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FBXL6 Gene

protein-coding   GIFtS: 50
GCID: GC08M145579

F-Box And Leucine-Rich Repeat Protein 6

  Search for FBXL6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 61 2 3
FBL62 3 5
FBL6A2 3 5
F-Box Protein FBL62 3
PP146302
F-Box/LRR-Repeat Protein 62

External Ids:    HGNC: 136031   Entrez Gene: 262332   Ensembl: ENSG000001823257   OMIM: 6090765   UniProtKB: Q8N5313   

Export aliases for FBXL6 gene to outside databases

Previous GC identifers: GC08P143145 GC08U900020 GC08M145183 GC08M145583 GC08M145549 GC08M140694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXL6 Gene:
This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein
also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF
(SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for FBXL6 Gene:
FBXL6 (F-box and leucine-rich repeat protein 6) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: FBXL6_HUMAN, Q8N531
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL6 gene promoter:
         AML1a   Pax-5   NRSF form 1   NRSF form 2   Max   PPAR-gamma1   STAT3   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXL6 promoter sequence
   Search Chromatin IP Primers for FBXL6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

FBXL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145579:  view genomic region     (about GC identifiers)

Start:
145,579,091 bp from pter      End:
145,583,036 bp from pter
Size:
3,946 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315924 124,690-127,731     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBXL6_HUMAN, Q8N531 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 6  
Size: 539 amino acids; 58588 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: Q53G43 Q9H5W9 Q9UKC7
Alternative splicing: 2 isoforms:  Q8N531-1   Q8N531-2   

Explore the universe of human proteins at neXtProt for FBXL6: NX_Q8N531

Explore proteomics data for FBXL6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys428
  • Modification sites at PhosphoSitePlus

  • See FBXL6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_036294.2  NP_078831.4  

    ENSEMBL proteins: 
     ENSP00000403873   ENSP00000330098  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXL: F-boxes / Leucine-rich repeats

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q8N531

    ProtoNet protein and cluster: Q8N531

    1 Blocks protein domain: IPB013101 Leucine-rich repeat 2

    UniProtKB/Swiss-Prot: FBXL6_HUMAN, Q8N531
    Similarity: Contains 1 F-box domain
    Similarity: Contains 11 LRR (leucine-rich) repeats


    Find genes that share domains with FBXL6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL6_HUMAN, Q8N531
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS10531035
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXL6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FBXL6:
     Decreased POU5F1-GFP protein e  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXL6
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    miRNA
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    hsa-mir-26b-5p (MIRT029613)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FBXL6
    Interactions:

        GeneGlobe Interaction Network for FBXL6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for FBXL6 (Q8N5313 ENSP000003300984) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETV6P412123, ENSP000002664274I2D: score=2 STRING: ENSP00000266427
    TSC2P498153, ENSP000002194764I2D: score=1 STRING: ENSP00000219476
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    UBCENSP000003448184STRING: ENSP00000344818
    XPCENSP000002850214STRING: ENSP00000285021
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10531035
    GO:0016567protein ubiquitination TAS10531035

    Find genes that share ontologies with FBXL6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXL6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXL6 gene (2 alternative transcripts): 
    NM_012162.3  NM_024555.5  

    Unigene Cluster for FBXL6:

    F-box and leucine-rich repeat protein 6
    Hs.12271  [show with all ESTs]
    Unigene Representative Sequence: BC033066
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524492(uc003zbz.3) ENST00000455319 ENST00000331890 ENST00000530142(uc003zca.3 uc003zcb.3 uc010mfx.3)
    ENST00000526524 ENST00000527000 ENST00000524909 ENST00000529279 ENST00000530687

    miRNA
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    Additional mRNA sequence: 

    AF174592.1 AK026541.1 AK223088.1 BC033066.1 

    6 DOTS entries:

    DT.100035468  DT.100812798  DT.111999  DT.95183212  DT.111998  DT.102824696 

    Selected AceView cDNA sequences (see all 137):

    BM770050 BM783669 BM783425 BM784242 BM852717 AL713783 AI819479 BF112242 
    BM770060 AA761013 AA215393 BM555776 AI349081 CA424813 AI990159 BE742632 
    BE552433 BX284010 BC033066 BM723694 BQ006792 BM771267 F10461 AI130030 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXL6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                    -     -                       -     -                                         -                                       
    SP2:                    -     -                 -     -     -                                         -                                       
    SP3:                                                                                                  -                                       
    SP4:                                                                                                  -           -     -     -               
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for FBXL6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXL6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGAGCTG
    FBXL6 Expression
    About this image


    FBXL6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)
             Outflow Tract
     
     Stomach (Gastrointestinal Tract)
    FBXL6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXL6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12271
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXL6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl61 , 5 F-box and leucine-rich repeat protein 61, 5 81.08(n)1
    82.27(a)1
      15 (36.04 cM)5
    308401  NM_013909.21  NP_038937.21 
     765357305 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL66
    F-box and leucine-rich repeat protein 6
    42(a)
    1 ↔ 1
    AAWZ02037261(5640-15727)
    zebrafish
    (Danio rerio)
    Actinopterygii FBXL66
    F-box and leucine-rich repeat protein 6
    44(a)
    1 ↔ 1
    19(22833110-22847334) ENSDARG00000077227
    fruit fly
    (Drosophila melanogaster)
    Insecta CG132133
    fbl61
    fbl61 33(a)3
    46.12(n)1
    36.09(a)1
      47E33
    362011  NM_136821.21  NP_610665.21 


    ENSEMBL Gene Tree for FBXL6 (if available)
    TreeFam Gene Tree for FBXL6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FBXL6 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664345CNV Deletion23128226
    dgv7966n71CNV Loss21882294
    nsv891841CNV Loss21882294
    dgv7960n71CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294
    nsv891807CNV Loss21882294
    dgv7958n71CNV Loss21882294
    dgv7963n71CNV Loss21882294
    dgv7965n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FBXL6
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609076    OMIM disorders: --


    Find genes that share disorders with FBXL6           About GenesLikeMe


    Export disorders for FBXL6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXL6 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with FBXL6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (J. Proteome Res. 2009)
    9. Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination. (PubMed id 18426905)1 Roukens M.G....Baker D.A. (Mol. Cell. Biol. 2008)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26233 HGNC: 13603 AceView: FBXL6 Ensembl:ENSG00000182325 euGenes: HUgn26233
    ECgene: FBXL6 H-InvDB: FBXL6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXL6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXL6 gene:
    Search GeneIP for patents involving FBXL6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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