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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXO10 Gene

protein-coding   GIFtS: 44
GCID: GC09M037510

F-Box Protein 10

(Previous name: F-box only protein 10)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box Protein 101 2
FBX102 3 5
F-Box Only Protein 101 2
PRMT112
F-Box Protein Fbx102

External Ids:    HGNC: 135891   Entrez Gene: 262672   Ensembl: ENSG000001479127   OMIM: 6090925   UniProtKB: Q9UK963   

Export aliases for FBXO10 gene to outside databases

Previous GC identifers: GC09M037844 GC09M037680 GC09M037500 GC09M037502 GC09M037462


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXO10 Gene:
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXO10 Gene: 
FBXO10 (F-box protein 10) is a protein-coding gene. Diseases associated with FBXO10 include breast cancer. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXO11.

UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXO10 gene promoter:
         ISGF-3   Sox5   NRF-2   POU2F1   Bach2   POU2F1a   Sox9   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FBXO10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXO10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.1

FBXO10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M037510:  view genomic region     (about GC identifiers)

Start:
37,510,889 bp from pter      End:
37,588,871 bp from pter
Size:
77,983 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96 (See protein sequence)
Recommended Name: F-box only protein 10  
Size: 956 amino acids; 105195 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Sequence caution: Sequence=AAF03705.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in
the C-terminal part; Sequence=AAF04519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAI16152.1; Type=Erroneous gene model prediction;
Secondary accessions: Q08AL3 Q5JRT8 Q9UKC3

Explore the universe of human proteins at neXtProt for FBXO10: NX_Q9UK96

Explore proteomics data for FBXO10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UK96

  • FBXO10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXO10 Protein Expression
    REFSEQ proteins: NP_036298.2  
    ENSEMBL proteins: 
     ENSP00000403802   ENSP00000276960   ENSP00000440061   ENSP00000441307  

    Human Recombinant Protein Products for FBXO10: 
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    OriGene Protein Over-expression Lysate for FBXO10
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035

    FBXO10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXO: F-boxes / "other"
    PRMT: Protein arginine methyltransferases

    5/7 InterPro protein domains (see all 7):
     IPR012334 Pectin_lyas_fold
     IPR006633 Carb-bd_sugar_hydrolysis-dom
     IPR022441 Para_beta_helix_rpt-2
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q9UK96

    ProtoNet protein and cluster: Q9UK96

    1 Blocks protein domain: IPB006626 Parallel beta-helix repeat

    UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96
    Similarity: Contains 1 F-box domain
    Similarity: Contains 17 PbH1 repeats


    FBXO10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX10_HUMAN, Q9UK96
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding ----
         
    FBXO10 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXO10

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035

    FBXO10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXO10 (FBX10)

    Search CenterWatch for drugs/clinical trials and news about FBXO10 / FBX10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXO10 gene: 
    NM_012166.2  

    Unigene Cluster for FBXO10:

    F-box protein 10
    Hs.709527  [show with all ESTs]
    Unigene Representative Sequence: NM_012166
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432825(uc004aab.3 uc004aac.3 uc004aad.3) ENST00000276960
    ENST00000543968 ENST00000544208 ENST00000541607 ENST00000541829
    miRNA
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    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXO10 (see all 67):
    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-759 hsa-miR-93 hsa-miR-130b hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: FBXO10 (NM_012166)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXO10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXO10

    Additional mRNA sequence: 

    AB209610.1 AF174598.1 AF176705.1 AK123986.1 BC013747.1 BC125124.1 BC125125.1 BC140785.1 
    BC171785.1 

    11 DOTS entries:

    DT.100749872  DT.210877  DT.121192537  DT.121192748  DT.87010394  DT.97784668  DT.113883  DT.101959587 
    DT.65286207  DT.121192561  DT.95161130 

    24/380 AceView cDNA sequences (see all 380):

