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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL3 Gene

protein-coding   GIFtS: 55
GCID: GC13M077566

F-Box And Leucine-Rich Repeat Protein 3

(Previous name: F-box and leucine-rich repeat protein 3A)
(Previous symbol: FBXL3A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And Leucine-Rich Repeat Protein 31 2     F-Box/LRR-Repeat Protein 3A2 3
FBXL3A1 2 3 5     FBL32 5
F-Box And Leucine-Rich Repeat Protein 3A1 2 3     F-Box Protein Fbl3a2
FBL3A2 3 5     F-Box/LRR-Repeat Protein 32

External Ids:    HGNC: 135991   Entrez Gene: 262242   Ensembl: ENSG000000058127   OMIM: 6056535   UniProtKB: Q9UKT73   

Export aliases for FBXL3 gene to outside databases

Previous GC identifers: GC13M076477 GC13M058277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXL3 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats
and is localized in the nucleus. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBXL3 Gene: 
FBXL3 (F-box and leucine-rich repeat protein 3) is a protein-coding gene. Diseases associated with FBXL3 include estrogen-receptor positive breast cancer, and breast cancer, and among its related super-pathways are Circadian Clock and Chaperonin-mediated protein folding. GO annotations related to this gene include ubiquitin-protein ligase activity and protein binding.

UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian
rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock
oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent
degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2

Gene Wiki entry for FBXL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL3 gene promoter:
         Nkx3-1   Nkx3-1 v4   GCNF   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Nkx3-1 v2   GCNF-1   Nkx3-1 v3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q22.3   HGNC cytogenetic band: 13q22

FBXL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M077566:  view genomic region     (about GC identifiers)

Start:
77,566,740 bp from pter      End:
77,601,331 bp from pter
Size:
34,592 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 3  
Size: 428 amino acids; 48707 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1,
RBX1 and FBXL3. Interacts with CRY1 and CRY2
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear
1 PDB 3D structure from and Proteopedia for FBXL3:
4I6J (3D)    
Secondary accessions: B2RB04 Q9P122

Explore the universe of human proteins at neXtProt for FBXL3: NX_Q9UKT7

Explore proteomics data for FBXL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKT7

  • FBXL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXL3 Protein Expression
    REFSEQ proteins: NP_036290.1  
    ENSEMBL proteins: 
     ENSP00000347834   ENSP00000412183  
    Reactome Protein details: Q9UKT7
    Human Recombinant Protein Products for FBXL3: 
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    Cloud-Clone Corp. Proteins for FBXL3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS10531035
    GO:0005634nucleus ISS--
    GO:0005829cytosol ISS--
    GO:0019005SCF ubiquitin ligase complex IDA17463251

    FBXL3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXL: F-boxes / Leucine-rich repeats

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9UKT7

    ProtoNet protein and cluster: Q9UKT7

    UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
    Similarity: Contains 1 F-box domain
    Similarity: Contains 7 LRR (leucine-rich) repeats


    FBXL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL3_HUMAN, Q9UKT7
    Function: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian
    rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock
    oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent
    degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
    FBXL3 probably recognizes and binds phosphorylated CRY1 and CRY2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity NAS10531035
    GO:0005515protein binding IPI17463251
         
    FBXL3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FBXL3:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a  Increased cell death HMECs cel  Increased circadian period len 

         5 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Fbxl3):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  integument  no phenotypic analysis 

    FBXL3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fbxl3tm1.1Ljp for FBXL3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL3 
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    SwitchGear 3'UTR luciferase reporter plasmidFBXL3 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBXL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.40
    Circadian rhythm0.35
    2Chaperonin-mediated protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.60
    Protein folding0.91
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for FBXL3
        Association of TriC/CCT with target proteins during biosynthesis
    Chaperonin-mediated protein folding
    Circadian Clock
    Metabolism of proteins
    Protein folding


    1         Kegg Pathway  (Kegg details for FBXL3):
        Circadian rhythm

    UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
    Pathway: Protein modification; protein ubiquitination


    FBXL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for FBXL3 (Q9UKT72, 3 ENSP000003478344) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKP1P632083, ENSP000002314874I2D: score=3 STRING: ENSP00000231487
    CRY1Q165263, ENSP000000085274I2D: score=1 STRING: ENSP00000008527
    CRY2Q49AN03, ENSP000004067514I2D: score=1 STRING: ENSP00000406751
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination NAS10531035
    GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA17463251
    GO:0042752regulation of circadian rhythm IMP17463251
    GO:0043153entrainment of circadian clock by photoperiod ISS--
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process ----

    FBXL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about FBXL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for FBXL3 gene: 
    NM_012158.2  

    Unigene Cluster for FBXL3:

    F-box and leucine-rich repeat protein 3
    Hs.508284  [show with all ESTs]
    Unigene Representative Sequence: NM_012158
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485797 ENST00000477982 ENST00000355619(uc001vkd.3) ENST00000417323
    ENST00000470210 ENST00000472949
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    Additional mRNA sequence: 

