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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO11 Gene

protein-coding   GIFtS: 55
GCID: GC02M048016

F-Box Protein 11

(Previous name: F-box only protein 11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 111 2     PRMT92 5
FBX112 3 5     UBR62
VIT12 3 5     Protein Arginine N-Methyltransferase 92
F-Box Only Protein 111 2     Vitiligo-Associated Protein VIT-12
Ubiquitin Protein Ligase E3 Component N-Recognin 61 2     VIT-13
Vitiligo-Associated Protein 12 3     

External Ids:    HGNC: 135901   Entrez Gene: 802042   Ensembl: ENSG000001380817   OMIM: 6078715   UniProtKB: Q86XK23   

Export aliases for FBXO11 gene to outside databases

Previous GC identifers: GC02U990127 GC02M048202 GC02M047991 GC02M048008 GC02M047945 GC02M047869


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO11 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically
dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads
to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with
vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic
otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of
the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media.
Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Jun 2010)

GeneCards Summary for FBXO11 Gene: 
FBXO11 (F-box protein 11) is a protein-coding gene. Diseases associated with FBXO11 include otitis media, and vitiligo. GO annotations related to this gene include protein-arginine N-methyltransferase activity and ubiquitin-protein ligase activity. An important paralog of this gene is FBXO10.

UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
Function: Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its
transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53

Gene Wiki entry for FBXO11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO11 gene promoter:
         RFX1   AML1a   p53   HSF1short   HSF1 (long)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXO11 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXO11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.3   Ensembl cytogenetic band:  2p16.3   HGNC cytogenetic band: 2p16.3

FBXO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M048016:  view genomic region     (about GC identifiers)

Start:
48,016,455 bp from pter      End:
48,132,932 bp from pter
Size:
116,478 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2 (See protein sequence)
Recommended Name: F-box only protein 11  
Size: 927 amino acids; 103585 Da
Subunit: Component of the probable SCF(FBXWO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with
TP53
Subcellular location: Nucleus
Sequence caution: Sequence=AAF76888.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAN76518.1;
Type=Frameshift; Positions=141; Sequence=AAY24083.1; Type=Erroneous gene model prediction; Sequence=BAB15143.1;
Type=Erroneous initiation;
Secondary accessions: A1L491 Q52ZP1 Q53EP7 Q53RT5 Q8IXG3 Q96E90 Q9H6V8 Q9H9L1 Q9NR14 Q9UFK1
Q9UHI1 Q9UKC2
Alternative splicing: 6 isoforms:  Q86XK2-1   Q86XK2-2   Q86XK2-6   Q86XK2-3   Q86XK2-4   Q86XK2-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXO11: NX_Q86XK2

Explore proteomics data for FBXO11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86XK2

  • FBXO11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177203.1  NP_079409.3  

    ENSEMBL proteins: 
     ENSP00000402692   ENSP00000385127   ENSP00000385398   ENSP00000384823   ENSP00000428118  
     ENSP00000392272   ENSP00000323822   ENSP00000397359   ENSP00000367565  

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO11 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    FBXO11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBR: Ubiquitin protein ligase E3 component n-recognins
    FBXO: F-boxes / "other"
    PRMT: Protein arginine methyltransferases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PRMT9 
    Protein arginine N-methyltransferases

    5/7 InterPro protein domains (see all 7):
     IPR012334 Pectin_lyas_fold
     IPR006633 Carb-bd_sugar_hydrolysis-dom
     IPR022441 Para_beta_helix_rpt-2
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q86XK2

    ProtoNet protein and cluster: Q86XK2

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Similarity: Contains 1 F-box domain
    Similarity: Contains 19 PbH1 repeats
    Similarity: Contains 1 UBR-type zinc finger


    FBXO11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX11_HUMAN, Q86XK2
    Function: Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes
    and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its
    transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI17098746
    GO:0008270zinc ion binding IEA--
    GO:0016274protein-arginine N-methyltransferase activity IDA16487488
         
    FBXO11 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FBXO11:
     Increased cell death HMECs cel  Increased cilium length after   Increased gamma-H2AX phosphory  Increased viability with TRAIL 

         15/16 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Fbxo11) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  nervous system  other  skeleton 

    FBXO11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXO11 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO11 
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    SwitchGear 3'UTR luciferase reporter plasmidFBXO11 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXO11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p53 pathway
    p53 pathway


    1 BioSystems Pathway for FBXO11
        p53 pathway



    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for FBXO11 (Q86XK21, 3 ENSP000003238224) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632081, 3, ENSP000002314874EBI-1047804,EBI-307486 I2D: score=2 STRING: ENSP00000231487
    TP53P046371, 3, ENSP000002693054EBI-1047804,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    BTBD9Q96Q073, ENSP000003861214I2D: score=5 STRING: ENSP00000386121
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process IDA16487488
    GO:0006511ubiquitin-dependent protein catabolic process NAS10531037
    GO:0007605sensory perception of sound IEA--
    GO:0016567protein ubiquitination NAS10531035
    GO:0035246peptidyl-arginine N-methylation IDA16487488

    FBXO11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO11 (FBX11)

    Search CenterWatch for drugs/clinical trials and news about FBXO11 / FBX11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO11 gene (4 alternative transcripts): 
    NM_001190274.1  NM_025133.4  NM_012167.1  NM_018693.2  

    Unigene Cluster for FBXO11:

    F-box protein 11
    Hs.352677  [show with all ESTs]
    Unigene Representative Sequence: NM_001190274
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000434234 ENST00000405808 ENST00000465204 ENST00000402508(uc010fbk.3 uc010fbl.3)
    ENST00000403359(uc002rwe.3) ENST00000470899 ENST00000493962(uc021vhe.1)
    ENST00000492225(uc002rwg.2) ENST00000424163 ENST00000480038 ENST00000316377
    ENST00000434523 ENST00000378314
    miRNA
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    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO11 (see all 100):
    hsa-miR-576-3p hsa-miR-520e hsa-miR-376b hsa-miR-1244 hsa-miR-298 hsa-miR-508-5p hsa-miR-3613-3p hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidFBXO11 3' UTR sequence
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    Additional mRNA sequence: 

    AF174599.1 AF176706.1 AF351618.1 AK022735.1 AK025477.1 AK097734.1 AK223592.1 AK292877.1 
    AK297444.1 AK304140.1 AK315108.1 AL117620.1 AY827075.1 BC012728.2 BC043258.1 BC130445.1 
    BC136480.1 

    20 DOTS entries:

    DT.450978  DT.91759465  DT.95369393  DT.100798410  DT.95229383  DT.101984596  DT.95229340  DT.95369389 
    DT.100798415  DT.120935269  DT.100798411  DT.100798412  DT.100798424  DT.120935181  DT.120935284  DT.91759467 
    DT.95369390  DT.97860069  DT.100798414  DT.121142064 

    24/255 AceView cDNA sequences (see all 255):

    AW991247 BM754261 BQ772249 CA393206 AI754726 AI766651 AA424019 AA353463 
    AF176706 AA424096 AA487966 BM454509 AI826749 BG059588 AA487967 BQ722342 
    AA370623 AA487235 BU183731 BQ776312 BU675819 AW262587 AI769225 BQ423322 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCATAACA
    FBXO11 Expression
    About this image


    See FBXO11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO11

    SOURCE GeneReport for Unigene cluster: Hs.352677

    UniProtKB/Swiss-Prot: FBX11_HUMAN, Q86XK2
    Tissue specificity: Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXO11: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO11 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo111 , 5 F-box protein 111, 5 93.45(n)1
    98.92(a)1
      17 (57.87 cM)5
    2250551  NM_001081034.11  NP_001074503.11 
     879908595 
    chicken
    (Gallus gallus)
    Aves FBXO111 F-box protein 11 84.67(n)
    93.71(a)
      421289  XM_419357.3  XP_419357.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO116
    F-box protein 11
    95(a)
    1 ↔ 1
    1(255206463-255298181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.33562 Xenopus laevis transcribed sequence with moderate similarity more 81.64(n)    BU917012.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130732 Transcribed sequence with weak similarity to protein more 78.68(n)    57069785 
    fruit fly
    (Drosophila melanogaster)
    Insecta FBX0111 FBX011 ortholog 64.64(n)
    74.39(a)
      41209  NM_141697.1  NP_649954.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dre-11 Protein DRE-1 57.55(n)
    56.07(a)
      179045  NM_072260.4  NP_504661.1 


    ENSEMBL Gene Tree for FBXO11 (if available)
    TreeFam Gene Tree for FBXO11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO11 gene
    FBXO102  
    3 SIMAP similar genes for FBXO11 using alignment to 8 protein entries:     FBX11_HUMAN (see all proteins):
    FBXO15    FBXO8    UBR5

    FBXO11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2444 SNPs in FBXO11 are shown (see all 2444)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470673671,2
    C--47771247(+) CATGAC/GATTAA 2 -- ut310--------
    rs1996223021,2
    --47771301(+) AAAAA-/TCAAAA 2 -- ut310--------
    rs31363711,2
    C,F,H--47771469(+) GTTGGT/CATCTG 2 -- ut3120Minor allele frequency- C:0.01NS EA NA CSA WA 2066
    rs1891728431,2
    --47771563(+) GAGTCA/GATATA 2 -- ut310--------
    rs37321871,2
    H--47771578(+) CACTTT/CCTTTT 2 -- ut31 trp34Minor allele frequency- C:0.00NS EA 420
    rs1383716331,2
    --47771617(+) GACCTC/TGTGTA 2 -- ut310--------
    rs37321881,2
    C,F,H--47771619(+) CCTTGT/GGTATC 2 -- ut31 ese35Minor allele frequency- G:0.01NS EA 540
    rs2018549811,2
    C--47771699(+) AGTTAC/TGATGT 2 -- ut310--------
    rs2011604611,2
    --47771711(+) ACAATA/GGCAGG 2 -- ut310--------
    rs1818280691,2
    C--47771715(+) TGGCAA/GGACTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXO11 (48016455 - 48132932 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXO11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720032CNV Deletion23290073
    esv2674438CNV Deletion23128226
    esv2720030CNV Deletion23290073
    esv2671167CNV Deletion23128226
    esv2720031CNV Deletion23290073
    nsv523013CNV Loss19592680
    nsv874000CNV Gain21882294
    nsv519831CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607871    OMIM disorders: --

    5 diseases for FBXO11:    About MalaCards
    otitis media    vitiligo    diffuse large b-cell lymphoma    b-cell lymphomas
    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for FBXO11:
    Vitiligo     Otitis media

    FBXO11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO11
    Human Genome Epidemiology (HuGE) Navigator: FBXO11 (4 documents)

    Export disorders for FBXO11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO11 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with FBXO11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. (PubMed id 17098746)1, 2 Abida W.M.... Gu W. (2007)
    4. Association of the FBXO11 gene with chronic otitis media with effusion and recurrent otitis media: the Minnesota COME/ROM Family Study. (PubMed id 16847180)1, 4 Segade F....Bowden D.W. (2006)
    5. FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. (PubMed id 16487488)1, 3 Cook J.R....Pestka S. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. 'VIT1', a novel gene associated with vitiligo. (PubMed id 11775060)1, 2 Le Poole I.C.... Boissy R.E. (2001)
    9. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
    10. The role of VIT1/FBXO11 in the regulation of apoptosi s and tyrosinase export from endoplasmic reticulum in cultured melanocytes. (PubMed id 20514423)1, 9 Guan C....Xu A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80204 HGNC: 13590 AceView: FBXO11 Ensembl:ENSG00000138081 euGenes: HUgn80204
    ECgene: FBXO11 H-InvDB: FBXO11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO11 gene:
    Search GeneIP for patents involving FBXO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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