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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL2 Gene

protein-coding   GIFtS: 53
GCID: GC03P033293

F-Box And Leucine-Rich Repeat Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And Leucine-Rich Repeat Protein 21 2 3
FBL22 3 5
FBL32 3
F-Box Protein FBL2/FBL32 3
F-Box Protein Containing Leucine-Rich Repeats2
F-Box/LRR-Repeat Protein 22

External Ids:    HGNC: 135981   Entrez Gene: 258272   Ensembl: ENSG000001535587   OMIM: 6056525   UniProtKB: Q9UKC93   

Export aliases for FBXL2 gene to outside databases

Previous GC identifers: GC03P032625 GC03P033165 GC03P033290


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXL2 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2010)

GeneCards Summary for FBXL2 Gene: 
FBXL2 (F-box and leucine-rich repeat protein 2) is a protein-coding gene. Diseases associated with FBXL2 include hepatitis c, and hepatitis. GO annotations related to this gene include ubiquitin-protein ligase activity and calmodulin binding. An important paralog of this gene is FBXL17.

UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9
Function: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but
rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized
by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation,
leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural
protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication

Gene Wiki entry for FBXL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL2 gene promoter:
         Max1   Tal-1   AML1a   Tal-1beta   E47   PPAR-gamma1   STAT3   PPAR-gamma2   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBXL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.3

FBXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P033293:  view genomic region     (about GC identifiers)

Start:
33,318,517 bp from pter      End:
33,445,154 bp from pter
Size:
126,638 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 2  
Size: 423 amino acids; 47062 Da
Subunit: Interacts with SKP1. Interacts with PCYT1A. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By
similarity). Interacts (via CAAX motif) with hepatitis C virus non-structural protein 5A (NS5A). May also
interact, but less efficiently, with hepatitis C virus non-structural protein 5B (NS5B). Interacts with CCND2 and
CCND3
Subcellular location: Membrane; Lipid-anchor
Miscellaneous: Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of
hepatitis C virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A
coexpression
Sequence caution: Sequence=AAF03128.1; Type=Erroneous initiation;
Secondary accessions: B4DQV0 E9PD06 Q6IAN3 Q9NVQ8 Q9UK27 Q9UKA5 Q9Y3Y9
Alternative splicing: 2 isoforms:  Q9UKC9-1   Q9UKC9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FBXL2: NX_Q9UKC9

Explore proteomics data for FBXL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKC9

  • FBXL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXL2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165184.1  NP_036289.3  

    ENSEMBL proteins: 
     ENSP00000417601   ENSP00000411484   ENSP00000411273   ENSP00000416332   ENSP00000405084  
     ENSP00000426163   ENSP00000406737   ENSP00000408895   ENSP00000441228   ENSP00000440794  
     ENSP00000389251   ENSP00000445039  

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    Cloud-Clone Corp. Proteins for FBXL2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10508920
    GO:0016020membrane IDA15893726

    FBXL2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXL: F-boxes / Leucine-rich repeats

    2 InterPro protein domains:
     IPR006553 Leu-rich_rpt_Cys-con_subtyp
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9UKC9

    ProtoNet protein and cluster: Q9UKC9

    UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9
    Similarity: Contains 1 F-box domain
    Similarity: Contains 13 LRR (leucine-rich) repeats


    FBXL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FBXL2_HUMAN, Q9UKC9
    Function: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but
    rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized
    by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation,
    leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural
    protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI15893726
    GO:0005516calmodulin binding IEA--
         
    FBXL2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXL2:
     Decreased nuclei size in G2M  Synthetic lethal with Ras  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL2 
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    SwitchGear 3'UTR luciferase reporter plasmidFBXL2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for FBXL2 (Q9UKC92, 3 ENSP000004176014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL7A1Q023882, 3, ENSP000003323714MINT-64035 I2D: score=2 STRING: ENSP00000332371
    SKP1P632083, ENSP000002314874I2D: score=1 STRING: ENSP00000231487
    APPENSP000002849814STRING: ENSP00000284981
    CUL1ENSP000003268044STRING: ENSP00000326804
    PPP1CCENSP000003350844STRING: ENSP00000335084
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS10531035
    GO:0006508proteolysis TAS10531035
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0006513protein monoubiquitination IEA--
    GO:0019048modulation by virus of host morphology or physiology IEA--

    FBXL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXL2

    Search CenterWatch for drugs/clinical trials and news about FBXL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXL2 gene (2 alternative transcripts): 
    NM_001171713.1  NM_012157.3  

    Unigene Cluster for FBXL2:

    F-box and leucine-rich repeat protein 2
    Hs.475872  [show with all ESTs]
    Unigene Representative Sequence: NM_012157
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000498807 ENST00000484457(uc003cfp.3 uc011axp.2 uc021wuy.1 uc011axo.2)
    ENST00000497411 ENST00000435207(uc011axm.1) ENST00000283627 ENST00000432809
    ENST00000451636(uc011axn.1) ENST00000463736(uc011axr.1 uc011axq.1)
    ENST00000425973 ENST00000507198 ENST00000422741 ENST00000421391 ENST00000483037
    ENST00000493778 ENST00000464164 ENST00000461094 ENST00000463698 ENST00000460186

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    SwitchGear 3'UTR luciferase reporter plasmidFBXL2 3' UTR sequence
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    Additional mRNA sequence: 

    AF174589.1 AF176518.1 AF186273.1 AK001271.1 AK001438.1 AK096492.1 AK298967.1 AK302218.1 
    AK303764.1 AK316383.1 AL049953.1 BC031556.1 CR457121.1 

    15 DOTS entries:

    DT.100771036  DT.313433  DT.40106877  DT.100771033  DT.120858919  DT.40131227  DT.86857624  DT.100771026 
    DT.120858933  DT.100771025  DT.100771034  DT.100799715  DT.120858883  DT.40203430  DT.95151323 

