Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL6 Gene

protein-coding   GIFtS: 49
GCID: GC08M145579

F-Box And Leucine-Rich Repeat Protein 6

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And Leucine-Rich Repeat Protein 61 2 3
F-Box Protein FBL62 3
FBL62 3
FBL6A2 3
PP146302
F-Box/LRR-Repeat Protein 62

External Ids:    HGNC: 136031   Entrez Gene: 262332   Ensembl: ENSG000001823257   OMIM: 6090765   UniProtKB: Q8N5313   

Export aliases for FBXL6 gene to outside databases

Previous GC identifers: GC08P143145 GC08U900020 GC08M145183 GC08M145583 GC08M145549 GC08M140694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXL6 Gene:
This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein
also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF
(SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for FBXL6 Gene: 
FBXL6 (F-box and leucine-rich repeat protein 6) is a protein-coding gene. Diseases associated with FBXL6 include gastric cancer. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBXL6_HUMAN, Q8N531
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL6 gene promoter:
         AML1a   Pax-5   NRSF form 1   NRSF form 2   Max   PPAR-gamma1   STAT3   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXL6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

FBXL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145579:  view genomic region     (about GC identifiers)

Start:
145,579,091 bp from pter      End:
145,583,036 bp from pter
Size:
3,946 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315924 124,690-127,731     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXL6_HUMAN, Q8N531 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 6  
Size: 539 amino acids; 58588 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: Q53G43 Q9H5W9 Q9UKC7
Alternative splicing: 2 isoforms:  Q8N531-1   Q8N531-2   

Explore the universe of human proteins at neXtProt for FBXL6: NX_Q8N531

Explore proteomics data for FBXL6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N531

  • FBXL6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXL6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036294.2  NP_078831.4  

    ENSEMBL proteins: 
     ENSP00000403873   ENSP00000330098  

    Human Recombinant Protein Products for FBXL6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FBXL6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FBXL6
    GenScript Custom Purified and Recombinant Proteins Services for FBXL6
    Novus Biologicals FBXL6 Protein
    Novus Biologicals FBXL6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXL6 


    FBXL6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FBXL6
    OriGene Custom Antibody Services for FBXL6
    GenScript Custom Superior Antibodies Services for FBXL6
    Novus Biologicals FBXL6 Antibodies
    Abcam antibodies for FBXL6
    Cloud-Clone Corp. Antibodies for FBXL6 
    ThermoFisher Antibody for FBXL6
    LSBio Antibodies in human, mouse, rat for FBXL6 

    Assay Products for FBXL6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXL6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXL6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXL6 
    Cloud-Clone Corp. CLIAs for FBXL6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXL: F-boxes / Leucine-rich repeats

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q8N531

    ProtoNet protein and cluster: Q8N531

    1 Blocks protein domain: IPB013101 Leucine-rich repeat 2

    UniProtKB/Swiss-Prot: FBXL6_HUMAN, Q8N531
    Similarity: Contains 1 F-box domain
    Similarity: Contains 11 LRR (leucine-rich) repeats


    FBXL6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL6_HUMAN, Q8N531
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding ----
         
    FBXL6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXL6:
     Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXL6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXL6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXL6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL6
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FBXL6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXL6
    Sirion Biotech Customized adenovirus for overexpression of FBXL6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FBXL6 (see all 12)
    OriGene ORF clones in mouse, rat for FBXL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXL6 (NM_012162)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL6
    Sirion Biotech Customized lentivirus for stable overexpression of FBXL6 
                         Customized lentivirus expression plasmids for stable overexpression of FBXL6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXL6
    Search LifeMap BioReagents cell lines for FBXL6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXL6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for FBXL6 (Q8N5313 ENSP000003300984) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETV6P412123, ENSP000002664274I2D: score=2 STRING: ENSP00000266427
    TSC2P498153, ENSP000002194764I2D: score=1 STRING: ENSP00000219476
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10531035
    GO:0016567protein ubiquitination TAS10531035

    FBXL6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXL6

    Search CenterWatch for drugs/clinical trials and news about FBXL6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXL6 gene (2 alternative transcripts): 
    NM_012162.3  NM_024555.5  

    Unigene Cluster for FBXL6:

    F-box and leucine-rich repeat protein 6
    Hs.12271  [show with all ESTs]
    Unigene Representative Sequence: BC033066
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524492(uc003zbz.3) ENST00000455319 ENST00000331890 ENST00000530142(uc003zca.3 uc003zcb.3 uc010mfx.3)
    ENST00000526524 ENST00000527000 ENST00000524909 ENST00000529279 ENST00000530687

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL6
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate FBXL6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXL6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL6
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXL6 (see all 12)
    OriGene ORF clones in mouse, rat for FBXL6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXL6 (NM_012162)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL6
    Sirion Biotech Customized lentivirus for stable overexpression of FBXL6 
                         Customized lentivirus expression plasmids for stable overexpression of FBXL6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXL6
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL6

