Aliases for FBXL4 Gene
External Ids for FBXL4 Gene
Previous GeneCards Identifiers for FBXL4 Gene
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for FBXL4 Gene
FBXL4 (F-Box And Leucine Rich Repeat Protein 4) is a Protein Coding gene. Diseases associated with FBXL4 include Mitochondrial Dna Depletion Syndrome 13 and Fbxl4-Related Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL7.