FBXL14 Gene
protein-coding GIFtS: 47
GCID: GC12M001675
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|
F-box and leucine-rich repeat protein 14
| |
Aliases
for FBXL14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 141 2 3 | | Fbl141 2 | | MGC401951 | | F-Box/LRR-Repeat Protein 142 | | FBL143 |
Export aliases for FBXL14 gene to outside databasesPrevious GC identifers: GC12M001546 GC12M001547 GC12M001549 |
Summaries
for FBXL14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL14:
Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FXL14_HUMAN, Q8N1E6Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligasecomplexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1
|
Genomic Views
for FBXL14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL14 gene promoter:
AhR MyoD C/EBPalpha Arnt c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.33 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33FBXL14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M001675: view genomic region
(about GC identifiers)
Start:
|
1,675,159 bp from pter |
End:
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1,703,331 bp from pter |
Size:
|
28,173 bases |
Orientation:
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minus strand |
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Proteins
for FBXL14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXL14_HUMAN, Q8N1E6 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 14 Size: 418 amino acids; 45886 Da
Subunit: Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (Bysimilarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in thesubstrate destruction motif D-S-G-X(2,3,4)-S
Subcellular location: CytoplasmExplore the universe of human proteins at neXtProt for FBXL14: NX_Q8N1E6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N1E6
FBXL14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689654.1
ENSEMBL proteins: ENSP00000344855
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
FBXL14 for ontologies About GeneDecksing
FBXL14 Antibody Products:
Assay Products for FBXL14: |
Protein
Domains /
Families
for FBXL14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N1E6ProtoNet protein and cluster: Q8N1E6 UniProtKB/Swiss-Prot: FXL14_HUMAN, Q8N1E6Similarity: Contains 1 F-box domainSimilarity: Contains 5 LRR (leucine-rich) repeats |
Function
for FBXL14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FXL14_HUMAN, Q8N1E6Function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligasecomplexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1Induction: Down-regulated by hypoxia
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FBXL14 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FBXL14:
|
Pathways & Interactions
for FBXL14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL14
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FBXL14 (Q8N1E63 ENSP000003448554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
IDA | 19955572 |
FBXL14 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXL14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL14
Search CenterWatch for drugs/clinical trials and news about FBXL14 / FXL14
|
Transcripts
for FBXL14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL14 gene: NM_152441.2 Unigene Cluster for FBXL14: F-box and leucine-rich repeat protein 14 Hs.367956 [show with all ESTs]Unigene Representative Sequence: BC0281322 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339235(uc001qjh.3) ENST00000543278
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL14 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AF007128.1 BC028132.1 5 DOTS entries: DT.214954 DT.214953 DT.100745704 DT.40225682 DT.99952826 24/130 AceView cDNA sequences (see all 130): AW025794 AW080424 BE219264 BQ694416 CB529640 AA218733 BM931440 AI033016 BM053046 BC028132 H70397 BU739424 AW299665 AI493281 NM_152441 BM474297 AA704702 AI458123 U25905 BM127496 AI472033 BU738298 CR589998 BU623062
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL14 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for FBXL14
|
Expression
for FBXL14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTAAAGA
About this image
See FBXL14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL14
SOURCE GeneReport for Unigene cluster: Hs.367956
SABiosciences Expression via Pathway-Focused PCR Array including FBXL14:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL14
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL14 |
Orthologs
for FBXL14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FBXL14 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for FBXL14 (if available)
TreeFam Gene Tree for FBXL14 (if available) |
Paralogs
for FBXL14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXL14 gene
- FBXL172 FBXL22 FBXL202 ENSG000002371022 FBXL132 FBXL162 FBXL72 AMN12
- LRRC292 FBXL152 FBXL42
1 SIMAP similar gene for FBXL14 using alignment to 1 protein entry: FXL14_HUMAN:FBXL2
FBXL14 for paralogs About GeneDecksing
|
Genomic Variants
for FBXL14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL14 (1675159 - 1703331 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBXL14
1 CNV: 71426 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL14 |
|
Disorders
/ Diseases
for FBXL14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBXL14 for disorders About GeneDecksing
OMIM gene information: 609081
OMIM disorders: --
1  disease for FBXL14: About MalaCardshypoxia
Export disorders for FBXL14 gene to outside databases
|
Publications
for FBXL14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FBXL14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The hypoxia-controlled FBXL14 ubiquitin ligase target s SNAIL1 for proteasome degradation. (PubMed id 19955572)1, 2 ViA+as-Castells R....DA-az V.M. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Systematic analysis and nomenclature of mammalian F-box proteins. (PubMed id 15520277)1 Jin J....Harper J.W. (2004)
|
External Searches for FBXL14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL14 gene:
Search GeneIP for patents involving FBXL14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL14 |
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