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Aliases for FBXL20 Gene

Aliases for FBXL20 Gene

  • F-Box And Leucine-Rich Repeat Protein 20 2 3 4
  • FBL2 3 4 6
  • Fbl20 3 6
  • F-Box/LRR-Repeat Protein 2-Like 4
  • F-Box/LRR-Repeat Protein 20 3
  • F-Box Protein FBL2 3
  • SCR 6

External Ids for FBXL20 Gene

Previous GeneCards Identifiers for FBXL20 Gene

  • GC17M037792
  • GC17M034670
  • GC17M037416
  • GC17M033204
  • GC17M037409

Summaries for FBXL20 Gene

Entrez Gene Summary for FBXL20 Gene

  • Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL20 Gene

FBXL20 (F-Box And Leucine-Rich Repeat Protein 20) is a Protein Coding gene. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL20 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL20 Gene

Genomics for FBXL20 Gene

Regulatory Elements for FBXL20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL20 Gene

Start:
39,252,644 bp from pter
End:
39,402,523 bp from pter
Size:
149,880 bases
Orientation:
Minus strand

Genomic View for FBXL20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL20 Gene

Proteins for FBXL20 Gene

  • Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IG2-FXL20_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 20
    Protein Accession:
    Q96IG2
    Secondary Accessions:
    • A8K729
    • Q38J52

    Protein attributes for FBXL20 Gene

    Size:
    436 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL20 Gene

Proteomics data for FBXL20 Gene at MOPED

Post-translational modifications for FBXL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL20 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FBXL20

No data available for DME Specific Peptides for FBXL20 Gene

Domains for FBXL20 Gene

Gene Families for FBXL20 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL20 Gene

Suggested Antigen Peptide Sequences for FBXL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96IG2

UniProtKB/Swiss-Prot:

FXL20_HUMAN :
  • Q96IG2
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 13 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL20: view

Function for FBXL20 Gene

Molecular function for FBXL20 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

Gene Ontology (GO) - Molecular Function for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL20: view
genes like me logo Genes that share phenotypes with FBXL20: view

Animal Models for FBXL20 Gene

MGI Knock Outs for FBXL20:

Animal Model Products

CRISPR Products

miRNA for FBXL20 Gene

miRTarBase miRNAs that target FBXL20

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL20

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FBXL20 Gene

Localization for FBXL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL20 Gene COMPARTMENTS Subcellular localization image for FBXL20 gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FBXL20: view

Pathways for FBXL20 Gene

SuperPathways for FBXL20 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat

Gene Ontology (GO) - Biological Process for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
genes like me logo Genes that share ontologies with FBXL20: view

No data available for Pathways by source for FBXL20 Gene

Transcripts for FBXL20 Gene

Unigene Clusters for FBXL20 Gene

F-box and leucine-rich repeat protein 20:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL20

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2: - -
SP3:

Relevant External Links for FBXL20 Gene

GeneLoc Exon Structure for
FBXL20
ECgene alternative splicing isoforms for
FBXL20

Expression for FBXL20 Gene

mRNA expression in normal human tissues for FBXL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FBXL20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Testis (7.8), Fetal Brain (7.8), and Placenta (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL20 Gene

SOURCE GeneReport for Unigene cluster for FBXL20 Gene Hs.462946

genes like me logo Genes that share expressions with FBXL20: view

Expression partners for FBXL20 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL20 Gene

Orthologs for FBXL20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXL20 35
  • 95.97 (n)
  • 100 (a)
FBXL20 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL20 35
  • 96.41 (n)
  • 100 (a)
FBXL20 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl20 35
  • 93.12 (n)
  • 99.77 (a)
Fbxl20 16
Fbxl20 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL20 35
  • 99.92 (n)
  • 100 (a)
FBXL20 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL20 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL20 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL20 35
  • 82.58 (n)
  • 97.4 (a)
FBXL20 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL20 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl20 35
  • 77.91 (n)
  • 93.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32529 35
zebrafish
(Danio rerio)
Actinopterygii fbxl20 35
  • 77.52 (n)
  • 92.2 (a)
fbxl20 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007807 35
  • 57.79 (n)
  • 59.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9003 35
  • 57.05 (n)
  • 58.89 (a)
CG9003 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C02F5.7 35
  • 51.41 (n)
  • 49.4 (a)
C02F5.7 36
  • 45 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER398W 35
  • 37.4 (n)
  • 26.88 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06051g 35
  • 40.98 (n)
  • 26.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 35
  • 39.19 (n)
  • 25.81 (a)
GRR1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2004 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01216 35
  • 41.07 (n)
  • 29.08 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pof2 35
  • 41.01 (n)
  • 29.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for FBXL20:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXL20 Gene

ENSEMBL:
Gene Tree for FBXL20 (if available)
TreeFam:
Gene Tree for FBXL20 (if available)

Paralogs for FBXL20 Gene

Paralogs for FBXL20 Gene

Selected SIMAP similar genes for FBXL20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL20: view

Variants for FBXL20 Gene

Sequence variations from dbSNP and Humsavar for FBXL20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs582088 -- 39,297,796(-) atcac(A/G)ccact intron-variant
rs582176 -- 39,297,746(-) aagaa(A/G)aaTCA intron-variant
rs583980 -- 39,292,918(-) ctact(C/T)aggag intron-variant
rs584377 -- 39,303,875(-) AACCC(C/T)GTTTC intron-variant
rs585961 -- 39,287,783(-) cagtt(C/T)tcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL20 Gene

Variant ID Type Subtype PubMed ID
nsv833441 CNV Loss 17160897
nsv908204 CNV Gain 21882294
nsv510709 CNV Loss 20534489
esv2506125 CNV Deletion 19546169
esv2132100 CNV Deletion 18987734
esv2661698 CNV Deletion 23128226
esv2715900 CNV Deletion 23290073
esv24997 CNV Loss 19812545
esv2671262 CNV Deletion 23128226

Relevant External Links for FBXL20 Gene

HapMap Linkage Disequilibrium report
FBXL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL20 Gene

Disorders for FBXL20 Gene

(5) University of Copenhagen DISEASES for FBXL20 Gene

Relevant External Links for FBXL20

Genetic Association Database (GAD)
FBXL20
Human Genome Epidemiology (HuGE) Navigator
FBXL20
genes like me logo Genes that share disorders with FBXL20: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for FBXL20 Gene

Publications for FBXL20 Gene

  1. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N. … Pharoah P.D. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 48
  2. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells G.F. … Anderson C.A. (Nat. Genet. 2011) 3 48
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3

Products for FBXL20 Gene

Sources for FBXL20 Gene

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