Aliases for FBXL16 Gene
Aliases for FBXL16 Gene
External Ids for FBXL16 Gene
- HGNC: 14150
- Entrez Gene: 146330
- Ensembl: ENSG00000127585
- OMIM: 609082
- UniProtKB: Q8N461
Previous HGNC Symbols for FBXL16 Gene
- C16orf22
Previous GeneCards Identifiers for FBXL16 Gene
- GC16M000683
- GC16M000684
- GC16M000685
- GC16M000742
- GC16M000664
- GC16M000717
- GC16M000746
- GC16M000815
- GC16M000839
- GC16M000863
Summaries for FBXL16 Gene
-
Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXL16 Gene
FBXL16 (F-Box And Leucine Rich Repeat Protein 16) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL20.
UniProtKB/Swiss-Prot for FBXL16 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL16 Gene
Genomics for FBXL16 Gene
Regulatory Elements for FBXL16 Gene
Enhancers for FBXL16 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL16 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for FBXL16 Gene
- Chromosome:
- 16
- Start:
- 692,498 bp from pter
- End:
- 705,829 bp from pter
- Size:
- 13,332 bases
- Orientation:
- Minus strand
Genomic View for FBXL16 Gene
Genes around FBXL16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
FBXL16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL16 Gene
Proteins for FBXL16 Gene
-
Protein details for FBXL16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N461-FXL16_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 16
- Protein Accession:
- Q8N461
- B3KR59
- D3DU60
- Q2MHR2
- Q96S14
- Q9UJI0
Protein attributes for FBXL16 Gene
- Size:
- 479 amino acids
- Molecular mass:
- 51658 Da
- Quaternary structure:
-
- Interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=AAK61245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for FBXL16 Gene
Post-translational modifications for FBXL16 Gene
Other Protein References for FBXL16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXL16
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- Invitrogen Antibodies for FBXL16
- antibodies-online Antibodies for FBXL16: See all 38
- GeneTex FBXL16 antibody for FBXL16
-
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Protein Products
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- Novus Biologicals proteins for FBXL16
- antibodies-online Proteins for FBXL16: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL16
Assay Products
- antibodies-online Kits for FBXL16: See all 21
No data available for DME Specific Peptides for FBXL16 Gene
Domains & Families for FBXL16 Gene
Gene Families for FBXL16 Gene
Protein Domains for FBXL16 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL16 Gene
Function for FBXL16 Gene
Molecular function for FBXL16 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXL16 Gene
- MGI mutant phenotypes for FBXL16:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXL16:
Animal Models for FBXL16 Gene
- MGI Knock Outs for FBXL16:
-
- Fbxl16 tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL16 gene
-
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- Search ViGene Biosciences for FBXL16
CRISPR Products
-
OriGene CRISPR knockouts for FBXL16
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL16
- GenScript: Design CRISPR guide RNA sequences for FBXL16
miRNA for FBXL16 Gene
- miRTarBase miRNAs that target FBXL16
-
- hsa-mir-296-3p (MIRT038481)
- hsa-mir-149-5p (MIRT045637)
- hsa-mir-1185-1-3p (MIRT440666)
- hsa-mir-544a (MIRT440667)
- hsa-mir-1185-2-3p (MIRT440668)
- hsa-mir-6809-3p (MIRT623952)
- hsa-mir-6833-3p (MIRT623953)
- hsa-mir-4768-5p (MIRT623954)
- hsa-mir-4753-3p (MIRT623955)
- hsa-mir-6873-3p (MIRT623956)
- hsa-mir-6794-3p (MIRT623957)
- hsa-mir-130b-5p (MIRT623958)
- hsa-mir-6817-3p (MIRT623959)
- hsa-mir-7110-3p (MIRT623960)
- hsa-mir-1304-3p (MIRT623961)
- hsa-mir-4639-3p (MIRT623962)
- hsa-mir-4709-5p (MIRT623963)
- hsa-mir-421 (MIRT623964)
- hsa-mir-8057 (MIRT658217)
- hsa-mir-3191-5p (MIRT658218)
- hsa-mir-505-3p (MIRT658219)
- hsa-mir-7159-5p (MIRT658220)
- hsa-mir-760 (MIRT658221)
- hsa-mir-6822-3p (MIRT658222)
- hsa-mir-6504-5p (MIRT658223)
- hsa-mir-3064-5p (MIRT658224)
- hsa-mir-664a-5p (MIRT658225)
- hsa-mir-4794 (MIRT658226)
- hsa-mir-6824-3p (MIRT658227)
- hsa-mir-6764-3p (MIRT658228)
- hsa-mir-330-5p (MIRT658229)
- hsa-mir-326 (MIRT658230)
- hsa-mir-518c-5p (MIRT658231)
- hsa-mir-4272 (MIRT658232)
miRNA Products
- Search ViGene Biosciences for FBXL16
Inhibitory RNA Products
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-
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Cell Line Products
-
Horizon Cell Lines for FBXL16
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL16 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBXL16 Gene
Localization for FBXL16 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL16 Gene
Pathways & Interactions for FBXL16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL16 Gene
4 Reactome pathways for FBXL16 Gene
Interacting Proteins for FBXL16 Gene
Selected Interacting proteins:
Q8N461-FXL16_HUMAN
ENSP00000318674
for FBXL16 Gene via
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL16 Gene
Transcripts for FBXL16 Gene
mRNA/cDNA for FBXL16 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (590) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL16 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL16
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL16
- GenScript: Design CRISPR guide RNA sequences for FBXL16
miRNA Products
- Search ViGene Biosciences for FBXL16
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL16
- Browse OriGene Inhibitory RNA Products For FBXL16
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL16 gene
Clone Products
-
OriGene ORF clones in human for FBXL16
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Flow Cytometry Products
Expression for FBXL16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for FBXL16 Gene
This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.7), Brain - Caudate (basal ganglia) (x7.1), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x5.4), Brain - Amygdala (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Hippocampus (x4.3).
This gene is overexpressed in Serum (32.5), Frontal cortex (20.0), and Fetal Brain (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL16 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FBXL16 Gene:
FBXL16SOURCE GeneReport for Unigene cluster for FBXL16 Gene:
Hs.513244Evidence on tissue expression from TISSUES for FBXL16 Gene
- Nervous system(4.8)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for FBXL16
-
OriGene qPCR primer pairs and template standards for FBXL16
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL16 Gene
Orthologs for FBXL16 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL16 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL16 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL16 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl16 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXL16 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL16 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXL16 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL16 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl16 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxl16 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32085 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012123 34 |
|
- Species where no ortholog for FBXL16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL16 Gene
Variants for FBXL16 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003040 | -- | 693,954(+) | GGCGA(A/G)CGAGT | utr-variant-3-prime | |
| rs1000175819 | -- | 702,879(+) | TGCCC(A/G)TCCTC | intron-variant | |
| rs1000480062 | -- | 697,918(+) | TGACG(A/G/T)GAACC | intron-variant | |
| rs1000607163 | -- | 692,806(+) | GACCA(A/C)TCAGC | utr-variant-3-prime | |
| rs1000610108 | -- | 702,682(+) | GGATC(A/G)TGCCA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv454n67 | CNV | gain | 20364138 |
| dgv4825n54 | CNV | loss | 21841781 |
| esv2422427 | CNV | duplication | 17116639 |
| esv33054 | CNV | gain+loss | 17666407 |
| nsv1131101 | CNV | deletion | 24896259 |
| nsv1147718 | CNV | insertion | 26484159 |
| nsv1160325 | CNV | duplication | 26073780 |
| nsv1160326 | CNV | duplication | 26073780 |
| nsv457311 | CNV | loss | 19166990 |
| nsv471063 | CNV | loss | 18288195 |
| nsv471065 | CNV | gain | 18288195 |
| nsv516590 | CNV | loss | 19592680 |
| nsv526903 | CNV | loss | 19592680 |
| nsv571012 | CNV | loss | 21841781 |
| nsv571021 | CNV | loss | 21841781 |
| nsv827482 | CNV | loss | 20364138 |
| nsv827486 | CNV | gain | 20364138 |
| nsv9321 | CNV | gain+loss | 18304495 |
| nsv952898 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.28;
6.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXL16 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL16
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL16 Gene
Disorders for FBXL16 Gene
Relevant External Links for FBXL16
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXL16
No disorders were found for FBXL16 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL16 Gene
Publications for FBXL16 Gene
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for FBXL16 Gene
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- antibodies-online Antibodies for FBXL16: See all 38
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer