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Aliases for FBXL20 Gene

Aliases for FBXL20 Gene

  • F-Box And Leucine Rich Repeat Protein 20 2 3 5
  • FBL2 3 4
  • F-Box And Leucine-Rich Repeat Protein 20 4
  • F-Box/LRR-Repeat Protein 2-Like 4
  • F-Box/LRR-Repeat Protein 20 3
  • F-Box Protein FBL2 3
  • Fbl20 3

External Ids for FBXL20 Gene

Previous GeneCards Identifiers for FBXL20 Gene

  • GC17M037792
  • GC17M034670
  • GC17M037416
  • GC17M033204
  • GC17M037409

Summaries for FBXL20 Gene

Entrez Gene Summary for FBXL20 Gene

  • Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL20 Gene

FBXL20 (F-Box And Leucine Rich Repeat Protein 20) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot for FBXL20 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL20 Gene

Genomics for FBXL20 Gene

Regulatory Elements for FBXL20 Gene

Enhancers for FBXL20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G039753 2 FANTOM5 Ensembl ENCODE dbSUPER 3.4 -353.9 -353934 7.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF766 ZNF143 GSDMB ORMDL3 THRA IKZF3 KRT222 MED24 STARD3 FBXL20 CDK12 WIPF2
GH17G039766 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -372.2 -372227 17.2 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A FEZF1 ZNF2 CBX5 FOS SP3 GSDMB ENSG00000266469 MED1 ORMDL3 GSDMA CDK12 ERBB2 MIEN1 GRB7 SNORA21
GH17G039812 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -411.1 -411064 2.7 PKNOX1 ZBTB21 ZNF10 FEZF1 ZBTB8A ZIC2 ZNF843 YY1 ZNF121 GATA3 ORMDL3 GSDMB PGAP3 ERBB2 GSDMA IKZF3 FBXL20 CASC3 WIPF2 CDK12
GH17G039658 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 1.7 -261.0 -261030 10.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PGAP3 MED1 ENSG00000266469 LOC100287808 STAC2 CDK12 MSL1 FBXL20 TCAP STARD3
GH17G039817 1.4 FANTOM5 ENCODE dbSUPER 1.9 -417.5 -417533 4.8 CTCF TAL1 BACH1 RELA ZNF121 ARID3A EED RELB IKZF2 CREM GSDMB IKZF3 GSDMA PGAP3 FBXL20 WIPF2 ORMDL3 CASC3 GC17P039815 KRT8P34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL20 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093927 961 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 FOS

Genomic Location for FBXL20 Gene

Chromosome:
17
Start:
39,252,644 bp from pter
End:
39,402,661 bp from pter
Size:
150,018 bases
Orientation:
Minus strand

Genomic View for FBXL20 Gene

Genes around FBXL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL20 Gene

Proteins for FBXL20 Gene

  • Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IG2-FXL20_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 20
    Protein Accession:
    Q96IG2
    Secondary Accessions:
    • A8K729
    • Q38J52

    Protein attributes for FBXL20 Gene

    Size:
    436 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL20 Gene

Post-translational modifications for FBXL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL20 Gene

No data available for DME Specific Peptides for FBXL20 Gene

Domains & Families for FBXL20 Gene

Gene Families for FBXL20 Gene

Protein Domains for FBXL20 Gene

Suggested Antigen Peptide Sequences for FBXL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL20: view

No data available for UniProtKB/Swiss-Prot for FBXL20 Gene

Function for FBXL20 Gene

Molecular function for FBXL20 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

Gene Ontology (GO) - Molecular Function for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 27705803
genes like me logo Genes that share ontologies with FBXL20: view
genes like me logo Genes that share phenotypes with FBXL20: view

Animal Models for FBXL20 Gene

MGI Knock Outs for FBXL20:

Animal Model Products

CRISPR Products

miRNA for FBXL20 Gene

miRTarBase miRNAs that target FBXL20

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL20 Gene

Localization for FBXL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL20 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL20: view

