Free for academic non-profit institutions. Other users need a Commercial license

FBXO11 Gene(Protein Coding)

F-Box Protein 11

GCID:
GC02M047789
GIFtS:
54
Genes Participants
UDN Logo

Aliases for FBXO11 Gene

Aliases for FBXO11 Gene

  • F-Box Protein 11 2 3 5
  • Ubiquitin Protein Ligase E3 Component N-Recognin 6 2 3
  • Protein Arginine N-Methyltransferase 9 3 4
  • Vitiligo-Associated Protein 1 3 4
  • F-Box Only Protein 11 2 3
  • FBX11 3 4
  • PRMT9 3 4
  • VIT1 3 4
  • Vitiligo-Associated Protein VIT-1 3
  • UG063H01 3
  • VIT-1 4
  • UBR6 3

External Ids for FBXO11 Gene

Previous GeneCards Identifiers for FBXO11 Gene

  • GC02U990127
  • GC02M048202
  • GC02M047991
  • GC02M048008
  • GC02M047945
  • GC02M047869
  • GC02M048016

Summaries for FBXO11 Gene

Entrez Gene Summary for FBXO11 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for FBXO11 Gene

FBXO11 (F-Box Protein 11) is a Protein Coding gene. Diseases associated with FBXO11 include Otitis Media and Middle Ear Disease. Among its related pathways are p53 pathway (Pathway Interaction Database). GO annotations related to this gene include ubiquitin-protein transferase activity and protein-arginine N-methyltransferase activity. An important paralog of this gene is FBXO10.

UniProtKB/Swiss-Prot for FBXO11 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Gene Wiki entry for FBXO11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO11 Gene

Genomics for FBXO11 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO11 Gene

Enhancers for FBXO11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G048105 1.3 Ensembl ENCODE 12.2 -200.6 -200622 2.7 FOXA2 ATF1 MLX ARNT ZFP64 ARID4B SIN3A ZNF48 YY1 TCF12 FBXO11 LOC100506235 FOXN2 PPP1R21 RNU6-282P GC02P048073 GC02P048218
GH02G048332 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -425.9 -425941 0.4 PKNOX1 MTA2 DPF2 TBX21 RFX5 NFIC RELB HOMEZ EZH2 SPI1 PPP1R21 FBXO11 LOC100506235 FOXN2 RNU4-49P GC02M048341 GC02P048318
GH02G048447 1.5 Ensembl ENCODE dbSUPER 9.6 -543.7 -543655 4.4 FOXA2 PKNOX1 ATF1 YY1 TCF12 GATA2 PPARG MIER3 SMARCA4 RCOR2 RNU6-282P STON1 STON1-GTF2A1L FBXO11 LOC100506235 PPP1R21 GC02M048449 PIR50991 GC02M048450
GH02G048145 1.6 FANTOM5 Ensembl ENCODE 6.1 -239.7 -239721 1.5 PKNOX1 ATF1 CREB3L1 ZNF766 CBX5 GATA2 KLF13 SP5 GTF2B ZNF518A PPP1R21 FBXO11 FOXN2 GC02P048073 GC02P048218
GH02G047866 0.8 Ensembl ENCODE 12.1 +38.7 38687 2.5 NFIC JUND JUN FOS NR2F2 FBXO11 LOC100506235 PPP1R21 MSH6 GC02P047850 RPS27AP7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO11 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000116872 935 4001 HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 YY1 CBX5

Transcription factor binding sites by QIAGEN in the FBXO11 gene promoter:

Genomic Location for FBXO11 Gene

Chromosome:
2
Start:
47,789,316 bp from pter
End:
47,906,535 bp from pter
Size:
117,220 bases
Orientation:
Minus strand

Genomic View for FBXO11 Gene

Genes around FBXO11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO11 Gene

Proteins for FBXO11 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBXO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XK2-FBX11_HUMAN
    Recommended name:
    F-box only protein 11
    Protein Accession:
    Q86XK2
    Secondary Accessions:
    • A1L491
    • Q52ZP1
    • Q53EP7
    • Q53RT5
    • Q8IXG3
    • Q96E90
    • Q9H6V8
    • Q9H9L1
    • Q9NR14
    • Q9UFK1
    • Q9UHI1
    • Q9UKC2

    Protein attributes for FBXO11 Gene

    Size:
    927 amino acids
    Molecular mass:
    103585 Da
    Quaternary structure:
    • Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1.
    SequenceCaution:
    • Sequence=AAF76888.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAN76518.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305}; Sequence=AAY24083.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15143.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO11 Gene

Protein Expression for FBXO11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO11 Gene

  • Ubiquitination at isoforms=3, 5, 6197
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXO11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO11 Gene

Domains & Families for FBXO11 Gene

No data available for UniProtKB/Swiss-Prot for FBXO11 Gene

Function for FBXO11 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO11 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.

Gene Ontology (GO) - Molecular Function for FBXO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS,TAS --
GO:0005515 protein binding IPI 17098746
GO:0008270 zinc ion binding IEA --
GO:0016274 protein-arginine N-methyltransferase activity IDA 16487488
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FBXO11: view
genes like me logo Genes that share phenotypes with FBXO11: view

Animal Models for FBXO11 Gene

MGI Knock Outs for FBXO11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXO11 Gene

Localization for FBXO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO11 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO11 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FBXO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus IDA 16487488
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 16487488
genes like me logo Genes that share ontologies with FBXO11: view

Pathways & Interactions for FBXO11 Gene

SuperPathways for FBXO11 Gene

PathCards logo More details on SuperPathways for FBXO11
SuperPathway Contained pathways
1 p53 pathway (Pathway Interaction Database)
p53 pathway
-
genes like me logo Genes that share pathways with FBXO11: view

