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Aliases for FBXL7 Gene

Aliases for FBXL7 Gene

  • F-Box And Leucine-Rich Repeat Protein 7 2 3 4
  • FBL7 3 4 6
  • FBL6 3 4
  • F-Box/LRR-Repeat Protein 7 3
  • F-Box Protein FBL6/FBL7 4
  • F-Box Protein Fbl7 3
  • KIAA0840 4

External Ids for FBXL7 Gene

Previous GeneCards Identifiers for FBXL7 Gene

  • GC05P015490
  • GC05P015777

Summaries for FBXL7 Gene

Entrez Gene Summary for FBXL7 Gene

  • This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for FBXL7 Gene

FBXL7 (F-Box And Leucine-Rich Repeat Protein 7) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL7 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Wiki entry for FBXL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL7 Gene

Genomics for FBXL7 Gene

Regulatory Elements for FBXL7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL7 Gene

15,500,196 bp from pter
15,939,796 bp from pter
439,601 bases
Plus strand

Genomic View for FBXL7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL7 Gene

Proteins for FBXL7 Gene

  • Protein details for FBXL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 7
    Protein Accession:
    Secondary Accessions:
    • B9EGF1
    • D6RDY7
    • O94926

    Protein attributes for FBXL7 Gene

    491 amino acids
    Molecular mass:
    54575 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).
    • Sequence=BAA74863.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL7 Gene


neXtProt entry for FBXL7 Gene

Proteomics data for FBXL7 Gene at MOPED

Post-translational modifications for FBXL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL7 Gene

Antibody Products

No data available for DME Specific Peptides for FBXL7 Gene

Domains for FBXL7 Gene

Gene Families for FBXL7 Gene

Protein Domains for FBXL7 Gene

Suggested Antigen Peptide Sequences for FBXL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Belongs to the FBXL7 family.
  • Contains 11 LRR (leucine-rich) repeats.
  • Contains 1 F-box domain.
  • Belongs to the FBXL7 family.
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL7: view

Function for FBXL7 Gene

Molecular function for FBXL7 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Ontology (GO) - Molecular Function for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL7: view
genes like me logo Genes that share phenotypes with FBXL7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL7 Gene

Localization for FBXL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FBXL7 Gene COMPARTMENTS Subcellular localization image for FBXL7 gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0019005 SCF ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with FBXL7: view

Pathways for FBXL7 Gene

SuperPathways for FBXL7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9UJT9-FBXL7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle ISS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0007067 mitotic nuclear division ISS --
GO:0008283 cell proliferation ISS --
GO:0016567 protein ubiquitination ISS --
genes like me logo Genes that share ontologies with FBXL7: view

No data available for Pathways by source for FBXL7 Gene

Transcripts for FBXL7 Gene

Unigene Clusters for FBXL7 Gene

F-box and leucine-rich repeat protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL7 Gene

No ASD Table

Relevant External Links for FBXL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL7 Gene

mRNA expression in normal human tissues for FBXL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FBXL7 Gene

This gene is overexpressed in Platelet (65.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXL7 Gene

SOURCE GeneReport for Unigene cluster for FBXL7 Gene Hs.433057

genes like me logo Genes that share expressions with FBXL7: view

Expression partners for FBXL7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL7 Gene

Orthologs for FBXL7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXL7 35
  • 93.41 (n)
  • 97.76 (a)
FBXL7 36
  • 98 (a)
(Canis familiaris)
Mammalia FBXL7 35
  • 85.7 (n)
  • 87.36 (a)
FBXL7 36
  • 87 (a)
(Mus musculus)
Mammalia Fbxl7 35
  • 89.61 (n)
  • 98.37 (a)
Fbxl7 16
Fbxl7 36
  • 98 (a)
(Pan troglodytes)
Mammalia FBXL7 35
  • 99.8 (n)
  • 100 (a)
FBXL7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxl7 35
  • 89.07 (n)
  • 98.57 (a)
(Monodelphis domestica)
Mammalia FBXL7 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL7 36
  • 95 (a)
(Gallus gallus)
Aves FBXL7 35
  • 85.41 (n)
  • 93.25 (a)
FBXL7 36
  • 95 (a)
(Anolis carolinensis)
Reptilia FBXL7 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl7 35
  • 78.5 (n)
  • 93.47 (a)
(Danio rerio)
Actinopterygii zgc:158346 35
  • 75.75 (n)
  • 82.79 (a)
FBXL7 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4221 37
  • 49 (a)
CG4221 35
  • 58.65 (n)
  • 50.54 (a)
CG4221 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003285 35
  • 56.94 (n)
  • 49.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
Species with no ortholog for FBXL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL7 Gene

Gene Tree for FBXL7 (if available)
Gene Tree for FBXL7 (if available)

Paralogs for FBXL7 Gene

Paralogs for FBXL7 Gene

(2) SIMAP similar genes for FBXL7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL7: view

Variants for FBXL7 Gene

Sequence variations from dbSNP and Humsavar for FBXL7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs4484432 -- 15,739,667(+) ATGGG(G/T)TTCTT intron-variant
rs4489062 -- 15,745,531(+) tgaaa(A/T)aaagt intron-variant
rs4505949 -- 15,706,862(+) GCAGG(C/T)TGTCT intron-variant
rs4701636 -- 15,645,506(+) TCTTA(C/G)GTTTC intron-variant
rs4701635 -- 15,632,283(+) CTAGa(A/G)aattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL7 Gene

Variant ID Type Subtype PubMed ID
nsv516929 CNV Gain+Loss 19592680
esv2729824 CNV Deletion 23290073
nsv4730 CNV Insertion 18451855
nsv830214 CNV Gain 17160897
nsv4732 CNV Loss 18451855
esv2671030 CNV Deletion 23128226
nsv4733 CNV Insertion 18451855
nsv880755 CNV Gain 21882294
nsv461983 CNV Loss 19166990
essv11607 CNV CNV 17122850
esv1150 CNV CNV 17122850
essv6409 CNV CNV 17122850
dgv1759e1 CNV Complex 17122850
dgv1760e1 CNV Complex 17122850
essv19140 CNV CNV 17122850
dgv1761e1 CNV Complex 17122850
dgv1762e1 CNV Complex 17122850
essv23288 CNV CNV 17122850
nsv10671 CNV Loss 18304495
nsv442939 CNV CNV 18776908
essv11383 CNV CNV 17122850
esv2421516 CNV Deletion 20811451
dgv1763e1 CNV Complex 17122850
esv23849 CNV Loss 19812545
nsv818319 CNV Loss 17921354
esv2729825 CNV Deletion 23290073
nsv471736 CNV Loss 16327809
esv2656471 CNV Deletion 23128226
nsv823014 CNV Loss 20364138
nsv514291 CNV Loss 21397061
nsv461985 CNV Loss 19166990
nsv818320 CNV Loss 17921354
nsv4734 CNV Insertion 18451855
esv2729826 CNV Deletion 23290073
esv2395102 CNV Deletion 18987734
nsv830216 CNV Loss 17160897
esv2517640 CNV Deletion 19546169
esv2021602 CNV Deletion 18987734
esv2672541 CNV Deletion 23128226
nsv4735 CNV Loss 18451855
esv2729827 CNV Deletion 23290073

Relevant External Links for FBXL7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL7 Gene

Disorders for FBXL7 Gene

Relevant External Links for FBXL7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FBXL7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FBXL7 Gene

Publications for FBXL7 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  3. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PMID: 10945468) Ilyin G.P. … Guguen-Guillouzo C. (Genomics 2000) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for FBXL7 Gene

Sources for FBXL7 Gene

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