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Aliases for FBXL3 Gene

Aliases for FBXL3 Gene

  • F-Box And Leucine Rich Repeat Protein 3 2 3 5
  • F-Box And Leucine-Rich Repeat Protein 3A 2 3 4
  • F-Box/LRR-Repeat Protein 3A 3 4
  • FBXL3A 3 4
  • FBL3A 3 4
  • F-Box/LRR-Repeat Protein 3 3
  • F-Box Protein Fbl3a 3
  • FBL3 3

External Ids for FBXL3 Gene

Previous HGNC Symbols for FBXL3 Gene

  • FBXL3A

Previous GeneCards Identifiers for FBXL3 Gene

  • GC13M076477
  • GC13M077566
  • GC13M058277

Summaries for FBXL3 Gene

Entrez Gene Summary for FBXL3 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBXL3 Gene

FBXL3 (F-Box And Leucine Rich Repeat Protein 3) is a Protein Coding gene. Among its related pathways are Immune System and BMAL1-CLOCK,NPAS2 activates circadian gene expression. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXL3 Gene

  • Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).

Gene Wiki entry for FBXL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL3 Gene

Genomics for FBXL3 Gene

Regulatory Elements for FBXL3 Gene

Enhancers for FBXL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F077025 1 ENCODE 15 +0.4 356 3.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 GLIS2 ELK1 ZNF207 KLF7 FBXL3 MYCBP2-AS2 CLN5 MYCBP2-AS1
GH13F076990 1.1 ENCODE 14.5 +34.5 34455 3.8 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 DEK FBXL3 CLN5 ENSG00000283208 MYCBP2-AS1
GH13F077696 0.4 ENCODE 12.1 -670.6 -670635 3.5 HDGF PKNOX1 ZNF76 SIN3A FEZF1 GLIS2 EGR1 ZNF366 SCRT2 ZNF143 CLN5 FBXL3 RPL31P54 SLAIN1 LOC100129307
GH13F077065 1.2 Ensembl 11.3 -38.2 -38205 0.4 SPI1 FBXL3 MYCBP2 CLN5 MYCBP2-AS2 ENSG00000274898
GH13F077022 0.5 Ensembl 11 +4.1 4096 1.8 MYNN PRDM10 ZNF24 ZNF600 MYCBP2-AS2 FBXL3 MYCBP2 MYCBP2-AS1 ENSG00000283208
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FBXL3 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000517950 896 3401 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 GLIS2 ZNF207 KLF7 KLF13

Genomic Location for FBXL3 Gene

Chromosome:
13
Start:
76,992,598 bp from pter
End:
77,027,196 bp from pter
Size:
34,599 bases
Orientation:
Minus strand

Genomic View for FBXL3 Gene

Genes around FBXL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL3 Gene

Proteins for FBXL3 Gene

  • Protein details for FBXL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT7-FBXL3_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 3
    Protein Accession:
    Q9UKT7
    Secondary Accessions:
    • B2RB04
    • Q9P122

    Protein attributes for FBXL3 Gene

    Size:
    428 amino acids
    Molecular mass:
    48707 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL3) composed of CUL1, SKP1, RBX1 and FBXL3. Interacts with CRY1 and CRY2 (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for FBXL3 Gene

neXtProt entry for FBXL3 Gene

Post-translational modifications for FBXL3 Gene

  • Ubiquitination at Lys 201 and Lys 321
  • Modification sites at PhosphoSitePlus

Other Protein References for FBXL3 Gene

No data available for DME Specific Peptides for FBXL3 Gene

Domains & Families for FBXL3 Gene

Gene Families for FBXL3 Gene

Protein Domains for FBXL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKT7

UniProtKB/Swiss-Prot:

FBXL3_HUMAN :
  • Contains 1 F-box domain.
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL3: view

Function for FBXL3 Gene

Molecular function for FBXL3 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).

