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Aliases for FBXO11 Gene

Aliases for FBXO11 Gene

  • F-Box Protein 11 2 3
  • FBX11 3 4 6
  • PRMT9 3 4 6
  • VIT1 3 4 6
  • Ubiquitin Protein Ligase E3 Component N-Recognin 6 2 3
  • Protein Arginine N-Methyltransferase 9 3 4
  • Vitiligo-Associated Protein 1 3 4
  • F-Box Only Protein 11 2 3
  • Vitiligo-Associated Protein VIT-1 3
  • UG063H01 3
  • VIT-1 4
  • UBR6 3

External Ids for FBXO11 Gene

Previous GeneCards Identifiers for FBXO11 Gene

  • GC02U990127
  • GC02M048202
  • GC02M047991
  • GC02M048008
  • GC02M047945
  • GC02M047869
  • GC02M048016

Summaries for FBXO11 Gene

Entrez Gene Summary for FBXO11 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for FBXO11 Gene

FBXO11 (F-Box Protein 11) is a Protein Coding gene. Among its related pathways are p53 pathway. GO annotations related to this gene include ubiquitin-protein transferase activity and protein-arginine N-methyltransferase activity. An important paralog of this gene is FBXO10.

UniProtKB/Swiss-Prot for FBXO11 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Gene Wiki entry for FBXO11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO11 Gene

Genomics for FBXO11 Gene

Regulatory Elements for FBXO11 Gene

Genomic Location for FBXO11 Gene

Start:
47,789,316 bp from pter
End:
47,906,385 bp from pter
Size:
117,070 bases
Orientation:
Minus strand

Genomic View for FBXO11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXO11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO11 Gene

Proteins for FBXO11 Gene

  • Protein details for FBXO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XK2-FBX11_HUMAN
    Recommended name:
    F-box only protein 11
    Protein Accession:
    Q86XK2
    Secondary Accessions:
    • A1L491
    • Q52ZP1
    • Q53EP7
    • Q53RT5
    • Q8IXG3
    • Q96E90
    • Q9H6V8
    • Q9H9L1
    • Q9NR14
    • Q9UFK1
    • Q9UHI1
    • Q9UKC2

    Protein attributes for FBXO11 Gene

    Size:
    927 amino acids
    Molecular mass:
    103585 Da
    Quaternary structure:
    • Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.
    SequenceCaution:
    • Sequence=AAF76888.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAN76518.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305}; Sequence=AAY24083.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO11 Gene

neXtProt entry for FBXO11 Gene

Proteomics data for FBXO11 Gene at MOPED

Post-translational modifications for FBXO11 Gene

  • Ubiquitination at Lys197
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXO11 Gene

Domains for FBXO11 Gene

Gene Families for FBXO11 Gene

HGNC:
  • FBXO :F-boxes / "other"
  • UBR :Ubiquitin protein ligase E3 component n-recognins
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q86XK2

UniProtKB/Swiss-Prot:

FBX11_HUMAN :
  • Q86XK2
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 19 PbH1 repeats.
  • Contains 1 UBR-type zinc finger.
genes like me logo Genes that share domains with FBXO11: view

Function for FBXO11 Gene

Molecular function for FBXO11 Gene

UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Gene Ontology (GO) - Molecular Function for FBXO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 17098746
GO:0008270 zinc ion binding IEA --
GO:0016274 protein-arginine N-methyltransferase activity IDA 16487488
genes like me logo Genes that share ontologies with FBXO11: view
genes like me logo Genes that share phenotypes with FBXO11: view

miRNA for FBXO11 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXO11 Gene

Localization for FBXO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO11 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO11 Gene COMPARTMENTS Subcellular localization image for FBXO11 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBXO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with FBXO11: view

Pathways for FBXO11 Gene

SuperPathways for FBXO11 Gene

Superpath Contained pathways
1 p53 pathway
genes like me logo Genes that share pathways with FBXO11: view

Pathways by source for FBXO11 Gene

1 BioSystems pathway for FBXO11 Gene

UniProtKB/Swiss-Prot Q86XK2-FBX11_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA 16487488
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531037
GO:0007605 sensory perception of sound IEA --
GO:0016567 protein ubiquitination NAS 10531035
GO:0035246 peptidyl-arginine N-methylation IDA 16487488
genes like me logo Genes that share ontologies with FBXO11: view

Transcripts for FBXO11 Gene

Unigene Clusters for FBXO11 Gene

F-box protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO11 Gene

No ASD Table

Relevant External Links for FBXO11 Gene

GeneLoc Exon Structure for
FBXO11
ECgene alternative splicing isoforms for
FBXO11

Expression for FBXO11 Gene

mRNA expression in normal human tissues for FBXO11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXO11 Gene

SOURCE GeneReport for Unigene cluster for FBXO11 Gene Hs.352677

mRNA Expression by UniProt/SwissProt for FBXO11 Gene

Q86XK2-FBX11_HUMAN
Tissue specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
genes like me logo Genes that share expressions with FBXO11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FBXO11 Gene

Orthologs for FBXO11 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXO11 35
  • 99.8 (n)
  • 100 (a)
FBXO11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXO11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO11 35
  • 97.39 (n)
  • 99.76 (a)
FBXO11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo11 35
  • 93.5 (n)
  • 99.53 (a)
Fbxo11 16
Fbxo11 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXO11 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXO11 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo11 35
  • 93.16 (n)
  • 99.88 (a)
chicken
(Gallus gallus)
Aves FBXO11 35
  • 88.44 (n)
  • 99.29 (a)
FBXO11 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXO11 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3356 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo11 35
  • 84.66 (n)
  • 97.09 (a)
Str.7451 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4555 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13073 35
fbxo11-like 35
  • 80.12 (n)
  • 98.02 (a)
fbxo11a 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001731 35
  • 62.13 (n)
  • 74.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta FBX011 35
  • 64.64 (n)
  • 74.39 (a)
FBX011 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea BE0003N10.3 36
  • 27 (a)
ManyToMany
dre-1 35
  • 60.41 (n)
  • 60.98 (a)
dre-1 36
  • 51 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
OneToMany
Species with no ortholog for FBXO11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO11 Gene

ENSEMBL:
Gene Tree for FBXO11 (if available)
TreeFam:
Gene Tree for FBXO11 (if available)

Paralogs for FBXO11 Gene

Paralogs for FBXO11 Gene

Selected SIMAP similar genes for FBXO11 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FBXO11: view

Variants for FBXO11 Gene

Sequence variations from dbSNP and Humsavar for FBXO11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs330787 -- 47,814,238(-) attga(C/T)gcgac intron-variant
rs874869 -- 47,867,198(+) ATCCC(C/G)AAAAT intron-variant
rs957443 -- 47,854,699(-) aatca(A/G)aaatt intron-variant
rs960106 -- 47,851,699(+) TCATA(C/T)GCACA intron-variant
rs1134354 -- 47,887,785(-) ctccc(A/G)ggctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO11 Gene

Variant ID Type Subtype PubMed ID
nsv519831 CNV Gain 19592680
nsv523013 CNV Loss 19592680
nsv874000 CNV Gain 21882294
esv2674438 CNV Deletion 23128226
esv2671167 CNV Deletion 23128226
esv2720030 CNV Deletion 23290073
esv2720031 CNV Deletion 23290073
esv2720032 CNV Deletion 23290073

Relevant External Links for FBXO11 Gene

HapMap Linkage Disequilibrium report
FBXO11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO11 Gene

Disorders for FBXO11 Gene

UniProtKB/Swiss-Prot

FBX11_HUMAN
  • Note=Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas. {ECO:0000269 PubMed:22113614}.

(2) University of Copenhagen DISEASES for FBXO11 Gene

Relevant External Links for FBXO11

Genetic Association Database (GAD)
FBXO11
Human Genome Epidemiology (HuGE) Navigator
FBXO11
genes like me logo Genes that share disorders with FBXO11: view

Publications for FBXO11 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. (PMID: 16487488) Cook J.R. … Pestka S. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  3. Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. (PMID: 16847180) Segade F. … Bowden D.W. (Arch. Otolaryngol. Head Neck Surg. 2006) 3 48
  4. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. (PMID: 17098746) Abida W.M. … Gu W. (J. Biol. Chem. 2007) 3 4
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 3 4

Products for FBXO11 Gene

Sources for FBXO11 Gene

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