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Aliases for FBXL16 Gene

Aliases for FBXL16 Gene

  • F-Box And Leucine-Rich Repeat Protein 16 2 3 4
  • C16orf22 3 4
  • Fbl16 3 4
  • Chromosome 16 Open Reading Frame 22 2
  • C380A1.1 (Novel Protein) 3
  • C380A1.1 3

External Ids for FBXL16 Gene

Previous HGNC Symbols for FBXL16 Gene

  • C16orf22

Previous GeneCards Identifiers for FBXL16 Gene

  • GC16M000683
  • GC16M000684
  • GC16M000685
  • GC16M000742
  • GC16M000664
  • GC16M000717

Summaries for FBXL16 Gene

Entrez Gene Summary for FBXL16 Gene

  • Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL16 Gene

FBXL16 (F-Box And Leucine-Rich Repeat Protein 16) is a Protein Coding gene. An important paralog of this gene is LRRC29.

UniProtKB/Swiss-Prot for FBXL16 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL16 Gene

Genomics for FBXL16 Gene

Regulatory Elements for FBXL16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL16 Gene

692,498 bp from pter
705,829 bp from pter
13,332 bases
Minus strand

Genomic View for FBXL16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL16 Gene

Proteins for FBXL16 Gene

  • Protein details for FBXL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 16
    Protein Accession:
    Secondary Accessions:
    • B3KR59
    • D3DU60
    • Q2MHR2
    • Q96S14
    • Q9UJI0

    Protein attributes for FBXL16 Gene

    479 amino acids
    Molecular mass:
    51658 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.
    • Sequence=AAK61245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL16 Gene


neXtProt entry for FBXL16 Gene

Proteomics data for FBXL16 Gene at MOPED

Post-translational modifications for FBXL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL16 Gene

Domains & Families for FBXL16 Gene

Gene Families for FBXL16 Gene

Protein Domains for FBXL16 Gene


Suggested Antigen Peptide Sequences for FBXL16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 7 LRR (leucine-rich) repeats.
  • Contains 1 F-box domain.
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL16: view

Function for FBXL16 Gene

Molecular function for FBXL16 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0061630 contributes_to ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with FBXL16: view

Phenotypes for FBXL16 Gene

genes like me logo Genes that share phenotypes with FBXL16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL16 Gene

Localization for FBXL16 Gene

Gene Ontology (GO) - Cellular Components for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with FBXL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FBXL16 Gene

Pathways & Interactions for FBXL16 Gene

SuperPathways for FBXL16 Gene

No Data Available

Interacting Proteins for FBXL16 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000318674 Q8N461-FXL16_HUMAN for FBXL16 Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with FBXL16: view

No data available for Pathways by source and SIGNOR curated interactions for FBXL16 Gene

Drugs & Compounds for FBXL16 Gene

No Compound Related Data Available

Transcripts for FBXL16 Gene

Unigene Clusters for FBXL16 Gene

F-box and leucine-rich repeat protein 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL16 Gene

No ASD Table

Relevant External Links for FBXL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL16 Gene

mRNA expression in normal human tissues for FBXL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL16 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.7), Brain - Caudate (basal ganglia) (x7.1), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x5.4), Brain - Amygdala (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for FBXL16 Gene

This gene is overexpressed in Serum (32.5), Frontal cortex (20.0), and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL16 Gene

SOURCE GeneReport for Unigene cluster for FBXL16 Gene Hs.513244

genes like me logo Genes that share expression patterns with FBXL16: view

Protein tissue co-expression partners for FBXL16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FBXL16 Gene

Orthologs for FBXL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FBXL16 35
  • 91.49 (n)
  • 95.61 (a)
FBXL16 36
  • 95 (a)
(Canis familiaris)
Mammalia FBXL16 35
  • 92.35 (n)
  • 97.49 (a)
FBXL16 36
  • 97 (a)
(Mus musculus)
Mammalia Fbxl16 35
  • 87.96 (n)
  • 96.45 (a)
Fbxl16 16
Fbxl16 36
  • 96 (a)
(Pan troglodytes)
Mammalia FBXL16 35
  • 99.83 (n)
  • 99.5 (a)
FBXL16 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fbxl16 35
  • 87.96 (n)
  • 96.66 (a)
(Monodelphis domestica)
Mammalia FBXL16 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL16 36
  • 77 (a)
(Gallus gallus)
Aves FBXL16 35
  • 81.41 (n)
  • 87.42 (a)
FBXL16 36
  • 85 (a)
(Anolis carolinensis)
Reptilia FBXL16 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl16 35
  • 73.64 (n)
  • 81.82 (a)
(Danio rerio)
Actinopterygii fbxl16 35
  • 74.39 (n)
  • 80 (a)
fbxl16 36
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012123 35
  • 63.27 (n)
  • 60.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32085 35
  • 64.82 (n)
  • 58.94 (a)
CG32085 36
  • 39 (a)
Species with no ortholog for FBXL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL16 Gene

Gene Tree for FBXL16 (if available)
Gene Tree for FBXL16 (if available)

Paralogs for FBXL16 Gene

Paralogs for FBXL16 Gene

(1) SIMAP similar genes for FBXL16 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL16: view

Variants for FBXL16 Gene

Sequence variations from dbSNP and Humsavar for FBXL16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2187902 -- 701,208(+) GAGGG(G/T)ACAGG intron-variant
rs3833954 -- 693,982(+) TGTGG(-/G)CGTGG utr-variant-3-prime
rs4465611 -- 701,988(-) GGCCT(C/T)TGTGT intron-variant
rs4984683 -- 696,884(+) ACGCC(A/C)ACCAG synonymous-codon, reference
rs4984684 -- 704,083(+) GCCAA(C/T)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL16 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
dgv2494n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
nsv827482 CNV Loss 20364138
dgv454n67 CNV Gain 20364138
nsv904808 CNV Loss 21882294
dgv2495n71 CNV Loss 21882294
nsv827486 CNV Gain 20364138
nsv904810 CNV Loss 21882294
nsv904812 CNV Loss 21882294
esv33054 CNV Gain+Loss 17666407

Variation tolerance for FBXL16 Gene

Residual Variation Intolerance Score: 15.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL16 Gene

Disorders for FBXL16 Gene

Relevant External Links for FBXL16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FBXL16: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL16 Gene

Publications for FBXL16 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 2 67
  2. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 67
  3. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 67
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67
  5. FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells. (PMID: 20043084) Sato K. … Yoshida K. (Int. J. Oncol. 2010) 67

Products for FBXL16 Gene

Sources for FBXL16 Gene

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