Gene Ontology (GO) - Molecular Function for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,NAS 10531035
GO:0005515 protein binding IPI 17463251
genes like me logo Genes that share ontologies with FBXL3: view
genes like me logo Genes that share phenotypes with FBXL3: view

Animal Models for FBXL3 Gene

MGI Knock Outs for FBXL3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL3 Gene

Localization for FBXL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL3 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL3 Gene COMPARTMENTS Subcellular localization image for FBXL3 gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,ISS --
GO:0019005 SCF ubiquitin ligase complex IDA 17463251
genes like me logo Genes that share ontologies with FBXL3: view

Pathways & Interactions for FBXL3 Gene

genes like me logo Genes that share pathways with FBXL3: view

UniProtKB/Swiss-Prot Q9UKT7-FBXL3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 17463251
GO:0031648 protein destabilization IEA,ISS --
GO:0042752 regulation of circadian rhythm IMP 17463251
GO:0043153 entrainment of circadian clock by photoperiod IEA,ISS --
genes like me logo Genes that share ontologies with FBXL3: view

No data available for SIGNOR curated interactions for FBXL3 Gene

Transcripts for FBXL3 Gene

Unigene Clusters for FBXL3 Gene

F-box and leucine-rich repeat protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for FBXL3 Gene

GeneLoc Exon Structure for
FBXL3
ECgene alternative splicing isoforms for
FBXL3

Expression for FBXL3 Gene

mRNA expression in normal human tissues for FBXL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL3 Gene

This gene is overexpressed in Testis (24.6), Ovary (20.1), Gallbladder (15.0), and Blymphocyte (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL3 Gene



Protein tissue co-expression partners for FBXL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL3 Gene:

FBXL3

SOURCE GeneReport for Unigene cluster for FBXL3 Gene:

Hs.508284

mRNA Expression by UniProt/SwissProt for FBXL3 Gene:

Q9UKT7-FBXL3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with FBXL3: view

Primer Products

No data available for mRNA differential expression in normal tissues for FBXL3 Gene

Orthologs for FBXL3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL3 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia FBXL3 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL3 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL3 34 35
  • 94.55 (n)
mouse
(Mus musculus)
Mammalia Fbxl3 34 16 35
  • 89.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL3 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl3 34
  • 88.94 (n)
chicken
(Gallus gallus)
Aves FBXL3 34
  • 81.93 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL3 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl3 34
  • 78.89 (n)
Str.9980 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10201 34
zebrafish
(Danio rerio)
Actinopterygii fbxl3a 35
  • 84 (a)
OneToMany
LOC504112 34
  • 73.35 (n)
fbxl3b 35
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14083 34
Species where no ortholog for FBXL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL3 Gene

ENSEMBL:
Gene Tree for FBXL3 (if available)
TreeFam:
Gene Tree for FBXL3 (if available)

Paralogs for FBXL3 Gene

(1) SIMAP similar genes for FBXL3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FBXL3 Gene

genes like me logo Genes that share paralogs with FBXL3: view

No data available for Paralogs for FBXL3 Gene

Variants for FBXL3 Gene

Sequence variations from dbSNP and Humsavar for FBXL3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs104894385 Pathogenic 76,992,176(+) TCCTG(A/G/T)TGCTG downstream-variant-500B, reference, missense, stop-gained
rs104894386 Pathogenic 76,995,077(+) CTTCC(A/C/G)TCCAA intron-variant, reference, missense
rs121908292 Pathogenic 77,000,799(+) CTAAA(G/T)AATTT intron-variant, reference, utr-variant-3-prime, stop-gained
rs148862100 Pathogenic 77,000,866(+) GTTTT(A/G)TAATT intron-variant, reference, missense, utr-variant-3-prime
rs267606738 Pathogenic 76,995,119(+) TTTCT(A/G)TCCAA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FBXL3 Gene

Variant ID Type Subtype PubMed ID
esv3550733 CNV deletion 23714750
nsv477135 CNV novel sequence insertion 20440878
nsv832652 CNV gain 17160897
nsv832653 CNV loss 17160897

Variation tolerance for FBXL3 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL3 Gene

Disorders for FBXL3 Gene

Relevant External Links for FBXL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL3

No disorders were found for FBXL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL3 Gene

Publications for FBXL3 Gene

  1. Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. (PMID: 10828603) Chiaur D.S. … Pagano M. (Cytogenet. Cell Genet. 2000) 2 3 22 64
  2. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  3. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PMID: 17463251) Busino L. … Pagano M. (Science 2007) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation. (PMID: 27565346) Scott D.C. … Schulman B.A. (Cell 2016) 4 64

Products for FBXL3 Gene

Sources for FBXL3 Gene

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