Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXO10 Gene

Aliases for FBXO10 Gene

  • F-Box Protein 10 2 3 5
  • PRMT11 3 4
  • FBX10 3 4
  • F-Box Only Protein 10 2
  • F-Box Protein Fbx10 3

External Ids for FBXO10 Gene

Previous GeneCards Identifiers for FBXO10 Gene

  • GC09M037844
  • GC09M037680
  • GC09M037500
  • GC09M037502
  • GC09M037462

Summaries for FBXO10 Gene

Entrez Gene Summary for FBXO10 Gene

  • Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXO10 Gene

FBXO10 (F-Box Protein 10) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXO11.

UniProtKB/Swiss-Prot for FBXO10 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXO10 Gene

Genomics for FBXO10 Gene

Regulatory Elements for FBXO10 Gene

Enhancers for FBXO10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXO10 on UCSC Golden Path with GeneCards custom track

Promoters for FBXO10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXO10 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXO10 Gene

Chromosome:
9
Start:
37,510,892 bp from pter
End:
37,576,349 bp from pter
Size:
65,458 bases
Orientation:
Minus strand

Genomic View for FBXO10 Gene

Genes around FBXO10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXO10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXO10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXO10 Gene

Proteins for FBXO10 Gene

  • Protein details for FBXO10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK96-FBX10_HUMAN
    Recommended name:
    F-box only protein 10
    Protein Accession:
    Q9UK96
    Secondary Accessions:
    • Q08AL3
    • Q08AL4
    • Q5JRT8
    • Q9UKC3

    Protein attributes for FBXO10 Gene

    Size:
    956 amino acids
    Molecular mass:
    105195 Da
    Quaternary structure:
    • Component of the SCF(FBXO10) complex consisting of CUL1, SKP1 and FBXO10 (PubMed:23431138). Interacts with BCL2 (PubMed:23431138). Interacts with PRDM1 (PubMed:24613396).
    SequenceCaution:
    • Sequence=AAF03705.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF03705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAF04519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI16152.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXO10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXO10 Gene

Proteomics data for FBXO10 Gene at MOPED

Post-translational modifications for FBXO10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXO10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXO10 Gene

Domains & Families for FBXO10 Gene

Gene Families for FBXO10 Gene

Suggested Antigen Peptide Sequences for FBXO10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK96

UniProtKB/Swiss-Prot:

FBX10_HUMAN :
  • Contains 1 F-box domain.
  • Contains 17 PbH1 repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 17 PbH1 repeats.
genes like me logo Genes that share domains with FBXO10: view

Function for FBXO10 Gene

Molecular function for FBXO10 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.

Gene Ontology (GO) - Molecular Function for FBXO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXO10: view

Phenotypes for FBXO10 Gene

genes like me logo Genes that share phenotypes with FBXO10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXO10 Gene

Localization for FBXO10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXO10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXO10 Gene COMPARTMENTS Subcellular localization image for FBXO10 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for FBXO10 Gene

Pathways & Interactions for FBXO10 Gene

SuperPathways for FBXO10 Gene

No Data Available

UniProtKB/Swiss-Prot Q9UK96-FBX10_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for FBXO10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000403802%0d%0a9606.ENSP00000326804%0d%0a9606.ENSP00000335153%0d%0a9606.ENSP00000325875%0d%0a
Selected Interacting proteins: ENSP00000403802 for FBXO10 Gene via STRING

Gene Ontology (GO) - Biological Process for FBXO10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP 23431138
genes like me logo Genes that share ontologies with FBXO10: view

No data available for Pathways by source and SIGNOR curated interactions for FBXO10 Gene

Drugs & Compounds for FBXO10 Gene

No Compound Related Data Available

Transcripts for FBXO10 Gene

Unigene Clusters for FBXO10 Gene

F-box protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXO10 Gene

No ASD Table

Relevant External Links for FBXO10 Gene

GeneLoc Exon Structure for
FBXO10
ECgene alternative splicing isoforms for
FBXO10

Expression for FBXO10 Gene

mRNA expression in normal human tissues for FBXO10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXO10 Gene

This gene is overexpressed in Muscle - Skeletal (x6.9).

Protein differential expression in normal tissues from HIPED for FBXO10 Gene

This gene is overexpressed in Fetal gut (32.2) and Heart (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXO10 Gene



SOURCE GeneReport for Unigene cluster for FBXO10 Gene Hs.709527

genes like me logo Genes that share expression patterns with FBXO10: view

Protein tissue co-expression partners for FBXO10 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXO10 Gene

Orthologs for FBXO10 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXO10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXO10 35
  • 88.82 (n)
  • 90.64 (a)
FBXO10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXO10 35
  • 90.41 (n)
  • 94.87 (a)
FBXO10 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxo10 35
  • 88.21 (n)
  • 94.11 (a)
Fbxo10 16
Fbxo10 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXO10 35
  • 99.72 (n)
  • 99.9 (a)
FBXO10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxo10 35
  • 87.68 (n)
  • 93.26 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXO10 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia FBXO10 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxo10 35
  • 66.04 (n)
  • 64.29 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-245p14.2 35
  • 58.96 (n)
  • 53.99 (a)
FBXO10 (1 of 2) 36
  • 45 (a)
OneToMany
FBXO10 (2 of 2) 36
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FBX011 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea BE0003N10.3 36
  • 11 (a)
ManyToMany
dre-1 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for FBXO10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXO10 Gene

ENSEMBL:
Gene Tree for FBXO10 (if available)
TreeFam:
Gene Tree for FBXO10 (if available)

Paralogs for FBXO10 Gene

Paralogs for FBXO10 Gene

genes like me logo Genes that share paralogs with FBXO10: view

Variants for FBXO10 Gene

Sequence variations from dbSNP and Humsavar for FBXO10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7044561 - 37,537,895(+) GATGT(G/T)CCCGT nc-transcript-variant, reference, missense
VAR_070692 -
VAR_070693 -
VAR_070694 -
rs717739 -- 37,543,793(+) ACCTA(G/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXO10 Gene

Variant ID Type Subtype PubMed ID
esv259927 OTHER Complex 20981092
nsv824923 CNV Gain 20364138
nsv442144 CNV CNV 18776908
nsv893060 CNV Gain 21882294

Variation tolerance for FBXO10 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXO10 Gene

Human Gene Mutation Database (HGMD)
FBXO10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXO10 Gene

Disorders for FBXO10 Gene

UniProtKB/Swiss-Prot

FBX10_HUMAN
  • Note=Defects in FBXO10 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL2, an oncoprotein that has a critical role in lymphomas. {ECO:0000269 PubMed:23431138}.

Relevant External Links for FBXO10

Genetic Association Database (GAD)
FBXO10
Human Genome Epidemiology (HuGE) Navigator
FBXO10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXO10

No disorders were found for FBXO10 Gene.

No data available for MalaCards and Genatlas for FBXO10 Gene

Publications for FBXO10 Gene

  1. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 4 67
  2. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. (PMID: 19300908) Wolf S.S. (Cell. Mol. Life Sci. 2009) 2 3
  3. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1I+ mRNA. (PMID: 26187670) Ju U.I. … Chun Y.S. (Biochem. Biophys. Res. Commun. 2015) 3

Products for FBXO10 Gene

Sources for FBXO10 Gene

Content