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FBXO15 Gene

protein-coding   GIFtS: 51
GCID: GC18M071740

F-Box Protein 15

(Previous name: F-box only protein 15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 151 2
FBX152 3 5
F-Box Only Protein 151 2

External Ids:    HGNC: 136171   Entrez Gene: 2014562   Ensembl: ENSG000001416657   OMIM: 6090935   UniProtKB: Q8NCQ53   

Export aliases for FBXO15 gene to outside databases

Previous GC identifers: GC18M069889 GC18M069891 GC18M068474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO15 Gene:
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXO15 Gene:
FBXO15 (F-box protein 15) is a protein-coding gene. Diseases associated with FBXO15 include venous thrombosis, and thyroiditis.

UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO15 gene promoter:
         Oct-B1   POU2F2C   POU2F1   oct-B3   oct-B2   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO15 promoter sequence
   Search Chromatin IP Primers for FBXO15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.3   Ensembl cytogenetic band:  18q22.3   HGNC cytogenetic band: 18q22.3

FBXO15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO15 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M071740:  view genomic region     (about GC identifiers)

Start:
71,740,588 bp from pter      End:
71,815,100 bp from pter
Size:
74,513 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5 (See protein sequence)
Recommended Name: F-box only protein 15  
Size: 510 amino acids; 57258 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: B3KST3
Alternative splicing: 2 isoforms:  Q8NCQ5-1   Q8NCQ5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO15: NX_Q8NCQ5

Explore proteomics data for FBXO15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136430.1  NP_689889.1  

    ENSEMBL proteins: 
     ENSP00000464177   ENSP00000393154   ENSP00000462143   ENSP00000462117   ENSP00000462151  
     ENSP00000463247   ENSP00000463378   ENSP00000463529   ENSP00000462361   ENSP00000269500  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXO: F-boxes / "other"

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q8NCQ5

    ProtoNet protein and cluster: Q8NCQ5

    UniProtKB/Swiss-Prot: FBX15_HUMAN, Q8NCQ5
    Similarity: Contains 1 F-box domain


    FBXO15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX15_HUMAN, Q8NCQ5
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FBXO15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXO15:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fbxo15):
     normal 

    FBXO15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO15
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO15
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    Sino Biological Human cDNA Clone for FBXO15
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019005SCF ubiquitin ligase complex IEA--

    FBXO15 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXO15 About    
    See pathways by source

    SuperPathContained pathways About
    1Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for FBXO15
        Oct4 in Mammalian ESC Pluripotency



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO15
    Interactions:

        Search GeneGlobe Interaction Network for FBXO15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO15 (Q8NCQ53 ENSP000003931544) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    BTRCENSP000003592064STRING: ENSP00000359206
    CCNFENSP000003802564STRING: ENSP00000380256
    FBXL15ENSP000002248624STRING: ENSP00000224862
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO15 (FBX15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXO15 gene (2 alternative transcripts): 
    NM_001142958.1  NM_152676.2  

    Unigene Cluster for FBXO15:

    F-box protein 15
    Hs.664011  [show with all ESTs]
    Unigene Representative Sequence: AK093252
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577575 ENST00000583443 ENST00000419743(uc002llf.2) ENST00000581214
    ENST00000584425 ENST00000580806(uc002lld.2) ENST00000580088 ENST00000578399
    ENST00000579108 ENST00000579517 ENST00000585174 ENST00000582526 ENST00000580552
    ENST00000269500(uc002lle.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXO15
      QuantiFast Probe-based Assays in human, mouse, rat FBXO15

    Additional mRNA sequence: 

    AK093252.1 AK094215.1 BC029579.1 

    7 DOTS entries:

    DT.95368209  DT.100014600  DT.99927720  DT.302767  DT.100008632  DT.65284226  DT.100703671 

    Selected AceView cDNA sequences (see all 46):

