Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXL14 Gene

Aliases for FBXL14 Gene

  • F-Box And Leucine Rich Repeat Protein 14 2 3 5
  • Fbl14 3 4
  • F-Box And Leucine-Rich Repeat Protein 14 4
  • F-Box/LRR-Repeat Protein 14 3

External Ids for FBXL14 Gene

Previous GeneCards Identifiers for FBXL14 Gene

  • GC12M001546
  • GC12M001547
  • GC12M001549
  • GC12M001675

Summaries for FBXL14 Gene

Entrez Gene Summary for FBXL14 Gene

  • Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL14 Gene

FBXL14 (F-Box And Leucine Rich Repeat Protein 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot for FBXL14 Gene

  • Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL14 Gene

Genomics for FBXL14 Gene

Regulatory Elements for FBXL14 Gene

Enhancers for FBXL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G001616 1.4 Ensembl ENCODE dbSUPER 12.9 -24.0 -24021 3.6 HDAC1 PKNOX1 FOXA2 TBL1XR1 ARNT FEZF1 EGR1 FOS IKZF2 ZEB2 FBXL14 ENSG00000250132 ERC1 RAD52 MIR3649
GH12G001992 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -400.2 -400192 3.2 FOXA2 ARID4B YY1 FOS JUNB KAT8 ETV4 HNF4A ZNF112 CTCF DCP1B FBXL14 GC12M001963
GH12G001562 0.7 dbSUPER 5.9 +30.7 30688 2.4 ZFP64 ZNF140 ZNF266 ZNF101 ZNF697 ZNF680 ZNF426 REST ZBTB8A ZNF394 ENSG00000250132 WNT5B ERC1 RAD52 ENSG00000249028 FBXL14 PIR54620 GC12M001593 PIR54397
GH12G001591 0.9 FANTOM5 dbSUPER 3.1 +4.7 4731 0.1 PRDM6 RNF2 NR2F1 NR2F6 WNT5B FBXL14 GC12M001593 PIR54397 PIR54620
GH12G001589 1.7 FANTOM5 ENCODE dbSUPER 0.7 +0.8 771 7.3 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 WNT5B FBXL14 GC12M001593 PIR54397
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL14 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047692 -320 1801 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF143
ENSR00000266783 1780 801 HDGF PKNOX1 FEZF1 ZNF2 GLIS2 KLF7 ZNF263 SP3 YY2 REST

Genomic Location for FBXL14 Gene

Chromosome:
12
Start:
1,565,993 bp from pter
End:
1,594,180 bp from pter
Size:
28,188 bases
Orientation:
Minus strand

Genomic View for FBXL14 Gene

Genes around FBXL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL14 Gene

Proteins for FBXL14 Gene

  • Protein details for FBXL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1E6-FXL14_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 14
    Protein Accession:
    Q8N1E6

    Protein attributes for FBXL14 Gene

    Size:
    418 amino acids
    Molecular mass:
    45886 Da
    Quaternary structure:
    • Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.

neXtProt entry for FBXL14 Gene

Post-translational modifications for FBXL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBXL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBXL14 Gene

Domains & Families for FBXL14 Gene

Gene Families for FBXL14 Gene

Protein Domains for FBXL14 Gene

Suggested Antigen Peptide Sequences for FBXL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL14: view

No data available for UniProtKB/Swiss-Prot for FBXL14 Gene

Function for FBXL14 Gene

Molecular function for FBXL14 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
UniProtKB/Swiss-Prot Induction:
Down-regulated by hypoxia.

Gene Ontology (GO) - Molecular Function for FBXL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS,IDA --
GO:0005515 protein binding IPI 19955572
genes like me logo Genes that share ontologies with FBXL14: view

Phenotypes for FBXL14 Gene

genes like me logo Genes that share phenotypes with FBXL14: view

Animal Model Products

CRISPR Products

miRNA for FBXL14 Gene

miRTarBase miRNAs that target FBXL14

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL14 Gene

Localization for FBXL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBXL14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL14 gene
Compartment Confidence
cytosol 5
nucleus 2
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19955572
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL14: view

Pathways & Interactions for FBXL14 Gene

genes like me logo Genes that share pathways with FBXL14: view

Gene Ontology (GO) - Biological Process for FBXL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 19955572
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL14: view

No data available for SIGNOR curated interactions for FBXL14 Gene

Drugs & Compounds for FBXL14 Gene

No Compound Related Data Available

Transcripts for FBXL14 Gene

mRNA/cDNA for FBXL14 Gene

Unigene Clusters for FBXL14 Gene

F-box and leucine-rich repeat protein 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b
SP1: -
SP2: - -
SP3: -

Relevant External Links for FBXL14 Gene

GeneLoc Exon Structure for
FBXL14
ECgene alternative splicing isoforms for
FBXL14

Expression for FBXL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL14 Gene



NURSA nuclear receptor signaling pathways regulating expression of FBXL14 Gene:

FBXL14

SOURCE GeneReport for Unigene cluster for FBXL14 Gene:

Hs.367956

Evidence on tissue expression from TISSUES for FBXL14 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with FBXL14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL14 Gene

Orthologs for FBXL14 Gene

This gene was present in the common ancestor of animals.

Orthologs for FBXL14 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia FBXL14 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL14 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia FBXL14 34 35
  • 95.23 (n)
cow
(Bos Taurus)
Mammalia FBXL14 34 35
  • 94.72 (n)
mouse
(Mus musculus)
Mammalia Fbxl14 34 16 35
  • 94.47 (n)
rat
(Rattus norvegicus)
Mammalia Fbxl14 34
  • 94.39 (n)
chicken
(Gallus gallus)
Aves FBXL14 34
  • 87.78 (n)
lizard
(Anolis carolinensis)
Reptilia FBXL14 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl14 34
  • 85.68 (n)
zebrafish
(Danio rerio)
Actinopterygii fbxl14b 34 35
  • 79.82 (n)
ppab 34
fruit fly
(Drosophila melanogaster)
Insecta ppa 34 35
  • 62.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010289 34
  • 58.89 (n)
Species where no ortholog for FBXL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL14 Gene

ENSEMBL:
Gene Tree for FBXL14 (if available)
TreeFam:
Gene Tree for FBXL14 (if available)

Paralogs for FBXL14 Gene

Paralogs for FBXL14 Gene

(1) SIMAP similar genes for FBXL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FBXL14: view

Variants for FBXL14 Gene

Sequence variations from dbSNP and Humsavar for FBXL14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000089218 -- 1,573,825(+) CATGG(A/T)GAAAC intron-variant
rs1000112145 -- 1,579,413(+) GAGTT(C/G)AAGAC intron-variant
rs1000150728 -- 1,595,150(+) ACACC(C/T)CTCTC upstream-variant-2KB
rs1000163375 -- 1,590,958(+) TTTCT(C/T)GCCCA intron-variant
rs1000276173 -- 1,568,686(+) TGAAA(-/C)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL14 Gene

Variant ID Type Subtype PubMed ID
dgv2269n54 CNV loss 21841781
dgv2270n54 CNV loss 21841781
dgv2271n54 CNV gain 21841781
dgv2272n54 CNV gain+loss 21841781
dgv257n67 CNV gain 20364138
esv1091719 CNV insertion 17803354
esv1766777 CNV insertion 17803354
esv2658521 CNV deletion 23128226
esv2762959 CNV gain 21179565
esv27885 CNV loss 19812545
esv3628286 CNV loss 21293372
nsv1070500 CNV deletion 25765185
nsv470258 CNV gain 18288195
nsv556979 CNV loss 21841781
nsv556981 CNV gain+loss 21841781
nsv556986 CNV loss 21841781
nsv556990 CNV gain+loss 21841781
nsv556992 CNV gain 21841781
nsv556993 CNV loss 21841781

Variation tolerance for FBXL14 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBXL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL14 Gene

Disorders for FBXL14 Gene

Relevant External Links for FBXL14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL14

No disorders were found for FBXL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL14 Gene

Publications for FBXL14 Gene

  1. The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. (PMID: 19955572) Vinas-Castells R. … Diaz V.M. (J. Biol. Chem. 2010) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. (PMID: 25203322) Zheng H. … Kang Y. (Cancer Cell 2014) 3 64
  5. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3 64

Products for FBXL14 Gene

Sources for FBXL14 Gene

Content
Loading form....