FBXL15 Gene
protein-coding GIFtS: 45
GCID: GC10P104178
|
|
F-box and leucine-rich repeat protein 15(Previous name: F-box only protein 37 ) (Previous symbol: FBXO37)
| |
Aliases for FBXL15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 151 2 | | JET2 | | FBXO371 2 3 | | PSD2 | | F-Box Only Protein 371 2 3 | | F-Box/LRR-Repeat Protein 152 | | Fbl151 2 | | Pleckstrin And Sec7 Domain Protein2 | | MGC112791 | | |
Export aliases for FBXL15 gene to outside databasesPrevious GC identifers: GC10P103843 GC10P104169 GC10P097813 |
Summaries for FBXL15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulatorof the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediatesubiquitination of SMURF2 and WWP2
|
Genomic Views for FBXL15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FBXL15 gene promoter: p53 NRSF form 1 Nkx2-5 NRSF form 2 PPAR-alpha Ik-2 HOXA5 Zic3 Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL15
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL15 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.32FBXL15 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P104178: view genomic region
(about GC identifiers)
Start:
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104,178,946 bp from pter |
End:
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104,182,893 bp from pter |
Size:
|
3,948 bases |
Orientation:
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plus strand |
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Proteins for FBXL15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 15 Size: 300 amino acids; 32998 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1and FBXL15
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12517.1;Type=Erroneous gene model prediction; Sequence=CAI12518.1; Type=Erroneous gene model prediction; Sequence=CAI12519.1;Type=Erroneous gene model prediction; Sequence=CAI12520.1; Type=Erroneous gene model prediction; Sequence=CAI12522.2;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1L4J8 B1AKX8 B1AKX9 B1AKY0 B1AKY1 C9JWA4 Q0D2Q3 Q49AL7 Q5JWA5Explore the universe of human proteins at neXtProt for FBXL15: NX_Q9H469
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H469 FBXL15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077302.3 ENSEMBL proteins: ENSP00000411435 ENSP00000392215 ENSP00000358972 ENSP00000405961 ENSP00000403646 ENSP00000224862 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- | | GO:0019005 | SCF ubiquitin ligase complex |
IDA | -- |
FBXL15 for ontologies About GeneDecksing
FBXL15 Antibody Products: Assay Products for FBXL15: |
Protein
Domains / Families for FBXL15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL15 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H469ProtoNet protein and cluster: Q9H469 UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469Similarity: Belongs to the FBXL15 familySimilarity: Contains 1 F-box domainSimilarity: Contains 5 LRR (leucine-rich) repeats |
Function for FBXL15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex whichmediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulatorof the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediatesubiquitination of SMURF2 and WWP2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL15 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXL15 (NM_024326) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | contributes to ubiquitin-protein ligase activity |
IDA | -- | | GO:0005515 | protein binding |
IPI | -- |
FBXL15 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for FBXL15:
|
Pathways & Interactions for FBXL15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/32 Interacting proteins for FBXL15 (Q9H4692 ENSP000002248624) via UniProtKB, MINT, STRING, and/or I2D (see all 32) About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000086 | G2/M transition of mitotic cell cycle |
IMP | -- | | GO:0009953 | dorsal/ventral pattern formation |
ISS | -- | | GO:0016567 | protein ubiquitination |
IDA | -- | | GO:0030282 | bone mineralization |
ISS | -- | | GO:0030513 | positive regulation of BMP signaling pathway |
IMP | -- |
FBXL15 for ontologies About GeneDecksing
|
Drugs & Compounds for FBXL15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FBXL15 Search CenterWatch for drugs/clinical trials and news about FBXL15 / FXL15 
|
Transcripts for FBXL15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FBXL15 gene: NM_024326.3 Unigene Cluster for FBXL15: F-box and leucine-rich repeat protein 15 Hs.380081 [show with all ESTs]Unigene Representative Sequence: NM_0243267 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432590 ENST00000481808 ENST00000457067 ENST00000369956(uc001kvj.1 uc001kvl.1) ENST00000440407 ENST00000425536 ENST00000224862(uc001kvk.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL15 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL15 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXL15 (NM_024326) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15  |
Additional cDNA sequence: AK122684.1 BC002912.2 BC036120.1 BC130566.1 14 DOTS entries: DT.444008 DT.121252620 DT.97804713 DT.97844337 DT.91744689 DT.95338664 DT.91744694 DT.121252609 DT.75183986 DT.95124126 DT.99949070 DT.101981950 DT.121252574 DT.428527 24/160 AceView cDNA sequences (see all 160): H08374 BQ001207 CR616238 BI858979 BU630947 BM068724 BU730529 BQ447584 BM703242 BM921680 CR592302 AI638361 BU677737 CR595934 CA314694 BG257343 BM458776 BU633597 AI934376 CR614978 BM704366 BQ777226 BI088482 CR591228 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | |
| SP1: | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for FBXL15
|
Expression for FBXL15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL15 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGGCGGAGTC
About this image See FBXL15 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FBXL15
SOURCE GeneReport for Unigene cluster: Hs.380081 SABiosciences Expression via Pathway-Focused PCR Array including FBXL15:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL15 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL15 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL15 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL15 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15 |
Orthologs for FBXL15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FBXL15 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for FBXL15 (if available) TreeFam Gene Tree for FBXL15 (if available)  |
Paralogs for FBXL15 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FBXL15 gene
- FBXL172 FBXL22 FBXL202 ENSG000002371022 FBXL132 FBXL162 FBXL72 AMN12
- LRRC292 FBXL42 FBXL142
FBXL15 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FBXL15 PGOHUM00000258537
|
Genomic Variants for FBXL15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 10 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL15 (104178946 - 104182893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for FBXL15: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL15 |
|
Disorders
/ Diseases for FBXL15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXL15 for disorders About GeneDecksing
OMIM gene information: 610287
OMIM disorders: --
3 diseases for FBXL15: About MalaCardsyellow fever smallpox endocarditis 1 disease from the University of Copenhagen DISEASES database for FBXL15:Smallpox Export disorders for FBXL15 gene to outside databases
|
Publications for FBXL15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL15 gene integrated from 9 sources: (articles sorted by number of sources associating them with FBXL15) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)2 Cui Y.... Zhang L. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FBXL15 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FBXL15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FBXL15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL15 gene: Search GeneIP for patents involving FBXL15
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FBXL15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15 |
|  |  |  | | | ThermoFisher Antibody for FBXL15 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15 |
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