Aliases for FBXL14 Gene
Aliases for FBXL14 Gene
External Ids for FBXL14 Gene
- HGNC: 28624
- Entrez Gene: 144699
- Ensembl: ENSG00000171823
- OMIM: 609081
- UniProtKB: Q8N1E6
Previous GeneCards Identifiers for FBXL14 Gene
- GC12M001546
- GC12M001547
- GC12M001549
- GC12M001675
Summaries for FBXL14 Gene
-
Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXL14 Gene
FBXL14 (F-Box And Leucine Rich Repeat Protein 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is FBXL2.
UniProtKB/Swiss-Prot for FBXL14 Gene
-
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL14 Gene
Genomics for FBXL14 Gene
Regulatory Elements for FBXL14 Gene
Enhancers for FBXL14 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G001616 | 1.4 | Ensembl ENCODE dbSUPER | 12.9 | -24.0 | -24021 | 3.6 | HDAC1 PKNOX1 FOXA2 TBL1XR1 ARNT FEZF1 EGR1 FOS IKZF2 ZEB2 | FBXL14 RAD52 ERC1 ENSG00000250132 MIR3649 |
| GH12G001992 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 2.6 | -400.2 | -400192 | 3.2 | FOXA2 ARID4B YY1 FOS JUNB KAT8 ETV4 HNF4A ZNF112 CTCF | DCP1B FBXL14 GC12M001963 |
| GH12G001562 | 0.7 | dbSUPER | 5.9 | +30.7 | 30688 | 2.4 | ZFP64 ZNF140 ZNF266 ZNF101 ZNF697 ZNF680 ZNF426 REST ZBTB8A ZNF394 | ENSG00000250132 WNT5B ENSG00000249028 ERC1 RAD52 FBXL14 PIR54620 GC12M001593 PIR54397 |
| GH12G001591 | 0.9 | FANTOM5 dbSUPER | 3.1 | +4.7 | 4731 | 0.1 | PRDM6 RNF2 NR2F1 NR2F6 | WNT5B FBXL14 GC12M001593 PIR54397 PIR54620 |
| GH12G001589 | 1.7 | FANTOM5 ENCODE dbSUPER | 0.7 | +0.8 | 771 | 7.3 | HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 | WNT5B FBXL14 GC12M001593 PIR54397 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FBXL14 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FBXL14 gene promoter:
Regulatory Element Products
Genomic Location for FBXL14 Gene
- Chromosome:
- 12
- Start:
- 1,565,993 bp from pter
- End:
- 1,594,180 bp from pter
- Size:
- 28,188 bases
- Orientation:
- Minus strand
Genomic View for FBXL14 Gene
Genes around FBXL14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.33 by Ensembl
- 12p13.33 by Entrez Gene
- 12p13.33 by HGNC
FBXL14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL14 Gene
Proteins for FBXL14 Gene
-
Protein details for FBXL14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N1E6-FXL14_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 14
- Protein Accession:
- Q8N1E6
Protein attributes for FBXL14 Gene
- Size:
- 418 amino acids
- Molecular mass:
- 45886 Da
- Quaternary structure:
-
- Part of a SCF (SKP1-cullin-F-box) ubiquitin-protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Interacts with SNAI1; the interaction requires the phosphorylation of the two serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S.
Protein Expression for FBXL14 Gene
Post-translational modifications for FBXL14 Gene
Other Protein References for FBXL14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FBXL14
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- antibodies-online Antibodies for FBXL14: See all 28
- GeneTex FBXL14 antibody for FBXL14
Protein Products
-
OriGene Purified Proteins for FBXL14
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- antibodies-online Proteins for FBXL14: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL14
Assay Products
- antibodies-online Kits for FBXL14: See all 21
No data available for DME Specific Peptides for FBXL14 Gene
Domains & Families for FBXL14 Gene
Gene Families for FBXL14 Gene
Protein Domains for FBXL14 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL14 Gene
Function for FBXL14 Gene
Molecular function for FBXL14 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.
- UniProtKB/Swiss-Prot Induction:
- Down-regulated by hypoxia.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS,IDA | -- |
| GO:0005515 | protein binding | IPI | 19955572 |
Phenotypes for FBXL14 Gene
- GenomeRNAi human phenotypes for FBXL14:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL14 gene
-
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- Search ViGene Biosciences for FBXL14
CRISPR Products
-
OriGene CRISPR knockouts for FBXL14
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL14
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miRNA for FBXL14 Gene
- miRTarBase miRNAs that target FBXL14
miRNA Products
- Search ViGene Biosciences for FBXL14
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL14 gene
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-
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Cell Line Products
-
Horizon Cell Lines for FBXL14
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL14 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL14 Gene
Localization for FBXL14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FBXL14 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 2 |
| golgi apparatus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 19955572 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FBXL14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL14 Gene
4 Reactome pathways for FBXL14 Gene
Interacting Proteins for FBXL14 Gene
Selected Interacting proteins:
ENSP00000344855
Q8N1E6-FXL14_HUMAN
for FBXL14 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IDA | 19955572 |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL14 Gene
Transcripts for FBXL14 Gene
mRNA/cDNA for FBXL14 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (130) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL14
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL14
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miRNA Products
- Search ViGene Biosciences for FBXL14
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL14 gene
Clone Products
-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | - | |||||||||||
| SP3: | - |
Expression for FBXL14 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL14 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL14 Gene:
FBXL14SOURCE GeneReport for Unigene cluster for FBXL14 Gene:
Hs.367956Evidence on tissue expression from TISSUES for FBXL14 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for FBXL14
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL14 Gene
Orthologs for FBXL14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | FBXL14 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL14 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL14 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL14 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl14 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl14 34 |
|
||
| chicken (Gallus gallus) |
Aves | FBXL14 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL14 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl14 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fbxl14b 34 35 |
|
||
| ppab 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | ppa 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010289 34 |
|
- Species where no ortholog for FBXL14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL14 Gene
Variants for FBXL14 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000089218 | -- | 1,573,825(+) | CATGG(A/T)GAAAC | intron-variant | |
| rs1000112145 | -- | 1,579,413(+) | GAGTT(C/G)AAGAC | intron-variant | |
| rs1000150728 | -- | 1,595,150(+) | ACACC(C/T)CTCTC | upstream-variant-2KB | |
| rs1000163375 | -- | 1,590,958(+) | TTTCT(C/T)GCCCA | intron-variant | |
| rs1000276173 | -- | 1,568,686(+) | TGAAA(-/C)CCCCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2269n54 | CNV | loss | 21841781 |
| dgv2270n54 | CNV | loss | 21841781 |
| dgv2271n54 | CNV | gain | 21841781 |
| dgv2272n54 | CNV | gain+loss | 21841781 |
| dgv257n67 | CNV | gain | 20364138 |
| esv1091719 | CNV | insertion | 17803354 |
| esv1766777 | CNV | insertion | 17803354 |
| esv2658521 | CNV | deletion | 23128226 |
| esv2762959 | CNV | gain | 21179565 |
| esv27885 | CNV | loss | 19812545 |
| esv3628286 | CNV | loss | 21293372 |
| nsv1070500 | CNV | deletion | 25765185 |
| nsv470258 | CNV | gain | 18288195 |
| nsv556979 | CNV | loss | 21841781 |
| nsv556981 | CNV | gain+loss | 21841781 |
| nsv556986 | CNV | loss | 21841781 |
| nsv556990 | CNV | gain+loss | 21841781 |
| nsv556992 | CNV | gain | 21841781 |
| nsv556993 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.61% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FBXL14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL14 Gene
Disorders for FBXL14 Gene
Relevant External Links for FBXL14
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXL14
No disorders were found for FBXL14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL14 Gene
Publications for FBXL14 Gene
- The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. (PMID: 19955572) Vinas-Castells R. … Diaz V.M. (J. Biol. Chem. 2010) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. (PMID: 25203322) Zheng H. … Kang Y. (Cancer Cell 2014) 3 64
- Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3 64
Products for FBXL14 Gene
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- Custom Antibody ServicesOriGene Antibodies for FBXL14
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- antibodies-online Antibodies for FBXL14: See all 28
- antibodies-online Kits for FBXL14: See all 21
- antibodies-online Proteins for FBXL14: See all 4
- Search antibodies-online for peptides
- GeneTex FBXL14 antibody for FBXL14
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- VectorBuilder custom plasmid, inducible vectors for FBXL14
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer