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Aliases for FBXL6 Gene

Aliases for FBXL6 Gene

  • F-Box And Leucine Rich Repeat Protein 6 2 3 5
  • FBL6A 3 4
  • FBL6 3 4
  • F-Box And Leucine-Rich Repeat Protein 6 4
  • F-Box/LRR-Repeat Protein 6 3
  • F-Box Protein Fbl6 3
  • F-Box Protein FBL6 4
  • PP14630 3

External Ids for FBXL6 Gene

Previous GeneCards Identifiers for FBXL6 Gene

  • GC08P143145
  • GC08U900020
  • GC08M145183
  • GC08M145583
  • GC08M145549
  • GC08M140694
  • GC08M145579

Summaries for FBXL6 Gene

Entrez Gene Summary for FBXL6 Gene

  • This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for FBXL6 Gene

FBXL6 (F-Box And Leucine Rich Repeat Protein 6) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000271698.

UniProtKB/Swiss-Prot for FBXL6 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL6 Gene

Genomics for FBXL6 Gene

Regulatory Elements for FBXL6 Gene

Enhancers for FBXL6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G143595 1.1 ENCODE 9.9 +761.4 761445 5.1 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B NAPRT JRK LOC105375803 ZNF696 ZNF623 LRRC14 GSDMD TIGD5 ADCK5 VPS28
GH08G144353 1.3 Ensembl ENCODE 0.7 +2.9 2864 6.7 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13 CPSF1 VPS28 TONSL FBXL6 TMEM249 ENSG00000271698
GH08G144363 0.8 ENCODE 0.7 -3.7 -3700 0.2 ELF3 DRAP1 MXI1 SAP130 ARID4B CEBPG HBP1 ZNF48 RARA TEAD3 CPSF1 VPS28 TONSL-AS1 TONSL HSF1 BOP1 FBXL6 LOC101928902
GH08G144369 0.9 ENCODE 0.4 -10.1 -10135 0.7 HDAC1 TBP HDGF PKNOX1 ATF1 RB1 CREB3L1 KLF17 FEZF1 NFXL1 VPS28 TONSL-AS1 TONSL HSF1 BOP1 LOC101928902 FBXL6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL6 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FBXL6 Gene

144,355,428 bp from pter
144,359,376 bp from pter
3,949 bases
Minus strand

Genomic View for FBXL6 Gene

Genes around FBXL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL6 Gene

Proteins for FBXL6 Gene

  • Protein details for FBXL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 6
    Protein Accession:
    Secondary Accessions:
    • Q53G43
    • Q9H5W9
    • Q9UKC7

    Protein attributes for FBXL6 Gene

    539 amino acids
    Molecular mass:
    58588 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL6 Gene


neXtProt entry for FBXL6 Gene

Post-translational modifications for FBXL6 Gene

  • Ubiquitination at Lys428
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL6 Gene

Domains & Families for FBXL6 Gene

Gene Families for FBXL6 Gene

Protein Domains for FBXL6 Gene

Suggested Antigen Peptide Sequences for FBXL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL6: view

No data available for UniProtKB/Swiss-Prot for FBXL6 Gene

Function for FBXL6 Gene

Molecular function for FBXL6 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 10531035
genes like me logo Genes that share ontologies with FBXL6: view
genes like me logo Genes that share phenotypes with FBXL6: view

Animal Model Products

CRISPR Products

miRNA for FBXL6 Gene

miRTarBase miRNAs that target FBXL6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FBXL6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL6 Gene

Localization for FBXL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL6 gene
Compartment Confidence
nucleus 3
mitochondrion 2
plasma membrane 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL6 Gene

Pathways & Interactions for FBXL6 Gene

SuperPathways for FBXL6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 10531035
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXL6: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL6 Gene

Drugs & Compounds for FBXL6 Gene

No Compound Related Data Available

Transcripts for FBXL6 Gene

Unigene Clusters for FBXL6 Gene

F-box and leucine-rich repeat protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FBXL6

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP7: - -

Relevant External Links for FBXL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL6 Gene

This gene is overexpressed in Nasal epithelium (51.8), Lung (9.2), and Plasma (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL6 Gene:


SOURCE GeneReport for Unigene cluster for FBXL6 Gene:


Evidence on tissue expression from TISSUES for FBXL6 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with FBXL6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL6 Gene

Orthologs for FBXL6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL6 34 35
  • 98.82 (n)
(Canis familiaris)
Mammalia FBXL6 34 35
  • 85.08 (n)
(Bos Taurus)
Mammalia FBXL6 34 35
  • 84.64 (n)
(Mus musculus)
Mammalia Fbxl6 34 16 35
  • 81.08 (n)
(Rattus norvegicus)
Mammalia Fbxl6 34
  • 80.33 (n)
(Monodelphis domestica)
Mammalia FBXL6 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL6 35
  • 46 (a)
(Anolis carolinensis)
Reptilia FBXL6 35
  • 42 (a)
(Danio rerio)
Actinopterygii FBXL6 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006431 34
  • 48.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta fbl6 34 35
  • 46.12 (n)
CG13213 36
  • 33 (a)
Species where no ortholog for FBXL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL6 Gene

Gene Tree for FBXL6 (if available)
Gene Tree for FBXL6 (if available)

Paralogs for FBXL6 Gene

Paralogs for FBXL6 Gene

genes like me logo Genes that share paralogs with FBXL6: view

Variants for FBXL6 Gene

Sequence variations from dbSNP and Humsavar for FBXL6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs374071862 Pathogenic 144,359,875(+) TGCCT(C/T)GAATG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs375088539 Pathogenic 144,360,300(+) CCTAT(C/T)AGCTT nc-transcript-variant, upstream-variant-2KB, reference, stop-gained
rs397514538 Pathogenic 144,359,860(+) GGCAC(C/T)GGCAT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs397514657 Pathogenic 144,359,647(+) CGTCT(C/G/T)TGTGC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs398123067 Pathogenic 144,360,343(+) GTTGG(A/C)CGCCA nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FBXL6 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv2664345 CNV deletion 23128226
esv2759652 CNV gain+loss 17122850
esv3310508 CNV novel sequence insertion 20981092
esv3382509 CNV insertion 20981092
esv3399198 CNV insertion 20981092
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612931 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for FBXL6 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL6 Gene

Disorders for FBXL6 Gene

Relevant External Links for FBXL6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL6 Gene

Publications for FBXL6 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for FBXL6 Gene

  • Addgene plasmids for FBXL6

Sources for FBXL6 Gene

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