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Aliases for FBXL20 Gene

Aliases for FBXL20 Gene

  • F-Box And Leucine Rich Repeat Protein 20 2 3 5
  • FBL2 3 4
  • F-Box And Leucine-Rich Repeat Protein 20 4
  • F-Box/LRR-Repeat Protein 2-Like 4
  • F-Box/LRR-Repeat Protein 20 3
  • F-Box Protein FBL2 3
  • Fbl20 3

External Ids for FBXL20 Gene

Previous GeneCards Identifiers for FBXL20 Gene

  • GC17M037792
  • GC17M034670
  • GC17M037416
  • GC17M033204
  • GC17M037409

Summaries for FBXL20 Gene

Entrez Gene Summary for FBXL20 Gene

  • Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL20 Gene

FBXL20 (F-Box And Leucine Rich Repeat Protein 20) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot for FBXL20 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

Additional gene information for FBXL20 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL20 Gene

Genomics for FBXL20 Gene

Regulatory Elements for FBXL20 Gene

Enhancers for FBXL20 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H039658 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10 -261.0 -261030 10 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 PGAP3 MSL1 STARD3 MED24 MED1 CDK12 LOC105371762 STAC2 FBXL20 TCAP
GH17H038414 2 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +987.2 987169 2 PKNOX1 ARNT ARID4B FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF143 FOS LOC105371762 LINC02079 GPR179 RPL19 FBXL20 EPOP GC17M038417 PIR32801 GC17M038418 GC17P038485
GH17H038745 1.5 ENCODE dbSUPER 10 +652.9 652888 8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A MED1 CDK12 LOC105371762 SNORA21 PCGF2 LOC105371763 CISD3 STARD3 RPL19 RPL23
GH17H038724 1.4 ENCODE dbSUPER 9.7 +673.2 673199 10 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 PCGF2 MED1 CDK12 RPL23 LOC105371762 MLLT6 LINC02079 PGAP3 STARD3 PSMB3
GH17H040138 1.2 ENCODE 9.7 -737.7 -737678 3 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 STARD3 IGFBP4 RPL19 THRA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL20 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093927 961 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 FOS

Genomic Location for FBXL20 Gene

Chromosome:
17
Start:
39,252,644 bp from pter
End:
39,402,661 bp from pter
Size:
150,018 bases
Orientation:
Minus strand

Genomic View for FBXL20 Gene

Genes around FBXL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL20 Gene

Proteins for FBXL20 Gene

  • Protein details for FBXL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IG2-FXL20_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 20
    Protein Accession:
    Q96IG2
    Secondary Accessions:
    • A8K729
    • Q38J52

    Protein attributes for FBXL20 Gene

    Size:
    436 amino acids
    Molecular mass:
    48423 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL20 Gene

Post-translational modifications for FBXL20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL20 Gene

No data available for DME Specific Peptides for FBXL20 Gene

Domains & Families for FBXL20 Gene

Gene Families for FBXL20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FBXL20 Gene

Suggested Antigen Peptide Sequences for FBXL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL20: view

No data available for UniProtKB/Swiss-Prot for FBXL20 Gene

Function for FBXL20 Gene

Molecular function for FBXL20 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).

Phenotypes From GWAS Catalog for FBXL20 Gene

Gene Ontology (GO) - Molecular Function for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 27705803
genes like me logo Genes that share ontologies with FBXL20: view
genes like me logo Genes that share phenotypes with FBXL20: view

Animal Models for FBXL20 Gene

MGI Knock Outs for FBXL20:

Animal Model Products

CRISPR Products

miRNA for FBXL20 Gene

miRTarBase miRNAs that target FBXL20

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXL20
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL20 Gene

Localization for FBXL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL20 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL20: view

Pathways & Interactions for FBXL20 Gene

genes like me logo Genes that share pathways with FBXL20: view

Gene Ontology (GO) - Biological Process for FBXL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0001662 behavioral fear response IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL20: view

