Aliases for FBXL20 Gene
Aliases for FBXL20 Gene
External Ids for FBXL20 Gene
- HGNC: 24679
- Entrez Gene: 84961
- Ensembl: ENSG00000108306
- OMIM: 609086
- UniProtKB: Q96IG2
Previous GeneCards Identifiers for FBXL20 Gene
- GC17M037792
- GC17M034670
- GC17M037416
- GC17M033204
- GC17M037409
Summaries for FBXL20 Gene
-
Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXL20 Gene
FBXL20 (F-Box And Leucine Rich Repeat Protein 20) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL2.
UniProtKB/Swiss-Prot for FBXL20 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL20 Gene
Genomics for FBXL20 Gene
Regulatory Elements for FBXL20 Gene
- Transcription factor binding sites by QIAGEN in the FBXL20 gene promoter:
Regulatory Element Products
Genomic Location for FBXL20 Gene
- Chromosome:
- 17
- Start:
- 39,252,644 bp from pter
- End:
- 39,402,661 bp from pter
- Size:
- 150,018 bases
- Orientation:
- Minus strand
Genomic View for FBXL20 Gene
- Cytogenetic band:
-
- 17q12 by Ensembl
- 17q12 by Entrez Gene
- 17q12 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL20 Gene
Proteins for FBXL20 Gene
-
Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96IG2-FXL20_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 20
- Protein Accession:
- Q96IG2
- A8K729
- Q38J52
Protein attributes for FBXL20 Gene
- Size:
- 436 amino acids
- Molecular mass:
- 48423 Da
- Quaternary structure:
-
- Interacts with SKP1 and CUL1.
Protein Expression for FBXL20 Gene
Post-translational modifications for FBXL20 Gene
Other Protein References for FBXL20 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FBXL20
- Novus Biologicals Antibodies for FBXL20
- Invitrogen Antibodies for FBXL20
- antibodies-online Antibodies for FBXL20: See all 43
- GeneTex FBXL20 antibody for FBXL20
-
Custom Antibody ServicesProSci Antibodies for FBXL20
-
Santa Cruz Biotechnology (SCBT) Antibodies for FBXL20
Protein Products
-
OriGene Purified Proteins for FBXL20
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL20
- Origene Custom Protein Services for FBXL20
- antibodies-online Proteins for FBXL20: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL20
Assay Products
- antibodies-online Kits for FBXL20: See all 21
No data available for DME Specific Peptides for FBXL20 Gene
Domains & Families for FBXL20 Gene
Gene Families for FBXL20 Gene
Protein Domains for FBXL20 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL20 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL20 Gene
Function for FBXL20 Gene
Molecular function for FBXL20 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 27705803 |
Phenotypes for FBXL20 Gene
- MGI mutant phenotypes for FBXL20:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXL20:
Animal Models for FBXL20 Gene
- MGI Knock Outs for FBXL20:
-
- Fbxl20 tm1Seto
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL20 gene
-
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- Search ViGene Biosciences for FBXL20
CRISPR Products
-
OriGene CRISPR knockouts for FBXL20
-
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- GenScript: Design CRISPR guide RNA sequences for FBXL20
miRNA for FBXL20 Gene
- miRTarBase miRNAs that target FBXL20
-
- hsa-mir-125b-5p (MIRT046059)
- hsa-mir-7703 (MIRT076968)
- hsa-mir-767-3p (MIRT196905)
- hsa-mir-1178-3p (MIRT196906)
- hsa-mir-181b-3p (MIRT196920)
- hsa-mir-181b-2-3p (MIRT196921)
- hsa-mir-4420 (MIRT196933)
- hsa-mir-6760-3p (MIRT196936)
- hsa-mir-4768-5p (MIRT234310)
- hsa-mir-6817-3p (MIRT234311)
- hsa-mir-6833-3p (MIRT234312)
- hsa-mir-6873-3p (MIRT234313)
- hsa-mir-7110-3p (MIRT234314)
- hsa-mir-6818-5p (MIRT548257)
- hsa-mir-202-3p (MIRT548258)
- hsa-mir-98-5p (MIRT548259)
- hsa-mir-4500 (MIRT548260)
- hsa-mir-4458 (MIRT548261)
- hsa-let-7i-5p (MIRT548262)
- hsa-let-7g-5p (MIRT548263)
- hsa-let-7e-5p (MIRT548264)
- hsa-let-7f-5p (MIRT548265)
- hsa-let-7d-5p (MIRT548266)
- hsa-let-7c-5p (MIRT548267)
- hsa-let-7b-5p (MIRT548268)
- hsa-mir-4468 (MIRT548269)
- hsa-let-7a-5p (MIRT548270)
- hsa-mir-3908 (MIRT548271)
- hsa-mir-511-3p (MIRT548272)
- hsa-mir-424-5p (MIRT548273)
- hsa-mir-15b-5p (MIRT548274)
- hsa-mir-15a-5p (MIRT548275)
- hsa-mir-16-5p (MIRT548276)
- hsa-mir-195-5p (MIRT548277)
- hsa-mir-497-5p (MIRT548278)
- hsa-mir-6838-5p (MIRT548279)
- hsa-mir-26b-3p (MIRT628224)
- hsa-mir-6793-3p (MIRT628225)
- hsa-mir-1208 (MIRT628226)
- hsa-mir-4762-5p (MIRT628227)
- hsa-mir-216b-5p (MIRT628228)
- hsa-mir-378g (MIRT635254)
- hsa-mir-4486 (MIRT635255)
- hsa-mir-6860 (MIRT635256)
- hsa-mir-612 (MIRT635257)
- hsa-mir-5189-5p (MIRT635258)
- hsa-mir-3187-5p (MIRT635259)
- hsa-mir-1285-3p (MIRT635260)
- hsa-mir-4793-3p (MIRT635261)
- hsa-mir-3925-3p (MIRT635262)
- hsa-mir-1273g-3p (MIRT635263)
- hsa-mir-622 (MIRT635264)
- hsa-mir-508-5p (MIRT635265)
- hsa-mir-586 (MIRT658216)
- hsa-mir-6805-3p (MIRT709407)
- hsa-mir-5691 (MIRT709408)
- hsa-mir-3678-3p (MIRT709409)
- hsa-mir-3194-3p (MIRT709410)
- hsa-mir-2467-3p (MIRT709411)
- hsa-mir-17-3p (MIRT709412)
- hsa-mir-1205 (MIRT709413)
- hsa-mir-1184 (MIRT709414)
- hsa-mir-3158-5p (MIRT709415)
- hsa-mir-4684-5p (MIRT709416)
- hsa-mir-7975 (MIRT709417)
- hsa-mir-4540 (MIRT709418)
- hsa-mir-942-5p (MIRT709419)
- hsa-mir-1251-5p (MIRT709420)
- hsa-mir-517-5p (MIRT709421)
- hsa-mir-554 (MIRT709422)
- hsa-mir-6838-3p (MIRT709423)
- hsa-mir-624-5p (MIRT709424)
miRNA Products
- Search ViGene Biosciences for FBXL20
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXL20
