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Aliases for FBXL6 Gene

Aliases for FBXL6 Gene

  • F-Box And Leucine-Rich Repeat Protein 6 2 3 4
  • FBL6A 3 4 6
  • FBL6 3 4 6
  • F-Box/LRR-Repeat Protein 6 3
  • F-Box Protein Fbl6 3
  • F-Box Protein FBL6 4
  • PP14630 3

External Ids for FBXL6 Gene

Previous GeneCards Identifiers for FBXL6 Gene

  • GC08P143145
  • GC08U900020
  • GC08M145183
  • GC08M145583
  • GC08M145549
  • GC08M140694
  • GC08M145579

Summaries for FBXL6 Gene

Entrez Gene Summary for FBXL6 Gene

  • This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXL6 Gene

FBXL6 (F-Box And Leucine-Rich Repeat Protein 6) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXL6 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL6 Gene

Genomics for FBXL6 Gene

Regulatory Elements for FBXL6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL6 Gene

Start:
144,355,428 bp from pter
End:
144,359,376 bp from pter
Size:
3,949 bases
Orientation:
Minus strand

Genomic View for FBXL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL6 Gene

Proteins for FBXL6 Gene

  • Protein details for FBXL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N531-FBXL6_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 6
    Protein Accession:
    Q8N531
    Secondary Accessions:
    • Q53G43
    • Q9H5W9
    • Q9UKC7

    Protein attributes for FBXL6 Gene

    Size:
    539 amino acids
    Molecular mass:
    58588 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL6 Gene

Proteomics data for FBXL6 Gene at MOPED

Post-translational modifications for FBXL6 Gene

  • Ubiquitination at Lys428
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL6 Gene

Domains for FBXL6 Gene

Gene Families for FBXL6 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N531

UniProtKB/Swiss-Prot:

FBXL6_HUMAN :
  • Q8N531
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL6: view

Function for FBXL6 Gene

Molecular function for FBXL6 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL6: view

Phenotypes for FBXL6 Gene

genes like me logo Genes that share phenotypes with FBXL6: view

Animal Model Products

CRISPR Products

miRNA for FBXL6 Gene

miRTarBase miRNAs that target FBXL6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXL6 Gene

Localization for FBXL6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL6 Gene COMPARTMENTS Subcellular localization image for FBXL6 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL6 Gene

Pathways for FBXL6 Gene

SuperPathways for FBXL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination TAS 10531035
genes like me logo Genes that share ontologies with FBXL6: view

No data available for Pathways by source for FBXL6 Gene

Transcripts for FBXL6 Gene

Unigene Clusters for FBXL6 Gene

F-box and leucine-rich repeat protein 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for FBXL6 Gene

GeneLoc Exon Structure for
FBXL6
ECgene alternative splicing isoforms for
FBXL6

Expression for FBXL6 Gene

mRNA expression in normal human tissues for FBXL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL6 Gene

SOURCE GeneReport for Unigene cluster for FBXL6 Gene Hs.12271

genes like me logo Genes that share expressions with FBXL6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL6 Gene

Orthologs for FBXL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL6 35
  • 98.82 (n)
  • 98.7 (a)
FBXL6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL6 35
  • 84.64 (n)
  • 85.55 (a)
FBXL6 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL6 35
  • 85.08 (n)
  • 85.63 (a)
FBXL6 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl6 35
  • 81.08 (n)
  • 82.27 (a)
Fbxl6 16
Fbxl6 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL6 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL6 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl6 35
  • 80.33 (n)
  • 81.78 (a)
lizard
(Anolis carolinensis)
Reptilia FBXL6 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FBXL6 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006431 35
  • 48.47 (n)
  • 37.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta fbl6 35
  • 46.12 (n)
  • 36.09 (a)
fbl6 36
  • 21 (a)
OneToOne
CG13213 37
  • 33 (a)
Species with no ortholog for FBXL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL6 Gene

ENSEMBL:
Gene Tree for FBXL6 (if available)
TreeFam:
Gene Tree for FBXL6 (if available)

Paralogs for FBXL6 Gene

No data available for Paralogs for FBXL6 Gene

Variants for FBXL6 Gene

Structural Variations from Database of Genomic Variants (DGV) for FBXL6 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv8396 CNV Gain 18304495
dgv7960n71 CNV Loss 21882294
nsv891840 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
esv2664345 CNV Deletion 23128226
dgv7963n71 CNV Loss 21882294
dgv7964n71 CNV Loss 21882294
dgv7965n71 CNV Loss 21882294
dgv7966n71 CNV Loss 21882294

Relevant External Links for FBXL6 Gene

HapMap Linkage Disequilibrium report
FBXL6
Human Gene Mutation Database (HGMD)
FBXL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FBXL6 Gene

Disorders for FBXL6 Gene

No disorders were found for FBXL6 Gene.

No data available for UniProtKB/Swiss-Prot for FBXL6 Gene

Publications for FBXL6 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3

Products for FBXL6 Gene

  • Addgene plasmids for FBXL6

Sources for FBXL6 Gene

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