Aliases for FBXL2 Gene
Aliases for FBXL2 Gene
External Ids for FBXL2 Gene
- HGNC: 13598
- Entrez Gene: 25827
- Ensembl: ENSG00000153558
- OMIM: 605652
- UniProtKB: Q9UKC9
Previous GeneCards Identifiers for FBXL2 Gene
- GC03P032625
- GC03P033165
- GC03P033290
Summaries for FBXL2 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for FBXL2 Gene
FBXL2 (F-Box And Leucine Rich Repeat Protein 2) is a Protein Coding gene. Diseases associated with FBXL2 include Hepatitis C Virus. GO annotations related to this gene include ubiquitin-protein transferase activity and protein phosphatase binding. An important paralog of this gene is FBXL20.
UniProtKB/Swiss-Prot for FBXL2 Gene
-
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL2 Gene
Genomics for FBXL2 Gene
Regulatory Elements for FBXL2 Gene
Enhancers for FBXL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03G033437 | 1.4 | ENCODE dbSUPER | 20.5 | +162.9 | 162912 | 5.5 | CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 | PDCD6IP FBXL2 UBP1 TMPPE CMTM6 PIR40256 GC03M033417 |
| GH03G033425 | 1.3 | Ensembl ENCODE dbSUPER | 20.7 | +151.1 | 151108 | 5.7 | PKNOX1 FEZF1 TCF12 EGR2 ZNF680 CEBPB OVOL3 ZNF843 PRDM6 GLIS1 | FBXL2 UBP1 GC03M033417 PIR40256 |
| GH03G033372 | 1.1 | Ensembl ENCODE | 22.4 | +95.9 | 95874 | 0.6 | CTCF PKNOX1 ATF1 TBL1XR1 WRNIP1 JUN ZNF2 RAD21 FOSL1 GATA2 | FBXL2 RNU7-110P |
| GH03G033577 | 1.4 | FANTOM5 Ensembl ENCODE | 15.1 | +301.5 | 301544 | 2.8 | SOX13 FOXA2 JUN TEAD4 CEBPG CHD7 TEAD3 ZNF316 POLR2A FOS | FBXL2 CLASP2 UBP1 COX6CP10 GC03M033644 |
| GH03G033355 | 1 | Ensembl ENCODE | 20.9 | +78.8 | 78801 | 1.1 | HDAC1 PKNOX1 ATF1 ARNT CEBPG SCRT2 RNF2 ARID1B JUND HDAC2 | FBXL2 SUSD5 UBP1 RNU7-110P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXL2 gene promoter:
Regulatory Element Products
Genomic Location for FBXL2 Gene
- Chromosome:
- 3
- Start:
- 33,277,025 bp from pter
- End:
- 33,403,662 bp from pter
- Size:
- 126,638 bases
- Orientation:
- Plus strand
Genomic View for FBXL2 Gene
Genes around FBXL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p22.3 by Ensembl
- 3p22.3 by Entrez Gene
- 3p22.3 by HGNC
FBXL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL2 Gene
Proteins for FBXL2 Gene
-
Protein details for FBXL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKC9-FBXL2_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 2
- Protein Accession:
- Q9UKC9
- B4DQV0
- E9PD06
- Q6IAN3
- Q9NVQ8
- Q9UK27
- Q9UKA5
- Q9Y3Y9
Protein attributes for FBXL2 Gene
- Size:
- 423 amino acids
- Molecular mass:
- 47062 Da
- Quaternary structure:
-
- Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL2) composed of CUL1, SKP1, RBX1 and FBXL2 (PubMed:10531037). Interacts with PCYT1A. Interacts with calmodulin; may antagonize substrate ubiquitination by SCF(FBXL2) (By similarity). Interacts with CCND2 and CCND3 (PubMed:22323446, PubMed:22020328). Interacts with PIK3R2; PIK3R2 is a substrate ubiquitinated by the SCF(FBXL2) complex (PubMed:23604317). May interact with PIK3R1 (PubMed:23604317). Interacts with PTPN13. Interacts with hepatitis C virus non-structural protein 5A (NS5A) and less efficiently, with hepatitis C virus non-structural protein 5B (NS5B); a reaction crucial for hepatitis C virus RNA replication (PubMed:15893726).
- Miscellaneous:
-
- Deletion of the F-box domain creates a dominant-negative protein that inhibits replication of hepatitis C virus RNA when overexpressed in a hepatoma cell line; this inhibition could be overcome by NS5A coexpression.
- SequenceCaution:
-
- Sequence=AAF03128.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FBXL2 Gene
Post-translational modifications for FBXL2 Gene
Other Protein References for FBXL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL2
-
Abcam antibodies for FBXL2
- Invitrogen Antibodies for FBXL2
- antibodies-online Antibodies for FBXL2: See all 39
- GeneTex FBXL2 antibody for FBXL2
Protein Products
-
OriGene Purified Proteins for FBXL2
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL2
- Origene Custom Protein Services for FBXL2
- antibodies-online Proteins for FBXL2: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL2
-
Abcam proteins for FBXL2
Assay Products
- antibodies-online Kits for FBXL2: See all 21
No data available for DME Specific Peptides for FBXL2 Gene
Domains & Families for FBXL2 Gene
Gene Families for FBXL2 Gene
Protein Domains for FBXL2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UKC9UniProtKB/Swiss-Prot:
FBXL2_HUMAN :- The CAAX motif is a signal for the geranylgeranylation of FBXL2 and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex.