    Additional mRNA sequence: 

    AF174592.1 AK026541.1 AK223088.1 BC033066.1 

    6 DOTS entries:

    DT.100035468  DT.100812798  DT.111999  DT.95183212  DT.111998  DT.102824696 

    24/137 AceView cDNA sequences (see all 137):

    AI349081 BG698091 CB529716 AI130030 BC033066 BX284010 BM783450 BM743796 
    NM_012162 BM741819 AW083104 BF112242 BE502390 AA215393 BM784242 F10461 
    CA424813 AI819479 BU730314 BE552433 BE742632 AI521438 BM770060 AA761013 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                    -     -                       -     -                                         -                                       
    SP2:                    -     -                 -     -     -                                         -                                       
    SP3:                                                                                                  -                                       
    SP4:                                                                                                  -           -     -     -               
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for FBXL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL6 expression in normal human tissues (normalized intensities)      FBXL6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGAGCTG
    FBXL6 Expression
    About this image


    FBXL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Outflow Tract
     
     Stomach (Gastrointestinal Tract)

    See FBXL6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL6

    SOURCE GeneReport for Unigene cluster: Hs.12271
        SABiosciences Custom PCR Arrays for FBXL6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXL6
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXL6 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl61 , 5 F-box and leucine-rich repeat protein 61, 5 80.41(n)1
    81.68(a)1
      15 (36.04 cM)5
    308401  NM_013909.21  NP_038937.21 
     765357305 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL66
    Uncharacterized protein
    41(a)
    1 ↔ 1
    AAWZ02037261(5640-15727)
    zebrafish
    (Danio rerio)
    Actinopterygii FBXL66
    F-box and leucine-rich repeat protein 6
    44(a)
    1 ↔ 1
    19(22833110-22847334)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG132133
    fbl61
    CG13213-PA1 33(a)3
    44.71(n)1
    33.7(a)1
      47E33
    362011  NM_136821.21  NP_610665.21 


    ENSEMBL Gene Tree for FBXL6 (if available)
    TreeFam Gene Tree for FBXL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for FBXL6 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664345CNV Deletion23128226
    dgv7966n71CNV Loss21882294
    nsv891841CNV Loss21882294
    dgv7960n71CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294
    nsv891807CNV Loss21882294
    dgv7958n71CNV Loss21882294
    dgv7963n71CNV Loss21882294
    dgv7965n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): FBXL6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXL6
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXL6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609076    OMIM disorders: --

    2 diseases for FBXL6:    About MalaCards
    gastric cancer    


    FBXL6 for disorders           About GeneDecksing


    Export disorders for FBXL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL6 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with FBXL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T....Harper J.W. (1999)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (2009)
    9. Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. (PubMed id 18426905)1 Roukens M.G....Baker D.A. (2008)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26233 HGNC: 13603 AceView: FBXL6 Ensembl:ENSG00000182325 euGenes: HUgn26233
    ECgene: FBXL6 H-InvDB: FBXL6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXL6 gene:
    Search GeneIP for patents involving FBXL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FBXL6   OriGene RNAi products in human, mouse, rat for FBXL6  
     OriGene qPCR primer pairs and template standards for FBXL6   OriGene Protein Over-expression Lysate for FBXL6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXL6  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXL6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXL6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXL6   OriGene Custom Protein Services for FBXL6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXL6
     QIAGEN SeqTarget long-range PCR primers for resequencing FBXL6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL6
     GenScript Custom Purified and Recombinant Proteins Services for FBXL6 GenScript cDNA clones with any tag delivered in your preferred vector for FBXL6
     GenScript Custom Assay Services for FBXL6 GenScript Custom Superior Antibodies Services for FBXL6
     GenScript Custom overexpressing Cell Line Services for FBXL6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXL6 promoter
     Search Chromatin IP Primers for FBXL6
     RT2 qPCR Primer Assay in human, mouse, rat FBXL6
     GNC Network for FBXL6
     SABiosciences Custom PCR Arrays for FBXL6
     Search Tocris compounds for FBXL6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FBXL6 antibodies
     FBXL6 proteins
     FBXL6 lysates
     Antibodies for FBXL6
     See all of Abcam's Antibodies, Kits and Proteins for FBXL6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FBXL6
     Antibodies for FBXL6
     ELISAs for FBXL6
     CLIAs for FBXL6
     Search LifeMap BioReagents cell lines for FBXL6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FBXL6
     SwitchGear Promoter luciferase reporter plasmids for FBXL6
     ThermoFisher Antibody for FBXL6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXL6
    Customized:
     lentivirus for stable overexpression of FBXL6
     lentivirus expression plasmids for stable overexpression of FBXL6
     adenovirus for overexpression of FBXL6
     LSBio Antibodies in human, mouse, rat for FBXL6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXL6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4