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Aliases for FBXL14 Gene

Aliases for FBXL14 Gene

  • F-Box And Leucine Rich Repeat Protein 14 2 3 5
  • Fbl14 3 4
  • F-Box And Leucine-Rich Repeat Protein 14 4
  • F-Box/LRR-Repeat Protein 14 3

External Ids for FBXL14 Gene

Previous GeneCards Identifiers for FBXL14 Gene

  • GC12M001546
  • GC12M001547
  • GC12M001549
  • GC12M001675

Summaries for FBXL14 Gene

Entrez Gene Summary for FBXL14 Gene

  • Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL14 Gene

FBXL14 (F-Box And Leucine Rich Repeat Protein 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL13.

UniProtKB/Swiss-Prot for FBXL14 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

Additional gene information for FBXL14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL14 Gene

Genomics for FBXL14 Gene

GeneHancer (GH) Regulatory Elements for FBXL14 Gene

Promoters and enhancers for FBXL14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I001589 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.8 771 7.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 FBXL14 GC12M001593 PIR54397 WNT5B RAD52 DCP1B
GH12I001616 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.9 -24.0 -24021 3.6 HDAC1 PKNOX1 ARNT FEZF1 BATF BCLAF1 IKZF2 RUNX3 ZEB2 SP1 FBXL14 ENSG00000250132 ERC1 RAD52 MIR3649 WNT5B
GH12I001992 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -400.2 -400192 3.2 FOXA2 ARID4B IRF4 YY1 FOS RUNX3 RXRA JUNB REST KAT8 CBX3P4 ITFG2-AS1 LINC00942 TULP3 ITFG2 IQSEC3P1 DCP1B FBXL14 GC12M001963 CACNA1C
GH12I001562 Enhancer 0.7 dbSUPER 5.9 +30.7 30688 2.4 ZFP64 ZNF140 ZNF266 ZNF697 ZNF213 ZNF680 ZBTB11 ZC3H11A ZBTB8A REST RAD52 DCP1B ENSG00000250132 WNT5B ERC1 ENSG00000249028 FBXL14 PIR54620 PIR54397 GC12M001593
GH12I001591 Enhancer 0.5 FANTOM5 dbSUPER 3.1 +4.7 4731 0.1 WNT5B FBXL14 GC12M001593 PIR54397 PIR54620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FBXL14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FBXL14 gene promoter:

Genomic Locations for FBXL14 Gene

Genomic Locations for FBXL14 Gene
28,188 bases
Minus strand

Genomic View for FBXL14 Gene

Genes around FBXL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL14 Gene

Proteins for FBXL14 Gene

  • Protein details for FBXL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 14
    Protein Accession:

    Protein attributes for FBXL14 Gene

    418 amino acids
    Molecular mass:
    45886 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.

neXtProt entry for FBXL14 Gene

Post-translational modifications for FBXL14 Gene

No Post-translational modifications

Other Protein References for FBXL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL14 Gene

Domains & Families for FBXL14 Gene

Gene Families for FBXL14 Gene

Suggested Antigen Peptide Sequences for FBXL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL14: view

No data available for UniProtKB/Swiss-Prot for FBXL14 Gene

Function for FBXL14 Gene

Molecular function for FBXL14 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
UniProtKB/Swiss-Prot Induction:
Down-regulated by hypoxia.

Phenotypes From GWAS Catalog for FBXL14 Gene

Gene Ontology (GO) - Molecular Function for FBXL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19955572
genes like me logo Genes that share ontologies with FBXL14: view

Phenotypes for FBXL14 Gene

genes like me logo Genes that share phenotypes with FBXL14: view

miRNA for FBXL14 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL14 Gene

Localization for FBXL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL14 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL14 gene
Compartment Confidence
cytosol 5
nucleus 2
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FBXL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19955572
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL14: view

Pathways & Interactions for FBXL14 Gene

genes like me logo Genes that share pathways with FBXL14: view

Gene Ontology (GO) - Biological Process for FBXL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 19955572
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL14: view

No data available for SIGNOR curated interactions for FBXL14 Gene

Drugs & Compounds for FBXL14 Gene

No Compound Related Data Available

Transcripts for FBXL14 Gene

mRNA/cDNA for FBXL14 Gene

Unigene Clusters for FBXL14 Gene

F-box and leucine-rich repeat protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FBXL14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL14 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBXL14 Gene:


SOURCE GeneReport for Unigene cluster for FBXL14 Gene:


Evidence on tissue expression from TISSUES for FBXL14 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with FBXL14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL14 Gene

Orthologs for FBXL14 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL14 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia FBXL14 34
  • 100 (a)
(Pan troglodytes)
Mammalia FBXL14 33 34
  • 99.32 (n)
(Canis familiaris)
Mammalia FBXL14 33 34
  • 95.23 (n)
(Bos Taurus)
Mammalia FBXL14 33 34
  • 94.72 (n)
(Mus musculus)
Mammalia Fbxl14 33 16 34
  • 94.47 (n)
(Rattus norvegicus)
Mammalia Fbxl14 33
  • 94.39 (n)
(Gallus gallus)
Aves FBXL14 33
  • 87.78 (n)
(Anolis carolinensis)
Reptilia FBXL14 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl14 33
  • 85.68 (n)
(Danio rerio)
Actinopterygii fbxl14b 33 34
  • 79.82 (n)
ppab 33
fruit fly
(Drosophila melanogaster)
Insecta ppa 33 34
  • 62.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010289 33
  • 58.89 (n)
Species where no ortholog for FBXL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL14 Gene

Gene Tree for FBXL14 (if available)
Gene Tree for FBXL14 (if available)

Paralogs for FBXL14 Gene

Paralogs for FBXL14 Gene

(1) SIMAP similar genes for FBXL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FBXL14: view

Variants for FBXL14 Gene

Sequence variations from dbSNP and Humsavar for FBXL14 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000089218 -- 1,573,825(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000112145 -- 1,579,413(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000150728 -- 1,595,150(-) C/T upstream_transcript_variant
rs1000163375 -- 1,590,958(-) T/C intron_variant
rs1000276173 -- 1,568,687(-) CCCCCC/CCCCCCC genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL14 Gene

Variant ID Type Subtype PubMed ID
dgv2269n54 CNV loss 21841781
dgv2270n54 CNV loss 21841781
dgv2271n54 CNV gain 21841781
dgv2272n54 CNV gain+loss 21841781
dgv257n67 CNV gain 20364138
esv1091719 CNV insertion 17803354
esv1766777 CNV insertion 17803354
esv2658521 CNV deletion 23128226
esv2762959 CNV gain 21179565
esv27885 CNV loss 19812545
esv3628286 CNV loss 21293372
nsv1070500 CNV deletion 25765185
nsv470258 CNV gain 18288195
nsv556979 CNV loss 21841781
nsv556981 CNV gain+loss 21841781
nsv556986 CNV loss 21841781
nsv556990 CNV gain+loss 21841781
nsv556992 CNV gain 21841781
nsv556993 CNV loss 21841781

Variation tolerance for FBXL14 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FBXL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL14 Gene

Disorders for FBXL14 Gene

Additional Disease Information for FBXL14

No disorders were found for FBXL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL14 Gene

Publications for FBXL14 Gene

  1. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. (PMID: 19955572) Viñas-Castells R … Díaz VM (The Journal of biological chemistry 2010) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination. (PMID: 27923907) Fang X … Bao S (The Journal of experimental medicine 2017) 3 58

Products for FBXL14 Gene

Sources for FBXL14 Gene

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