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Aliases for FBXL20 Gene

Aliases for FBXL20 Gene

  • F-Box And Leucine-Rich Repeat Protein 20 2 3 4 5
  • FBL2 3 4
  • F-Box/LRR-Repeat Protein 2-Like 4
  • F-Box Protein FBL2 3
  • Fbl20 3

External Ids for FBXL20 Gene

Previous GeneCards Identifiers for FBXL20 Gene

  • GC17M037792
  • GC17M034670
  • GC17M037416
  • GC17M033204
  • GC17M037409

Summaries for FBXL20 Gene

Entrez Gene Summary for FBXL20 Gene

  • Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL20 Gene

FBXL20 (F-Box And Leucine-Rich Repeat Protein 20) is a Protein Coding gene. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL20 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL20 Gene

Genomics for FBXL20 Gene

Regulatory Elements for FBXL20 Gene

Enhancers for FBXL20 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXL20 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL20 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL20 Gene

39,252,644 bp from pter
39,402,661 bp from pter
150,018 bases
Minus strand

Genomic View for FBXL20 Gene

Genes around FBXL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL20 Gene

Proteins for FBXL20 Gene

  • Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 20
    Protein Accession:
    Secondary Accessions:
    • A8K729
    • Q38J52

    Protein attributes for FBXL20 Gene

    436 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL20 Gene


neXtProt entry for FBXL20 Gene

Proteomics data for FBXL20 Gene at MOPED

Post-translational modifications for FBXL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL20 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXL20

No data available for DME Specific Peptides for FBXL20 Gene

Domains & Families for FBXL20 Gene

Gene Families for FBXL20 Gene

Protein Domains for FBXL20 Gene

Suggested Antigen Peptide Sequences for FBXL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 13 LRR (leucine-rich) repeats.
  • Contains 1 F-box domain.
  • Contains 13 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL20: view

Function for FBXL20 Gene

Molecular function for FBXL20 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
genes like me logo Genes that share phenotypes with FBXL20: view

Animal Models for FBXL20 Gene

MGI Knock Outs for FBXL20:

Animal Model Products

CRISPR Products

miRNA for FBXL20 Gene

miRTarBase miRNAs that target FBXL20

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL20 Gene

Localization for FBXL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene


Subcellular locations from

Jensen Localization Image for FBXL20 Gene COMPARTMENTS Subcellular localization image for FBXL20 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FBXL20 Gene

Pathways & Interactions for FBXL20 Gene

SuperPathways for FBXL20 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL20 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXL20 Gene

Drugs & Compounds for FBXL20 Gene

No Compound Related Data Available

Transcripts for FBXL20 Gene

Unigene Clusters for FBXL20 Gene

F-box and leucine-rich repeat protein 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2: - -

Relevant External Links for FBXL20 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL20 Gene

mRNA expression in normal human tissues for FBXL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Testis (7.8), Fetal Brain (7.8), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL20 Gene

SOURCE GeneReport for Unigene cluster for FBXL20 Gene Hs.462946

genes like me logo Genes that share expression patterns with FBXL20: view

Protein tissue co-expression partners for FBXL20 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL20 Gene

Orthologs for FBXL20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL20 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXL20 35
  • 95.97 (n)
  • 100 (a)
FBXL20 36
  • 100 (a)
(Canis familiaris)
Mammalia FBXL20 35
  • 96.41 (n)
  • 100 (a)
FBXL20 36
  • 100 (a)
(Mus musculus)
Mammalia Fbxl20 35
  • 93.12 (n)
  • 99.77 (a)
Fbxl20 16
Fbxl20 36
  • 100 (a)
(Pan troglodytes)
Mammalia FBXL20 35
  • 99.92 (n)
  • 100 (a)
FBXL20 36
  • 100 (a)
(Monodelphis domestica)
Mammalia FBXL20 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL20 36
  • 99 (a)
(Gallus gallus)
Aves FBXL20 35
  • 82.58 (n)
  • 97.4 (a)
FBXL20 36
  • 85 (a)
(Anolis carolinensis)
Reptilia FBXL20 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl20 35
  • 77.91 (n)
  • 93.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32529 35
(Danio rerio)
Actinopterygii fbxl20 35
  • 77.52 (n)
  • 92.2 (a)
fbxl20 36
  • 92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007807 35
  • 57.79 (n)
  • 59.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9003 35
  • 57.05 (n)
  • 58.89 (a)
CG9003 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea C02F5.7 35
  • 51.41 (n)
  • 49.4 (a)
C02F5.7 36
  • 45 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER398W 35
  • 37.4 (n)
  • 26.88 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06051g 35
  • 40.98 (n)
  • 26.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 35
  • 39.19 (n)
  • 25.81 (a)
GRR1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2004 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01216 35
  • 41.07 (n)
  • 29.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pof2 35
  • 41.01 (n)
  • 29.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for FBXL20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXL20 Gene

Gene Tree for FBXL20 (if available)
Gene Tree for FBXL20 (if available)

Paralogs for FBXL20 Gene

Paralogs for FBXL20 Gene

(2) SIMAP similar genes for FBXL20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL20: view

Variants for FBXL20 Gene

Sequence variations from dbSNP and Humsavar for FBXL20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs582088 -- 39,297,796(-) atcac(A/G)ccact intron-variant
rs582176 -- 39,297,746(-) aagaa(A/G)aaTCA intron-variant
rs583980 -- 39,292,918(-) ctact(C/T)aggag intron-variant
rs584377 -- 39,303,875(-) AACCC(C/T)GTTTC intron-variant
rs585961 -- 39,287,783(-) cagtt(C/T)tcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL20 Gene

Variant ID Type Subtype PubMed ID
nsv833441 CNV Loss 17160897
nsv908204 CNV Gain 21882294
nsv510709 CNV Loss 20534489
esv2506125 CNV Deletion 19546169
esv2132100 CNV Deletion 18987734
esv2661698 CNV Deletion 23128226
esv2715900 CNV Deletion 23290073
esv24997 CNV Loss 19812545
esv2671262 CNV Deletion 23128226

Variation tolerance for FBXL20 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXL20 Gene

Disorders for FBXL20 Gene

Relevant External Links for FBXL20

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL20 Gene

Publications for FBXL20 Gene

  1. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. (PMID: 25593308) Xiao J. … Yuan J. (Genes Dev. 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Role of FBXL20 in human colorectal adenocarcinoma. (PMID: 23023584) Zhu J. … Chen Y. (Oncol. Rep. 2012) 3

Products for FBXL20 Gene

Sources for FBXL20 Gene