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Aliases for FBXL17 Gene

Aliases for FBXL17 Gene

  • F-Box And Leucine-Rich Repeat Protein 17 2 3 4
  • F-Box Only Protein 13 2 3 4
  • FBXO13 3 4 6
  • Fbl17 3 4 6
  • Fbx13 3 4 6
  • F-Box/LRR-Repeat Protein 17 3

External Ids for FBXL17 Gene

Previous HGNC Symbols for FBXL17 Gene

  • FBXO13

Previous GeneCards Identifiers for FBXL17 Gene

  • GC05M107271
  • GC05M107223
  • GC05M102367

Summaries for FBXL17 Gene

Entrez Gene Summary for FBXL17 Gene

  • Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL17 Gene

FBXL17 (F-Box And Leucine-Rich Repeat Protein 17) is a Protein Coding gene. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL17 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL17 Gene

Genomics for FBXL17 Gene

Regulatory Elements for FBXL17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL17 Gene

107,859,033 bp from pter
108,382,564 bp from pter
523,532 bases
Minus strand

Genomic View for FBXL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL17 Gene

Proteins for FBXL17 Gene

  • Protein details for FBXL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 17
    Protein Accession:
    Secondary Accessions:
    • A1A4E3

    Protein attributes for FBXL17 Gene

    701 amino acids
    Molecular mass:
    75695 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL17 Gene


neXtProt entry for FBXL17 Gene

Proteomics data for FBXL17 Gene at MOPED

Post-translational modifications for FBXL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL17 Gene

No data available for DME Specific Peptides for FBXL17 Gene

Domains for FBXL17 Gene

Gene Families for FBXL17 Gene

Protein Domains for FBXL17 Gene


Suggested Antigen Peptide Sequences for FBXL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXL17: view

Function for FBXL17 Gene

Molecular function for FBXL17 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL17: view

Phenotypes for FBXL17 Gene

genes like me logo Genes that share phenotypes with FBXL17: view

Animal Model Products

CRISPR Products

miRNA for FBXL17 Gene

miRTarBase miRNAs that target FBXL17

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL17

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL17 Gene

Localization for FBXL17 Gene

Subcellular locations from

Jensen Localization Image for FBXL17 Gene COMPARTMENTS Subcellular localization image for FBXL17 gene
Compartment Confidence
peroxisome 2
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL17 Gene

Pathways for FBXL17 Gene

SuperPathways for FBXL17 Gene

No Data Available

Interacting Proteins for FBXL17 Gene

Gene Ontology (GO) - Biological Process for FBXL17 Gene


No data available for Pathways by source for FBXL17 Gene

Drugs for FBXL17 Gene

(1) PharmGKB related drug/compound annotations for FBXL17 Gene

Drug/compound Annotation
hydrochlorothiazide Clinical Annotation
genes like me logo Genes that share compounds with FBXL17: view

Transcripts for FBXL17 Gene

Unigene Clusters for FBXL17 Gene

F-box and leucine-rich repeat protein 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL17 Gene

No ASD Table

Relevant External Links for FBXL17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL17 Gene

mRNA expression in normal human tissues for FBXL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FBXL17 Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL17 Gene

SOURCE GeneReport for Unigene cluster for FBXL17 Gene Hs.657225

genes like me logo Genes that share expressions with FBXL17: view

Expression partners for FBXL17 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL17 Gene

Orthologs for FBXL17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL17 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FBXL17 35
  • 95.91 (n)
  • 99.47 (a)
-- 36
  • 96 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Fbxl17 35
  • 90.6 (n)
  • 92.81 (a)
Fbxl17 16
Fbxl17 36
  • 93 (a)
(Pan troglodytes)
Mammalia FBXL17 35
  • 99.57 (n)
  • 99.43 (a)
FBXL17 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxl17 35
  • 91.31 (n)
  • 97.36 (a)
(Bos Taurus)
Mammalia FBXL17 36
  • 98 (a)
(Monodelphis domestica)
Mammalia FBXL17 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 79 (a)
(Gallus gallus)
Aves FBXL17 35
  • 84.62 (n)
  • 76.92 (a)
FBXL17 36
  • 75 (a)
(Anolis carolinensis)
Reptilia FBXL17 36
  • 77 (a)
(Danio rerio)
Actinopterygii LOC795023 35
  • 59.44 (n)
  • 57.28 (a)
FBXL17 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for FBXL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL17 Gene

Gene Tree for FBXL17 (if available)
Gene Tree for FBXL17 (if available)

Paralogs for FBXL17 Gene

Paralogs for FBXL17 Gene

genes like me logo Genes that share paralogs with FBXL17: view

Variants for FBXL17 Gene

Sequence variations from dbSNP and Humsavar for FBXL17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs11253 -- 107,859,081(-) ATTTC(C/T)GTGAA utr-variant-3-prime
rs34383 -- 108,116,905(-) TTCTG(A/T)TTGTA intron-variant
rs34384 -- 108,119,269(-) ACAAC(C/T)TCAGG intron-variant
rs34385 -- 108,120,413(-) TTATC(G/T)GTGTC intron-variant
rs34386 -- 108,176,202(-) GAATA(C/T)GGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL17 Gene

Variant ID Type Subtype PubMed ID
nsv830440 CNV Gain 17160897
nsv518663 CNV Loss 19592680
esv22701 CNV Loss 19812545
esv2675178 CNV Deletion 23128226
nsv882682 CNV Loss 21882294
esv273469 CNV Insertion 20981092
nsv327830 CNV Loss 16902084
esv2670014 CNV Deletion 23128226
esv2528556 CNV Deletion 19546169
nsv830441 CNV Loss 17160897
nsv518369 CNV Loss 19592680
nsv882683 CNV Loss 21882294
esv2621797 CNV Deletion 19546169
nsv882684 CNV Loss 21882294
nsv830442 CNV Gain 17160897
esv2730581 CNV Deletion 23290073
dgv6290n71 CNV Loss 21882294
nsv882686 CNV Loss 21882294
esv998139 CNV Insertion 20482838
nsv4950 CNV Loss 18451855
nsv882689 CNV Gain 21882294
nsv499245 CNV Loss 21111241
esv2166597 CNV Deletion 18987734

Relevant External Links for FBXL17 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL17 Gene

Disorders for FBXL17 Gene

Relevant External Links for FBXL17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FBXL17 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FBXL17 Gene

Publications for FBXL17 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Systematic analysis and nomenclature of mammalian F-box proteins. (PMID: 15520277) Jin J. … Harper J.W. (Genes Dev. 2004) 3
  4. Identification of F-box/LLR-repeated protein 17 as potential useful biomarker for breast cancer therapy. (PMID: 18820369) Xiao G.G. … Yen Y. (Cancer Genomics Proteomics 2008) 3
  5. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PMID: 20200978) Ichikawa S. … Econs M.J. (J. Bone Miner. Res. 2010) 3

Products for FBXL17 Gene

Sources for FBXL17 Gene

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