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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO11 Gene

protein-coding   GIFtS: 50
GCID: GC02M048016

F-box protein 11

(Previous name: F-box only protein 11 )
 Explore 7 diseases affiliated with
FBXO11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FBXO11    

Aliases
for FBXO11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
F-Box Protein 111 2     Vitiligo-Associated Protein 12 3
FBX111 2 3 5     Protein Arginine N-Methyltransferase 92
PRMT91 2 5     Ubiquitin Protein Ligase E3 Component N-Recognin 62
VIT12 3 5     Vitiligo-Associated Protein VIT-12
UBR61 2     VIT-13
F-Box Only Protein 111 2     

External Ids:    HGNC: 135901   Entrez Gene: 802042   Ensembl: ENSG000001380817   OMIM: 6078715   UniProtKB: Q86XK23   

Export aliases for FBXO11 gene to outside databases

Previous GC identifers: GC02U990127 GC02M048202 GC02M047991 GC02M048008 GC02M047945 GC02M047869


Summaries
for FBXO11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FBXO11:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs
class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts
as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is
known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation.
Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media
(COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant
Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms
have been identified for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
Function: Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds
to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional
activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53

Gene Wiki entry for FBXO11


Genomic Views
for FBXO11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO11 gene promoter:
         RFX1   AML1a   p53   HSF1short   HSF1 (long)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBXO11 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p16.3

FBXO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M048016:  view genomic region     (about GC identifiers)

Start:
 48,016,455 bp from pter      End:
 48,132,932 bp from pter
Size:
 116,478 bases      Orientation:
 minus strand

Proteins
for FBXO11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2 (See protein sequence)
Recommended Name: F-box only protein 11  
Size: 927 amino acids; 103585 Da
Subunit: Component of the probable SCF(FBXWO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with TP53
Subcellular location: Nucleus
Sequence caution: Sequence=AAF76888.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAN76518.1;
Type=Frameshift; Positions=141; Sequence=AAY24083.1; Type=Erroneous gene model prediction; Sequence=BAB15143.1;
Type=Erroneous initiation;
Secondary accessions: A1L491 Q52ZP1 Q53EP7 Q53RT5 Q8IXG3 Q96E90 Q9H6V8 Q9H9L1 Q9NR14 Q9UFK1 Q9UHI1
Q9UKC2
Alternative splicing: 6 isoforms:  Q86XK2-1   Q86XK2-2   Q86XK2-6   Q86XK2-3   Q86XK2-4   Q86XK2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO11: NX_Q86XK2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86XK2

    • FBXO11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177203.1  NP_079409.3  

    ENSEMBL proteins: 
     ENSP00000402692   ENSP00000385127   ENSP00000385398   ENSP00000384823   ENSP00000428118  
     ENSP00000392272   ENSP00000323822   ENSP00000397359   ENSP00000367565  

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    Novus Biologicals FBXO11 Protein
    Novus Biologicals FBXO11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBXO11

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531037
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--


    FBXO11 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FBXO11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FBXO11 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR012334 Pectin_lyas_fold
     IPR006633 Carb-bd_sugar_hydrolysis-dom
     IPR022441 Para_beta_helix_rpt-2
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q86XK2

    ProtoNet protein and cluster: Q86XK2

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Similarity: Contains 1 F-box domain
    Similarity: Contains 19 PbH1 repeats
    Similarity: Contains 1 UBR-type zinc finger


    Function
    for FBXO11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Function: Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds
    to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional
    activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53

    miRNA
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    hsa-miR-576-3p hsa-miR-520e hsa-miR-376b hsa-miR-1244 hsa-miR-298 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-520b
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0016274protein-arginine N-methyltransferase activity IDA16487488


    FBXO11 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for FBXO11:
     Increased cell death HMECs cel  Increased cilium length after   Increased gamma-H2AX phosphory  Increased viability with TRAIL 

    Animal Models:
         15/16 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fbxo11) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  other  skeleton 

    FBXO11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FBXO11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1p53 pathway
    		p53 pathway1.00


    1 BioSystems Pathway for FBXO11 
        p53 pathway


    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for FBXO11 (Q86XK21, 3 ENSP000003238224) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-1047804,EBI-307486 I2D: score=2 STRING: ENSP00000231487
    TP53P046371, 3, ENSP000002693054EBI-1047804,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    BTBD9Q96Q073, ENSP000003861214I2D: score=5 STRING: ENSP00000386121
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IDA16487488
    GO:0006511ubiquitin-dependent protein catabolic process NAS10531037
    GO:0007605sensory perception of sound IEA--
    GO:0016567protein ubiquitination NAS10531035
    GO:0035246peptidyl-arginine N-methylation IDA16487488


    FBXO11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FBXO11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO11
    Search CenterWatch for drugs/clinical trials and news about FBXO11 / FBX11 

    Transcripts
    for FBXO11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FBXO11 gene (4 alternative transcripts): 
    NM_001190274.1  NM_025133.4  NM_012167.1  NM_018693.2  

    Unigene Cluster for FBXO11:

    F-box protein 11
    Hs.352677  [show with all ESTs]
    Unigene Representative Sequence: NM_001190274
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434234 ENST00000405808 ENST00000465204 ENST00000402508(uc010fbk.3 uc010fbl.3)
    ENST00000403359(uc002rwe.3) ENST00000470899 ENST00000493962(uc021vhe.1)
    ENST00000492225(uc002rwg.2) ENST00000424163 ENST00000480038 ENST00000316377
    ENST00000434523 ENST00000378314

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    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO11 (see all 100):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-376b hsa-miR-1244 hsa-miR-298 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmid: FBXO11 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF174599.1 AF176706.1 AF351618.1 AK022735.1 AK025477.1 AK097734.1 AK223592.1 AK292877.1 
    AK297444.1 AK304140.1 AK315108.1 AL117620.1 AY827075.1 BC012728.2 BC043258.1 BC130445.1 
    BC136480.1 

    20 DOTS entries:

    DT.450978  DT.91759465  DT.95369393  DT.100798410  DT.95229383  DT.101984596  DT.95229340  DT.95369389 
    DT.100798415  DT.120935269  DT.100798411  DT.100798412  DT.100798424  DT.120935181  DT.120935284  DT.91759467 
    DT.95369390  DT.97860069  DT.100798414  DT.121142064 

    24/255 AceView cDNA sequences (see all 255):

    AW196584 CN483663 N59161 AI633439 AW611884 AI610797 BE349859 NM_018693 
    BU675819 BQ421483 AI357062 AA353463 BM782277 BU183731 AL121091 AA487967 
    BQ423322 BM713483 BU429665 BG059588 AI769225 BQ776312 BM454509 AI826749 

    GeneLoc Exon Structure


    Expression
    for FBXO11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACCATAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FBXO11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO11

    SOURCE GeneReport for Unigene cluster: Hs.352677

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Tissue specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO11: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for FBXO11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FBXO11 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FBXO111 F-box protein 11 84.67(n)
    93.71(a)    		   421289  XM_419357.3  XP_419357.2 
    lizard
    (Anolis carolinensis)    		 Reptilia FBXO116
    		 --
    		 99(a)
    		 1 ↔ 1
    		 1(255206463-255240578)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.33562 Xenopus laevis transcribed sequence with moderate similarity more 81.64(n)    BU917012.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.130732 Transcribed sequence with weak similarity to protein more 78.68(n)    57069785 
    fruit fly
    (Drosophila melanogaster)    		 Insecta FBX0111 FBX011 ortholog 64.64(n)
    74.39(a)    		   41209  NM_141697.1  NP_649954.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dre-11 Protein DRE-1 57.55(n)
    56.07(a)    		   179045  NM_072260.4  NP_504661.1 


    ENSEMBL Gene Tree for FBXO11 (if available)
    TreeFam Gene Tree for FBXO11 (if available) 