Pathways by source for FBXO11 Gene

1 BioSystems pathway for FBXO11 Gene

UniProtKB/Swiss-Prot Q86XK2-FBX11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for FBXO11 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FBXO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006464 cellular protein modification process IDA 16487488
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531037
GO:0007605 sensory perception of sound IEA --
GO:0016567 protein ubiquitination NAS,IEA 10531035
genes like me logo Genes that share ontologies with FBXO11: view

Drugs & Compounds for FBXO11 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FBXO11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO11 Gene

(9) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(255) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO11 Gene

F-box protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO11 Gene

No ASD Table

Relevant External Links for FBXO11 Gene

GeneLoc Exon Structure for
FBXO11
ECgene alternative splicing isoforms for
FBXO11

Expression for FBXO11 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO11 Gene

mRNA expression in normal human tissues for FBXO11 Gene
mRNA expression by BioGPS for FBXO11 GenemRNA expression by GTEx for FBXO11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXO11 Gene

This gene is overexpressed in Platelet (57.4) and Fetal Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXO11 Gene



Protein tissue co-expression partners for FBXO11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXO11 Gene:

FBXO11

SOURCE GeneReport for Unigene cluster for FBXO11 Gene:

Hs.352677

mRNA Expression by UniProt/SwissProt for FBXO11 Gene:

Q86XK2-FBX11_HUMAN
Tissue specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.

Evidence on tissue expression from TISSUES for FBXO11 Gene

  • Nervous system(4.8)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with FBXO11: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO11 Gene

Orthologs for FBXO11 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO11 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
 Mammalia FBXO11 35
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia FBXO11 34 35
  • 99.8 (n)
cow
(Bos Taurus)
 Mammalia FBXO11 35
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FBXO11 34 35
  • 97.39 (n)
mouse
(Mus musculus)
 Mammalia Fbxo11 34 16 35
  • 93.5 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo11 34
  • 93.16 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia FBXO11 35
  • 91 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FBXO11 34 35
  • 88.44 (n)
lizard
(Anolis carolinensis)
 Reptilia FBXO11 35
  • 95 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo11 34
  • 84.66 (n)
Str.7451 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.3356 34
zebrafish
(Danio rerio)
 Actinopterygii fbxo11a 35
  • 92 (a)
 OneToOne
fbxo11-like 34
  • 80.12 (n)
Dr.13073 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4555 34
fruit fly
(Drosophila melanogaster)
 Insecta FBX011 34 35
  • 64.64 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001731 34
  • 62.13 (n)
worm
(Caenorhabditis elegans)
 Secernentea dre-1 34 35
  • 60.41 (n)
BE0003N10.3 35
  • 27 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 74 (a)
 OneToMany
Species where no ortholog for FBXO11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO11 Gene

ENSEMBL:
Gene Tree for FBXO11 (if available)
TreeFam:
Gene Tree for FBXO11 (if available)

Paralogs for FBXO11 Gene

Paralogs for FBXO11 Gene

(3) SIMAP similar genes for FBXO11 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FBXO11: view

Variants for FBXO11 Gene

Sequence variations from dbSNP and Humsavar for FBXO11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs267608094 Pathogenic 47,806,641(+) CACTA(C/T)GATTA downstream-variant-500B, reference, stop-gained
rs267608118 Pathogenic 47,806,454(+) AGGCA(-/A)TGCAT downstream-variant-500B, reference, frameshift-variant
rs267608120 Pathogenic 47,806,609(+) TAGAA(-/AAGC/CAAG/GCAA)AAGAG downstream-variant-500B, reference, frameshift-variant
rs267608121 Pathogenic 47,806,637(+) AGTCA(-/GTCA)CTACG downstream-variant-500B, reference, frameshift-variant
rs267608122 Pathogenic 47,806,651(+) ATTTC(A/C/G)GTAAC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FBXO11 Gene

Variant ID Type Subtype PubMed ID
esv2671167 CNV deletion 23128226
esv2674438 CNV deletion 23128226
esv2720030 CNV deletion 23290073
esv2720031 CNV deletion 23290073
esv2720032 CNV deletion 23290073
esv3583784 CNV loss 25503493
esv3583785 CNV loss 25503493
esv3590641 CNV loss 21293372
nsv1072940 CNV deletion 25765185
nsv519831 CNV gain 19592680
nsv523013 CNV loss 19592680
nsv963230 CNV duplication 23825009
nsv979003 CNV duplication 23825009

Variation tolerance for FBXO11 Gene

Residual Variation Intolerance Score: 4.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO11 Gene

Human Gene Mutation Database (HGMD)
FBXO11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO11 Gene

Disorders for FBXO11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FBXO11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
otitis media
  • otitis media, susceptibility to
middle ear disease
  • disorder of middle ear
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FBX11_HUMAN
  • Note=Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas. {ECO:0000269 PubMed:22113614}.

Relevant External Links for FBXO11

Genetic Association Database (GAD)
FBXO11
Human Genome Epidemiology (HuGE) Navigator
FBXO11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO11
genes like me logo Genes that share disorders with FBXO11: view

No data available for Genatlas for FBXO11 Gene

Publications for FBXO11 Gene

  1. FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. (PMID: 16487488) Cook J.R. … Pestka S. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  3. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. (PMID: 23478441) Rossi M. … Pagano M. (Mol. Cell 2013) 3 4 64
  4. CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration. (PMID: 23478445) Abbas T. … Dutta A. (Mol. Cell 2013) 3 4 64
  5. Regulation of TGF-I^ signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. (PMID: 23892434) Abbas T. … Dutta A. (Cell Cycle 2013) 3 4 64

Products for FBXO11 Gene

Sources for FBXO11 Gene

Content
Loading form....