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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO15 Gene

protein-coding   GIFtS: 49
GCID: GC18M071740

F-box protein 15

(Previous name: F-box only protein 15 )
  Search for FBXO15
in our new
 Human Malady Compendium 
Biological research products
for FBXO15
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
F-Box Protein 151 2
FBX151 2 3 5
F-Box Only Protein 151 2
MGC396711

External Ids:    HGNC: 136171   Entrez Gene: 2014562   Ensembl: ENSG000001416657   OMIM: 6090935   UniProtKB: Q8NCQ53   

Export aliases for FBXO15 gene to outside databases

Previous GC identifers: GC18M069889 GC18M069891 GC18M068474


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO15:
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif.
SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination
targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO15 gene promoter:
         Oct-B1   POU2F2C   POU2F1   oct-B3   oct-B2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO15 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

FBXO15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO15 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M071740:  view genomic region     (about GC identifiers)

Start:
71,740,588 bp from pter      End:
71,815,100 bp from pter
Size:
74,513 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5 (See protein sequence)
Recommended Name: F-box only protein 15  
Size: 510 amino acids; 57258 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: B3KST3
Alternative splicing: 2 isoforms:  Q8NCQ5-1   Q8NCQ5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO15: NX_Q8NCQ5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NCQ5

  • FBXO15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136430.1  NP_689889.1  

    ENSEMBL proteins: 
     ENSP00000464177   ENSP00000393154   ENSP00000462143   ENSP00000462117   ENSP00000462151  
     ENSP00000463247   ENSP00000463378   ENSP00000463529   ENSP00000462361   ENSP00000269500  

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    Novus Biologicals FBXO15 Protein
    Novus Biologicals FBXO15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBXO15

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019005SCF ubiquitin ligase complex IEA--


    FBXO15 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FBXO15 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q8NCQ5

    ProtoNet protein and cluster: Q8NCQ5

    UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5
    Similarity: Contains 1 F-box domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By
    similarity)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXO15 (see all 7)
    OriGene shRNA RFP: FBXO15
    OriGene siRNA: FBXO15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXO15

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXO15 (see all 4)
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    Search LifeMap BioReagents cell lines for FBXO15

    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO15

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    FBXO15 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FBXO15:
     Decreased viability of wild-ty 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fbxo15):
     normal 

    FBXO15 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for FBXO15
        Oct4 in Mammalian ESC Pluripotency


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for FBXO15 (Q8NCQ53 ENSP000003931544) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    BTRCENSP000003592064STRING: ENSP00000359206
    CCNFENSP000003802564STRING: ENSP00000380256
    FBXL15ENSP000002248624STRING: ENSP00000224862
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO15
    Search CenterWatch for drugs/clinical trials and news about FBXO15 / FBX15 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO15 gene (2 alternative transcripts): 
    NM_001142958.1  NM_152676.2  

    Unigene Cluster for FBXO15:

    F-box protein 15
    Hs.664011  [show with all ESTs]
    Unigene Representative Sequence: AK093252
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577575 ENST00000583443 ENST00000419743(uc002llf.2) ENST00000581214
    ENST00000584425 ENST00000580806(uc002lld.2) ENST00000580088 ENST00000578399
    ENST00000579108 ENST00000579517 ENST00000585174 ENST00000582526 ENST00000580552
    ENST00000269500(uc002lle.2)

    miRNA
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    OriGene 3'-UTR Clone (see all 2): FBXO15
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    Inhib. RNA
    Products:
         
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    OriGene shRNA RFP: FBXO15
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO15 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO15

    Additional cDNA sequence: 

    AK093252.1 AK094215.1 BC029579.1 

    7 DOTS entries:

    DT.95368209  DT.100014600  DT.99927720  DT.302767  DT.100008632  DT.65284226  DT.100703671 

    24/46 AceView cDNA sequences (see all 46):

    NM_152676 BG220122 BQ638409 BG204907 AW772073 BC029579 BX111804 BX282012 
    CA426563 BG200793 AK094215 AW236444 BG193703 CA430036 AK093252 BI757101 
    BM662034 BI462582 BG188627 BG185321 BI827231 BE464323 BG202882 BP371274 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:              -                 -                                   -           -     -                     
    SP2:                                -                                   -           -     -                     
    SP3:                                      -     -     -                 -           -     -                     
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for FBXO15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAACCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    FBXO15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Induced pluripotent stem cell line 20D17 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line 492B4 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FBXO15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO15

    SOURCE GeneReport for Unigene cluster: Hs.664011
        SABiosciences Custom PCR Arrays for FBXO15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO15 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo151 , 5 F-box protein 151, 5 70.93(n)1
    58.35(a)1
      18 (57.53 cM)5
    507641  NM_015798.31  NP_056613.11 
     849351585 
    chicken
    (Gallus gallus)
    Aves FBXO151 F-box protein 15 63.9(n)
    53.46(a)
      421017  XM_419103.3  XP_419103.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO156
    --
    50(a)
    1 ↔ 1
    4(48982205-48993074)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX722355.12   -- 70.2(n)    BX722355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1619731 zgc:161973 47.85(n)
    36.07(a)
      556635  NM_001082806.1  NP_001076275.1 


    ENSEMBL Gene Tree for FBXO15 (if available)
    TreeFam Gene Tree for FBXO15 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1323 NCBI SNPs in FBXO15 are shown (see all 1323    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844720031,2
    --71740119(+) CCCACG/TGGACT 2 -- int10--------
    rs1892259571,2
    --71740170(+) ATTTCA/GGATAT 2 -- int10--------
    rs1435971351,2
    --71740226(+) ATACCA/GATATG 2 -- int10--------
    rs1812675021,2
    --71740349(+) AAAACC/TGTTAT 2 -- int10--------
    rs1842131941,2
    --71740374(+) CCCTAC/GACACA 2 -- int10--------
    rs1893243651,2
    --71740379(+) CACACA/GCATAC 2 -- int10--------
    rs353057871,2
    C,--71740382(+) CACAT-/ACACACA 2 -- int10--------
    rs798204181,2
    --71740451(+) CGAAGG/TGCGGA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1510222201,2
    --71740454(+) AGGGCA/GGAAGA 2 -- int10--------
    rs22987041,2
    C,H--71740470(-) AAAAGG/ATATTT 2 -- int16Minor allele frequency- A:0.00NS EA NA 600

    HapMap Linkage Disequilibrium report for FBXO15 (71740588 - 71815100 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FBXO15
         1 CNV: 73169

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO15
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXO15 for disorders           About MalaCards

    FBXO15 for disorders           About GeneDecksing

    OMIM gene information: 609093    OMIM disorders: --


    Export disorders for FBXO15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FBXO15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PubMed id 12665572)1, 3 Tokuzawa Y....Yamanaka S. (2003)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1 Jin J....Harper J.W. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. A family of mammalian F-box proteins. (PubMed id 10531037)1 Winston J.T....Harper J.W. (1999)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201456 HGNC: 13617 AceView: FBXO15 Ensembl:ENSG00000141665 euGenes: HUgn201456
    ECgene: FBXO15 H-InvDB: FBXO15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO15 gene:
    Search GeneIP for patents involving FBXO15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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