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FBXL3 Gene

protein-coding   GIFtS: 57
GCID: GC13M077566

F-Box And Leucine-Rich Repeat Protein 3

(Previous name: F-box and leucine-rich repeat protein 3A)
(Previous symbol: FBXL3A)
  See FBXL3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 31 2     F-Box/LRR-Repeat Protein 3A2 3
FBXL3A1 2 3 5     FBL32 5
F-Box And Leucine-Rich Repeat Protein 3A1 2 3     F-Box Protein Fbl3a2
FBL3A2 3 5     F-Box/LRR-Repeat Protein 32

External Ids:    HGNC: 135991   Entrez Gene: 262242   Ensembl: ENSG000000058127   OMIM: 6056535   UniProtKB: Q9UKT73   

Export aliases for FBXL3 gene to outside databases

Previous GC identifers: GC13M076477 GC13M058277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXL3 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats
and is localized in the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXL3 Gene:
FBXL3 (F-box and leucine-rich repeat protein 3) is a protein-coding gene. Diseases associated with FBXL3 include estrogen-receptor positive breast cancer. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXL21.

UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian
rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock
oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent
degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2

Gene Wiki entry for FBXL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL3 gene promoter:
         Nkx3-1   Nkx3-1 v4   GCNF   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Nkx3-1 v2   GCNF-1   Nkx3-1 v3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL3 promoter sequence
   Search Chromatin IP Primers for FBXL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q22.3   HGNC cytogenetic band: 13q22

FBXL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M077566:  view genomic region     (about GC identifiers)

Start:
77,566,740 bp from pter      End:
77,601,331 bp from pter
Size:
34,592 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 3  
Size: 428 amino acids; 48707 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1,
RBX1 and FBXL3. Interacts with CRY1 and CRY2
1 PDB 3D structure from and Proteopedia for FBXL3:
4I6J (3D)    
Secondary accessions: B2RB04 Q9P122

Explore the universe of human proteins at neXtProt for FBXL3: NX_Q9UKT7

Explore proteomics data for FBXL3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys201, Lys321
  • Modification sites at PhosphoSitePlus

  • See FBXL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036290.1  
    ENSEMBL proteins: 
     ENSP00000347834   ENSP00000412183  
    Reactome Protein details: Q9UKT7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXL: F-boxes / Leucine-rich repeats

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKT7

    ProtoNet protein and cluster: Q9UKT7

    UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 LRR (leucine-rich) repeats


    Find genes that share domains with FBXL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL3_HUMAN, Q9UKT7
    Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian
    rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock
    oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent
    degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
    FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI17463251
         
    Find genes that share ontologies with FBXL3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FBXL3:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased cell death HMECs cel  Increased circadian period len 

         5 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Fbxl3):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  integument  no phenotypic analysis 

    Find genes that share phenotypes with FBXL3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fbxl3tm1.1Ljp for FBXL3

       genOway: Develop your customized and physiologically relevant rodent model for FBXL3

    miRNA
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    miRTarBase miRNAs that target FBXL3:
    hsa-mir-93-5p (MIRT028091), hsa-mir-340-5p (MIRT019641), hsa-mir-186-5p (MIRT021110)

    Block miRNA regulation of human, mouse, rat FBXL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXL3 (see all 33):
    hsa-miR-142-5p hsa-miR-106a hsa-let-7a-2* hsa-miR-374a hsa-miR-3667-5p hsa-miR-9 hsa-miR-93 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidFBXL3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBXL3_HUMAN, Q9UKT7: Nucleus. Cytoplasm. Note=Predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol ISS--
    GO:0019005SCF ubiquitin ligase complex IDA17463251

    Find genes that share ontologies with FBXL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FBXL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    2Circadian Clock
    Circadian Clock0.66
    3Circadian rhythm
    Circadian rhythm0.31
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with FBXL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for FBXL3
        Association of TriC/CCT with target proteins during biosynthesis
    Circadian Clock


    1 Kegg Pathway  (Kegg details for FBXL3):
        Circadian rhythm

    UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXL3: 

              Circadian Rhythms in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXL3 (Q9UKT72, 3 ENSP000003478344) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
    CRY1Q165263, ENSP000000085274I2D: score=1 STRING: ENSP00000008527
    CRY2Q49AN03, ENSP000004067514I2D: score=1 STRING: ENSP00000406751
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA17463251
    GO:0042752regulation of circadian rhythm IMP17463251
    GO:0043153entrainment of circadian clock by photoperiod ISS--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process ----

    Find genes that share ontologies with FBXL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FBXL3 gene: 
    NM_012158.2  

    Unigene Cluster for FBXL3:

    F-box and leucine-rich repeat protein 3
    Hs.508284  [show with all ESTs]
    Unigene Representative Sequence: NM_012158
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485797 ENST00000477982 ENST00000355619(uc001vkd.3) ENST00000417323
    ENST00000470210 ENST00000472949
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FBXL3 (see all 33):
    hsa-miR-142-5p hsa-miR-106a hsa-let-7a-2* hsa-miR-374a hsa-miR-3667-5p hsa-miR-9 hsa-miR-93 hsa-miR-526b*
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      QuantiTect SYBR Green Assays in human, mouse, rat FBXL3
      QuantiFast Probe-based Assays in human, mouse, rat FBXL3

    Additional mRNA sequence: 

    AF126028.1 AF129532.1 AK025484.1 AK314442.1 AL833187.1 BC063796.1 BC072448.1 

    15 DOTS entries:

    DT.447214  DT.75169715  DT.120781368  DT.75180488  DT.120781353  DT.120781356  DT.120781363  DT.120781399 
    DT.120781401  DT.70103308  DT.75150425  DT.95146296  DT.99992278  DT.95241428  DT.95264712 

    Selected AceView cDNA sequences (see all 202):

    AA748914 BM721586 Z39951 BM696524 BQ424398 AI356716 CF594324 BU951829 
    BU754202 BF574334 CD677408 AW511185 AW339612 BU190174 AA488914 CA407367 
    BQ050755 AI474918 AI866697 CB216156 AI017436 BU431633 AI133484 AA648533 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXL3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
    SP1:                          -                                                               
    SP2:                          -     -     -     -                                             
    SP3:                          -                 -                                             
    SP4:              -     -     -                                                               
    SP5:                    -     -                                                               


    ECgene alternative splicing isoforms for FBXL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGTAGAG
    FBXL3 Expression
    About this image


    FBXL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    FBXL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508284

    UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FBXL3: 
              Circadian Rhythms in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FBXL3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl31 , 5 F-box and leucine-rich repeat protein 31, 5 89.25(n)1
    97.2(a)1
      14 (51.73 cM)5
    507891  NM_015822.21  NP_056637.11 
     1030802395 
    chicken
    (Gallus gallus)
    Aves FBXL31 F-box and leucine-rich repeat protein 3 81.93(n)
    93.69(a)
      428048  XM_425611.4  XP_425611.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL36
    F-box and leucine-rich repeat protein 3
    89(a)
    1 ↔ 1
    3(86642479-86647794)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102012 Xenopus laevis transcribed sequence with strong similarity more 81.52(n)    48057668 
    zebrafish
    (Danio rerio)
    Actinopterygii 570584702   -- 70.85(n)    57058470 


    ENSEMBL Gene Tree for FBXL3 (if available)
    TreeFam Gene Tree for FBXL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXL3 gene
    FBXL212  
    1 SIMAP similar gene for FBXL3 using alignment to 2 protein entries:     FBXL3_HUMAN (see all proteins):
    FBXL21

    Find genes that share paralogs with FBXL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXL3 (see all 515)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs571618171,2
    C--58478946(+) AAAGAC/TATTTA 1 -- ds50014Minor allele frequency- T:0.06WA NA EA 360
    rs1511828331,2
    --58478981(+) AAGGAC/TCCTTA 1 -- ds50010--------
    rs1826239591,2
    --58479048(+) AAGAAC/GCTATT 1 -- ds50010--------
    rs1403193071,2
    --58479123(+) GGCATC/TAGAGC 1 -- ds50010--------
    rs115494641,2
    C,F--58479574(+) TAGAAG/AGAGGG 1 -- ut31 trp32Minor allele frequency- A:0.10NA EA 240
    rs1872539701,2
    --58479584(+) GGATAC/TATTAC 1 -- ut310--------
    rs148531,2
    C,F--58479648(-) CTCCTA/GCAGCA 1 -- ut31 ese35Minor allele frequency- G:0.06MN NA EA 428
    rs1910472581,2
    --58479679(+) AAGCAA/GAAATT 1 -- ut310--------
    rs6449191,2
    C,H--58479762(-) TGGTTA/GAGGAA 1 -- ut31 ese312Minor allele frequency- G:0.00NA WA CSA EA 376
    rs6449161,2
    C,H--58479766(-) TCAGTA/GGTTGA 1 -- ut31 ese312Minor allele frequency- G:0.01NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for FBXL3 (77566740 - 77601331 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832653CNV Loss17160897
    nsv832652CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXL3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605653    OMIM disorders: --

    1 disease for FBXL3:    
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    estrogen-receptor positive breast cancer

    1 disease from the University of Copenhagen DISEASES database for FBXL3:
    estrogen-receptor positive breast cancer

    Find genes that share disorders with FBXL3           About GenesLikeMe


    Export disorders for FBXL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXL3 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FBXL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PubMed id 10828603)1, 3, 9 Chiaur D.S....Pagano M. (Cytogenet. Cell Genet. 2000)
    3. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PubMed id 17463251)1, 2 Busino L.... Pagano M. (Science 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. (PubMed id 23503662)1 Xing W....Zheng N. (Nature 2013)
    6. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. (PubMed id 23452855)2 Yoo S.H.... Takahashi J.S. (Cell 2013)
    7. Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. (PubMed id 23616524)1 Anand S.N....Nolan P.M. (J. Neurosci. 2013)
    8. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PubMed id 23453757)1 Pierce N.W....Deshaies R.J. (Cell 2013)
    9. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. (PubMed id 24085301)1 Yumimoto K....Nakayama K.I. (J. Biol. Chem. 2013)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26224 HGNC: 13599 AceView: FBXL3 Ensembl:ENSG00000005812 euGenes: HUgn26224
    ECgene: FBXL3 Kegg: 26224 H-InvDB: FBXL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXL3 gene:
    Search GeneIP for patents involving FBXL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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