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FBXL4 Gene

protein-coding   GIFtS: 50
GCID: GC06M099316

F-Box And Leucine-Rich Repeat Protein 4

  See FBXL4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 41 2 3
FBL42 3 5
FBL52 3
MTDPS132 5
F-Box/LRR-Repeat Protein 42
F-Box Protein FBL4/FBL53

External Ids:    HGNC: 136011   Entrez Gene: 262352   Ensembl: ENSG000001122347   OMIM: 6056545   UniProtKB: Q9UKA23   

Export aliases for FBXL4 gene to outside databases

Previous GC identifers: GC06M099190 GC06M099338 GC06M099367 GC06M099428 GC06M096760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXL4 Gene:
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid
motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF
complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein
interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the
encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the
encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for FBXL4 Gene:
FBXL4 (F-box and leucine-rich repeat protein 4) is a protein-coding gene. Diseases associated with FBXL4 include mitochondrial dna depletion syndrome 13, and mitochondrial dna depletion syndrome. An important paralog of this gene is FBXL2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL4 gene promoter:
         Elk-1   FOXO3   Lmo2   CUTL1   Gfi-1   S8   Pax-3   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL4 promoter sequence
   Search Chromatin IP Primers for FBXL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1-q16.3   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.1-q16.3

FBXL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M099316:  view genomic region     (about GC identifiers)

Start:
99,316,420 bp from pter      End:
99,395,849 bp from pter
Size:
79,430 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBXL4_HUMAN, Q9UKA2 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 4  
Size: 621 amino acids; 70097 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Secondary accessions: E1P530 O95919 Q5BJH0 Q9UJU0

Explore the universe of human proteins at neXtProt for FBXL4: NX_Q9UKA2

Explore proteomics data for FBXL4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115, Lys537
  • Modification sites at PhosphoSitePlus

  • See FBXL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265645.1  NP_036292.2  

    ENSEMBL proteins: 
     ENSP00000358247   ENSP00000229971  

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    Cloud-Clone Corp. Proteins for FBXL4

     
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    antibodies-online proteins for FBXL4 (5 products) 

     
    antibodies-online peptides for FBXL4

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    antibodies-online antibodies for FBXL4 (29 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXL: F-boxes / Leucine-rich repeats

    2 InterPro protein domains:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKA2

    ProtoNet protein and cluster: Q9UKA2

    2 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB006553 Leucine-rich repeat


    UniProtKB/Swiss-Prot: FBXL4_HUMAN, Q9UKA2
    Similarity: Contains 1 F-box domain
    Similarity: Contains 9 LRR (leucine-rich) repeats


    Find genes that share domains with FBXL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FBXL4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FBXL4

    miRNA
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    Block miRNA regulation of human, mouse, rat FBXL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXL4 (see all 14):
    hsa-miR-520e hsa-miR-302d hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-570 hsa-miR-520a-3p hsa-miR-520c-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXL4 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXL4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBXL4_HUMAN, Q9UKA2: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS10531035
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005758mitochondrial intermembrane space IDA--

    Find genes that share ontologies with FBXL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FBXL4: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXL4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for FBXL4 (Q9UKA23 ENSP000002299714) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    XPCENSP000002850214STRING: ENSP00000285021
    POLR2IENSP000002218594STRING: ENSP00000221859
    SUPT4H1ENSP000002255044STRING: ENSP00000225504
    ERCC6ENSP000003480894STRING: ENSP00000348089
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS10531035

    Find genes that share ontologies with FBXL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXL4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXL4 gene (2 alternative transcripts): 
    NM_001278716.1  NM_012160.4  

    Unigene Cluster for FBXL4:

    F-box and leucine-rich repeat protein 4
    Hs.536850  [show with all ESTs]
    Unigene Representative Sequence: BC032641
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369244(uc003ppg.1) ENST00000229971(uc003ppf.1 uc003pph.1 uc010kcp.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FBXL4 (see all 14):
    hsa-miR-520e hsa-miR-302d hsa-miR-302a hsa-miR-302e hsa-miR-373 hsa-miR-570 hsa-miR-520a-3p hsa-miR-520c-3p
    SwitchGear 3'UTR luciferase reporter plasmidFBXL4 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat FBXL4

    Additional mRNA sequence: 

    AF174590.1 AF176699.1 AF199355.1 AJ420594.1 AK308736.1 AK313076.1 BC032641.1 BC039819.1 
    BC055010.1 BC091484.1 

    9 DOTS entries:

    DT.309792  DT.92429196  DT.101980364  DT.95269158  DT.101965755  DT.100021280  DT.95149924  DT.100000882 
    DT.205787 

    Selected AceView cDNA sequences (see all 125):

    AI378575 AW473600 BQ272063 BU194838 AI889955 AA458633 AI690421 AI928419 
    AA713480 CR590319 AI242962 BQ694762 AW770868 R92744 NM_012160 BQ009437 
    AA455537 AL555471 BX363114 AF199355 AI492384 BC055010 BM761662 AI567731 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:              -                                                   


    ECgene alternative splicing isoforms for FBXL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAACTTATT
    FBXL4 Expression
    About this image

    FBXL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.536850

    UniProtKB/Swiss-Prot: FBXL4_HUMAN, Q9UKA2
    Tissue specificity: Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXL4: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXL4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl41 , 5 F-box and leucine-rich repeat protein 41, 5 88.46(n)1
    93.4(a)1
      4 (9.69 cM)5
    2695141  NM_172988.41  NP_766576.11 
     223575435 
    chicken
    (Gallus gallus)
    Aves FBXL41 F-box and leucine-rich repeat protein 4 81.29(n)
    86.61(a)
      421798  XM_004940360.1  XP_004940417.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL46
    F-box and leucine-rich repeat protein 4
    82(a)
    1 ↔ 1
    1(172088627-172150007)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004902651 F-box/LRR-repeat protein 4-like 72.44(n)
    76.54(a)
      100490265  XM_002937469.2  XP_002937515.2 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxl41 F-box and leucine-rich repeat protein 4 64.9(n)
    68.6(a)
      492349  NM_001007315.1  NP_001007316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18393
    Fbxl41
    F box and leucine-rich-repeat gene 41 31(a)3
    44.22(n)1
    35.62(a)1
      12E63
    323781  NM_132723.21  NP_572951.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRR16
    F-box protein component of the SCF ubiquitin-ligas...
    10(a)
    1 → many
    X(590872-594327) YJR090C


    ENSEMBL Gene Tree for FBXL4 (if available)
    TreeFam Gene Tree for FBXL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXL4 gene
    FBXL22  FBXL172  FBXL202  ENSG000002371022  FBXL132  FBXL162  FBXL72  LRRC292  
    FBXL152  FBXL142  

    Find genes that share paralogs with FBXL4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXL4 (see all 1273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708634
    Mitochondrial DNA depletion syndrome 13 (MTDPS13)4--see VAR_0708632 Q P mis40--------
    VAR_0708594
    Mitochondrial DNA depletion syndrome 13 (MTDPS13)4--see VAR_0708592 R W mis40--------
    VAR_0708614
    Mitochondrial DNA depletion syndrome 13 (MTDPS13)4--see VAR_0708612 D G mis40--------
    VAR_0708584
    Mitochondrial DNA depletion syndrome 13 (MTDPS13)4--see VAR_0708582 I T mis40--------
    VAR_0708604
    Mitochondrial DNA depletion syndrome 13 (MTDPS13)4--see VAR_0708602 I N mis40--------
    VAR_0708624
    Mitochondrial DNA depletion syndrome 13 (MTDPS13)4--see VAR_0708622 G A mis40--------
    rs1505018461,2
    --99321126(+) GTACAC/TTACAT 1 -- ds50010--------
    rs1907574551,2
    --99321240(+) GTGTAC/TATATA 1 -- ds50010--------
    rs1398205921,2
    --99321280(+) TATAAC/TTCAGA 1 -- ds50010--------
    rs1415670381,2
    --99321433(+) AAATAC/TCAGAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FBXL4 (99316420 - 99395849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FBXL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732468CNV Deletion23290073
    esv2659264CNV Deletion23128226
    nsv823788CNV Loss20364138
    esv26393CNV Loss19812545

    Human Gene Mutation Database (HGMD): FBXL4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXL4
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605654   
    OMIM disorders: 615471  
    2 diseases for FBXL4:    
    About MalaCards
    mitochondrial dna depletion syndrome 13    mitochondrial dna depletion syndrome


    Find genes that share disorders with FBXL4           About GenesLikeMe


    Export disorders for FBXL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXL4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FBXL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (Genomics 2000)
    5. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    6. Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance. (PubMed id 23993193)1 Bonnen P.E....Taylor R.W. (Am. J. Hum. Genet. 2013)
    7. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PubMed id 24035498)1 Tan M.K....Harper J.W. (Mol. Cell 2013)
    8. Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy. (PubMed id 23993194)1 Gai X....Zeviani M. (Am. J. Hum. Genet. 2013)
    9. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. (PubMed id 21757720)1 Van Rechem C....Whetstine J.R. (J. Biol. Chem. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26235 HGNC: 13601 AceView: FBXL4 Ensembl:ENSG00000112234 euGenes: HUgn26235
    ECgene: FBXL4 H-InvDB: FBXL4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXL4 gene:
    Search GeneIP for patents involving FBXL4

    GeneCards and IP:
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