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FBXL15 Gene

protein-coding   GIFtS: 46
GCID: GC10P104178

F-Box And Leucine-Rich Repeat Protein 15

(Previous name: F-box only protein 37)
(Previous symbol: FBXO37)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
F-Box And Leucine-Rich Repeat Protein 151 2     Fbl152
FBXO371 2 3     PSD2
F-Box Only Protein 371 2 3     F-Box/LRR-Repeat Protein 152
JET2 5     Pleckstrin And Sec7 Domain Protein2

External Ids:    HGNC: 281551   Entrez Gene: 791762   Ensembl: ENSG000001078727   OMIM: 6102875   UniProtKB: Q9H4693   

Export aliases for FBXL15 gene to outside databases

Previous GC identifers: GC10P103843 GC10P104169 GC10P097813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for FBXL15 Gene:
FBXL15 (F-box and leucine-rich repeat protein 15) is a protein-coding gene. Diseases associated with FBXL15 include yellow fever, and smallpox. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive
regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance.
Also mediates ubiquitination of SMURF2 and WWP2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FBXL15 gene promoter:
         p53   NRSF form 1   Nkx2-5   NRSF form 2   PPAR-alpha   Ik-2   HOXA5   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXL15 promoter sequence
   Search Chromatin IP Primers for FBXL15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FBXL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

FBXL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL15 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104178:  view genomic region     (about GC identifiers)

Start:
104,178,946 bp from pter      End:
104,182,893 bp from pter
Size:
3,948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 15  
Size: 300 amino acids; 32998 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1,
RBX1 and FBXL15
Sequence caution: Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12517.1;
Type=Erroneous gene model prediction; Sequence=CAI12518.1; Type=Erroneous gene model prediction;
Sequence=CAI12519.1; Type=Erroneous gene model prediction; Sequence=CAI12520.1; Type=Erroneous gene model
prediction; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1L4J8 B1AKX8 B1AKX9 B1AKY0 B1AKY1 C9JWA4 Q0D2Q3 Q49AL7 Q5JWA5

Explore the universe of human proteins at neXtProt for FBXL15: NX_Q9H469

Explore proteomics data for FBXL15 at MOPED


See FBXL15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_077302.3  
ENSEMBL proteins: 
 ENSP00000411435   ENSP00000392215   ENSP00000358972   ENSP00000405961   ENSP00000403646  
 ENSP00000224862  

FBXL15 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for FBXL15

FBXL15 Assay Products:

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Cloud-Clone Corp. ELISAs for FBXL15
Cloud-Clone Corp. CLIAs for FBXL15


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
FBXL: F-boxes / Leucine-rich repeats

1 InterPro protein domain:
 IPR001810 F-box_dom

Graphical View of Domain Structure for InterPro Entry Q9H469

ProtoNet protein and cluster: Q9H469

UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469
Similarity: Belongs to the FBXL15 family
Similarity: Contains 1 F-box domain
Similarity: Contains 5 LRR (leucine-rich) repeats


FBXL15 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: FXL15_HUMAN, Q9H469
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive
regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance.
Also mediates ubiquitination of SMURF2 and WWP2

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842contributes to ubiquitin-protein ligase activity IDA--
GO:0005515protein binding IPI--
     
FBXL15 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for FBXL15:
 Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Wnt reporter downregulated 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FBXL15
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FBXL15

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXL15
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXL15

miRNA
Products:
    
miRTarBase miRNAs that target FBXL15:
hsa-mir-100-5p (MIRT048418)

Block miRNA regulation of human, mouse, rat FBXL15 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate FBXL15:
hsa-miR-127-5p hsa-miR-455-3p hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidFBXL15 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for FBXL15
Predesigned siRNA for gene silencing in human, mouse, rat FBXL15

Gene Editing
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DNA2.0 Custom Protein Engineering Service for FBXL15

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OriGene clones in human, mouse for FBXL15 (see all 6)
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GenScript: all cDNA clones in your preferred vector: FBXL15 (NM_024326)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
FXL15_HUMAN, Q9H469: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular2
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA--
GO:0019005SCF ubiquitin ligase complex IDA--

FBXL15 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Array including FBXL15: 

          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for FBXL15

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for FBXL15 (Q9H4691, 2 ENSP000002248624) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
InteractantInteraction Details
GeneCardExternal ID(s)
SMURF1Q9HCE71, 2, ENSP000003546214EBI-6144096,EBI-976466 MINT-8199952 MINT-8298454 MINT-8199931 MINT-8298316 MINT-8298472 MINT-8198843 STRING: ENSP00000354621
SMURF2Q9HAU41, 2, ENSP000002624354EBI-6144096,EBI-396727 MINT-8200043 MINT-8298439 MINT-8297030 STRING: ENSP00000262435
SKP1P632082, ENSP000002314874MINT-8198846 STRING: ENSP00000231487
HECW1Q76N892, ENSP000003792284MINT-8298370 STRING: ENSP00000379228
HECW2Q9P2P52, ENSP000002609834MINT-8298383 STRING: ENSP00000260983
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000086G2/M transition of mitotic cell cycle IMP--
GO:0009953dorsal/ventral pattern formation ISS--
GO:0016567protein ubiquitination IDA--
GO:0030282bone mineralization ISS--
GO:0030513positive regulation of BMP signaling pathway IMP--

FBXL15 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for FBXL15 (FXL15)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for FBXL15 gene: 
NM_024326.3  

Unigene Cluster for FBXL15:

