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Aliases for FBXL7 Gene

Aliases for FBXL7 Gene

  • F-Box And Leucine Rich Repeat Protein 7 2 3 5
  • FBL6 3 4
  • FBL7 3 4
  • F-Box And Leucine-Rich Repeat Protein 7 4
  • F-Box/LRR-Repeat Protein 7 3
  • F-Box Protein FBL6/FBL7 4
  • F-Box Protein Fbl7 3
  • KIAA0840 4

External Ids for FBXL7 Gene

Previous GeneCards Identifiers for FBXL7 Gene

  • GC05P015490
  • GC05P015777

Summaries for FBXL7 Gene

Entrez Gene Summary for FBXL7 Gene

  • This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for FBXL7 Gene

FBXL7 (F-Box And Leucine Rich Repeat Protein 7) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot for FBXL7 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Wiki entry for FBXL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL7 Gene

Genomics for FBXL7 Gene

Regulatory Elements for FBXL7 Gene

Enhancers for FBXL7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F015693 1.2 Ensembl ENCODE 10.6 +194.5 194496 3.0 CTCF POLR2A SMARCA4 FBXL7 GC05P015701 GC05P015675
GH05F015719 0.9 Ensembl ENCODE 10 +219.2 219226 1.4 FBXL7 GC05M015718 GC05P015701
GH05F016460 0.5 ENCODE 9.8 +964.3 964304 7.8 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC101929505 FBXL7 GC05P016465 GC05P016453
GH05F015794 0.9 Ensembl ENCODE 5.4 +294.6 294643 0.9 CTCF RAD21 FBXL7 GC05P015792 GC05P015799
GH05F015807 0.5 Ensembl 4.8 +307.8 307837 0.4 CTCF REST RAD21 FBXL7 GC05P015799 PIR33607
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FBXL7 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001276028 835 3201 CTCF PKNOX1 TEAD4 ZIC2 RAD21 E2F1 POLR2A SCRT2 MAFK EGR2

Genomic Location for FBXL7 Gene

Chromosome:
5
Start:
15,500,165 bp from pter
End:
15,939,796 bp from pter
Size:
439,632 bases
Orientation:
Plus strand

Genomic View for FBXL7 Gene

Genes around FBXL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL7 Gene

Proteins for FBXL7 Gene

  • Protein details for FBXL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT9-FBXL7_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 7
    Protein Accession:
    Q9UJT9
    Secondary Accessions:
    • B9EGF1
    • D6RDY7
    • O94926

    Protein attributes for FBXL7 Gene

    Size:
    491 amino acids
    Molecular mass:
    54575 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).
    SequenceCaution:
    • Sequence=BAA74863.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL7 Gene

Post-translational modifications for FBXL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL7 Gene

No data available for DME Specific Peptides for FBXL7 Gene

Domains & Families for FBXL7 Gene

Gene Families for FBXL7 Gene

Protein Domains for FBXL7 Gene

Suggested Antigen Peptide Sequences for FBXL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJT9

UniProtKB/Swiss-Prot:

FBXL7_HUMAN :
  • Contains 1 F-box domain.
  • Belongs to the FBXL7 family.
  • Contains 11 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Family:
  • Belongs to the FBXL7 family.
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL7: view

Function for FBXL7 Gene

Molecular function for FBXL7 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Ontology (GO) - Molecular Function for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXL7: view
genes like me logo Genes that share phenotypes with FBXL7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL7 Gene

Localization for FBXL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL7 Gene COMPARTMENTS Subcellular localization image for FBXL7 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FBXL7: view

Pathways & Interactions for FBXL7 Gene

genes like me logo Genes that share pathways with FBXL7: view

UniProtKB/Swiss-Prot Q9UJT9-FBXL7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle ISS --
GO:0006511 ubiquitin-dependent protein catabolic process NAS 10531035
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division ISS --
GO:0008283 cell proliferation ISS --
genes like me logo Genes that share ontologies with FBXL7: view

No data available for SIGNOR curated interactions for FBXL7 Gene

Transcripts for FBXL7 Gene

Unigene Clusters for FBXL7 Gene

F-box and leucine-rich repeat protein 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL7 Gene

No ASD Table

Relevant External Links for FBXL7 Gene

GeneLoc Exon Structure for
FBXL7
ECgene alternative splicing isoforms for
FBXL7

Expression for FBXL7 Gene

mRNA expression in normal human tissues for FBXL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL7 Gene

This gene is overexpressed in Platelet (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL7 Gene



Protein tissue co-expression partners for FBXL7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL7 Gene:

FBXL7

SOURCE GeneReport for Unigene cluster for FBXL7 Gene:

Hs.433057
genes like me logo Genes that share expression patterns with FBXL7: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL7 Gene

