Aliases for FBXL8 Gene
Aliases for FBXL8 Gene
External Ids for FBXL8 Gene
- HGNC: 17875
- Entrez Gene: 55336
- Ensembl: ENSG00000135722
- OMIM: 609077
- UniProtKB: Q96CD0
Previous GeneCards Identifiers for FBXL8 Gene
- GC16U990141
- GC16P067571
- GC16P066929
- GC16P066970
- GC16P065751
- GC16P053067
Summaries for FBXL8 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXL8 Gene
FBXL8 (F-Box And Leucine Rich Repeat Protein 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ENSG00000265690.
UniProtKB/Swiss-Prot for FBXL8 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL8 Gene
Genomics for FBXL8 Gene
Regulatory Elements for FBXL8 Gene
Enhancers for FBXL8 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXL8 gene promoter:
Regulatory Element Products
Genomic Location for FBXL8 Gene
- Chromosome:
- 16
- Start:
- 67,159,931 bp from pter
- End:
- 67,164,570 bp from pter
- Size:
- 4,640 bases
- Orientation:
- Plus strand
Genomic View for FBXL8 Gene
Genes around FBXL8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
FBXL8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL8 Gene
Proteins for FBXL8 Gene
-
Protein details for FBXL8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96CD0-FBXL8_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 8
- Protein Accession:
- Q96CD0
- Q9NUM0
Protein attributes for FBXL8 Gene
- Size:
- 374 amino acids
- Molecular mass:
- 40516 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
Protein Expression for FBXL8 Gene
Post-translational modifications for FBXL8 Gene
No Post-translational modifications
Other Protein References for FBXL8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL8
-
Abcam antibodies for FBXL8
- Invitrogen Antibodies for FBXL8
- antibodies-online Antibodies for FBXL8: See all 39
- GeneTex FBXL8 antibody for FBXL8
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXL8
Protein Products
-
OriGene Purified Proteins for FBXL8
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL8
- Origene Custom Protein Services for FBXL8
- antibodies-online Proteins for FBXL8: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL8
-
Abcam proteins for FBXL8
Assay Products
- antibodies-online Kits for FBXL8: See all 21
No data available for DME Specific Peptides for FBXL8 Gene
Domains & Families for FBXL8 Gene
Gene Families for FBXL8 Gene
Protein Domains for FBXL8 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL8 Gene
Function for FBXL8 Gene
Molecular function for FBXL8 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 19159283 |
Phenotypes for FBXL8 Gene
- GenomeRNAi human phenotypes for FBXL8:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL8 gene
-
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- Search ViGene Biosciences for FBXL8
CRISPR Products
-
OriGene CRISPR knockouts for FBXL8
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL8
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miRNA for FBXL8 Gene
- miRTarBase miRNAs that target FBXL8
miRNA Products
- Search ViGene Biosciences for FBXL8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL8
- Browse OriGene Inhibitory RNA Products For FBXL8
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL8 gene
Clone Products
-
OriGene ORF clones in human for FBXL8
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Cell Line Products
-
Horizon Cell Lines for FBXL8
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL8 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL8 Gene
Localization for FBXL8 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 3 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL8 Gene
Pathways & Interactions for FBXL8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL8 Gene
4 Reactome pathways for FBXL8 Gene
Interacting Proteins for FBXL8 Gene
Selected Interacting proteins:
Q96CD0-FBXL8_HUMAN
ENSP00000258200
for FBXL8 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL8 Gene
Transcripts for FBXL8 Gene
mRNA/cDNA for FBXL8 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL8
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL8
- GenScript: Design CRISPR guide RNA sequences for FBXL8
miRNA Products
- Search ViGene Biosciences for FBXL8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL8
- Browse OriGene Inhibitory RNA Products For FBXL8
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL8 gene
Clone Products
-
OriGene ORF clones in human for FBXL8
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for FBXL8 Gene
mRNA differential expression in normal tissues according to GTEx for FBXL8 Gene
This gene is overexpressed in Pituitary (x5.4).
This gene is overexpressed in Salivary gland (8.5), Stomach (7.1), Peripheral blood mononuclear cells (6.7), Islet of Langerhans (6.6), and Uterus (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL8 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL8 Gene:
FBXL8SOURCE GeneReport for Unigene cluster for FBXL8 Gene:
Hs.710714Evidence on tissue expression from TISSUES for FBXL8 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXL8
-
OriGene qPCR primer pairs for FBXL8
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL8 Gene
Orthologs for FBXL8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL8 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL8 34 |
|
||
| -- 35 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Fbxl8 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl8 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | FBXL8 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl8 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxl8 34 35 |
|
- Species where no ortholog for FBXL8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL8 Gene
Paralogs for FBXL8 Gene
Variants for FBXL8 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs140579779 | Likely benign | 67,164,562(+) | CACCC(C/T)ACCCC | downstream-variant-500B, utr-variant-5-prime | |
| rs192479571 | Likely benign | 67,164,589(+) | CCCCT(C/T)CACTC | downstream-variant-500B, utr-variant-5-prime | |
| rs200404151 | Likely benign | 67,163,728(+) | TGCTG(C/G)ACGCC | reference, missense, utr-variant-5-prime | |
| rs201429195 | Likely benign | 67,163,470(+) | AGCTG(C/G)AGCCC | reference, missense, utr-variant-5-prime | |
| rs201963745 | Likely benign | 67,163,518(+) | CAGCC(A/G)TCCCC | reference, missense, utr-variant-5-prime |
Gene Damage Index Score:
3.27;
52.93% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXL8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL8 Gene
Disorders for FBXL8 Gene
Relevant External Links for FBXL8
No disorders were found for FBXL8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL8 Gene
Publications for FBXL8 Gene
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for FBXL8 Gene
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- Abcam antibodies for FBXL8
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- antibodies-online Antibodies for FBXL8: See all 39
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer