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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FBXL16 Gene

protein-coding GIFtS: 46
GCID: GC16M000742

F-box and leucine-rich repeat protein 16

(Previous name: chromosome 16 open reading frame 22 )
(Previous symbol: C16orf22)

Explore 1 disease affiliated with
FBXL16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
F-Box And Leucine-Rich Repeat Protein 16¹ ² ³		C380A1.1¹
C16orf22¹ ² ³		C380A1.1 (Novel Protein)²
Fbl16¹ ²		F-Box/LRR-Repeat Protein 16²
MGC33974¹		FBL16³
Chromosome 16 Open Reading Frame 22¹

External Ids:	HGNC: 14150¹	Entrez Gene: 146330²	Ensembl: ENSG00000127585⁷	OMIM: 609082⁵	UniProtKB: Q8N461³

Export aliases for FBXL16 gene to outside databases

Previous GC identifers: GC16M000683 GC16M000684 GC16M000685 GC16M000664

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBXL16:

Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif.

SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as

protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination

targets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: FXL16_HUMAN, Q8N461

Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FBXL16 gene promoter:
Max1 NF-1 FOXF2 AML1a AP-1 E47 c-Myb Zic3 c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for FBXL16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

FBXL16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL16 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M000742: view genomic region (about GC identifiers)

Start:	742,500 bp from pter	End:	755,829 bp from pter
Size:	13,330 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FXL16_HUMAN, Q8N461 (See protein sequence)

Recommended Name: F-box/LRR-repeat protein 16

Size: 479 amino acids; 51658 Da

Subunit: Interacts with SKP1 and CUL1 (By similarity)

Sequence caution: Sequence=AAK61245.1; Type=Erroneous gene model prediction;

Secondary accessions: D3DU60 Q2MHR2 Q96S14 Q9UJI0

Explore the universe of human proteins at neXtProt for FBXL16: NX_Q8N461

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N461

FBXL16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_699181.2

ENSEMBL proteins:

ENSP00000380746 ENSP00000455217 ENSP00000318674

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FBXL16 for domains About GeneDecksing

1 InterPro domain/family:

IPR001810 F-box_dom_cyclin-like

Graphical View of Domain Structure for InterPro Entry Q8N461

ProtoNet protein and cluster: Q8N461

UniProtKB/Swiss-Prot: FXL16_HUMAN, Q8N461

Similarity: Contains 1 F-box domain

Similarity: Contains 7 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: FXL16_HUMAN, Q8N461

Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By

similarity)

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1 GenomeRNAi human phenotype for FBXL16:

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FBXL16

1 Interacting protein for FBXL16 (Q8N461^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659²^,³	MINT-8261120 I2D: score=2

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for FBXL16 gene:

NM_153350.3

Unigene Cluster for FBXL16:

F-box and leucine-rich repeat protein 16

Hs.513244 [show with all ESTs]

Unigene Representative Sequence: NM_153350

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000562648(uc002cja.3) ENST00000397621(uc002cjb.3 uc021taa.1)

ENST00000562563 ENST00000562585 ENST00000324361

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Additional cDNA sequence:

AK091054.1 BC034014.1 BC036680.2

9 DOTS entries:

DT.95296794 DT.40223702 DT.411026 DT.95218804 DT.95192723 DT.95151988 DT.92053014 DT.86850847

DT.100750181

24/590 AceView cDNA sequences (see all 590):

BM127809 BU902994 CD251875 BM979638 BU552520 AI003325 BM127430 BX361982

BX106680 BM127440 CK823615 BU948838 CR613585 BM015643 AI391671 AA284939

AW572300 BX333485 CF129446 BQ423741 AA364723 AW081519 AI537602 BQ671851

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FBXL16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCGCCGCC

About this image

FBXL16 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FBXL16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL16

SOURCE GeneReport for Unigene cluster: Hs.513244

SABiosciences Custom PCR Arrays for FBXL16

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXL16 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FBXL16¹	F-box and leucine-rich repeat protein 16	81.55(n) 87.84(a)		416405 XM_414720.3 XP_414720.3
lizard (Anolis carolinensis)	Reptilia	FBXL16⁶	--	82(a)	1 ↔ 1	GL345026.1(3042-12082)
zebrafish (Danio rerio)	Actinopterygii	LOC797939¹	Fbxl16 protein-like	75.02(n) 80.63(a)		797939 NM_001201336.1 NP_001188265.1
fruit fly (Drosophila melanogaster)	Insecta	CG32085¹	CG32085	62.3(n) 55.76(a)		39311 NM_168470.1 NP_729732.1
thale cress (Arabidopsis thaliana)	eudicotyledons	EBF2⁶ AT5G23340⁶ (see all 4)	EIN3-binding F-box protein 2 leucine-rich repeats (LRRs), ribonuclease inhibito... (see all 4)	9(a) 17(a) (see all 4)	1 ↔ many 1 ↔ many (see all 4)	5(8794252-8797020) 5(7856189-7858319)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	F-box/LRR-repeat protein 3, putative, expressed (see all 5)	21(a) 13(a) (see all 5)	1 ↔ many 1 ↔ many (see all 5)	2(25508639-25509778) 11(24928010-24933143)

ENSEMBL Gene Tree for FBXL16 (if available)
TreeFam Gene Tree for FBXL16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FBXL16 gene

FBXL17² FBXL2² FBXL20² ENSG00000237102² FBXL13² FBXL7² AMN1² LRRC29²

FBXL15² FBXL4² FBXL14²

1 SIMAP similar gene for FBXL16 using alignment to 3 protein entries: FXL16_HUMAN (see all proteins):

FBXL2

FBXL16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74002850^1,2	C,	--	679627(+)	`CAGGCT/CGGACA`	1	--	nc-transcript-variant		3		WA EA	240
rs74002851^1,2	C,	--	679651(+)	`TAGGGT/CGGGCT`	1	--	nc-transcript-variant		2		WA	120
rs56056221^1,2		--	679865(+)	`TACCCC/TCCACC`	1	--	nc-transcript-variant		0	--	--	--	--
rs60658291^1,2	C	--	679895(+)	`CACCTG/ACCCTC`	1	--	nc-transcript-variant		1		WA	2
rs13336378^1,2	C,F,A	--	679963(+)	`CACCTG/ACCCTC`	1	--	nc-transcript-variant		3		NA	6
rs45581333^1,2	C,	--	742459(+)	`GCCCAC/TCTACA`	1	--	ds500¹		0	--	--	--	--
rs192324545^1,2		--	742517(+)	`TTTTTA/TAATAT`	1	--	ut3¹		0	--	--	--	--
rs185682837^1,2		--	742532(+)	`TTTTAA/TAAACA`	1	--	ut3¹		0	--	--	--	--
rs149561458^1,2		--	742633(+)	`AAGAAA/CATGAT`	1	--	ut3¹		0	--	--	--	--
rs76076782^1,2		--	742685(+)	`TTTTCC/TTCCTA`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for FBXL16 (742500 - 755829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for FBXL16
10 CNVs: 49738 49727 29986 49728 3987 29982 5329 30732 29983 29985
1 Indel: 11115

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FBXL16 for disorders           About GeneDecksing

OMIM gene information: 609082    OMIM disorders: --

1 disease for FBXL16:    About MalaCards

spinal cord injury

Export disorders for FBXL16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FBXL16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FBXL16)

Utopia: connect your pdf to the dynamic
world of online information

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{1, 2, 3} Daniels R.J....Higgs D.R. (2001)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
FBXL16 is a novel E2F1-regulated gene commonly upregu lated in p16INK4A- and p14ARF-silenced HeLa cells. (PubMed id 20043084)¹ Sato K....Yoshida K. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)¹ Jin J....Harper J.W. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 146330	HGNC: 14150	AceView: DKFZp434F054andFBXL16andLOC339123	Ensembl:ENSG00000127585	euGenes: HUgn146330
ECgene: FBXL16	H-InvDB: FBXL16

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FBXL16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FBXL16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FBXL16 gene:
Search GeneIP for patents involving FBXL16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes FBXL16 gene at Home site.

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FBXL16 Gene

F-box and leucine-rich repeat protein 16

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FBXL16 Gene

F-box and leucine-rich repeat protein 16

Aliasesfor FBXL16 gene

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Protein Domains /Familiesfor FBXL16 gene

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for FBXL16 gene

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