Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXL22 Gene

Aliases for FBXL22 Gene

  • F-Box And Leucine-Rich Repeat Protein 22 2 3 5
  • F-Box/LRR-Repeat Protein 22 3
  • Fbl22 3

External Ids for FBXL22 Gene

Previous GeneCards Identifiers for FBXL22 Gene

  • GC15P061676
  • GC15P063889
  • GC15P040715
  • GC15P063597
  • GC15P063773

Summaries for FBXL22 Gene

Entrez Gene Summary for FBXL22 Gene

  • This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]

GeneCards Summary for FBXL22 Gene

FBXL22 (F-Box And Leucine-Rich Repeat Protein 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL22 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL22 Gene

Genomics for FBXL22 Gene

Regulatory Elements for FBXL22 Gene

Genomic Location for FBXL22 Gene

Chromosome:
15
Start:
63,594,830 bp from pter
End:
63,602,428 bp from pter
Size:
7,599 bases
Orientation:
Plus strand

Genomic View for FBXL22 Gene

Genes around FBXL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL22 Gene

Proteins for FBXL22 Gene

  • Protein details for FBXL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P050-FXL22_HUMAN
    Recommended name:
    F-box and leucine-rich protein 22
    Protein Accession:
    Q6P050

    Protein attributes for FBXL22 Gene

    Size:
    247 amino acids
    Molecular mass:
    27269 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH65833.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FBXL22 Gene

Proteomics data for FBXL22 Gene at MOPED

Post-translational modifications for FBXL22 Gene

No Post-translational modifications

Other Protein References for FBXL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL22 Gene

Domains & Families for FBXL22 Gene

Gene Families for FBXL22 Gene

Protein Domains for FBXL22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P050

UniProtKB/Swiss-Prot:

FXL22_HUMAN :
  • Contains 1 F-box domain.
Domain:
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXL22: view

Function for FBXL22 Gene

Molecular function for FBXL22 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).

Phenotypes for FBXL22 Gene

genes like me logo Genes that share phenotypes with FBXL22: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL22 Gene

Localization for FBXL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL22 Gene

Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL22 Gene COMPARTMENTS Subcellular localization image for FBXL22 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019005 SCF ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with FBXL22: view

Pathways & Interactions for FBXL22 Gene

SuperPathways for FBXL22 Gene

No Data Available

UniProtKB/Swiss-Prot Q6P050-FXL22_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for FBXL22 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353794%0d%0a9606.ENSP00000327145%0d%0a9606.ENSP00000355537%0d%0a9606.ENSP00000326804%0d%0a9606.ENSP00000231487%0d%0a
Selected Interacting proteins: ENSP00000353794 for FBXL22 Gene via STRING

Gene Ontology (GO) - Biological Process for FBXL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXL22: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL22 Gene

Drugs & Compounds for FBXL22 Gene

No Compound Related Data Available

Transcripts for FBXL22 Gene

Unigene Clusters for FBXL22 Gene

F-box and leucine-rich repeat protein 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL22 Gene

No ASD Table

Relevant External Links for FBXL22 Gene

GeneLoc Exon Structure for
FBXL22
ECgene alternative splicing isoforms for
FBXL22

Expression for FBXL22 Gene

mRNA expression in normal human tissues for FBXL22 Gene

mRNA differential expression in normal tissues according to GTEx for FBXL22 Gene

This gene is overexpressed in Colon - Sigmoid (x6.5), Uterus (x4.7), and Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for FBXL22 Gene

This gene is overexpressed in Colon (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL22 Gene



SOURCE GeneReport for Unigene cluster for FBXL22 Gene Hs.631163

mRNA Expression by UniProt/SwissProt for FBXL22 Gene

Q6P050-FXL22_HUMAN
Tissue specificity: Enriched in cardiac muscle.
genes like me logo Genes that share expression patterns with FBXL22: view

Protein tissue co-expression partners for FBXL22 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FBXL22 Gene

Orthologs for FBXL22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL22 35
  • 99.44 (n)
  • 99.16 (a)
cow
(Bos Taurus)
Mammalia FBXL22 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL22 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl22 36
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL22 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL22 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbxl22 36
  • 37 (a)
OneToOne
Species with no ortholog for FBXL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL22 Gene

ENSEMBL:
Gene Tree for FBXL22 (if available)
TreeFam:
Gene Tree for FBXL22 (if available)

Paralogs for FBXL22 Gene

No data available for Paralogs for FBXL22 Gene

Variants for FBXL22 Gene

Sequence variations from dbSNP and Humsavar for FBXL22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_033940 -
rs531125217 -- 63,602,853(+) GAGCA(C/G)AGTGA downstream-variant-500B
rs536418394 -- 63,602,898(+) AGCAA(C/T)GCAGC downstream-variant-500B
rs576519109 -- 63,602,848(+) GGCTG(A/G)AGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FBXL22 Gene

Variant ID Type Subtype PubMed ID
nsv833034 CNV Loss 17160897
nsv827357 CNV Gain 20364138

Variation tolerance for FBXL22 Gene

Residual Variation Intolerance Score: 65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL22 Gene

HapMap Linkage Disequilibrium report
FBXL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL22 Gene

Disorders for FBXL22 Gene

Relevant External Links for FBXL22

Genetic Association Database (GAD)
FBXL22
Human Genome Epidemiology (HuGE) Navigator
FBXL22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL22

No disorders were found for FBXL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL22 Gene

Publications for FBXL22 Gene

  1. F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. (PMID: 22972877) Spaich S. … Frey N. (Circ. Res. 2012) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for FBXL22 Gene

Sources for FBXL22 Gene

Back to Top

Content