No data available for SIGNOR curated interactions for FBXL20 Gene

Drugs & Compounds for FBXL20 Gene

No Compound Related Data Available

Transcripts for FBXL20 Gene

Unigene Clusters for FBXL20 Gene

F-box and leucine-rich repeat protein 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FBXL20
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL20 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: -
SP2: - -
SP3:

Relevant External Links for FBXL20 Gene

GeneLoc Exon Structure for
FBXL20
ECgene alternative splicing isoforms for
FBXL20

Expression for FBXL20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Testis (7.8), Fetal Brain (7.8), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL20 Gene



Protein tissue co-expression partners for FBXL20 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL20 Gene:

FBXL20

SOURCE GeneReport for Unigene cluster for FBXL20 Gene:

Hs.462946

Evidence on tissue expression from TISSUES for FBXL20 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Blood(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FBXL20: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL20 Gene

Orthologs for FBXL20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL20 33 34
  • 99.92 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL20 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL20 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL20 33 34
  • 96.41 (n)
cow
(Bos Taurus)
Mammalia FBXL20 33 34
  • 95.97 (n)
mouse
(Mus musculus)
Mammalia Fbxl20 33 16 34
  • 93.12 (n)
chicken
(Gallus gallus)
Aves FBXL20 33 34
  • 82.58 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL20 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl20 33
  • 77.91 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32529 33
zebrafish
(Danio rerio)
Actinopterygii fbxl20 33 34
  • 77.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007807 33
  • 57.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9003 33 34
  • 57.05 (n)
worm
(Caenorhabditis elegans)
Secernentea C02F5.7 33 34
  • 51.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06051g 33
  • 40.98 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GRR1 33 36
  • 39.19 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER398W 33
  • 37.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01216 33
  • 41.07 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pof2 33
  • 41.01 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2004 33
Species where no ortholog for FBXL20 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBXL20 Gene

ENSEMBL:
Gene Tree for FBXL20 (if available)
TreeFam:
Gene Tree for FBXL20 (if available)

Paralogs for FBXL20 Gene

Paralogs for FBXL20 Gene

(2) SIMAP similar genes for FBXL20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL20: view

Variants for FBXL20 Gene

Sequence variations from dbSNP and Humsavar for FBXL20 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000002468 -- 39,326,608(+) CAGAG(A/C/G)AAGAC intron-variant
rs1000062449 -- 39,277,906(+) TATCA(C/T)GCTGT intron-variant
rs1000069776 -- 39,397,325(+) AAAAA(C/G)AATAA intron-variant
rs1000079000 -- 39,284,868(+) CTTAA(A/C)GTACC intron-variant
rs1000086825 -- 39,402,467(+) AGCTG(C/G)ACCTG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXL20 Gene

Variant ID Type Subtype PubMed ID
esv2132100 CNV deletion 18987734
esv24997 CNV loss 19812545
esv2506125 CNV deletion 19546169
esv2661698 CNV deletion 23128226
esv2671262 CNV deletion 23128226
esv2715900 CNV deletion 23290073
esv3157123 CNV deletion 24192839
esv3554401 CNV deletion 23714750
esv3640544 CNV loss 21293372
nsv1055612 CNV gain 25217958
nsv1072734 CNV deletion 25765185
nsv1109073 CNV deletion 24896259
nsv1138537 CNV deletion 24896259
nsv1138538 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv510709 CNV deletion 20534489
nsv833441 CNV loss 17160897
nsv955409 CNV deletion 24416366

Variation tolerance for FBXL20 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL20 Gene

Human Gene Mutation Database (HGMD)
FBXL20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL20 Gene

Disorders for FBXL20 Gene

Relevant External Links for FBXL20

Genetic Association Database (GAD)
FBXL20
Human Genome Epidemiology (HuGE) Navigator
FBXL20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL20

No disorders were found for FBXL20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL20 Gene

Publications for FBXL20 Gene

  1. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. (PMID: 21399635) Mells GF … Anderson CA (Nature genetics 2011) 3 45 60
  2. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PMID: 19124506) Mavaddat N … Pharoah PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for FBXL20 Gene

Sources for FBXL20 Gene

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