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Aliases for FBXL18 Gene

Aliases for FBXL18 Gene

  • F-Box And Leucine-Rich Repeat Protein 18 2 3 4
  • Fbl18 3 4 6
  • F-Box/LRR-Repeat Protein 18 3

External Ids for FBXL18 Gene

Previous GeneCards Identifiers for FBXL18 Gene

  • GC07M005217
  • GC07M005244
  • GC07M005437
  • GC07M005428

Summaries for FBXL18 Gene

Entrez Gene Summary for FBXL18 Gene

  • Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL18 Gene

FBXL18 (F-Box And Leucine-Rich Repeat Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL18 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL18 Gene

Genomics for FBXL18 Gene

Regulatory Elements for FBXL18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL18 Gene

Start:
5,431,335 bp from pter
End:
5,513,798 bp from pter
Size:
82,464 bases
Orientation:
Minus strand

Genomic View for FBXL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL18 Gene

Proteins for FBXL18 Gene

  • Protein details for FBXL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ME1-FXL18_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 18
    Protein Accession:
    Q96ME1
    Secondary Accessions:
    • Q9BR90
    • Q9BTC7
    • Q9HAK7

    Protein attributes for FBXL18 Gene

    Size:
    805 amino acids
    Molecular mass:
    88341 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=BAB13838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL18 Gene

Proteomics data for FBXL18 Gene at MOPED

Post-translational modifications for FBXL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL18 Gene

No data available for DME Specific Peptides for FBXL18 Gene

Domains for FBXL18 Gene

Gene Families for FBXL18 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ME1

UniProtKB/Swiss-Prot:

FXL18_HUMAN :
  • Q96ME1
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL18: view

Function for FBXL18 Gene

Molecular function for FBXL18 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL18: view

Phenotypes for FBXL18 Gene

GenomeRNAi human phenotypes for FBXL18:
genes like me logo Genes that share phenotypes with FBXL18: view

Animal Model Products

CRISPR Products

miRNA for FBXL18 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXL18 Gene

Localization for FBXL18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL18 Gene COMPARTMENTS Subcellular localization image for FBXL18 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL18 Gene

Pathways for FBXL18 Gene

SuperPathways for FBXL18 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FBXL18 Gene

None

No data available for Pathways by source for FBXL18 Gene

Transcripts for FBXL18 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL18

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FBXL18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL18 Gene

No ASD Table

Relevant External Links for FBXL18 Gene

GeneLoc Exon Structure for
FBXL18
ECgene alternative splicing isoforms for
FBXL18

Expression for FBXL18 Gene

mRNA expression in normal human tissues for FBXL18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL18 Gene

SOURCE GeneReport for Unigene cluster for FBXL18 Gene Hs.623974

genes like me logo Genes that share expressions with FBXL18: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL18 Gene

Orthologs for FBXL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL18 35
  • 99.3 (n)
  • 99.58 (a)
FBXL18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL18 35
  • 86.22 (n)
  • 87.62 (a)
FBXL18 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL18 35
  • 88.24 (n)
  • 92.86 (a)
FBXL18 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl18 35
  • 86.73 (n)
  • 92.15 (a)
Fbxl18 16
Fbxl18 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL18 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL18 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl18 35
  • 86.85 (n)
  • 92.08 (a)
chicken
(Gallus gallus)
Aves FBXL18 35
  • 74.84 (n)
  • 79.01 (a)
FBXL18 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL18 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl18 35
  • 63.3 (n)
  • 67.11 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxl18 35
  • 58.31 (n)
  • 54.9 (a)
fbxl18 36
  • 50 (a)
OneToOne
Species with no ortholog for FBXL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL18 Gene

ENSEMBL:
Gene Tree for FBXL18 (if available)
TreeFam:
Gene Tree for FBXL18 (if available)

Paralogs for FBXL18 Gene

Selected SIMAP similar genes for FBXL18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL18: view

No data available for Paralogs for FBXL18 Gene

Variants for FBXL18 Gene

Sequence variations from dbSNP and Humsavar for FBXL18 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs852445 -- 5,515,117(-) ctcaa(A/G)ctcct upstream-variant-2KB
rs852446 -- 5,514,365(-) GGTCT(A/G)ATTAT upstream-variant-2KB
rs852447 -- 5,513,820(-) CGTGT(A/C)GGCGG upstream-variant-2KB
rs1123526 -- 5,513,898(+) TGCTG(G/T)AGTAC upstream-variant-2KB
rs1129360 -- 5,476,448(-) GAAGG(G/T)GTCGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXL18 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887391 CNV Loss 21882294
dgv7141n71 CNV Loss 21882294
dgv7142n71 CNV Loss 21882294
nsv887407 CNV Loss 21882294
nsv526194 CNV Gain 19592680
nsv830890 CNV Loss 17160897
nsv887409 CNV Loss 21882294
nsv517558 CNV Loss 19592680
nsv887410 CNV Loss 21882294
nsv887411 CNV Loss 21882294
nsv471304 CNV Loss 18288195
nsv887412 CNV Loss 21882294
nsv887413 CNV Loss 21882294
esv2671867 CNV Deletion 23128226
esv2733912 CNV Deletion 23290073
nsv823999 CNV Gain 20364138

Relevant External Links for FBXL18 Gene

HapMap Linkage Disequilibrium report
FBXL18
Human Gene Mutation Database (HGMD)
FBXL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL18 Gene

Disorders for FBXL18 Gene

Relevant External Links for FBXL18

Genetic Association Database (GAD)
FBXL18
genes like me logo Genes that share disorders with FBXL18: view

No data available for UniProtKB/Swiss-Prot for FBXL18 Gene

Publications for FBXL18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. (PMID: 18247557) Jones J. … Huang L. (J. Proteome Res. 2008) 3

Products for FBXL18 Gene

Sources for FBXL18 Gene

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