    BC029579 BG204907 AW236444 BG220122 AW772073 BQ638409 BX111804 BX282012 
    NM_152676 AK094215 CA426563 BG200793 BG193703 CA430036 BG188627 BM703365 
    BM687912 BG723854 BG202882 BP371274 BI829755 AK093252 BG185321 BG192131 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:              -                 -                                   -           -     -                     
    SP2:                                -                                   -           -     -                     
    SP3:                                      -     -     -                 -           -     -                     
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for FBXO15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAACCCTT
    FBXO15 Expression
    About this image


    FBXO15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Inner Cell Mass Cells Inner Cell Mass
             20D17
     
     Gonad (Reproductive System)    fully expand to see all 3 entries
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
    FBXO15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664011
        Custom PCR Arrays for FBXO15
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXO15 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo151 , 5 F-box protein 151, 5 70.93(n)1
    58.35(a)1
      18 (57.53 cM)5
    507641  NM_015798.31  NP_056613.11 
     849351585 
    chicken
    (Gallus gallus)
    Aves FBXO151 F-box protein 15 63.69(n)
    53.09(a)
      421017  XM_004935205.1  XP_004935262.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO156
    F-box protein 15
    47(a)
    1 ↔ 1
    4(48981562-48998907)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX722355.12   -- 70.2(n)    BX722355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1619731 zgc:161973 47.81(n)
    35.92(a)
      556635  NM_001082806.1  NP_001076275.1 


    ENSEMBL Gene Tree for FBXO15 (if available)
    TreeFam Gene Tree for FBXO15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO15 gene
    1 SIMAP similar gene for FBXO15 using alignment to 9 protein entries:     FBX15_HUMAN (see all proteins):
    FBXO11

    FBXO15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXO15 (see all 1530)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844720031,2
    --71740119(+) CCCACG/TGGACT 2 -- int10--------
    rs1892259571,2
    --71740170(+) ATTTCA/GGATAT 2 -- int10--------
    rs1435971351,2
    --71740226(+) ATACCA/GATATG 2 -- int10--------
    rs1812675021,2
    --71740349(+) AAAACC/TGTTAT 2 -- int10--------
    rs1842131941,2
    --71740374(+) CCCTAC/GACACA 2 -- int10--------
    rs1893243651,2
    --71740379(+) CACACA/GCATAC 2 -- int10--------
    rs353057871,2
    C--71740382(+) CACAT-/ACACACA 2 -- int10--------
    rs1138993101,2
    C--71740383(+) ACACA-/AC/CA 
            
    GAGTG
    2 -- int12CSA 4
    rs798204181,2
    C,F--71740451(+) CGAAGG/TGCGGA 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1510222201,2
    --71740454(+) AGGGCA/GGAAGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for FBXO15 (71740588 - 71815100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FBXO15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2355CNV Loss18451855
    esv27743CNV Loss19812545
    nsv909910CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO15
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609093    OMIM disorders: --

    2 diseases for FBXO15:    
    About MalaCards
    venous thrombosis    thyroiditis


    FBXO15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO15

    Export disorders for FBXO15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO15 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with FBXO15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PubMed id 12665572)1, 3 Tokuzawa Y....Yamanaka S. (Mol. Cell. Biol. 2003)
    4. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    5. A genome-wide association study of sleep habits and insomnia. (PubMed id 23728906)1 Byrne E.M....Wray N.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013)
    6. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PubMed id 23509962)1 Greliche N....TrAcgouAt D.A. (BMC Med. Genet. 2013)
    7. FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells. (PubMed id 23465077)1 Katayama K....Sugimoto Y. (Cancer Sci. 2013)
    8. A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. (PubMed id 23408906)1 Porcu E....Naitza S. (PLoS Genet. 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201456 HGNC: 13617 AceView: FBXO15 Ensembl:ENSG00000141665 euGenes: HUgn201456
    ECgene: FBXO15 H-InvDB: FBXO15

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXO15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for FBXO15 gene:
    Search GeneIP for patents involving FBXO15

    GeneCards and IP:
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