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Aliases for FBXL5 Gene

Aliases for FBXL5 Gene

  • F-Box And Leucine-Rich Repeat Protein 5 2 3 4
  • FBL5 3 4 6
  • F-Box Protein FBL4/FBL5 3 4
  • P45SKP2-Like Protein 3 4
  • FBL4 3 4
  • FLR1 3 4
  • F-Box/LRR-Repeat Protein 5 3
  • F-Box Protein FBL5 3

External Ids for FBXL5 Gene

Summaries for FBXL5 Gene

Entrez Gene Summary for FBXL5 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]

GeneCards Summary for FBXL5 Gene

FBXL5 (F-Box And Leucine-Rich Repeat Protein 5) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Protein folding. GO annotations related to this gene include ubiquitin-protein transferase activity and iron ion binding.

UniProtKB/Swiss-Prot for FBXL5 Gene

  • Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Gene Wiki entry for FBXL5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL5 Gene

Genomics for FBXL5 Gene

Genomic Location for FBXL5 Gene

Start:
15,604,384 bp from pter
End:
15,681,679 bp from pter
Size:
77,296 bases
Orientation:
Minus strand

Genomic View for FBXL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL5 Gene

Regulatory Elements for FBXL5 Gene

Proteins for FBXL5 Gene

  • Protein details for FBXL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKA1-FBXL5_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 5
    Protein Accession:
    Q9UKA1
    Secondary Accessions:
    • A8MSK4
    • B4DIB5
    • Q4W5A8
    • Q8NHP3
    • Q9NXN2
    • Q9P0I0
    • Q9P0X5
    • Q9UJT7
    • Q9UKC8

    Protein attributes for FBXL5 Gene

    Size:
    691 amino acids
    Molecular mass:
    78555 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1/IRP1, IREB2/IRP2; the interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued.
    SequenceCaution:
    • Sequence=AAF66616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF67489.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH30656.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW92737.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBXL5 Gene

    Alternative splice isoforms for FBXL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL5 Gene

Proteomics data for FBXL5 Gene at MOPED

Post-translational modifications for FBXL5 Gene

  • Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL5 Gene

Domains for FBXL5 Gene

Gene Families for FBXL5 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

UniProtKB/Swiss-Prot:

FBXL5_HUMAN
Domain:
  • The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded.:
    • Q9UKA1
  • Contains 1 F-box domain.:
    • Q9UKA1
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.:
    • Q9UKA1
genes like me logo Genes that share domains with FBXL5: view

Function for FBXL5 Gene

Molecular function for FBXL5 Gene

UniProtKB/Swiss-Prot Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Gene Ontology (GO) - Molecular Function for FBXL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005506 iron ion binding IDA 19762596
GO:0005515 protein binding IPI 17532294
genes like me logo Genes that share ontologies with FBXL5: view
genes like me logo Genes that share phenotypes with FBXL5: view

Animal Models for FBXL5 Gene

MGI Knock Outs for FBXL5:

miRNA for FBXL5 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FBXL5 Gene

Localization for FBXL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL5 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL5 Gene COMPARTMENTS Subcellular localization image for FBXL5 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for FBXL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0019005 SCF ubiquitin ligase complex IDA 19762596
GO:0048471 perinuclear region of cytoplasm IDA 17532294
genes like me logo Genes that share ontologies with FBXL5: view

Pathways for FBXL5 Gene

genes like me logo Genes that share pathways with FBXL5: view

UniProtKB/Swiss-Prot Q9UKA1-FBXL5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 17532294
GO:0055072 iron ion homeostasis IMP 19762596
GO:1903364 positive regulation of cellular protein catabolic process IEA --
genes like me logo Genes that share ontologies with FBXL5: view

Transcripts for FBXL5 Gene

Unigene Clusters for FBXL5 Gene

F-box and leucine-rich repeat protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7:

Relevant External Links for FBXL5 Gene

GeneLoc Exon Structure for
FBXL5
ECgene alternative splicing isoforms for
FBXL5

Expression for FBXL5 Gene

mRNA expression in normal human tissues for FBXL5 Gene

mRNA differential expression in normal tissues according to GTEx for FBXL5 Gene

This gene is overexpressed in Whole Blood (7.6).

SOURCE GeneReport for Unigene cluster for FBXL5 Gene Hs.643433

genes like me logo Genes that share expressions with FBXL5: view

Orthologs for FBXL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL5 36
  • 99.57 (n)
  • 99.71 (a)
FBXL5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL5 36
  • 92.91 (n)
  • 94.5 (a)
FBXL5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL5 36
  • 94.69 (n)
  • 96.24 (a)
FBXL5 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl5 36
  • 90.63 (n)
  • 93.77 (a)
Fbxl5 16
Fbxl5 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL5 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL5 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl5 36
  • 90.11 (n)
  • 93.72 (a)
chicken
(Gallus gallus)
Aves FBXL5 36
  • 80.76 (n)
  • 81.05 (a)
FBXL5 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL5 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fbxl5-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl5 36
  • 69.14 (n)
  • 69.24 (a)
Str.19634 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7300 36
zebrafish
(Danio rerio)
Actinopterygii fbxl5 36
  • 59.85 (n)
  • 58.95 (a)
fbxl5 37
  • 57 (a)
OneToOne
wufb52d06 36
Species with no ortholog for FBXL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL5 Gene

ENSEMBL:
Gene Tree for FBXL5 (if available)
TreeFam:
Gene Tree for FBXL5 (if available)

Paralogs for FBXL5 Gene

Pseudogenes.org Pseudogenes for FBXL5 Gene

genes like me logo Genes that share paralogs with FBXL5: view

No data available for Paralogs for FBXL5 Gene

Variants for FBXL5 Gene

Sequence variations from dbSNP and Humsavar for FBXL5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs10214 -- 15,604,808(+) AGATA(C/T)ACTTA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs10303 -- 15,604,637(+) GCAAA(A/G)TGCAA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs872678 -- 15,654,075(+) TTAAA(C/T)TGCTG intron-variant
rs952281 -- 15,629,853(-) CTTAA(A/C)GTAAT intron-variant
rs1127154 -- 15,655,274(-) CTTTC(C/G/T)TGAAG reference, missense, nc-transcript-variant, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL5 Gene

Variant ID Type Subtype PubMed ID
dgv1586e1 CNV Complex 17122850
dgv1587e1 CNV Complex 17122850
nsv428439 CNV Gain+Loss 18775914
esv26392 CNV Gain 19812545
dgv315n21 CNV Loss 19592680
esv1293360 CNV Insertion 17803354
esv27769 CNV Gain 19812545
nsv292453 CNV Loss 16902084

Relevant External Links for FBXL5 Gene

HapMap Linkage Disequilibrium report
FBXL5

Disorders for FBXL5 Gene

No disorders were found for FBXL5 Gene.

No data available for UniProtKB/Swiss-Prot for FBXL5 Gene

Publications for FBXL5 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. FBXL5 interacts with p150Glued and regulates its ubiquitination. (PMID: 17532294) Zhang N. … Yao X. (Biochem. Biophys. Res. Commun. 2007) 3 4 23
  3. Control of iron homeostasis by an iron-regulated ubiquitin ligase. (PMID: 19762596) Vashisht A.A. … Wohlschlegel J.A. (Science 2009) 3 4
  4. An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. (PMID: 19762597) Salahudeen A.A. … Bruick R.K. (Science 2009) 3 4
  5. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 3 4

Products for FBXL5 Gene

Sources for FBXL5 Gene

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