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Aliases for FBXL12 Gene

Aliases for FBXL12 Gene

  • F-Box And Leucine-Rich Repeat Protein 12 2 3 4
  • Fbl12 3 4 6
  • F-Box Protein FBL12 3 4
  • F-Box/LRR-Repeat Protein 12 3

External Ids for FBXL12 Gene

Previous GeneCards Identifiers for FBXL12 Gene

  • GC19M010042
  • GC19M010143
  • GC19M009766
  • GC19M009781
  • GC19M009920
  • GC19M009501

Summaries for FBXL12 Gene

Entrez Gene Summary for FBXL12 Gene

  • Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBXL12 Gene

FBXL12 (F-Box And Leucine-Rich Repeat Protein 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FBXL12 Gene

  • Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBXL12 Gene

Genomics for FBXL12 Gene

Regulatory Elements for FBXL12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBXL12 Gene

9,810,267 bp from pter
9,827,816 bp from pter
17,550 bases
Minus strand

Genomic View for FBXL12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBXL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBXL12 Gene

Proteins for FBXL12 Gene

  • Protein details for FBXL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    F-box/LRR-repeat protein 12
    Protein Accession:
    Secondary Accessions:
    • B3KSJ8
    • Q9H5K4

    Protein attributes for FBXL12 Gene

    326 amino acids
    Molecular mass:
    37026 Da
    Quaternary structure:
    • Interacts with SKP1 and CUL1.

    Alternative splice isoforms for FBXL12 Gene


neXtProt entry for FBXL12 Gene

Proteomics data for FBXL12 Gene at MOPED

Post-translational modifications for FBXL12 Gene

  • Ubiquitination at Lys305
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBXL12 Gene

Domains for FBXL12 Gene

Gene Families for FBXL12 Gene

  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for FBXL12 Gene


Suggested Antigen Peptide Sequences for FBXL12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NXK8
  • Contains 1 F-box domain.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with FBXL12: view

Function for FBXL12 Gene

Molecular function for FBXL12 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.

Gene Ontology (GO) - Molecular Function for FBXL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18660753
genes like me logo Genes that share ontologies with FBXL12: view
genes like me logo Genes that share phenotypes with FBXL12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBXL12 Gene

Localization for FBXL12 Gene

Subcellular locations from

Jensen Localization Image for FBXL12 Gene COMPARTMENTS Subcellular localization image for FBXL12 gene
Compartment Confidence
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBXL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FBXL12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBXL12 Gene

Pathways for FBXL12 Gene

SuperPathways for FBXL12 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NXK8-FXL12_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for FBXL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with FBXL12: view

No data available for Pathways by source for FBXL12 Gene

Transcripts for FBXL12 Gene

Unigene Clusters for FBXL12 Gene

F-box and leucine-rich repeat protein 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBXL12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FBXL12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBXL12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i · 6j
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP10: - - - - -

Relevant External Links for FBXL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBXL12 Gene

mRNA expression in normal human tissues for FBXL12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBXL12 Gene

SOURCE GeneReport for Unigene cluster for FBXL12 Gene Hs.12439

genes like me logo Genes that share expressions with FBXL12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBXL12 Gene

Orthologs for FBXL12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBXL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBXL12 35
  • 99.49 (n)
  • 100 (a)
FBXL12 36
  • 100 (a)
(Bos Taurus)
Mammalia FBXL12 35
  • 90.29 (n)
  • 94.48 (a)
FBXL12 36
  • 94 (a)
(Canis familiaris)
Mammalia FBXL12 35
  • 90.59 (n)
  • 96.01 (a)
FBXL12 36
  • 96 (a)
(Mus musculus)
Mammalia Fbxl12 35
  • 86.61 (n)
  • 93.25 (a)
Fbxl12 16
Fbxl12 36
  • 93 (a)
(Monodelphis domestica)
Mammalia FBXL12 36
  • 45 (a)
(Rattus norvegicus)
Mammalia Fbxl12 35
  • 86.08 (n)
  • 92.67 (a)
(Gallus gallus)
Aves LOC100859027 35
  • 53.08 (n)
  • 40.41 (a)
(Anolis carolinensis)
Reptilia FBXL12 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbxl12 35
  • 46.71 (n)
  • 39.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8417 36
  • 23 (a)
Species with no ortholog for FBXL12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FBXL12 Gene

Gene Tree for FBXL12 (if available)
Gene Tree for FBXL12 (if available)

Paralogs for FBXL12 Gene Pseudogenes for FBXL12 Gene

genes like me logo Genes that share paralogs with FBXL12: view

No data available for Paralogs for FBXL12 Gene

Variants for FBXL12 Gene

Sequence variations from dbSNP and Humsavar for FBXL12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs875338 -- 9,810,429(-) TACAC(A/G)CACGC utr-variant-3-prime
rs2081066 -- 9,817,368(-) ATTTG(A/G)CAAGG intron-variant
rs4044950 -- 9,812,778(+) AAAAA(-/AAA)CAACA intron-variant
rs9789296 -- 9,813,006(+) aagca(A/G)aggct intron-variant
rs9973297 -- 9,819,363(+) TCAGG(A/G)GCGGA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FBXL12 Gene

Variant ID Type Subtype PubMed ID
nsv520683 CNV Loss 19592680
esv2669314 CNV Deletion 23128226

Relevant External Links for FBXL12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBXL12 Gene

Disorders for FBXL12 Gene

No disorders were found for FBXL12 Gene.

No data available for UniProtKB/Swiss-Prot for FBXL12 Gene

Publications for FBXL12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. (PMID: 23707388) Mallampalli R.K. … Agassandian M. (Cell. Signal. 2013) 3 4
  4. A family of mammalian F-box proteins. (PMID: 10531037) Winston J.T. … Harper J.W. (Curr. Biol. 1999) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FBXL12 Gene

Sources for FBXL12 Gene

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