Aliases for FBXL21 Gene
Aliases for FBXL21 Gene
External Ids for FBXL21 Gene
- HGNC: 13600
- Entrez Gene: 26223
- Ensembl: ENSG00000164616
- OMIM: 609087
- UniProtKB: Q9UKT6
Previous HGNC Symbols for FBXL21 Gene
- FBXL3B
- FBXL3P
Previous GeneCards Identifiers for FBXL21 Gene
- GC05P135293
- GC05P130454
- GC05P135267
Summaries for FBXL21 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The amino acid sequence of this protein is highly similar to that of f-box and leucine-rich repeat protein 3A. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Jul 2015]
GeneCards Summary for FBXL21 Gene
FBXL21 (F-Box And Leucine Rich Repeat Protein 21 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for FBXL21 Gene
-
Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL21 Gene
Genomics for FBXL21 Gene
Regulatory Elements for FBXL21 Gene
Enhancers for FBXL21 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G135977 | 1.3 | Ensembl ENCODE dbSUPER | 6 | +47.7 | 47663 | 1.2 | PKNOX1 RB1 SIN3A BRCA1 RAD21 YY1 ZNF143 RCOR1 CREM DEK | LECT2 FBXL21 GC05P136002 |
| GH05G135945 | 0.8 | ENCODE | 6.2 | +14.8 | 14840 | 0.1 | ELF3 SOX13 CTCF SAP130 ARID4B MAX ZNF2 RAD21 TEAD3 GATAD1 | ENSG00000254239 IL9 FBXL21 LECT2 |
| GH05G136004 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 1.5 | +76.1 | 76066 | 4.5 | FOXA2 JUN SIN3A CEBPG RAD21 ZIC2 RARA HIC1 POLR2A SMC3 | TGFBI FBXL21 GC05P136002 GC05P136010 |
| GH05G135930 | 0.9 | ENCODE | 0.7 | 0.0 | -31 | 0.2 | ARID4B SIN3A ZNF2 GLIS2 ZSCAN5C SP3 SP5 MXD4 ZEB2 ZNF398 | LECT2 IL9 ENSG00000254239 FBXL21 ENSG00000253927 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL21 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXL21 gene promoter:
Regulatory Element Products
Genomic Location for FBXL21 Gene
- Chromosome:
- 5
- Start:
- 135,930,317 bp from pter
- End:
- 135,951,591 bp from pter
- Size:
- 21,275 bases
- Orientation:
- Plus strand
Genomic View for FBXL21 Gene
Genes around FBXL21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by Ensembl
- 5q31.1 by Entrez Gene
- 5q31.1 by HGNC
FBXL21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL21 Gene
Proteins for FBXL21 Gene
-
Protein details for FBXL21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKT6-FXL21_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 21
- Protein Accession:
- Q9UKT6
Protein attributes for FBXL21 Gene
- Size:
- 434 amino acids
- Molecular mass:
- 49152 Da
- Quaternary structure:
-
- Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21.
Protein Expression for FBXL21 Gene
Post-translational modifications for FBXL21 Gene
Other Protein References for FBXL21 Gene
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL21
- antibodies-online Antibodies for FBXL21: See all 21
- Search GeneTex for Antibodies for FBXL21
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXL21
Protein Products
-
OriGene Purified Proteins for FBXL21
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL21
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- antibodies-online Proteins for FBXL21: See all 8
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- Search GeneTex for Proteins for FBXL21
Assay Products
- antibodies-online Kits for FBXL21: See all 33
No data available for DME Specific Peptides for FBXL21 Gene
Domains & Families for FBXL21 Gene
Gene Families for FBXL21 Gene
Protein Domains for FBXL21 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL21 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL21 Gene
Function for FBXL21 Gene
Molecular function for FBXL21 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXL21 Gene
- MGI mutant phenotypes for FBXL21:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FBXL21:
Animal Model Products
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-
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-
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-
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-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL21 Gene
Localization for FBXL21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL21 Gene
- Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus (By similarity). {ECO:0000250}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | NAS | 10531035 |
| GO:0005634 | nucleus | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | ISS | -- |
No data available for Subcellular locations from COMPARTMENTS for FBXL21 Gene
Pathways & Interactions for FBXL21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL21 Gene
4 Reactome pathways for FBXL21 Gene
UniProtKB/Swiss-Prot Q9UKT6-FXL21_HUMAN
- Pathway: Protein modification; protein ubiquitination.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0016567 | protein ubiquitination | NAS | 10531035 |
| GO:0043153 | entrainment of circadian clock by photoperiod | ISS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0048511 | rhythmic process | IEA | -- |
No data available for SIGNOR curated interactions for FBXL21 Gene
Transcripts for FBXL21 Gene
mRNA/cDNA for FBXL21 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (10) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL21 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL21
-
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miRNA Products
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Inhibitory RNA Products
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-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||
| SP4: |
Expression for FBXL21 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for FBXL21 Gene
This gene is overexpressed in Liver (x18.6) and Prostate (x4.8).
This gene is overexpressed in Cerebral cortex (48.5) and Cardia (20.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FBXL21 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL21 Gene:
FBXL21SOURCE GeneReport for Unigene cluster for FBXL21 Gene:
Hs.591275Primer Products
-
OriGene qPCR primer pairs for FBXL21
-
OriGene qPCR primer pairs and template standards for FBXL21
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL21 Gene
Orthologs for FBXL21 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL21 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL21 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL21 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl21 16 35 34 |
|
||
| chicken (Gallus gallus) |
Aves | FBXL21 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL21 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100489356 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | FBXL21 35 |
|
OneToOne | |
| fbxl3 34 |
|
- Species where no ortholog for FBXL21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL21 Gene
(1) SIMAP similar genes for FBXL21 Gene using alignment to 2 proteins:
No data available for Paralogs for FBXL21 Gene
Variants for FBXL21 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000459770 | -- | 135,937,242(+) | TTGTC(A/T)TCATC | intron-variant | |
| rs1000467742 | -- | 135,929,460(+) | GAGTT(C/G)AAGAC | upstream-variant-2KB | |
| rs1000522898 | -- | 135,942,155(+) | CTTGT(A/G)ATTCA | downstream-variant-500B | |
| rs1000710586 | -- | 135,929,247(+) | TGTGA(C/T)CTTGA | upstream-variant-2KB | |
| rs1000764538 | -- | 135,934,338(+) | TGTGG(-/T)TATTT | intron-variant |
Relevant External Links for FBXL21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL21
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FBXL21 Gene
Disorders for FBXL21 Gene
Relevant External Links for FBXL21
No disorders were found for FBXL21 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL21 Gene
Publications for FBXL21 Gene
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
- FBXL21 association with schizophrenia in Irish family and case-control samples. (PMID: 18404645) Chen X. … Kendler K.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008) 3 46 64
- Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. (PMID: 25225294) Zhu X. … Liu S. (J. Biol. Chem. 2014) 3 64
- Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. (PMID: 24085301) Yumimoto K. … Nakayama K.I. (J. Biol. Chem. 2013) 3 64
Products for FBXL21 Gene
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- antibodies-online Antibodies for FBXL21: See all 21
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL21 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
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- (148) SNPedia
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- (151) CIViC
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer