Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL7 Gene

protein-coding   GIFtS: 52
GCID: GC05P015553

F-Box And Leucine-Rich Repeat Protein 7

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And Leucine-Rich Repeat Protein 71 2 3     F-Box/LRR-Repeat Protein 72
FBL72 3 5     KIAA08403
FBL62 3     F-Box Protein FBL6/FBL73
F-Box Protein Fbl72     

External Ids:    HGNC: 136041   Entrez Gene: 231942   Ensembl: ENSG000001835807   OMIM: 6056565   UniProtKB: Q9UJT93   

Export aliases for FBXL7 gene to outside databases

Previous GC identifers: GC05P015490 GC05P015777


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXL7 Gene:
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the
F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one
of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in
phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on
the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins
that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known
protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily.
Alternative splicing results in multiple transcript variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for FBXL7 Gene: 
FBXL7 (F-box and leucine-rich repeat protein 7) is a protein-coding gene. Diseases associated with FBXL7 include breast cancer. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXL17.

UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic
arrest (By similarity)

Gene Wiki entry for FBXL7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL7 gene promoter:
         AML1a   POU2F1   POU2F1a   Hand1   NF-Y   CBF(2)   E47   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL7 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.1   Ensembl cytogenetic band:  5p15.1   HGNC cytogenetic band: 5p15.1

FBXL7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P015553:  view genomic region     (about GC identifiers)

Start:
15,500,305 bp from pter      End:
15,939,900 bp from pter
Size:
439,596 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 7  
Size: 491 amino acids; 54575 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1,
RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By
similarity)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity).
Note=Localizes to the centrosome during spindle formation (By similarity)
Sequence caution: Sequence=BAA74863.2; Type=Erroneous initiation;
Secondary accessions: B9EGF1 O94926

Explore the universe of human proteins at neXtProt for FBXL7: NX_Q9UJT9

Explore proteomics data for FBXL7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJT9

  • FBXL7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXL7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265246.1  NP_036436.1  

    ENSEMBL proteins: 
     ENSP00000423630   ENSP00000425184   ENSP00000329632  

    Human Recombinant Protein Products for FBXL7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBXL7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FBXL7
    GenScript Custom Purified and Recombinant Proteins Services for FBXL7
    Novus Biologicals FBXL7 Proteins
    Novus Biologicals FBXL7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXL7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome ISS--
    GO:0019005SCF ubiquitin ligase complex ISS--

    FBXL7 for ontologies           About GeneDecksing



    FBXL7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXL7
    GenScript Custom Superior Antibodies Services for FBXL7
    Novus Biologicals FBXL7 Antibodies
    Abcam antibodies for FBXL7
    Cloud-Clone Corp. Antibodies for FBXL7 
    ThermoFisher Antibody for FBXL7
    LSBio Antibodies in human, mouse, rat for FBXL7 

    Assay Products for FBXL7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXL7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXL7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXL7 
    Cloud-Clone Corp. CLIAs for FBXL7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXL: F-boxes / Leucine-rich repeats

    2 InterPro protein domains:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9UJT9

    ProtoNet protein and cluster: Q9UJT9

    UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9
    Similarity: Belongs to the FBXL7 family
    Similarity: Contains 1 F-box domain
    Similarity: Contains 11 LRR (leucine-rich) repeats


    FBXL7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL7_HUMAN, Q9UJT9
    Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic
    arrest (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding ----
         
    FBXL7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXL7:
     Increased G1 DNA content  Synthetic lethal with Ras  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXL7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXL7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXL7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL7
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXL7 (see all 27):
    hsa-miR-576-3p hsa-miR-623 hsa-miR-137 hsa-miR-539 hsa-miR-139-5p hsa-miR-578 hsa-miR-558 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidFBXL7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXL7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXL7
    Sirion Biotech Customized adenovirus for overexpression of FBXL7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FBXL7 (see all 7)
    OriGene ORF clones in mouse, rat for FBXL7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXL7 (NM_012304)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL7
    Sirion Biotech Customized lentivirus for stable overexpression of FBXL7 
                         Customized lentivirus expression plasmids for stable overexpression of FBXL7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXL7
    Search LifeMap BioReagents cell lines for FBXL7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: FBXL7_HUMAN, Q9UJT9
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for FBXL7 (Q9UJT93 ENSP000003296324) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    BTRCENSP000003592064STRING: ENSP00000359206
    CCNFENSP000003802564STRING: ENSP00000380256
    CUL1ENSP000003268044STRING: ENSP00000326804
    FBXL15ENSP000002248624STRING: ENSP00000224862
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle ISS--
    GO:0006511ubiquitin-dependent protein catabolic process NAS10531035
    GO:0007067mitosis ISS--
    GO:0008283cell proliferation ISS--
    GO:0016567protein ubiquitination ISS--

