FBXL19 Gene
protein-coding GIFtS: 47
GCID: GC16P030934
|
|
F-box and leucine-rich repeat protein 19
| |
Aliases
for FBXL19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 191 2 3 | | F-Box/LRR-Repeat Protein 192 | | Fbl191 2 | | Jumonji C Domain-Containing Histone Demethylase 1C2 | | JHDM1C1 2 | | FBL193 | | DKFZp434K04101 | | |
Export aliases for FBXL19 gene to outside databasesPrevious GC identifers: GC16P030970 GC16P030841 GC16P030843 GC16P028498 |
Summaries
for FBXL19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL19:
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to thetransmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to theregulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Nov 2012)
UniProtKB/Swiss-Prot: FXL19_HUMAN, Q6PCT2Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
|
Genomic Views
for FBXL19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL19 gene promoter:
NF-1 AP-4 CUTL1 STAT5A E47 CREB deltaCREB ARP-1 Hand1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2FBXL19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P030934: view genomic region
(about GC identifiers)
Start:
|
30,934,376 bp from pter |
End:
|
30,960,104 bp from pter |
Size:
|
25,729 bases |
Orientation:
|
plus strand |
|
Proteins
for FBXL19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXL19_HUMAN, Q6PCT2 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 19 Size: 694 amino acids; 75707 Da
Subunit: Directly interacts with SKP1 and CUL1 (By similarity)
Caution: It is uncertain whether Met-1 or Met-21 is the initiator
Sequence caution: Sequence=AAH59173.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC05410.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MT10 Q8N789 Q9NT14Alternative splicing: 3 isoforms: Q6PCT2-1 Q6PCT2-2 Q6PCT2-3 Explore the universe of human proteins at neXtProt for FBXL19: NX_Q6PCT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PCT2
FBXL19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001093254.2 NP_001258580.1
ENSEMBL proteins: ENSP00000455871 ENSP00000458033 ENSP00000339712 ENSP00000455529 ENSP00000454344 ENSP00000397913 ENSP00000455337 ENSP00000457199 ENSP00000369666
Human Recombinant Protein Products:
FBXL19 Antibody Products:
Assay Products for FBXL19: |
Protein
Domains /
Families
for FBXL19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL19 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6PCT2ProtoNet protein and cluster: Q6PCT2 UniProtKB/Swiss-Prot: FXL19_HUMAN, Q6PCT2Similarity: Contains 1 CXXC-type zinc fingerSimilarity: Contains 1 F-box domainSimilarity: Contains 6 LRR (leucine-rich) repeatsSimilarity: Contains 1 PHD-type zinc finger |
Function
for FBXL19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FXL19_HUMAN, Q6PCT2Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL19 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL19 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FBXL19 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FBXL19:
|
Pathways & Interactions
for FBXL19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL19
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for FBXL19 (Q6PCT23 ENSP000003696664) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for FBXL19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL19
Search CenterWatch for drugs/clinical trials and news about FBXL19 / FXL19
|
Transcripts
for FBXL19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL19 gene (3 alternative transcripts): NM_001099784.2 NM_001271651.1 NM_019085.1 Unigene Cluster for FBXL19: F-box and leucine-rich repeat protein 19 Hs.152149 [show with all ESTs]Unigene Representative Sequence: NM_0010997849 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000562798 ENST00000471231(uc002dzz.1) ENST00000338343 ENST00000562319
ENST00000565690 ENST00000427128 ENST00000566320 ENST00000565939 ENST00000380310(uc002eab.2 uc002eaa.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL19 (see all 3)
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AK127701.1 AK302669.1 AL137589.1 BC032391.1 BC048811.1 BC059173.1 NR_073401.1 4 DOTS entries: DT.40261115 DT.95110062 DT.70103185 DT.87011836 24/186 AceView cDNA sequences (see all 186): BU185173 AA862341 NM_019085 AI280701 CA412795 AL137589 BX111140 BM129511 BF002009 AW027088 BC059173 AI289104 AI216337 BI196649 BQ574949 CK819711 AW444819 C01878 AA423891 AK098777 BQ648716 BM680919 BM764400 BM556657
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL19 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for FBXL19
|
Expression
for FBXL19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGGGAGGG
About this image
See FBXL19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL19
SOURCE GeneReport for Unigene cluster: Hs.152149
SABiosciences Custom PCR Arrays for FBXL19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL19
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL19 |
Orthologs
for FBXL19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBXL19 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FBXL196 |
-- |
59(a) |
1 ↔ 1 |
GL343220.1(1819350-1833799) |
zebrafish
(Danio rerio) |
Actinopterygii |
kdm2bb6kdm2ba6 |
lysine (K)-specific demethylase 2Ba |
42(a)32(a) |
possible ortholog1 ↔ 1 |
10(43194428-43202258) 8(42291602-42314330) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Kdm26 |
Lysine (K)-specific demethylase 2 |
9(a) |
1 → many |
3R(4878240-4888967) |
ENSEMBL Gene Tree for FBXL19 (if available)
TreeFam Gene Tree for FBXL19 (if available) |
Paralogs
for FBXL19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXL19 gene
- PHF22 PHF82 KDM2A2 JHDM1D2 KDM2B2
4 SIMAP similar genes for FBXL19 using alignment to 8 protein entries: FXL19_HUMAN (see all proteins):CXXC1 KDM2A kdm2a KDM2B
FBXL19 for paralogs About GeneDecksing
|
Genomic Variants
for FBXL19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL19 (30934376 - 30960104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FBXL19
2 CNVs: 4942 4941 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL19 |
|
Disorders
/ Diseases
for FBXL19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXL19 for disorders About GeneDecksing
OMIM gene information: 609085
OMIM disorders: --
2  diseases for FBXL19: About MalaCardspsoriatic arthritis arthritis
1 disease from the University of Copenhagen DISEASES database for FBXL19:Psoriatic arthritis Human Genome Epidemiology (HuGE) Navigator: FBXL19 (1 document)
Export disorders for FBXL19 gene to outside databases
|
Publications
for FBXL19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL19 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with FBXL19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- F-box protein FBXL19-mediated ubiquitination and degra dation of the receptor for IL-33 limits pulmonary inflammation. (PubMed id 22660580)1 Zhao J....Zhao Y. (2012)
- The Genetics of Psoriasis and Psoriatic Arthritis. (PubMed id 22274791)1 Chandran V. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Genome-wide association analysis identifies three pso riasis susceptibility loci. (PubMed id 20953189)1 Stuart P.E....Elder J.T. (2010)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Identification and characterization of FBXL19 gene in silico. (PubMed id 15547684)1 Katoh M. and Katoh M. (2004)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
|
External Searches for FBXL19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL19 gene:
Search GeneIP for patents involving FBXL19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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