Aliases for FBXO15 Gene
External Ids for FBXO15 Gene
- HGNC: 13617
- Entrez Gene: 201456
- Ensembl: ENSG00000141665
- OMIM: 609093
- UniProtKB: Q8NCQ5
Previous GeneCards Identifiers for FBXO15 Gene
- GC18M069889
- GC18M069891
- GC18M071740
- GC18M068474
Summaries for FBXO15 Gene
-
Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXO15 Gene
FBXO15 (F-Box Protein 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot for FBXO15 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO15 Gene
Genomics for FBXO15 Gene
Regulatory Elements for FBXO15 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH18G074146 | 1.1 | ENCODE | 9.5 | -0.2 | -213 | 3.8 | PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 | ZNF407 TIMM21 CYB5A FBXO15 |
| GH18G074082 | 1.2 | FANTOM5 Ensembl ENCODE | 7.1 | +64.2 | 64243 | 3.1 | ELF3 CTCF ZNF792 ZNF48 RAD21 SMC3 ZNF143 NR2F6 THAP11 KLF11 | TIMM21 FBXO15 CYB5A ENSG00000263655 |
| GH18G074342 | 0.6 | ENCODE | 10 | -194.7 | -194736 | 0.2 | CTCF ZNF654 TRIM22 ZNF384 REST RAD21 SMC3 PRDM1 | CNDP1 TIMM21 FBXO15 C18orf63 FAUP1 |
| GH18G074062 | 0.7 | FANTOM5 ENCODE | 7.5 | +83.1 | 83063 | 3.7 | CTCF ATF2 | TIMM21 FBXO15 ENSG00000263655 |
| GH18G074141 | 0.7 | Ensembl | 7.3 | +7.5 | 7465 | 0.4 | HDGF ZNF639 PKNOX1 NR4A1 JUNB ZBTB40 ZNF592 FOSL1 MEF2D STAT2 | TIMM21 FBXO15 ENSG00000263655 |
- Transcription factor binding sites by QIAGEN in the FBXO15 gene promoter:
Regulatory Element Products
Genomic Location for FBXO15 Gene
- Chromosome:
- 18
- Start:
- 74,073,343 bp from pter
- End:
- 74,147,865 bp from pter
- Size:
- 74,523 bases
- Orientation:
- Minus strand
Genomic View for FBXO15 Gene
- Cytogenetic band:
-
- 18q22.3 by Ensembl
- 18q22.3 by Entrez Gene
- 18q22.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXO15 Gene
Proteins for FBXO15 Gene
-
Protein details for FBXO15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NCQ5-FBX15_HUMAN
- Recommended name:
- F-box only protein 15
- Protein Accession:
- Q8NCQ5
- B3KST3
Protein attributes for FBXO15 Gene
- Size:
- 510 amino acids
- Molecular mass:
- 57258 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
Protein Expression for FBXO15 Gene
Post-translational modifications for FBXO15 Gene
Other Protein References for FBXO15 Gene
Antibody Products
- R&D Systems Antibodies for FBXO15 (F-box protein 15/FBXO15)
-
Custom Antibody ServicesOriGene Antibodies for FBXO15
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-
Abcam antibodies for FBXO15
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- antibodies-online Antibodies for FBXO15: See all 44
- GeneTex FBXO15 antibody for FBXO15
Protein Products
-
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- antibodies-online Proteins for FBXO15: See all 6
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-
Abcam proteins for FBXO15
Assay Products
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- antibodies-online Kits for FBXO15: See all 15
No data available for DME Specific Peptides for FBXO15 Gene
Domains & Families for FBXO15 Gene
Gene Families for FBXO15 Gene
- HGNC:
Suggested Antigen Peptide Sequences for FBXO15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXO15 Gene
Function for FBXO15 Gene
Molecular function for FBXO15 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXO15 Gene
- MGI mutant phenotypes for FBXO15:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXO15:
Animal Models for FBXO15 Gene
- MGI Knock Outs for FBXO15:
-
- Fbxo15 tm1Yam
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for FBXO15
-
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miRNA Products
- Search ViGene Biosciences for FBXO15
Inhibitory RNA Products
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-
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Clone Products
- Sino Biological Human cDNA Clone for FBXO15
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Cell Line Products
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXO15 Gene
Localization for FBXO15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXO15 Gene
Pathways & Interactions for FBXO15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Oct4 in Mammalian ESC Pluripotency | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for FBXO15 Gene
4 Reactome pathways for FBXO15 Gene
1 Qiagen pathway for FBXO15 Gene
Interacting Proteins for FBXO15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXO15 Gene
Transcripts for FBXO15 Gene
mRNA/cDNA for FBXO15 Gene
- (8) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for FBXO15
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXO15
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
- Sino Biological Human cDNA Clone for FBXO15
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- Addgene plasmids for FBXO15
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||
| SP5: |
Expression for FBXO15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
- 492B4
- 440A-3
- 20D17
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- XX Germ Cells Ovigerous Cord
- XY Germ Cells Testis Cord
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
mRNA differential expression in normal tissues according to GTEx for FBXO15 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO15 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXO15 Gene:
FBXO15SOURCE GeneReport for Unigene cluster for FBXO15 Gene:
Hs.664011Evidence on tissue expression from TISSUES for FBXO15 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for FBXO15
-
OriGene qPCR primer pairs and template standards for FBXO15
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO15 Gene
Orthologs for FBXO15 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXO15 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXO15 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxo15 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXO15 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxo15 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXO15 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXO15 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXO15 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXO15 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxo15 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:161973 34 |
|
||
| FBXO15 (2 of 2) 35 |
|
OneToMany | |||
| fbxo15 35 |
|
OneToMany |
- Species where no ortholog for FBXO15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXO15 Gene
(1) SIMAP similar genes for FBXO15 Gene using alignment to 9 proteins:
No data available for Paralogs for FBXO15 Gene
Variants for FBXO15 Gene
| SNP ID | Clin | Chr 18 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000085878 | -- | 74,075,014(+) | GAGGA(G/T)CGCAG | intron-variant | |
| rs1000093293 | -- | 74,116,499(+) | TCCAT(A/T)CAGAA | intron-variant | |
| rs1000194548 | -- | 74,147,177(+) | GCCCC(C/G)CACCC | intron-variant, upstream-variant-2KB | |
| rs1000227084 | -- | 74,147,932(+) | GGCAC(C/T)GCGCC | upstream-variant-2KB | |
| rs1000229859 | -- | 74,136,177(+) | TGTGT(A/G)TTTTT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3400n100 | CNV | gain | 25217958 |
| esv27743 | CNV | loss | 19812545 |
| esv3643105 | CNV | loss | 21293372 |
| esv3643108 | CNV | loss | 21293372 |
| nsv1058079 | CNV | gain | 25217958 |
| nsv2355 | CNV | deletion | 18451855 |
| nsv577650 | CNV | loss | 21841781 |
Relevant External Links for FBXO15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXO15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO15 Gene
Disorders for FBXO15 Gene
Relevant External Links for FBXO15
No disorders were found for FBXO15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXO15 Gene
Publications for FBXO15 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. (PMID: 12665572) Tokuzawa Y. … Yamanaka S. (Mol. Cell. Biol. 2003) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. (PMID: 24703837) Chen B.B. … Mallampalli R.K. (Cell Rep 2014) 3 64
Products for FBXO15 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXO15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




