FBXL2 Gene
protein-coding GIFtS: 49
GCID: GC03P033293
|
|
F-box and leucine-rich repeat protein 2
| |
Aliases
for FBXL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 21 2 3 | | FBL21 2 3 5 | | FBL31 2 3 | | F-Box Protein FBL2/FBL32 3 | | F-Box Protein Containing Leucine-Rich Repeats2 | | F-Box/LRR-Repeat Protein 22 |
Export aliases for FBXL2 gene to outside databasesPrevious GC identifers: GC03P032625 GC03P033165 GC03P033290 |
Summaries
for FBXL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL2:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either differentprotein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fblsclass and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2010)
UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9Function: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-proteinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlikemany F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-bindingmotifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity).Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), alsoantagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial forhepatitis C virus RNA replication
Gene Wiki entry for FBXL2
|
Genomic Views
for FBXL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL2 gene promoter:
Max1 Tal-1 AML1a Tal-1beta E47 PPAR-gamma1 STAT3 PPAR-gamma2 ITF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.3 Ensembl cytogenetic band: 3p22.3 HGNC cytogenetic band: 3p22.3FBXL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P033293: view genomic region
(about GC identifiers)
Start:
|
33,318,517 bp from pter |
End:
|
33,445,154 bp from pter |
Size:
|
126,638 bases |
Orientation:
|
plus strand |
|
Proteins
for FBXL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 2 Size: 423 amino acids; 47062 Da
Subunit: Interacts with SKP1. Interacts with PCYT1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (Bysimilarity). Interacts (via CAAX motif) with hepatitis C virus non-structural protein 5A (NS5A). May also interact,but less efficiently, with hepatitis C virus non-structural protein 5B (NS5B). Interacts with CCND2 and CCND3
Subcellular location: Membrane; Lipid-anchor
Miscellaneous: Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of hepatitisC virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A coexpression
Sequence caution: Sequence=AAF03128.1; Type=Erroneous initiation;
Secondary accessions: B4DQV0 E9PD06 Q6IAN3 Q9NVQ8 Q9UK27 Q9UKA5 Q9Y3Y9Alternative splicing: 2 isoforms: Q9UKC9-1 Q9UKC9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBXL2: NX_Q9UKC9
FBXL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165184.1 NP_036289.3
ENSEMBL proteins: ENSP00000417601 ENSP00000411484 ENSP00000411273 ENSP00000416332 ENSP00000405084 ENSP00000426163 ENSP00000406737 ENSP00000408895 ENSP00000441228 ENSP00000440794 ENSP00000389251 ENSP00000445039
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FBXL2 for ontologies About GeneDecksing
FBXL2 Antibody Products:
Assay Products for FBXL2: |
Protein
Domains /
Families
for FBXL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKC9ProtoNet protein and cluster: Q9UKC9 UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9Similarity: Contains 1 F-box domainSimilarity: Contains 13 LRR (leucine-rich) repeats |
Function
for FBXL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9Function: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-proteinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlikemany F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-bindingmotifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity).Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), alsoantagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial forhepatitis C virus RNA replication
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL2 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FBXL2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for FBXL2:
|
Pathways & Interactions
for FBXL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for FBXL2 (Q9UKC92, 3 ENSP000004176014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
FBXL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL2
Search CenterWatch for drugs/clinical trials and news about FBXL2
|
Transcripts
for FBXL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL2 gene (2 alternative transcripts): NM_001171713.1 NM_012157.3 Unigene Cluster for FBXL2: F-box and leucine-rich repeat protein 2 Hs.475872 [show with all ESTs]Unigene Representative Sequence: NM_01215718/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000498807 ENST00000484457(uc003cfp.3 uc011axp.2 uc021wuy.1 uc011axo.2)
ENST00000497411 ENST00000435207(uc011axm.1) ENST00000283627 ENST00000432809
ENST00000451636(uc011axn.1) ENST00000463736(uc011axr.1 uc011axq.1)
ENST00000425973 ENST00000507198 ENST00000422741 ENST00000421391 ENST00000483037
ENST00000493778 ENST00000464164 ENST00000461094 ENST00000463698 ENST00000460186
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AF174589.1 AF176518.1 AF186273.1 AK001271.1 AK001438.1 AK096492.1 AK298967.1 AK302218.1 AK303764.1 AK316383.1 AL049953.1 BC031556.1 CR457121.1 15 DOTS entries: DT.100771036 DT.313433 DT.40106877 DT.100771033 DT.120858919 DT.40131227 DT.86857624 DT.100771026 DT.120858933 DT.100771025 DT.100771034 DT.100799715 DT.120858883 DT.40203430 DT.95151323 24/108 AceView cDNA sequences (see all 108): BU786938 CA843450 BE856969 BU783792 AU124816 AA653344 AK096492 F10520 BI870519 BX431982 BC031556 BX283875 AI079330 AA446220 AK001271 BM695660 AA972025 NM_012157 BE046381 F01360 AA912719 AV729497 CF541397 BM666541
GeneLoc Exon Structure
|
Expression
for FBXL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAATGGAT
About this image
See FBXL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL2
SOURCE GeneReport for Unigene cluster: Hs.475872
UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas and placenta
SABiosciences Expression via Pathway-Focused PCR Array including FBXL2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL2 |
Orthologs
for FBXL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FBXL2 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FBXL21 |
F-box and leucine-rich repeat protein 2 |
80.33(n)
90.52(a) |
|
420722 XM_418823.3 XP_418823.3 |
lizard
(Anolis carolinensis) |
Reptilia |
FBXL26 |
-- |
76(a) |
1 ↔ 1 |
GL343324.1(795981-817272) |
zebrafish
(Danio rerio) |
Actinopterygii |
sbcb7832 |
sbcb783 |
76.36(n) |
|
378737 BC059683.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG90033 |
-- |
55(a) |
|
48B2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C02F5.7a3
C02F5.71 |
Glucose-induced repressor3
Protein C02F5.71 |
49(a)
(best of 2)3
51.97(n)1
49.16(a)1 |
|
35648051 NM_171210.31 NP_741248.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
GRR11 |
Grr1p |
39.29(n)
24.74(a) |
|
853552 NP_012623.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G233401 |
leucine-rich repeats (LRRs), ribonuclease inhibitor more |
43.28(n)
32.46(a) |
|
832398 NM_122240.3 NP_197725.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g06364001 |
hypothetical protein |
44.57(n)
32(a) |
|
4330084 NM_001054058.1 NP_001047523.1 |
ENSEMBL Gene Tree for FBXL2 (if available)
TreeFam Gene Tree for FBXL2 (if available) |
Paralogs
for FBXL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXL2 gene
- FBXL172 FBXL202 ENSG000002371022 FBXL132 FBXL162 FBXL72 AMN12 LRRC292
- FBXL152 FBXL42 FBXL142
7 SIMAP similar genes for FBXL2 using alignment to 10 protein entries: FBXL2_HUMAN (see all proteins):FBXL20 LRRC29 FBXL13 FBXL7 LOC196394 FBXL16
FBXL14
FBXL2 for paralogs About GeneDecksing
|
Genomic Variants
for FBXL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL2 (33318517 - 33445154 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FBXL2
1 CNV: 3424
1 Indel: 33732 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL2 |
|
Disorders
/ Diseases
for FBXL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXL2 for disorders About GeneDecksing
OMIM gene information: 605652
OMIM disorders: --
3  diseases for FBXL2: About MalaCardshepatitis c hepatitis cholesterol
Export disorders for FBXL2 gene to outside databases
|
Publications
for FBXL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with FBXL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
- F-box protein FBXL2 exerts human lung tumor suppressor -like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. (PubMed id 22020328)1, 2 Chen B.B....Mallampalli R.K. (2012)
- F-box protein FBXL2 targets cyclin D2 for ubiquitinati on and degradation to inhibit leukemic cell proliferation. (PubMed id 22323446)1, 2 Chen B.B....Mallampalli R.K. (2012)
- Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. (PubMed id 15893726)1, 2 Wang C....Ye J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
- A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
- Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. (PubMed id 10508920)1, 3 Ilyin G.P....Guguen-Guillouzo C. (1999)
- FBL2 regulates amyloid precursor protein (APP) metabol ism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. (PubMed id 22399757)1 Watanabe T....Horiguchi T. (2012)
|
External Searches for FBXL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL2 gene:
Search GeneIP for patents involving FBXL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FBXL2 | | OriGene shRNA RFP for FBXL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBXL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL2 | | | OriGene Protein Over-expression Lysate for FBXL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBXL2 | | OriGene 3'-UTR Clone for FBXL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL2 |
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| | | | Search Tocris compounds for FBXL2 |
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 | | | FBXL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL2 |
|  |  |  | | | | ThermoFisher Antibody for FBXL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL2 |
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