Pathways & Interactions for FBXL20 Gene

genes like me logo Genes that share pathways with FBXL20: view

Gene Ontology (GO) - Biological Process for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0001662 behavioral fear response IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL20: view

No data available for SIGNOR curated interactions for FBXL20 Gene

Drugs & Compounds for FBXL20 Gene

No Compound Related Data Available

Transcripts for FBXL20 Gene

Unigene Clusters for FBXL20 Gene

F-box and leucine-rich repeat protein 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2: - -
SP3:

Relevant External Links for FBXL20 Gene

GeneLoc Exon Structure for
FBXL20
ECgene alternative splicing isoforms for
FBXL20

Expression for FBXL20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Testis (7.8), Fetal Brain (7.8), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL20 Gene



Protein tissue co-expression partners for FBXL20 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL20 Gene:

FBXL20

SOURCE GeneReport for Unigene cluster for FBXL20 Gene:

Hs.462946

Evidence on tissue expression from TISSUES for FBXL20 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FBXL20: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL20 Gene

Orthologs for FBXL20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL20 34 35
  • 99.92 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL20 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL20 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL20 34 35
  • 96.41 (n)
cow
(Bos Taurus)
Mammalia FBXL20 34 35
  • 95.97 (n)
mouse
(Mus musculus)
Mammalia Fbxl20 34 16 35
  • 93.12 (n)
chicken
(Gallus gallus)
Aves FBXL20 34 35
  • 82.58 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL20 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl20 34
  • 77.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32529 34
zebrafish
(Danio rerio)
Actinopterygii fbxl20 34 35
  • 77.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007807 34
  • 57.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9003 34 35
  • 57.05 (n)
worm
(Caenorhabditis elegans)
Secernentea C02F5.7 34 35
  • 51.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06051g 34
  • 40.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 34 37
  • 39.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER398W 34
  • 37.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01216 34
  • 41.07 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pof2 34
  • 41.01 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2004 34
Species where no ortholog for FBXL20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXL20 Gene

ENSEMBL:
Gene Tree for FBXL20 (if available)
TreeFam:
Gene Tree for FBXL20 (if available)

Paralogs for FBXL20 Gene

Paralogs for FBXL20 Gene

(2) SIMAP similar genes for FBXL20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL20: view

Variants for FBXL20 Gene

Sequence variations from dbSNP and Humsavar for FBXL20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000002468 -- 39,326,608(+) CAGAG(A/C/G)AAGAC intron-variant
rs1000062449 -- 39,277,906(+) TATCA(C/T)GCTGT intron-variant
rs1000069776 -- 39,397,325(+) AAAAA(C/G)AATAA intron-variant
rs1000079000 -- 39,284,868(+) CTTAA(A/C)GTACC intron-variant
rs1000086825 -- 39,402,467(+) AGCTG(C/G)ACCTG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXL20 Gene

Variant ID Type Subtype PubMed ID
esv2132100 CNV deletion 18987734
esv24997 CNV loss 19812545
esv2506125 CNV deletion 19546169
esv2661698 CNV deletion 23128226
esv2671262 CNV deletion 23128226
esv2715900 CNV deletion 23290073
esv3157123 CNV deletion 24192839
esv3554401 CNV deletion 23714750
esv3640544 CNV loss 21293372
nsv1055612 CNV gain 25217958
nsv1072734 CNV deletion 25765185
nsv1109073 CNV deletion 24896259
nsv1138537 CNV deletion 24896259
nsv1138538 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv510709 CNV deletion 20534489
nsv833441 CNV loss 17160897
nsv955409 CNV deletion 24416366

Variation tolerance for FBXL20 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL20 Gene

Human Gene Mutation Database (HGMD)
FBXL20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL20 Gene

Disorders for FBXL20 Gene

Relevant External Links for FBXL20

Genetic Association Database (GAD)
FBXL20
Human Genome Epidemiology (HuGE) Navigator
FBXL20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL20

No disorders were found for FBXL20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL20 Gene

Publications for FBXL20 Gene

  1. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 46 64
  2. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N. … Pharoah P.D. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64

Products for FBXL20 Gene

Sources for FBXL20 Gene

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