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FBXO10 Gene(Protein Coding)

F-Box Protein 10

GCID:
GC09M037510
GIFtS:
49
Genes Participants
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Aliases for FBXO10 Gene

Aliases for FBXO10 Gene

  • F-Box Protein 10 2 3 5
  • F-Box Only Protein 10 2 3
  • PRMT11 3 4
  • FBX10 3 4
  • F-Box Protein Fbx10 3

External Ids for FBXO10 Gene

Previous GeneCards Identifiers for FBXO10 Gene

  • GC09M037844
  • GC09M037680
  • GC09M037500
  • GC09M037502
  • GC09M037462

Summaries for FBXO10 Gene

Entrez Gene Summary for FBXO10 Gene

  • Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO10 Gene

FBXO10 (F-Box Protein 10) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXO11.

UniProtKB/Swiss-Prot for FBXO10 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO10 Gene

Genomics for FBXO10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBXO10 Gene

Enhancers for FBXO10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G037485 1.3 ENCODE dbSUPER 16.3 +89.5 89549 3.5 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 RPL21P83 POLR1E ZBTB5 EXOSC3 FBXO10 ENSG00000234160 TOMM5 ENSG00000256966 FRMPD1 GRHPR
GH09G037573 1 ENCODE 15.2 +0.6 605 3.6 FOXA2 ARNT ARID4B SIN3A GLIS2 ZNF143 ZNF207 KAT8 SMARCA4 MXD3 FBXO10 POLR1E ZBTB5 GC09M037564
GH09G037550 0.4 ENCODE 20.1 +25.3 25278 1.3 SCRT1 SCRT2 FBXO10 ENSG00000234160 TOMM5 ENSG00000256966 POLR1E FRMPD1 PIR31436 GC09M037564
GH09G037667 0.7 Ensembl ENCODE 10.7 -91.9 -91872 1.0 CTCF TEAD4 ENSG00000256966 TOMM5 FBXO10 FRMPD1 GC09M037661 RN7SKP171 TRMT10B
GH09G037621 0.5 ENCODE 12.6 -45.1 -45110 0.2 ZNF316 NFE2 MAFK TOMM5 ENSG00000256966 FBXO10 FRMPD1 GC09M037636
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXO10 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234877 149 1201 FOXA2 ARNT ARID4B SIN3A GLIS2 ZNF143 ZNF207 KAT8 SMARCA4 MXD3

Transcription factor binding sites by QIAGEN in the FBXO10 gene promoter:

Genomic Location for FBXO10 Gene

Chromosome:
9
Start:
37,510,892 bp from pter
End:
37,576,349 bp from pter
Size:
65,458 bases
Orientation:
Minus strand

Genomic View for FBXO10 Gene

Genes around FBXO10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBXO10 Gene

Proteins for FBXO10 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for FBXO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK96-FBX10_HUMAN
    Recommended name:
    F-box only protein 10
    Protein Accession:
    Q9UK96
    Secondary Accessions:
    • Q08AL3
    • Q08AL4
    • Q5JRT8
    • Q9UKC3

    Protein attributes for FBXO10 Gene

    Size:
    956 amino acids
    Molecular mass:
    105195 Da
    Quaternary structure:
    • Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10 (PubMed:23431138). Interacts with BCL2 (PubMed:23431138). Interacts with PRDM1 (PubMed:24613396).
    SequenceCaution:
    • Sequence=AAF03705.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAF04519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI16152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO10 Gene

Protein Expression for FBXO10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FBXO10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO10 Gene

Domains & Families for FBXO10 Gene

Gene Families for FBXO10 Gene

HGNC:

Protein Domains for FBXO10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXO10: view

No data available for UniProtKB/Swiss-Prot for FBXO10 Gene

Function for FBXO10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBXO10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.

