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Aliases for FBRSL1 Gene

Aliases for FBRSL1 Gene

  • Fibrosin Like 1 2 3 5
  • HBV X-Transactivated Gene 9 Protein 4
  • HBV XAg-Transactivated Protein 9 4
  • AUTS2-Like Protein 4
  • Fibrosin-Like 1 2
  • KIAA1545 4
  • AUTS2L 4
  • XTP9 4

External Ids for FBRSL1 Gene

Previous GeneCards Identifiers for FBRSL1 Gene

  • GC12P131578
  • GC12P133067
  • GC12P129866

Summaries for FBRSL1 Gene

GeneCards Summary for FBRSL1 Gene

FBRSL1 (Fibrosin Like 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is AUTS2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBRSL1 Gene

Genomics for FBRSL1 Gene

Regulatory Elements for FBRSL1 Gene

Enhancers for FBRSL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G132487 1.6 FANTOM5 ENCODE dbSUPER 34.4 +2.5 2528 9.3 FOXA2 ARID4B SIN3A ZBTB7B ZNF143 ZNF263 ZHX2 REST ZNF579 SMARCA4 FBRSL1 ZNF140 ENSG00000256875 ZNF10 EP400 EP400NL ZNF891 ZNF84 GOLGA3 DDX51
GH12G132502 2 FANTOM5 Ensembl ENCODE dbSUPER 24.5 +17.5 17514 8.5 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZNF140 ENSG00000256875 FBRSL1 ZNF26 ZNF10 EP400 ZNF84 GOLGA3 DDX51 ZNF605
GH12G132443 2 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -44.2 -44196 3.6 PKNOX1 CREB3L1 ARNT SIN3A ZBTB7B ZNF766 FOS ZNF263 ZHX2 JUNB FBRSL1 EP400 ENSG00000256783 ENSG00000256875 DDX51 POLE PIR39758 PIR42732
GH12G132473 1.3 FANTOM5 Ensembl ENCODE 29.6 -13.8 -13837 3.9 ZSCAN5A RFX1 BHLHE40 NR3C1 GABPA RAD51 NR2C1 CREB1 ZBTB33 KDM1A FBRSL1 ENSG00000256875 GOLGA3 EP400NL MUC8 GC12M132488
GH12G132470 1.6 Ensembl ENCODE dbSUPER 21.1 -17.6 -17627 2.6 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B DMAP1 SLC30A9 ZNF766 CBX5 ENSG00000256875 FBRSL1 GC12P132472
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBRSL1 on UCSC Golden Path with GeneCards custom track

Promoters for FBRSL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059512 649 2001 HDAC1 RB1 SIN3A ZBTB40 ZNF48 EGR1 CREM ZNF263 HCFC1 SMAD5

Genomic Location for FBRSL1 Gene

Chromosome:
12
Start:
132,489,551 bp from pter
End:
132,585,188 bp from pter
Size:
95,638 bases
Orientation:
Plus strand

Genomic View for FBRSL1 Gene

Genes around FBRSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBRSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBRSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBRSL1 Gene

Proteins for FBRSL1 Gene

  • Protein details for FBRSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCM7-FBSL_HUMAN
    Recommended name:
    Fibrosin-1-like protein
    Protein Accession:
    Q9HCM7
    Secondary Accessions:
    • Q86XQ1

    Protein attributes for FBRSL1 Gene

    Size:
    1045 amino acids
    Molecular mass:
    110907 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW54843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for FBRSL1 Gene

Post-translational modifications for FBRSL1 Gene

  • Ubiquitination at isoforms=484
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FBRSL1 Gene

Domains & Families for FBRSL1 Gene

Protein Domains for FBRSL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBRSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCM7

UniProtKB/Swiss-Prot:

FBSL_HUMAN :
  • Belongs to the AUTS2 family.
Family:
  • Belongs to the AUTS2 family.
genes like me logo Genes that share domains with FBRSL1: view

No data available for Gene Families for FBRSL1 Gene

Function for FBRSL1 Gene

Gene Ontology (GO) - Molecular Function for FBRSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with FBRSL1: view

Animal Model Products

miRNA for FBRSL1 Gene

miRTarBase miRNAs that target FBRSL1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBRSL1 Gene

Localization for FBRSL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBRSL1 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBRSL1 Gene

Pathways & Interactions for FBRSL1 Gene

SuperPathways for FBRSL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBRSL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBRSL1 Gene

Drugs & Compounds for FBRSL1 Gene

No Compound Related Data Available

Transcripts for FBRSL1 Gene

Unigene Clusters for FBRSL1 Gene

Fibrosin-like 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBRSL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for FBRSL1 Gene

GeneLoc Exon Structure for
FBRSL1
ECgene alternative splicing isoforms for
FBRSL1

Expression for FBRSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBRSL1 Gene

Protein differential expression in normal tissues from HIPED for FBRSL1 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBRSL1 Gene



Protein tissue co-expression partners for FBRSL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBRSL1 Gene:

FBRSL1

SOURCE GeneReport for Unigene cluster for FBRSL1 Gene:

Hs.411138

Evidence on tissue expression from TISSUES for FBRSL1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with FBRSL1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBRSL1 Gene

Orthologs for FBRSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBRSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBRSL1 34 35
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia FBRSL1 34 35
  • 82.06 (n)
mouse
(Mus musculus)
Mammalia Fbrsl1 34 16 35
  • 79.36 (n)
dog
(Canis familiaris)
Mammalia FBRSL1 34 35
  • 79.18 (n)
rat
(Rattus norvegicus)
Mammalia Fbrsl1 34
  • 79.1 (n)
oppossum
(Monodelphis domestica)
Mammalia FBRSL1 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBRSL1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves FBRSL1 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBRSL1 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbrsl1 35
  • 39 (a)
OneToOne
Species where no ortholog for FBRSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBRSL1 Gene

ENSEMBL:
Gene Tree for FBRSL1 (if available)
TreeFam:
Gene Tree for FBRSL1 (if available)

Paralogs for FBRSL1 Gene

Paralogs for FBRSL1 Gene

Pseudogenes.org Pseudogenes for FBRSL1 Gene

genes like me logo Genes that share paralogs with FBRSL1: view

Variants for FBRSL1 Gene

Sequence variations from dbSNP and Humsavar for FBRSL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000001599 -- 132,495,415(+) GAGTT(C/T)GCCAG intron-variant
rs1000017391 -- 132,558,163(+) GCACC(C/T)TGGGC intron-variant, utr-variant-3-prime
rs1000023145 -- 132,528,799(+) GTGTG(C/T)CGTGC intron-variant
rs1000039147 -- 132,564,708(+) GCCAG(A/G)ATGGT intron-variant
rs1000042865 -- 132,585,418(+) AAACC(C/T)CAGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FBRSL1 Gene

Variant ID Type Subtype PubMed ID
dgv220e201 CNV deletion 23290073
dgv3046n54 CNV loss 21841781
dgv3047n54 CNV gain 21841781
dgv3048n54 CNV gain 21841781
dgv3049n54 CNV gain 21841781
dgv3050n54 CNV loss 21841781
dgv3051n54 CNV loss 21841781
dgv3052n54 CNV loss 21841781
dgv316e214 CNV gain 21293372
dgv317e214 CNV loss 21293372
dgv948e59 CNV duplication 20981092
esv1040121 CNV deletion 17803354
esv1553523 CNV deletion 17803354
esv1562329 CNV insertion 17803354
esv1661784 CNV insertion 17803354
esv2040735 CNV deletion 18987734
esv2407620 CNV deletion 18987734
esv2663688 CNV deletion 23128226
esv2668583 CNV deletion 23128226
esv2678329 CNV deletion 23128226
esv2747002 CNV deletion 23290073
esv2747003 CNV deletion 23290073
esv2747004 CNV deletion 23290073
esv2747005 CNV deletion 23290073
esv2747006 CNV deletion 23290073
esv2747009 CNV deletion 23290073
esv2747010 CNV deletion 23290073
esv2747012 CNV deletion 23290073
esv2747013 CNV deletion 23290073
esv2747014 CNV deletion 23290073
esv2747015 CNV deletion 23290073
esv2747016 CNV deletion 23290073
esv2747017 CNV deletion 23290073
esv2747019 CNV deletion 23290073
esv29631 CNV loss 19812545
esv3550091 CNV deletion 23714750
esv3550092 CNV deletion 23714750
esv3631298 CNV loss 21293372
esv3631299 CNV gain 21293372
esv991918 CNV deletion 20482838
nsv1069726 CNV deletion 25765185
nsv1069727 CNV deletion 25765185
nsv1069728 CNV deletion 25765185
nsv1078756 CNV insertion 25765185
nsv1110216 CNV duplication 24896259
nsv1124669 CNV duplication 24896259
nsv1126336 CNV deletion 24896259
nsv1129166 CNV insertion 24896259
nsv1136164 CNV deletion 24896259
nsv1143582 CNV deletion 24896259
nsv1143583 CNV deletion 24896259
nsv1143721 CNV deletion 24896259
nsv1146094 CNV deletion 26484159
nsv1146872 CNV deletion 26484159
nsv455806 CNV loss 19166990
nsv455807 CNV loss 19166990
nsv455809 CNV loss 19166990
nsv470334 CNV loss 18288195
nsv509494 CNV insertion 20534489
nsv53631 CNV deletion 16902084
nsv561079 CNV gain+loss 21841781
nsv561084 CNV loss 21841781
nsv561085 CNV loss 21841781
nsv561091 CNV gain+loss 21841781
nsv561100 CNV loss 21841781
nsv561105 CNV loss 21841781
nsv826563 CNV gain 20364138
nsv826569 CNV gain 20364138
nsv952512 CNV deletion 24416366

Variation tolerance for FBRSL1 Gene

Gene Damage Index Score: 6.19; 75.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBRSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBRSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBRSL1 Gene

Disorders for FBRSL1 Gene

Relevant External Links for FBRSL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBRSL1

No disorders were found for FBRSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBRSL1 Gene

Publications for FBRSL1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3 64

Products for FBRSL1 Gene

Sources for FBRSL1 Gene

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