Aliases for FBXL12 Gene
Aliases for FBXL12 Gene
External Ids for FBXL12 Gene
- HGNC: 13611
- Entrez Gene: 54850
- Ensembl: ENSG00000127452
- OMIM: 609079
- UniProtKB: Q9NXK8
Previous GeneCards Identifiers for FBXL12 Gene
- GC19M010042
- GC19M010143
- GC19M009766
- GC19M009781
- GC19M009920
- GC19M009501
Summaries for FBXL12 Gene
-
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FBXL12 Gene
FBXL12 (F-Box And Leucine Rich Repeat Protein 12) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot for FBXL12 Gene
-
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL12 Gene
Genomics for FBXL12 Gene
Regulatory Elements for FBXL12 Gene
Regulatory Element Products
Genomic Location for FBXL12 Gene
- Chromosome:
- 19
- Start:
- 9,810,267 bp from pter
- End:
- 9,827,816 bp from pter
- Size:
- 17,550 bases
- Orientation:
- Minus strand
Genomic View for FBXL12 Gene
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FBXL12 Gene
Proteins for FBXL12 Gene
-
Protein details for FBXL12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NXK8-FXL12_HUMAN
- Recommended name:
- F-box/LRR-repeat protein 12
- Protein Accession:
- Q9NXK8
- B3KSJ8
- Q9H5K4
Protein attributes for FBXL12 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 37026 Da
- Quaternary structure:
-
- Interacts with SKP1 and CUL1.
Protein Expression for FBXL12 Gene
Post-translational modifications for FBXL12 Gene
Other Protein References for FBXL12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FBXL12
- Invitrogen Antibodies for FBXL12
- antibodies-online Antibodies for FBXL12: See all 40
- GeneTex FBXL12 antibody for FBXL12
Protein Products
-
OriGene Purified Proteins for FBXL12
- Search Origene for MassSpec and Protein Over-expression Lysates for FBXL12
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- antibodies-online Proteins for FBXL12: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for FBXL12
Assay Products
- antibodies-online Kits for FBXL12: See all 21
No data available for DME Specific Peptides for FBXL12 Gene
Domains & Families for FBXL12 Gene
Gene Families for FBXL12 Gene
Protein Domains for FBXL12 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FBXL12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FBXL12 Gene
Function for FBXL12 Gene
Molecular function for FBXL12 Gene
- UniProtKB/Swiss-Prot Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18660753 |
Phenotypes for FBXL12 Gene
- MGI mutant phenotypes for FBXL12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FBXL12:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Upregulation of Wnt pathway
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Models for FBXL12 Gene
- MGI Knock Outs for FBXL12:
-
- Fbxl12 tm1Kei
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL12 gene
- Search ViGene Biosciences for FBXL12
CRISPR Products
-
OriGene CRISPR knockouts for FBXL12
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL12
- GenScript: Design CRISPR guide RNA sequences for FBXL12
miRNA Products
- Search ViGene Biosciences for FBXL12
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL12
- Browse OriGene Inhibitory RNA Products For FBXL12
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL12 gene
Clone Products
-
OriGene ORF clones in human for FBXL12
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for FBXL12
-
ViGene Biosciences adenoviral particle packaged cDNA for FBXL12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FBXL12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL12 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FBXL12 Gene
Localization for FBXL12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL12 Gene
Pathways & Interactions for FBXL12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for FBXL12 Gene
4 Reactome pathways for FBXL12 Gene
UniProtKB/Swiss-Prot Q9NXK8-FXL12_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for FBXL12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for FBXL12 Gene
Transcripts for FBXL12 Gene
mRNA/cDNA for FBXL12 Gene
- (10) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (174) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FBXL12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FBXL12
-
Santa Cruz Biotechnology (SCBT) CRISPR for FBXL12
- GenScript: Design CRISPR guide RNA sequences for FBXL12
miRNA Products
- Search ViGene Biosciences for FBXL12
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FBXL12
- Browse OriGene Inhibitory RNA Products For FBXL12
-
ViGene Biosciences ready-to-package AAV shRNAs for FBXL12 gene
Clone Products
-
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Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i | · | 6j |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP11: |
Expression for FBXL12 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBXL12 Gene
NURSA nuclear receptor signaling pathways regulating expression of FBXL12 Gene:
FBXL12SOURCE GeneReport for Unigene cluster for FBXL12 Gene:
Hs.12439Evidence on tissue expression from TISSUES for FBXL12 Gene
- Intestine(4.2)
- Nervous system(2.7)
Primer Products
-
OriGene qPCR primer pairs for FBXL12
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBXL12 Gene
Orthologs for FBXL12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FBXL12 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FBXL12 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FBXL12 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Fbxl12 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fbxl12 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FBXL12 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100859027 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FBXL12 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fbxl12 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8417 35 |
|
OneToOne |
- Species where no ortholog for FBXL12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FBXL12 Gene
Pseudogenes.org Pseudogenes for FBXL12 Gene
No data available for Paralogs for FBXL12 Gene
Variants for FBXL12 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000378821 | -- | 9,814,530(+) | ATTAA(A/T)TTAAA | intron-variant, upstream-variant-2KB | |
| rs1000424959 | -- | 9,813,823(+) | TAGTA(C/G)AGACA | intron-variant | |
| rs1000771870 | -- | 9,816,636(+) | AGTCA(C/T)TCAAC | intron-variant | |
| rs1000828791 | -- | 9,820,244(+) | GCAGA(A/G)CAAGG | intron-variant, upstream-variant-2KB | |
| rs1000854056 | -- | 9,814,889(+) | TCAAG(C/T)TGAGA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2669314 | CNV | deletion | 23128226 |
| esv3643642 | CNV | loss | 21293372 |
| nsv520683 | CNV | loss | 19592680 |
Relevant External Links for FBXL12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FBXL12
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL12 Gene
Disorders for FBXL12 Gene
Relevant External Links for FBXL12
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- FBXL12
No disorders were found for FBXL12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBXL12 Gene
Publications for FBXL12 Gene
- Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. (PMID: 23707388) Mallampalli R.K. … Agassandian M. (Cell. Signal. 2013) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3 64
- A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S. … Beisel C. (Cell Rep 2016) 3 64
Products for FBXL12 Gene
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- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FBXL12
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- OriGene qPCR primer pairs for FBXL12
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- Novus Biologicals Antibodies for FBXL12
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for FBXL12: See all 40
- antibodies-online Kits for FBXL12: See all 21
- antibodies-online Proteins for FBXL12: See all 7
- Search antibodies-online for peptides
- GeneTex FBXL12 antibody for FBXL12
- Search GeneTex for Proteins for FBXL12
- ViGene Biosciences adenoviral particle packaged cDNA for FBXL12 gene
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- Horizon Cell Lines for FBXL12
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- VectorBuilder custom plasmid, inducible vectors for FBXL12
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FBXL12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




