FBXL20 Gene
protein-coding GIFtS: 50
GCID: GC17M037409
|
|
F-box and leucine-rich repeat protein 20
| |
Aliases
for FBXL20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 201 2 3 | | F-Box Protein FBL22 | | Fbl21 2 | | F-Box/LRR-Repeat Protein 202 | | Fbl201 2 | | FBL23 | | MGC154821 | | F-Box/LRR-Repeat Protein 2-Like3 |
Export aliases for FBXL20 gene to outside databasesPrevious GC identifers: GC17M037792 GC17M034670 GC17M037416 GC17M033204 |
Summaries
for FBXL20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL20:
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Rolein neural transmission (By similarity)
|
Genomic Views
for FBXL20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL20 gene promoter:
AP-1 ATF-2 Cdc5 Arnt C/EBPalpha AREB6 SRY STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.2FBXL20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M037409: view genomic region
(about GC identifiers)
Start:
|
37,408,897 bp from pter |
End:
|
37,558,776 bp from pter |
Size:
|
149,880 bases |
Orientation:
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minus strand |
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Proteins
for FBXL20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 20 Size: 436 amino acids; 48423 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: A8K729 Q38J52Alternative splicing: 2 isoforms: Q96IG2-1 Q96IG2-2 Explore the universe of human proteins at neXtProt for FBXL20: NX_Q96IG2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IG2
FBXL20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171835.1 NP_116264.2
ENSEMBL proteins: ENSP00000462271 ENSP00000377832 ENSP00000264658 ENSP00000462878 ENSP00000463132
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
FBXL20 for ontologies About GeneDecksing
FBXL20 Antibody Products:
Assay Products for FBXL20: |
Protein
Domains /
Families
for FBXL20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL20 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96IG2ProtoNet protein and cluster: Q96IG2 UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2Similarity: Contains 1 F-box domainSimilarity: Contains 13 LRR (leucine-rich) repeats |
Function
for FBXL20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Rolein neural transmission (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL20 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL20 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FBXL20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL20 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
FBXL20 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for FBXL20:
Animal Models:
Mouse knock-out Fbxl20tm1Seto for FBXL20
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fbxl20):
FBXL20 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FBXL20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBXL20
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/6 Interacting proteins for FBXL20 (Q96IG23 ENSP000002646584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for FBXL20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL20
Search CenterWatch for drugs/clinical trials and news about FBXL20 / FXL20
|
Transcripts
for FBXL20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL20 gene (2 alternative transcripts): NM_001184906.1 NM_032875.2 Unigene Cluster for FBXL20: F-box and leucine-rich repeat protein 20 Hs.462946 [show with all ESTs]Unigene Representative Sequence: NM_0328755 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583610 ENST00000394294 ENST00000264658(uc002hrt.3 uc010cvu.3)
ENST00000577399 ENST00000581781
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL20 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL20 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FBXL20 (NM_032875) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL20 |
Additional cDNA sequence: AK024690.1 AK123048.1 AK291844.1 AK312612.1 AL117623.1 BC007557.1 BC042012.1 DQ223959.1 19 DOTS entries: DT.87017452 DT.100807858 DT.107887 DT.453917 DT.65285153 DT.100016105 DT.75121748 DT.95351935 DT.435911 DT.97838451 DT.120987184 DT.97772681 DT.40195208 DT.40243904 DT.92034353 DT.100032144 DT.100856937 DT.40300075 DT.95094303 24/44 AceView cDNA sequences (see all 44): BG105188 BX105698 BF433100 BF732482 BQ435996 AA972098 NM_032875 AA825816 BC007557 BU184200 AI122770 AI906026 BM480021 AW294390 BQ436371 AA813428 AA707598 AK123048 BI519367 AW292515 AA745617 BM906344 BF809110 BE292933
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXL20
|
Expression
for FBXL20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCACAAAGA
About this image
See FBXL20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL20
SOURCE GeneReport for Unigene cluster: Hs.462946
SABiosciences Expression via Pathway-Focused PCR Array including FBXL20: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FBXL20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL20 |
Orthologs
for FBXL20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FBXL20 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for FBXL20 (if available)
TreeFam Gene Tree for FBXL20 (if available) |
Paralogs
for FBXL20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXL20 gene
- FBXL172 FBXL22 ENSG000002371022 FBXL132 FBXL162 FBXL72 AMN12 LRRC292
- FBXL152 FBXL42 FBXL142
2 SIMAP similar genes for FBXL20 using alignment to 3 protein entries: FXL20_HUMAN (see all proteins):FBXL2 FBXL7
FBXL20 for paralogs About GeneDecksing
|
Genomic Variants
for FBXL20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL20 (37408897 - 37558776 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for FBXL20
2 CNVs: 102451 5006
2 Indels: 67191 45537 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL20 |
|
Disorders
/ Diseases
for FBXL20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXL20 for disorders About GeneDecksing
OMIM gene information: 609086
OMIM disorders: --
7  diseases for FBXL20: About MalaCardsurinary tract obstruction primary biliary cirrhosis anuria renal vascular disease
vascular disease nephropathy breast cancer
5 diseases from the University of Copenhagen DISEASES database for FBXL20:Kidney failure Proteinuria Nephritis Hypertension
Diabetes mellitus Human Genome Epidemiology (HuGE) Navigator: FBXL20 (1 document)
Export disorders for FBXL20 gene to outside databases
|
Publications
for FBXL20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL20 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FBXL20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1 Mells G.F....Anderson C.A. (2011)
- Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1 Mavaddat N....Pharoah P.D. (2009)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for FBXL20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL20 gene:
Search GeneIP for patents involving FBXL20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL20 |
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