Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXO10 Gene

protein-coding   GIFtS: 43
GCID: GC09M037510

F-Box Protein 10

(Previous name: F-box only protein 10)
  Search for FBXO10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box Protein 101 2
FBX102 3 5
F-Box Only Protein 101 2
PRMT112
F-Box Protein Fbx102

External Ids:    HGNC: 135891   Entrez Gene: 262672   Ensembl: ENSG000001479127   OMIM: 6090925   UniProtKB: Q9UK963   

Export aliases for FBXO10 gene to outside databases

Previous GC identifers: GC09M037844 GC09M037680 GC09M037500 GC09M037502 GC09M037462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXO10 Gene:
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXO10 Gene:
FBXO10 (F-box protein 10) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXO11.

UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby
playing a role in apoptosis by controlling the stability of BCL2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXO10 gene promoter:
         ISGF-3   Sox5   NRF-2   POU2F1   Bach2   POU2F1a   Sox9   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FBXO10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.1

FBXO10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXO10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M037510:  view genomic region     (about GC identifiers)

Start:
37,510,889 bp from pter      End:
37,588,871 bp from pter
Size:
77,983 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96 (See protein sequence)
Recommended Name: F-box only protein 10  
Size: 956 amino acids; 105195 Da
Subunit: Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10. Interacts with BCL2
Sequence caution: Sequence=AAF03705.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAF03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in
the C-terminal part; Sequence=AAF04519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAI16152.1; Type=Erroneous gene model prediction;
Secondary accessions: Q08AL3 Q5JRT8 Q9UKC3

Explore the universe of human proteins at neXtProt for FBXO10: NX_Q9UK96

Explore proteomics data for FBXO10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXO10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036298.2  
    ENSEMBL proteins: 
     ENSP00000403802   ENSP00000276960   ENSP00000440061   ENSP00000441307  

    FBXO10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBXO10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FBXO10
    GenScript Custom Purified and Recombinant Proteins Services for FBXO10
    Novus Biologicals FBXO10 Protein
    Novus Biologicals FBXO10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXO10

     
    Search eBioscience for Proteins for FBXO10 

    FBXO10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXO10
    Novus Biologicals FBXO10 Antibodies
    Abcam antibodies for FBXO10
    Cloud-Clone Corp. Antibodies for FBXO10
    Search ThermoFisher Antibodies for FBXO10
    LSBio Antibodies in human, mouse, rat for FBXO10

    FBXO10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXO10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXO10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXO10
    Cloud-Clone Corp. CLIAs for FBXO10
    Search eBioscience for ELISAs for FBXO10 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FBXO: F-boxes / "other"

    Selected InterPro protein domains (see all 7):
     IPR012334 Pectin_lyas_fold
     IPR006633 Carb-bd_sugar_hydrolysis-dom
     IPR022441 Para_beta_helix_rpt-2
     IPR011050 Pectin_lyase_fold/virulence
     IPR006626 PbH1

    Graphical View of Domain Structure for InterPro Entry Q9UK96

    ProtoNet protein and cluster: Q9UK96

    1 Blocks protein domain: IPB006626 Parallel beta-helix repeat

    UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96
    Similarity: Contains 1 F-box domain
    Similarity: Contains 17 PbH1 repeats


    Find genes that share domains with FBXO10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBX10_HUMAN, Q9UK96
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
    The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby
    playing a role in apoptosis by controlling the stability of BCL2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with FBXO10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXO10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXO10

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXO10:
    hsa-mir-125a-5p (MIRT045730)

    Block miRNA regulation of human, mouse, rat FBXO10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO10 (see all 67):
    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-759 hsa-miR-93 hsa-miR-130b hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXO10
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXO10

    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO10 (see all 8)
    OriGene ORF clones in mouse, rat for FBXO10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO10 (NM_012166)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXO10
    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FBX10_HUMAN, Q9UK96: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with FBXO10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXO10
    Interactions:

        Search GeneGlobe Interaction Network for FBXO10

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IMP--
    GO:0016567protein ubiquitination NAS10531035
    GO:0042981regulation of apoptotic process IMP--

    Find genes that share ontologies with FBXO10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXO10 (FBX10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FBXO10 gene: 
    NM_012166.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432825(uc004aab.3 uc004aac.3 uc004aad.3) ENST00000276960
    ENST00000543968 ENST00000544208 ENST00000541607 ENST00000541829
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXO10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXO10 (see all 67):
    hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-759 hsa-miR-93 hsa-miR-130b hsa-miR-30b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXO10
    Predesigned siRNA for gene silencing in human, mouse, rat FBXO10
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXO10 (see all 8)
    OriGene ORF clones in mouse, rat for FBXO10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXO10 (NM_012166)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXO10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXO10
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO10
      QuantiTect SYBR Green Assays in human, mouse, rat FBXO10
      QuantiFast Probe-based Assays in human, mouse, rat FBXO10

    Selected AceView cDNA sequences (see all 380):

    AA372685 BQ023927 AI720057 Z42863 BQ711329 AA904388 AI566148 AI028029 
    BQ003913 BE018481 BM142571 BM987702 AA131520 BQ882238 BC013747 AW273911 
    AA778041 BU173963 BU623815 BG654365 CB177998 AI097361 AA384562 AI935948 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FBXO10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTCTCCC
    FBXO10 Expression
    About this image


