Aliases for FBXL22 Gene
Aliases for FBXL22 Gene
External Ids for FBXL22 Gene
- HGNC: 27537
- Entrez Gene: 283807
- Ensembl: ENSG00000197361
- OMIM: 609088
- UniProtKB: Q6P050
Previous GeneCards Identifiers for FBXL22 Gene
- GC15P061676
- GC15P063889
- GC15P040715
- GC15P063597
- GC15P063773
- GC15P064268
- GC15P066289
- GC15P066838
Summaries for FBXL22 Gene
-
This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
GeneCards Summary for FBXL22 Gene
FBXL22 (F-Box And Leucine Rich Repeat Protein 22) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot for FBXL22 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL22 Gene
Genomics for FBXL22 Gene
Regulatory Elements for FBXL22 Gene
Enhancers for FBXL22 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL22 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXL22 gene promoter:
Regulatory Element Products
Genomic Location for FBXL22 Gene
- Chromosome:
- 15
- Start:
- 63,594,830 bp from pter
- End:
- 63,602,428 bp from pter
- Size:
- 7,599 bases
- Orientation:
- Plus strand
Genomic View for FBXL22 Gene
Genes around FBXL22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q22.31 by Ensembl
- 15q22.31 by Entrez Gene
- 15q22.31 by HGNC
FBXL22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL22 Gene
Proteins for FBXL22 Gene
-
Protein details for FBXL22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P050-FXL22_HUMAN
- Recommended name:
- F-box and leucine-rich protein 22
- Protein Accession:
- Q6P050
Protein attributes for FBXL22 Gene
- Size:
- 247 amino acids
- Molecular mass:
- 27269 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=AAH65833.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for FBXL22 Gene
Post-translational modifications for FBXL22 Gene
No Post-translational modifications
Other Protein References for FBXL22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL22
- Invitrogen Antibodies for FBXL22
- antibodies-online Antibodies for FBXL22: See all 5
- Search GeneTex for Antibodies for FBXL22
Protein Products
-
OriGene Purified Proteins for FBXL22
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL22
- Origene Custom Protein Services for FBXL22
- antibodies-online Proteins for FBXL22: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL22
Assay Products
- antibodies-online Kits for FBXL22: See all 21
No data available for DME Specific Peptides for FBXL22 Gene
Domains & Families for FBXL22 Gene
Gene Families for FBXL22 Gene
Suggested Antigen Peptide Sequences for FBXL22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL22 Gene
Function for FBXL22 Gene
Molecular function for FBXL22 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0061630 | ubiquitin protein ligase activity | IDA | 22972877 |
Phenotypes for FBXL22 Gene
- GenomeRNAi human phenotypes for FBXL22:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL22 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for FBXL22
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL22
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miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL22
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL22 gene
Clone Products
-
OriGene ORF clones in human for FBXL22
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Cell Line Products
-
Horizon Cell Lines for FBXL22
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL22 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL22 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL22 Gene
Localization for FBXL22 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL22 Gene
- Cytoplasm, myofibril, sarcomere, Z line.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IEA | -- |
| GO:0030018 | Z disc | IEA | -- |
Pathways & Interactions for FBXL22 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL22 Gene
4 Reactome pathways for FBXL22 Gene
UniProtKB/Swiss-Prot Q6P050-FXL22_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXL22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IDA | 22972877 |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL22 Gene
Transcripts for FBXL22 Gene
mRNA/cDNA for FBXL22 Gene
- (7) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (23) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL22 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL22
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL22
- GenScript: Design CRISPR guide RNA sequences for FBXL22
miRNA Products
- Search ViGene Biosciences for FBXL22
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL22
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL22 gene
Clone Products
-
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Expression for FBXL22 Gene
mRNA differential expression in normal tissues according to GTEx for FBXL22 Gene
This gene is overexpressed in Colon - Sigmoid (x6.5), Uterus (x4.7), and Artery - Tibial (x4.2).
This gene is overexpressed in Colon (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL22 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL22 Gene:
FBXL22SOURCE GeneReport for Unigene cluster for FBXL22 Gene:
Hs.631163mRNA Expression by UniProt/SwissProt for FBXL22 Gene:
Q6P050-FXL22_HUMAN
Tissue specificity:
Enriched in cardiac muscle.
Primer Products
-
OriGene qPCR primer pairs for FBXL22
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL22 Gene
Orthologs for FBXL22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL22 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL22 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXL22 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fbxl22 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FBXL22 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXL22 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | fbxl22 35 |
|
OneToOne |
- Species where no ortholog for FBXL22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL22 Gene
No data available for Paralogs for FBXL22 Gene
Variants for FBXL22 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000069419 | -- | 63,602,675(+) | CAAGA(C/G)ATTGG | intron-variant, upstream-variant-2KB | |
| rs1000312275 | -- | 63,597,993(+) | AAGAA(C/G)TGGGG | intron-variant, utr-variant-5-prime | |
| rs1000695375 | -- | 63,608,160(+) | CTGAG(A/G)CATGT | intron-variant, downstream-variant-500B | |
| rs1000861474 | -- | 63,604,224(+) | AACAA(C/G)GGAAC | intron-variant | |
| rs1001126449 | -- | 63,596,444(+) | AAAGG(C/T)AAAGA | intron-variant, upstream-variant-2KB, utr-variant-5-prime |
Residual Variation Intolerance Score:
65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.41;
63.79% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXL22 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL22
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL22 Gene
Disorders for FBXL22 Gene
Relevant External Links for FBXL22
No disorders were found for FBXL22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL22 Gene
Publications for FBXL22 Gene
- F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. (PMID: 22972877) Spaich S. … Frey N. (Circ. Res. 2012) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4 64
- Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3 64
Products for FBXL22 Gene
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- OriGene Purified Proteins for FBXL22
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- Novus Biologicals Antibodies for FBXL22
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- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FBXL22: See all 5
- antibodies-online Kits for FBXL22: See all 21
- antibodies-online Proteins for FBXL22: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for FBXL22
- Search GeneTex for Proteins for FBXL22
- ViGene Biosciences adenoviral particle packaged cDNA for FBXL22 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXL22 gene
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- Horizon Cell Lines for FBXL22
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXL22
- VectorBuilder custom plasmid, inducible vectors for FBXL22
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer