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Aliases for FBXL8 Gene

Aliases for FBXL8 Gene

  • F-Box And Leucine-Rich Repeat Protein 8 2 3 4
  • F-Box Protein FBL8 3 4
  • FBL8 3 4

External Ids for FBXL8 Gene

Previous GeneCards Identifiers for FBXL8 Gene

  • GC16U990141
  • GC16P067571
  • GC16P066929
  • GC16P066970
  • GC16P065751
  • GC16P053067

Summaries for FBXL8 Gene

Entrez Gene Summary for FBXL8 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXL8 Gene

FBXL8 (F-Box And Leucine-Rich Repeat Protein 8) is a Protein Coding gene. An important paralog of this gene is ENSG00000265690.

UniProtKB/Swiss-Prot for FBXL8 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL8 Gene

Genomics for FBXL8 Gene

Regulatory Elements for FBXL8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL8 Gene

67,159,931 bp from pter
67,164,570 bp from pter
4,640 bases
Plus strand

Genomic View for FBXL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL8 Gene

Proteins for FBXL8 Gene

  • Protein details for FBXL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 8
    Protein Accession:
    Secondary Accessions:
    • Q9NUM0

    Protein attributes for FBXL8 Gene

    374 amino acids
    Molecular mass:
    40516 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

neXtProt entry for FBXL8 Gene

Proteomics data for FBXL8 Gene at MOPED

Post-translational modifications for FBXL8 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for FBXL8 Gene

Domains & Families for FBXL8 Gene

Gene Families for FBXL8 Gene

Protein Domains for FBXL8 Gene


Suggested Antigen Peptide Sequences for FBXL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXL8: view

Function for FBXL8 Gene

Molecular function for FBXL8 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19159283
genes like me logo Genes that share ontologies with FBXL8: view

Phenotypes for FBXL8 Gene

GenomeRNAi human phenotypes for FBXL8:
genes like me logo Genes that share phenotypes with FBXL8: view

Animal Model Products

CRISPR Products

miRNA for FBXL8 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL8 Gene

Localization for FBXL8 Gene

Subcellular locations from

Jensen Localization Image for FBXL8 Gene COMPARTMENTS Subcellular localization image for FBXL8 gene
Compartment Confidence
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL8 Gene

Pathways & Interactions for FBXL8 Gene

SuperPathways for FBXL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL8 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXL8 Gene

Drugs & Compounds for FBXL8 Gene

No Compound Related Data Available

Transcripts for FBXL8 Gene

mRNA/cDNA for FBXL8 Gene

Unigene Clusters for FBXL8 Gene

F-box and leucine-rich repeat protein 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - -
SP8: - -
SP9: - -

Relevant External Links for FBXL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL8 Gene

mRNA expression in normal human tissues for FBXL8 Gene

mRNA differential expression in normal tissues according to GTEx for FBXL8 Gene

This gene is overexpressed in Pituitary (x5.4).

Protein differential expression in normal tissues from HIPED for FBXL8 Gene

This gene is overexpressed in Salivary gland (8.5), Stomach (7.1), Peripheral blood mononuclear cells (6.7), Islet of Langerhans (6.6), and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL8 Gene

SOURCE GeneReport for Unigene cluster for FBXL8 Gene Hs.710714

genes like me logo Genes that share expression patterns with FBXL8: view

Protein tissue co-expression partners for FBXL8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FBXL8 Gene

Orthologs for FBXL8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXL8 35
  • 85.65 (n)
  • 86.36 (a)
FBXL8 36
  • 86 (a)
(Canis familiaris)
Mammalia FBXL8 35
  • 84.49 (n)
  • 84.49 (a)
-- 36
  • 84 (a)
(Mus musculus)
Mammalia Fbxl8 35
  • 79.71 (n)
  • 78.82 (a)
Fbxl8 16
Fbxl8 36
  • 79 (a)
(Pan troglodytes)
Mammalia FBXL8 35
  • 99.55 (n)
  • 99.2 (a)
FBXL8 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxl8 35
  • 77.48 (n)
  • 78.55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Gallus gallus)
Aves FBXL8 35
  • 52.33 (n)
  • 41.64 (a)
FBXL8 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
-- 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl8 35
  • 45.86 (n)
  • 36.67 (a)
(Danio rerio)
Actinopterygii fbxl8 35
  • 47.84 (n)
  • 40.22 (a)
fbxl8 36
  • 39 (a)
Species with no ortholog for FBXL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL8 Gene

Gene Tree for FBXL8 (if available)
Gene Tree for FBXL8 (if available)

Paralogs for FBXL8 Gene

Paralogs for FBXL8 Gene

genes like me logo Genes that share paralogs with FBXL8: view

Variants for FBXL8 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXL8 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680

Variation tolerance for FBXL8 Gene

Gene Damage Index Score: 3.27; 52.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FBXL8 Gene

Disorders for FBXL8 Gene

Relevant External Links for FBXL8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXL8: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL8 Gene

Publications for FBXL8 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 67
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67

Products for FBXL8 Gene

Sources for FBXL8 Gene

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