Aliases for FBXL3 Gene
External Ids for FBXL3 Gene
Previous HGNC Symbols for FBXL3 Gene
Previous GeneCards Identifiers for FBXL3 Gene
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. [provided by RefSeq, Jul 2008]
GeneCards Summary for FBXL3 Gene
FBXL3 (F-Box And Leucine-Rich Repeat Protein 3) is a Protein Coding gene. Diseases associated with FBXL3 include estrogen-receptor positive breast cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Circadian Clock. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL21.
UniProtKB/Swiss-Prot for FBXL3 Gene
Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.