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Aliases for FBXL13 Gene

Aliases for FBXL13 Gene

  • F-Box And Leucine-Rich Repeat Protein 13 2 3 4 5
  • Fbl13 3 4
  • DRC6 3

External Ids for FBXL13 Gene

Previous GeneCards Identifiers for FBXL13 Gene

  • GC07M102014
  • GC07M102047
  • GC07M102240
  • GC07M102453
  • GC07M096815
  • GC07M102812

Summaries for FBXL13 Gene

Entrez Gene Summary for FBXL13 Gene

  • Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL13 Gene

FBXL13 (F-Box And Leucine-Rich Repeat Protein 13) is a Protein Coding gene. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL13 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL13 Gene

Genomics for FBXL13 Gene

Regulatory Elements for FBXL13 Gene

Enhancers for FBXL13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBXL13 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL13 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL13 Gene

Chromosome:
7
Start:
102,700,062 bp from pter
End:
103,074,843 bp from pter
Size:
374,782 bases
Orientation:
Minus strand

Genomic View for FBXL13 Gene

Genes around FBXL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL13 Gene

Proteins for FBXL13 Gene

  • Protein details for FBXL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEE6-FXL13_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 13
    Protein Accession:
    Q8NEE6
    Secondary Accessions:
    • C9J565
    • C9J566
    • Q6UVW7
    • Q6UVW8
    • Q75MN5
    • Q86UJ5
    • Q8N7Y4
    • Q8TCL2
    • Q8WUF9
    • Q8WUG0

    Protein attributes for FBXL13 Gene

    Size:
    735 amino acids
    Molecular mass:
    83924 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=CAD28506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL13 Gene

Proteomics data for FBXL13 Gene at MOPED

Post-translational modifications for FBXL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL13 Gene

Domains & Families for FBXL13 Gene

Protein Domains for FBXL13 Gene

Suggested Antigen Peptide Sequences for FBXL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEE6

UniProtKB/Swiss-Prot:

FXL13_HUMAN :
  • Contains 1 F-box domain.
  • Contains 17 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 17 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL13: view

Function for FBXL13 Gene

Molecular function for FBXL13 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXL13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL13 Gene

Localization for FBXL13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL13 Gene COMPARTMENTS Subcellular localization image for FBXL13 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL13 Gene

Pathways & Interactions for FBXL13 Gene

SuperPathways for FBXL13 Gene

No Data Available

Interacting Proteins for FBXL13 Gene

Gene Ontology (GO) - Biological Process for FBXL13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXL13 Gene

Drugs & Compounds for FBXL13 Gene

No Compound Related Data Available

Transcripts for FBXL13 Gene

Unigene Clusters for FBXL13 Gene

F-box and leucine-rich repeat protein 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL13 Gene

No ASD Table

Relevant External Links for FBXL13 Gene

GeneLoc Exon Structure for
FBXL13
ECgene alternative splicing isoforms for
FBXL13

Expression for FBXL13 Gene

mRNA expression in normal human tissues for FBXL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL13 Gene

This gene is overexpressed in Testis (x15.8) and Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for FBXL13 Gene

This gene is overexpressed in Heart (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL13 Gene



SOURCE GeneReport for Unigene cluster for FBXL13 Gene Hs.660029

genes like me logo Genes that share expression patterns with FBXL13: view

Protein tissue co-expression partners for FBXL13 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXL13 Gene

Orthologs for FBXL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXL13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBXL13 35
  • 83.83 (n)
  • 75.14 (a)
FBXL13 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL13 35
  • 85.7 (n)
  • 77.87 (a)
FBXL13 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl13 35
  • 76.38 (n)
  • 68.62 (a)
Fbxl13 16
Fbxl13 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBXL13 35
  • 99.46 (n)
  • 99.05 (a)
FBXL13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl13 35
  • 76.05 (n)
  • 71.3 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXL13 36
  • 9 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL13 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBXL13 35
  • 61.08 (n)
  • 51.18 (a)
FBXL13 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL13 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl13 35
  • 58.29 (n)
  • 48.58 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883454 35
  • 51.66 (n)
  • 39.61 (a)
CR792430.3 36
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EBF1 35
  • 39.8 (n)
  • 27.36 (a)
rice
(Oryza sativa)
Liliopsida Os02g0200900 35
  • 40.87 (n)
  • 27.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for FBXL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL13 Gene

ENSEMBL:
Gene Tree for FBXL13 (if available)
TreeFam:
Gene Tree for FBXL13 (if available)

Paralogs for FBXL13 Gene

Paralogs for FBXL13 Gene

(1) SIMAP similar genes for FBXL13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL13: view

Variants for FBXL13 Gene

Sequence variations from dbSNP and Humsavar for FBXL13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs7805950 - 103,027,554(+) AATAG(A/C)ATATC nc-transcript-variant, reference, missense
VAR_031426 -
VAR_031427 -
VAR_031428 -
VAR_031429 -

Structural Variations from Database of Genomic Variants (DGV) for FBXL13 Gene

Variant ID Type Subtype PubMed ID
nsv469620 CNV Loss 16826518
esv2752138 CNV Loss 17911159
nsv470382 CNV Loss 18288195
nsv464667 CNV Loss 19166990
esv2494890 CNV Deletion 19546169
esv2177009 CNV Deletion 18987734
esv2734948 CNV Deletion 23290073
esv3724 CNV Deletion 18987735
nsv365999 CNV Loss 16902084
esv8670 CNV Loss 19470904
nsv5880 CNV Loss 18451855
esv2671890 CNV Deletion 23128226
esv273530 CNV Insertion 20981092
esv2452928 CNV Insertion 19546169
esv1748254 CNV Insertion 17803354
esv2657047 CNV Deletion 23128226
esv2734949 CNV Deletion 23290073
nsv5881 CNV Loss 18451855
esv27075 CNV Loss 19812545
esv2676324 CNV Deletion 23128226
nsv517148 CNV Loss 19592680
esv2734951 CNV Deletion 23290073
nsv526764 CNV Loss 19592680

Variation tolerance for FBXL13 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBXL13 Gene

Disorders for FBXL13 Gene

Relevant External Links for FBXL13

Genetic Association Database (GAD)
FBXL13
Human Genome Epidemiology (HuGE) Navigator
FBXL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL13

No disorders were found for FBXL13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL13 Gene

Publications for FBXL13 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3
  3. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. (PMID: 24165912) He J. … Gu D. (Circ Cardiovasc Genet 2013) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss N.P. … Shannon K.M. (Genomics 2005) 3

Products for FBXL13 Gene

Sources for FBXL13 Gene

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