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Aliases for FBXL15 Gene

Aliases for FBXL15 Gene

  • F-Box And Leucine-Rich Repeat Protein 15 2 3
  • F-Box Only Protein 37 2 3 4
  • FBXO37 3 4
  • JET 3 6
  • Pleckstrin And Sec7 Domain Protein 3
  • F-Box/LRR-Repeat Protein 15 3
  • Fbl15 3
  • PSD 3

External Ids for FBXL15 Gene

Previous HGNC Symbols for FBXL15 Gene

  • FBXO37

Previous GeneCards Identifiers for FBXL15 Gene

  • GC10P103843
  • GC10P104169
  • GC10P097813
  • GC10P104178

Summaries for FBXL15 Gene

GeneCards Summary for FBXL15 Gene

FBXL15 (F-Box And Leucine-Rich Repeat Protein 15) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL15 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL15 Gene

Genomics for FBXL15 Gene

Regulatory Elements for FBXL15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL15 Gene

Start:
102,419,189 bp from pter
End:
102,423,137 bp from pter
Size:
3,949 bases
Orientation:
Plus strand

Genomic View for FBXL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL15 Gene

Proteins for FBXL15 Gene

  • Protein details for FBXL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H469-FXL15_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 15
    Protein Accession:
    Q9H469
    Secondary Accessions:
    • A1L4J8
    • B1AKX8
    • B1AKX9
    • B1AKY0
    • B1AKY1
    • C9JWA4
    • Q0D2Q3
    • Q49AL7
    • Q5JWA5

    Protein attributes for FBXL15 Gene

    Size:
    300 amino acids
    Molecular mass:
    32998 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
    SequenceCaution:
    • Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12519.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FBXL15 Gene

Proteomics data for FBXL15 Gene at MOPED

Post-translational modifications for FBXL15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL15 Gene

No data available for DME Specific Peptides for FBXL15 Gene

Domains for FBXL15 Gene

Gene Families for FBXL15 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H469

UniProtKB/Swiss-Prot:

FXL15_HUMAN :
  • Q9H469
Domain:
  • Contains 1 F-box domain.
Family:
  • Belongs to the FBXL15 family.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL15: view

Function for FBXL15 Gene

Molecular function for FBXL15 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Gene Ontology (GO) - Molecular Function for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 21572392
GO:0005515 protein binding IPI 21572392
genes like me logo Genes that share ontologies with FBXL15: view

Phenotypes for FBXL15 Gene

genes like me logo Genes that share phenotypes with FBXL15: view

Animal Model Products

CRISPR Products

miRNA for FBXL15 Gene

miRTarBase miRNAs that target FBXL15

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBXL15 Gene

Localization for FBXL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL15 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL15 Gene COMPARTMENTS Subcellular localization image for FBXL15 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21572392
GO:0019005 SCF ubiquitin ligase complex IDA 21572392
genes like me logo Genes that share ontologies with FBXL15: view

Pathways for FBXL15 Gene

SuperPathways for FBXL15 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with FBXL15: view

Pathways by source for FBXL15 Gene

1 KEGG pathway for FBXL15 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9H469-FXL15_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21572392
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0016567 protein ubiquitination IEA --
GO:0030282 bone mineralization ISS --
GO:0030513 positive regulation of BMP signaling pathway IMP 21572392
genes like me logo Genes that share ontologies with FBXL15: view

Transcripts for FBXL15 Gene

Unigene Clusters for FBXL15 Gene

F-box and leucine-rich repeat protein 15:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL15

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for FBXL15 Gene

GeneLoc Exon Structure for
FBXL15
ECgene alternative splicing isoforms for
FBXL15

Expression for FBXL15 Gene

mRNA expression in normal human tissues for FBXL15 Gene

Protein differential expression in normal tissues for FBXL15 Gene

This gene is overexpressed in Spinal cord (18.3), Frontal cortex (16.1), Retina (12.8), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL15 Gene

SOURCE GeneReport for Unigene cluster for FBXL15 Gene Hs.380081

genes like me logo Genes that share expressions with FBXL15: view

Expression partners for FBXL15 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL15 Gene

Orthologs for FBXL15 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL15 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FBXL15 35
  • 91.78 (n)
  • 96.67 (a)
FBXL15 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl15 35
  • 88.78 (n)
  • 96.33 (a)
Fbxl15 16
Fbxl15 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL15 35
  • 99.44 (n)
  • 99.67 (a)
FBXL15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl15 35
  • 88.89 (n)
  • 95.33 (a)
cow
(Bos Taurus)
Mammalia FBXL15 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL15 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL15 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL15 35
  • 67.5 (n)
  • 65.48 (a)
FBXL15 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL15 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl15 35
  • 59.56 (n)
  • 56.7 (a)
Str.20389 35
zebrafish
(Danio rerio)
Actinopterygii fbxl15 35
  • 64.77 (n)
  • 61.92 (a)
fbxl15 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009335 35
  • 47.85 (n)
  • 34.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta jet 35
  • 45.32 (n)
  • 32.02 (a)
jet 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for FBXL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL15 Gene

ENSEMBL:
Gene Tree for FBXL15 (if available)
TreeFam:
Gene Tree for FBXL15 (if available)

Paralogs for FBXL15 Gene

Paralogs for FBXL15 Gene

Pseudogenes.org Pseudogenes for FBXL15 Gene

genes like me logo Genes that share paralogs with FBXL15: view

Variants for FBXL15 Gene

Sequence variations from dbSNP and Humsavar for FBXL15 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs112459679 -- 102,422,718(+) AGTCC(A/G)AGGCT intron-variant
rs113633924 -- 102,422,042(+) TGGAC(A/G)GGCTG missense, reference
rs141296472 -- 102,422,433(+) AAGGG(C/T)CTCTA intron-variant
rs150204452 -- 102,422,485(+) TCAAC(C/T)AATGT intron-variant
rs201617141 -- 102,422,003(+) CACGC(C/T)TGCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FBXL15 Gene

Variant ID Type Subtype PubMed ID
nsv895970 CNV Loss 21882294
dgv814n71 CNV Loss 21882294

Relevant External Links for FBXL15 Gene

HapMap Linkage Disequilibrium report
FBXL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL15 Gene

Disorders for FBXL15 Gene

(1) University of Copenhagen DISEASES for FBXL15 Gene

genes like me logo Genes that share disorders with FBXL15: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for FBXL15 Gene

Publications for FBXL15 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PMID: 21572392) Cui Y. … Zhang L. (EMBO J. 2011) 3 4
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for FBXL15 Gene

Sources for FBXL15 Gene

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