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Aliases for FBXO15 Gene

Aliases for FBXO15 Gene

  • F-Box Protein 15 2 3 5
  • FBX15 3 4
  • F-Box Only Protein 15 2

External Ids for FBXO15 Gene

Previous GeneCards Identifiers for FBXO15 Gene

  • GC18M069889
  • GC18M069891
  • GC18M071740
  • GC18M068474

Summaries for FBXO15 Gene

Entrez Gene Summary for FBXO15 Gene

  • Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO15 Gene

FBXO15 (F-Box Protein 15) is a Protein Coding gene. Among its related pathways are Oct4 in Mammalian ESC Pluripotency.

UniProtKB/Swiss-Prot for FBXO15 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO15 Gene

Genomics for FBXO15 Gene

Regulatory Elements for FBXO15 Gene

Enhancers for FBXO15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO15 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO15 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO15 Gene

74,073,343 bp from pter
74,147,865 bp from pter
74,523 bases
Minus strand

Genomic View for FBXO15 Gene

Genes around FBXO15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO15 Gene

Proteins for FBXO15 Gene

  • Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box only protein 15
    Protein Accession:
    Secondary Accessions:
    • B3KST3

    Protein attributes for FBXO15 Gene

    510 amino acids
    Molecular mass:
    57258 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXO15 Gene


neXtProt entry for FBXO15 Gene

Proteomics data for FBXO15 Gene at MOPED

Post-translational modifications for FBXO15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for FBXO15 (F-box protein 15/FBXO15)
  • Abcam antibodies for Fbx15

No data available for DME Specific Peptides for FBXO15 Gene

Domains & Families for FBXO15 Gene

Gene Families for FBXO15 Gene

Protein Domains for FBXO15 Gene


Suggested Antigen Peptide Sequences for FBXO15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXO15: view

Function for FBXO15 Gene

Molecular function for FBXO15 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXO15: view

Animal Models for FBXO15 Gene

MGI Knock Outs for FBXO15:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO15 Gene

Localization for FBXO15 Gene

Subcellular locations from

Jensen Localization Image for FBXO15 Gene COMPARTMENTS Subcellular localization image for FBXO15 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXO15 Gene

Pathways & Interactions for FBXO15 Gene

genes like me logo Genes that share pathways with FBXO15: view

Pathways by source for FBXO15 Gene

1 Qiagen pathway for FBXO15 Gene

Gene Ontology (GO) - Biological Process for FBXO15 Gene


No data available for SIGNOR curated interactions for FBXO15 Gene

Drugs & Compounds for FBXO15 Gene

No Compound Related Data Available

Transcripts for FBXO15 Gene

Unigene Clusters for FBXO15 Gene

F-box protein 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -

Relevant External Links for FBXO15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXO15 Gene

mRNA expression in normal human tissues for FBXO15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene

This gene is overexpressed in Testis (x11.0).

Protein differential expression in normal tissues from HIPED for FBXO15 Gene

This gene is overexpressed in Heart (52.2) and Testis (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO15 Gene

SOURCE GeneReport for Unigene cluster for FBXO15 Gene Hs.664011

genes like me logo Genes that share expression patterns with FBXO15: view

Protein tissue co-expression partners for FBXO15 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXO15 Gene

Orthologs for FBXO15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXO15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXO15 35
  • 73.69 (n)
  • 67.96 (a)
FBXO15 36
  • 68 (a)
(Canis familiaris)
Mammalia FBXO15 35
  • 80.91 (n)
  • 74.8 (a)
FBXO15 36
  • 74 (a)
(Mus musculus)
Mammalia Fbxo15 35
  • 70.93 (n)
  • 58.35 (a)
Fbxo15 16
Fbxo15 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Fbxo15 35
  • 77.9 (n)
  • 72.69 (a)
(Monodelphis domestica)
Mammalia FBXO15 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia FBXO15 36
  • 49 (a)
(Pan troglodytes)
Mammalia FBXO15 36
  • 99 (a)
(Gallus gallus)
Aves FBXO15 35
  • 63.69 (n)
  • 53.09 (a)
FBXO15 36
  • 53 (a)
(Anolis carolinensis)
Reptilia FBXO15 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo15 35
  • 57.23 (n)
  • 46.12 (a)
(Danio rerio)
Actinopterygii zgc:161973 35
  • 47.81 (n)
  • 35.92 (a)
fbxo15 36
  • 30 (a)
FBXO15 (2 of 2) 36
  • 31 (a)
Species with no ortholog for FBXO15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXO15 Gene

Gene Tree for FBXO15 (if available)
Gene Tree for FBXO15 (if available)

Paralogs for FBXO15 Gene

(1) SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FBXO15: view

No data available for Paralogs for FBXO15 Gene

Variants for FBXO15 Gene

Sequence variations from dbSNP and Humsavar for FBXO15 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35815390 - 74,073,508(+) AAGAT(A/G)AAGGA reference, missense
rs1573484 -- 74,075,229(-) GAGGT(C/T)CTCTG intron-variant
rs7231106 -- 74,127,164(+) GTGCT(C/T)AATAA intron-variant
rs8086078 -- 74,132,341(+) ATGGA(C/G)CCTTG intron-variant
rs8086350 -- 74,142,775(+) CCTGG(G/T)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO15 Gene

Variant ID Type Subtype PubMed ID
nsv909910 CNV Loss 21882294
nsv2355 CNV Loss 18451855
esv27743 CNV Loss 19812545

Variation tolerance for FBXO15 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXO15 Gene

Disorders for FBXO15 Gene

Relevant External Links for FBXO15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXO15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO15 Gene

Publications for FBXO15 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y. … Yamanaka S. (Mol. Cell. Biol. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3
  5. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. (PMID: 24703837) Chen B.B. … Mallampalli R.K. (Cell Rep 2014) 3

Products for FBXO15 Gene

Sources for FBXO15 Gene