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FBXO11 Gene

protein-coding   GIFtS: 56
GCID: GC02M048016

F-Box Protein 11

(Previous name: F-box only protein 11)
  See FBXO11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box Protein 111 2     Protein Arginine N-Methyltransferase 92 3
FBX112 3 5     Vitiligo-Associated Protein 12 3
PRMT92 3 5     UBR62
VIT12 3 5     Vitiligo-Associated Protein VIT-12
F-Box Only Protein 111 2     VIT-13
Ubiquitin Protein Ligase E3 Component N-Recognin 61 2     

External Ids:    HGNC: 135901   Entrez Gene: 802042   Ensembl: ENSG000001380817   OMIM: 6078715   UniProtKB: Q86XK23   

Export aliases for FBXO11 gene to outside databases

Previous GC identifers: GC02U990127 GC02M048202 GC02M047991 GC02M048008 GC02M047945 GC02M047869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXO11 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically
dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads
to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with
vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic
otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of
the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jun 2010)

GeneCards Summary for FBXO11 Gene:
FBXO11 (F-box protein 11) is a protein-coding gene. Diseases associated with FBXO11 include fetal hydantoin syndrome, and vitiligo. GO annotations related to this gene include protein-arginine N-methyltransferase activity and ubiquitin-protein ligase activity. An important paralog of this gene is FBXO10.

UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and
BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the
germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex
also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling,
cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated
p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53

Gene Wiki entry for FBXO11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO11 gene promoter:
         RFX1   AML1a   p53   HSF1short   HSF1 (long)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO11 promoter sequence
   Search Chromatin IP Primers for FBXO11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p16.3

FBXO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M048016:  view genomic region     (about GC identifiers)

Start:
48,016,455 bp from pter      End:
48,132,932 bp from pter
Size:
116,478 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2 (See protein sequence)
Recommended Name: F-box only protein 11  
Size: 927 amino acids; 103585 Da
Subunit: Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53,
BCL6 and DTL (when not phosphorylated)
Developmental stage: Protein levels increase during G1 and S phases to decline as cells progress through G2 to
enter in G1 phase of the next cell cycle
Caution: Isoform 2: Has been reported to act as an arginine methyltransferase that can catalyze the formation of
omega-N monomethylarginine (MMA) as well as symmetrical and asymmetrical dimethylarginine (sDMA and aDMA),
however no further works support these observations (PubMed:16487488)
Sequence caution: Sequence=AAF76888.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAN76518.1;
Type=Frameshift; Positions=141; Sequence=AAY24083.1; Type=Erroneous gene model prediction; Sequence=BAB15143.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1L491 Q52ZP1 Q53EP7 Q53RT5 Q8IXG3 Q96E90 Q9H6V8 Q9H9L1 Q9NR14 Q9UFK1
Q9UHI1 Q9UKC2
Alternative splicing: 6 isoforms:  Q86XK2-1   Q86XK2-2   Q86XK2-6   Q86XK2-3   Q86XK2-4   Q86XK2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO11: NX_Q86XK2

Explore proteomics data for FBXO11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys197
  • Modification sites at PhosphoSitePlus

  • See FBXO11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177203.1  NP_079409.3  

    ENSEMBL proteins: 
     ENSP00000402692   ENSP00000385127   ENSP00000385398   ENSP00000384823   ENSP00000428118  
     ENSP00000392272   ENSP00000323822   ENSP00000397359   ENSP00000367565  

    FBXO11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FBXO11
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    Novus Biologicals FBXO11 Protein
    Novus Biologicals FBXO11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO11

     
    Search eBioscience for Proteins for FBXO11 

     
    antibodies-online proteins for FBXO11 (2 products) 

     
    antibodies-online peptides for FBXO11

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    antibodies-online antibodies for FBXO11 (60 products) 

    FBXO11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for FBXO11 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBR: Ubiquitin protein ligase E3 component n-recognins
    FBXO: F-boxes / "other"

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT9
    Protein arginine N-methyltransferases

    Selected InterPro protein domains (see all 7):
     IPR012334 Pectin_lyas_fold
     IPR006633 Carb-bd_sugar_hydrolysis-dom
     IPR022441 Para_beta_helix_rpt-2
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q86XK2

    ProtoNet protein and cluster: Q86XK2

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Similarity: Contains 1 F-box domain
    Similarity: Contains 19 PbH1 repeats
    Similarity: Contains 1 UBR-type zinc finger


