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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL5 Gene

protein-coding   GIFtS: 54
GCID: GC04M015548

F-Box And Leucine-Rich Repeat Protein 5

  Search for FBXL5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
F-Box And Leucine-Rich Repeat Protein 51 2 3     F-Box Protein FBL4/FBL52 3
FBL52 3 5     P45SKP2-Like Protein2 3
FBL42 3     F-Box Protein FBL52
FLR12 3     F-Box/LRR-Repeat Protein 52

External Ids:    HGNC: 136021   Entrez Gene: 262342   Ensembl: ENSG000001185647   OMIM: 6056555   UniProtKB: Q9UKA13   
ORGUL members:         
NONCODE14:n410027      

Export aliases for FBXL5 gene to outside databases

Previous GC identifers: GC04M015421 GC04M015294 GC04M015357 GC04M015282 GC04M014956


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXL5 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.
Alternatively spliced transcript variants have been described for this locus. (provided by RefSeq, Aug 2010)

GeneCards Summary for FBXL5 Gene: 
FBXL5 (F-box and leucine-rich repeat protein 5) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Chaperonin-mediated protein folding and Post-translational protein modification. GO annotations related to this gene include ubiquitin-protein ligase activity and iron ion binding.

UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron
homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen
level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the
proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued

Gene Wiki entry for FBXL5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006316.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL5 gene promoter:
         AhR   SREBP-1c   AP-4   LUN-1   SREBP-1b   CREB   SREBP-1a   deltaCREB   ATF6   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.32   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.33

FBXL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M015548:  view genomic region     (about GC identifiers)

Start:
15,606,007 bp from pter      End:
15,683,302 bp from pter
Size:
77,296 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 5  
Size: 691 amino acids; 78555 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with ACO1/IRP1, IREB2/IRP2; the
interaction depends on the 4Fe-4S cluster. Interacts with DCTN1/p150-glued
Subcellular location: Cytoplasm, perinuclear region
Sequence caution: Sequence=AAF66616.1; Type=Erroneous initiation; Sequence=AAF67489.1; Type=Erroneous initiation;
Sequence=AAH30656.1; Type=Erroneous initiation; Sequence=EAW92737.1; Type=Erroneous gene model prediction;
5 PDB 3D structures from and Proteopedia for FBXL5:
3U9J (3D)        3U9M (3D)        3V5X (3D)        3V5Y (3D)        3V5Z (3D)    
Secondary accessions: A8MSK4 B4DIB5 Q4W5A8 Q8NHP3 Q9NXN2 Q9P0I0 Q9P0X5 Q9UJT7 Q9UKC8
Alternative splicing: 2 isoforms:  Q9UKA1-1   Q9UKA1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXL5: NX_Q9UKA1

Explore proteomics data for FBXL5 at MOPED 

Post-translational modifications:

  • UniProtKB: Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is
    regulated by the hemerythrin-like region that acts as an oxygen and iron sensor
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKA1

  • FBXL5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXL5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180463.1  NP_001180464.1  NP_036293.1  

    ENSEMBL proteins: 
     ENSP00000344866   ENSP00000425472   ENSP00000425027   ENSP00000408679   ENSP00000426993  
     ENSP00000425541   ENSP00000421070   ENSP00000423961   ENSP00000422049   ENSP00000424423  
     ENSP00000371795  
    Reactome Protein details: Q9UKA1
    Human Recombinant Protein Products for FBXL5: 
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    Cloud-Clone Corp. Proteins for FBXL5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0019005SCF ubiquitin ligase complex IDA19762596
    GO:0048471perinuclear region of cytoplasm IDA17532294

    FBXL5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXL: F-boxes / Leucine-rich repeats

    3 InterPro protein domains:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom_cyclin-like
     IPR012312 Haemerythrin/HHE_cat-bd_motif

    Graphical View of Domain Structure for InterPro Entry Q9UKA1

    ProtoNet protein and cluster: Q9UKA1

    3 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB002063 Hemerythrin
    IPB013101 Leucine-rich repeat 2


    UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
    Domain: The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron
    metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 LRR (leucine-rich) repeats


    FBXL5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL5_HUMAN, Q9UKA1
    Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron
    homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen
    level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the
    proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005506iron ion binding IDA19762596
    GO:0005515protein binding IPI17532294
         
    FBXL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FBXL5:
     Increased cell death HMECs cel 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Fbxl5):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system 

    FBXL5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fbxl5tm1Kei for FBXL5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXL5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for FBXL5
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Metabolism of proteins
    Protein folding


    UniProtKB/Swiss-Prot: FBXL5_HUMAN, Q9UKA1
    Pathway: Protein modification; protein ubiquitination


    FBXL5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXL5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for FBXL5 (Q9UKA12, 3 ENSP000003448664) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253275 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253275 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253275 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253275 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253275 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA17532294
    GO:0055072iron ion homeostasis IMP19762596

    FBXL5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about FBXL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for FBXL5 gene (3 alternative transcripts): 
    NM_001193534.1  NM_001193535.1  NM_012161.3  

    Unigene Cluster for FBXL5:

    F-box and leucine-rich repeat protein 5
    Hs.643433  [show with all ESTs]
    Unigene Representative Sequence: NR_036464
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341285(uc010idw.2 uc003gob.2 uc010idx.2 uc003goc.2 uc003god.2)
    ENST00000513163 ENST00000511441 ENST00000412094 ENST00000507700(uc010idy.2)
    ENST00000504837 ENST00000512066 ENST00000503196 ENST00000509314 ENST00000510802
    ENST00000507899 ENST00000515679 ENST00000514541 ENST00000382358
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    Additional mRNA sequence: 

    AF052097.1 AF142481.1 AF157323.1 AF174591.1 AF176700.1 AF199420.1 AK000153.1 AK295510.1 
    AK310860.1 AL832808.1 BC012320.1 BC030656.1 BX537957.1 NR_036464.1 

    19 DOTS entries:

    DT.100826053  DT.448969  DT.100028481  DT.100826052  DT.100826049  DT.121249054  DT.100826051  DT.121249018 
    DT.121248934  DT.102826125  DT.121249067  DT.97764093  DT.100711691  DT.100826048  DT.121248782  DT.121249069 
    DT.121249081  DT.100736518  DT.99990673 

    24/292 AceView cDNA sequences (see all 292):

    BI551482 AI857899 AL708595 AA814461 AA707841 BU732569 CA389802 AL708728 
    AI560233 BI757660 AW573005 BI492672 Z38808 AL832808 AA279507 NM_033535 
    BM725650 BU618644 AV724059 AA279508 BG116511 AA481591 AL708585 AA600827 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                  -                             -                                             
    SP2:                                                  -     -                       -                                             
    SP3:                                -                 -     -                       -                                             
    SP4:                                                  -     -                       -                                             
    SP5:                                                  -     -     -                 -                                             


    ECgene alternative splicing isoforms for FBXL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL5 expression in normal human tissues (normalized intensities)      FBXL5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGAAGACT
    FBXL5 Expression
    About this image


    FBXL5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See FBXL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL5

    SOURCE GeneReport for Unigene cluster: Hs.643433
        SABiosciences Expression via Pathway-Focused PCR Array including FBXL5: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXL5 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl51 , 5 F-box and leucine-rich repeat protein 51, 5 90.61(n)1
    93.76(a)1
      5 (23.81 cM)5
    2429601  NM_001159963.11  NP_001153435.11 
     437446165 
    chicken
    (Gallus gallus)
    Aves FBXL51 F-box and leucine-rich repeat protein 5 80.68(n)
    81.17(a)
      422829  XM_420776.3  XP_420776.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL56
    F-box and leucine-rich repeat protein 5
    77(a)
    1 ↔ 1
    4(124067729-124112018)
    African clawed frog
    (Xenopus laevis)
    Amphibia fbxl5-prov2 F-box and leucine-rich repeat protein 5 78.98(n)    BC052101.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb52d062 Danio rerio cDNA clone IMAGE6792653, partial cds 76(n)    BC054590.1 


    ENSEMBL Gene Tree for FBXL5 (if available)
    TreeFam Gene Tree for FBXL5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXL5 gene

    FBXL5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FBXL5
    PGOHUM00000246089


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1192 SNPs in FBXL5 are shown (see all 1192)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs46984081,2
    C,F,A,H--15599604(+) GTCCAA/GTCAAC 4 -- us2k129Minor allele frequency- N:0.00EA NA NS WA CSA 2964
    rs1409124431,2
    --15605536(+) TTCCTC/GACTTC 4 -- ds50010--------
    rs1166366551,2
    --15605702(+) CTGGAA/GTAGCA 4 -- ds50010--------
    rs1445656321,2
    C--15605774(+) GCGTAC/GATTTG 4 -- ds50010--------
    rs1385523801,2
    --15605793(+) TTTTCA/GACATG 4 -- ds50010--------
    rs1834317711,2
    --15605846(+) GTGAGA/GGACAT 4 -- ds50010--------
    rs1161664841,2
    F--15605921(+) ATATTG/ATTGTG 4 -- ds50011Minor allele frequency- A:0.02WA 118
    rs732391671,2
    C,F--15606023(+) TCTCTG/CTCTTA 4 -- ut31 nc-transcript-variant2Minor allele frequency- C:0.14NA 122
    rs1430510991,2
    --15606057(+) CAAAGC/TAATTA 4 -- ut31 nc-transcript-variant0--------
    rs113387801,2
    C--15606153(+) CAATAT/-ACGAG 4 -- ut31 nc-transcript-variant2Minor allele frequency- -:0.00NA 4

    HapMap Linkage Disequilibrium report for FBXL5 (15606007 - 15683302 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXL5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1293360CNV Insertion17803354
    nsv292453CNV Loss16902084
    dgv315n21CNV Loss19592680
    esv26392CNV Gain19812545
    esv27769CNV Gain19812545
    nsv428439CNV Gain+Loss18775914
    dgv1587e1CNV Complex17122850
    dgv1586e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FBXL5 for disorders           About MalaCards
    OMIM gene information: 605655    OMIM disorders: --


    FBXL5 for disorders           About GeneDecksing


    Export disorders for FBXL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL5 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with FBXL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. FBXL5 interacts with p150Glued and regulates its ubiquitination. (PubMed id 17532294)1, 2, 9 Zhang N.... Yao X. (2007)
    3. Structural and molecular characterization of iron-sens ing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL 5). (PubMed id 22253436)1, 2 Thompson J.W....Bruick R.K. (2012)
    4. Control of iron homeostasis by an iron-regulated ubiquitin ligase. (PubMed id 19762596)1, 2 Vashisht A.A.... Wohlschlegel J.A. (2009)
    5. An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. (PubMed id 19762597)1, 2 Salahudeen A.A.... Bruick R.K. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
    9. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
    10. F-box and leucine-rich repeat protein 5 (FBXL5) is req uired for maintenance of cellular and systemic iron homeostasis. (PubMed id 23135277)1 Ruiz J.C....Bruick R.K. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26234 HGNC: 13602 AceView: FBXL5 Ensembl:ENSG00000118564 euGenes: HUgn26234
    ECgene: FBXL5 H-InvDB: FBXL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXL5 gene:
    Search GeneIP for patents involving FBXL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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