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Aliases for FBXL17 Gene

Aliases for FBXL17 Gene

  • F-Box And Leucine-Rich Repeat Protein 17 2 3 4 5
  • F-Box Only Protein 13 2 3 4
  • FBXO13 3 4
  • Fbl17 3 4
  • Fbx13 3 4

External Ids for FBXL17 Gene

Previous HGNC Symbols for FBXL17 Gene

  • FBXO13

Previous GeneCards Identifiers for FBXL17 Gene

  • GC05M107271
  • GC05M107223
  • GC05M102367

Summaries for FBXL17 Gene

Entrez Gene Summary for FBXL17 Gene

  • Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL17 Gene

FBXL17 (F-Box And Leucine-Rich Repeat Protein 17) is a Protein Coding gene. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL17 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL17 Gene

Genomics for FBXL17 Gene

Regulatory Elements for FBXL17 Gene

Enhancers for FBXL17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXL17 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL17 Gene

107,859,033 bp from pter
108,382,098 bp from pter
523,066 bases
Minus strand

Genomic View for FBXL17 Gene

Genes around FBXL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL17 Gene

Proteins for FBXL17 Gene

  • Protein details for FBXL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 17
    Protein Accession:
    Secondary Accessions:
    • A1A4E3

    Protein attributes for FBXL17 Gene

    701 amino acids
    Molecular mass:
    75695 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL17 Gene


neXtProt entry for FBXL17 Gene

Proteomics data for FBXL17 Gene at MOPED

Post-translational modifications for FBXL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL17 Gene

No data available for DME Specific Peptides for FBXL17 Gene

Domains & Families for FBXL17 Gene

Gene Families for FBXL17 Gene

Protein Domains for FBXL17 Gene


Suggested Antigen Peptide Sequences for FBXL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 1 F-box domain.
genes like me logo Genes that share domains with FBXL17: view

Function for FBXL17 Gene

Molecular function for FBXL17 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXL17: view

Animal Model Products

CRISPR Products

miRNA for FBXL17 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL17 Gene

Localization for FBXL17 Gene

Subcellular locations from

Jensen Localization Image for FBXL17 Gene COMPARTMENTS Subcellular localization image for FBXL17 gene
Compartment Confidence
nucleus 2
peroxisome 2
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL17 Gene

Pathways & Interactions for FBXL17 Gene

SuperPathways for FBXL17 Gene

No Data Available

Interacting Proteins for FBXL17 Gene

Gene Ontology (GO) - Biological Process for FBXL17 Gene


No data available for Pathways by source and SIGNOR curated interactions for FBXL17 Gene

Drugs & Compounds for FBXL17 Gene

(1) Drugs for FBXL17 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 396
genes like me logo Genes that share compounds with FBXL17: view

Transcripts for FBXL17 Gene

Unigene Clusters for FBXL17 Gene

F-box and leucine-rich repeat protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL17 Gene

No ASD Table

Relevant External Links for FBXL17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL17 Gene

mRNA expression in normal human tissues for FBXL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL17 Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL17 Gene

SOURCE GeneReport for Unigene cluster for FBXL17 Gene Hs.657225

genes like me logo Genes that share expression patterns with FBXL17: view

Protein tissue co-expression partners for FBXL17 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL17 Gene

Orthologs for FBXL17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL17 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FBXL17 35
  • 95.91 (n)
  • 99.47 (a)
-- 36
  • 96 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Fbxl17 35
  • 90.6 (n)
  • 92.81 (a)
Fbxl17 16
Fbxl17 36
  • 93 (a)
(Pan troglodytes)
Mammalia FBXL17 35
  • 99.57 (n)
  • 99.43 (a)
FBXL17 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fbxl17 35
  • 91.31 (n)
  • 97.36 (a)
(Bos Taurus)
Mammalia FBXL17 36
  • 98 (a)
(Monodelphis domestica)
Mammalia FBXL17 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 79 (a)
(Gallus gallus)
Aves FBXL17 35
  • 84.62 (n)
  • 76.92 (a)
FBXL17 36
  • 75 (a)
(Anolis carolinensis)
Reptilia FBXL17 36
  • 77 (a)
(Danio rerio)
Actinopterygii LOC795023 35
  • 59.44 (n)
  • 57.28 (a)
FBXL17 36
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for FBXL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL17 Gene

Gene Tree for FBXL17 (if available)
Gene Tree for FBXL17 (if available)

Paralogs for FBXL17 Gene

Paralogs for FBXL17 Gene

genes like me logo Genes that share paralogs with FBXL17: view

Variants for FBXL17 Gene

Sequence variations from dbSNP and Humsavar for FBXL17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs715638 -- 108,180,895(-) ATCAT(A/G/T)TATTT intron-variant
rs723396 -- 108,012,133(+) ATTAA(C/T)TAAAA intron-variant
rs723397 -- 108,012,342(+) AGCTA(C/T)AGAAC intron-variant
rs723398 -- 108,012,327(+) CAATC(A/T)CCCCC intron-variant
rs11253 -- 107,859,081(-) ATTTC(C/T)GTGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXL17 Gene

Variant ID Type Subtype PubMed ID
nsv830440 CNV Gain 17160897
nsv518663 CNV Loss 19592680
esv22701 CNV Loss 19812545
esv2675178 CNV Deletion 23128226
nsv882682 CNV Loss 21882294
esv273469 CNV Insertion 20981092
nsv327830 CNV Loss 16902084
esv2670014 CNV Deletion 23128226
esv2528556 CNV Deletion 19546169
nsv830441 CNV Loss 17160897
nsv518369 CNV Loss 19592680
nsv882683 CNV Loss 21882294
esv2621797 CNV Deletion 19546169
nsv882684 CNV Loss 21882294
nsv830442 CNV Gain 17160897
esv2730581 CNV Deletion 23290073
dgv6290n71 CNV Loss 21882294
nsv882686 CNV Loss 21882294
esv998139 CNV Insertion 20482838
nsv4950 CNV Loss 18451855
nsv882689 CNV Gain 21882294
nsv499245 CNV Loss 21111241
esv2166597 CNV Deletion 18987734

Variation tolerance for FBXL17 Gene

Gene Damage Index Score: 3.42; 54.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL17 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL17 Gene

Disorders for FBXL17 Gene

Relevant External Links for FBXL17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL17 Gene

Publications for FBXL17 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3
  5. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. (PMID: 24322204) Winham S.J. … Biernacka J.M. (Mol. Psychiatry 2013) 3

Products for FBXL17 Gene

Sources for FBXL17 Gene