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Aliases for FBXL21 Gene

Aliases for FBXL21 Gene

  • F-Box And Leucine-Rich Repeat Protein 21 (Gene/Pseudogene) 2 3
  • F-Box And Leucine-Rich Repeat Protein 3B 2 3 4
  • FBXL3B 3 4 6
  • Fbl21 3 4 6
  • F-Box And Leucine-Rich Repeat Protein 3 Pseudogene 2 3
  • F-Box And Leucine-Rich Repeat Protein 21 2 4
  • F-Box/LRR-Repeat Protein 3B 3 4
  • FBXL3P 3 4
  • FBL3B 3 6
  • F-Box/LRR-Repeat Protein 21 3
  • F-Box Protein Fbl3b 3
  • FBL3 4

External Ids for FBXL21 Gene

Previous HGNC Symbols for FBXL21 Gene

  • FBXL3B
  • FBXL3P

Previous GeneCards Identifiers for FBXL21 Gene

  • GC05P135293
  • GC05P130454
  • GC05P135267

Summaries for FBXL21 Gene

Entrez Gene Summary for FBXL21 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The amino acid sequence of this protein is highly similar to that of f-box and leucine-rich repeat protein 3A. Comparisons of this gene to orthologous sequences suggest that it may be a pseudogene, and may no longer express a functional protein.[provided by RefSeq, Aug 2009]

GeneCards Summary for FBXL21 Gene

FBXL21 (F-Box And Leucine-Rich Repeat Protein 21 (Gene/Pseudogene)) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL3.

UniProtKB/Swiss-Prot for FBXL21 Gene

  • Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL21 Gene

Genomics for FBXL21 Gene

Regulatory Elements for FBXL21 Gene

Genomic Location for FBXL21 Gene

Start:
135,930,317 bp from pter
End:
135,951,591 bp from pter
Size:
21,275 bases
Orientation:
Plus strand

Genomic View for FBXL21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL21 Gene

Proteins for FBXL21 Gene

  • Protein details for FBXL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKT6-FXL21_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 21
    Protein Accession:
    Q9UKT6
    Secondary Accessions:

    Protein attributes for FBXL21 Gene

    Size:
    434 amino acids
    Molecular mass:
    49152 Da
    Quaternary structure:
    • Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21.

neXtProt entry for FBXL21 Gene

Proteomics data for FBXL21 Gene at MOPED

Post-translational modifications for FBXL21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL21 Gene

Domains for FBXL21 Gene

Gene Families for FBXL21 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL21 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKT6

UniProtKB/Swiss-Prot:

FXL21_HUMAN :
  • Q9UKT6
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL21: view

Function for FBXL21 Gene

Molecular function for FBXL21 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

Gene Ontology (GO) - Molecular Function for FBXL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL21: view

Phenotypes for FBXL21 Gene

MGI mutant phenotypes for FBXL21:
inferred from 2 alleles
GenomeRNAi human phenotypes for FBXL21:
genes like me logo Genes that share phenotypes with FBXL21: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL21

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXL21 Gene

Localization for FBXL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL21 Gene

Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for FBXL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus ISS --
GO:0005829 cytosol ISS --
GO:0019005 SCF ubiquitin ligase complex ISS --
genes like me logo Genes that share ontologies with FBXL21: view

No data available for Subcellular locations from COMPARTMENTS for FBXL21 Gene

Pathways for FBXL21 Gene

SuperPathways for FBXL21 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UKT6-FXL21_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for FBXL21 Gene

Gene Ontology (GO) - Biological Process for FBXL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0043153 entrainment of circadian clock by photoperiod ISS --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with FBXL21: view

No data available for Pathways by source for FBXL21 Gene

Transcripts for FBXL21 Gene

mRNA/cDNA for FBXL21 Gene

(10) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBXL21 Gene

F-box and leucine-rich repeat protein 21 (gene/pseudogene):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL21

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for FBXL21 Gene

GeneLoc Exon Structure for
FBXL21
ECgene alternative splicing isoforms for
FBXL21

Expression for FBXL21 Gene

mRNA expression in normal human tissues for FBXL21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL21 Gene

This gene is overexpressed in Liver (18.6) and Prostate (4.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for FBXL21 Gene

SOURCE GeneReport for Unigene cluster for FBXL21 Gene Hs.591275

genes like me logo Genes that share expressions with FBXL21: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FBXL21 Gene

Orthologs for FBXL21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL21 35
  • 97.47 (n)
  • 96.77 (a)
cow
(Bos Taurus)
Mammalia FBXL21 35
  • 88.17 (n)
  • 82.95 (a)
FBXL21 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL21 35
  • 88.63 (n)
  • 87.56 (a)
FBXL21 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl21 35
  • 80.95 (n)
  • 85.94 (a)
Fbxl21 16
Fbxl21 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL21 35
  • 74.38 (n)
  • 75 (a)
FBXL21 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL21 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489356 35
  • 72.58 (n)
  • 76.27 (a)
zebrafish
(Danio rerio)
Actinopterygii FBXL21 36
  • 72 (a)
OneToOne
fbxl3 35
  • 69.3 (n)
  • 78.37 (a)
Species with no ortholog for FBXL21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL21 Gene

ENSEMBL:
Gene Tree for FBXL21 (if available)
TreeFam:
Gene Tree for FBXL21 (if available)

Paralogs for FBXL21 Gene

Paralogs for FBXL21 Gene

Selected SIMAP similar genes for FBXL21 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FBXL21: view

Variants for FBXL21 Gene

Sequence variations from dbSNP and Humsavar for FBXL21 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs28792 -- 135,935,673(-) CGCAA(C/T)TAAGT utr-variant-5-prime
rs31546 -- 135,941,814(-) TCCAT(C/T)ACGAC downstream-variant-500B
rs31547 -- 135,941,158(-) ACAAC(A/G)TCAAT synonymous-codon, reference
rs31548 -- 135,941,012(-) TTGGG(A/G)AAAAT intron-variant
rs31549 -- 135,940,360(-) GTTTC(C/T)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL21 Gene

Variant ID Type Subtype PubMed ID
dgv1853e1 CNV Complex 17122850
dgv6338n71 CNV Loss 21882294
nsv471050 CNV Loss 18288195

Relevant External Links for FBXL21 Gene

HapMap Linkage Disequilibrium report
FBXL21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL21 Gene

Disorders for FBXL21 Gene

Relevant External Links for FBXL21

Genetic Association Database (GAD)
FBXL21
Human Genome Epidemiology (HuGE) Navigator
FBXL21
genes like me logo Genes that share disorders with FBXL21: view

No data available for UniProtKB/Swiss-Prot for FBXL21 Gene

Publications for FBXL21 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. FBXL21 association with schizophrenia in Irish family and case-control samples. (PMID: 18404645) Chen X. … Kendler K.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 48
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for FBXL21 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FBXL21
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL21
    • Block miRNA regulation of FBXL21 using miScript Target Protectors

    Sources for FBXL21 Gene

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