Aliases for FBXL21 Gene
External Ids for FBXL21 Gene
Previous HGNC Symbols for FBXL21 Gene
Previous GeneCards Identifiers for FBXL21 Gene
This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017]
GeneCards Summary for FBXL21 Gene
FBXL21 (F-Box And Leucine Rich Repeat Protein 21 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXL21 Gene
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).