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Aliases for FBXL7 Gene

Aliases for FBXL7 Gene

  • F-Box And Leucine-Rich Repeat Protein 7 2 3 4 5
  • FBL6 3 4
  • FBL7 3 4
  • F-Box Protein FBL6/FBL7 4
  • F-Box Protein Fbl7 3
  • KIAA0840 4

External Ids for FBXL7 Gene

Previous GeneCards Identifiers for FBXL7 Gene

  • GC05P015490
  • GC05P015777

Summaries for FBXL7 Gene

Entrez Gene Summary for FBXL7 Gene

  • This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for FBXL7 Gene

FBXL7 (F-Box And Leucine-Rich Repeat Protein 7) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL7 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Wiki entry for FBXL7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL7 Gene

Genomics for FBXL7 Gene

Regulatory Elements for FBXL7 Gene

Enhancers for FBXL7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXL7 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL7 Gene

15,500,165 bp from pter
15,939,796 bp from pter
439,632 bases
Plus strand

Genomic View for FBXL7 Gene

Genes around FBXL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL7 Gene

Proteins for FBXL7 Gene

  • Protein details for FBXL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 7
    Protein Accession:
    Secondary Accessions:
    • B9EGF1
    • D6RDY7
    • O94926

    Protein attributes for FBXL7 Gene

    491 amino acids
    Molecular mass:
    54575 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase (By similarity).
    • Sequence=BAA74863.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL7 Gene


neXtProt entry for FBXL7 Gene

Proteomics data for FBXL7 Gene at MOPED

Post-translational modifications for FBXL7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL7 Gene

No data available for DME Specific Peptides for FBXL7 Gene

Domains & Families for FBXL7 Gene

Gene Families for FBXL7 Gene

Protein Domains for FBXL7 Gene

Suggested Antigen Peptide Sequences for FBXL7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Belongs to the FBXL7 family.
  • Contains 11 LRR (leucine-rich) repeats.
  • Contains 1 F-box domain.
  • Belongs to the FBXL7 family.
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL7: view

Function for FBXL7 Gene

Molecular function for FBXL7 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.

Gene Ontology (GO) - Molecular Function for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
genes like me logo Genes that share ontologies with FBXL7: view
genes like me logo Genes that share phenotypes with FBXL7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL7 Gene

Localization for FBXL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL7 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FBXL7 Gene COMPARTMENTS Subcellular localization image for FBXL7 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FBXL7 Gene

Pathways & Interactions for FBXL7 Gene

SuperPathways for FBXL7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9UJT9-FBXL7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle ISS --
GO:0016567 protein ubiquitination ISS --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FBXL7: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL7 Gene

Drugs & Compounds for FBXL7 Gene

No Compound Related Data Available

Transcripts for FBXL7 Gene

Unigene Clusters for FBXL7 Gene

F-box and leucine-rich repeat protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL7 Gene

No ASD Table

Relevant External Links for FBXL7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL7 Gene

mRNA expression in normal human tissues for FBXL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL7 Gene

This gene is overexpressed in Platelet (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL7 Gene

SOURCE GeneReport for Unigene cluster for FBXL7 Gene Hs.433057

genes like me logo Genes that share expression patterns with FBXL7: view

Protein tissue co-expression partners for FBXL7 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL7 Gene

