Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL5 Gene

protein-coding   GIFtS: 54
GCID: GC04M015548

F-box and leucine-rich repeat protein 5
  Search for FBXL5
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FBXL5    

Aliases
for FBXL5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
F-Box And Leucine-Rich Repeat Protein 51 2 3     F-Box Protein FBL4/FBL52 3
FBL51 2 3 5     P45SKP2-Like Protein2 3
FBL41 2 3     F-Box Protein FBL52
FLR11 2 3     F-Box/LRR-Repeat Protein 52

External Ids:    HGNC: 136021   Entrez Gene: 262342   Ensembl: ENSG000001185647   OMIM: 6056555   UniProtKB: Q9UKA13   
ORGUL members:         
NONCODE:n410027    

Export aliases for FBXL5 gene to outside databases

Previous GC identifers: GC04M015421 GC04M015294 GC04M015357 GC04M015282 GC04M014956


Summaries
for FBXL5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FBXL5:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,
the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3
classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different
protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls
class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript
variants have been described for this locus. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron
homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level,
it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome.
Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued

Gene Wiki entry for FBXL5


Genomic Views
for FBXL5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL5 gene promoter:
         AhR   SREBP-1c   AP-4   LUN-1   SREBP-1b   CREB   SREBP-1a   deltaCREB   ATF6   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBXL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.32   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.33

FBXL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M015548:  view genomic region     (about GC identifiers)

Start:
 15,606,007 bp from pter      End:
 15,683,302 bp from pter
Size:
 77,296 bases      Orientation:
 minus strand

Proteins
for FBXL5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 5  
Size: 691 amino acids; 78555 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1/IRP1, IREB2/IRP2; the
interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued
Subcellular location: Cytoplasm, perinuclear region
Sequence caution: Sequence=AAF66616.1; Type=Erroneous initiation; Sequence=AAF67489.1; Type=Erroneous initiation;
Sequence=AAH30656.1; Type=Erroneous initiation; Sequence=EAW92737.1; Type=Erroneous gene model prediction;
5 PDB 3D structures from and Proteopedia for FBXL5:
3U9J (3D)        3U9M (3D)        3V5X (3D)        3V5Y (3D)        3V5Z (3D)    
Secondary accessions: A8MSK4 B4DIB5 Q4W5A8 Q8NHP3 Q9NXN2 Q9P0I0 Q9P0X5 Q9UJT7 Q9UKC8
Alternative splicing: 2 isoforms:  Q9UKA1-1   Q9UKA1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXL5: NX_Q9UKA1

Post-translational modifications:

  • Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is
    • regulated by the hemerythrin-like region that acts as an oxygen and iron sensor1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UKA1

    • FBXL5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180463.1  NP_001180464.1  NP_036293.1  

    ENSEMBL proteins: 
     ENSP00000344866   ENSP00000425472   ENSP00000425027   ENSP00000408679   ENSP00000426993  
     ENSP00000425541   ENSP00000421070   ENSP00000423961   ENSP00000422049   ENSP00000424423  
     ENSP00000371795  
    Reactome Protein details: Q9UKA1
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): FBXL5
    OriGene Custom Protein Services for FBXL5 
    GenScript Custom Purified and Recombinant Proteins Services for FBXL5
    Novus Biologicals FBXL5 Proteins
    Novus Biologicals FBXL5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBXL5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0019005SCF ubiquitin ligase complex IDA19762597
    GO:0048471perinuclear region of cytoplasm IDA17532294


    FBXL5 for ontologies           About GeneDecksing



    FBXL5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXL5 
    GenScript Custom Superior Antibodies Services for FBXL5
    Novus Biologicals FBXL5 Antibodies
    Search for Antibodies for FBXL5 at Abcam  
    Uscn Antibodies for FBXL5
    ThermoFisher Antibody for FBXL5

    Assay Products for FBXL5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXL5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FBXL5

    Protein Domains /
    Families
    for FBXL5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FBXL5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom_cyclin-like
     IPR012312 Haemerythrin/HHE_cat-bd_motif

    Graphical View of Domain Structure for InterPro Entry Q9UKA1

    ProtoNet protein and cluster: Q9UKA1

    3 Blocks protein families:
    IPB001611 Leucine-rich repeat signature
    IPB002063 Hemerythrin
    IPB013101 Leucine-rich repeat 2


    UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
    Domain: The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center.
    In absence of oxygen and iron, the protein is ubiquitinated and degraded
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 LRR (leucine-rich) repeats


    Function
    for FBXL5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
    Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron
    homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level,
    it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome.
    Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): FBXL5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL5
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXL5 (see all 29):
    hsa-miR-596 hsa-miR-100* hsa-miR-607 hsa-miR-106a hsa-miR-411 hsa-miR-374a hsa-miR-519a hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: FBXL5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXL5 (see all 7)
    OriGene shRNA RFP: FBXL5
    OriGene siRNA: FBXL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FBXL5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL5 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FBXL5 (NM_012161)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for FBXL5
    Search LifeMap BioReagents cell lines for FBXL5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL5

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005506iron ion binding IDA19762596
    GO:0005515protein binding IPI19762597


    FBXL5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FBXL5:
     Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-out Fbxl5tm1Kei for FBXL5
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Fbxl5):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  nervous system 

    FBXL5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FBXL5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chaperonin-mediated protein folding
    		Chaperonin-mediated protein folding1.00
    		Association of TriC/CCT with target proteins during biosynthesis0.60
    		Protein folding0.91
    2Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for FBXL5
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Metabolism of proteins
    Protein folding


    UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
    Pathway: Protein modification; protein ubiquitination


    FBXL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for FBXL5 (Q9UKA12, 3 ENSP000003448664) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253275 I2D: score=2 
    PLK1P533502, 3MINT-8266876 I2D: score=2 
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    DCTN1Q142033, ENSP000003547914I2D: score=1 STRING: ENSP00000354791
    IREB2P482003, ENSP000002588864I2D: score=1 STRING: ENSP00000258886
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA19762596
    GO:0055072iron ion homeostasis IMP19762596


    FBXL5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FBXL5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXL5
    Search CenterWatch for drugs/clinical trials and news about FBXL5 

    Transcripts
    for FBXL5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FBXL5 gene (3 alternative transcripts): 
    NM_001193534.1  NM_001193535.1  NM_012161.3  

    Unigene Cluster for FBXL5:

    F-box and leucine-rich repeat protein 5
    Hs.643433  [show with all ESTs]
    Unigene Representative Sequence: NR_036464
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341285(uc010idw.2 uc003gob.2 uc010idx.2 uc003goc.2 uc003god.2)
    ENST00000513163 ENST00000511441 ENST00000412094 ENST00000507700(uc010idy.2)
    ENST00000504837 ENST00000512066 ENST00000503196 ENST00000509314 ENST00000510802
    ENST00000507899 ENST00000515679 ENST00000514541 ENST00000382358

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): FBXL5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL5
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXL5 (see all 29):
    hsa-miR-596 hsa-miR-100* hsa-miR-607 hsa-miR-106a hsa-miR-411 hsa-miR-374a hsa-miR-519a hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: FBXL5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXL5 (see all 7)
    OriGene shRNA RFP: FBXL5
    OriGene siRNA: FBXL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL5 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FBXL5 (NM_012161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL5

    Additional cDNA sequence: 

    AF052097.1 AF142481.1 AF157323.1 AF174591.1 AF176700.1 AF199420.1 AK000153.1 AK295510.1 
    AK310860.1 AL832808.1 BC012320.1 BC030656.1 BX537957.1 NR_036464.1 

    19 DOTS entries:

    DT.100826053  DT.100028481  DT.100826052  DT.448969  DT.100826049  DT.121249054  DT.100826051  DT.121249018 
    DT.121248934  DT.102826125  DT.121249067  DT.97764093  DT.100711691  DT.100826048  DT.121248782  DT.121249069 
    DT.121249081  DT.100736518  DT.99990673 

    24/292 AceView cDNA sequences (see all 292):

    Z42646 AA345228 AL602558 BU509125 AA346370 CA311065 AA279507 AL708728 
    AW051434 AW269885 AL708595 T51964 AI986378 AV724059 AF199420 BU618644 
    CD107477 CF995117 CA389802 AA707841 BQ008436 AA814461 AA279508 AF157323 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                  -                             -                                             
    SP2:                                                  -     -                       -                                             
    SP3:                                -                 -     -                       -                                             
    SP4:                                                  -     -                       -                                             
    SP5:                                                  -     -     -                 -                                             


