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FBXL2 Gene

protein-coding   GIFtS: 53
GCID: GC03P033293

F-Box And Leucine-Rich Repeat Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 21 2 3
FBL22 3 5
FBL32 3
F-Box Protein FBL2/FBL32 3
F-Box Protein Containing Leucine-Rich Repeats2
F-Box/LRR-Repeat Protein 22

External Ids:    HGNC: 135981   Entrez Gene: 258272   Ensembl: ENSG000001535587   OMIM: 6056525   UniProtKB: Q9UKC93   

Export aliases for FBXL2 gene to outside databases

Previous GC identifers: GC03P032625 GC03P033165 GC03P033290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FBXL2 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2010)

GeneCards Summary for FBXL2 Gene:
FBXL2 (F-box and leucine-rich repeat protein 2) is a protein-coding gene. Diseases associated with FBXL2 include hepatitis c virus, and hepatitis c. GO annotations related to this gene include ubiquitin-protein ligase activity and calmodulin binding. An important paralog of this gene is FBXL17.

UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9
Function: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but
rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized
by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation,
leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural
protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication

Gene Wiki entry for FBXL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL2 gene promoter:
         Max1   Tal-1   AML1a   Tal-1beta   E47   PPAR-gamma1   STAT3   PPAR-gamma2   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL2 promoter sequence
   Search Chromatin IP Primers for FBXL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.3

FBXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P033293:  view genomic region     (about GC identifiers)

Start:
33,318,517 bp from pter      End:
33,445,154 bp from pter
Size:
126,638 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 2  
Size: 423 amino acids; 47062 Da
Subunit: Interacts with SKP1. Interacts with PCYT1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By
similarity). Interacts (via CAAX motif) with hepatitis C virus non-structural protein 5A (NS5A). May also
interact, but less efficiently, with hepatitis C virus non-structural protein 5B (NS5B). Interacts with CCND2 and
CCND3
Miscellaneous: Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of
hepatitis C virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A
coexpression
Sequence caution: Sequence=AAF03128.1; Type=Erroneous initiation;
Secondary accessions: B4DQV0 E9PD06 Q6IAN3 Q9NVQ8 Q9UK27 Q9UKA5 Q9Y3Y9
Alternative splicing: 2 isoforms:  Q9UKC9-1   Q9UKC9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXL2: NX_Q9UKC9

Explore proteomics data for FBXL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FBXL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001165184.1  NP_036289.3  

    ENSEMBL proteins: 
     ENSP00000417601   ENSP00000411484   ENSP00000411273   ENSP00000416332   ENSP00000405084  
     ENSP00000426163   ENSP00000406737   ENSP00000408895   ENSP00000441228   ENSP00000440794  
     ENSP00000389251   ENSP00000445039  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXL: F-boxes / Leucine-rich repeats

    2 InterPro protein domains:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKC9

    ProtoNet protein and cluster: Q9UKC9

    UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9
    Similarity: Contains 1 F-box domain
    Similarity: Contains 13 LRR (leucine-rich) repeats


    FBXL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL2_HUMAN, Q9UKC9
    Function: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but
    rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized
    by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation,
    leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural
    protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI15893726
    GO:0005516calmodulin binding IEA--
         
    FBXL2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXL2:
     Decreased nuclei size in G2M  Synthetic lethal with Ras  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXL2
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    miRNA
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    miRTarBase miRNAs that target FBXL2:
    hsa-mir-324-3p (MIRT042990), hsa-mir-21-5p (MIRT030985)

    Block miRNA regulation of human, mouse, rat FBXL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FBXL2 (see all 28):
    hsa-miR-3200-5p hsa-miR-892b hsa-miR-4288 hsa-miR-3942-5p hsa-miR-200a hsa-miR-632 hsa-miR-346 hsa-miR-1257
    SwitchGear 3'UTR luciferase reporter plasmidFBXL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXL2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FBXL2_HUMAN, Q9UKC9: Membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10508920
    GO:0016020membrane IDA15893726

    FBXL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FBXL2: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FBXL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FBXL2 (Q9UKC92, 3 ENSP000004176014) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL7A1Q023882, 3, ENSP000003323714MINT-64035 I2D: score=2 STRING: ENSP00000332371
    SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
    APPENSP000002849814STRING: ENSP00000284981
    CUL1ENSP000003268044STRING: ENSP00000326804
    DNAJC2ENSP000003685654STRING: ENSP00000368565
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10531035
    GO:0006508proteolysis TAS10531035
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006513protein monoubiquitination IEA--
    GO:0016032viral process IEA--

    FBXL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FBXL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FBXL2 gene (2 alternative transcripts): 
    NM_001171713.1  NM_012157.3  

    Unigene Cluster for FBXL2:

    F-box and leucine-rich repeat protein 2
    Hs.475872  [show with all ESTs]
    Unigene Representative Sequence: NM_012157
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000498807 ENST00000484457(uc003cfp.3 uc011axp.2 uc021wuy.1 uc011axo.2)
    ENST00000497411 ENST00000435207(uc011axm.1) ENST00000283627 ENST00000432809
    ENST00000451636(uc011axn.1) ENST00000463736(uc011axr.1 uc011axq.1)
    ENST00000425973 ENST00000507198 ENST00000422741 ENST00000421391 ENST00000483037
    ENST00000493778 ENST00000464164 ENST00000461094 ENST00000463698 ENST00000460186