    FBXO10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    FBXO10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXO10 Protein Expression
        Custom PCR Arrays for FBXO10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXO10
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXO10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO10
    QuantiTect SYBR Green Assays in human, mouse, rat FBXO10
    QuantiFast Probe-based Assays in human, mouse, rat FBXO10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FBXO10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxo101 , 5 F-box protein 101, 5 88.21(n)1
    94.11(a)1
      4 (23.68 cM)5
    2695291  NM_001024142.11  NP_001019313.11 
     450342475 
    lizard
    (Anolis carolinensis)
    Reptilia FBXO106
    F-box protein 10
    59(a)
    1 ↔ 1
    GL343201.1(3698354-3741213)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fbxo101 F-box protein 10 66.04(n)
    64.29(a)
      100493653  XM_002935876.2  XP_002935922.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-245p14.21 si:dkey-245p14.2 58.96(n)
    53.99(a)
      563863  NM_001135257.1  NP_001128729.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FBX0116
    FBX011 ortholog
    13(a)
    1 → many
    3R(5630494-5635085)
    worm
    (Caenorhabditis elegans)
    Secernentea dre-16
    BE0003N10.36
    Protein DRE-1 (dre-1) mRNA, complete cds
    Protein BE0003N10.3 (BE0003N10.3) mRNA, complete c...
    16(a)
    11(a)
    many ↔ many
    many ↔ many
    V(6533615-6538062) WBGene00001089
    III(1046248-1060010) WBGene00015268


    ENSEMBL Gene Tree for FBXO10 (if available)
    TreeFam Gene Tree for FBXO10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FBXO10 gene
    FBXO112  

    Find genes that share paralogs with FBXO10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FBXO10 (see all 1439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508817691,2
    C--37510419(+) ATGTAC/TACTGA 1 -- int10--------
    rs1153513361,2
    F--37510680(+) GGGACG/AGCCTG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs603560871,2
    F--37510730(+) AGCCCG/AATTGA 1 -- int11Minor allele frequency- A:0.10WA 118
    rs413159851,2
    C,F--37510812(+) GTCTCC/TTTCAG 1 -- int15Minor allele frequency- T:0.10NA WA 244
    rs1393347541,2
    --37510886(+) TCCAAA/GAGTGC 1 -- int10--------
    rs11282061,2
    C--37510968(-) ATTTTC/TTAAGA 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs1884005381,2
    --37510998(+) ACAGCA/GACTCA 1 -- ut310--------
    rs1500122911,2
    C--37511073(+) CCCAGC/TGTTCT 1 -- ut310--------
    rs1928573501,2
    --37511114(+) TACCCC/TCTCCC 1 -- ut310--------
    rs1123216661,2
    F--37511250(+) TTGAGC/TTGGCC 1 -- ut311Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for FBXO10 (37510889 - 37588871 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FBXO10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv824923CNV Gain20364138
    nsv893060CNV Gain21882294
    nsv442144CNV CNV18776908
    esv259927OTHER Complex20981092

    Human Gene Mutation Database (HGMD): FBXO10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXO10
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXO10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609092    OMIM disorders: --

    UniProtKB/Swiss-Prot: FBX10_HUMAN, Q9UK96
  • Note=Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of
    BCL2, an oncoprotein that has a critical role in lymphomas (PubMed:23431138)


  • Find genes that share disorders with FBXO10           About GenesLikeMe

    Genetic Association Database (GAD): FBXO10
    Human Genome Epidemiology (HuGE) Navigator: FBXO10 (3 documents)

    Export disorders for FBXO10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FBXO10 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with FBXO10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    2. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    3. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. (PubMed id 23431138)1, 2 Chiorazzi M....Staudt L.M. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. (PubMed id 20554749)1, 4 Barnholtz-Sloan J.S....Millikan R.C. (Carcinogenesis 2010)
    6. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. (PubMed id 19300908)1, 3 Wolf S.S. (Cell. Mol. Life Sci. 2009)
    7. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26267 HGNC: 13589 AceView: FBXO10 Ensembl:ENSG00000147912 euGenes: HUgn26267
    ECgene: FBXO10 H-InvDB: FBXO10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FBXO10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FBXO10 gene:
    Search GeneIP for patents involving FBXO10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXO10  
     OriGene qPCR primer pairs and template standards for FBXO10   OriGene Protein Over-expression Lysate for FBXO10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXO10  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXO10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXO10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXO10   OriGene Custom Protein Services for FBXO10  

     
     
     Block miRNA regulation of human, mouse, rat FBXO10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXO10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXO10 Predesigned siRNA for gene silencing in human, mouse, rat FBXO10
     QuantiFast Probe-based Assays in human, mouse, rat FBXO10 QuantiTect SYBR Green Assays in human, mouse, rat FBXO10
     Custom PCR Arrays for FBXO10 Search Chromatin IP Primers for FBXO10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXO10  Search GeneGlobe Interaction Network for FBXO10
     Regulatory tfbs in FBXO10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FBXO10 GenScript cDNA clones with any tag delivered in your preferred vector for FBXO10
     GenScript Custom Assay Services for FBXO10 GenScript Custom overexpressing Cell Line Services for FBXO10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FBXO10 (FBX10)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FBXO10 antibodies
     FBXO10 proteins
     FBXO10 lysates
     Antibodies for FBXO10
     See all of Abcam's Antibodies, Kits and Proteins for FBXO10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FBXO10
     Antibodies for FBXO10
     ELISAs for FBXO10
     CLIAs for FBXO10



     Browse ESI BIO Cell Lines and PureStem Progenitors for FBXO10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXO10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FBXO10
     Browse SwitchGear Promoter luciferase reporter plasmids for FBXO10
     Search ThermoFisher Antibodies for FBXO10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXO10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXO10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXO10
     LSBio Antibodies in human, mouse, rat for FBXO10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FBXO10
      Search eBioscience for proteins for FBXO10
      Search eBioscience for elisas for FBXO10
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXO10 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4