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Aliases for FBXL3 Gene

Aliases for FBXL3 Gene

  • F-Box And Leucine-Rich Repeat Protein 3 2 3
  • F-Box And Leucine-Rich Repeat Protein 3A 2 3 4
  • FBXL3A 3 4 6
  • FBL3A 3 4 6
  • F-Box/LRR-Repeat Protein 3A 3 4
  • FBL3 3 6
  • F-Box/LRR-Repeat Protein 3 3
  • F-Box Protein Fbl3a 3

External Ids for FBXL3 Gene

Previous HGNC Symbols for FBXL3 Gene

  • FBXL3A

Previous GeneCards Identifiers for FBXL3 Gene

  • GC13M076477
  • GC13M077566
  • GC13M058277

Summaries for FBXL3 Gene

Entrez Gene Summary for FBXL3 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXL3 Gene

FBXL3 (F-Box And Leucine-Rich Repeat Protein 3) is a Protein Coding gene. Diseases associated with FBXL3 include estrogen-receptor positive breast cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Circadian Clock. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL21.

UniProtKB/Swiss-Prot for FBXL3 Gene

  • Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.

Gene Wiki entry for FBXL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL3 Gene

Genomics for FBXL3 Gene

Genomic Location for FBXL3 Gene

Start:
76,992,598 bp from pter
End:
77,027,196 bp from pter
Size:
34,599 bases
Orientation:
Minus strand

Genomic View for FBXL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL3 Gene

Proteins for FBXL3 Gene

  • Protein details for FBXL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT7-FBXL3_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 3
    Protein Accession:
    Q9UKT7
    Secondary Accessions:
    • B2RB04
    • Q9P122

    Protein attributes for FBXL3 Gene

    Size:
    428 amino acids
    Molecular mass:
    48707 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1, RBX1 and FBXL3. Interacts with CRY1 and CRY2 (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for FBXL3 Gene

neXtProt entry for FBXL3 Gene

Proteomics data for FBXL3 Gene at MOPED

Post-translational modifications for FBXL3 Gene

  • Ubiquitination at Lys201 and Lys321
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXL3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL3 Gene

Domains for FBXL3 Gene

Gene Families for FBXL3 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKT7

UniProtKB/Swiss-Prot:

FBXL3_HUMAN :
  • Q9UKT7
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL3: view

Function for FBXL3 Gene

Molecular function for FBXL3 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.

Gene Ontology (GO) - Molecular Function for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding IPI 17463251
genes like me logo Genes that share ontologies with FBXL3: view
genes like me logo Genes that share phenotypes with FBXL3: view

Animal Models for FBXL3 Gene

MGI Knock Outs for FBXL3:

miRNA for FBXL3 Gene

miRTarBase miRNAs that target FBXL3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FBXL3 Gene

Localization for FBXL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL3 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL3 Gene COMPARTMENTS Subcellular localization image for FBXL3 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with FBXL3: view

Pathways for FBXL3 Gene

genes like me logo Genes that share pathways with FBXL3: view

UniProtKB/Swiss-Prot Q9UKT7-FBXL3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007623 circadian rhythm TAS --
GO:0016567 protein ubiquitination NAS 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 17463251
GO:0031648 protein destabilization ISS --
GO:0042752 regulation of circadian rhythm IMP 17463251
genes like me logo Genes that share ontologies with FBXL3: view

Transcripts for FBXL3 Gene

Unigene Clusters for FBXL3 Gene

F-box and leucine-rich repeat protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for FBXL3 Gene

GeneLoc Exon Structure for
FBXL3
ECgene alternative splicing isoforms for
FBXL3

Expression for FBXL3 Gene

mRNA expression in normal human tissues for FBXL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL3 Gene

SOURCE GeneReport for Unigene cluster for FBXL3 Gene Hs.508284

mRNA Expression by UniProt/SwissProt for FBXL3 Gene

Q9UKT7-FBXL3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with FBXL3: view

No data available for mRNA differential expression in normal tissues for FBXL3 Gene

Orthologs for FBXL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL3 35
  • 99.61 (n)
  • 100 (a)
FBXL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL3 35
  • 94.55 (n)
  • 99.77 (a)
FBXL3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl3 35
  • 89.25 (n)
  • 97.2 (a)
Fbxl3 16
Fbxl3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl3 35
  • 88.94 (n)
  • 97.43 (a)
chicken
(Gallus gallus)
Aves FBXL3 35
  • 81.93 (n)
  • 93.69 (a)
lizard
(Anolis carolinensis)
Reptilia FBXL3 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10201 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl3 35
  • 78.89 (n)
  • 90.65 (a)
Str.9980 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14083 35
zebrafish
(Danio rerio)
Actinopterygii fbxl3a 36
  • 84 (a)
OneToMany
fbxl3b 36
  • 56 (a)
OneToMany
LOC504112 35
  • 73.35 (n)
  • 86.63 (a)
Species with no ortholog for FBXL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL3 Gene

ENSEMBL:
Gene Tree for FBXL3 (if available)
TreeFam:
Gene Tree for FBXL3 (if available)

Paralogs for FBXL3 Gene

Paralogs for FBXL3 Gene

Selected SIMAP similar genes for FBXL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXL3: view

Variants for FBXL3 Gene

Sequence variations from dbSNP and Humsavar for FBXL3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs14853 -- 77,005,614(-) CTCCT(A/C/G/T)CAGCA utr-variant-3-prime
rs400258 -- 77,014,021(+) GTTCA(C/G)AGTGT intron-variant
rs420564 -- 77,021,054(-) AATAT(A/G)TTTTA intron-variant
rs432845 -- 77,021,102(+) TTCAT(C/T)TGAAG intron-variant
rs448321 -- 77,013,891(+) CTGTT(C/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL3 Gene

Variant ID Type Subtype PubMed ID
nsv832652 CNV Gain 17160897
nsv832653 CNV Loss 17160897

Relevant External Links for FBXL3 Gene

HapMap Linkage Disequilibrium report
FBXL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL3 Gene

Disorders for FBXL3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FBXL3 Gene including...

Search for FBXL3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FBXL3 Gene

genes like me logo Genes that share disorders with FBXL3: view

No data available for UniProtKB/Swiss-Prot for FBXL3 Gene

Publications for FBXL3 Gene

  1. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 2 3 23
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PMID: 17463251) Busino L. … Pagano M. (Science 2007) 3 4
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for FBXL3 Gene

Sources for FBXL3 Gene

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