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FBXL20 Gene

protein-coding   GIFtS: 52
GCID: GC17M037409

F-Box And Leucine-Rich Repeat Protein 20

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 201 2 3     F-Box/LRR-Repeat Protein 202
FBL23 5     F-Box/LRR-Repeat Protein 2-Like3
Fbl22     FBL205
Fbl202     SCR5
F-Box Protein FBL22     

External Ids:    HGNC: 246791   Entrez Gene: 849612   Ensembl: ENSG000001083067   OMIM: 6090865   UniProtKB: Q96IG23   

Export aliases for FBXL20 gene to outside databases

Previous GC identifers: GC17M037792 GC17M034670 GC17M037416 GC17M033204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXL20 Gene:
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box
motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as
protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with
ubiquitination targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for FBXL20 Gene:
FBXL20 (F-box and leucine-rich repeat protein 20) is a protein-coding gene. Diseases associated with FBXL20 include renal vascular disease, and anuria. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Role in neural transmission (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL20 gene promoter:
         AP-1   ATF-2   Cdc5   Arnt   C/EBPalpha   AREB6   SRY   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL20 promoter sequence
   Search Chromatin IP Primers for FBXL20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.2

FBXL20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL20 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M037409:  view genomic region     (about GC identifiers)

Start:
37,408,897 bp from pter      End:
37,558,776 bp from pter
Size:
149,880 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 20  
Size: 436 amino acids; 48423 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: A8K729 Q38J52
Alternative splicing: 2 isoforms:  Q96IG2-1   Q96IG2-2   

Explore the universe of human proteins at neXtProt for FBXL20: NX_Q96IG2

Explore proteomics data for FBXL20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXL20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171835.1  NP_116264.2  

    ENSEMBL proteins: 
     ENSP00000462271   ENSP00000377832   ENSP00000264658   ENSP00000462878   ENSP00000463132  

    FBXL20 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for FBXL20
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    Novus Biologicals FBXL20 Proteins
    Novus Biologicals FBXL20 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXL20

    FBXL20 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FBXL20
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    Search for Antibodies for FBXL20 at Abcam
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    LSBio Antibodies in human, mouse, rat for FBXL20

    FBXL20 Assay Products:

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    Cloud-Clone Corp. ELISAs for FBXL20
    Cloud-Clone Corp. CLIAs for FBXL20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXL: F-boxes / Leucine-rich repeats

    2 InterPro protein domains:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q96IG2

    ProtoNet protein and cluster: Q96IG2

    UniProtKB/Swiss-Prot: FXL20_HUMAN, Q96IG2
    Similarity: Contains 1 F-box domain
    Similarity: Contains 13 LRR (leucine-rich) repeats


    FBXL20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FXL20_HUMAN, Q96IG2
    Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
    Role in neural transmission (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    FBXL20 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FBXL20:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fbxl20):
     endocrine/exocrine gland  growth/size/body  mortality/aging  nervous system 

    FBXL20 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fbxl20tm1Seto for FBXL20

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXL20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXL20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXL20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXL20

    miRNA
    Products:
        
    miRTarBase miRNAs that target FBXL20:
    hsa-mir-125b-5p (MIRT046059)

    Block miRNA regulation of human, mouse, rat FBXL20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXL20 (see all 141):
    hsa-miR-128 hsa-miR-605 hsa-miR-3921 hsa-miR-637 hsa-miR-3170 hsa-miR-510 hsa-miR-1266 hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidFBXL20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FBXL20
    Predesigned siRNA for gene silencing in human, mouse, rat FBXL20

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for FBXL20

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXL20 (NM_032875)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL20

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FBXL20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FXL20_HUMAN, Q96IG2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    FBXL20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FBXL20: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FBXL20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXL20 (Q96IG23 ENSP000002646584) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    RIMS1Q86UR53, ENSP000002648394I2D: score=2 STRING: ENSP00000264839
    SKP1P632083, ENSP000002314874I2D: score=2 STRING: ENSP00000231487
    SYPP082473, ENSP000002632334I2D: score=1 STRING: ENSP00000263233
    RAD23BP547273, ENSP000003507084I2D: score=2 STRING: ENSP00000350708
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FBXL20 (FXL20)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXL20 gene (2 alternative transcripts): 
    NM_001184906.1  NM_032875.2  

    Unigene Cluster for FBXL20:

    F-box and leucine-rich repeat protein 20
    Hs.462946  [show with all ESTs]
    Unigene Representative Sequence: NM_032875
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583610 ENST00000394294 ENST00000264658(uc002hrt.3 uc010cvu.3)
    ENST00000577399 ENST00000581781
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FBXL20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXL20 (see all 141):
    hsa-miR-128 hsa-miR-605 hsa-miR-3921 hsa-miR-637 hsa-miR-3170 hsa-miR-510 hsa-miR-1266 hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidFBXL20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FBXL20
    Predesigned siRNA for gene silencing in human, mouse, rat FBXL20
    Clone
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    OriGene clones in human, mouse for FBXL20 (see all 10)
    OriGene ORF clones in mouse, rat for FBXL20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FBXL20 (NM_032875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL20
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXL20
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL20
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FBXL20
      QuantiTect SYBR Green Assays in human, mouse, rat FBXL20
      QuantiFast Probe-based Assays in human, mouse, rat FBXL20

    Additional mRNA sequence: 

