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Aliases for FBXL12 Gene

Aliases for FBXL12 Gene

  • F-Box And Leucine-Rich Repeat Protein 12 2 3 4 5
  • F-Box Protein FBL12 3 4
  • Fbl12 3 4

External Ids for FBXL12 Gene

Previous GeneCards Identifiers for FBXL12 Gene

  • GC19M010042
  • GC19M010143
  • GC19M009766
  • GC19M009781
  • GC19M009920
  • GC19M009501

Summaries for FBXL12 Gene

Entrez Gene Summary for FBXL12 Gene

  • Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL12 Gene

FBXL12 (F-Box And Leucine-Rich Repeat Protein 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL12 Gene

Genomics for FBXL12 Gene

Regulatory Elements for FBXL12 Gene

Promoters for FBXL12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBXL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for FBXL12 Gene

Chromosome:
19
Start:
9,810,267 bp from pter
End:
9,827,816 bp from pter
Size:
17,550 bases
Orientation:
Minus strand

Genomic View for FBXL12 Gene

Genes around FBXL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBXL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBXL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL12 Gene

Proteins for FBXL12 Gene

  • Protein details for FBXL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXK8-FXL12_HUMAN
    Recommended name:
    F-box/LRR-repeat protein 12
    Protein Accession:
    Q9NXK8
    Secondary Accessions:
    • B3KSJ8
    • Q9H5K4

    Protein attributes for FBXL12 Gene

    Size:
    326 amino acids
    Molecular mass:
    37026 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBXL12 Gene

Proteomics data for FBXL12 Gene at MOPED

Post-translational modifications for FBXL12 Gene

  • Ubiquitination at Lys 305
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for FBXL12 Gene

Domains & Families for FBXL12 Gene

Gene Families for FBXL12 Gene

Protein Domains for FBXL12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBXL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXK8

UniProtKB/Swiss-Prot:

FXL12_HUMAN :
  • Contains 1 F-box domain.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL12: view

Function for FBXL12 Gene

Molecular function for FBXL12 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
genes like me logo Genes that share phenotypes with FBXL12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL12 Gene

Localization for FBXL12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBXL12 Gene COMPARTMENTS Subcellular localization image for FBXL12 gene
Compartment Confidence
mitochondrion 3
cytosol 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBXL12 Gene

Pathways & Interactions for FBXL12 Gene

SuperPathways for FBXL12 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NXK8-FXL12_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for FBXL12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBXL12 Gene

Drugs & Compounds for FBXL12 Gene

No Compound Related Data Available

Transcripts for FBXL12 Gene

Unigene Clusters for FBXL12 Gene

F-box and leucine-rich repeat protein 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i · 6j
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11:

Relevant External Links for FBXL12 Gene

GeneLoc Exon Structure for
FBXL12
ECgene alternative splicing isoforms for
FBXL12

Expression for FBXL12 Gene

mRNA expression in normal human tissues for FBXL12 Gene

Protein differential expression in normal tissues from HIPED for FBXL12 Gene

This gene is overexpressed in Breast (30.0), Serum (18.7), and Bone (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL12 Gene



SOURCE GeneReport for Unigene cluster for FBXL12 Gene Hs.12439

genes like me logo Genes that share expression patterns with FBXL12: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FBXL12 Gene

Orthologs for FBXL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBXL12 35
  • 99.49 (n)
  • 100 (a)
FBXL12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBXL12 36
  • 94 (a)
OneToOne
FBXL12 35
  • 90.29 (n)
  • 94.48 (a)
dog
(Canis familiaris)
Mammalia FBXL12 35
  • 90.59 (n)
  • 96.01 (a)
FBXL12 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbxl12 16
Fbxl12 36
  • 93 (a)
OneToOne
Fbxl12 35
  • 86.61 (n)
  • 93.25 (a)
oppossum
(Monodelphis domestica)
Mammalia FBXL12 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbxl12 35
  • 86.08 (n)
  • 92.67 (a)
chicken
(Gallus gallus)
Aves LOC100859027 35
  • 53.08 (n)
  • 40.41 (a)
lizard
(Anolis carolinensis)
Reptilia FBXL12 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl12 35
  • 46.71 (n)
  • 39.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8417 36
  • 23 (a)
OneToOne
Species with no ortholog for FBXL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXL12 Gene

ENSEMBL:
Gene Tree for FBXL12 (if available)
TreeFam:
Gene Tree for FBXL12 (if available)

Paralogs for FBXL12 Gene

Pseudogenes.org Pseudogenes for FBXL12 Gene

genes like me logo Genes that share paralogs with FBXL12: view

No data available for Paralogs for FBXL12 Gene

Variants for FBXL12 Gene

Sequence variations from dbSNP and Humsavar for FBXL12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_064712 -
rs875338 -- 9,810,429(-) TACAC(A/G)CACGC utr-variant-3-prime
rs4044950 -- 9,812,778(+) AAAAA(-/AAA)CAACA intron-variant
rs10409695 -- 9,820,593(+) ACACA(C/T)ACACA upstream-variant-2KB
rs11880919 -- 9,810,663(+) tgatc(A/G)tcctt utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXL12 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV Loss 19592680
esv2669314 CNV Deletion 23128226

Variation tolerance for FBXL12 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBXL12 Gene

HapMap Linkage Disequilibrium report
FBXL12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL12 Gene

Disorders for FBXL12 Gene

Relevant External Links for FBXL12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBXL12

No disorders were found for FBXL12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL12 Gene

Publications for FBXL12 Gene

  1. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. (PMID: 23707388) Mallampalli R.K. … Agassandian M. (Cell. Signal. 2013) 3 4 67
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. (PMID: 24035498) Tan M.K. … Harper J.W. (Mol. Cell 2013) 3
  5. An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation. (PMID: 23324393) Postow L. … Funabiki H. (Cell Cycle 2013) 3

Products for FBXL12 Gene

Sources for FBXL12 Gene

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