    FBXL7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXL7

    Search CenterWatch for drugs/clinical trials and news about FBXL7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXL7 gene (2 alternative transcripts): 
    NM_001278317.1  NM_012304.4  

    Unigene Cluster for FBXL7:

    F-box and leucine-rich repeat protein 7
    Hs.433057  [show with all ESTs]
    Unigene Representative Sequence: AB020647
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504595(uc003jfn.1) ENST00000510662 ENST00000329673
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL7
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXL7 (see all 27):
    hsa-miR-576-3p hsa-miR-623 hsa-miR-137 hsa-miR-539 hsa-miR-139-5p hsa-miR-578 hsa-miR-558 hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidFBXL7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXL7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL7
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXL7 (see all 7)
    OriGene ORF clones in mouse, rat for FBXL7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXL7 (NM_012304)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL7
    Sirion Biotech Customized lentivirus for stable overexpression of FBXL7 
                         Customized lentivirus expression plasmids for stable overexpression of FBXL7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXL7
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL7

    Additional mRNA sequence: 

    AB020647.2 AF174593.1 AF199356.1 AK021671.1 AK309585.1 BC050571.1 BC075061.2 BC136424.1 

    2 DOTS entries:

    DT.443041  DT.439685 

    24/93 AceView cDNA sequences (see all 93):

    CD671576 AI191838 AF174593 BM724567 CD672860 AI803941 AK021671 BU741721 
    BC075061 BM717743 AU118611 N53243 AA551022 AI192791 CD674601 BU627383 
    BU633031 AI480168 NM_012304 CA430121 AB020647 N55926 BC050571 AI093061 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL7 expression in normal human tissues (normalized intensities)      FBXL7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACAAAGCT
    FBXL7 Expression
    About this image


    FBXL7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             myometrium   
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Ovary (Reproductive System)

    See FBXL7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL7

    SOURCE GeneReport for Unigene cluster: Hs.433057
        SABiosciences Custom PCR Arrays for FBXL7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXL7
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXL7 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl71 , 5 F-box and leucine-rich repeat protein 71, 5 89.61(n)1
    98.37(a)1
      15 (9.87 cM)5
    4489871  NM_176959.31  NP_795933.21 
     265430845 
    chicken
    (Gallus gallus)
    Aves FBXL71 F-box and leucine-rich repeat protein 7 86.22(n)
    94.5(a)
      428492  XM_426048.3  XP_426048.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL76
    Uncharacterized protein
    91(a)
    1 ↔ 1
    4(60342080-60539586)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1583461 zgc:158346 75.39(n)
    82.21(a)
      569430  NM_001080042.1  NP_001073511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG42211 , 3 CG42211 49(a)3
    55(n)1
    46.44(a)1
      89A83
    419351  NM_142255.21  NP_650512.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRR16
    F-box protein component of the SCF ubiquitin-ligas...
    7(a)
    1 → many
    X(590872-594327)


    ENSEMBL Gene Tree for FBXL7 (if available)
    TreeFam Gene Tree for FBXL7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXL7 gene
    FBXL172  FBXL22  FBXL202  ENSG000002371022  FBXL132  FBXL162  LRRC292  FBXL152  
    FBXL42  FBXL142  
    2 SIMAP similar genes for FBXL7 using alignment to 4 protein entries:     FBXL7_HUMAN (see all proteins):
    FBXL2    FBXL20

