Aliases for FBXL4 Gene
External Ids for FBXL4 Gene
This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for FBXL4 Gene
FBXL4 (F-Box And Leucine-Rich Repeat Protein 4) is a Protein Coding gene. Diseases associated with FBXL4 include mitochondrial dna depletion syndrome 13 and mitochondrial dna depletion syndrome, encephalomyopathic form with variable craniofacial anomalies. An important paralog of this gene is FBXL16.