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    Selected qRT-PCR Assays for microRNAs that regulate FBXL2 (see all 28):
    hsa-miR-3200-5p hsa-miR-892b hsa-miR-4288 hsa-miR-3942-5p hsa-miR-200a hsa-miR-632 hsa-miR-346 hsa-miR-1257
    SwitchGear 3'UTR luciferase reporter plasmidFBXL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FBXL2
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat FBXL2

    Additional mRNA sequence: 

    AF174589.1 AF176518.1 AF186273.1 AK001271.1 AK001438.1 AK096492.1 AK298967.1 AK302218.1 
    AK303764.1 AK316383.1 AL049953.1 BC031556.1 CR457121.1 

    15 DOTS entries:

    DT.100771036  DT.313433  DT.40106877  DT.100771033  DT.120858919  DT.40131227  DT.86857624  DT.100771026 
    DT.120858933  DT.100771025  DT.100771034  DT.100799715  DT.120858883  DT.40203430  DT.95151323 

    Selected AceView cDNA sequences (see all 108):

    BM263894 AV729497 AI653559 BM695660 F10520 AL535858 AA972025 NM_012157 
    AA912719 AK001271 BC031556 AK096492 AF176518 BI870519 BE046381 BU786938 
    BX431982 AW264058 CF541397 F01360 AA653344 AU124816 CA843450 AA446220 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FBXL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATGGAT
    FBXL2 Expression
    About this image


    FBXL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    FBXL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FBXL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.475872

    UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including FBXL2: 
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FBXL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl21 , 5 F-box and leucine-rich repeat protein 21, 5 87.94(n)1
    95.98(a)1
      9 (64.17 cM)5
    721791  NM_178624.61  NP_848739.11 
     1139636375 
    chicken
    (Gallus gallus)
    Aves FBXL21 F-box and leucine-rich repeat protein 2 80.33(n)
    90.52(a)
      420722  XM_418823.4  XP_418823.4 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL26
    F-box and leucine-rich repeat protein 2
    76(a)
    1 ↔ 1
    GL343324.1(786687-817272)
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb7832 sbcb783 76.36(n)   378737  BC059683.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90033   -- 55(a)   48B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C02F5.7a3 Glucose-induced repressor 49(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for FBXL2 (if available)
    TreeFam Gene Tree for FBXL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FBXL2 gene
    FBXL172  FBXL202  ENSG000002371022  FBXL132  FBXL162  FBXL72  LRRC292  FBXL152  
    FBXL142  FBXL42  
    7 SIMAP similar genes for FBXL2 using alignment to 10 protein entries:     FBXL2_HUMAN (see all proteins):
    FBXL20    LRRC29    FBXL13    FBXL7    AMN1    FBXL16
    FBXL14

    FBXL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FBXL2 (see all 1957)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360714
    A colorectal cancer sample4--see VAR_0360712 V M mis40--------
    rs1888980351,2
    --33316975(+) CATGAG/TGACAG 2 -- us2k10--------
    rs1914831291,2
    --33317068(+) GGACAC/GAAACA 2 -- us2k10--------
    rs578123121,2
    C--33317220(+) ACAGCG/AGAATC 2 -- us2k14Minor allele frequency- A:0.05NA WA EA 360
    rs1836807871,2
    --33317340(+) ATTACA/GTTGTG 2 -- us2k10--------
    rs1887836561,2
    --33317513(+) TCACTC/GCTTCC 2 -- us2k10--------
    rs710701291,2
    C--33317515(-) GGGAG-/GGAA  
            
    GGAAG
    2 -- us2k11Minor allele frequency- GGAA:0.00NA 2
    rs1125318541,2
    C,F--33317543(+) CCTCCC/TTCTCT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs602424641,2
    C--33317557(+) TTTTT-/TGAGAC 2 -- us2k10--------
    rs1410218551,2
    --33317714(+) CCATGA/CCGGCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXL2 (33318517 - 33445154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822052CNV Loss20364138
    nsv522292CNV Loss19592680
    nsv876680CNV Loss21882294
    nsv876679CNV Loss21882294
    nsv10258CNV Loss18304495
    nsv834653CNV Loss17160897
    nsv525895CNV Gain19592680
    dgv1445e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605652    OMIM disorders: --

    8 diseases for FBXL2:    
    About MalaCards
    hepatitis c virus    hepatitis c    breast and colorectal cancer    hepatitis
    alzheimer's disease    colorectal cancer    endotheliitis    neuronitis


    FBXL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXL2

    Export disorders for FBXL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FBXL2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with FBXL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (Curr. Biol. 1999)
    2. F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. (PubMed id 22020328)1, 2 Chen B.B.... Mallampalli R.K. (Oncogene 2012)
    3. F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. (PubMed id 22323446)1, 2 Chen B.B.... Mallampalli R.K. (Blood 2012)
    4. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. (PubMed id 15893726)1, 2 Wang C.... Ye J. (Mol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (Genomics 2000)
    8. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T.... Harper J.W. (Curr. Biol. 1999)
    9. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. (PubMed id 10508920)1, 3 Ilyin G.P....Guguen-Guillouzo C. (FEBS Lett. 1999)
    10. Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. (PubMed id 23370391)1 Mallampalli R.K....Chen B.B. (Cell Cycle 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25827 HGNC: 13598 AceView: FBXL2 Ensembl:ENSG00000153558 euGenes: HUgn25827
    ECgene: FBXL2 H-InvDB: FBXL2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FBXL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FBXL2 gene:
    Search GeneIP for patents involving FBXL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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