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Aliases for FBXL18 Gene

Aliases for FBXL18 Gene

  • F-Box And Leucine-Rich Repeat Protein 18 2 3 4
  • Fbl18 3 4

External Ids for FBXL18 Gene

Previous GeneCards Identifiers for FBXL18 Gene

  • GC07M005217
  • GC07M005244
  • GC07M005437
  • GC07M005428

Summaries for FBXL18 Gene

Entrez Gene Summary for FBXL18 Gene

  • Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL18 Gene

FBXL18 (F-Box And Leucine-Rich Repeat Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL18 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL18 Gene

Genomics for FBXL18 Gene

Regulatory Elements for FBXL18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL18 Gene

Chromosome:
7
Start:
5,431,335 bp from pter
End:
5,513,805 bp from pter
Size:
82,471 bases
Orientation:
Minus strand

Genomic View for FBXL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for FBXL18 Gene

Proteins for FBXL18 Gene

  • Protein details for FBXL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ME1-FXL18_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 18
    Protein Accession:
    Q96ME1
    Secondary Accessions:
    • Q9BR90
    • Q9BTC7
    • Q9HAK7

    Protein attributes for FBXL18 Gene

    Size:
    805 amino acids
    Molecular mass:
    88341 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=BAB13838.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL18 Gene

Proteomics data for FBXL18 Gene at MOPED

Post-translational modifications for FBXL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL18 Gene

No data available for DME Specific Peptides for FBXL18 Gene

Domains & Families for FBXL18 Gene

Gene Families for FBXL18 Gene

Protein Domains for FBXL18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ME1

UniProtKB/Swiss-Prot:

FXL18_HUMAN :
  • Contains 1 F-box domain.
  • Contains 12 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL18: view

Function for FBXL18 Gene

Molecular function for FBXL18 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with FBXL18: view
genes like me logo Genes that share phenotypes with FBXL18: view

Animal Model Products

CRISPR Products

miRNA for FBXL18 Gene

miRTarBase miRNAs that target FBXL18

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL18 Gene

Localization for FBXL18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL18 Gene COMPARTMENTS Subcellular localization image for FBXL18 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBXL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with FBXL18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL18 Gene

Pathways & Interactions for FBXL18 Gene

SuperPathways for FBXL18 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FBXL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with FBXL18: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL18 Gene

Drugs & Compounds for FBXL18 Gene

No Compound Related Data Available

Transcripts for FBXL18 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL18

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL18 Gene

No ASD Table

Relevant External Links for FBXL18 Gene

GeneLoc Exon Structure for
FBXL18
ECgene alternative splicing isoforms for
FBXL18

Expression for FBXL18 Gene

mRNA expression in normal human tissues for FBXL18 Gene

Protein differential expression in normal tissues from HIPED for FBXL18 Gene

This gene is overexpressed in Breast (27.2) and Frontal cortex (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL18 Gene



SOURCE GeneReport for Unigene cluster for FBXL18 Gene Hs.623974

genes like me logo Genes that share expression patterns with FBXL18: view

Protein tissue co-expression partners for FBXL18 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL18 Gene

Orthologs for FBXL18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXL18 35
  • 86.22 (n)
  • 87.62 (a)
FBXL18 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL18 35
  • 88.24 (n)
  • 92.86 (a)
FBXL18 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl18 35
  • 86.73 (n)
  • 92.15 (a)
Fbxl18 16
Fbxl18 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL18 35
  • 99.3 (n)
  • 99.58 (a)
FBXL18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl18 35
  • 86.85 (n)
  • 92.08 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXL18 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL18 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL18 35
  • 74.84 (n)
  • 79.01 (a)
FBXL18 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL18 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl18 35
  • 63.3 (n)
  • 67.11 (a)
zebrafish
(Danio rerio)
Actinopterygii fbxl18 35
  • 58.31 (n)
  • 54.9 (a)
fbxl18 36
  • 50 (a)
OneToOne
Species with no ortholog for FBXL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL18 Gene

ENSEMBL:
Gene Tree for FBXL18 (if available)
TreeFam:
Gene Tree for FBXL18 (if available)

Paralogs for FBXL18 Gene

(1) SIMAP similar genes for FBXL18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL18: view

No data available for Paralogs for FBXL18 Gene

Variants for FBXL18 Gene

Sequence variations from dbSNP and Humsavar for FBXL18 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1129360 -- 5,476,448(-) GAAGG(G/T)GTCGG utr-variant-3-prime, intron-variant
rs1860882 -- 5,505,901(-) ACAAC(A/G)ATAGT intron-variant
rs1860883 -- 5,505,796(-) AATGG(A/G)GTTTT intron-variant
rs2346232 -- 5,506,128(-) AACAC(C/G)CTTTG intron-variant
rs2346233 -- 5,506,045(-) CTACA(A/G)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL18 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887391 CNV Loss 21882294
dgv7141n71 CNV Loss 21882294
dgv7142n71 CNV Loss 21882294
nsv887407 CNV Loss 21882294
nsv526194 CNV Gain 19592680
nsv830890 CNV Loss 17160897
nsv887409 CNV Loss 21882294
nsv517558 CNV Loss 19592680
nsv887410 CNV Loss 21882294
nsv887411 CNV Loss 21882294
nsv471304 CNV Loss 18288195
nsv887412 CNV Loss 21882294
nsv887413 CNV Loss 21882294
esv2671867 CNV Deletion 23128226
esv2733912 CNV Deletion 23290073
nsv823999 CNV Gain 20364138

Variation tolerance for FBXL18 Gene

Residual Variation Intolerance Score: 21.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL18 Gene

HapMap Linkage Disequilibrium report
FBXL18
Human Gene Mutation Database (HGMD)
FBXL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL18 Gene

Disorders for FBXL18 Gene

Relevant External Links for FBXL18

Genetic Association Database (GAD)
FBXL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL18
genes like me logo Genes that share disorders with FBXL18: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL18 Gene

Publications for FBXL18 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. (PMID: 25654763) Liu Y. … Mallampalli R.K. (Cell Death Dis 2015) 67
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for FBXL18 Gene

Sources for FBXL18 Gene

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