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Aliases for FBXL19 Gene

Aliases for FBXL19 Gene

  • F-Box And Leucine Rich Repeat Protein 19 2 3 5
  • Jumonji C Domain-Containing Histone Demethylase 1C 2 3
  • Fbl19 3 4
  • F-Box And Leucine-Rich Repeat Protein 19 4
  • F-Box/LRR-Repeat Protein 19 3
  • CXXC11 3
  • JHDM1C 3

External Ids for FBXL19 Gene

Previous GeneCards Identifiers for FBXL19 Gene

  • GC16P030970
  • GC16P030841
  • GC16P030843
  • GC16P028498

Summaries for FBXL19 Gene

Entrez Gene Summary for FBXL19 Gene

  • This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FBXL19 Gene

FBXL19 (F-Box And Leucine Rich Repeat Protein 19) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is KDM2B.

UniProtKB/Swiss-Prot for FBXL19 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL19 Gene

Genomics for FBXL19 Gene

Regulatory Elements for FBXL19 Gene

Enhancers for FBXL19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030393 1.2 ENCODE 6 -527.9 -527929 2.9 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 SLC30A9 ZNF416 ZNF143 BCL7C SMG1P2 ENSG00000260304 ZNF764 ZNF785 TBC1D10B ENSG00000199787 DCTPP1 CD2BP2 MYLPF
GH16G030916 0.7 FANTOM5 0.4 -6.5 -6543 0.0 ZBTB11 NR2F1 NRF1 BHLHE40 ZBTB7A POLR2A IKZF1 ZNF143 NR2C1 ZBTB33 PIR60794 FBXL19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL19 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085265 145 3201 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21

Genomic Location for FBXL19 Gene

Chromosome:
16
Start:
30,923,055 bp from pter
End:
30,948,783 bp from pter
Size:
25,729 bases
Orientation:
Plus strand

Genomic View for FBXL19 Gene

Genes around FBXL19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL19 Gene

Proteins for FBXL19 Gene

  • Protein details for FBXL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCT2-FXL19_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 19
    Protein Accession:
    Q6PCT2
    Secondary Accessions:
    • A8MT10
    • Q8N789
    • Q9NT14

    Protein attributes for FBXL19 Gene

    Size:
    694 amino acids
    Molecular mass:
    75707 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH59173.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05410.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL19 Gene

Post-translational modifications for FBXL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL19 Gene

Domains & Families for FBXL19 Gene

Suggested Antigen Peptide Sequences for FBXL19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL19: view

No data available for UniProtKB/Swiss-Prot for FBXL19 Gene

Function for FBXL19 Gene

Molecular function for FBXL19 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 22660580
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FBXL19: view
genes like me logo Genes that share phenotypes with FBXL19: view

Animal Models for FBXL19 Gene

MGI Knock Outs for FBXL19:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL19 Gene

Localization for FBXL19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL19 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FBXL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 22660580
genes like me logo Genes that share ontologies with FBXL19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL19 Gene

Pathways & Interactions for FBXL19 Gene

genes like me logo Genes that share pathways with FBXL19: view

Gene Ontology (GO) - Biological Process for FBXL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 22660580
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL19: view

No data available for SIGNOR curated interactions for FBXL19 Gene

Drugs & Compounds for FBXL19 Gene

(1) Drugs for FBXL19 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with FBXL19: view

Transcripts for FBXL19 Gene

Unigene Clusters for FBXL19 Gene

F-box and leucine-rich repeat protein 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for FBXL19 Gene

GeneLoc Exon Structure for
FBXL19
ECgene alternative splicing isoforms for
FBXL19

Expression for FBXL19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL19 Gene

Protein differential expression in normal tissues from HIPED for FBXL19 Gene

This gene is overexpressed in Heart (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL19 Gene



Protein tissue co-expression partners for FBXL19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL19 Gene:

FBXL19

SOURCE GeneReport for Unigene cluster for FBXL19 Gene:

Hs.152149

Evidence on tissue expression from TISSUES for FBXL19 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with FBXL19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL19 Gene

Orthologs for FBXL19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL19 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL19 34 35
  • 94.38 (n)
cow
(Bos Taurus)
Mammalia FBXL19 34 35
  • 93.5 (n)
mouse
(Mus musculus)
Mammalia Fbxl19 34 16 35
  • 89.66 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL19 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL19 35
  • 2 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL19 35
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:158376 34
  • 64.44 (n)
FBXL19 35
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kdm2 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea jhdm-1 35
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JHD1 35
  • 1 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for FBXL19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FBXL19 Gene

ENSEMBL:
Gene Tree for FBXL19 (if available)
TreeFam:
Gene Tree for FBXL19 (if available)

Paralogs for FBXL19 Gene

Paralogs for FBXL19 Gene

(3) SIMAP similar genes for FBXL19 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FBXL19: view

Variants for FBXL19 Gene

Sequence variations from dbSNP and Humsavar for FBXL19 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000044858 -- 30,928,291(+) AGATG(A/G)AGCAT intron-variant
rs1000077830 -- 30,935,999(+) GCAGT(C/G)CTGTT intron-variant
rs1000380719 -- 30,943,169(+) CAGTC(C/G)CCTGA intron-variant
rs1000474124 -- 30,931,062(+) GCCCC(-/T)GCCCT intron-variant
rs1000489874 -- 30,939,111(+) CTGTC(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL19 Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
esv3373106 CNV insertion 20981092
esv3638389 CNV loss 21293372
nsv1070344 CNV deletion 25765185
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781
nsv833189 CNV loss 17160897
nsv953802 CNV deletion 24416366

Variation tolerance for FBXL19 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.53; 88.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL19 Gene

Human Gene Mutation Database (HGMD)
FBXL19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL19 Gene

Disorders for FBXL19 Gene

Relevant External Links for FBXL19

Genetic Association Database (GAD)
FBXL19
Human Genome Epidemiology (HuGE) Navigator
FBXL19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL19

No disorders were found for FBXL19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL19 Gene

Publications for FBXL19 Gene

  1. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart P.E. … Elder J.T. (Nat. Genet. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FBXL19 Gene

Sources for FBXL19 Gene

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