- Domain:
-
- The CAAX motif is a signal for the geranylgeranylation of FBXL2 and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex.
Function for FBXL2 Gene
Molecular function for FBXL2 Gene
- UniProtKB/Swiss-Prot Function:
- Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IDA | 23604317 |
| GO:0005515 | protein binding | IPI | 15893726 |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0019903 | protein phosphatase binding | IPI | 23604317 |
| GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding | IPI | 23604317 |
Phenotypes for FBXL2 Gene
- GenomeRNAi human phenotypes for FBXL2:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased viability in esophageal squamous lineage
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Increased cell number in S
- Increased shRNA abundance (Z-score > 2)
- Upregulation of NF-kappaB pathway after LMP1 stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL2 gene
- Search ViGene Biosciences for FBXL2
CRISPR Products
-
OriGene CRISPR knockouts for FBXL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL2
- GenScript: Design CRISPR guide RNA sequences for FBXL2
miRNA for FBXL2 Gene
- miRTarBase miRNAs that target FBXL2
-
- hsa-mir-21-5p (MIRT030985)
- hsa-mir-324-3p (MIRT042990)
- hsa-mir-129-5p (MIRT642082)
- hsa-mir-8055 (MIRT642083)
- hsa-mir-8057 (MIRT642084)
- hsa-mir-6864-3p (MIRT642085)
- hsa-mir-3672 (MIRT642086)
- hsa-mir-6879-3p (MIRT642087)
- hsa-mir-760 (MIRT642088)
- hsa-mir-6822-3p (MIRT642089)
- hsa-mir-4294 (MIRT642090)
- hsa-mir-215-3p (MIRT642091)
- hsa-mir-6773-3p (MIRT642092)
- hsa-mir-6504-5p (MIRT642093)
- hsa-mir-3064-5p (MIRT642094)
- hsa-mir-149-5p (MIRT642095)
- hsa-mir-664a-5p (MIRT642096)
- hsa-mir-4794 (MIRT642097)
- hsa-mir-500b-3p (MIRT642098)
- hsa-mir-6848-3p (MIRT669941)
- hsa-mir-6843-3p (MIRT669942)
- hsa-mir-6878-3p (MIRT669943)
- hsa-mir-640 (MIRT669944)
- hsa-mir-378a-5p (MIRT669945)
- hsa-mir-6744-3p (MIRT669946)
- hsa-mir-4757-5p (MIRT669947)
- hsa-mir-6778-3p (MIRT669948)
- hsa-mir-6821-3p (MIRT669949)
- hsa-mir-6790-3p (MIRT669950)
- hsa-mir-3663-5p (MIRT669951)
- hsa-mir-3653-5p (MIRT669952)
- hsa-mir-372-5p (MIRT669953)
- hsa-mir-371a-5p (MIRT669954)
- hsa-mir-616-5p (MIRT669955)
- hsa-mir-373-5p (MIRT669956)
- hsa-mir-371b-5p (MIRT669957)
- hsa-mir-212-5p (MIRT669958)
- hsa-mir-3934-5p (MIRT669959)
- hsa-mir-764 (MIRT669960)
- hsa-mir-125a-3p (MIRT669961)
- hsa-mir-6131 (MIRT676321)
- hsa-mir-6793-3p (MIRT679719)
- hsa-mir-512-3p (MIRT679720)
- hsa-mir-520e (MIRT679721)
- hsa-mir-520d-3p (MIRT679722)
- hsa-mir-520c-3p (MIRT679723)
- hsa-mir-520b (MIRT679724)
- hsa-mir-520a-3p (MIRT679725)
- hsa-mir-373-3p (MIRT679726)
- hsa-mir-372-3p (MIRT679727)
- hsa-mir-302e (MIRT679728)
- hsa-mir-302d-3p (MIRT679729)
- hsa-mir-302c-3p (MIRT679730)
- hsa-mir-302b-3p (MIRT679731)
- hsa-mir-302a-3p (MIRT679732)
miRNA Products
- Search ViGene Biosciences for FBXL2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FBXL2
- Browse OriGene Inhibitory RNA Products For FBXL2
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL2 gene
Clone Products
- Sino Biological Human cDNA Clone for FBXL2
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Cell Line Products
-
Horizon Cell Lines for FBXL2
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL2 Gene
Localization for FBXL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL2 Gene
- Membrane; Lipid-anchor.