Gene Ontology (GO) - Molecular Function for FBXO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 23431138
genes like me logo Genes that share ontologies with FBXO10: view

Phenotypes for FBXO10 Gene

GenomeRNAi human phenotypes for FBXO10:
genes like me logo Genes that share phenotypes with FBXO10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO10 Gene

Localization for FBXO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXO10 gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBXO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005737 cytoplasm IEA,IDA 23431138
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXO10: view

Pathways & Interactions for FBXO10 Gene

genes like me logo Genes that share pathways with FBXO10: view

UniProtKB/Swiss-Prot Q9UK96-FBX10_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination NAS 10531035
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP 23431138
GO:0042981 regulation of apoptotic process IMP 23431138
genes like me logo Genes that share ontologies with FBXO10: view

No data available for SIGNOR curated interactions for FBXO10 Gene

Drugs & Compounds for FBXO10 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FBXO10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBXO10 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(380) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXO10 Gene

F-box protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO10 Gene

No ASD Table

Relevant External Links for FBXO10 Gene

GeneLoc Exon Structure for
FBXO10
ECgene alternative splicing isoforms for
FBXO10

Expression for FBXO10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXO10 Gene

mRNA expression in normal human tissues for FBXO10 Gene
mRNA expression by BioGPS for FBXO10 GenemRNA expression by GTEx for FBXO10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO10 Gene

This gene is overexpressed in Muscle - Skeletal (x6.9).

Protein differential expression in normal tissues from HIPED for FBXO10 Gene

This gene is overexpressed in Fetal gut (32.2) and Heart (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO10 Gene



Protein tissue co-expression partners for FBXO10 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXO10 Gene:

FBXO10

SOURCE GeneReport for Unigene cluster for FBXO10 Gene:

Hs.709527
genes like me logo Genes that share expression patterns with FBXO10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXO10 Gene

Orthologs for FBXO10 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBXO10 34 35
  • 99.72 (n)
dog
(Canis familiaris)
 Mammalia FBXO10 34 35
  • 90.41 (n)
cow
(Bos Taurus)
 Mammalia FBXO10 34 35
  • 88.82 (n)
mouse
(Mus musculus)
 Mammalia Fbxo10 34 16 35
  • 88.21 (n)
rat
(Rattus norvegicus)
 Mammalia Fbxo10 34
  • 87.68 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 79 (a)
 OneToMany
-- 35
  • 35 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia FBXO10 35
  • 61 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FBXO10 35
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbxo10 34
  • 66.04 (n)
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-245p14.2 34
  • 58.96 (n)
FBXO10 (1 of 2) 35
  • 45 (a)
 OneToMany
FBXO10 (2 of 2) 35
  • 30 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta FBX011 35
  • 13 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea dre-1 35
  • 16 (a)
 ManyToMany
BE0003N10.3 35
  • 11 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 17 (a)
 OneToMany
Species where no ortholog for FBXO10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO10 Gene

ENSEMBL:
Gene Tree for FBXO10 (if available)
TreeFam:
Gene Tree for FBXO10 (if available)

Paralogs for FBXO10 Gene

Paralogs for FBXO10 Gene

genes like me logo Genes that share paralogs with FBXO10: view

Variants for FBXO10 Gene

Sequence variations from dbSNP and Humsavar for FBXO10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000013762 -- 37,570,212(+) AGGCT(A/G)AGGAG intron-variant
rs1000135741 -- 37,571,526(+) TGTCC(C/T)TTTCT intron-variant
rs1000169165 -- 37,533,118(+) ATAAA(G/T)GGATA intron-variant, upstream-variant-2KB
rs1000175726 -- 37,521,310(+) GCTGT(A/C)TGGGA intron-variant
rs1000222462 -- 37,532,730(+) GATGA(C/T)GGGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXO10 Gene

Variant ID Type Subtype PubMed ID
dgv274n111 CNV duplication 26073780
esv3302953 CNV tandem duplication 20981092
esv3620409 CNV gain 21293372
nsv1115175 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv442144 CNV gain 18776908
nsv824923 CNV gain 20364138

Variation tolerance for FBXO10 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO10 Gene

Human Gene Mutation Database (HGMD)
FBXO10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXO10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO10 Gene

Disorders for FBXO10 Gene

UniProtKB/Swiss-Prot

FBX10_HUMAN
  • Note=Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas. {ECO:0000269 PubMed:23431138}.

Relevant External Links for FBXO10

Genetic Association Database (GAD)
FBXO10
Human Genome Epidemiology (HuGE) Navigator
FBXO10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO10

No disorders were found for FBXO10 Gene.

No data available for MalaCards and Genatlas for FBXO10 Gene

Publications for FBXO10 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 64
  3. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. (PMID: 23431138) Chiorazzi M. … Staudt L.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. (PMID: 20554749) Barnholtz-Sloan J.S. … Millikan R.C. (Carcinogenesis 2010) 3 46 64

Products for FBXO10 Gene

Sources for FBXO10 Gene

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