Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBXL15 Gene

protein-coding   GIFtS: 46
GCID: GC10P104178

F-Box And Leucine-Rich Repeat Protein 15

(Previous name: F-box only protein 37)
(Previous symbol: FBXO37)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
F-Box And Leucine-Rich Repeat Protein 151 2     JET2
FBXO371 2 3     PSD2
F-Box Only Protein 371 2 3     F-Box/LRR-Repeat Protein 152
Fbl152     Pleckstrin And Sec7 Domain Protein2

External Ids:    HGNC: 281551   Entrez Gene: 791762   Ensembl: ENSG000001078727   OMIM: 6102875   UniProtKB: Q9H4693   

Export aliases for FBXL15 gene to outside databases

Previous GC identifers: GC10P103843 GC10P104169 GC10P097813


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FBXL15 Gene: 
FBXL15 (F-box and leucine-rich repeat protein 15) is a protein-coding gene. Diseases associated with FBXL15 include smallpox, and yellow fever. GO annotations related to this gene include ubiquitin-protein ligase activity and protein binding. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469
Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive
regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance.
Also mediates ubiquitination of SMURF2 and WWP2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBXL15 gene promoter:
         p53   NRSF form 1   Nkx2-5   NRSF form 2   PPAR-alpha   Ik-2   HOXA5   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FBXL15 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBXL15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.32

FBXL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBXL15 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104178:  view genomic region     (about GC identifiers)

Start:
104,178,946 bp from pter      End:
104,182,893 bp from pter
Size:
3,948 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469 (See protein sequence)
Recommended Name: F-box/LRR-repeat protein 15  
Size: 300 amino acids; 32998 Da
Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1,
RBX1 and FBXL15
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12517.1;
Type=Erroneous gene model prediction; Sequence=CAI12518.1; Type=Erroneous gene model prediction;
Sequence=CAI12519.1; Type=Erroneous gene model prediction; Sequence=CAI12520.1; Type=Erroneous gene model
prediction; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1L4J8 B1AKX8 B1AKX9 B1AKY0 B1AKY1 C9JWA4 Q0D2Q3 Q49AL7 Q5JWA5

Explore the universe of human proteins at neXtProt for FBXL15: NX_Q9H469

Explore proteomics data for FBXL15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H469

  • FBXL15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBXL15 Protein Expression
    REFSEQ proteins: NP_077302.3  
    ENSEMBL proteins: 
     ENSP00000411435   ENSP00000392215   ENSP00000358972   ENSP00000405961   ENSP00000403646  
     ENSP00000224862  

    Human Recombinant Protein Products for FBXL15: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for FBXL15
    GenScript Custom Purified and Recombinant Proteins Services for FBXL15
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FBXL15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0019005SCF ubiquitin ligase complex IDA--

    FBXL15 for ontologies           About GeneDecksing



    FBXL15 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FBXL15
    GenScript Custom Superior Antibodies Services for FBXL15
    Abcam antibodies for FBXL15
    Cloud-Clone Corp. Antibodies for FBXL15 
    ThermoFisher Antibody for FBXL15
    LSBio Antibodies in human, mouse, rat for FBXL15 

    Assay Products for FBXL15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FBXL15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FBXL15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FBXL15 
    Cloud-Clone Corp. CLIAs for FBXL15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FBXL: F-boxes / Leucine-rich repeats

    1 InterPro protein domain:
     IPR001810 F-box_dom_cyclin-like

    Graphical View of Domain Structure for InterPro Entry Q9H469

    ProtoNet protein and cluster: Q9H469

    UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469
    Similarity: Belongs to the FBXL15 family
    Similarity: Contains 1 F-box domain
    Similarity: Contains 5 LRR (leucine-rich) repeats


    FBXL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FXL15_HUMAN, Q9H469
    Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which
    mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive
    regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance.
    Also mediates ubiquitination of SMURF2 and WWP2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI--
         
    FBXL15 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for FBXL15:
     Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXL15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FBXL15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FBXL15 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL15
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXL15:
    hsa-miR-127-5p hsa-miR-455-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidFBXL15 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXL15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FBXL15
    Sirion Biotech Customized adenovirus for overexpression of FBXL15

