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Aliases for FBXL16 Gene

Aliases for FBXL16 Gene

  • F-Box And Leucine Rich Repeat Protein 16 2 3 5
  • C16orf22 3 4
  • Fbl16 3 4
  • F-Box And Leucine-Rich Repeat Protein 16 4
  • Chromosome 16 Open Reading Frame 22 2
  • F-Box/LRR-Repeat Protein 16 3
  • C380A1.1 (Novel Protein) 3
  • C380A1.1 3

External Ids for FBXL16 Gene

Previous HGNC Symbols for FBXL16 Gene

  • C16orf22

Previous GeneCards Identifiers for FBXL16 Gene

  • GC16M000683
  • GC16M000684
  • GC16M000685
  • GC16M000742
  • GC16M000664
  • GC16M000717
  • GC16M000746
  • GC16M000815
  • GC16M000839

Summaries for FBXL16 Gene

Entrez Gene Summary for FBXL16 Gene

  • Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL16 Gene

FBXL16 (F-Box And Leucine Rich Repeat Protein 16) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL20.

UniProtKB/Swiss-Prot for FBXL16 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL16 Gene

Genomics for FBXL16 Gene

Regulatory Elements for FBXL16 Gene

Enhancers for FBXL16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000709 1.2 Ensembl ENCODE 20.9 -4.8 -4778 3.2 ZFP64 SIN3A ARID4B ZNF2 GLIS2 ZNF143 FOS ZNF263 MIER2 REST JMJD8 FBXL16 TMEM204 CHTF18 RPUSD1 MPG WFIKKN1 TPSG1 ENSG00000260954 ENSG00000262528
GH16F001530 1.4 FANTOM5 Ensembl ENCODE 4.7 -829.4 -829395 10.0 CTCF LEF1 MAX ZIC2 ZNF2 RAD21 GATA3 ZFHX2 POLR2A TCF7L2 TMEM204 TELO2 FAHD1 PTX4 IFT140 CCDC154 NME3 TSR3 FBXL16 CLCN7
GH16F000620 1.2 Ensembl ENCODE 5 +83.8 83800 2.8 HDGF HDAC1 ATF1 PKNOX1 CREB3L1 NFRKB SIN3A RAD21 RFX5 GLIS2 WFIKKN1 RAB40C METTL26 FBXL16 GC16M000614
GH16F001026 0.5 FANTOM5 11.1 -320.8 -320762 0.2 RFX1 REST FBXL16 ENSG00000260807 RHBDL1 SOX8 RAB40C BAIAP3 PIR47161 LOC102723753
GH16F001158 1.2 FANTOM5 ENCODE 4.5 -454.0 -454043 1.8 PKNOX1 ZFP64 ARID4B RARA GLIS2 EGR2 THAP11 SP5 USF2 MXD4 IFT140 LOC105371038 HN1L ENSG00000260447 NME3 CCDC154 ENSG00000262528 SNHG19 ENSG00000268836 EME2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL16 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001798866 -71 601 E2F1 MAZ SUZ12 POLR2A SCRT2 SIN3A ZBTB7A ZBTB26

Genomic Location for FBXL16 Gene

692,498 bp from pter
705,829 bp from pter
13,332 bases
Minus strand

Genomic View for FBXL16 Gene

Genes around FBXL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL16 Gene

Proteins for FBXL16 Gene

  • Protein details for FBXL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 16
    Protein Accession:
    Secondary Accessions:
    • B3KR59
    • D3DU60
    • Q2MHR2
    • Q96S14
    • Q9UJI0

    Protein attributes for FBXL16 Gene

    479 amino acids
    Molecular mass:
    51658 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.
    • Sequence=AAK61245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL16 Gene


neXtProt entry for FBXL16 Gene

Post-translational modifications for FBXL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL16 Gene

Domains & Families for FBXL16 Gene

Gene Families for FBXL16 Gene

Protein Domains for FBXL16 Gene

Suggested Antigen Peptide Sequences for FBXL16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 7 LRR (leucine-rich) repeats.
  • Contains 1 F-box domain.
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL16: view

Function for FBXL16 Gene

Molecular function for FBXL16 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXL16: view

Animal Models for FBXL16 Gene

MGI Knock Outs for FBXL16:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL16 Gene

Localization for FBXL16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL16 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FBXL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FBXL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL16 Gene

Pathways & Interactions for FBXL16 Gene

genes like me logo Genes that share pathways with FBXL16: view

Gene Ontology (GO) - Biological Process for FBXL16 Gene


No data available for SIGNOR curated interactions for FBXL16 Gene

Transcripts for FBXL16 Gene

Unigene Clusters for FBXL16 Gene

F-box and leucine-rich repeat protein 16:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL16 Gene

No ASD Table

Relevant External Links for FBXL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXL16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL16 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.7), Brain - Caudate (basal ganglia) (x7.1), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x5.4), Brain - Amygdala (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for FBXL16 Gene

This gene is overexpressed in Serum (32.5), Frontal cortex (20.0), and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FBXL16 Gene

Protein tissue co-expression partners for FBXL16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL16 Gene:


SOURCE GeneReport for Unigene cluster for FBXL16 Gene:

genes like me logo Genes that share expression patterns with FBXL16: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXL16 Gene

Orthologs for FBXL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL16 34 35
  • 99.83 (n)
(Canis familiaris)
Mammalia FBXL16 34 35
  • 92.35 (n)
(Bos Taurus)
Mammalia FBXL16 34 35
  • 91.49 (n)
(Mus musculus)
Mammalia Fbxl16 34 16 35
  • 87.96 (n)
(Rattus norvegicus)
Mammalia Fbxl16 34
  • 87.96 (n)
(Monodelphis domestica)
Mammalia FBXL16 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FBXL16 35
  • 77 (a)
(Gallus gallus)
Aves FBXL16 34 35
  • 81.41 (n)
(Anolis carolinensis)
Reptilia FBXL16 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl16 34
  • 73.64 (n)
(Danio rerio)
Actinopterygii fbxl16 34 35
  • 74.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32085 34 35
  • 64.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012123 34
  • 63.27 (n)
Species where no ortholog for FBXL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL16 Gene

Gene Tree for FBXL16 (if available)
Gene Tree for FBXL16 (if available)

Paralogs for FBXL16 Gene

Paralogs for FBXL16 Gene

(1) SIMAP similar genes for FBXL16 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBXL16: view

Variants for FBXL16 Gene

Sequence variations from dbSNP and Humsavar for FBXL16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10664962 -- 696,249(+) TTATT(-/TATTCATT)CATTC intron-variant
rs111252823 -- 695,340(+) CCCCG(C/T)GCAGC intron-variant
rs111287434 -- 701,615(+) ACCCA(C/G)CCAGC intron-variant
rs111680668 -- 692,049(+) TTCGG(-/CCTC)CCTAA downstream-variant-500B, upstream-variant-2KB
rs111704567 -- 699,282(+) ACCCT(C/T)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL16 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv9321 CNV gain+loss 18304495
nsv827486 CNV gain 20364138
nsv827482 CNV loss 20364138
nsv571021 CNV loss 21841781
nsv571012 CNV loss 21841781
nsv526903 CNV loss 19592680
nsv516590 CNV loss 19592680
nsv471065 CNV gain 18288195
nsv471063 CNV loss 18288195
nsv457311 CNV loss 19166990
nsv1160326 CNV duplication 26073780
nsv1160325 CNV duplication 26073780
nsv1147718 CNV insertion 26484159
nsv1131101 CNV deletion 24896259
esv33054 CNV gain+loss 17666407
esv2422427 CNV duplication 17116639
dgv4825n54 CNV loss 21841781
dgv454n67 CNV gain 20364138

Variation tolerance for FBXL16 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL16 Gene

Disorders for FBXL16 Gene

Relevant External Links for FBXL16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL16 Gene

Publications for FBXL16 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FBXL16 Gene

Sources for FBXL16 Gene

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