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Aliases for FBXL22 Gene

Aliases for FBXL22 Gene

  • F-Box And Leucine-Rich Repeat Protein 22 2 3
  • Fbl22 3 6
  • F-Box And Leucine-Rich Protein 22 3
  • F-Box/LRR-Repeat Protein 22 3

External Ids for FBXL22 Gene

Previous GeneCards Identifiers for FBXL22 Gene

  • GC15P061676
  • GC15P063889
  • GC15P040715

Summaries for FBXL22 Gene

Entrez Gene Summary for FBXL22 Gene

  • This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]

GeneCards Summary for FBXL22 Gene

FBXL22 (F-Box And Leucine-Rich Repeat Protein 22) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL22 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL22 Gene

Genomics for FBXL22 Gene

Regulatory Elements for FBXL22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL22 Gene

63,597,128 bp from pter
63,602,428 bp from pter
5,301 bases
Plus strand

Genomic View for FBXL22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL22 Gene

Proteins for FBXL22 Gene

  • Protein details for FBXL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box and leucine-rich protein 22
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FBXL22 Gene

    247 amino acids
    Molecular mass:
    27269 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=AAH65833.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FBXL22 Gene

Proteomics data for FBXL22 Gene at MOPED

Post-translational modifications for FBXL22 Gene

No Post-translational modifications

Other Protein References for FBXL22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL22 Gene

Domains for FBXL22 Gene

Gene Families for FBXL22 Gene

  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL22 Gene


Suggested Antigen Peptide Sequences for FBXL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6P050
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXL22: view

Function for FBXL22 Gene

Molecular function for FBXL22 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).

Gene Ontology (GO) - Molecular Function for FBXL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL22: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXL22 Gene

Localization for FBXL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL22 Gene

Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

Jensen Localization Image for FBXL22 Gene COMPARTMENTS Subcellular localization image for FBXL22 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FBXL22: view

Pathways for FBXL22 Gene

SuperPathways for FBXL22 Gene

No Data Available

UniProtKB/Swiss-Prot Q6P050-FXL22_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for FBXL22 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000353794 for FBXL22 Gene via STRING

Gene Ontology (GO) - Biological Process for FBXL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXL22: view

No data available for Pathways by source for FBXL22 Gene

Transcripts for FBXL22 Gene

Unigene Clusters for FBXL22 Gene

F-box and leucine-rich repeat protein 22:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL22

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FBXL22
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL22 Gene

No ASD Table

Relevant External Links for FBXL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL22 Gene

mRNA expression in normal human tissues for FBXL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL22 Gene

This gene is overexpressed in Colon - Sigmoid (6.5), Uterus (4.7), and Artery - Tibial (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXL22 Gene

SOURCE GeneReport for Unigene cluster for FBXL22 Gene Hs.631163

mRNA Expression by UniProt/SwissProt for FBXL22 Gene

Tissue specificity: Enriched in cardiac muscle.
genes like me logo Genes that share expressions with FBXL22: view

In Situ Assay Products

Orthologs for FBXL22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL22 35
  • 99.44 (n)
  • 99.16 (a)
(Bos Taurus)
Mammalia FBXL22 36
  • 54 (a)
(Canis familiaris)
Mammalia FBXL22 36
  • 50 (a)
(Mus musculus)
Mammalia Fbxl22 16
Fbxl22 36
  • 49 (a)
(Monodelphis domestica)
Mammalia FBXL22 36
  • 36 (a)
(Gallus gallus)
Aves FBXL22 36
  • 42 (a)
(Danio rerio)
Actinopterygii fbxl22 36
  • 37 (a)
Species with no ortholog for FBXL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL22 Gene

Gene Tree for FBXL22 (if available)
Gene Tree for FBXL22 (if available)

Paralogs for FBXL22 Gene

No data available for Paralogs for FBXL22 Gene

Variants for FBXL22 Gene

Sequence variations from dbSNP and Humsavar for FBXL22 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs531125217 -- 63,602,853(+) GAGCA(C/G)AGTGA downstream-variant-500B
rs536418394 -- 63,602,898(+) AGCAA(C/T)GCAGC downstream-variant-500B
rs576519109 -- 63,602,848(+) GGCTG(A/G)AGCAG downstream-variant-500B
VAR_033940 -

Structural Variations from Database of Genomic Variants (DGV) for FBXL22 Gene

Variant ID Type Subtype PubMed ID
nsv833034 CNV Loss 17160897
nsv827357 CNV Gain 20364138

Relevant External Links for FBXL22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL22 Gene

Disorders for FBXL22 Gene

Relevant External Links for FBXL22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FBXL22: view

No data available for UniProtKB/Swiss-Prot for FBXL22 Gene

Publications for FBXL22 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo. (PMID: 22972877) Spaich S. … Frey N. (Circ. Res. 2012) 3 4
  5. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3 4

Products for FBXL22 Gene

Sources for FBXL22 Gene

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