    ECgene alternative splicing isoforms for FBXL5

    Expression
    for FBXL5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGAAGACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FBXL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL5

    SOURCE GeneReport for Unigene cluster: Hs.643433
        SABiosciences Expression via Pathway-Focused PCR Array including FBXL5: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL5

    Orthologs
    for FBXL5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FBXL5 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fbxl51 , 5 F-box and leucine-rich repeat protein 51, 5 90.61(n)1
    93.76(a)1    		   5 (23.81 cM)5
    2429601  NM_001159963.11  NP_001153435.11 
     437446165 
    chicken
    (Gallus gallus)    		 Aves FBXL51 F-box and leucine-rich repeat protein 5 80.68(n)
    81.17(a)    		   422829  XM_420776.3  XP_420776.3 
    lizard
    (Anolis carolinensis)    		 Reptilia FBXL56
    		 --
    		 77(a)
    		 1 ↔ 1
    		 4(124067729-124095845)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fbxl5-prov2 F-box and leucine-rich repeat protein 5 78.98(n)    BC052101.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb52d062 Danio rerio cDNA clone IMAGE6792653, partial cds 76(n)    BC054590.1 


    ENSEMBL Gene Tree for FBXL5 (if available)
    TreeFam Gene Tree for FBXL5 (if available) 

    Paralogs
    for FBXL5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXL5 gene

    FBXL5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FBXL5
    PGOHUM00000246089


    Genomic Variants
    for FBXL5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for FBXL5
         4 CNVs: 3482 6242 63760 91950
         1 Indel: 63761
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL5
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXL5

    Disorders / Diseases
    for FBXL5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FBXL5 for disorders           About MalaCards

    FBXL5 for disorders           About GeneDecksing

    OMIM gene information: 605655    OMIM disorders: --


    Export disorders for FBXL5 gene to outside databases

    Publications
    for FBXL5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL5 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with FBXL5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. FBXL5 interacts with p150Glued and regulates its ubiquitination. (PubMed id 17532294)1, 2, 9 Zhang N.... Yao X. (2007)
    3. Structural and molecular characterization of iron-sens ing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL 5). (PubMed id 22253436)1, 2 Thompson J.W....Bruick R.K. (2012)
    4. Control of iron homeostasis by an iron-regulated ubiquitin ligase. (PubMed id 19762596)1, 2 Vashisht A.A.... Wohlschlegel J.A. (2009)
    5. An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. (PubMed id 19762597)1, 2 Salahudeen A.A.... Bruick R.K. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
    9. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
    10. The structural basis of iron sensing by the human F-box protein FBXL5. (PubMed id 22492618)2 Shu C.... Li P. (2012)

    External Searches for FBXL5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FBXL5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26234 HGNC: 13602 AceView: FBXL5 Ensembl:ENSG00000118564 euGenes: HUgn26234
    ECgene: FBXL5 H-InvDB: FBXL5

    Other Databases showing FBXL5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FBXL5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FBXL5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FBXL5 gene:
    Search GeneIP for patents involving FBXL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for FBXL5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for FBXL5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXL5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL5  
     OriGene Protein Over-expression Lysate for FBXL5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FBXL5   OriGene 3'-UTR Clone for FBXL5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXL5   OriGene Custom Protein Services for FBXL5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXL5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL5
     GenScript Custom Purified and Recombinant Proteins Services for FBXL5 GenScript cDNA clones with any tag delivered in your preferred vector for FBXL5
     GenScript Custom Assay Services for FBXL5 GenScript Custom Superior Antibodies Services for FBXL5
     GenScript Custom overexpressing Cell Line Services for FBXL5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXL5 promoter
     Search Chromatin IP Primers for FBXL5
     RT2 qPCR Primer Assay in human, mouse, rat FBXL5
     GNC Network for FBXL5
     SABiosciences PCR Arrays including human, mouse, rat FBXL5
     Search Tocris compounds for FBXL5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FBXL5 antibodies
     FBXL5 proteins
     FBXL5 lysates
     Search for Antibodies for FBXL5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FBXL5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FBXL5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FBXL5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL5
     SwitchGear 3'UTR luciferase reporter plasmids for FBXL5
     SwitchGear Promoter luciferase reporter plasmids for FBXL5
     ThermoFisher Antibody for FBXL5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      FBXL5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4