Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FBXL21 Gene

protein-coding   GIFtS: 45
GCID: GC05P135267

F-Box And Leucine-Rich Repeat Protein 21 (Gene/Pseudogene)

(Previous names: F-box and leucine-rich repeat protein 3 pseudogene, F-box...)
(Previous symbols: FBXL3B, FBXL3P)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
F-Box And Leucine-Rich Repeat Protein 21 (Gene/Pseudogene)1 2     FBL3B2 5
FBXL3B1 2 3 5     FBL213 5
FBXL3P1 2 3     Fbl212
F-Box And Leucine-Rich Repeat Protein 3B1 2 3     F-Box Protein Fbl3b2
F-Box And Leucine-Rich Repeat Protein 3 Pseudogene1 2     F-Box/LRR-Repeat Protein 212
F-Box And Leucine-Rich Repeat Protein 211 3     FBL33
F-Box/LRR-Repeat Protein 3B2 3     

External Ids:    HGNC: 136001   Entrez Gene: 262232   Ensembl: ENSG000001646167   OMIM: 6090875   UniProtKB: Q9UKT63   

Export aliases for FBXL21 gene to outside databases

Previous GC identifers: GC05P135293 GC05P130454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FBXL21 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class and, in addition to an F-box, contains 6 tandem leucine-rich repeats. The
amino acid sequence of this protein is highly similar to that of f-box and leucine-rich repeat protein 3A.
Comparisons of this gene to orthologous sequences suggest that it may be a pseudogene, and may no longer express
a functional protein.(provided by RefSeq, Aug 2009)

GeneCards Summary for FBXL21 Gene:
FBXL21 (F-box and leucine-rich repeat protein 21 (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXL3.

UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6
Function: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian
rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock
oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1
and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the
SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic
nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL21 gene promoter:
         Nkx3-1   COUP-TF1   AML1a   COUP   Nkx2-5   HNF-4alpha2   LCR-F1   HNF-4alpha1   AREB6   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL21 promoter sequence
   Search Chromatin IP Primers for FBXL21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

FBXL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL21 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P135267:  view genomic region     (about GC identifiers)

Start:
135,266,006 bp from pter      End:
135,287,280 bp from pter
Size:
21,275 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 21  
Size: 434 amino acids; 49152 Da
Subunit: Interacts with CRY1 and CRY2 (By similarity). Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein
ligase complex SCF(FBXL21) composed of CUL1, SKP1, RBX1 and FBXL21
Caution: The reference genome sequence codes for a stop codon instead of a Tyr in position 56, suggesting that
this gene may be a pseudogene, at least in some part of the population

Explore the universe of human proteins at neXtProt for FBXL21: NX_Q9UKT6

REFSEQ proteins: NP_036291.2  
ENSEMBL proteins: 
 ENSP00000425963  

FBXL21 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for FBXL21
OriGene Custom MassSpec
OriGene Custom Protein Services for FBXL21
GenScript Custom Purified and Recombinant Proteins Services for FBXL21
Novus Biologicals FBXL21 Proteins
Novus Biologicals FBXL21 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for FBXL21

 
Search eBioscience for Proteins for FBXL21 

 
antibodies-online proteins for FBXL21 (7 products) 

 
Search antibodies-online for peptides for FBXL21

FBXL21 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for FBXL21
Novus Biologicals FBXL21 Antibodies
Abcam antibodies for FBXL21
Cloud-Clone Corp. Antibodies for FBXL21
Search ThermoFisher Antibodies for FBXL21
antibodies-online antibodies for FBXL21 (17 products) 

FBXL21 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for FBXL21
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for FBXL21
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for FBXL21
Cloud-Clone Corp. CLIAs for FBXL21
Search eBioscience for ELISAs for FBXL21 
antibodies-online kits for FBXL21 (31 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
FBXL: F-boxes / Leucine-rich repeats

1 InterPro protein domain:
 IPR001810 F-box_dom

Graphical View of Domain Structure for InterPro Entry Q9UKT6

ProtoNet protein and cluster: Q9UKT6

UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6
Similarity: Contains 1 F-box domain
Similarity: Contains 7 LRR (leucine-rich) repeats


Find genes that share domains with FBXL21           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: FXL21_HUMAN, Q9UKT6
Function: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian
rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock
oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1
and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the
SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic
nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity NAS10531035
     
Find genes that share ontologies with FBXL21           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for FBXL21:
 Decreased cell number 

     1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Fbxl21):
 behavior/neurological 

Find genes that share phenotypes with FBXL21           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for FBXL21

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat FBXL21 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate FBXL21
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for FBXL21
Predesigned siRNA for gene silencing in human, mouse, rat FBXL21

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for FBXL21

Clone
Products:
     
OriGene clones in human, mouse for FBXL21 (see all 7)
OriGene ORF clones in mouse, rat for FBXL21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXL21 (NM_012159)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL21

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for FBXL21
Browse ESI BIO Cell Lines and PureStem Progenitors for FBXL21 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL21


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
FXL21_HUMAN, Q9UKT6: Cytoplasm, cytosol (By similarity). Nucleus (By similarity). Note=Mainly localizes in the
cytosol. Present at low level in the nucleus (By similarity)

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000151ubiquitin ligase complex NAS10531035
GO:0005634nucleus ISS--
GO:0005829cytosol ISS--
GO:0019005SCF ubiquitin ligase complex ISS--

Find genes that share ontologies with FBXL21           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



UniProtKB/Swiss-Prot: FXL21_HUMAN, Q9UKT6
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Array including FBXL21: 

          Circadian Rhythms in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for FBXL21

Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination NAS10531035
GO:0043153entrainment of circadian clock by photoperiod ISS--
GO:0048511rhythmic process IEA--

Find genes that share ontologies with FBXL21           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FBXL21 (FXL21)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for FBXL21 gene: 
NM_012159.4  

Unigene Cluster for FBXL21:

F-box and leucine-rich repeat protein 21 (gene/pseudogene)
Hs.591275  [show with all ESTs]
Unigene Representative Sequence: NM_012159
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000495672 ENST00000475169 ENST00000472159 ENST00000467490(uc003lbc.3)
ENST00000297158(uc021ydv.1 uc021ydw.1) ENST00000478939(uc021ydx.1)
ENST00000498734
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat FBXL21 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate FBXL21
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FBXL21
Predesigned siRNA for gene silencing in human, mouse, rat FBXL21
Clone
Products:
     
OriGene clones in human, mouse for FBXL21 (see all 7)
OriGene ORF clones in mouse, rat for FBXL21
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXL21 (NM_012159)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL21
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL21
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FBXL21
OriGene qSTAR qPCR primer pairs in human, mouse for FBXL21
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXL21
  QuantiTect SYBR Green Assays in human, mouse, rat FBXL21
  QuantiFast Probe-based Assays in human, mouse, rat FBXL21

Additional mRNA sequence: 

AF129533.1 BC106753.2 

3 DOTS entries:

DT.91741594  DT.95142207  DT.95239338 

10 AceView cDNA sequences:

NM_012159 AF129533 AV645509 BC044938 AA700647 AV645740 BI763801 BX093224 
W90022 W88455 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL21    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:                                      -                                       
SP2:                                -     -                                       
SP3:                    -     -     -     -     -                                 
SP4:                                                                              


ECgene alternative splicing isoforms for FBXL21

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

FBXL21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
FBXL21 Expression
About this image


FBXL21 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
 
 NULL (Uncategorized)
         Vascular endothelial growth factor-induced cells
FBXL21 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.591275
    Pathway & Disease-focused RT2 Profiler PCR Array including FBXL21: 
          Circadian Rhythms in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for FBXL21
OriGene qSTAR qPCR primer pairs in human, mouse for FBXL21
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXL21
QuantiTect SYBR Green Assays in human, mouse, rat FBXL21
QuantiFast Probe-based Assays in human, mouse, rat FBXL21
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL21

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for FBXL21 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fbxl211 , 5 F-box and leucine-rich repeat protein 211, 5 80.95(n)1
85.94(a)1
  13 (30.07 cM)5
2133111  NM_178674.41  NP_848789.21 
 565224725 
chicken
(Gallus gallus)
Aves FBXL211 F-box and leucine-rich repeat protein 21 74.38(n)
75(a)
  416306  NM_001270995.1  NP_001257924.1 
lizard
(Anolis carolinensis)
Reptilia FBXL216
F-box and leucine-rich repeat protein 21 (gene/pse...
77(a)
1 ↔ 1
GL343223.1(1376285-1396802)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004893561 F-box/LRR-repeat protein 3-like 72.58(n)
76.27(a)
  100489356  XM_004912774.1  XP_004912831.1 
zebrafish
(Danio rerio)
Actinopterygii fbxl31 F-box and leucine-rich repeat protein 3 69.3(n)
78.37(a)
  564855  XM_688178.2  XP_693270.2 


ENSEMBL Gene Tree for FBXL21 (if available)
TreeFam Gene Tree for FBXL21 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for FBXL21 gene
FBXL32  
1 SIMAP similar gene for FBXL21 using alignment to 2 protein entries:     FXL21_HUMAN (see all proteins):
FBXL3

