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Aliases for FBXL13 Gene

Aliases for FBXL13 Gene

  • F-Box And Leucine-Rich Repeat Protein 13 2 3 4
  • Fbl13 3 4 6
  • F-Box/LRR-Repeat Protein 13 3
  • EBXL13 6

External Ids for FBXL13 Gene

Previous GeneCards Identifiers for FBXL13 Gene

  • GC07M102014
  • GC07M102047
  • GC07M102240
  • GC07M102453
  • GC07M096815

Summaries for FBXL13 Gene

Entrez Gene Summary for FBXL13 Gene

  • Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL13 Gene

FBXL13 (F-Box And Leucine-Rich Repeat Protein 13) is a Protein Coding gene. An important paralog of this gene is FBXL16.

UniProtKB/Swiss-Prot for FBXL13 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL13 Gene

Genomics for FBXL13 Gene

Regulatory Elements for FBXL13 Gene

Genomic Location for FBXL13 Gene

Start:
102,812,861 bp from pter
End:
103,074,843 bp from pter
Size:
261,983 bases
Orientation:
Minus strand

Genomic View for FBXL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL13 Gene

Proteins for FBXL13 Gene

  • Protein details for FBXL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEE6-FXL13_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 13
    Protein Accession:
    Q8NEE6
    Secondary Accessions:
    • C9J565
    • C9J566
    • Q6UVW7
    • Q6UVW8
    • Q75MN5
    • Q86UJ5
    • Q8N7Y4
    • Q8TCL2
    • Q8WUF9
    • Q8WUG0

    Protein attributes for FBXL13 Gene

    Size:
    735 amino acids
    Molecular mass:
    83924 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    SequenceCaution:
    • Sequence=CAD28506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL13 Gene

Proteomics data for FBXL13 Gene at MOPED

Post-translational modifications for FBXL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL13 Gene

Domains for FBXL13 Gene

Gene Families for FBXL13 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL13 Gene

Suggested Antigen Peptide Sequences for FBXL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEE6

UniProtKB/Swiss-Prot:

FXL13_HUMAN :
  • Q8NEE6
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 17 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL13: view

Function for FBXL13 Gene

Molecular function for FBXL13 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Gene Ontology (GO) - Molecular Function for FBXL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with FBXL13: view

Phenotypes for FBXL13 Gene

genes like me logo Genes that share phenotypes with FBXL13: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXL13 Gene

Localization for FBXL13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL13 Gene COMPARTMENTS Subcellular localization image for FBXL13 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL13 Gene

Pathways for FBXL13 Gene

SuperPathways for FBXL13 Gene

No Data Available

Interacting Proteins for FBXL13 Gene

Gene Ontology (GO) - Biological Process for FBXL13 Gene

None

No data available for Pathways by source for FBXL13 Gene

Transcripts for FBXL13 Gene

Unigene Clusters for FBXL13 Gene

F-box and leucine-rich repeat protein 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL13 Gene

No ASD Table

Relevant External Links for FBXL13 Gene

GeneLoc Exon Structure for
FBXL13
ECgene alternative splicing isoforms for
FBXL13

Expression for FBXL13 Gene

mRNA expression in normal human tissues for FBXL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL13 Gene

This gene is overexpressed in Testis (15.8) and Whole Blood (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBXL13 Gene

SOURCE GeneReport for Unigene cluster for FBXL13 Gene Hs.660029

genes like me logo Genes that share expressions with FBXL13: view

No data available for mRNA Expression by UniProt/SwissProt for FBXL13 Gene

Orthologs for FBXL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL13 35
  • 99.46 (n)
  • 99.05 (a)
FBXL13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL13 35
  • 83.83 (n)
  • 75.14 (a)
FBXL13 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBXL13 35
  • 85.7 (n)
  • 77.87 (a)
FBXL13 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl13 35
  • 76.38 (n)
  • 68.62 (a)
Fbxl13 16
Fbxl13 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBXL13 36
  • 9 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBXL13 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl13 35
  • 76.05 (n)
  • 71.3 (a)
chicken
(Gallus gallus)
Aves FBXL13 35
  • 61.08 (n)
  • 51.18 (a)
FBXL13 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBXL13 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl13 35
  • 58.29 (n)
  • 48.58 (a)
zebrafish
(Danio rerio)
Actinopterygii CR792430.3 36
  • 33 (a)
OneToOne
LOC101883454 35
  • 51.66 (n)
  • 39.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EBF1 35
  • 39.8 (n)
  • 27.36 (a)
rice
(Oryza sativa)
Liliopsida Os02g0200900 35
  • 40.87 (n)
  • 27.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for FBXL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL13 Gene

ENSEMBL:
Gene Tree for FBXL13 (if available)
TreeFam:
Gene Tree for FBXL13 (if available)

Paralogs for FBXL13 Gene

Paralogs for FBXL13 Gene

Selected SIMAP similar genes for FBXL13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL13: view

Variants for FBXL13 Gene

Sequence variations from dbSNP and Humsavar for FBXL13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs847646 -- 102,907,532(+) gttct(C/T)actgt intron-variant
rs869332 -- 102,991,800(+) GTATG(A/G)TATGG intron-variant
rs917332 -- 102,876,145(+) CCTCA(C/T)AGGAT intron-variant
rs917333 -- 102,876,424(+) GACGA(C/T)ATGGA intron-variant
rs952879 -- 103,026,249(-) AGTCA(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBXL13 Gene

Variant ID Type Subtype PubMed ID
nsv469620 CNV Loss 16826518
esv2752138 CNV Loss 17911159
nsv470382 CNV Loss 18288195
nsv464667 CNV Loss 19166990
esv2494890 CNV Deletion 19546169
esv2177009 CNV Deletion 18987734
esv2734948 CNV Deletion 23290073
esv3724 CNV Deletion 18987735
nsv365999 CNV Loss 16902084
esv8670 CNV Loss 19470904
nsv5880 CNV Loss 18451855
esv2671890 CNV Deletion 23128226
esv273530 CNV Insertion 20981092
esv2452928 CNV Insertion 19546169
esv1748254 CNV Insertion 17803354
esv2657047 CNV Deletion 23128226
esv2734949 CNV Deletion 23290073
nsv5881 CNV Loss 18451855
esv27075 CNV Loss 19812545
esv2676324 CNV Deletion 23128226
nsv517148 CNV Loss 19592680
esv2734951 CNV Deletion 23290073
nsv526764 CNV Loss 19592680

Relevant External Links for FBXL13 Gene

HapMap Linkage Disequilibrium report
FBXL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL13 Gene

Disorders for FBXL13 Gene

Relevant External Links for FBXL13

Genetic Association Database (GAD)
FBXL13
Human Genome Epidemiology (HuGE) Navigator
FBXL13
genes like me logo Genes that share disorders with FBXL13: view

No data available for UniProtKB/Swiss-Prot for FBXL13 Gene

Publications for FBXL13 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss N.P. … Shannon K.M. (Genomics 2005) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FBXL13 Gene

Sources for FBXL13 Gene

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