Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXL18 Gene

Aliases for FBXL18 Gene

  • F-Box And Leucine-Rich Repeat Protein 18 2 3 4 5
  • Fbl18 3 4

External Ids for FBXL18 Gene

Previous GeneCards Identifiers for FBXL18 Gene

  • GC07M005217
  • GC07M005244
  • GC07M005437
  • GC07M005428

Summaries for FBXL18 Gene

Entrez Gene Summary for FBXL18 Gene

  • The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]

GeneCards Summary for FBXL18 Gene

FBXL18 (F-Box And Leucine-Rich Repeat Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL18 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL18 Gene

Genomics for FBXL18 Gene

Regulatory Elements for FBXL18 Gene

Enhancers for FBXL18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXL18 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL18 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL18 Gene

Chromosome:
7
Start:
5,431,335 bp from pter
End:
5,513,805 bp from pter
Size:
82,471 bases
Orientation:
Minus strand

Genomic View for FBXL18 Gene

Genes around FBXL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL18 Gene

Proteins for FBXL18 Gene

  • Protein details for FBXL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ME1-FXL18_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 18
    Protein Accession:
    Q96ME1
    Secondary Accessions:
    • Q9BR90
    • Q9BTC7
    • Q9HAK7

    Protein attributes for FBXL18 Gene

    Size:
    805 amino acids
    Molecular mass:
    88341 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=BAB13838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL18 Gene

Proteomics data for FBXL18 Gene at MOPED

Post-translational modifications for FBXL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL18 Gene

No data available for DME Specific Peptides for FBXL18 Gene

Domains & Families for FBXL18 Gene

Gene Families for FBXL18 Gene

Protein Domains for FBXL18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ME1

UniProtKB/Swiss-Prot:

FXL18_HUMAN :
  • Contains 1 F-box domain.
  • Contains 12 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL18: view

Function for FBXL18 Gene

Molecular function for FBXL18 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXL18: view

Animal Model Products

CRISPR Products

miRNA for FBXL18 Gene

miRTarBase miRNAs that target FBXL18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL18 Gene

Localization for FBXL18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL18 Gene COMPARTMENTS Subcellular localization image for FBXL18 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL18 Gene

Pathways & Interactions for FBXL18 Gene

SuperPathways for FBXL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXL18 Gene

Drugs & Compounds for FBXL18 Gene

No Compound Related Data Available

Transcripts for FBXL18 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL18 Gene

No ASD Table

Relevant External Links for FBXL18 Gene

GeneLoc Exon Structure for
FBXL18
ECgene alternative splicing isoforms for
FBXL18

Expression for FBXL18 Gene

mRNA expression in normal human tissues for FBXL18 Gene

Protein differential expression in normal tissues from HIPED for FBXL18 Gene

This gene is overexpressed in Breast (27.2) and Frontal cortex (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL18 Gene



SOURCE GeneReport for Unigene cluster for FBXL18 Gene Hs.623974

genes like me logo Genes that share expression patterns with FBXL18: view

Protein tissue co-expression partners for FBXL18 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL18 Gene

Orthologs for FBXL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXL18 35
  • 86.22 (n)
  • 87.62 (a)
FBXL18 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL18 35
  • 88.24 (n)
  • 92.86 (a)
FBXL18 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl18 35
  • 86.73 (n)
  • 92.15 (a)
Fbxl18 16
Fbxl18 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL18 35
  • 99.3 (n)
  • 99.58 (a)
FBXL18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl18 35
  • 86.85 (n)
  • 92.08 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXL18 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL18 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL18 35
  • 74.84 (n)
  • 79.01 (a)
FBXL18 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL18 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl18 35
  • 63.3 (n)
  • 67.11 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxl18 35
  • 58.31 (n)
  • 54.9 (a)
fbxl18 36
  • 50 (a)
OneToOne
Species with no ortholog for FBXL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL18 Gene

ENSEMBL:
Gene Tree for FBXL18 (if available)
TreeFam:
Gene Tree for FBXL18 (if available)

Paralogs for FBXL18 Gene

(1) SIMAP similar genes for FBXL18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL18: view

No data available for Paralogs for FBXL18 Gene

Variants for FBXL18 Gene

Sequence variations from dbSNP and Humsavar for FBXL18 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs33941092 - 5,500,613(+) CCGAT(A/C)TTGAC reference, missense
rs6948909 -- 5,466,868(+) ATCTC(G/T)GGACA intron-variant
rs6952191 -- 5,485,632(+) gctag(C/G)catgg intron-variant
rs1129360 -- 5,476,448(-) GAAGG(G/T)GTCGG intron-variant, utr-variant-3-prime
rs6953642 -- 5,501,138(+) ACCAG(A/C)GTCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FBXL18 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887391 CNV Loss 21882294
dgv7141n71 CNV Loss 21882294
dgv7142n71 CNV Loss 21882294
nsv887407 CNV Loss 21882294
nsv526194 CNV Gain 19592680
nsv830890 CNV Loss 17160897
nsv887409 CNV Loss 21882294
nsv517558 CNV Loss 19592680
nsv887410 CNV Loss 21882294
nsv887411 CNV Loss 21882294
nsv471304 CNV Loss 18288195
nsv887412 CNV Loss 21882294
nsv887413 CNV Loss 21882294
esv2671867 CNV Deletion 23128226
esv2733912 CNV Deletion 23290073
nsv823999 CNV Gain 20364138

Variation tolerance for FBXL18 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL18 Gene

Human Gene Mutation Database (HGMD)
FBXL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL18 Gene

Disorders for FBXL18 Gene

Relevant External Links for FBXL18

Genetic Association Database (GAD)
FBXL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL18

No disorders were found for FBXL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL18 Gene

Publications for FBXL18 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. (PMID: 25654763) Liu Y. … Mallampalli R.K. (Cell Death Dis 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for FBXL18 Gene

Sources for FBXL18 Gene

Content