Find genes that share paralogs with FBXL21           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for FBXL21 (see all 333)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs801384231,2
F--135264049(+) TCTTTG/ATTCGC 1 -- us2k11Minor allele frequency- A:0.16WA 118
rs1905225001,2
--135264052(+) TTGTTC/TGCACA 1 -- us2k10--------
rs1827490901,2
--135264053(+) TGTTCA/GCACAC 1 -- us2k10--------
rs1878242741,2
--135264102(+) TAAATC/TCTAAT 1 -- us2k10--------
rs1144258001,2
C,F--135264132(+) ACTGAC/TAAGTG 1 -- us2k11Minor allele frequency- T:0.19WA 118
rs765621201,2
C,F--135264169(+) ACCAAT/CATAAA 1 -- us2k11Minor allele frequency- C:0.16WA 118
rs760402451,2
C,F--135264195(+) CTTCAT/CACTGG 1 -- us2k11Minor allele frequency- C:0.16WA 118
rs1489333501,2
--135264297(+) ATGTGC/TGTAAG 1 -- us2k10--------
rs1923905011,2
--135264349(+) AAGAAC/GACCTA 1 -- us2k10--------
rs1471072041,2
--135264366(+) TAGAGC/TGCTAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for FBXL21 (135266006 - 135287280 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for FBXL21:    About this table    
Variant IDTypeSubtypePubMed ID
nsv471050CNV Loss18288195
dgv6338n71CNV Loss21882294
dgv1853e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FBXL21
DNA2.0 Custom Variant and Variant Library Synthesis for FBXL21

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 609087    OMIM disorders: --


Find genes that share disorders with FBXL21           About GenesLikeMe

Genetic Association Database (GAD): FBXL21
Human Genome Epidemiology (HuGE) Navigator: FBXL21 (3 documents)

Export disorders for FBXL21 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for FBXL21 gene integrated from 10 sources:
(articles sorted by number of sources associating them with FBXL21)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
  3. FBXL21 association with schizophrenia in Irish family and case-control samples. (PubMed id 18404645)1, 4 Chen X....Kendler K.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
  4. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. (PubMed id 24085301)1 Yumimoto K....Nakayama K.I. (J. Biol. Chem. 2013)
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
  6. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PubMed id 20210993)1 Zhang Z.D....Gerstein M. (Genome Biol. 2010)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 26223 HGNC: 13600 AceView: FBXL21 Ensembl:ENSG00000164616 euGenes: HUgn26223
ECgene: FBXL21 H-InvDB: FBXL21

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for FBXL21 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for FBXL21 gene:
Search GeneIP for patents involving FBXL21

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXL21  
 OriGene qPCR primer pairs and template standards for FBXL21   OriGene Protein Over-expression Lysate for FBXL21  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXL21  
 OriGene qSTAR qPCR primer pairs in human, mouse for FBXL21   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for FBXL21   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for FBXL21   OriGene Custom Protein Services for FBXL21  

 
 
 Block miRNA regulation of human, mouse, rat FBXL21 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FBXL21
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL21 Predesigned siRNA for gene silencing in human, mouse, rat FBXL21
 QuantiFast Probe-based Assays in human, mouse, rat FBXL21 QuantiTect SYBR Green Assays in human, mouse, rat FBXL21
 PCR Arrays including human, mouse, rat FBXL21 Search Chromatin IP Primers for FBXL21
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXL21  Search GeneGlobe Interaction Network for FBXL21
 Regulatory tfbs in FBXL21 promoter
 GenScript Custom Purified and Recombinant Proteins Services for FBXL21 GenScript cDNA clones with any tag delivered in your preferred vector for FBXL21
 GenScript Custom Assay Services for FBXL21 GenScript Custom overexpressing Cell Line Services for FBXL21
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for FBXL21 (FXL21)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 FBXL21 antibodies
 FBXL21 proteins
 FBXL21 lysates
 Antibodies for FBXL21
 See all of Abcam's Antibodies, Kits and Proteins for FBXL21
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for FBXL21
 Antibodies for FBXL21
 ELISAs for FBXL21
 CLIAs for FBXL21



 Browse ESI BIO Cell Lines and PureStem Progenitors for FBXL21
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL21
 Browse SwitchGear 3'UTR luciferase reporter plasmids for FBXL21
 SwitchGear Promoter luciferase reporter plasmids for FBXL21
 Search ThermoFisher Antibodies for FBXL21
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL21
 Browse compounds at ApexBio
 Search Addgene for plasmids for FBXL21
  Search eBioscience for proteins for FBXL21
  Search eBioscience for elisas for FBXL21
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for FBXL21
 antibodies-online antibodies for FBXL21 (17 products)
 antibodies-online kits for FBXL21 (31 products)
  Search antibodies-online for peptides for FBXL21
 antibodies-online proteins for FBXL21 (7 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      FBXL21 gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4