Aliases for FBXL13 Gene
Aliases for FBXL13 Gene
External Ids for FBXL13 Gene
- HGNC: 21658
- Entrez Gene: 222235
- Ensembl: ENSG00000161040
- OMIM: 609080
- UniProtKB: Q8NEE6
Previous GeneCards Identifiers for FBXL13 Gene
- GC07M102014
- GC07M102047
- GC07M102240
- GC07M102453
- GC07M096815
- GC07M102812
Summaries for FBXL13 Gene
-
Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXL13 Gene
FBXL13 (F-Box And Leucine Rich Repeat Protein 13) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL2.
UniProtKB/Swiss-Prot for FBXL13 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL13 Gene
Genomics for FBXL13 Gene
Regulatory Elements for FBXL13 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G102912 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 10.9 | +159.5 | 159536 | 6.0 | ELF3 CTCF PKNOX1 JUN SIN3A RAD21 ZNF316 ZNF366 POLR2A ZNF547 | RNU6-1136P FBXL13 DPY19L2P2 ARMC10 LRRC17 RASA4 RPL23AP95 NFE4 |
| GH07G102972 | 1.6 | Ensembl ENCODE dbSUPER | 10.4 | +101.2 | 101215 | 3.2 | HDGF PKNOX1 CREB3L1 ARNT YBX1 ZBTB7B YY1 FOS KLF13 REST | FBXL13 ARMC10 RPL23AP95 NFE4 GC07P103004 |
| GH07G102748 | 1.1 | ENCODE | 13.1 | +325.8 | 325758 | 1.7 | HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 | POLR2J2 RASA4DP RASA4 ARMC10 FBXL13 POLR2J FAM185A RPL7AP39 |
| GH07G102931 | 1.1 | ENCODE | 10.7 | +142.9 | 142875 | 0.2 | CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF143 ZNF207 ZNF416 SP3 | FBXL13 LRRC17 NFE4 |
| GH07G102811 | 0.8 | FANTOM5 | 11 | +262.9 | 262869 | 0.3 | ELF3 SOX13 FOXA2 MAX RAD21 RARA YY1 ZNF121 ZNF316 GATA3 | RNU6-1136P ARMC10 FBXL13 LOC100422696 GC07P102835 |
- Transcription factor binding sites by QIAGEN in the FBXL13 gene promoter:
Regulatory Element Products
Genomic Location for FBXL13 Gene
- Chromosome:
- 7
- Start:
- 102,700,062 bp from pter
- End:
- 103,074,843 bp from pter
- Size:
- 374,782 bases
- Orientation:
- Minus strand
Genomic View for FBXL13 Gene
- Cytogenetic band:
-
- 7q22.1 by Ensembl
- 7q22.1 by Entrez Gene
- 7q22.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL13 Gene
Proteins for FBXL13 Gene
-
Protein details for FBXL13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEE6-FXL13_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 13
- Protein Accession:
- Q8NEE6
- C9J565
- C9J566
- Q6UVW7
- Q6UVW8
- Q75MN5
- Q86UJ5
- Q8N7Y4
- Q8TCL2
- Q8WUF9
- Q8WUG0
Protein attributes for FBXL13 Gene
- Size:
- 735 amino acids
- Molecular mass:
- 83924 Da
- Quaternary structure:
-
- Directly interacts with SKP1 and CUL1.
- SequenceCaution:
-
- Sequence=CAD28506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for FBXL13 Gene
Post-translational modifications for FBXL13 Gene
Other Protein References for FBXL13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL13
- Invitrogen Antibodies for FBXL13
- antibodies-online Antibodies for FBXL13: See all 27
- Search GeneTex for Antibodies for FBXL13
Protein Products
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- Novus Biologicals proteins for FBXL13
- antibodies-online Proteins for FBXL13: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL13
Assay Products
- antibodies-online Kits for FBXL13: See all 21
No data available for DME Specific Peptides for FBXL13 Gene
Domains & Families for FBXL13 Gene
Gene Families for FBXL13 Gene
Protein Domains for FBXL13 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL13 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL13 Gene
Function for FBXL13 Gene
Molecular function for FBXL13 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
Phenotypes for FBXL13 Gene
- GenomeRNAi human phenotypes for FBXL13:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Increased G1 DNA content
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Decreased viability with TRAIL
- Decreased viability after ionizing radiation
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL13 gene
-
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- Search ViGene Biosciences for FBXL13
CRISPR Products
-
OriGene CRISPR knockouts for FBXL13
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL13
- GenScript: Design CRISPR guide RNA sequences for FBXL13
miRNA for FBXL13 Gene
- miRTarBase miRNAs that target FBXL13
-
- hsa-mir-4477a (MIRT503916)
- hsa-mir-9-3p (MIRT503917)
- hsa-mir-590-5p (MIRT503918)
- hsa-mir-21-5p (MIRT503919)
- hsa-mir-4429 (MIRT503920)
- hsa-mir-320d (MIRT503921)
- hsa-mir-320c (MIRT503922)
- hsa-mir-320b (MIRT503923)
- hsa-mir-320a (MIRT503924)
- hsa-mir-548ay-3p (MIRT503925)
- hsa-mir-548at-3p (MIRT503926)
- hsa-mir-548as-3p (MIRT503927)
- hsa-mir-548t-3p (MIRT503928)
- hsa-mir-548ap-3p (MIRT503929)
- hsa-mir-548aa (MIRT503930)
- hsa-mir-548x-3p (MIRT503931)
- hsa-mir-548j-3p (MIRT503932)
- hsa-mir-548aq-3p (MIRT503933)
- hsa-mir-548am-3p (MIRT503934)
- hsa-mir-548aj-3p (MIRT503935)
- hsa-mir-548ah-3p (MIRT503936)
- hsa-mir-548ae-3p (MIRT503937)
- hsa-mir-548z (MIRT503938)