    AA689455 AA804208 BG163427 BU677935 BQ003913 AI344383 AI720057 AI190955 
    AA904388 BU623815 BM987702 AI935948 BM697723 BQ421660 CB177998 BF515458 
    BM823840 CD676823 AI347672 BF116181 AW027243 AI804567 CA307811 AA384562 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXO10 expression in normal human tissues (normalized intensities)      FBXO10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCTCCC
    FBXO10 Expression
    About this image


    FBXO10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood

    See FBXO10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXO10

    SOURCE GeneReport for Unigene cluster: Hs.709527
        SABiosciences Custom PCR Arrays for FBXO10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO10 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo101 , 5 F-box protein 101, 5 88.35(n)1
    94.32(a)1
      4 (23.68 cM)5
    2695291  NM_001024142.11  NP_001019313.11 
     450342475 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO106
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343201.1(3698354-3741213)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-245p14.21 si:dkey-245p14.2 59.39(n)
    55.27(a)
      563863  NM_001135257.1  NP_001128729.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FBX0116
    FBX011 ortholog
    13(a)
    1 → many
    3R(5630494-5635085)
    worm
    (Caenorhabditis elegans)
    Secernentea dre-16
    BE0003N10.36
    Protein BE0003N10.3
    15(a)
    10(a)
    many ↔ many
    many ↔ many
    V(6533615-6538062)
    III(1046248-1060010)


    ENSEMBL Gene Tree for FBXO10 (if available)
    TreeFam Gene Tree for FBXO10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXO10 gene
    FBXO112  

    FBXO10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1436 SNPs in FBXO10 are shown (see all 1436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508817691,2
    C--37510419(+) ATGTAC/TACTGA 1 -- int10--------
    rs1153513361,2
    F--37510680(+) GGGACG/AGCCTG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs603560871,2
    F--37510730(+) AGCCCG/AATTGA 1 -- int11Minor allele frequency- A:0.10WA 118
    rs413159851,2
    C,F--37510812(+) GTCTCC/TTTCAG 1 -- int15Minor allele frequency- T:0.10NA WA 244
    rs1393347541,2
    --37510886(+) TCCAAA/GAGTGC 1 -- int10--------
    rs11282061,2
    C--37510968(-) ATTTTC/TTAAGA 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs1884005381,2
    --37510998(+) ACAGCA/GACTCA 1 -- ut310--------
    rs1500122911,2
    C--37511073(+) CCCAGC/TGTTCT 1 -- ut310--------
    rs1928573501,2
    --37511114(+) TACCCC/TCTCCC 1 -- ut310--------
    rs1123216661,2
    F--37511250(+) TTGAGC/TTGGCC 1 -- ut311Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for FBXO10 (37510889 - 37588871 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FBXO10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv824923CNV Gain20364138
    nsv893060CNV Gain21882294
    nsv442144CNV CNV18776908
    esv259927OTHER Complex20981092


    Human Gene Mutation Database (HGMD): FBXO10
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO10
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609092    OMIM disorders: --

    2 diseases for FBXO10:    About MalaCards
    breast cancer    


    FBXO10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXO10
    Human Genome Epidemiology (HuGE) Navigator: FBXO10 (3 documents)

    Export disorders for FBXO10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXO10 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with FBXO10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T....Harper J.W. (1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. FGFR2 and other loci identified in genome-wide associ ation studies are associated with breast cancer in African-American and younger women. (PubMed id 20554749)1, 4 Barnholtz-Sloan J.S....Millikan R.C. (2010)
    5. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. (PubMed id 19300908)1, 3 Wolf S.S. (2009)
    6. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    8. Related F-box proteins control cell death in Caenorhab ditis elegans and human lymphoma. (PubMed id 23431138)1 Chiorazzi M....Staudt L.M. (2013)
    9. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26267 HGNC: 13589 AceView: FBXO10 Ensembl:ENSG00000147912 euGenes: HUgn26267
    ECgene: FBXO10 H-InvDB: FBXO10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXO10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXO10 gene:
    Search GeneIP for patents involving FBXO10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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