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Aliases for FBXO15 Gene

Aliases for FBXO15 Gene

  • F-Box Protein 15 2 3 5
  • F-Box Only Protein 15 2 3
  • FBX15 3 4

External Ids for FBXO15 Gene

Previous GeneCards Identifiers for FBXO15 Gene

  • GC18M069889
  • GC18M069891
  • GC18M071740
  • GC18M068474

Summaries for FBXO15 Gene

Entrez Gene Summary for FBXO15 Gene

  • Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO15 Gene

FBXO15 (F-Box Protein 15) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for FBXO15 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO15 Gene

Genomics for FBXO15 Gene

Regulatory Elements for FBXO15 Gene

Enhancers for FBXO15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F074146 1.1 ENCODE 9.5 -0.2 -213 3.8 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF407 TIMM21 CYB5A FBXO15
GH18F074139 1.3 FANTOM5 Ensembl ENCODE 7.3 +7.7 7694 1.3 ZNF316 STAT2 FOS NFE2 MAFK NFE2L2 NR4A1 JUNB MAFG MEF2D TIMM21 FBXO15 ENSG00000263655
GH18F074082 1.2 FANTOM5 Ensembl ENCODE 7.1 +64.2 64243 3.1 ELF3 CTCF KLF11 ZNF792 REST ZNF48 RAD21 KAT8 GABPB1 ZNF143 TIMM21 FBXO15 CYB5A ENSG00000263655
GH18F074062 0.9 FANTOM5 Ensembl ENCODE 7.5 +83.1 83063 3.7 ATF2 TIMM21 FBXO15 ENSG00000263655
GH18F074342 0.6 ENCODE 10 -194.7 -194736 0.2 CTCF ZNF654 TRIM22 ZNF384 REST RAD21 SMC3 PRDM1 CNDP1 FBXO15 TIMM21 C18orf63 FAUP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO15 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001516356 -535 2801 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for FBXO15 Gene

Chromosome:
18
Start:
74,073,343 bp from pter
End:
74,147,865 bp from pter
Size:
74,523 bases
Orientation:
Minus strand

Genomic View for FBXO15 Gene

Genes around FBXO15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO15 Gene

Proteins for FBXO15 Gene

  • Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCQ5-FBX15_HUMAN
    Recommended name:
    F-box only protein 15
    Protein Accession:
    Q8NCQ5
    Secondary Accessions:
    • B3KST3

    Protein attributes for FBXO15 Gene

    Size:
    510 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO15 Gene

Post-translational modifications for FBXO15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for FBXO15 (F-box protein 15/FBXO15)
  • Abcam antibodies for FBXO15

No data available for DME Specific Peptides for FBXO15 Gene

Domains & Families for FBXO15 Gene

Gene Families for FBXO15 Gene

Protein Domains for FBXO15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCQ5

UniProtKB/Swiss-Prot:

FBX15_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO15: view

Function for FBXO15 Gene

Molecular function for FBXO15 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXO15: view

Animal Models for FBXO15 Gene

MGI Knock Outs for FBXO15:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO15 Gene

Localization for FBXO15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO15 gene
Compartment Confidence
cytosol 5
mitochondrion 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO15 Gene

Pathways & Interactions for FBXO15 Gene

genes like me logo Genes that share pathways with FBXO15: view

Gene Ontology (GO) - Biological Process for FBXO15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with FBXO15: view

No data available for SIGNOR curated interactions for FBXO15 Gene

Transcripts for FBXO15 Gene

Unigene Clusters for FBXO15 Gene

F-box protein 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4:
SP5:

Relevant External Links for FBXO15 Gene

GeneLoc Exon Structure for
FBXO15
ECgene alternative splicing isoforms for
FBXO15

Expression for FBXO15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXO15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene

This gene is overexpressed in Testis (x11.0).

Protein differential expression in normal tissues from HIPED for FBXO15 Gene

This gene is overexpressed in Heart (52.2) and Testis (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO15 Gene



Protein tissue co-expression partners for FBXO15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO15 Gene:

FBXO15

SOURCE GeneReport for Unigene cluster for FBXO15 Gene:

Hs.664011
genes like me logo Genes that share expression patterns with FBXO15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXO15 Gene

Orthologs for FBXO15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO15 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO15 34 35
  • 80.91 (n)
rat
(Rattus norvegicus)
Mammalia Fbxo15 34
  • 77.9 (n)
cow
(Bos Taurus)
Mammalia FBXO15 34 35
  • 73.69 (n)
mouse
(Mus musculus)
Mammalia Fbxo15 34 16 35
  • 70.93 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXO15 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO15 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXO15 34 35
  • 63.69 (n)
lizard
(Anolis carolinensis)
Reptilia FBXO15 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo15 34
  • 57.23 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:161973 34
  • 47.81 (n)
FBXO15 (2 of 2) 35
  • 31 (a)
OneToMany
fbxo15 35
  • 30 (a)
OneToMany
Species where no ortholog for FBXO15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO15 Gene

ENSEMBL:
Gene Tree for FBXO15 (if available)
TreeFam:
Gene Tree for FBXO15 (if available)

Paralogs for FBXO15 Gene

(1) SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FBXO15: view

No data available for Paralogs for FBXO15 Gene

Variants for FBXO15 Gene

Sequence variations from dbSNP and Humsavar for FBXO15 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10514109 -- 74,080,897(+) GTCAC(A/G)TTCAC intron-variant
rs10514110 -- 74,133,029(+) AGTAA(C/T)GCTTA intron-variant
rs10514111 -- 74,137,360(+) AAAAC(A/T)TCATA intron-variant
rs10514112 -- 74,139,133(+) TTAAA(C/T)GCGCC intron-variant
rs111228453 -- 74,074,264(+) GTCCA(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO15 Gene

Variant ID Type Subtype PubMed ID
nsv577650 CNV loss 21841781
nsv2355 CNV deletion 18451855
nsv1058079 CNV gain 25217958
esv3643108 CNV loss 21293372
esv3643105 CNV loss 21293372
esv27743 CNV loss 19812545
dgv3400n100 CNV gain 25217958

Variation tolerance for FBXO15 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO15 Gene

Disorders for FBXO15 Gene

Relevant External Links for FBXO15

Genetic Association Database (GAD)
FBXO15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO15

No disorders were found for FBXO15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO15 Gene

Publications for FBXO15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y. … Yamanaka S. (Mol. Cell. Biol. 2003) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3 64

Products for FBXO15 Gene

Sources for FBXO15 Gene

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