FBXL12 Gene
protein-coding GIFtS: 46
GCID: GC19M009920
|
|
F-box and leucine-rich repeat protein 12
| |
Aliases
for FBXL12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| F-Box And Leucine-Rich Repeat Protein 121 2 3 | | Fbl121 2 | | F-Box Protein FBL122 3 | | FLJ201881 | | F-Box/LRR-Repeat Protein 122 | | FBL123 |
Export aliases for FBXL12 gene to outside databasesPrevious GC identifers: GC19M010042 GC19M010143 GC19M009766 GC19M009781 GC19M009501 |
Summaries
for FBXL12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBXL12:
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act asprotein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitinationtargets through other protein interaction domains (Jin et al., 2004 (PubMed 15520277)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: FXL12_HUMAN, Q9NXK8Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity)
|
Genomic Views
for FBXL12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBXL12 gene promoter:
CREB Elk-1 Pax-5 AP-1 deltaCREB ATF-2 STAT3 c-Jun LCR-F1 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBXL12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBXL12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2FBXL12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M009920: view genomic region
(about GC identifiers)
Start:
|
9,920,943 bp from pter |
End:
|
9,938,492 bp from pter |
Size:
|
17,550 bases |
Orientation:
|
minus strand |
|
Proteins
for FBXL12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXL12_HUMAN, Q9NXK8 (See
protein sequence)Recommended Name: F-box/LRR-repeat protein 12 Size: 326 amino acids; 37026 Da
Subunit: Interacts with SKP1 and CUL1 (By similarity)
Secondary accessions: B3KSJ8 Q9H5K4Alternative splicing: 2 isoforms: Q9NXK8-1 Q9NXK8-2 Explore the universe of human proteins at neXtProt for FBXL12: NX_Q9NXK8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXK8
FBXL12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060173.1
ENSEMBL proteins: ENSP00000467059 ENSP00000247977 ENSP00000464858 ENSP00000468033 ENSP00000467359 ENSP00000468369 ENSP00000468766 ENSP00000467523 ENSP00000464784 ENSP00000466142 ENSP00000467467 ENSP00000467859 ENSP00000465439
Human Recombinant Protein Products for FBXL12:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000151 | ubiquitin ligase complex |
IEA | -- | | GO:0005737 | cytoplasm |
IEA | -- |
FBXL12 for ontologies About GeneDecksing
FBXL12 Antibody Products:
Assay Products for FBXL12: |
Protein
Domains /
Families
for FBXL12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBXL12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NXK8ProtoNet protein and cluster: Q9NXK8 UniProtKB/Swiss-Prot: FXL12_HUMAN, Q9NXK8Similarity: Contains 1 F-box domainSimilarity: Contains 8 LRR (leucine-rich) repeats |
Function
for FBXL12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FXL12_HUMAN, Q9NXK8Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Bysimilarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
FBXL12 for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for FBXL12:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBXL12 (NM_017703) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL12 |
|
Pathways & Interactions
for FBXL12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBXL12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/18 Interacting proteins for FBXL12 (Q9NXK81, 2, 3 ENSP000002479774) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
FBXL12 for ontologies About GeneDecksing
|
Drugs & Compounds
for FBXL12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBXL12
Search CenterWatch for drugs/clinical trials and news about FBXL12 / FXL12
|
Transcripts
for FBXL12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBXL12 gene: NM_017703.1 Unigene Cluster for FBXL12: F-box and leucine-rich repeat protein 12 Hs.12439 [show with all ESTs]Unigene Representative Sequence: AK02700413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586651 ENST00000247977(uc002mmd.3 uc002mme.3 uc002mmf.3 uc002mmg.3)
ENST00000589626 ENST00000588922 ENST00000585379 ENST00000591009 ENST00000592732
ENST00000589438 ENST00000592067 ENST00000590808 ENST00000590277 ENST00000586469
ENST00000586073
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBXL12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBXL12 (NM_017703) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBXL12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL12 |
Additional cDNA sequence: AK000195.1 AK027004.1 AK093760.1 AL389936.1 BC001586.2 BX647073.1 9 DOTS entries: DT.85105459 DT.100817659 DT.101980743 DT.100817658 DT.121452456 DT.92426097 DT.95113281 DT.100788746 DT.100817655 24/174 AceView cDNA sequences (see all 174): AI498982 C00004 AI000819 F10789 CR610493 CR605677 CD672649 BU630139 Z42821 CR592319 AA991475 BI760557 BU730921 CA412595 CR626568 AI739350 BM547559 AI885126 CB991433 CR611669 CR614447 AW293474 BX396172 BP343492
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for FBXL12 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i | · | 6j |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBXL12
|
Expression
for FBXL12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBXL12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACCCACA
About this image
See FBXL12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBXL12
SOURCE GeneReport for Unigene cluster: Hs.12439
SABiosciences Expression via Pathway-Focused PCR Array including FBXL12:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBXL12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBXL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBXL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBXL12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL12 |
Orthologs
for FBXL12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FBXL12 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for FBXL12 (if available)
TreeFam Gene Tree for FBXL12 (if available) |
Paralogs
for FBXL12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBXL12 gene
FBXL12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FBXL12
PGOHUM00000240079
|
Genomic Variants
for FBXL12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBXL12 (9920943 - 9938492 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FBXL12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBXL12 |
|
Disorders
/ Diseases
for FBXL12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FBXL12 for disorders About MalaCards
FBXL12 for disorders About GeneDecksing
OMIM gene information: 609079
OMIM disorders: --
Export disorders for FBXL12 gene to outside databases
|
Publications
for FBXL12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBXL12 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with FBXL12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A family of mammalian F-box proteins. (PubMed id 10531037)1, 3 Winston J.T....Harper J.W. (1999)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
|
External Searches for FBXL12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBXL12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBXL12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBXL12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBXL12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBXL12 gene:
Search GeneIP for patents involving FBXL12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBXL12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | FBXL12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBXL12 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FBXL12 |
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