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Aliases for FBXL13 Gene

Aliases for FBXL13 Gene

  • F-Box And Leucine Rich Repeat Protein 13 2 3 5
  • Fbl13 3 4
  • F-Box And Leucine-Rich Repeat Protein 13 4
  • F-Box/LRR-Repeat Protein 13 3
  • DRC6 3

External Ids for FBXL13 Gene

Previous GeneCards Identifiers for FBXL13 Gene

  • GC07M102014
  • GC07M102047
  • GC07M102240
  • GC07M102453
  • GC07M096815
  • GC07M102812

Summaries for FBXL13 Gene

Entrez Gene Summary for FBXL13 Gene

  • Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL13 Gene

FBXL13 (F-Box And Leucine Rich Repeat Protein 13) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is FBXL20.

UniProtKB/Swiss-Prot for FBXL13 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL13 Gene

Genomics for FBXL13 Gene

Regulatory Elements for FBXL13 Gene

Enhancers for FBXL13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F102811 0.4 FANTOM5 11 +262.9 262869 0.3 SOX13 ELF3 RAD21 RARA YY1 ZNF121 ZNF316 GATA3 NR2F6 MAFK RNU6-1136P ARMC10 FBXL13 LOC100422696 GC07P102835
GH07F102812 0.4 Ensembl 11 +262.4 262443 0.4 ELF3 RAD21 RARA YY1 ZNF121 ZNF316 GATA3 NR2F6 MAFK HOMEZ ARMC10 LRRC17 RNU6-1136P FBXL13 LOC100422696 GC07P102835
GH07F102912 1.3 FANTOM5 Ensembl ENCODE 10.9 +159.5 159536 6.0 ELF3 CTCF PKNOX1 JUN SIN3A RAD21 ZNF316 ZNF366 POLR2A PATZ1 RNU6-1136P FBXL13 DPY19L2P2 ARMC10 LRRC17 RASA4 RPL23AP95 NFE4
GH07F102931 0.4 ENCODE 10.7 +142.9 142875 0.2 CREB3L1 SIN3A FEZF1 ZNF2 ZNF143 ZNF416 ZNF207 SP3 REST ZFP41 CRYZP1 ENSG00000239486 ENSG00000236226 S100A11P1 PMPCB LRWD1 FAM185A SPDYE2 PRKRIP1 FBXL13
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FBXL13 on UCSC Golden Path with GeneCards custom track

Promoters for FBXL13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156179 -457 2601 HDGF ARID4B SIN3A DMAP1 ZNF2 ZNF143 KLF13 ZNF263 SP3 SP5

Genomic Location for FBXL13 Gene

102,700,062 bp from pter
103,074,843 bp from pter
374,782 bases
Minus strand

Genomic View for FBXL13 Gene

Genes around FBXL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL13 Gene

Proteins for FBXL13 Gene

  • Protein details for FBXL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 13
    Protein Accession:
    Secondary Accessions:
    • C9J565
    • C9J566
    • Q6UVW7
    • Q6UVW8
    • Q75MN5
    • Q86UJ5
    • Q8N7Y4
    • Q8TCL2
    • Q8WUF9
    • Q8WUG0

    Protein attributes for FBXL13 Gene

    735 amino acids
    Molecular mass:
    83924 Da
    Quaternary structure:
    • Directly interacts with SKP1 and CUL1.
    • Sequence=CAD28506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBXL13 Gene


neXtProt entry for FBXL13 Gene

Post-translational modifications for FBXL13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FBXL13 Gene

Domains & Families for FBXL13 Gene

Protein Domains for FBXL13 Gene

Suggested Antigen Peptide Sequences for FBXL13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 F-box domain.
  • Contains 17 LRR (leucine-rich) repeats.
  • Contains 1 F-box domain.
  • Contains 17 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL13: view

Function for FBXL13 Gene

Molecular function for FBXL13 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
genes like me logo Genes that share phenotypes with FBXL13: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBXL13 Gene

Localization for FBXL13 Gene

Subcellular locations from

Jensen Localization Image for FBXL13 Gene COMPARTMENTS Subcellular localization image for FBXL13 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL13 Gene

Pathways & Interactions for FBXL13 Gene

genes like me logo Genes that share pathways with FBXL13: view

Gene Ontology (GO) - Biological Process for FBXL13 Gene


No data available for SIGNOR curated interactions for FBXL13 Gene

Transcripts for FBXL13 Gene

Unigene Clusters for FBXL13 Gene

F-box and leucine-rich repeat protein 13:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL13 Gene

No ASD Table

Relevant External Links for FBXL13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FBXL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBXL13 Gene

This gene is overexpressed in Testis (x15.8) and Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for FBXL13 Gene

This gene is overexpressed in Heart (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBXL13 Gene

Protein tissue co-expression partners for FBXL13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBXL13 Gene:


SOURCE GeneReport for Unigene cluster for FBXL13 Gene:

genes like me logo Genes that share expression patterns with FBXL13: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for FBXL13 Gene

Orthologs for FBXL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBXL13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL13 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia FBXL13 34 35
  • 85.7 (n)
(Bos Taurus)
Mammalia FBXL13 34 35
  • 83.83 (n)
(Mus musculus)
Mammalia Fbxl13 34 16 35
  • 76.38 (n)
(Rattus norvegicus)
Mammalia Fbxl13 34
  • 76.05 (n)
(Ornithorhynchus anatinus)
Mammalia FBXL13 35
  • 54 (a)
(Monodelphis domestica)
Mammalia FBXL13 35
  • 9 (a)
(Gallus gallus)
Aves FBXL13 34 35
  • 61.08 (n)
(Anolis carolinensis)
Reptilia FBXL13 35
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl13 34
  • 58.29 (n)
(Danio rerio)
Actinopterygii LOC101883454 34
  • 51.66 (n)
CR792430.3 35
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EBF1 34
  • 39.8 (n)
(Oryza sativa)
Liliopsida Os02g0200900 34
  • 40.87 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
Species where no ortholog for FBXL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBXL13 Gene

Gene Tree for FBXL13 (if available)
Gene Tree for FBXL13 (if available)

Paralogs for FBXL13 Gene

Paralogs for FBXL13 Gene

(1) SIMAP similar genes for FBXL13 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FBXL13: view

Variants for FBXL13 Gene

Sequence variations from dbSNP and Humsavar for FBXL13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10046544 -- 102,912,636(+) TGTTG(C/T)ATTTT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs10156027 -- 102,917,716(+) CATGA(C/T)AGGAA intron-variant
rs10225238 -- 102,728,463(+) ccgca(A/T)gttct intron-variant
rs10225809 -- 102,732,090(+) tttta(C/T)atgga intron-variant
rs10225811 -- 102,975,267(+) tttcc(A/T)gaaga intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBXL13 Gene

Variant ID Type Subtype PubMed ID
dgv6538n100 CNV gain 25217958
esv1748254 CNV insertion 17803354
esv2177009 CNV deletion 18987734
esv2452928 CNV insertion 19546169
esv2494890 CNV deletion 19546169
esv2657047 CNV deletion 23128226
esv2671890 CNV deletion 23128226
esv2676324 CNV deletion 23128226
esv27075 CNV loss 19812545
esv2734948 CNV deletion 23290073
esv2734949 CNV deletion 23290073
esv2734951 CNV deletion 23290073
esv2752138 CNV loss 17911159
esv2761100 CNV gain+loss 21179565
esv3386647 CNV insertion 20981092
esv3447330 CNV duplication 20981092
esv3542193 CNV deletion 23714750
esv3614358 CNV gain 21293372
esv3614361 CNV loss 21293372
esv3614362 CNV loss 21293372
esv3614364 CNV loss 21293372
esv3614365 CNV loss 21293372
esv3614366 CNV loss 21293372
esv3614367 CNV loss 21293372
esv3724 CNV loss 18987735
esv8670 CNV loss 19470904
nsv1109907 CNV deletion 24896259
nsv1137277 CNV deletion 24896259
nsv1140831 CNV deletion 24896259
nsv365999 CNV deletion 16902084
nsv464667 CNV loss 19166990
nsv469620 CNV loss 16826518
nsv470382 CNV loss 18288195
nsv517148 CNV loss 19592680
nsv526764 CNV loss 19592680
nsv5880 CNV deletion 18451855
nsv5881 CNV deletion 18451855
nsv608057 CNV loss 21841781
nsv608058 CNV gain 21841781
nsv608059 CNV loss 21841781
nsv608060 CNV loss 21841781
nsv957608 CNV deletion 24416366
nsv981564 CNV duplication 23825009

Variation tolerance for FBXL13 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL13 Gene

Disorders for FBXL13 Gene

Relevant External Links for FBXL13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBXL13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL13 Gene

Publications for FBXL13 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss N.P. … Shannon K.M. (Genomics 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for FBXL13 Gene

Sources for FBXL13 Gene

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