Orthologs for FBXL7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL7 34 35
  • 99.8 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL7 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL7 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL7 34 35
  • 93.41 (n)
mouse
(Mus musculus)
Mammalia Fbxl7 34 16 35
  • 89.61 (n)
rat
(Rattus norvegicus)
Mammalia Fbxl7 34
  • 89.07 (n)
dog
(Canis familiaris)
Mammalia FBXL7 34 35
  • 85.7 (n)
chicken
(Gallus gallus)
Aves FBXL7 34 35
  • 85.41 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL7 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl7 34
  • 78.5 (n)
zebrafish
(Danio rerio)
Actinopterygii FBXL7 35
  • 82 (a)
OneToOne
zgc:158346 34
  • 75.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4221 36 34 35
  • 58.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003285 34
  • 56.94 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
ManyToMany
Species where no ortholog for FBXL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL7 Gene

ENSEMBL:
Gene Tree for FBXL7 (if available)
TreeFam:
Gene Tree for FBXL7 (if available)

Paralogs for FBXL7 Gene

Paralogs for FBXL7 Gene

(2) SIMAP similar genes for FBXL7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL7: view

Variants for FBXL7 Gene

Sequence variations from dbSNP and Humsavar for FBXL7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10037317 -- 15,593,275(+) TCCCA(A/G)CACTT intron-variant
rs10037873 -- 15,752,216(+) ATATA(A/C/G)CTACG intron-variant
rs10038131 -- 15,619,006(+) tcatg(C/T)gcccc intron-variant
rs10039391 -- 15,729,780(+) CTGTG(C/T)GTCAG intron-variant
rs10041362 -- 15,531,204(+) atagt(A/G)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL7 Gene

Variant ID Type Subtype PubMed ID
dgv1582e212 CNV loss 25503493
dgv3047n106 CNV deletion 24896259
dgv55e213 CNV loss 24956385
dgv9610n54 CNV loss 21841781
dgv9611n54 CNV loss 21841781
dgv9612n54 CNV loss 21841781
dgv9613n54 CNV loss 21841781
dgv9614n54 CNV loss 21841781
dgv9615n54 CNV loss 21841781
dgv9616n54 CNV loss 21841781
esv2021602 CNV deletion 18987734
esv23849 CNV loss 19812545
esv2395102 CNV deletion 18987734
esv2421516 CNV deletion 20811451
esv2517640 CNV deletion 19546169
esv2656471 CNV deletion 23128226
esv2671030 CNV deletion 23128226
esv2672541 CNV deletion 23128226
esv2729824 CNV deletion 23290073
esv2729825 CNV deletion 23290073
esv2729826 CNV deletion 23290073
esv2729827 CNV deletion 23290073
esv2759327 CNV gain+loss 17122850
esv2760924 CNV loss 21179565
esv2763894 CNV loss 21179565
esv3343086 CNV insertion 20981092
esv3565569 CNV deletion 23714750
esv3570003 CNV loss 25503493
esv3570006 CNV loss 25503493
esv3604112 CNV loss 21293372
esv3604114 CNV loss 21293372
esv3604115 CNV loss 21293372
esv3604116 CNV loss 21293372
esv3604117 CNV loss 21293372
esv3604118 CNV loss 21293372
esv3894139 CNV loss 25118596
esv3894140 CNV loss 25118596
nsv1031483 CNV gain 25217958
nsv10671 CNV loss 18304495
nsv1072537 CNV deletion 25765185
nsv1074816 CNV deletion 25765185
nsv1121642 CNV deletion 24896259
nsv1144102 CNV deletion 24896259
nsv1161212 CNV deletion 26073780
nsv1161213 CNV deletion 26073780
nsv1161214 CNV deletion 26073780
nsv1161215 CNV deletion 26073780
nsv442939 CNV loss 18776908
nsv461983 CNV loss 19166990
nsv461985 CNV loss 19166990
nsv471736 CNV loss 16327809
nsv4730 CNV insertion 18451855
nsv4732 CNV deletion 18451855
nsv4733 CNV insertion 18451855
nsv4734 CNV insertion 18451855
nsv4735 CNV deletion 18451855
nsv475636 CNV novel sequence insertion 20440878
nsv514291 CNV loss 21397061
nsv516929 CNV gain+loss 19592680
nsv597265 CNV loss 21841781
nsv597270 CNV loss 21841781
nsv597292 CNV gain 21841781
nsv818319 CNV loss 17921354
nsv818320 CNV loss 17921354
nsv823014 CNV loss 20364138
nsv830214 CNV gain 17160897
nsv830216 CNV loss 17160897

Variation tolerance for FBXL7 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL7 Gene

Disorders for FBXL7 Gene

Relevant External Links for FBXL7

Genetic Association Database (GAD)
FBXL7
Human Genome Epidemiology (HuGE) Navigator
FBXL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL7

No disorders were found for FBXL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL7 Gene

Publications for FBXL7 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PMID: 20418484) Wang X. … Couch F.J. (Hum. Mol. Genet. 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FBXL7 Gene

Sources for FBXL7 Gene

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