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | TAS | 10508920 |
| GO:0016020 | membrane | IDA,IEA | 15893726 |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 23604317 |
Pathways & Interactions for FBXL2 Gene
No Data Available
Interacting Proteins for FBXL2 Gene
Selected Interacting proteins:
ENSP00000417601
Q9UKC9-FBXL2_HUMAN
for FBXL2 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | TAS | 10531035 |
| GO:0006508 | proteolysis | TAS | 10531035 |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0006513 | protein monoubiquitination | IEA | -- |
| GO:0010506 | regulation of autophagy | IMP | 23604317 |
No data available for Pathways by source and SIGNOR curated interactions for FBXL2 Gene
Transcripts for FBXL2 Gene
mRNA/cDNA for FBXL2 Gene
- (19) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (108) Selected AceView cDNA sequences:
- (22) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL2
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miRNA Products
- Search ViGene Biosciences for FBXL2
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for FBXL2
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL2 gene
Clone Products
- Sino Biological Human cDNA Clone for FBXL2
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Flow Cytometry Products
Expression for FBXL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Eye (Sensory Organs)
- Mesenchymal Stem Cells
mRNA differential expression in normal tissues according to GTEx for FBXL2 Gene
This gene is overexpressed in Brain - Cortex (x4.1) and Brain - Frontal Cortex (BA9) (x4.0).
This gene is overexpressed in Retina (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXL2 Gene:
FBXL2SOURCE GeneReport for Unigene cluster for FBXL2 Gene:
Hs.475872mRNA Expression by UniProt/SwissProt for FBXL2 Gene:
Q9UKC9-FBXL2_HUMAN
Tissue specificity:
Expressed in brain, heart, kidney, liver, lung, pancreas and placenta.
Evidence on tissue expression from TISSUES for FBXL2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for FBXL2
-
OriGene qPCR primer pairs and template standards for FBXL2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL2 Gene
Orthologs for FBXL2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FBXL2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl2 16 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl2 34 |
|
||
| chicken (Gallus gallus) |
Aves | FBXL2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | fbxl2 34 35 |
|
||
| sbcb783 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9003 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C02F5.7a 36 |
|
|
|
| C02F5.7b 36 |
|
|
|||
| C02F5.7 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06250 34 |
|
- Species where no ortholog for FBXL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for FBXL2 Gene
Paralogs for FBXL2 Gene
(7) SIMAP similar genes for FBXL2 Gene using alignment to 10 proteins:
Variants for FBXL2 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036071 | A colorectal cancer sample | ||||
| rs1000010952 | -- | 33,294,394(+) | GCCTG(A/G)CCCCA | intron-variant | |
| rs1000021124 | -- | 33,287,815(+) | CAGTG(C/T)CTGGC | intron-variant, upstream-variant-2KB | |
| rs1000042094 | -- | 33,404,450(+) | AATGA(A/G)GACTC | intron-variant, nc-transcript-variant, downstream-variant-500B | |
| rs1000069396 | -- | 33,317,054(+) | ATGCT(A/G)TCACG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759138 | CNV | gain | 17122850 |
| esv3595794 | CNV | loss | 21293372 |
| nsv1001132 | CNV | gain | 25217958 |
| nsv10258 | CNV | loss | 18304495 |
| nsv1139102 | CNV | deletion | 24896259 |
| nsv477267 | CNV | novel sequence insertion | 20440878 |
| nsv522292 | CNV | loss | 19592680 |
| nsv525895 | CNV | gain | 19592680 |
| nsv822052 | CNV | loss | 20364138 |
| nsv834653 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.98;
20.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL2 Gene
Disorders for FBXL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatitis c virus |
|
|
Search FBXL2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FBXL2
No data available for UniProtKB/Swiss-Prot and Genatlas for FBXL2 Gene
Publications for FBXL2 Gene
- Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
- FBXL2- and PTPL1-mediated degradation of p110-free p85I^ regulatory subunit controls the PI(3)K signallingA cascade. (PMID: 23604317) Kuchay S. … Pagano M. (Nat. Cell Biol. 2013) 3 4 64
- F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest. (PMID: 22020328) Chen B.B. … Mallampalli R.K. (Oncogene 2012) 3 4 64
- F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. (PMID: 22323446) Chen B.B. … Mallampalli R.K. (Blood 2012) 3 4 64
- Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. (PMID: 15893726) Wang C. … Ye J. (Mol. Cell 2005) 3 4 64
Products for FBXL2 Gene
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- Plasmid Preparation
- GenScript Custom Peptide Services for FBXL2
- Sino Biological Human cDNA Clone for FBXL2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for FBXL2
- Novus Biologicals proteins and lysates for FBXL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for FBXL2
- Abcam proteins for FBXL2
- Search for Assays for FBXL2 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- antibodies-online Antibodies for FBXL2: See all 39
- antibodies-online Kits for FBXL2: See all 21
- antibodies-online Proteins for FBXL2: See all 7
- Search antibodies-online for peptides
- GeneTex FBXL2 antibody for FBXL2
- Search GeneTex for Proteins for FBXL2
- ViGene Biosciences adenoviral particle packaged cDNA for FBXL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for FBXL2 gene
- Search ViGene Biosciences for FBXL2
- Horizon Cell Lines for FBXL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for FBXL2
- VectorBuilder custom plasmid, inducible vectors for FBXL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FBXL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer