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Aliases for FBXL17 Gene

Aliases for FBXL17 Gene

  • F-Box And Leucine Rich Repeat Protein 17 2 3 5
  • F-Box Only Protein 13 2 3 4
  • FBXO13 3 4
  • Fbl17 3 4
  • Fbx13 3 4
  • F-Box And Leucine-Rich Repeat Protein 17 4
  • F-Box/LRR-Repeat Protein 17 3

External Ids for FBXL17 Gene

Previous HGNC Symbols for FBXL17 Gene

  • FBXO13

Previous GeneCards Identifiers for FBXL17 Gene

  • GC05M107271
  • GC05M107223
  • GC05M102367

Summaries for FBXL17 Gene

Entrez Gene Summary for FBXL17 Gene

  • Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL17 Gene

FBXL17 (F-Box And Leucine Rich Repeat Protein 17) is a Protein Coding gene. Diseases associated with FBXL17 include Basal Cell Nevus Syndrome. An important paralog of this gene is FBXL7.

UniProtKB/Swiss-Prot for FBXL17 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXL17 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL17 Gene

Genomics for FBXL17 Gene

Regulatory Elements for FBXL17 Gene

Enhancers for FBXL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H107964 1 VISTA 9.4 +416.4 416380 3.1 TBL1XR1 BACH1 BMI1 ATF7 ZSCAN29 IKZF2 EZH2 NR2F1 TRIM22 DPF2 FBXL17 GC05P107897 GC05P108054
GH05H108379 1.4 ENCODE dbSUPER 5 +0.2 231 4.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FER FBXL17 GC05P108054
GH05H107668 1.3 ENCODE dbSUPER 4.3 +711.0 711047 5.8 PKNOX1 SIN3A FEZF1 ZNF2 ZNF143 DEK SP3 REST ZNF610 GLIS1 FBXL17 EFNA5 GC05P107680
GH05H108077 0.5 ENCODE dbSUPER 10.3 +302.7 302657 4.2 FBXL17 GC05P108054
GH05H108560 0.9 Ensembl ENCODE 5.3 -179.2 -179231 2.4 ZBTB21 GFI1B ZNF843 ATF2 HIC1 PRDM6 ZNF692 GLIS1 POU5F1 FOS FBXL17 GC05P108543 RPS20P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL17 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000184969 598 3401 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Locations for FBXL17 Gene

Genomic Locations for FBXL17 Gene
chr5:107,859,033-108,382,098
(GRCh38/hg38)
Size:
523,066 bases
Orientation:
Minus strand
chr5:107,194,734-107,717,799
(GRCh37/hg19)

Genomic View for FBXL17 Gene

Genes around FBXL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL17 Gene

Proteins for FBXL17 Gene

  • Protein details for FBXL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UF56-FXL17_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 17
    Protein Accession:
    Q9UF56
    Secondary Accessions:
    • A1A4E3

    Protein attributes for FBXL17 Gene

    Size:
    701 amino acids
    Molecular mass:
    75695 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL17 Gene

Post-translational modifications for FBXL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL17 Gene

Domains & Families for FBXL17 Gene

Gene Families for FBXL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FBXL17 Gene

Suggested Antigen Peptide Sequences for FBXL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL17: view

No data available for UniProtKB/Swiss-Prot for FBXL17 Gene

Function for FBXL17 Gene

Molecular function for FBXL17 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXL17 Gene

genes like me logo Genes that share phenotypes with FBXL17: view

miRNA for FBXL17 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL17 Gene

Localization for FBXL17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL17 gene
Compartment Confidence
plasma membrane 2
peroxisome 2
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL17 Gene

Pathways & Interactions for FBXL17 Gene

SuperPathways for FBXL17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBXL17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXL17 Gene

Drugs & Compounds for FBXL17 Gene

(1) Drugs for FBXL17 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 421
genes like me logo Genes that share compounds with FBXL17: view

Transcripts for FBXL17 Gene

Unigene Clusters for FBXL17 Gene

F-box and leucine-rich repeat protein 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL17 Gene

