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Aliases for FBXO15 Gene

Aliases for FBXO15 Gene

  • F-Box Protein 15 2 3
  • FBX15 3 4 6
  • F-Box Only Protein 15 2 3

External Ids for FBXO15 Gene

Previous GeneCards Identifiers for FBXO15 Gene

  • GC18M069889
  • GC18M069891
  • GC18M071740
  • GC18M068474

Summaries for FBXO15 Gene

Entrez Gene Summary for FBXO15 Gene

  • Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO15 Gene

FBXO15 (F-Box Protein 15) is a Protein Coding gene. Among its related pathways are Oct4 in Mammalian ESC Pluripotency.

UniProtKB/Swiss-Prot for FBXO15 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO15 Gene

Genomics for FBXO15 Gene

Regulatory Elements for FBXO15 Gene

Genomic Location for FBXO15 Gene

Start:
74,073,252 bp from pter
End:
74,147,926 bp from pter
Size:
74,675 bases
Orientation:
Minus strand

Genomic View for FBXO15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO15 Gene

Proteins for FBXO15 Gene

  • Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCQ5-FBX15_HUMAN
    Recommended name:
    F-box only protein 15
    Protein Accession:
    Q8NCQ5
    Secondary Accessions:
    • B3KST3

    Protein attributes for FBXO15 Gene

    Size:
    510 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO15 Gene

Proteomics data for FBXO15 Gene at MOPED

Post-translational modifications for FBXO15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXO15 Gene

Domains for FBXO15 Gene

Gene Families for FBXO15 Gene

HGNC:
  • FBXO :F-boxes / "other"

Protein Domains for FBXO15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCQ5

UniProtKB/Swiss-Prot:

FBX15_HUMAN :
  • Q8NCQ5
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO15: view

Function for FBXO15 Gene

Molecular function for FBXO15 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXO15: view

Phenotypes for FBXO15 Gene

MGI mutant phenotypes for FBXO15:
inferred from 1 alleles
GenomeRNAi human phenotypes for FBXO15:
genes like me logo Genes that share phenotypes with FBXO15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXO15 Gene

Localization for FBXO15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO15 Gene COMPARTMENTS Subcellular localization image for FBXO15 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO15 Gene

Pathways for FBXO15 Gene

genes like me logo Genes that share pathways with FBXO15: view

Pathways by source for FBXO15 Gene

1 Qiagen pathway for FBXO15 Gene

Gene Ontology (GO) - Biological Process for FBXO15 Gene

None

Transcripts for FBXO15 Gene

Unigene Clusters for FBXO15 Gene

F-box protein 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4:
SP5:

Relevant External Links for FBXO15 Gene

GeneLoc Exon Structure for
FBXO15
ECgene alternative splicing isoforms for
FBXO15

Expression for FBXO15 Gene

mRNA expression in normal human tissues for FBXO15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene

This gene is overexpressed in Testis (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXO15 Gene

SOURCE GeneReport for Unigene cluster for FBXO15 Gene Hs.664011

genes like me logo Genes that share expressions with FBXO15: view

No data available for mRNA Expression by UniProt/SwissProt for FBXO15 Gene

Orthologs for FBXO15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO15 35
  • 73.69 (n)
  • 67.96 (a)
FBXO15 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO15 35
  • 80.91 (n)
  • 74.8 (a)
FBXO15 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo15 35
  • 70.93 (n)
  • 58.35 (a)
Fbxo15 16
Fbxo15 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO15 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO15 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo15 35
  • 77.9 (n)
  • 72.69 (a)
chicken
(Gallus gallus)
Aves FBXO15 35
  • 63.69 (n)
  • 53.09 (a)
FBXO15 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO15 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo15 35
  • 57.23 (n)
  • 46.12 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxo15 36
  • 30 (a)
OneToMany
FBXO15 (2 of 2) 36
  • 31 (a)
OneToMany
zgc:161973 35
  • 47.81 (n)
  • 35.92 (a)
Species with no ortholog for FBXO15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO15 Gene

ENSEMBL:
Gene Tree for FBXO15 (if available)
TreeFam:
Gene Tree for FBXO15 (if available)

Paralogs for FBXO15 Gene

Selected SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FBXO15: view

No data available for Paralogs for FBXO15 Gene

Variants for FBXO15 Gene

Sequence variations from dbSNP and Humsavar for FBXO15 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs880811 -- 74,077,201(+) GCTCA(A/G)CCACT intron-variant
rs951819 -- 74,082,700(+) GCCGC(A/G)GCACC intron-variant
rs951820 -- 74,082,569(+) AGCTG(A/G)AGGCC intron-variant
rs1113144 -- 74,107,551(-) ctacg(A/C)gtctc intron-variant
rs1573484 -- 74,075,229(-) GAGGT(C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO15 Gene

Variant ID Type Subtype PubMed ID
nsv909910 CNV Loss 21882294
nsv2355 CNV Loss 18451855
esv27743 CNV Loss 19812545

Relevant External Links for FBXO15 Gene

HapMap Linkage Disequilibrium report
FBXO15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO15 Gene

Disorders for FBXO15 Gene

Relevant External Links for FBXO15

Genetic Association Database (GAD)
FBXO15
genes like me logo Genes that share disorders with FBXO15: view

No data available for UniProtKB/Swiss-Prot for FBXO15 Gene

Publications for FBXO15 Gene

  1. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y. … Yamanaka S. (Mol. Cell. Biol. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for FBXO15 Gene

Sources for FBXO15 Gene

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