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FBXO16 Gene

protein-coding   GIFtS: 43
GCID: GC08M028206

F-Box Protein 16

(Previous name: F-box only protein 16)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 161 2
FBX162 3 5
F-Box Only Protein 161 2

External Ids:    HGNC: 136181   Entrez Gene: 1575742   Ensembl: ENSG000002140507   OMIM: 6085195   UniProtKB: Q8IX293   

Export aliases for FBXO16 gene to outside databases

Previous GC identifers: GC08M028027 GC08M028307 GC08M028259 GC08M028341 GC08M026830


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO16 Gene:
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40
amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box
proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein
encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for FBXO16 Gene:
FBXO16 (F-box protein 16) is a protein-coding gene. An important paralog of this gene is ECT2L.

UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29
Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO16 gene promoter:
         Egr-3   C/EBPbeta   Tal-1beta   C/EBPalpha   YY1   POU2F1   FOXO4   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO16 promoter sequence
   Search Chromatin IP Primers for FBXO16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p21.1

FBXO16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO16 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M028206:  view genomic region     (about GC identifiers)

Start:
28,205,804 bp from pter      End:
28,347,835 bp from pter
Size:
142,032 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29 (See protein sequence)
Recommended Name: F-box only protein 16  
Size: 292 amino acids; 34588 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Secondary accessions: Q3T1B2 Q3T1B3 Q3T1B4
Alternative splicing: 2 isoforms:  Q8IX29-1   Q8IX29-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO16: NX_Q8IX29

Explore proteomics data for FBXO16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001245140.1  NP_758954.1  

    ENSEMBL proteins: 
     ENSP00000428902   ENSP00000431064   ENSP00000369604   ENSP00000341416   ENSP00000429687  
     ENSP00000429390   ENSP00000428683  

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    Cloud-Clone Corp. Proteins for FBXO16

     
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    antibodies-online proteins for FBXO16 (4 products) 

     
    antibodies-online peptides for FBXO16

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    antibodies-online antibodies for FBXO16 (15 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q8IX29

    ProtoNet protein and cluster: Q8IX29

    UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29
    Similarity: Contains 1 F-box domain


    Find genes that share domains with FBXO16           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX16_HUMAN, Q8IX29
    Function: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and
    degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXO16           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXO16:
     Decreased circadian period len  Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FBXO16

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    Predesigned siRNA for gene silencing in human, mouse, rat FBXO16

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO16
    Interactions:

        Search GeneGlobe Interaction Network for FBXO16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for FBXO16 (Q8IX293 ENSP000003414164) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDC6ENSP000002097284STRING: ENSP00000209728
    PSMD8ENSP000002150714STRING: ENSP00000215071
    PSMD2ENSP000003101294STRING: ENSP00000310129
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO16 (FBX16)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO16 gene (2 alternative transcripts): 
    NM_001258211.1  NM_172366.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521548 ENST00000518248 ENST00000380254(uc003xgu.3 uc003xgv.3)
    ENST00000522609 ENST00000346498 ENST00000518734 ENST00000520481 ENST00000517436
    ENST00000517673 ENST00000518016 ENST00000519471
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXO16
      QuantiFast Probe-based Assays in human, mouse, rat FBXO16

    Selected AceView cDNA sequences (see all 401):

    BP373671 BM675972 BE669771 AI700223 AA668916 BM452092 BM701325 AA490113 
    NM_172366 AI335635 AA347918 CA394921 AA441953 BF725049 BP374773 BQ448285 
    BF924312 BU580646 CN485142 AA625946 NM_018660 R63270 BC074986 BF445501 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAGAAAAA
    FBXO16 Expression
    About this image


    FBXO16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    FBXO16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO16 Protein Expression

    UniProtKB/Swiss-Prot: FBX16_HUMAN, Q8IX29
    Tissue specificity: Expressed in heart, spleen and colon

        Custom PCR Arrays for FBXO16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO16 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo161 , 5 F-box protein 161, 5 83.1(n)1
    86.01(a)1
      14 (34.19 cM)5
    507591  NM_015795.11  NP_056610.11 
     652667015 
    chicken
    (Gallus gallus)
    Aves FBXO161 F-box protein 16 70.45(n)
    65.2(a)
      771262  XM_004935881.1  XP_004935938.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO166
    F-box protein 16
    47(a)
    1 ↔ 1
    GL343529.1(38766-74916)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo161 F-box protein 16 67.98(n)
    71.94(a)
      100486001  XM_002939298.2  XP_002939344.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxo161 F-box protein 16 59.95(n)
    58.91(a)
      550375  NM_001017680.1  NP_001017680.1 


    ENSEMBL Gene Tree for FBXO16 (if available)
    TreeFam Gene Tree for FBXO16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO16 gene
    ECT2L2  
    2 SIMAP similar genes for FBXO16 using alignment to 6 protein entries:     FBX16_HUMAN (see all proteins):
    ADAM10    ECT2L

    Find genes that share paralogs with FBXO16           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO16 (see all 1564)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138152621,2
    C,F--28285446(+) AGGCAC/GAGGTT 2 -- int12Minor allele frequency- G:0.33WA CSA 3
    rs2022111611,2
    C--28285521(+) AAAAG-/AAAAAA 2 -- int10--------
    rs1492895831,2
    --28285689(+) GAACCG/TCAAGG 2 -- int10--------
    rs586004231,2
    C,F--28285709(+) TCTGTC/TGTCGA 2 -- int13Minor allele frequency- T:0.50WA CSA 6
    rs1898293761,2
    --28285752(+) CTAAGA/TTACCA 2 -- int10--------
    rs1130943191,2
    C--28285814(+) GTAGCC/TTTCTG 2 -- int10--------
    rs1814189141,2
    --28285958(+) ATACCA/GTAGGA 2 -- ut310--------
    rs118951,2
    C,F,O,A,H--28286071(-) CATGGA/GAAGAC 2 -- ut3132Minor allele frequency- N:0.00MN NA EA NS WA CSA 4593
    rs620019091,2
    C,F--28286124(+) GGGCCC/GAGGGT 2 -- ut312Minor allele frequency- G:0.39NS NA 198
    rs78146301,2
    C,F,H--28286143(+) GGATGC/TTGCAT 2 -- ut3112Minor allele frequency- T:0.04NS EA NA WA 1292

    HapMap Linkage Disequilibrium report for FBXO16 (28205804 - 28347835 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FBXO16:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678373CNV Deletion23128226
    esv2666579CNV Deletion23128226
    esv27064CNV Loss19812545
    nsv527661CNV Loss19592680
    dgv456n21CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO16
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608519    OMIM disorders: --


    Find genes that share disorders with FBXO16           About GenesLikeMe


    Export disorders for FBXO16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO16 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with FBXO16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression analysis of a novel human F-box only protein. (PubMed id 12243353)1, 2, 3, 9 Cheng H.... Mao Y. (Mol. Cells 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (Blood 2009)
    4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    5. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. A family of mammalian F-box proteins. (PubMed id 10531037)1 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    9. Identification of a family of human F-box proteins. (PubMed id 10531035)1 Cenciarelli C....Pagano M. (Curr. Biol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 157574 HGNC: 13618 AceView: ZNF395andFBXO16 Ensembl:ENSG00000214050 euGenes: HUgn157574
    ECgene: FBXO16 H-InvDB: FBXO16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXO16 gene:
    Search GeneIP for patents involving FBXO16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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