Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FBXL13 Gene

Aliases for FBXL13 Gene

  • F-Box And Leucine Rich Repeat Protein 13 2 3 5
  • Fbl13 3 4
  • F-Box And Leucine-Rich Repeat Protein 13 4
  • F-Box/LRR-Repeat Protein 13 3
  • DRC6 3

External Ids for FBXL13 Gene

Previous GeneCards Identifiers for FBXL13 Gene

  • GC07M102014
  • GC07M102047
  • GC07M102240
  • GC07M102453
  • GC07M096815
  • GC07M102812

Summaries for FBXL13 Gene

Entrez Gene Summary for FBXL13 Gene

  • Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL13 Gene

FBXL13 (F-Box And Leucine Rich Repeat Protein 13) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is FBXL2.

UniProtKB/Swiss-Prot for FBXL13 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additional gene information for FBXL13 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL13 Gene

Genomics for FBXL13 Gene

Regulatory Elements for FBXL13 Gene

Enhancers for FBXL13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H102912 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +159.5 159536 6 ELF3 CTCF PKNOX1 JUN RAD21 ZNF316 ZNF366 ZNF547 PATZ1 FOS RNU6-1136P FBXL13 DPY19L2P2 ARMC10 LRRC17 RASA4 RPL23AP95 NFE4
GH07H102972 1.5 Ensembl ENCODE dbSUPER 10.4 +101.2 101215 3.2 HDGF PKNOX1 ATF1 ARNT YBX1 ZBTB7B ELK1 ATF7 CAVIN1 NCOA1 CRYZP1 ENSG00000213385 DNAJC2 PMPCB FBXL13 ARMC10 RPL23AP95 NFE4 GC07P103004
GH07H102811 0.9 FANTOM5 11 +262.9 262869 0.3 ELF3 SOX13 FOXA2 MAX RAD21 RARA YY1 ZNF316 GATA3 NR2F6 RNU6-1136P ARMC10 FBXL13 LOC100422696 GC07P102835
GH07H102812 0.8 Ensembl 11 +262.5 262543 0.2 ELF3 FOXA2 RAD21 RARA YY1 ZNF316 GATA3 POLR2A RCOR1 NR2F6 LRRC17 RNU6-1136P ARMC10 FBXL13 LOC100422696 GC07P102835
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBXL13 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216192 -357 2001 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SP3

Genomic Locations for FBXL13 Gene

Genomic Locations for FBXL13 Gene
374,782 bases
Minus strand

Genomic View for FBXL13 Gene

Genes around FBXL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL13 Gene

Proteins for FBXL13 Gene

  • Protein details for FBXL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 13
    Protein Accession:
    Secondary Accessions:
    • C9J565
    • C9J566
    • Q6UVW7
    • Q6UVW8
    • Q75MN5
    • Q86UJ5
    • Q8N7Y4
    • Q8TCL2
    • Q8WUF9
    • Q8WUG0

    Protein attributes for FBXL13 Gene

    735 amino acids
    Molecular mass:
    83924 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=CAD28506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL13 Gene


neXtProt entry for FBXL13 Gene

Post-translational modifications for FBXL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL13 Gene

Domains & Families for FBXL13 Gene

Protein Domains for FBXL13 Gene

Suggested Antigen Peptide Sequences for FBXL13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBXL13: view

No data available for UniProtKB/Swiss-Prot for FBXL13 Gene

Function for FBXL13 Gene

Molecular function for FBXL13 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Phenotypes From GWAS Catalog for FBXL13 Gene

Gene Ontology (GO) - Molecular Function for FBXL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with FBXL13: view
genes like me logo Genes that share phenotypes with FBXL13: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL13 Gene

Localization for FBXL13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBXL13 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FBXL13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FBXL13 Gene

Pathways & Interactions for FBXL13 Gene

genes like me logo Genes that share pathways with FBXL13: view

Gene Ontology (GO) - Biological Process for FBXL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with FBXL13: view

No data available for SIGNOR curated interactions for FBXL13 Gene

Drugs & Compounds for FBXL13 Gene

No Compound Related Data Available

Transcripts for FBXL13 Gene

Unigene Clusters for FBXL13 Gene

F-box and leucine-rich repeat protein 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL13 Gene

No ASD Table

Relevant External Links for FBXL13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBXL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL13 Gene

This gene is overexpressed in Testis (x15.8) and Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for FBXL13 Gene

