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Aliases for FBXL21 Gene

Aliases for FBXL21 Gene

  • F-Box And Leucine Rich Repeat Protein 21 (Gene/Pseudogene) 2 3 5
  • F-Box And Leucine-Rich Repeat Protein 21 2 3 4
  • F-Box And Leucine-Rich Repeat Protein 3 Pseudogene 2 3
  • F-Box And Leucine-Rich Repeat Protein 3B 3 4
  • F-Box/LRR-Repeat Protein 3B 3 4
  • FBXL3B 3 4
  • FBXL3P 3 4
  • Fbl21 3 4
  • F-Box And Leucine-Rich Repeat Protein 21 (Gene/Pseudogene) 2
  • F-Box/LRR-Repeat Protein 21 3
  • F-Box Protein Fbl3b 3
  • FBL3B 3
  • FBL3 4

External Ids for FBXL21 Gene

Previous HGNC Symbols for FBXL21 Gene

  • FBXL3B
  • FBXL3P

Previous GeneCards Identifiers for FBXL21 Gene

  • GC05P135293
  • GC05P130454
  • GC05P135267

Summaries for FBXL21 Gene

Entrez Gene Summary for FBXL21 Gene

  • This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017]

GeneCards Summary for FBXL21 Gene

FBXL21 (F-Box And Leucine Rich Repeat Protein 21 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for FBXL21 Gene

  • Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

Additional gene information for FBXL21 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL21 Gene

Genomics for FBXL21 Gene

GeneHancer (GH) Regulatory Elements for FBXL21 Gene

Promoters and enhancers for FBXL21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I135930 Enhancer 0.8 ENCODE 550.8 0.0 -30 0.2 ARID4B SIN3A ZNF2 ZNF335 GLIS2 ZSCAN5C SP3 SP5 MXD4 ZNF398 FBXL21 LECT2 IL9 ENSG00000254239 ENSG00000253927
GH05I135977 Enhancer 1.2 Ensembl ENCODE dbSUPER 6 +47.7 47663 1.2 PKNOX1 FOXA2 RB1 SIN3A BRCA1 RAD21 YY1 ZNF143 RCOR1 CREM LECT2 FBXL21 GC05P136002
GH05I135945 Enhancer 0.8 ENCODE 6.2 +14.8 14840 0.1 ELF3 SOX13 CTCF SAP130 RB1 ARID4B MAX ZNF2 RAD21 TEAD3 IL9 ENSG00000254239 FBXL21 LECT2
GH05I136004 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +76.1 76065 4.5 FOXA2 JUN SIN3A CEBPG ZIC2 RAD21 RARA HIC1 POLR2A SMC3 TGFBI FBXL21 GC05P136010 GC05P136002
GH05I135954 Promoter 0.8 EPDnew 0.3 +24.7 24685 0.1 TAF1 HNF4A REST RAD21 YY1 LECT2 FBXL21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL21 gene promoter:

Genomic Locations for FBXL21 Gene

Genomic Locations for FBXL21 Gene
chr5:135,930,317-135,951,591
(GRCh38/hg38)
Size:
21,275 bases
Orientation:
Plus strand
chr5:135,266,006-135,287,280
(GRCh37/hg19)

Genomic View for FBXL21 Gene

Genes around FBXL21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL21 Gene

Proteins for FBXL21 Gene

  • Protein details for FBXL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT6-FXL21_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 21
    Protein Accession:
    Q9UKT6

    Protein attributes for FBXL21 Gene

    Size:
    434 amino acids
    Molecular mass:
    49152 Da
    Quaternary structure:
    • Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21.

neXtProt entry for FBXL21 Gene

Post-translational modifications for FBXL21 Gene

No Post-translational modifications

Other Protein References for FBXL21 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for FBXL21 Gene

Domains & Families for FBXL21 Gene

Gene Families for FBXL21 Gene

Protein Domains for FBXL21 Gene

Suggested Antigen Peptide Sequences for FBXL21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL21: view