    AF126028.1 AF129532.1 AK025484.1 AK314442.1 AL833187.1 BC063796.1 BC072448.1 

    15 DOTS entries:

    DT.447214  DT.75169715  DT.120781368  DT.75180488  DT.120781353  DT.120781356  DT.120781363  DT.120781399 
    DT.120781401  DT.70103308  DT.75150425  DT.95146296  DT.99992278  DT.95241428  DT.95264712 

    24/202 AceView cDNA sequences (see all 202):

    AA287383 BU754202 BU431633 CB216156 AA905463 BQ050755 BU951829 CF594324 
    BX281018 T25856 BF574334 AA488914 CA407367 BM721586 AW511185 CA388641 
    BM696524 Z39951 AW339612 BU190174 Z43904 AI017436 BQ424398 AI474918 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
    SP1:                          -                                                               
    SP2:                          -     -     -     -                                             
    SP3:                          -                 -                                             
    SP4:              -     -     -                                                               
    SP5:                    -     -                                                               


    ECgene alternative splicing isoforms for FBXL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL3 expression in normal human tissues (normalized intensities)      FBXL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGTAGAG
    FBXL3 Expression
    About this image


    FBXL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             trachea   
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood

    See FBXL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL3

    SOURCE GeneReport for Unigene cluster: Hs.508284

    UniProtKB/Swiss-Prot: FBXL3_HUMAN, Q9UKT7
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including FBXL3: 
              Circadian Rhythms in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FBXL3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl31 , 5 F-box and leucine-rich repeat protein 31, 5 89.25(n)1
    97.2(a)1
      14 (51.73 cM)5
    507891  NM_015822.21  NP_056637.11 
     1030802395 
    chicken
    (Gallus gallus)
    Aves FBXL31 F-box and leucine-rich repeat protein 3 81.93(n)
    93.69(a)
      428048  XM_425611.3  XP_425611.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL36
    Uncharacterized protein
    89(a)
    1 ↔ 1
    3(86642479-86647794)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.102012 Xenopus laevis transcribed sequence with strong similarity more 81.52(n)    48057668 
    zebrafish
    (Danio rerio)
    Actinopterygii 570584702   -- 70.85(n)    57058470 


    ENSEMBL Gene Tree for FBXL3 (if available)
    TreeFam Gene Tree for FBXL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXL3 gene
    1 SIMAP similar gene for FBXL3 using alignment to 2 protein entries:     FBXL3_HUMAN (see all proteins):
    FBXL21

    FBXL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/515 SNPs in FBXL3 are shown (see all 515)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs571618171,2
    C--58478946(+) AAAGAC/TATTTA 1 -- ds50014Minor allele frequency- T:0.06WA NA EA 360
    rs1511828331,2
    --58478981(+) AAGGAC/TCCTTA 1 -- ds50010--------
    rs1826239591,2
    --58479048(+) AAGAAC/GCTATT 1 -- ds50010--------
    rs1403193071,2
    --58479123(+) GGCATC/TAGAGC 1 -- ds50010--------
    rs115494641,2
    C,F--58479574(+) TAGAAG/AGAGGG 1 -- ut31 trp32Minor allele frequency- A:0.10NA EA 240
    rs1872539701,2
    --58479584(+) GGATAC/TATTAC 1 -- ut310--------
    rs148531,2
    C,F--58479648(-) CTCCTA/GCAGCA 1 -- ut31 ese35Minor allele frequency- G:0.06MN NA EA 428
    rs1910472581,2
    --58479679(+) AAGCAA/GAAATT 1 -- ut310--------
    rs6449191,2
    C,H--58479762(-) TGGTTA/GAGGAA 1 -- ut31 ese312Minor allele frequency- G:0.00NA WA CSA EA 376
    rs6449161,2
    C,H--58479766(-) TCAGTA/GGTTGA 1 -- ut31 ese312Minor allele frequency- G:0.01NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for FBXL3 (77566740 - 77601331 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832653CNV Loss17160897
    nsv832652CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605653    OMIM disorders: --

    2 diseases for FBXL3:    About MalaCards
    estrogen-receptor positive breast cancer    breast cancer

    1 disease from the University of Copenhagen DISEASES database for FBXL3:
    estrogen-receptor positive breast cancer

    FBXL3 for disorders           About GeneDecksing


    Export disorders for FBXL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with FBXL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PubMed id 10828603)1, 3, 9 Chiaur D.S....Pagano M. (2000)
    3. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PubMed id 17463251)1, 2 Busino L....Pagano M. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. SCF(FBXL3) ubiquitin ligase targets cryptochromes at t heir cofactor pocket. (PubMed id 23503662)1 Xing W....Zheng N. (2013)
    6. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. (PubMed id 23452855)2 Yoo S.H.... Takahashi J.S. (2013)
    7. Distinct and separable roles for endogenous CRY1 and C RY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. (PubMed id 23616524)1 Anand S.N....Nolan P.M. (2013)
    8. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PubMed id 23453757)1 Pierce N.W....Deshaies R.J. (2013)
    9. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    10. Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing bTrCP. (PubMed id 22975506)1 Sasajima H....Yokosawa H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26224 HGNC: 13599 AceView: FBXL3 Ensembl:ENSG00000005812 euGenes: HUgn26224
    ECgene: FBXL3 Kegg: 26224 H-InvDB: FBXL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXL3 gene:
    Search GeneIP for patents involving FBXL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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