This gene is overexpressed in Heart (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL13 Gene

Protein tissue co-expression partners for FBXL13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL13 Gene:


SOURCE GeneReport for Unigene cluster for FBXL13 Gene:


Evidence on tissue expression from TISSUES for FBXL13 Gene

  • Kidney(4.1)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FBXL13: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL13 Gene

Orthologs for FBXL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXL13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL13 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia FBXL13 33 34
  • 85.7 (n)
(Bos Taurus)
Mammalia FBXL13 33 34
  • 83.83 (n)
(Mus musculus)
Mammalia Fbxl13 33 16 34
  • 76.38 (n)
(Rattus norvegicus)
Mammalia Fbxl13 33
  • 76.05 (n)
(Ornithorhynchus anatinus)
Mammalia FBXL13 34
  • 54 (a)
(Monodelphis domestica)
Mammalia FBXL13 34
  • 9 (a)
(Gallus gallus)
Aves FBXL13 33 34
  • 61.08 (n)
(Anolis carolinensis)
Reptilia FBXL13 34
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl13 33
  • 58.29 (n)
(Danio rerio)
Actinopterygii LOC101883454 33
  • 51.66 (n)
CR792430.3 34
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EBF1 33
  • 39.8 (n)
(Oryza sativa)
Liliopsida Os02g0200900 33
  • 40.87 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for FBXL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL13 Gene

Gene Tree for FBXL13 (if available)
Gene Tree for FBXL13 (if available)

Paralogs for FBXL13 Gene

Paralogs for FBXL13 Gene

(1) SIMAP similar genes for FBXL13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL13: view

Variants for FBXL13 Gene

Sequence variations from dbSNP and Humsavar for FBXL13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000005866 -- 102,879,144(+) AGCAT(C/T)TCAGC intron-variant
rs1000007686 -- 102,922,871(+) TACTC(A/G)GGAGG intron-variant
rs1000044793 -- 103,016,059(+) AGAAT(C/T)AATAT intron-variant
rs1000046218 -- 102,903,600(+) CCCTA(A/G)TTTTT intron-variant
rs1000057988 -- 102,702,276(+) AACTC(-/TG)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL13 Gene

Variant ID Type Subtype PubMed ID
nsv5880 CNV deletion 18451855
nsv5881 CNV deletion 18451855
nsv608057 CNV loss 21841781
nsv608058 CNV gain 21841781
nsv608059 CNV loss 21841781
nsv608060 CNV loss 21841781
nsv957608 CNV deletion 24416366
nsv981564 CNV duplication 23825009
nsv526764 CNV loss 19592680
nsv517148 CNV loss 19592680
nsv470382 CNV loss 18288195
nsv469620 CNV loss 16826518
nsv464667 CNV loss 19166990
nsv365999 CNV deletion 16902084
nsv1140831 CNV deletion 24896259
nsv1137277 CNV deletion 24896259
nsv1109907 CNV deletion 24896259
esv8670 CNV loss 19470904
esv3724 CNV loss 18987735
esv3614367 CNV loss 21293372
esv3614366 CNV loss 21293372
esv3614365 CNV loss 21293372
esv3614364 CNV loss 21293372
esv3614362 CNV loss 21293372
esv3614361 CNV loss 21293372
esv3614358 CNV gain 21293372
esv3542193 CNV deletion 23714750
esv3447330 CNV duplication 20981092
esv3386647 CNV insertion 20981092
esv2761100 CNV gain+loss 21179565
esv2752138 CNV loss 17911159
esv2734951 CNV deletion 23290073
esv2734949 CNV deletion 23290073
esv2734948 CNV deletion 23290073
esv27075 CNV loss 19812545
esv2676324 CNV deletion 23128226
esv2671890 CNV deletion 23128226
esv2657047 CNV deletion 23128226
esv2494890 CNV deletion 19546169
esv2452928 CNV insertion 19546169
esv2177009 CNV deletion 18987734
esv1748254 CNV insertion 17803354
dgv6538n100 CNV gain 25217958

Variation tolerance for FBXL13 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL13 Gene

Disorders for FBXL13 Gene

Relevant External Links for FBXL13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL13 Gene

Publications for FBXL13 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss NP … Shannon KM (Genomics 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60

Products for FBXL13 Gene

Sources for FBXL13 Gene

Loading form....