    FBXL7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8569 SNPs in FBXL7 are shown (see all 8569)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827520891,2
    --15498329(+) TTTCAA/TATATG 1 -- us2k10--------
    rs756301311,2
    C--15498397(+) AGACCA/GTGCTA 1 -- us2k10--------
    rs788070581,2
    C,F--15498578(+) ATCACA/GGGAGT 1 -- us2k13Minor allele frequency- G:0.32CSA WA 120
    rs1137530051,2
    C,F--15498711(+) GAGCTT/CGGATC 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1127367981,2
    F--15498801(+) AATACA/GGACCA 1 -- us2k12Minor allele frequency- G:0.06CSA WA 120
    rs1874418161,2
    --15498862(+) TTCTAA/GATTGG 1 -- us2k10--------
    rs352917091,2
    C--15498918(+) TTTTGA/GTATCT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs774169501,2
    C,F--15499249(+) GTTAAA/GTCACT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1921892191,2
    --15499269(+) TGCATG/TTGGTC 1 -- us2k10--------
    rs1134528721,2
    C,F--15499502(+) TTAGGG/ATGTAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for FBXL7 (15500305 - 15750305 bp, first 250kb of FBXL7)

    Structural Variations
         Database of Genomic Variants (DGV) 10/41 variations for FBXL7 (see all 41):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2021602CNV Deletion18987734
    esv2672541CNV Deletion23128226
    esv2729825CNV Deletion23290073
    esv2671030CNV Deletion23128226
    esv2395102CNV Deletion18987734
    esv2729824CNV Deletion23290073
    esv2656471CNV Deletion23128226
    esv2729826CNV Deletion23290073
    esv2517640CNV Deletion19546169
    esv2729827CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXL7
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXL7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605656    OMIM disorders: --

    2 diseases for FBXL7:    About MalaCards
    breast cancer    


    FBXL7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXL7
    Human Genome Epidemiology (HuGE) Navigator: FBXL7 (2 documents)

    Export disorders for FBXL7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL7 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with FBXL7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Common variants associated with breast cancer in geno me-wide association studies are modifiers of breast cancer risk in BRCA1 and BR CA2 mutation carriers. (PubMed id 20418484)1, 4 Wang X....Couch F.J. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
    8. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    10. Novel E3 ligase component FBXL7 ubiquitinates and degr ades Aurora A, causing mitotic arrest. (PubMed id 22306998)1 Coon T.A....Chen B.B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23194 HGNC: 13604 AceView: FBXL7 Ensembl:ENSG00000183580 euGenes: HUgn23194
    ECgene: FBXL7 H-InvDB: FBXL7

    (According to HUGE)
    About This Section
    HUGE: KIAA0840

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXL7 gene:
    Search GeneIP for patents involving FBXL7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXL7  
     OriGene qPCR primer pairs and template standards for FBXL7   OriGene Protein Over-expression Lysate for FBXL7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXL7  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXL7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXL7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXL7   OriGene Custom Protein Services for FBXL7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXL7
     QIAGEN SeqTarget long-range PCR primers for resequencing FBXL7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL7
     GenScript Custom Purified and Recombinant Proteins Services for FBXL7 GenScript cDNA clones with any tag delivered in your preferred vector for FBXL7
     GenScript Custom Assay Services for FBXL7 GenScript Custom Superior Antibodies Services for FBXL7
     GenScript Custom overexpressing Cell Line Services for FBXL7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXL7 promoter
     Search Chromatin IP Primers for FBXL7
     RT2 qPCR Primer Assay in human, mouse, rat FBXL7
     Search GNC Networks for FBXL7
     SABiosciences Custom PCR Arrays for FBXL7
     Search Tocris compounds for FBXL7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FBXL7 antibodies
     FBXL7 proteins
     FBXL7 lysates
     Antibodies for FBXL7
     See all of Abcam's Antibodies, Kits and Proteins for FBXL7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FBXL7
     Antibodies for FBXL7
     ELISAs for FBXL7
     CLIAs for FBXL7
     Search LifeMap BioReagents cell lines for FBXL7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL7
     SwitchGear 3'UTR luciferase reporter plasmids for FBXL7
     SwitchGear Promoter luciferase reporter plasmids for FBXL7
     ThermoFisher Antibody for FBXL7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXL7
    Customized:
     lentivirus for stable overexpression of FBXL7
     lentivirus expression plasmids for stable overexpression of FBXL7
     adenovirus for overexpression of FBXL7
     LSBio Antibodies in human, mouse, rat for FBXL7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXL7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4