FBRSL1 Gene
protein-coding GIFtS: 39
GCID: GC12P133067
|
|
fibrosin-like 1
| |
Aliases
for FBRSL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibrosin-Like 11 2 | | HBV XAg-Transactivated Protein 92 3 | | KIAA15451 3 | | Fibrosin-1-Like Protein2 | | AUTS2-Like Protein2 3 | | AUTS2L3 | | HBV X-Transactivated Gene 9 Protein2 3 | | XTP93 |
Export aliases for FBRSL1 gene to outside databasesPrevious GC identifers: GC12P131578 GC12P129866 |
Summaries
for FBRSL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FBRSL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_024477.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBRSL1 gene promoter:
COUP-TF1 RFX1 p300 GCNF HNF-4alpha2 HNF-4alpha1 RORalpha1 COUP-TF GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBRSL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBRSL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33FBRSL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P133067: view genomic region
(about GC identifiers)
Start:
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133,066,137 bp from pter |
End:
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133,161,774 bp from pter |
Size:
|
95,638 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr6-,ALT_REF_LOCI_2 29,850,383-29,850,893 |
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Proteins
for FBRSL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBSL_HUMAN, Q9HCM7 (See
protein sequence)Recommended Name: Fibrosin-1-like protein Size: 1045 amino acids; 110907 Da
Sequence caution: Sequence=EAW54843.1; Type=Erroneous gene model prediction;
Secondary accessions: Q86XQ1Explore the universe of human proteins at neXtProt for FBRSL1: NX_Q9HCM7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCM7
FBRSL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001136113.1
ENSEMBL proteins: ENSP00000396160 ENSP00000261673
Human Recombinant Protein Products:
FBRSL1 Antibody Products:
Assay Products for FBRSL1: |
Protein
Domains /
Families
for FBRSL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBRSL1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HCM7ProtoNet protein and cluster: Q9HCM7 UniProtKB/Swiss-Prot: FBSL_HUMAN, Q9HCM7Similarity: Belongs to the AUTS2 family |
Function
for FBRSL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBRSL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBRSL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBRSL1 (NM_001142641) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBRSL1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FBRSL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBRSL1 |
|
Pathways & Interactions
for FBRSL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBRSL1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for FBRSL1 (ENSP000003961604) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FBRSL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBRSL1
Search CenterWatch for drugs/clinical trials and news about FBRSL1 / FBSL
|
Transcripts
for FBRSL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBRSL1 gene: NM_001142641.1 Unigene Clusters for FBRSL1: Fibrosin-like 1 Hs.411138 [show with all ESTs], Hs.656668 [show with all ESTs]Unigene Representative Sequences: NM_001142641, BC01328410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434748(uc001ukf.3) ENST00000542061 ENST00000541831 ENST00000539264
ENST00000543360 ENST00000543453 ENST00000536075 ENST00000542306 ENST00000537804
ENST00000261673
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBRSL1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBRSL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBRSL1 (NM_001142641) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBRSL1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FBRSL1 |
Additional cDNA sequence: BC013284.2 12 DOTS entries: DT.456128 DT.40189617 DT.100755339 DT.91669962 DT.102827457 DT.121175784 DT.439423 DT.121175758 DT.442812 DT.75101599 DT.91672715 DT.121175799 24/162 AceView cDNA sequences (see all 162): AI766674 CF890849 BM823924 BM757167 BM663609 AW291805 F13464 BM684376 AB046765 AF490258 AW961012 BC013284 AA385753 BU738867 AI475804 F34137 AI017469 AW418684 AI818967 BQ440423 AI818948 BQ086164 AI825140 CR596926
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBRSL1 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBRSL1
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Expression
for FBRSL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBRSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGACCCCAC
About this image
See FBRSL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBRSL1
SOURCE GeneReport for Unigene clusters: Hs.411138 Hs.656668
SABiosciences Custom PCR Arrays for FBRSL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBRSL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBRSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBRSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBRSL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBRSL1 |
Orthologs
for FBRSL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBRSL1 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for FBRSL1 (if available)
TreeFam Gene Tree for FBRSL1 (if available) |
Paralogs
for FBRSL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBRSL1 gene
- FBRS2 AUTS22
FBRSL1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FBRSL1
PGOHUM00000238170
|
Genomic Variants
for FBRSL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBRSL1 (133066137 - 133161774 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for FBRSL1
2 CNVs: 4404 71660
5 Indels: 24953 24952 45013 45014 11657 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBRSL1 |
|
Disorders
/ Diseases
for FBRSL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBRSL1 for disorders About GeneDecksing
2  diseases for FBRSL1: About MalaCardssystemic lupus erythematosus lupus erythematosus
Export disorders for FBRSL1 gene to outside databases
|
Publications
for FBRSL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBRSL1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FBRSL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
- PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)2 Nakajima D.... Nagase T. (2002)
|
External Searches for FBRSL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBRSL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBRSL1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FBRSL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBRSL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBRSL1 gene:
Search GeneIP for patents involving FBRSL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBRSL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBRSL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBRSL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBRSL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBRSL1 | | OriGene 3'-UTR Clone for FBRSL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBRSL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBRSL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FBRSL1 | | OriGene Custom Protein Services for FBRSL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBRSL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBRSL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBRSL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBRSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBRSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBRSL1 |
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| | | | Search Tocris compounds for FBRSL1 |
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 | | | FBRSL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBRSL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for FBRSL1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FBRSL1 |
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