FBXL4 Gene
protein-coding GIFtS: 46
GCID: GC06M099367
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|
F-box and leucine-rich repeat protein 4
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Aliases
for FBXL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 41 2 3 | | FBL41 2 3 5 | | FBL51 2 3 | | F-Box Protein FBL4/FBL52 3 | | F-Box Protein FBL42 | | F-Box/LRR-Repeat Protein 42 |
Export aliases for FBXL4 gene to outside databasesPrevious GC identifers: GC06M099190 GC06M099338 GC06M099428 GC06M096760 |
Summaries
for FBXL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL4:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fblsclass and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats. (provided by RefSeq, Jul 2008)
|
Genomic Views
for FBXL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL4 gene promoter:
Elk-1 FOXO3 Lmo2 CUTL1 Gfi-1 S8 Pax-3 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q16.1-q16.3 Ensembl cytogenetic band: 6q16.1 HGNC cytogenetic band: 6q16.1-q16.3FBXL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M099367: view genomic region
(about GC identifiers)
Start:
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99,321,334 bp from pter |
End:
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99,395,849 bp from pter |
Size:
|
74,516 bases |
Orientation:
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minus strand |
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Proteins
for FBXL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBXL4_HUMAN, Q9UKA2 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 4 Size: 621 amino acids; 70097 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity)
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: E1P530 O95919 Q5BJH0 Q9UJU0Explore the universe of human proteins at neXtProt for FBXL4: NX_Q9UKA2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKA2
FBXL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036292.2
ENSEMBL proteins: ENSP00000358247 ENSP00000229971
Human Recombinant Protein Products for FBXL4:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FBXL4 for ontologies About GeneDecksing
FBXL4 Antibody Products:
Assay Products for FBXL4: |
Protein
Domains /
Families
for FBXL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKA2ProtoNet protein and cluster: Q9UKA2 2 Blocks protein families: IPB001611 Leucine-rich repeat signature IPB006553 Leucine-rich repeat
UniProtKB/Swiss-Prot: FBXL4_HUMAN, Q9UKA2Similarity: Contains 1 F-box domainSimilarity: Contains 9 LRR (leucine-rich) repeats |
Function
for FBXL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FBXL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL4 |
|
Pathways & Interactions
for FBXL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FBXL4 (Q9UKA23 ENSP000002299714) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
TAS | 10531035 |
FBXL4 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL4
Search CenterWatch for drugs/clinical trials and news about FBXL4
|
Transcripts
for FBXL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL4 gene: NM_012160.3 Unigene Cluster for FBXL4: F-box and leucine-rich repeat protein 4 Hs.714504 [show with all ESTs]Unigene Representative Sequence: BC0326412 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369244(uc003ppg.1) ENST00000229971(uc003ppf.1 uc003pph.1 uc010kcp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXL4 (NM_012160) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL4 |
Additional cDNA sequence: AF174590.1 AF176699.1 AF199355.1 AJ420594.1 AK055220.1 AK308736.1 AK313076.1 BC032641.1 BC039819.1 BC055010.1 BC091484.1 9 DOTS entries: DT.309792 DT.100000882 DT.92429196 DT.101980364 DT.95269158 DT.101965755 DT.95149924 DT.100021280 DT.205787 24/125 AceView cDNA sequences (see all 125): AW770868 AF174590 AI492384 AA455537 BQ009437 AI928419 CR590319 BU194838 AI378575 AI690421 BQ272063 R92744 BM761662 AI567731 BC055010 AA458633 AF199355 AI242962 NM_012160 BX363114 AA713480 BQ694762 AI889955 AL555471
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXL4
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Expression
for FBXL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAACTTATT
About this image
See FBXL4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL4
SOURCE GeneReport for Unigene cluster: Hs.714504
UniProtKB/Swiss-Prot: FBXL4_HUMAN, Q9UKA2Tissue specificity: Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including FBXL4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL4 |
Orthologs
for FBXL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FBXL4 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for FBXL4 (if available)
TreeFam Gene Tree for FBXL4 (if available) |
Paralogs
for FBXL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXL4 gene
- FBXL172 FBXL22 FBXL202 ENSG000002371022 FBXL132 FBXL162 FBXL72 AMN12
- LRRC292 FBXL152 FBXL142
FBXL4 for paralogs About GeneDecksing
|
Genomic Variants
for FBXL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL4 (99321334 - 99395849 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBXL4
1 CNV: 64603 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL4 |
|
Disorders
/ Diseases
for FBXL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FBXL4 for disorders About MalaCards
FBXL4 for disorders About GeneDecksing
OMIM gene information: 605654
OMIM disorders: --
Export disorders for FBXL4 gene to outside databases
|
Publications
for FBXL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FBXL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
- A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
- The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji d omain-containing 2A (JMJD2A) protein. (PubMed id 21757720)1 Van Rechem C....Whetstine J.R. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FBXL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL4 gene:
Search GeneIP for patents involving FBXL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL4 |
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