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FBXL7 Gene

protein-coding   GIFtS: 50
GCID: GC05P015553

F-Box And Leucine-Rich Repeat Protein 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 71 2 3     F-Box/LRR-Repeat Protein 72
FBL72 3 5     KIAA08403
FBL62 3     F-Box Protein FBL6/FBL73
F-Box Protein Fbl72     

External Ids:    HGNC: 136041   Entrez Gene: 231942   Ensembl: ENSG000001835807   OMIM: 6056565   UniProtKB: Q9UJT93   

Export aliases for FBXL7 gene to outside databases

Previous GC identifers: GC05P015490 GC05P015777


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXL7 Gene:
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the
F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one
of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in
phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on
the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins
that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known
protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily.
Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for FBXL7 Gene:
FBXL7 (F-box and leucine-rich repeat protein 7) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic
arrest (By similarity)

Gene Wiki entry for FBXL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL7 gene promoter:
         AML1a   POU2F1   POU2F1a   Hand1   NF-Y   CBF(2)   E47   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL7 promoter sequence
   Search Chromatin IP Primers for FBXL7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1   Ensembl cytogenetic band:  5p15.1   HGNC cytogenetic band: 5p15.1

FBXL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P015553:  view genomic region     (about GC identifiers)

Start:
15,500,305 bp from pter      End:
15,939,900 bp from pter
Size:
439,596 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 7  
Size: 491 amino acids; 54575 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1,
RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By
similarity)
Sequence caution: Sequence=BAA74863.2; Type=Erroneous initiation;
Secondary accessions: B9EGF1 O94926

Explore the universe of human proteins at neXtProt for FBXL7: NX_Q9UJT9

Explore proteomics data for FBXL7 at MOPED


See FBXL7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001265246.1  NP_036436.1  

ENSEMBL proteins: 
 ENSP00000423630   ENSP00000425184   ENSP00000329632  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FBXL: F-boxes / Leucine-rich repeats

2 InterPro protein domains:
 IPR006553 Leu-rich_rpt_Cys-con_subtyp
 IPR001810 F-box_dom

Graphical View of Domain Structure for InterPro Entry Q9UJT9

ProtoNet protein and cluster: Q9UJT9

UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9
Similarity: Belongs to the FBXL7 family
Similarity: Contains 1 F-box domain
Similarity: Contains 11 LRR (leucine-rich) repeats


Find genes that share domains with FBXL7           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FBXL7_HUMAN, Q9UJT9
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic
arrest (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity NAS10531035
GO:0005515protein binding ----
     
Find genes that share ontologies with FBXL7           About GenesLikeMe


Phenotypes:
     3 GenomeRNAi human phenotypes for FBXL7:
 Increased G1 DNA content  Synthetic lethal with Ras  Upregulation of NF-kappaB path 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FBXL7

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SwitchGear 3'UTR luciferase reporter plasmidFBXL7 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FBXL7_HUMAN, Q9UJT9: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity).
Note=Localizes to the centrosome during spindle formation (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton4
cytosol2
nucleus2
extracellular1
mitochondrion1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000151ubiquitin ligase complex NAS10531035
GO:0005737cytoplasm IEA--
GO:0005813centrosome ISS--
GO:0019005SCF ubiquitin ligase complex ISS--

Find genes that share ontologies with FBXL7           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9
Pathway: Protein modification; protein ubiquitination

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Interactions:

    Search GeneGlobe Interaction Network for FBXL7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for FBXL7 (Q9UJT93 ENSP000003296324) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

InteractantInteraction Details
GeneCardExternal ID(s)
SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
BTRCENSP000003592064STRING: ENSP00000359206
CCNFENSP000003802564STRING: ENSP00000380256
CUL1ENSP000003268044STRING: ENSP00000326804
FBXL15ENSP000002248624STRING: ENSP00000224862
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000086G2/M transition of mitotic cell cycle ISS--
GO:0006511ubiquitin-dependent protein catabolic process NAS10531035
GO:0007067mitosis ISS--
GO:0008283cell proliferation ISS--
GO:0016567protein ubiquitination ISS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for FBXL7



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for FBXL7 gene (2 alternative transcripts): 
NM_001278317.1  NM_012304.4  

Unigene Cluster for FBXL7:

F-box and leucine-rich repeat protein 7
Hs.433057  [show with all ESTs]
Unigene Representative Sequence: AB020647
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000504595(uc003jfn.1) ENST00000510662 ENST00000329673
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Additional mRNA sequence: 

AB020647.2 AF174593.1 AF199356.1 AK021671.1 AK309585.1 BC050571.1 BC075061.2 BC136424.1 

2 DOTS entries:

DT.443041  DT.439685 

Selected AceView cDNA sequences (see all 93):

AI191838 AF174593 BM724567 CD672860 AI803941 AK021671 BU741721 BC075061 
BM717743 AU118611 N53243 AA551022 AI192791 CD674601 BU627383 BU633031 
AI480168 NM_012304 CA430121 AB020647 N55926 BC050571 AI093061 AI350723 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FBXL7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGACAAAGCT
FBXL7 Expression
About this image


FBXL7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
 
 Testis (Reproductive System)
         Sertoli cells Seminiferous Tubules
 
 Ovary (Reproductive System)
FBXL7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FBXL7 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.433057
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL7 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fbxl71 , 5 F-box and leucine-rich repeat protein 71, 5 89.61(n)1
98.37(a)1
  15 (9.87 cM)5
4489871  NM_176959.31  NP_795933.21 
 265430845 
chicken
(Gallus gallus)
Aves FBXL71 F-box and leucine-rich repeat protein 7 85.41(n)
93.25(a)
  428492  XM_004935103.1  XP_004935160.1 
lizard
(Anolis carolinensis)
Reptilia FBXL76
F-box and leucine-rich repeat protein 7
91(a)
1 ↔ 1
4(60342080-60539586)
tropical clawed frog
(Xenopus tropicalis)
Amphibia fbxl71 F-box and leucine-rich repeat protein 7 78.5(n)
93.47(a)
  100487770  XM_002933123.2  XP_002933169.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1583461 zgc:158346 75.75(n)
82.79(a)
  569430  NM_001080042.1  NP_001073511.1 
fruit fly
(Drosophila melanogaster)
Insecta CG42211 , 3 CG42211 49(a)3
58.65(n)1
50.54(a)1
  89A83
419351  NM_142255.31  NP_650512.11 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR16
F-box protein component of the SCF ubiquitin-ligas...
8(a)
1 → many
X(590872-594327) YJR090C


ENSEMBL Gene Tree for FBXL7 (if available)
TreeFam Gene Tree for FBXL7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FBXL7 gene
FBXL22  FBXL172  FBXL202  ENSG000002371022  FBXL132  FBXL162  LRRC292  FBXL152  
FBXL142  FBXL42  
2 SIMAP similar genes for FBXL7 using alignment to 4 protein entries:     FBXL7_HUMAN (see all proteins):
FBXL2    FBXL20

Find genes that share paralogs with FBXL7           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for FBXL7 (see all 8569)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1827520891,2
--15498329(+) TTTCAA/TATATG 1 -- us2k10--------
rs756301311,2
C--15498397(+) AGACCA/GTGCTA 1 -- us2k10--------
rs788070581,2
C,F--15498578(+) ATCACA/GGGAGT 1 -- us2k13Minor allele frequency- G:0.32CSA WA 120
rs1137530051,2
C,F--15498711(+) GAGCTT/CGGATC 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
rs1127367981,2
F--15498801(+) AATACA/GGACCA 1 -- us2k12Minor allele frequency- G:0.06CSA WA 120
rs1874418161,2
--15498862(+) TTCTAA/GATTGG 1 -- us2k10--------
rs352917091,2
C--15498918(+) TTTTGA/GTATCT 1 -- us2k11Minor allele frequency- G:0.00NA 2
rs774169501,2
C,F--15499249(+) GTTAAA/GTCACT 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs1921892191,2
--15499269(+) TGCATG/TTGGTC 1 -- us2k10--------
rs1134528721,2
C,F--15499502(+) TTAGGG/ATGTAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2

HapMap Linkage Disequilibrium report for FBXL7 (15500305 - 15750305 bp, first 250kb of FBXL7)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for FBXL7 (see all 41):    About this table    
Variant IDTypeSubtypePubMed ID
esv2021602CNV Deletion18987734
esv2672541CNV Deletion23128226
esv2729825CNV Deletion23290073
esv2671030CNV Deletion23128226
esv2395102CNV Deletion18987734
esv2729824CNV Deletion23290073
esv2656471CNV Deletion23128226
esv2729826CNV Deletion23290073
esv2517640CNV Deletion19546169
esv2729827CNV Deletion23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605656    OMIM disorders: --


Find genes that share disorders with FBXL7           About GenesLikeMe

Genetic Association Database (GAD): FBXL7
Human Genome Epidemiology (HuGE) Navigator: FBXL7 (2 documents)

Export disorders for FBXL7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FBXL7 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with FBXL7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 20418484)1, 4 Wang X....Couch F.J. (Hum. Mol. Genet. 2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
  7. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (Genomics 2000)
  8. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)1 Tan M.K....Harper J.W. (Mol. Cell 2013)
  9. The genetic architecture of economic and political preferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23194 HGNC: 13604 AceView: FBXL7 Ensembl:ENSG00000183580 euGenes: HUgn23194
ECgene: FBXL7 H-InvDB: FBXL7

(According to HUGE)
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HUGE: KIAA0840

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FBXL7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FBXL7 gene:
Search GeneIP for patents involving FBXL7

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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