No data available for UniProtKB/Swiss-Prot for FBXL21 Gene

Function for FBXL21 Gene

Molecular function for FBXL21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

Gene Ontology (GO) - Molecular Function for FBXL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXL21: view
genes like me logo Genes that share phenotypes with FBXL21: view

Animal Models for FBXL21 Gene

MGI Knock Outs for FBXL21:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL21 Gene

Localization for FBXL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL21 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for FBXL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with FBXL21: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FBXL21 Gene

Pathways & Interactions for FBXL21 Gene

genes like me logo Genes that share pathways with FBXL21: view

UniProtKB/Swiss-Prot Q9UKT6-FXL21_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for FBXL21 Gene

Gene Ontology (GO) - Biological Process for FBXL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0016567 protein ubiquitination NAS 10531035
GO:0043153 entrainment of circadian clock by photoperiod ISS --
GO:0043687 post-translational protein modification TAS --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with FBXL21: view

No data available for SIGNOR curated interactions for FBXL21 Gene

Drugs & Compounds for FBXL21 Gene

No Compound Related Data Available

Transcripts for FBXL21 Gene

mRNA/cDNA for FBXL21 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXL21 Gene

F-box and leucine-rich repeat protein 21 (gene/pseudogene):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for FBXL21 Gene

GeneLoc Exon Structure for
FBXL21
ECgene alternative splicing isoforms for
FBXL21

Expression for FBXL21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL21 Gene

This gene is overexpressed in Liver (x18.6) and Prostate (x4.8).

Protein differential expression in normal tissues from HIPED for FBXL21 Gene

This gene is overexpressed in Cerebral cortex (48.5) and Cardia (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXL21 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXL21 Gene:

FBXL21

SOURCE GeneReport for Unigene cluster for FBXL21 Gene:

Hs.591275
genes like me logo Genes that share expression patterns with FBXL21: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL21 Gene

Orthologs for FBXL21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL21 33
  • 97.47 (n)
dog
(Canis familiaris)
Mammalia FBXL21 33 34
  • 88.63 (n)
cow
(Bos Taurus)
Mammalia FBXL21 33 34
  • 88.17 (n)
mouse
(Mus musculus)
Mammalia Fbxl21 33 16 34
  • 80.95 (n)
chicken
(Gallus gallus)
Aves FBXL21 33 34
  • 74.38 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL21 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489356 33
  • 72.58 (n)
zebrafish
(Danio rerio)
Actinopterygii FBXL21 34
  • 72 (a)
OneToOne
fbxl3 33
  • 69.3 (n)
Species where no ortholog for FBXL21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL21 Gene

ENSEMBL:
Gene Tree for FBXL21 (if available)
TreeFam:
Gene Tree for FBXL21 (if available)

Paralogs for FBXL21 Gene

(1) SIMAP similar genes for FBXL21 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXL21: view

No data available for Paralogs for FBXL21 Gene

Variants for FBXL21 Gene

Sequence variations from dbSNP and Humsavar for FBXL21 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000459770 -- 135,937,242(+) A/T intron_variant
rs1000467742 -- 135,929,460(+) C/G/T upstream_transcript_variant
rs1000522898 -- 135,942,155(+) G/A downstream_transcript_variant
rs1000710586 -- 135,929,247(+) C/T upstream_transcript_variant
rs1000764538 -- 135,934,339(+) T/TT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL21 Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850
nsv471050 CNV loss 18288195
nsv477858 CNV novel sequence insertion 20440878

Additional Variant Information for FBXL21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FBXL21 Gene

Disorders for FBXL21 Gene

Additional Disease Information for FBXL21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FBXL21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL21 Gene

Publications for FBXL21 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  3. FBXL21 association with schizophrenia in Irish family and case-control samples. (PMID: 18404645) Chen X … Kendler KS (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. (PMID: 25225294) Zhu X … Liu S (The Journal of biological chemistry 2014) 3 58

Products for FBXL21 Gene

Sources for FBXL21 Gene

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