    Paralogs
    for FBXO11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO11 gene
    FBXO102  
    3 SIMAP similar genes for FBXO11 using alignment to 8 protein entries:     FBX11_HUMAN (see all proteins):
    FBXO15    FBXO8    UBR5

    FBXO11 for paralogs           About GeneDecksing



    Genomic Variants
    for FBXO11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1910 NCBI SNPs in FBXO11 are shown (see all 1910)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs31363711,2
    		C,F,H,--47771469(+) GTTGGT/CATCTG 2 -- ut3120Minor allele frequency- C:0.01NS EA NA CSA WA 2066
    rs37321871,2
    		H--47771578(+) CACTTT/CCTTTT 2 -- ut31 trp34Minor allele frequency- C:0.00NS EA 420
    rs37321881,2
    		C,F,H,--47771619(+) CCTTGT/GGTATC 2 -- ut31 ese35Minor allele frequency- G:0.01NS EA 540
    rs31363721,2
    		F--47772115(+) CTGTTTATAT/- 
                ATTAC     		2 -- int11Minor allele frequency- -:0.02NS 176
    rs170369691,2
    		C,F,H,--47772300(+) CCTCTC/GAAATG 2 -- int17Minor allele frequency- G:0.02NA EA NS CSA 414
    rs788880361,2
    		C,F,--47772305(+) CAAATG/CTTTCT 2 -- int13Minor allele frequency- C:0.08CSA WA NA 242
    rs1119335071,2
    		--47772356(+) GTCACG/AGTGAC 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs170369711,2
    		C,F,--47772475(+) TTCCAT/GAGTTA 2 -- int16Minor allele frequency- G:0.06NA CSA WA 384
    rs67172841,2
    		C,F,A,--47772481(+) AGTTAT/CGGTCt 2 -- int11Minor allele frequency- C:0.03WA 118
    rs751758861,2
    		--47773165(+) CTTCTA/GATTAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for FBXO11 (48016455 - 48132932 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FBXO11: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXO11
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    Disorders / Diseases
    for FBXO11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FBXO11 for disorders           About GeneDecksing

    OMIM gene information: 607871    OMIM disorders: --

    7 diseases for FBXO11:    About MalaCards
    otitis media    vitiligo    diffuse large b-cell lymphoma    b-cell lymphomas
    hearing loss    conjunctivitis    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for FBXO11:
    Vitiligo     Otitis media
    Human Genome Epidemiology (HuGE) Navigator: FBXO11 (4 documents)

    Export disorders for FBXO11 gene to outside databases

    Publications
    for FBXO11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO11 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with FBXO11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. (PubMed id 17098746)1, 2 Abida W.M.... Gu W. (2007)
    3. FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. (PubMed id 16487488)1, 3 Cook J.R....Pestka S. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. 'VIT1', a novel gene associated with vitiligo. (PubMed id 11775060)1, 2 Le Poole I.C.... Boissy R.E. (2001)
    7. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
    8. The role of VIT1/FBXO11 in the regulation of apoptosi s and tyrosinase export from endoplasmic reticulum in cultured melanocytes. (PubMed id 20514423)1, 9 Guan C....Xu A. (2010)
    9. VIT1/FBXO11 knockdown induces morphological alterations and apoptosis in B10BR mouse melanocytes. (PubMed id 19360327)1, 9 Li Y....Xu A. (2009)
    10. FBXO11 targets BCL6 for degradation and is inactivate d in diffuse large B-cell lymphomas. (PubMed id 22113614)1 Duan S....Pagano M. (2012)

    External Searches for FBXO11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FBXO11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80204 HGNC: 13590 AceView: FBXO11 Ensembl:ENSG00000138081 euGenes: HUgn80204
    ECgene: FBXO11 H-InvDB: FBXO11

    Other Databases showing FBXO11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FBXO11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FBXO11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FBXO11 gene:
    Search GeneIP for patents involving FBXO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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