No ASD Table

Relevant External Links for FBXL17 Gene

GeneLoc Exon Structure for
FBXL17
ECgene alternative splicing isoforms for
FBXL17

Expression for FBXL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBXL17 Gene

This gene is overexpressed in Plasma (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL17 Gene



Protein tissue co-expression partners for FBXL17 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL17 Gene:

FBXL17

SOURCE GeneReport for Unigene cluster for FBXL17 Gene:

Hs.657225

Evidence on tissue expression from TISSUES for FBXL17 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with FBXL17: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL17 Gene

Orthologs for FBXL17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL17 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia FBXL17 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
OneToMany
FBXL17 33
  • 95.91 (n)
-- 34
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fbxl17 33
  • 91.31 (n)
mouse
(Mus musculus)
Mammalia Fbxl17 33 16 34
  • 90.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FBXL17 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL17 33 34
  • 84.62 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL17 34
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC795023 33
  • 59.44 (n)
FBXL17 34
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToOne
Species where no ortholog for FBXL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL17 Gene

ENSEMBL:
Gene Tree for FBXL17 (if available)
TreeFam:
Gene Tree for FBXL17 (if available)

Paralogs for FBXL17 Gene

Paralogs for FBXL17 Gene

genes like me logo Genes that share paralogs with FBXL17: view

Variants for FBXL17 Gene

Sequence variations from dbSNP and Humsavar for FBXL17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000003831 -- 107,935,304(+) CTGCT(A/G)TGCCT intron-variant
rs1000011838 -- 108,291,366(+) TCATC(A/T)CGTGC intron-variant
rs1000015600 -- 108,306,842(+) CTTGT(A/G)AGCAC intron-variant
rs1000015632 -- 108,370,898(+) AAAAG(C/T)TAGTA intron-variant
rs1000026682 -- 108,245,817(+) TGTAC(A/G)ACATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL17 Gene

Variant ID Type Subtype PubMed ID
nsv830442 CNV gain 17160897
nsv830441 CNV loss 17160897
nsv830440 CNV gain 17160897
nsv599337 CNV loss 21841781
nsv599336 CNV loss 21841781
nsv599335 CNV loss 21841781
nsv518663 CNV loss 19592680
nsv518369 CNV loss 19592680
nsv499245 CNV loss 21111241
nsv4950 CNV deletion 18451855
nsv472808 CNV novel sequence insertion 20440878
nsv471924 CNV novel sequence insertion 20440878
nsv327830 CNV deletion 16902084
nsv1128180 CNV deletion 24896259
nsv1029650 CNV loss 25217958
nsv1017067 CNV loss 25217958
esv998139 CNV insertion 20482838
esv3606206 CNV loss 21293372
esv3606205 CNV loss 21293372
esv3606203 CNV loss 21293372
esv3606201 CNV loss 21293372
esv3575869 CNV gain 25503493
esv3570332 CNV loss 25503493
esv3566421 CNV deletion 23714750
esv3440391 CNV insertion 20981092
esv3309196 CNV mobile element insertion 20981092
esv2730581 CNV deletion 23290073
esv2675178 CNV deletion 23128226
esv2670014 CNV deletion 23128226
esv2621797 CNV deletion 19546169
esv2528556 CNV deletion 19546169
esv22701 CNV loss 19812545
esv2166597 CNV deletion 18987734
dgv5776n100 CNV loss 25217958
dgv5775n100 CNV loss 25217958

Variation tolerance for FBXL17 Gene

Gene Damage Index Score: 3.42; 54.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL17 Gene

Human Gene Mutation Database (HGMD)
FBXL17
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL17 Gene

Disorders for FBXL17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBXL17 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
basal cell nevus syndrome
  • nevoid basal cell carcinoma syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FBXL17

Genetic Association Database (GAD)
FBXL17
Human Genome Epidemiology (HuGE) Navigator
FBXL17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL17
genes like me logo Genes that share disorders with FBXL17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBXL17 Gene

Publications for FBXL17 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. (PMID: 27234298) Raducu M … D'Angiolella V (The EMBO journal 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for FBXL17 Gene

Sources for FBXL17 Gene

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