Aliases for FBXL15 Gene
Aliases for FBXL15 Gene
External Ids for FBXL15 Gene
- HGNC: 28155
- Entrez Gene: 79176
- Ensembl: ENSG00000107872
- OMIM: 610287
- UniProtKB: Q9H469
Previous HGNC Symbols for FBXL15 Gene
- FBXO37
Previous GeneCards Identifiers for FBXL15 Gene
- GC10P103843
- GC10P104169
- GC10P097813
- GC10P104178
Summaries for FBXL15 Gene
GeneCards Summary for FBXL15 Gene
FBXL15 (F-Box And Leucine Rich Repeat Protein 15) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL20.
UniProtKB/Swiss-Prot for FBXL15 Gene
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL15 Gene
Genomics for FBXL15 Gene
Regulatory Elements for FBXL15 Gene
Enhancers for FBXL15 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL15 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXL15 gene promoter:
Regulatory Element Products
Genomic Location for FBXL15 Gene
- Chromosome:
- 10
- Start:
- 102,419,061 bp from pter
- End:
- 102,423,138 bp from pter
- Size:
- 4,078 bases
- Orientation:
- Plus strand
Genomic View for FBXL15 Gene
Genes around FBXL15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.32 by Ensembl
- 10q24.32 by Entrez Gene
- 10q24.32 by HGNC
FBXL15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL15 Gene
Proteins for FBXL15 Gene
-
Protein details for FBXL15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H469-FXL15_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 15
- Protein Accession:
- Q9H469
- A1L4J8
- B1AKX8
- B1AKX9
- B1AKY0
- B1AKY1
- C9JWA4
- Q0D2Q3
- Q49AL7
- Q5JWA5
Protein attributes for FBXL15 Gene
- Size:
- 300 amino acids
- Molecular mass:
- 32998 Da
- Quaternary structure:
-
- Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
- SequenceCaution:
-
- Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12519.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for FBXL15 Gene
Post-translational modifications for FBXL15 Gene
Other Protein References for FBXL15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXL15
-
Abcam antibodies for FBXL15
- Invitrogen Antibodies for FBXL15
- antibodies-online Antibodies for FBXL15: See all 31
- Search GeneTex for Antibodies for FBXL15
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FBXL15
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- antibodies-online Proteins for FBXL15: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL15
Assay Products
- antibodies-online Kits for FBXL15: See all 21
No data available for DME Specific Peptides for FBXL15 Gene
Domains & Families for FBXL15 Gene
Gene Families for FBXL15 Gene
Protein Domains for FBXL15 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H469- Family:
-
- Belongs to the FBXL15 family.
Function for FBXL15 Gene
Molecular function for FBXL15 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 21572392 |
Phenotypes for FBXL15 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL15 gene
-
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- Search ViGene Biosciences for FBXL15
CRISPR Products
-
OriGene CRISPR knockouts for FBXL15
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL15
- GenScript: Design CRISPR guide RNA sequences for FBXL15
miRNA for FBXL15 Gene
- miRTarBase miRNAs that target FBXL15
miRNA Products
- Search ViGene Biosciences for FBXL15
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXL15
- Browse OriGene Inhibitory RNA Products For FBXL15
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL15 gene
Clone Products
-
OriGene ORF clones in human for FBXL15
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FBXL15
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL15 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL15 Gene
Localization for FBXL15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL15 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 2 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA,IEA | 21572392 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0019005 | SCF ubiquitin ligase complex | IDA | 21572392 |
Pathways & Interactions for FBXL15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL15 Gene
4 Reactome pathways for FBXL15 Gene
UniProtKB/Swiss-Prot Q9H469-FXL15_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXL15 Gene
Selected Interacting proteins:
Q9H469-FXL15_HUMAN
ENSP00000224862
for FBXL15 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IMP | 21572392 |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0009953 | dorsal/ventral pattern formation | ISS | -- |
| GO:0016567 | protein ubiquitination | IDA,IEA | 21572392 |
| GO:0030282 | bone mineralization | IEA,ISS | -- |
No data available for SIGNOR curated interactions for FBXL15 Gene
Transcripts for FBXL15 Gene
mRNA/cDNA for FBXL15 Gene
- (5) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (160) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL15
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL15
- GenScript: Design CRISPR guide RNA sequences for FBXL15
miRNA Products
- Search ViGene Biosciences for FBXL15
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for FBXL15
- Browse OriGene Inhibitory RNA Products For FBXL15
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL15 gene
Clone Products
-
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Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: | - | - |
Expression for FBXL15 Gene
This gene is overexpressed in Spinal cord (18.3), Frontal cortex (16.1), Retina (12.8), and Peripheral blood mononuclear cells (11.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL15 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL15 Gene:
FBXL15SOURCE GeneReport for Unigene cluster for FBXL15 Gene:
Hs.380081Evidence on tissue expression from TISSUES for FBXL15 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs and template standards for FBXL15
-
OriGene qPCR primer pairs for FBXL15
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL15 Gene
Orthologs for FBXL15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL15 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL15 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FBXL15 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl15 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl15 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXL15 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL15 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXL15 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL15 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl15 34 |
|
||
| Str.20389 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | fbxl15 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009335 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | jet 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXL15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL15 Gene
Variants for FBXL15 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000325831 | -- | 102,418,414(+) | ACACA(C/T)ACAGA | intron-variant, upstream-variant-2KB | |
| rs1000872443 | -- | 102,422,498(+) | ACACA(G/T)TGGGA | intron-variant | |
| rs1001330523 | -- | 102,423,001(+) | CGCCT(A/G)CCAAT | intron-variant, utr-variant-3-prime | |
| rs1002159288 | -- | 102,421,576(+) | GCCCC(A/G/T)CAGTA | intron-variant, upstream-variant-2KB | |
| rs1002206188 | -- | 102,421,920(+) | GAATC(C/T)GCAGC | upstream-variant-2KB, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1159761 | CNV | deletion | 26073780 |
| nsv951006 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.34;
26.50% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXL15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL15 Gene
Disorders for FBXL15 Gene
Relevant External Links for FBXL15
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXL15
No disorders were found for FBXL15 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL15 Gene
Publications for FBXL15 Gene
- SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PMID: 21572392) Cui Y. … Zhang L. (EMBO J. 2011) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
Products for FBXL15 Gene
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- Custom Antibody ServicesOriGene Antibodies for FBXL15
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- antibodies-online Antibodies for FBXL15: See all 31
- antibodies-online Kits for FBXL15: See all 21
- antibodies-online Proteins for FBXL15: See all 9
- Search antibodies-online for peptides
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- Search GeneTex for Proteins for FBXL15
- ViGene Biosciences adenoviral particle packaged cDNA for FBXL15 gene
- ViGene Biosciences lentiviral particle packaged cDNA for FBXL15 gene
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- VectorBuilder custom plasmid, inducible vectors for FBXL15
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer