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Aliases for FBXL15 Gene

Aliases for FBXL15 Gene

  • F-Box And Leucine Rich Repeat Protein 15 2 3 5
  • F-Box Only Protein 37 2 3 4
  • FBXO37 3 4
  • Pleckstrin And Sec7 Domain Protein 3
  • F-Box/LRR-Repeat Protein 15 3
  • Fbl15 3
  • JET 3
  • PSD 3

External Ids for FBXL15 Gene

Previous HGNC Symbols for FBXL15 Gene

  • FBXO37

Previous GeneCards Identifiers for FBXL15 Gene

  • GC10P103843
  • GC10P104169
  • GC10P097813
  • GC10P104178

Summaries for FBXL15 Gene

GeneCards Summary for FBXL15 Gene

FBXL15 (F-Box And Leucine Rich Repeat Protein 15) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL20.

UniProtKB/Swiss-Prot for FBXL15 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL15 Gene

Genomics for FBXL15 Gene

Regulatory Elements for FBXL15 Gene

Enhancers for FBXL15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F102333 1.1 ENCODE 14.9 -84.3 -84315 1.5 ZNF639 ZNF362 ZNF280D SP3 ZNF7 ZEB1 ZNF335 FOSL1 HIC1 MAFF FBXL15 ELOVL3 GBF1 PITX3 NFKB2 NOLC1 PSD GC10P102289
GH10F102385 0.2 Ensembl 11.9 -33.7 -33661 0.8 ELF3 MAZ ARID4B CEBPB CEBPG GABPA RELA ZNF7 KAT8 ZNF121 FBXL15 PSD GBF1 PITX3 CUEDC2 MIR146B C10orf95 MFSD13A NOLC1 SUFU
GH10F102462 0.2 ENCODE 11.4 +44.5 44491 1.6 TBP HDAC1 ARID4B ZNF48 RARA KAT2B YY1 SCRT2 SMARCA5 USF2 MFSD13A MIR146B CUEDC2 PSD FBXL15 SUFU RNU6-43P NFKB2 ELOVL3 GC10P102468
GH10F102368 0.2 ENCODE 11.3 -50.8 -50793 0.2 SMARCC1 ESRRA CEBPB ZBTB8A JUND MAFF MLLT1 RCOR1 MAFK NFE2L2 FBXL15 PSD NFKB2 ELOVL3 C10orf95 MFSD13A GC10P102289
GH10F102467 0.6 Ensembl ENCODE 11.1 +49.8 49814 2.7 ARID1B KLF1 NR2F1 IKZF1 CEBPB ZNF600 ZBTB40 SPI1 GABPA MFSD13A MIR146B CUEDC2 SUFU NFKB2 RNU6-43P FBXL15 PSD ELOVL3 RPARP-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FBXL15 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL15 Gene

Chromosome:
10
Start:
102,419,061 bp from pter
End:
102,423,138 bp from pter
Size:
4,078 bases
Orientation:
Plus strand

Genomic View for FBXL15 Gene

Genes around FBXL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL15 Gene

Proteins for FBXL15 Gene

  • Protein details for FBXL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H469-FXL15_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 15
    Protein Accession:
    Q9H469
    Secondary Accessions:
    • A1L4J8
    • B1AKX8
    • B1AKX9
    • B1AKY0
    • B1AKY1
    • C9JWA4
    • Q0D2Q3
    • Q49AL7
    • Q5JWA5

    Protein attributes for FBXL15 Gene

    Size:
    300 amino acids
    Molecular mass:
    32998 Da
    Quaternary structure:
    • Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL15) composed of CUL1, SKP1, RBX1 and FBXL15.
    SequenceCaution:
    • Sequence=AAH02912.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH36120.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12519.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12520.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12522.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FBXL15 Gene

Post-translational modifications for FBXL15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL15 Gene

Domains & Families for FBXL15 Gene

Gene Families for FBXL15 Gene

Protein Domains for FBXL15 Gene

Suggested Antigen Peptide Sequences for FBXL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H469

UniProtKB/Swiss-Prot:

FXL15_HUMAN :
  • Contains 1 F-box domain.
  • Belongs to the FBXL15 family.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Family:
  • Belongs to the FBXL15 family.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL15: view

Function for FBXL15 Gene

Molecular function for FBXL15 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Gene Ontology (GO) - Molecular Function for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 21572392
GO:0005515 protein binding IPI 21572392
genes like me logo Genes that share ontologies with FBXL15: view
genes like me logo Genes that share phenotypes with FBXL15: view

Animal Model Products

miRNA for FBXL15 Gene

miRTarBase miRNAs that target FBXL15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL15 Gene

Localization for FBXL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL15 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL15 Gene COMPARTMENTS Subcellular localization image for FBXL15 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 21572392
GO:0019005 SCF ubiquitin ligase complex IDA 21572392
genes like me logo Genes that share ontologies with FBXL15: view

Pathways & Interactions for FBXL15 Gene

genes like me logo Genes that share pathways with FBXL15: view

UniProtKB/Swiss-Prot Q9H469-FXL15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IMP 21572392
GO:0009953 dorsal/ventral pattern formation ISS --
GO:0016567 protein ubiquitination IEA --
GO:0030282 bone mineralization IEA,ISS --
GO:0030513 positive regulation of BMP signaling pathway IMP 21572392
genes like me logo Genes that share ontologies with FBXL15: view

No data available for SIGNOR curated interactions for FBXL15 Gene

Transcripts for FBXL15 Gene

Unigene Clusters for FBXL15 Gene

F-box and leucine-rich repeat protein 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL15 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - -
SP6:
SP7: - -

Relevant External Links for FBXL15 Gene

GeneLoc Exon Structure for
FBXL15
ECgene alternative splicing isoforms for
FBXL15

Expression for FBXL15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXL15 Gene

Protein differential expression in normal tissues from HIPED for FBXL15 Gene

This gene is overexpressed in Spinal cord (18.3), Frontal cortex (16.1), Retina (12.8), and Peripheral blood mononuclear cells (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL15 Gene



Protein tissue co-expression partners for FBXL15 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL15 Gene:

FBXL15

SOURCE GeneReport for Unigene cluster for FBXL15 Gene:

Hs.380081
genes like me logo Genes that share expression patterns with FBXL15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL15 Gene

Orthologs for FBXL15 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL15 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia FBXL15 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL15 34 35
  • 91.78 (n)
rat
(Rattus norvegicus)
Mammalia Fbxl15 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Fbxl15 34 16 35
  • 88.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FBXL15 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL15 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL15 34 35
  • 67.5 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL15 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl15 34
  • 59.56 (n)
Str.20389 34
zebrafish
(Danio rerio)
Actinopterygii fbxl15 34 35
  • 64.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009335 34
  • 47.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta jet 34 35
  • 45.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for FBXL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL15 Gene

ENSEMBL:
Gene Tree for FBXL15 (if available)
TreeFam:
Gene Tree for FBXL15 (if available)

Paralogs for FBXL15 Gene

Paralogs for FBXL15 Gene

genes like me logo Genes that share paralogs with FBXL15: view

Variants for FBXL15 Gene

Sequence variations from dbSNP and Humsavar for FBXL15 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs111522958 -- 102,421,249(+) GCTGG(C/G)TCTGG intron-variant, upstream-variant-2KB
rs112051003 -- 102,418,588(+) AATGC(A/C)GGGGA intron-variant, upstream-variant-2KB
rs112459679 -- 102,422,718(+) AGTCC(A/G)AGGCT intron-variant
rs113562565 -- 102,417,517(+) CCCTA(C/T)AGTCT intron-variant, upstream-variant-2KB
rs113633924 -- 102,422,042(+) TGGAC(A/G)GGCTG upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FBXL15 Gene

Variant ID Type Subtype PubMed ID
nsv1159761 CNV deletion 26073780
nsv951006 CNV deletion 24416366

Variation tolerance for FBXL15 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL15 Gene

Disorders for FBXL15 Gene

Relevant External Links for FBXL15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL15

No disorders were found for FBXL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL15 Gene

Publications for FBXL15 Gene

  1. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PMID: 21572392) Cui Y. … Zhang L. (EMBO J. 2011) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for FBXL15 Gene

Sources for FBXL15 Gene

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