FBXL21 Gene
protein-coding GIFtS: 43
GCID: GC05P135293
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F-box and leucine-rich repeat protein 21 (gene/pseudogene)(Previous names: F-box and leucine-rich repeat protein 3 pseudogene, F-box...)
(Previous symbols: FBXL3B, FBXL3P)
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Aliases
for FBXL21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 21 (Gene/Pseudogene)1 2 | | F-Box And Leucine-Rich Repeat Protein 3B2 3 | | FBXL3B1 2 3 | | F-Box/LRR-Repeat Protein 3B2 3 | | FBXL3P1 2 3 | | F-Box Protein Fbl3b2 | | FBL3B1 2 | | F-Box/LRR-Repeat Protein 212 | | Fbl211 2 | | FBL213 | | F-Box And Leucine-Rich Repeat Protein 3 Pseudogene1 2 | | FBL33 | | F-Box And Leucine-Rich Repeat Protein 211 3 | | |
Export aliases for FBXL21 gene to outside databasesPrevious GC identifer: GC05P130454 |
Summaries
for FBXL21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL21:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fblsclass and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The amino acid sequence of this protein ishighly similar to that of f-box and leucine-rich repeat protein 3A. Comparisons of this gene to orthologous sequencessuggest that it may be a pseudogene, and may no longer express a functional protein.(provided by RefSeq, Aug 2009)
UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexinvolved in circadian pacemaker function. The SCF(FBXL21) complex acts by mediating ubiquitination and subsequentdegradation of CRY1. Probable clock-controlled protein that plays a specific role in suprachiasmatic nucleus, SCN andpacemaker function (By similarity)
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Genomic Views
for FBXL21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL21 gene promoter:
Nkx3-1 COUP-TF1 AML1a COUP Nkx2-5 HNF-4alpha2 LCR-F1 HNF-4alpha1 AREB6 COUP-TF
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31FBXL21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P135293: view genomic region
(about GC identifiers)
Start:
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135,266,006 bp from pter |
End:
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135,287,280 bp from pter |
Size:
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21,275 bases |
Orientation:
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plus strand |
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Proteins
for FBXL21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 21 Size: 434 amino acids; 49152 Da
Subunit: Interacts with CRY1 (By similarity). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts withSKP1 and CUL1Explore the universe of human proteins at neXtProt for FBXL21: NX_Q9UKT6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKT6
FBXL21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036291.2
ENSEMBL proteins: ENSP00000425963
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
FBXL21 for ontologies About GeneDecksing
FBXL21 Antibody Products:
Assay Products for FBXL21: |
Protein
Domains /
Families
for FBXL21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL21 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UKT6ProtoNet protein and cluster: Q9UKT6 UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6Similarity: Contains 1 F-box domainSimilarity: Contains 7 LRR (leucine-rich) repeats |
Function
for FBXL21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexinvolved in circadian pacemaker function. The SCF(FBXL21) complex acts by mediating ubiquitination and subsequentdegradation of CRY1. Probable clock-controlled protein that plays a specific role in suprachiasmatic nucleus, SCN andpacemaker function (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL21 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
NAS | 10531035 |
FBXL21 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FBXL21:
|
Pathways & Interactions
for FBXL21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL21
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
FBXL21 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXL21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL21
Search CenterWatch for drugs/clinical trials and news about FBXL21 / FXL21
|
Transcripts
for FBXL21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL21 gene: NM_012159.4 Unigene Cluster for FBXL21: F-box and leucine-rich repeat protein 21 (gene/pseudogene) Hs.591275 [show with all ESTs]Unigene Representative Sequence: NM_0121597 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495672 ENST00000475169 ENST00000472159 ENST00000467490(uc003lbc.3)
ENST00000297158(uc021ydv.1 uc021ydw.1) ENST00000478939(uc021ydx.1)
ENST00000498734
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL21 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXL21 (NM_012159) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL21 |
Additional cDNA sequence: AF129533.1 BC106753.2 3 DOTS entries: DT.91741594 DT.95142207 DT.95239338 10 AceView cDNA sequences: NM_012159 AF129533 BX093224 AV645740 BC044938 AV645509 BI763801 AA700647 W90022 W88455
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL21 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXL21
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Expression
for FBXL21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FBXL21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL21
SOURCE GeneReport for Unigene cluster: Hs.591275
SABiosciences Expression via Pathway-Focused PCR Array including FBXL21:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL21
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL21 |
Orthologs
for FBXL21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FBXL21 gene from 3/6 species (see all 6) About this table
ENSEMBL Gene Tree for FBXL21 (if available)
TreeFam Gene Tree for FBXL21 (if available) |
Paralogs
for FBXL21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FBXL21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL21 (135266006 - 135287280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBXL21
1 CNV: 3577 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL21 |
|
Disorders
/ Diseases
for FBXL21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXL21 for disorders About GeneDecksing
OMIM gene information: 609087
OMIM disorders: --
3  diseases for FBXL21: About MalaCardshepatitis b hepatitis schizophrenia
Human Genome Epidemiology (HuGE) Navigator: FBXL21 (3 documents)
Export disorders for FBXL21 gene to outside databases
|
Publications
for FBXL21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FBXL21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- FBXL21 association with schizophrenia in irish family and case-control samples. (PubMed id 18404645)1 Chen X....Kendler K.S. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FBXL21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL21 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL21 gene:
Search GeneIP for patents involving FBXL21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBXL21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXL21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL21 | | | OriGene Protein Over-expression Lysate for FBXL21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBXL21 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL21 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL21 |
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