for FBXO16 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO16 Gene:

FBXO16

SOURCE GeneReport for Unigene cluster for FBXO16 Gene:

Hs.741522

mRNA Expression by UniProt/SwissProt for FBXO16 Gene:

Q8IX29-FBX16_HUMAN
Tissue specificity: Expressed in heart, spleen and colon.
genes like me logo Genes that share expression patterns with FBXO16: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO16 Gene

Orthologs for FBXO16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO16 34 35
  • 99.09 (n)
cow
(Bos Taurus)
 Mammalia FBXO16 34
  • 91.96 (n)
-- 35
  • 84 (a)
 OneToMany
-- 35
  • 80 (a)
 OneToMany
-- 35
  • 79 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia -- 35
  • 90 (a)
 OneToMany
LOC102155575 34
  • 88.26 (n)
-- 35
  • 82 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Fbxo16 34
  • 83.8 (n)
mouse
(Mus musculus)
 Mammalia Fbxo16 34 16 35
  • 83.1 (n)
oppossum
(Monodelphis domestica)
 Mammalia FBXO16 35
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia FBXO16 35
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FBXO16 34 35
  • 70.45 (n)
lizard
(Anolis carolinensis)
 Reptilia FBXO16 35
  • 47 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo16 34
  • 67.98 (n)
zebrafish
(Danio rerio)
 Actinopterygii fbxo16 34 35
  • 59.95 (n)
FBXO16 (2 of 2) 35
  • 42 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 28 (a)
 OneToMany
Species where no ortholog for FBXO16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO16 Gene

ENSEMBL:
Gene Tree for FBXO16 (if available)
TreeFam:
Gene Tree for FBXO16 (if available)

Paralogs for FBXO16 Gene

Paralogs for FBXO16 Gene

(2) SIMAP similar genes for FBXO16 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with FBXO16: view

Variants for FBXO16 Gene

Sequence variations from dbSNP and Humsavar for FBXO16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000003945 -- 28,436,654(+) ACACC(C/T)GTGTC intron-variant
rs1000010036 -- 28,465,817(+) TTGTT(G/T)TTGTT intron-variant
rs1000128817 -- 28,469,011(+) AAAAA(A/C)AAATT intron-variant
rs1000159683 -- 28,488,930(+) GTGCC(A/G)CACAA intron-variant
rs1000161621 -- 28,433,567(+) CTTCC(G/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO16 Gene

Variant ID Type Subtype PubMed ID
dgv2063e212 CNV loss 25503493
dgv456n21 CNV gain 19592680
esv2666579 CNV deletion 23128226
esv2678373 CNV deletion 23128226
esv27064 CNV loss 19812545
esv3543276 CNV deletion 23714750
esv3616738 CNV loss 21293372
esv3616739 CNV loss 21293372
nsv1109961 CNV deletion 24896259
nsv1125943 CNV tandem duplication 24896259
nsv527661 CNV loss 19592680

Variation tolerance for FBXO16 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.47; 95.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO16 Gene

Disorders for FBXO16 Gene

Relevant External Links for FBXO16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO16

No disorders were found for FBXO16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO16 Gene

Publications for FBXO16 Gene

  1. cDNA cloning and expression analysis of a novel human F-box only protein. (PMID: 12243353) Cheng H. … Mao Y. (Mol. Cells 2002) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3 64
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for FBXO16 Gene

Sources for FBXO16 Gene

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