    Find genes that share domains with FBXO11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX11_HUMAN, Q86XK2
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and
    BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the
    germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex
    also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling,
    cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated
    p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI17098746
    GO:0008270zinc ion binding IEA--
    GO:0016274protein-arginine N-methyltransferase activity IDA16487488
         
    Find genes that share ontologies with FBXO11           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FBXO11:
     Increased cell death HMECs cel  Increased cilium length after   Increased gamma-H2AX phosphory  Increased viability with TRAIL 

         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fbxo11) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  other  skeleton 

    Find genes that share phenotypes with FBXO11           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FBXO11

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXO11:
    hsa-mir-21-5p (MIRT031059), hsa-mir-26b-5p (MIRT030357), hsa-mir-421 (MIRT039392), hsa-mir-101-3p (MIRT027332), hsa-mir-181a-5p (MIRT025191)

    Block miRNA regulation of human, mouse, rat FBXO11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO11 (see all 100):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-376b hsa-miR-1244 hsa-miR-298 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidFBXO11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO11
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO11

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FBXO11

    Clone
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    OriGene clones in human, mouse for FBXO11 (see all 14)
    OriGene ORF clones in mouse, rat for FBXO11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO11 (NM_025133)
    Sino Biological Human cDNA Clone for FBXO11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO11

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO11 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBX11_HUMAN, Q86XK2: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with FBXO11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXO11 About    
    See pathways by source

    SuperPathContained pathways About
    1p53 pathway
    p53 pathway


    1 BioSystems Pathway for FBXO11
        p53 pathway



    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO11: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXO11 (Q86XK21, 3 ENSP000003238224) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-1047804,EBI-307486 I2D: score=2 STRING: ENSP00000231487
    TP53P046371, 3, ENSP000002693054EBI-1047804,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    BTBD9Q96Q073, ENSP000003861214I2D: score=5 STRING: ENSP00000386121
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IDA16487488
    GO:0006511ubiquitin-dependent protein catabolic process NAS10531037
    GO:0007605sensory perception of sound IEA--
    GO:0016567protein ubiquitination NAS10531035
    GO:0035246peptidyl-arginine N-methylation IDA16487488

    Find genes that share ontologies with FBXO11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO11 (FBX11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXO11 gene (4 alternative transcripts): 
    NM_001190274.1  NM_025133.4  NM_012167.1  NM_018693.2  

    Unigene Cluster for FBXO11:

    F-box protein 11
    Hs.352677  [show with all ESTs]
    Unigene Representative Sequence: NM_001190274
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434234 ENST00000405808 ENST00000465204 ENST00000402508(uc010fbk.3 uc010fbl.3)
    ENST00000403359(uc002rwe.3) ENST00000470899 ENST00000493962(uc021vhe.1)
    ENST00000492225(uc002rwg.2) ENST00000424163 ENST00000480038 ENST00000316377
    ENST00000434523 ENST00000378314
    miRNA
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    Block miRNA regulation of human, mouse, rat FBXO11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO11 (see all 100):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-376b hsa-miR-1244 hsa-miR-298 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidFBXO11 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXO11 (NM_025133)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO11
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXO11
      QuantiFast Probe-based Assays in human, mouse, rat FBXO11

    Additional mRNA sequence: 

    AF174599.1 AF176706.1 AF351618.1 AK022735.1 AK025477.1 AK097734.1 AK223592.1 AK292877.1 
    AK297444.1 AK304140.1 AK315108.1 AL117620.1 AY827075.1 BC012728.2 BC043258.1 BC130445.1 
    BC136480.1 

    20 DOTS entries:

    DT.450978  DT.91759465  DT.95369393  DT.100798410  DT.95229383  DT.101984596  DT.95229340  DT.95369389 
    DT.100798415  DT.120935269  DT.100798411  DT.100798412  DT.100798424  DT.120935181  DT.120935284  DT.91759467 
    DT.95369390  DT.97860069  DT.100798414  DT.121142064 

    Selected AceView cDNA sequences (see all 255):

    BQ772249 BQ423322 AL121091 AL044521 AI633439 AI357062 CN483663 N59161 
    AA370623 AW967541 BM713483 AW262587 NM_025133 AI769225 AA424096 BC012728 
    AW513123 CA393206 AW991247 BU675819 BE349859 BM454509 BQ772044 AF176706 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXO11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCATAACA
    FBXO11 Expression
    About this image