- hsa-mir-548h-3p (MIRT503939)
- hsa-mir-548d-3p (MIRT503940)
- hsa-mir-548bb-3p (MIRT503941)
- hsa-mir-548ac (MIRT503942)
- hsa-mir-5096 (MIRT515579)
- hsa-mir-3149 (MIRT515580)
- hsa-mir-6855-5p (MIRT515581)
- hsa-mir-3170 (MIRT515582)
- hsa-mir-3187-3p (MIRT515583)
- hsa-mir-4435 (MIRT515584)
- hsa-mir-588 (MIRT515585)
- hsa-mir-4701-5p (MIRT515586)
- hsa-mir-548s (MIRT515587)
- hsa-mir-197-3p (MIRT515588)
- hsa-mir-4775 (MIRT515589)
- hsa-mir-193b-5p (MIRT515590)
- hsa-mir-4755-3p (MIRT515591)
- hsa-mir-4735-5p (MIRT515592)
- hsa-mir-4716-5p (MIRT515593)
- hsa-mir-4781-3p (MIRT515594)
- hsa-mir-6890-5p (MIRT515595)
- hsa-mir-941 (MIRT515596)
- hsa-mir-590-3p (MIRT515597)
- hsa-mir-4662b (MIRT515598)
- hsa-mir-4647 (MIRT515599)
- hsa-mir-4426 (MIRT515600)
miRNA Products
- Search ViGene Biosciences for FBXL13
Inhibitory RNA Products
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-
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Horizon Cell Lines for FBXL13
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ViGene Biosciences adenoviral particle packaged cDNA for FBXL13 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL13 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL13 Gene
Localization for FBXL13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL13 Gene
Pathways & Interactions for FBXL13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL13 Gene
4 Reactome pathways for FBXL13 Gene
Interacting Proteins for FBXL13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL13 Gene
Transcripts for FBXL13 Gene
mRNA/cDNA for FBXL13 Gene
- (16) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (30) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL13 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL13
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL13
- GenScript: Design CRISPR guide RNA sequences for FBXL13
miRNA Products
- Search ViGene Biosciences for FBXL13
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL13
- Browse OriGene Inhibitory RNA Products For FBXL13
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL13 gene
Flow Cytometry Products
Expression for FBXL13 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for FBXL13 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL13 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL13 Gene:
FBXL13SOURCE GeneReport for Unigene cluster for FBXL13 Gene:
Hs.660029Evidence on tissue expression from TISSUES for FBXL13 Gene
- Kidney(4.1)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for FBXL13
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL13 Gene
Orthologs for FBXL13 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL13 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL13 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL13 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl13 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl13 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FBXL13 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FBXL13 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FBXL13 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL13 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl13 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101883454 34 |
|
||
| CR792430.3 35 |
|
OneToOne | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | EBF1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0200900 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for FBXL13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for FBXL13 Gene
Variants for FBXL13 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005866 | -- | 102,879,144(+) | AGCAT(C/T)TCAGC | intron-variant | |
| rs1000007686 | -- | 102,922,871(+) | TACTC(A/G)GGAGG | intron-variant | |
| rs1000044793 | -- | 103,016,059(+) | AGAAT(C/T)AATAT | intron-variant | |
| rs1000046218 | -- | 102,903,600(+) | CCCTA(A/G)TTTTT | intron-variant | |
| rs1000057988 | -- | 102,702,276(+) | AACTC(-/TG)TTTTT | intron-variant |
Relevant External Links for FBXL13 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL13
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL13 Gene
Disorders for FBXL13 Gene
Relevant External Links for FBXL13
No disorders were found for FBXL13 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL13 Gene
Publications for FBXL13 Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss N.P. … Shannon K.M. (Genomics 2005) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
Products for FBXL13 Gene
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- Novus Biologicals Antibodies for FBXL13
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- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FBXL13: See all 27
- antibodies-online Kits for FBXL13: See all 21
- antibodies-online Proteins for FBXL13: See all 6
- Search antibodies-online for peptides
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




