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Aliases for FBXL19 Gene

Aliases for FBXL19 Gene

  • F-Box And Leucine-Rich Repeat Protein 19 2 3 4
  • Jumonji C Domain-Containing Histone Demethylase 1C 2 3
  • Fbl19 3 4
  • CXXC11 3
  • JHDM1C 3

External Ids for FBXL19 Gene

Previous GeneCards Identifiers for FBXL19 Gene

  • GC16P030970
  • GC16P030841
  • GC16P030843
  • GC16P028498

Summaries for FBXL19 Gene

Entrez Gene Summary for FBXL19 Gene

  • This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FBXL19 Gene

FBXL19 (F-Box And Leucine-Rich Repeat Protein 19) is a Protein Coding gene. An important paralog of this gene is KDM2B.

UniProtKB/Swiss-Prot for FBXL19 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL19 Gene

Genomics for FBXL19 Gene

Regulatory Elements for FBXL19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL19 Gene

Chromosome:
16
Start:
30,923,055 bp from pter
End:
30,948,783 bp from pter
Size:
25,729 bases
Orientation:
Plus strand

Genomic View for FBXL19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL19 Gene

Proteins for FBXL19 Gene

  • Protein details for FBXL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCT2-FXL19_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 19
    Protein Accession:
    Q6PCT2
    Secondary Accessions:
    • A8MT10
    • Q8N789
    • Q9NT14

    Protein attributes for FBXL19 Gene

    Size:
    694 amino acids
    Molecular mass:
    75707 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=AAH59173.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC05410.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL19 Gene

Proteomics data for FBXL19 Gene at MOPED

Post-translational modifications for FBXL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL19 Gene

Domains & Families for FBXL19 Gene

Suggested Antigen Peptide Sequences for FBXL19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCT2

UniProtKB/Swiss-Prot:

FXL19_HUMAN :
  • Contains 1 F-box domain.
  • Contains 1 CXXC-type zinc finger.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 1 CXXC-type zinc finger.
  • Contains 6 LRR (leucine-rich) repeats.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with FBXL19: view

Function for FBXL19 Gene

Molecular function for FBXL19 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 22660580
GO:0008270 zinc ion binding IEA --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with FBXL19: view

Phenotypes for FBXL19 Gene

genes like me logo Genes that share phenotypes with FBXL19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL19 Gene

Localization for FBXL19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL19 Gene COMPARTMENTS Subcellular localization image for FBXL19 gene
Compartment Confidence
cytoskeleton 3
extracellular 1

Gene Ontology (GO) - Cellular Components for FBXL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0019005 SCF ubiquitin ligase complex IDA 22660580
genes like me logo Genes that share ontologies with FBXL19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL19 Gene

Pathways & Interactions for FBXL19 Gene

SuperPathways for FBXL19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 22660580
genes like me logo Genes that share ontologies with FBXL19: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL19 Gene

Drugs & Compounds for FBXL19 Gene

No Compound Related Data Available

Transcripts for FBXL19 Gene

Unigene Clusters for FBXL19 Gene

F-box and leucine-rich repeat protein 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for FBXL19 Gene

GeneLoc Exon Structure for
FBXL19
ECgene alternative splicing isoforms for
FBXL19

Expression for FBXL19 Gene

mRNA expression in normal human tissues for FBXL19 Gene

Protein differential expression in normal tissues from HIPED for FBXL19 Gene

This gene is overexpressed in Heart (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL19 Gene



SOURCE GeneReport for Unigene cluster for FBXL19 Gene Hs.152149

genes like me logo Genes that share expression patterns with FBXL19: view

Protein tissue co-expression partners for FBXL19 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL19 Gene

Orthologs for FBXL19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FBXL19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXL19 35
  • 93.5 (n)
  • 99.28 (a)
FBXL19 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL19 35
  • 94.38 (n)
  • 99.28 (a)
FBXL19 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl19 35
  • 89.66 (n)
  • 97.48 (a)
Fbxl19 16
Fbxl19 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL19 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL19 36
  • 2 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL19 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL19 36
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:158376 35
  • 64.44 (n)
  • 61.73 (a)
FBXL19 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kdm2 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea jhdm-1 36
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JHD1 36
  • 1 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for FBXL19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FBXL19 Gene

ENSEMBL:
Gene Tree for FBXL19 (if available)
TreeFam:
Gene Tree for FBXL19 (if available)

Paralogs for FBXL19 Gene

Paralogs for FBXL19 Gene

(3) SIMAP similar genes for FBXL19 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FBXL19: view

Variants for FBXL19 Gene

Sequence variations from dbSNP and Humsavar for FBXL19 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1458202 -- 30,941,881(+) TAAAC(A/G)AGGCT intron-variant
rs4405566 -- 30,941,853(-) CCCCC(C/G/T)ACTCT intron-variant
rs4889514 -- 30,931,775(+) AGGTT(A/G)GAGTG intron-variant
rs4889515 -- 30,932,263(+) CCTGT(C/T)AGGCC intron-variant
rs4889571 -- 30,937,726(+) TTGGC(A/G)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL19 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
nsv905733 CNV Loss 21882294
nsv833189 CNV Loss 17160897
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
dgv2671n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv905738 CNV Loss 21882294

Variation tolerance for FBXL19 Gene

Residual Variation Intolerance Score: 31.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.53; 88.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL19 Gene

HapMap Linkage Disequilibrium report
FBXL19
Human Gene Mutation Database (HGMD)
FBXL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL19 Gene

Disorders for FBXL19 Gene

Relevant External Links for FBXL19

Genetic Association Database (GAD)
FBXL19
Human Genome Epidemiology (HuGE) Navigator
FBXL19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL19
genes like me logo Genes that share disorders with FBXL19: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL19 Gene

Publications for FBXL19 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. F-box protein complex FBXL19 regulates TGFI^1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation. (PMID: 24684802) Dong S. … Zhao Y. (Mol. Cancer 2014) 67
  3. The genetics of psoriasis and psoriatic arthritis. (PMID: 22274791) Chandran V. (Clin Rev Allergy Immunol 2013) 67
  4. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 67
  5. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. (PMID: 22660580) Zhao J. … Zhao Y. (Nat. Immunol. 2012) 67

Products for FBXL19 Gene

Sources for FBXL19 Gene

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