    FBXO11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352677

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Tissue specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXO11: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO11
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    QuantiFast Probe-based Assays in human, mouse, rat FBXO11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXO11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo111 , 5 F-box protein 111, 5 93.5(n)1
    99.53(a)1
      17 (57.87 cM)5
    2250551  NM_001081034.11  NP_001074503.11 
     879908595 
    chicken
    (Gallus gallus)
    Aves FBXO111 F-box protein 11 88.44(n)
    99.29(a)
      421289  XM_004940198.1  XP_004940255.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO116
    F-box protein 11
    95(a)
    1 ↔ 1
    1(255206463-255298181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33562 Xenopus laevis transcribed sequence with moderate similarity more 81.64(n)    BU917012.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130732 Transcribed sequence with weak similarity to protein more 78.68(n)    57069785 
    fruit fly
    (Drosophila melanogaster)
    Insecta FBX0111 FBX011 ortholog 64.64(n)
    74.39(a)
      41209  NM_001275512.1  NP_001262441.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dre-11 dre-1 60.41(n)
    60.98(a)
      179045  NM_072260.5  NP_504661.1 


    ENSEMBL Gene Tree for FBXO11 (if available)
    TreeFam Gene Tree for FBXO11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXO11 gene
    FBXO102  
    3 SIMAP similar genes for FBXO11 using alignment to 8 protein entries:     FBX11_HUMAN (see all proteins):
    FBXO15    FBXO8    UBR5

    Find genes that share paralogs with FBXO11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FBXO11 (see all 2449)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470673671,2
    C--47771247(+) CATGAC/GATTAA 2 -- ut310--------
    rs1996223021,2
    --47771301(+) AAAAA-/TCAAAA 2 -- ut310--------
    rs31363711,2
    C,F,H--47771469(+) GTTGGT/CATCTG 2 -- ut3120Minor allele frequency- C:0.01NS EA NA CSA WA 2066
    rs1891728431,2
    --47771563(+) GAGTCA/GATATA 2 -- ut310--------
    rs37321871,2
    H--47771578(+) CACTTT/CCTTTT 2 -- ut31 trp34Minor allele frequency- C:0.00NS EA 420
    rs1383716331,2
    --47771617(+) GACCTC/TGTGTA 2 -- ut310--------
    rs37321881,2
    C,F,H--47771619(+) CCTTGT/GGTATC 2 -- ut31 ese35Minor allele frequency- G:0.01NS EA 540
    rs2018549811,2
    C--47771699(+) AGTTAC/TGATGT 2 -- ut310--------
    rs2011604611,2
    --47771711(+) ACAATA/GGCAGG 2 -- ut310--------
    rs1818280691,2
    C--47771715(+) TGGCAA/GGACTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXO11 (48016455 - 48132932 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXO11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720032CNV Deletion23290073
    esv2674438CNV Deletion23128226
    esv2720030CNV Deletion23290073
    esv2671167CNV Deletion23128226
    esv2720031CNV Deletion23290073
    nsv523013CNV Loss19592680
    nsv874000CNV Gain21882294
    nsv519831CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO11
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607871    OMIM disorders: --

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
  • Note=Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of
    BCL6, an oncoprotein that has a critical role in lymphomas (PubMed:22113614)

  • 2 diseases for FBXO11:    
    About MalaCards
    fetal hydantoin syndrome    vitiligo

    2 diseases from the University of Copenhagen DISEASES database for FBXO11:
    Vitiligo     Otitis media

    Find genes that share disorders with FBXO11           About GenesLikeMe

    Genetic Association Database (GAD): FBXO11
    Human Genome Epidemiology (HuGE) Navigator: FBXO11 (4 documents)

    Export disorders for FBXO11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXO11 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with FBXO11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. (PubMed id 16487488)1, 2, 3 Cook J.R....Pestka S. (Biochem. Biophys. Res. Commun. 2006)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    3. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. (PubMed id 23478441)1, 2 Rossi M....Pagano M. (Mol. Cell 2013)
    4. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. (PubMed id 23478445)1, 2 Abbas T....Dutta A. (Mol. Cell 2013)
    5. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. (PubMed id 22113614)1, 2 Duan S....Pagano M. (Nature 2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. (PubMed id 17098746)1, 2 Abida W.M.... Gu W. (J. Biol. Chem. 2007)
    8. Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. (PubMed id 16847180)1, 4 Segade F....Bowden D.W. (amp 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 80204 HGNC: 13590 AceView: FBXO11 Ensembl:ENSG00000138081 euGenes: HUgn80204
    ECgene: FBXO11 H-InvDB: FBXO11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FBXO11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FBXO11 gene:
    Search GeneIP for patents involving FBXO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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