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for FBXL15 (see all 7)
    OriGene ORF clones in mouse, rat for FBXL15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXL15 (NM_024326)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15
    Sirion Biotech Customized lentivirus for stable overexpression of FBXL15 
                         Customized lentivirus expression plasmids for stable overexpression of FBXL15 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FBXL15
    Search LifeMap BioReagents cell lines for FBXL15
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: FXL15_HUMAN, Q9H469
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for FBXL15 (Q9H4692 ENSP000002248624) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1Q9HCE72, ENSP000003546214MINT-8199952 MINT-8298454 MINT-8199931 MINT-8298316 MINT-8298472 MINT-8198843 STRING: ENSP00000354621
    SMURF2Q9HAU42, ENSP000002624354MINT-8200043 MINT-8298439 MINT-8297030 STRING: ENSP00000262435
    SKP1P632082, ENSP000002314874MINT-8198846 STRING: ENSP00000231487
    HECW1Q76N892, ENSP000003792284MINT-8298370 STRING: ENSP00000379228
    HECW2Q9P2P52, ENSP000002609834MINT-8298383 STRING: ENSP00000260983
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IMP--
    GO:0009953dorsal/ventral pattern formation ISS--
    GO:0016567protein ubiquitination IDA--
    GO:0030282bone mineralization ISS--
    GO:0030513positive regulation of BMP signaling pathway IMP--

    FBXL15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBXL15 (FXL15)

    Search CenterWatch for drugs/clinical trials and news about FBXL15 / FXL15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBXL15 gene: 
    NM_024326.3  

    Unigene Cluster for FBXL15:

    F-box and leucine-rich repeat protein 15
    Hs.380081  [show with all ESTs]
    Unigene Representative Sequence: NM_024326
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432590 ENST00000481808 ENST00000457067 ENST00000369956(uc001kvj.1 uc001kvl.1)
    ENST00000440407 ENST00000425536 ENST00000224862(uc001kvk.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FBXL15
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FBXL15:
    hsa-miR-127-5p hsa-miR-455-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidFBXL15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for FBXL15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL15
    Clone
    Products:
         
    OriGene clones in human, mouse for FBXL15 (see all 7)
    OriGene ORF clones in mouse, rat for FBXL15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FBXL15 (NM_024326)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FBXL15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15
    Sirion Biotech Customized lentivirus for stable overexpression of FBXL15 
                         Customized lentivirus expression plasmids for stable overexpression of FBXL15 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FBXL15
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL15

    Additional mRNA sequence: 

    AK122684.1 BC002912.2 BC036120.1 BC130566.1 

    15 DOTS entries:

    DT.444008  DT.121252620  DT.97804713  DT.97844337  DT.91744689  DT.95338664  DT.91744694  DT.121252609 
    DT.75183986  DT.95124126  DT.101981950  DT.99949070  DT.121252574  DT.428527  DT.86848037 

    24/160 AceView cDNA sequences (see all 160):

    BQ958249 BI963018 BQ086241 BQ945255 BU677737 BQ777226 BU730529 BG775574 
    CA314694 BQ637819 BU633597 BQ447584 CR591228 BM068724 BQ787928 CR626178 
    CR614978 BM703242 BG257343 BM921680 AI638361 CR601691 BM704366 CR592302 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b
    SP1:        -     -     -     -     -     -           -                                             
    SP2:                                                  -                                             
    SP3:                                                  -                                             
    SP4:                                      -           -                                             
    SP5:                          -     -     -           -                                             


    ECgene alternative splicing isoforms for FBXL15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBXL15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCGGAGTC
    FBXL15 Expression
    About this image


    See FBXL15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBXL15

    SOURCE GeneReport for Unigene cluster: Hs.380081
        SABiosciences Expression via Pathway-Focused PCR Array including FBXL15: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FBXL15
    OriGene qSTAR qPCR primer pairs in human, mouse for FBXL15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FBXL15 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbxl151 , 5 F-box and leucine-rich repeat protein 151, 5 88.78(n)1
    96.33(a)1
      19 (38.81 cM)5
    684311  NM_133694.21  NP_598455.21 
     463281845 
    chicken
    (Gallus gallus)
    Aves FBXL151 F-box and leucine-rich repeat protein 15 67.5(n)
    65.71(a)
      428951  XM_426506.2  XP_426506.2 
    lizard
    (Anolis carolinensis)
    Reptilia FBXL156
    --
    Uncharacterized protein
    56(a)
    22(a)
    1 ↔ 1
    possible ortholog
    GL343196.1(260320-272639)
    2(42934087-42939594)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203892 Transcribed sequence with weak similarity to protein more 70.13(n)    BX757424.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fbxl151 F-box and leucine-rich repeat protein 15 65(n)
    62.14(a)
      405878  NM_212942.1  NP_998107.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta jet1 jetlag 45.31(n)
    31.25(a)
      33705  NM_135036.2  NP_608880.2 


    ENSEMBL Gene Tree for FBXL15 (if available)
    TreeFam Gene Tree for FBXL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBXL15 gene
    FBXL22  FBXL172  FBXL202  ENSG000002371022  FBXL132  FBXL162  FBXL72  LRRC292  
    FBXL142  FBXL42  

    FBXL15 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FBXL15
    PGOHUM00000258537


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    7 SNPs in FBXL15 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016171411,2
    --104181760(+) CACGCC/TTGCAG 2 L syn10--------
    rs1136339241,2
    C--104181799(+) TGGACA/GGGCTG 2 R G mis10--------
    rs1412964721,2
    --104182190(+) AAGGGC/TCTCTA 1 -- int10--------
    rs1502044521,2
    --104182242(+) TCAACC/TAATGT 1 -- int10--------
    rs3708220161,2
    ----104181999(+) GAACTC/TCACCA 2 L syn10--------
    rs1124596791,2
    ----104182475(+) AGTCCG/AAGGCT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs3761471681,2
    ----104182052(+) CAGGTG/TCCTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for FBXL15 (104178946 - 104182893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FBXL15:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv814n71CNV Loss21882294
    nsv895970CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FBXL15
    DNA2.0 Custom Variant and Variant Library Synthesis for FBXL15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610287    OMIM disorders: --

    3 diseases for FBXL15:    About MalaCards
    smallpox    yellow fever    endocarditis

    1 disease from the University of Copenhagen DISEASES database for FBXL15:
    Smallpox

    FBXL15 for disorders           About GeneDecksing


    Export disorders for FBXL15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBXL15 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with FBXL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1, 2 Cui Y.... Zhang L. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    5. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (2009)
    9. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. (PubMed id 17463251)1 Busino L....Pagano M. (2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79176 HGNC: 28155 AceView: FBXL15 Ensembl:ENSG00000107872 euGenes: HUgn79176
    ECgene: FBXL15 H-InvDB: FBXL15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBXL15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBXL15 gene:
    Search GeneIP for patents involving FBXL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FBXL15  
     OriGene qPCR primer pairs and template standards for FBXL15   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FBXL15  
     OriGene qSTAR qPCR primer pairs in human, mouse for FBXL15   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FBXL15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FBXL15   OriGene Custom Protein Services for FBXL15  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBXL15
     QIAGEN SeqTarget long-range PCR primers for resequencing FBXL15
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL15
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBXL15
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL15
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL15
     GenScript Custom Purified and Recombinant Proteins Services for FBXL15 GenScript cDNA clones with any tag delivered in your preferred vector for FBXL15
     GenScript Custom Assay Services for FBXL15 GenScript Custom Superior Antibodies Services for FBXL15
     GenScript Custom overexpressing Cell Line Services for FBXL15 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in FBXL15 promoter
     Search Chromatin IP Primers for FBXL15
     RT2 qPCR Primer Assay in human, mouse, rat FBXL15
     Search GNC Networks for FBXL15
     SABiosciences PCR Arrays including human, mouse, rat FBXL15
     Search Tocris compounds for FBXL15 (FXL15)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Antibodies for FBXL15
     See all of Abcam's Antibodies, Kits and Proteins for FBXL15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for FBXL15
     Antibodies for FBXL15
     ELISAs for FBXL15
     CLIAs for FBXL15
     Search LifeMap BioReagents cell lines for FBXL15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL15
     SwitchGear 3'UTR luciferase reporter plasmids for FBXL15
     SwitchGear Promoter luciferase reporter plasmids for FBXL15
     ThermoFisher Antibody for FBXL15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL15
     inGenious Targeting Laboratory - Custom generated mouse model solutions for FBXL15
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FBXL15
    Customized:
     lentivirus for stable overexpression of FBXL15
     lentivirus expression plasmids for stable overexpression of FBXL15
     adenovirus for overexpression of FBXL15
     LSBio Antibodies in human, mouse, rat for FBXL15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FBXL15 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4