F-box and leucine-rich repeat protein 15
Hs.380081  [show with all ESTs]
Unigene Representative Sequence: NM_024326
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000432590 ENST00000481808 ENST00000457067 ENST00000369956(uc001kvj.1 uc001kvl.1)
ENST00000440407 ENST00000425536 ENST00000224862(uc001kvk.2)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat FBXL15 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate FBXL15:
hsa-miR-127-5p hsa-miR-455-3p hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidFBXL15 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for FBXL15
Predesigned siRNA for gene silencing in human, mouse, rat FBXL15
Clone
Products:
     
OriGene clones in human, mouse for FBXL15 (see all 6)
OriGene ORF clones in mouse, rat for FBXL15
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: FBXL15 (NM_024326)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL15
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15
Primer
Products:
    
OriGene qPCR primer pairs and template standards for FBXL15
OriGene qSTAR qPCR primer pairs in human, mouse for FBXL15
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXL15
  QuantiTect SYBR Green Assays in human, mouse, rat FBXL15
  QuantiFast Probe-based Assays in human, mouse, rat FBXL15

Additional mRNA sequence: 

AK122684.1 BC002912.2 BC036120.1 BC130566.1 

15 DOTS entries:

DT.444008  DT.121252620  DT.97804713  DT.97844337  DT.91744689  DT.95338664  DT.91744694  DT.121252609 
DT.75183986  DT.95124126  DT.101981950  DT.99949070  DT.121252574  DT.428527  DT.86848037 

Selected AceView cDNA sequences (see all 160):

BU677737 BG257343 BQ945255 BI858979 BQ001207 CA314694 BQ958249 CR592302 
BI088482 BU633597 BQ777226 BQ447584 AI638361 BM703242 BQ787928 BM458776 
BQ086241 BI963018 CR591228 BM068724 BG775574 H08374 CR616238 CR595934 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 (see all 7)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b
SP1:        -     -     -     -     -     -           -                                             
SP2:                                                  -                                             
SP3:                                                  -                                             
SP4:                                      -           -                                             
SP5:                          -     -     -           -                                             


ECgene alternative splicing isoforms for FBXL15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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FBXL15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGCGGAGTC
FBXL15 Expression
About this image

FBXL15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

FBXL15 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.380081
    Pathway & Disease-focused RT2 Profiler PCR Array including FBXL15: 
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for FBXL15
OriGene qSTAR qPCR primer pairs in human, mouse for FBXL15
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FBXL15
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QuantiFast Probe-based Assays in human, mouse, rat FBXL15
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for FBXL15 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fbxl151 , 5 F-box and leucine-rich repeat protein 151, 5 88.78(n)1
96.33(a)1
  19 (38.81 cM)5
684311  NM_133694.21  NP_598455.21 
 463281845 
chicken
(Gallus gallus)
Aves FBXL151 F-box and leucine-rich repeat protein 15 67.5(n)
65.48(a)
  428951  XM_426506.3  XP_426506.2 
lizard
(Anolis carolinensis)
Reptilia FBXL156
F-box and leucine-rich repeat protein 15
54(a)
1 ↔ 1
GL343196.1(260320-272639)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.203892 Transcribed sequence with weak similarity to protein more 70.13(n)    BX757424.1 
zebrafish
(Danio rerio)
Actinopterygii fbxl151 F-box and leucine-rich repeat protein 15 64.77(n)
61.92(a)
  405878  NM_212942.1  NP_998107.1 
fruit fly
(Drosophila melanogaster)
Insecta jet1 jetlag 45.32(n)
32.02(a)
  33705  NM_001042867.2  NP_001036332.1 


ENSEMBL Gene Tree for FBXL15 (if available)
TreeFam Gene Tree for FBXL15 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for FBXL15 gene
FBXL22  FBXL172  FBXL202  ENSG000002371022  FBXL132  FBXL162  FBXL72  LRRC292  
FBXL142  FBXL42  

FBXL15 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for FBXL15
PGOHUM00000258537


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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7 SNPs for FBXL15    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2016171411,2
--104181760(+) CACGCC/TTGCAG 2 L syn10--------
rs1136339241,2
C--104181799(+) TGGACA/GGGCTG 2 R G mis10--------
rs1412964721,2
--104182190(+) AAGGGC/TCTCTA 1 -- int10--------
rs1502044521,2
--104182242(+) TCAACC/TAATGT 1 -- int10--------
rs3708220161,2
----104181999(+) GAACTC/TCACCA 2 L syn10--------
rs1124596791,2
----104182475(+) AGTCCG/AAGGCT 1 -- int11Minor allele frequency- A:0.50NA 2
rs3761471681,2
----104182052(+) CAGGTG/TCCTGG 1 -- int10--------

HapMap Linkage Disequilibrium report for FBXL15 (104178946 - 104182893 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for FBXL15:    About this table    
Variant IDTypeSubtypePubMed ID
dgv814n71CNV Loss21882294
nsv895970CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing FBXL15
DNA2.0 Custom Variant and Variant Library Synthesis for FBXL15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610287    OMIM disorders: --

6 diseases for FBXL15:    
About MalaCards
yellow fever    smallpox    endocarditis    malaria
prostate cancer    prostatitis

1 disease from the University of Copenhagen DISEASES database for FBXL15:
Smallpox

FBXL15 for disorders           About GeneDecksing


Export disorders for FBXL15 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for FBXL15 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with FBXL15)
    Utopia: connect your pdf to the dynamic
world of online information

  1. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1, 2 Cui Y.... Zhang L. (EMBO J. 2011)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  9. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (J. Proteome Res. 2009)
  10. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PubMed id 17463251)1 Busino L.... Pagano M. (Science 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79176 HGNC: 28155 AceView: FBXL15 Ensembl:ENSG00000107872 euGenes: HUgn79176
ECgene: FBXL15 H-InvDB: FBXL15

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for FBXL15 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for FBXL15 gene:
Search GeneIP for patents involving FBXL15

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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