    24/108 AceView cDNA sequences (see all 108):

    AA446220 F10520 AF186273 AK001438 NM_012157 AA972025 BM263894 BX431982 
    AV729497 AI564313 BU786938 AI653559 AK001271 AA653344 BE046381 AI079330 
    BU783792 AU124816 BE856969 BM666541 AA912719 AL535858 CF541397 AI926151 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL2 expression in normal human tissues (normalized intensities)      FBXL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATGGAT
    FBXL2 Expression
    About this image


    FBXL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             prefrontal cortex   
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood

    See FBXL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL2

    SOURCE GeneReport for Unigene cluster: Hs.475872

    UniProtKB/Swiss-Prot: FBXL2_HUMAN, Q9UKC9
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including FBXL2: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FBXL2 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl21 , 5 F-box and leucine-rich repeat protein 21, 5 87.94(n)1
    95.98(a)1
      9 (64.17 cM)5
    721791  NM_178624.61  NP_848739.11 
     1139636375 
    chicken
    (Gallus gallus)
    Aves FBXL21 F-box and leucine-rich repeat protein 2 80.33(n)
    90.52(a)
      420722  XM_418823.3  XP_418823.3 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343324.1(786687-817272)
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb7832 sbcb783 76.36(n)   378737  BC059683.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90033   -- 55(a)   48B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea C02F5.7a3
    C02F5.71
    Glucose-induced repressor3
    Protein C02F5.71
    49(a)
    (best of 2)3
    51.97(n)1
    49.16(a)1
      35648051  NM_171210.31  NP_741248.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GRR11 Grr1p 39.29(n)
    24.74(a)
      853552   NP_012623.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G233401 leucine-rich repeats (LRRs), ribonuclease inhibitor more 43.28(n)
    32.46(a)
      832398  NM_122240.3  NP_197725.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06364001 hypothetical protein 44.57(n)
    32(a)
      4330084  NM_001054058.1  NP_001047523.1 


    ENSEMBL Gene Tree for FBXL2 (if available)
    TreeFam Gene Tree for FBXL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXL2 gene
    FBXL172  FBXL202  ENSG000002371022  FBXL132  FBXL162  FBXL72  LRRC292  FBXL152  
    FBXL142  FBXL42  
    7 SIMAP similar genes for FBXL2 using alignment to 10 protein entries:     FBXL2_HUMAN (see all proteins):
    FBXL20    LRRC29    FBXL13    FBXL7    AMN1    FBXL16
    FBXL14

    FBXL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1957 SNPs in FBXL2 are shown (see all 1957)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360714
    A colorectal cancer sample4--see VAR_0360712 V M mis40--------
    rs1888980351,2
    --33316975(+) CATGAG/TGACAG 2 -- us2k10--------
    rs1914831291,2
    --33317068(+) GGACAC/GAAACA 2 -- us2k10--------
    rs578123121,2
    C--33317220(+) ACAGCG/AGAATC 2 -- us2k14Minor allele frequency- A:0.05NA WA EA 360
    rs1836807871,2
    --33317340(+) ATTACA/GTTGTG 2 -- us2k10--------
    rs1887836561,2
    --33317513(+) TCACTC/GCTTCC 2 -- us2k10--------
    rs710701291,2
    C--33317515(-) GGGAG-/GGAA  
            
    GGAAG
    2 -- us2k11Minor allele frequency- GGAA:0.00NA 2
    rs1125318541,2
    C,F--33317543(+) CCTCCC/TTCTCT 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs602424641,2
    C--33317557(+) TTTTT-/TGAGAC 2 -- us2k10--------
    rs1410218551,2
    --33317714(+) CCATGA/CCGGCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FBXL2 (33318517 - 33445154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for FBXL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv822052CNV Loss20364138
    nsv522292CNV Loss19592680
    nsv876680CNV Loss21882294
    nsv876679CNV Loss21882294
    nsv10258CNV Loss18304495
    nsv834653CNV Loss17160897
    nsv525895CNV Gain19592680
    dgv1445e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605652    OMIM disorders: --

    2 diseases for FBXL2:    About MalaCards
    hepatitis c    hepatitis


    FBXL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FBXL2

    Export disorders for FBXL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with FBXL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of human F-box proteins. (PubMed id 10531035)1, 2, 3 Cenciarelli C....Pagano M. (1999)
    2. F-box protein FBXL2 exerts human lung tumor suppressor -like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. (PubMed id 22020328)1, 2 Chen B.B....Mallampalli R.K. (2012)
    3. F-box protein FBXL2 targets cyclin D2 for ubiquitinati on and degradation to inhibit leukemic cell proliferation. (PubMed id 22323446)1, 2 Chen B.B....Mallampalli R.K. (2012)
    4. Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. (PubMed id 15893726)1, 2 Wang C....Ye J. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. cDNA cloning and expression analysis of new members of the mammalian F-box protein family. (PubMed id 10945468)1, 2 Ilyin G.P.... Guguen-Guillouzo C. (2000)
    8. A family of mammalian F-box proteins. (PubMed id 10531037)1, 2 Winston J.T....Harper J.W. (1999)
    9. Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats. (PubMed id 10508920)1, 3 Ilyin G.P....Guguen-Guillouzo C. (1999)
    10. Calmodulin protects Aurora B on the midbody to regulat e the fidelity of cytokinesis. (PubMed id 23370391)1 Mallampalli R.K....Chen B.B. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25827 HGNC: 13598 AceView: FBXL2 Ensembl:ENSG00000153558 euGenes: HUgn25827
    ECgene: FBXL2 H-InvDB: FBXL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXL2 gene:
    Search GeneIP for patents involving FBXL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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