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Aliases for FBXL2 Gene

Aliases for FBXL2 Gene

  • F-Box And Leucine-Rich Repeat Protein 2 2 3 4
  • FBL2 3 4 6
  • F-Box Protein FBL2/FBL3 3 4
  • FBL3 3 4
  • F-Box Protein Containing Leucine-Rich Repeats 3
  • F-Box/LRR-Repeat Protein 2 3

External Ids for FBXL2 Gene

Previous GeneCards Identifiers for FBXL2 Gene

  • GC03P032625
  • GC03P033165
  • GC03P033290

Summaries for FBXL2 Gene

Entrez Gene Summary for FBXL2 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for FBXL2 Gene

FBXL2 (F-Box And Leucine-Rich Repeat Protein 2) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and calmodulin binding. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL2 Gene

  • Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Gene Wiki entry for FBXL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL2 Gene

Genomics for FBXL2 Gene

Regulatory Elements for FBXL2 Gene

Genomic Location for FBXL2 Gene

Start:
33,277,025 bp from pter
End:
33,403,662 bp from pter
Size:
126,638 bases
Orientation:
Plus strand

Genomic View for FBXL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL2 Gene

Proteins for FBXL2 Gene

  • Protein details for FBXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKC9-FBXL2_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 2
    Protein Accession:
    Q9UKC9
    Secondary Accessions:
    • B4DQV0
    • E9PD06
    • Q6IAN3
    • Q9NVQ8
    • Q9UK27
    • Q9UKA5
    • Q9Y3Y9

    Protein attributes for FBXL2 Gene

    Size:
    423 amino acids
    Molecular mass:
    47062 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL2) composed of CUL1, SKP1, RBX1 and FBXL2 (PubMed:10531037). Interacts with PCYT1A. Interacts with calmodulin; may antagonize substrate ubiquitination by SCF(FBXL2) (By similarity). Interacts with CCND2 and CCND3 (PubMed:22323446, PubMed:22020328). Interacts with PIK3R2; PIK3R2 is a substrate ubiquitinated by the SCF(FBXL2) complex (PubMed:23604317). May interact with PIK3R1 (PubMed:23604317). Interacts with PTPN13. Interacts with hepatitis C virus non-structural protein 5A (NS5A) and less efficiently, with hepatitis C virus non-structural protein 5B (NS5B); a reaction crucial for hepatitis C virus RNA replication (PubMed:15893726).
    Miscellaneous:
    • Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of hepatitis C virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A coexpression.
    SequenceCaution:
    • Sequence=AAF03128.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL2 Gene

Proteomics data for FBXL2 Gene at MOPED

Post-translational modifications for FBXL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL2 Gene

Domains for FBXL2 Gene

Gene Families for FBXL2 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKC9

UniProtKB/Swiss-Prot:

FBXL2_HUMAN :
  • Q9UKC9
Domain:
  • The CAAX motif is a signal for the geranylgeranylation of FBXL2 and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex.
  • Contains 1 F-box domain.
Similarity:
  • Contains 13 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL2: view

Function for FBXL2 Gene

Molecular function for FBXL2 Gene

UniProtKB/Swiss-Prot Function: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation may induce cell-cycle arrest in G(0). SCF(FBXL2) may also mediate PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and indirectly autophagy (PubMed:22323446, PubMed:22020328, PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation may regulate synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Gene Ontology (GO) - Molecular Function for FBXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 23604317
GO:0005515 protein binding IPI 15893726
GO:0005516 calmodulin binding IEA --
GO:0019903 protein phosphatase binding IPI 23604317
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IPI 23604317
genes like me logo Genes that share ontologies with FBXL2: view
genes like me logo Genes that share phenotypes with FBXL2: view

Animal Model Products

CRISPR Products

miRNA for FBXL2 Gene

miRTarBase miRNAs that target FBXL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXL2 Gene

Localization for FBXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL2 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL2 Gene COMPARTMENTS Subcellular localization image for FBXL2 gene
Compartment Confidence
extracellular 2
cytosol 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10508920
GO:0016020 membrane IDA 15893726
GO:0019005 SCF ubiquitin ligase complex IDA 23604317
genes like me logo Genes that share ontologies with FBXL2: view

Pathways for FBXL2 Gene

SuperPathways for FBXL2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FBXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 10531035
GO:0006508 proteolysis TAS 10531035
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0006513 protein monoubiquitination IEA --
GO:0010506 regulation of autophagy IMP 23604317
genes like me logo Genes that share ontologies with FBXL2: view

No data available for Pathways by source for FBXL2 Gene

Transcripts for FBXL2 Gene

Unigene Clusters for FBXL2 Gene

F-box and leucine-rich repeat protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL2 Gene

No ASD Table

Relevant External Links for FBXL2 Gene

GeneLoc Exon Structure for
FBXL2
ECgene alternative splicing isoforms for
FBXL2

Expression for FBXL2 Gene

mRNA expression in normal human tissues for FBXL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL2 Gene

This gene is overexpressed in Brain - Cortex (4.1) and Brain - Frontal Cortex (BA9) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL2 Gene

SOURCE GeneReport for Unigene cluster for FBXL2 Gene Hs.475872

mRNA Expression by UniProt/SwissProt for FBXL2 Gene

Q9UKC9-FBXL2_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
genes like me logo Genes that share expressions with FBXL2: view

In Situ Assay Products

Orthologs for FBXL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL2 35
  • 100 (n)
  • 100 (a)
FBXL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL2 35
  • 88.81 (n)
  • 95.27 (a)
FBXL2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL2 35
  • 93.84 (n)
  • 99.05 (a)
FBXL2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl2 35
  • 87.94 (n)
  • 95.98 (a)
Fbxl2 16
Fbxl2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl2 35
  • 87.39 (n)
  • 95.98 (a)
chicken
(Gallus gallus)
Aves FBXL2 35
  • 80.33 (n)
  • 90.52 (a)
FBXL2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL2 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbxl2 35
  • 74.41 (n)
  • 80.81 (a)
fbxl2 36
  • 79 (a)
OneToOne
sbcb783 35
fruit fly
(Drosophila melanogaster)
Insecta CG9003 36
  • 36 (a)
OneToMany
CG9003 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea C02F5.7 36
  • 44 (a)
OneToMany
C02F5.7a 37
  • 49 (a)
C02F5.7b 37
  • 48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06250 35
  • 41.92 (n)
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for FBXL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FBXL2 Gene

ENSEMBL:
Gene Tree for FBXL2 (if available)
TreeFam:
Gene Tree for FBXL2 (if available)

Paralogs for FBXL2 Gene

Paralogs for FBXL2 Gene

genes like me logo Genes that share paralogs with FBXL2: view

Variants for FBXL2 Gene

Sequence variations from dbSNP and Humsavar for FBXL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs491875 -- 33,364,437(-) AATGG(G/T)CCAAT intron-variant
rs563109 -- 33,386,766(-) GGAGC(A/G)AGAAT utr-variant-3-prime, intron-variant
rs595695 -- 33,380,924(-) AAGAA(C/G)TTGAG intron-variant
rs795937 -- 33,380,480(-) cccag(G/T)ttcaa intron-variant
rs795938 -- 33,380,435(-) gatta(C/T)aggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL2 Gene

Variant ID Type Subtype PubMed ID
nsv834653 CNV Loss 17160897
dgv1445e1 CNV Complex 17122850
nsv522292 CNV Loss 19592680
nsv525895 CNV Gain 19592680
nsv876679 CNV Loss 21882294
nsv876680 CNV Loss 21882294
nsv10258 CNV Loss 18304495
nsv822052 CNV Loss 20364138

Relevant External Links for FBXL2 Gene

HapMap Linkage Disequilibrium report
FBXL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL2 Gene

Disorders for FBXL2 Gene

Relevant External Links for FBXL2

Genetic Association Database (GAD)
FBXL2
genes like me logo Genes that share disorders with FBXL2: view

No data available for UniProtKB/Swiss-Prot for FBXL2 Gene

Publications for FBXL2 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 3 4
  3. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PMID: 10945468) Ilyin G.P. … Guguen-Guillouzo C. (Genomics 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

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