    AK024690.1 AK123048.1 AK291844.1 AK312612.1 AL117623.1 BC007557.1 BC042012.1 DQ223959.1 

    19 DOTS entries:

    DT.87017452  DT.100807858  DT.107887  DT.453917  DT.65285153  DT.100016105  DT.75121748  DT.95351935 
    DT.435911  DT.97838451  DT.120987184  DT.97772681  DT.40195208  DT.40243904  DT.92034353  DT.100032144 
    DT.100856937  DT.40300075  DT.95094303 

    Selected AceView cDNA sequences (see all 44):

    AA972098 BC007557 BQ435996 AI906026 AI122770 BF433100 BX105698 BG105188 
    BU184200 AA825816 BF732482 NM_032875 BI519367 AA813428 AW294390 BM906344 
    AW292515 BM480021 AA707598 AK123048 BQ436371 AA745617 BF809110 BE292933 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:                                                                                            -               
    SP2:                                            -                                               -               
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for FBXL20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXL20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACAAAGA
    FBXL20 Expression
    About this image


    FBXL20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Breast (Uncategorized)
    FBXL20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXL20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.462946
        Pathway & Disease-focused RT2 Profiler PCR Array including FBXL20: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat FBXL20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for FBXL20 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl201 , 5 F-box and leucine-rich repeat protein 201, 5 93.12(n)1
    99.77(a)1
      11 (61.69 cM)5
    721941  NM_028149.11  NP_082425.11 
     980825565 
    chicken
    (Gallus gallus)
    Aves FBXL201 F-box and leucine-rich repeat protein 20 82.58(n)
    97.4(a)
      771869  XM_004948580.1  XP_004948637.1 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL206
    F-box and leucine-rich repeat protein 20
    91(a)
    1 ↔ 1
    6(67619713-67716979)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.325292 Xenopus laevis transcribed sequence with moderate similarity more 76.56(n)    CD328092.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxl201 F-box and leucine-rich repeat protein 20 77.52(n)
    92.2(a)
      100331130  XM_002664711.2  XP_002664757.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90031 CG9003 57.05(n)
    58.89(a)
      36244  NM_001273971.1  NP_001260900.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C02F5.71 C02F5.7 51.41(n)
    49.4(a)
      3564805  NM_171210.4  NP_741248.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRR1(YJR090C)4
    GRR11
    F-box protein component of the SCF ubiquitin-ligase more4
    GRR11
    39.19(n)1
    25.81(a)1
      10(594327-590872)4
    8535521, 4  NP_012623.11, 4 


    ENSEMBL Gene Tree for FBXL20 (if available)
    TreeFam Gene Tree for FBXL20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXL20 gene
    FBXL22  FBXL172  ENSG000002371022  FBXL132  FBXL162  FBXL72  LRRC292  FBXL152  
    FBXL142  FBXL42  
    2 SIMAP similar genes for FBXL20 using alignment to 3 protein entries:     FXL20_HUMAN (see all proteins):
    FBXL2    FBXL7

    FBXL20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXL20 (see all 3109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834218621,2
    --37408430(+) ATACTG/TTTATC 2 -- ds50010--------
    rs1415962411,2
    C--37408723(+) TGGCT-/GGGGTTAA 2 -- cds10--------
    rs1381466311,2
    C--37408726(+) CTGTT-/AAAAAA 2 -- ds50010--------
    rs1173972691,2
    C,F--37408742(+) TAAACG/AGAGGT 2 -- ds50011Minor allele frequency- A:0.02NA 120
    rs758047361,2
    C,F--37408841(+) CTCACG/CAGTAG 2 -- ds50011Minor allele frequency- C:0.07NA 120
    rs107175441,2
    C--37409021(+) tttttT/-AGTCC 2 -- ut312Minor allele frequency- -:0.25NA 4
    rs747326471,2
    C,F--37409069(+) AATCCT/CCTACT 2 -- ut311Minor allele frequency- C:0.01EA 120
    rs1860137051,2
    --37409203(+) AACTGC/TGTCGG 2 -- ut310--------
    rs1412366741,2
    --37409275(+) TCACAC/TACTGC 2 -- ut310--------
    rs1449479981,2
    --37409505(+) CTCTGA/CGCTCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for FBXL20 (37408897 - 37558776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FBXL20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671262CNV Deletion23128226
    esv2506125CNV Deletion19546169
    esv2715900CNV Deletion23290073
    esv2132100CNV Deletion18987734
    esv2661698CNV Deletion23128226
    esv24997CNV Loss19812545
    nsv833441CNV Loss17160897
    nsv510709CNV Loss20534489
    nsv908204CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXL20
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609086    OMIM disorders: --

    12 diseases for FBXL20:    
    About MalaCards
    renal vascular disease    anuria    urinary tract obstruction    vascular disease
    primary biliary cirrhosis    proteinuria    nephritis    diabetes mellitus
    hypertension    adenocarcinoma    breast cancer    malaria

    5 diseases from the University of Copenhagen DISEASES database for FBXL20:
    Kidney failure     Proteinuria     Nephritis     Hypertension
    Diabetes mellitus

    FBXL20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXL20
    Human Genome Epidemiology (HuGE) Navigator: FBXL20 (1 document)

    Export disorders for FBXL20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXL20 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with FBXL20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PubMed id 21399635)1, 4 Mells G.F....Anderson C.A. (Nat. Genet. 2011)
    2. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Role of FBXL20 in human colorectal adenocarcinoma. (PubMed id 23023584)1 Zhu J....Chen Y. (Oncol. Rep. 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84961 HGNC: 24679 AceView: FBXL20 Ensembl:ENSG00000108306 euGenes: HUgn84961
    ECgene: FBXL20 H-InvDB: FBXL20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FBXL20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FBXL20 gene:
    Search GeneIP for patents involving FBXL20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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