- Browse OriGene Inhibitory RNA Products For FBXL20
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL20 gene
Cell Line Products
-
Horizon Cell Lines for FBXL20
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL20 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL20 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL20 Gene
Localization for FBXL20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene
- Cytoplasm.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FBXL20 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL20 Gene
4 Reactome pathways for FBXL20 Gene
Interacting Proteins for FBXL20 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0001662 | behavioral fear response | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL20 Gene
Transcripts for FBXL20 Gene
mRNA/cDNA for FBXL20 Gene
- (4) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (44) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL20 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL20
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL20
- GenScript: Design CRISPR guide RNA sequences for FBXL20
miRNA Products
- Search ViGene Biosciences for FBXL20
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXL20
- Browse OriGene Inhibitory RNA Products For FBXL20
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL20 gene
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Expression for FBXL20 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL20 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL20 Gene:
FBXL20SOURCE GeneReport for Unigene cluster for FBXL20 Gene:
Hs.462946Evidence on tissue expression from TISSUES for FBXL20 Gene
- Intestine(4.2)
- Liver(4.2)
- Blood(4.1)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXL20
-
OriGene qPCR primer pairs for FBXL20
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL20 Gene
Orthologs for FBXL20 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL20 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXL20 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL20 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXL20 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL20 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl20 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | FBXL20 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL20 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl20 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.32529 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxl20 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007807 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9003 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C02F5.7 34 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E06051g 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GRR1 34 37 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER398W 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01216 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | pof2 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2004 34 |
|
- Species where no ortholog for FBXL20 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FBXL20 Gene
Variants for FBXL20 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002468 | -- | 39,326,608(+) | CAGAG(A/C/G)AAGAC | intron-variant | |
| rs1000062449 | -- | 39,277,906(+) | TATCA(C/T)GCTGT | intron-variant | |
| rs1000069776 | -- | 39,397,325(+) | AAAAA(C/G)AATAA | intron-variant | |
| rs1000079000 | -- | 39,284,868(+) | CTTAA(A/C)GTACC | intron-variant | |
| rs1000086825 | -- | 39,402,467(+) | AGCTG(C/G)ACCTG | upstream-variant-2KB, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2132100 | CNV | deletion | 18987734 |
| esv24997 | CNV | loss | 19812545 |
| esv2506125 | CNV | deletion | 19546169 |
| esv2661698 | CNV | deletion | 23128226 |
| esv2671262 | CNV | deletion | 23128226 |
| esv2715900 | CNV | deletion | 23290073 |
| esv3157123 | CNV | deletion | 24192839 |
| esv3554401 | CNV | deletion | 23714750 |
| esv3640544 | CNV | loss | 21293372 |
| nsv1055612 | CNV | gain | 25217958 |
| nsv1072734 | CNV | deletion | 25765185 |
| nsv1109073 | CNV | deletion | 24896259 |
| nsv1138537 | CNV | deletion | 24896259 |
| nsv1138538 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv510709 | CNV | deletion | 20534489 |
| nsv833441 | CNV | loss | 17160897 |
| nsv955409 | CNV | deletion | 24416366 |
Relevant External Links for FBXL20 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL20 Gene
Disorders for FBXL20 Gene
Relevant External Links for FBXL20
No disorders were found for FBXL20 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL20 Gene
Publications for FBXL20 Gene
- Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 46 64
- Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N. … Pharoah P.D. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
Products for FBXL20 Gene
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- Novus Biologicals Antibodies for FBXL20
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- antibodies-online Antibodies for FBXL20: See all 43
- antibodies-online Kits for FBXL20: See all 21
- antibodies-online Proteins for FBXL20: See all 6
- Search antibodies-online for peptides
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL20 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
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