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Aliases for FBXL8 Gene

Aliases for FBXL8 Gene

  • F-Box And Leucine-Rich Repeat Protein 8 2 3 4
  • FBL8 3 4 6
  • F-Box Protein FBL8 3 4
  • F-Box/LRR-Repeat Protein 8 3

External Ids for FBXL8 Gene

Summaries for FBXL8 Gene

Entrez Gene Summary for FBXL8 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXL8 Gene

FBXL8 (F-Box And Leucine-Rich Repeat Protein 8) is a Protein Coding gene. An important paralog of this gene is ENSG00000265690.

UniProtKB/Swiss-Prot for FBXL8 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL8 Gene

Genomics for FBXL8 Gene

Genomic Location for FBXL8 Gene

Start:
67,159,931 bp from pter
End:
67,164,570 bp from pter
Size:
4,640 bases
Orientation:
Plus strand

Genomic View for FBXL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL8 Gene

Regulatory Elements for FBXL8 Gene

Proteins for FBXL8 Gene

  • Protein details for FBXL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CD0-FBXL8_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 8
    Protein Accession:
    Q96CD0
    Secondary Accessions:
    • Q9NUM0

    Protein attributes for FBXL8 Gene

    Size:
    374 amino acids
    Molecular mass:
    40516 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXL8 Gene

Proteomics data for FBXL8 Gene at MOPED

Post-translational modifications for FBXL8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FBXL8 Gene

Domains for FBXL8 Gene

Gene Families for FBXL8 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL8 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

FBXL8_HUMAN
Domain:
  • Contains 1 F-box domain.:
    • Q96CD0
genes like me logo Genes that share domains with FBXL8: view

Function for FBXL8 Gene

Molecular function for FBXL8 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19159283
genes like me logo Genes that share ontologies with FBXL8: view

Phenotypes for FBXL8 Gene

GenomeRNAi human phenotypes for FBXL8:
genes like me logo Genes that share phenotypes with FBXL8: view

miRNA for FBXL8 Gene

miRTarBase miRNAs that target FBXL8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXL8 Gene

Localization for FBXL8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL8 Gene COMPARTMENTS Subcellular localization image for FBXL8 gene
Compartment Confidence
extracellular 3
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FBXL8 Gene

Pathways for FBXL8 Gene

SuperPathways for FBXL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL8 Gene

None

No data available for Pathways by source for FBXL8 Gene

Transcripts for FBXL8 Gene

mRNA/cDNA for FBXL8 Gene

Unigene Clusters for FBXL8 Gene

F-box and leucine-rich repeat protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8: - -
SP9: - -

Relevant External Links for FBXL8 Gene

GeneLoc Exon Structure for
FBXL8
ECgene alternative splicing isoforms for
FBXL8

Expression for FBXL8 Gene

mRNA expression in normal human tissues for FBXL8 Gene

mRNA differential expression in normal tissues according to GTEx for FBXL8 Gene

This gene is overexpressed in Pituitary (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL8 Gene

SOURCE GeneReport for Unigene cluster for FBXL8 Gene Hs.710714

genes like me logo Genes that share expressions with FBXL8: view

Orthologs for FBXL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL8 36
  • 99.55 (n)
  • 99.2 (a)
FBXL8 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FBXL8 36
  • 85.65 (n)
  • 86.36 (a)
FBXL8 37
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 84 (a)
OneToMany
FBXL8 36
  • 84.49 (n)
  • 84.49 (a)
mouse
(Mus musculus)
Mammalia Fbxl8 36
  • 79.71 (n)
  • 78.82 (a)
Fbxl8 16
Fbxl8 37
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxl8 36
  • 77.48 (n)
  • 78.55 (a)
chicken
(Gallus gallus)
Aves FBXL8 36
  • 52.33 (n)
  • 41.64 (a)
FBXL8 37
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 32 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl8 36
  • 45.86 (n)
  • 36.67 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxl8 36
  • 47.84 (n)
  • 40.22 (a)
fbxl8 37
  • 39 (a)
OneToMany
Species with no ortholog for FBXL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL8 Gene

ENSEMBL:
Gene Tree for FBXL8 (if available)
TreeFam:
Gene Tree for FBXL8 (if available)

Paralogs for FBXL8 Gene

Paralogs for FBXL8 Gene

genes like me logo Genes that share paralogs with FBXL8: view

Variants for FBXL8 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXL8 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680

Relevant External Links for FBXL8 Gene

HapMap Linkage Disequilibrium report
FBXL8

No data available for Sequence variations from dbSNP and Humsavar for FBXL8 Gene

Disorders for FBXL8 Gene

Relevant External Links for FBXL8

Genetic Association Database (GAD)
FBXL8
Human Genome Epidemiology (HuGE) Navigator
FBXL8
genes like me logo Genes that share disorders with FBXL8: view

No data available for UniProtKB/Swiss-Prot for FBXL8 Gene

Publications for FBXL8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for FBXL8 Gene

Sources for FBXL8 Gene

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