Orthologs for FBXL7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXL7 35
  • 93.41 (n)
  • 97.76 (a)
FBXL7 36
  • 98 (a)
(Canis familiaris)
Mammalia FBXL7 35
  • 85.7 (n)
  • 87.36 (a)
FBXL7 36
  • 87 (a)
(Mus musculus)
Mammalia Fbxl7 35
  • 89.61 (n)
  • 98.37 (a)
Fbxl7 16
Fbxl7 36
  • 98 (a)
(Pan troglodytes)
Mammalia FBXL7 35
  • 99.8 (n)
  • 100 (a)
FBXL7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fbxl7 35
  • 89.07 (n)
  • 98.57 (a)
(Monodelphis domestica)
Mammalia FBXL7 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL7 36
  • 95 (a)
(Gallus gallus)
Aves FBXL7 35
  • 85.41 (n)
  • 93.25 (a)
FBXL7 36
  • 95 (a)
(Anolis carolinensis)
Reptilia FBXL7 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl7 35
  • 78.5 (n)
  • 93.47 (a)
(Danio rerio)
Actinopterygii zgc:158346 35
  • 75.75 (n)
  • 82.79 (a)
FBXL7 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4221 37
  • 49 (a)
CG4221 35
  • 58.65 (n)
  • 50.54 (a)
CG4221 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003285 35
  • 56.94 (n)
  • 49.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 36
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
Species with no ortholog for FBXL7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL7 Gene

Gene Tree for FBXL7 (if available)
Gene Tree for FBXL7 (if available)

Paralogs for FBXL7 Gene

Paralogs for FBXL7 Gene

(2) SIMAP similar genes for FBXL7 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL7: view

Variants for FBXL7 Gene

Sequence variations from dbSNP and Humsavar for FBXL7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs723062 -- 15,558,795(-) TATGA(A/G)ACTCC intron-variant
rs12757 -- 15,628,952(-) CATGA(C/T)TGATT intron-variant
rs769265 -- 15,819,724(-) CTAAC(C/G)AAGAA intron-variant
rs769266 -- 15,819,682(-) GCACT(A/C)CATGC intron-variant
rs793424 -- 15,811,696(+) acttc(G/T)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL7 Gene

Variant ID Type Subtype PubMed ID
nsv516929 CNV Gain+Loss 19592680
esv2729824 CNV Deletion 23290073
nsv4730 CNV Insertion 18451855
nsv830214 CNV Gain 17160897
nsv4732 CNV Loss 18451855
esv2671030 CNV Deletion 23128226
nsv4733 CNV Insertion 18451855
nsv880755 CNV Gain 21882294
nsv461983 CNV Loss 19166990
essv11607 CNV CNV 17122850
esv1150 CNV CNV 17122850
essv6409 CNV CNV 17122850
dgv1759e1 CNV Complex 17122850
dgv1760e1 CNV Complex 17122850
essv19140 CNV CNV 17122850
dgv1761e1 CNV Complex 17122850
dgv1762e1 CNV Complex 17122850
essv23288 CNV CNV 17122850
nsv10671 CNV Loss 18304495
nsv442939 CNV CNV 18776908
essv11383 CNV CNV 17122850
esv2421516 CNV Deletion 20811451
dgv1763e1 CNV Complex 17122850
esv23849 CNV Loss 19812545
nsv818319 CNV Loss 17921354
esv2729825 CNV Deletion 23290073
nsv471736 CNV Loss 16327809
esv2656471 CNV Deletion 23128226
nsv823014 CNV Loss 20364138
nsv514291 CNV Loss 21397061
nsv461985 CNV Loss 19166990
nsv818320 CNV Loss 17921354
nsv4734 CNV Insertion 18451855
esv2729826 CNV Deletion 23290073
esv2395102 CNV Deletion 18987734
nsv830216 CNV Loss 17160897
esv2517640 CNV Deletion 19546169
esv2021602 CNV Deletion 18987734
esv2672541 CNV Deletion 23128226
nsv4735 CNV Loss 18451855
esv2729827 CNV Deletion 23290073

Variation tolerance for FBXL7 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXL7 Gene

Disorders for FBXL7 Gene

Relevant External Links for FBXL7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL7 Gene

Publications for FBXL7 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. (PMID: 25654763) Liu Y. … Mallampalli R.K. (Cell Death Dis 2015) 3
  4. The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. (PMID: 25778398) Liu Y. … Mallampalli R.K. (J. Biol. Chem. 2015) 3
  5. Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids. (PMID: 24486069) Park H.W. … Tantisira K.G. (J. Allergy Clin. Immunol. 2014) 3

Products for FBXL7 Gene

Sources for FBXL7 Gene