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Aliases for FBRS Gene

Aliases for FBRS Gene

  • Fibrosin 2 3 5
  • Fibrosin 1 2 3
  • FBS1 3 4
  • FBS 3 4
  • Probable Fibrosin-1 Long Transcript Protein 3
  • Fibrogenic Lymphokine 3

External Ids for FBRS Gene

Previous HGNC Symbols for FBRS Gene

  • FBS1

Previous GeneCards Identifiers for FBRS Gene

  • GC16P030579
  • GC16P028238

Summaries for FBRS Gene

Entrez Gene Summary for FBRS Gene

  • Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBRS Gene

FBRS (Fibrosin) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is AUTS2.

Gene Wiki entry for FBRS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBRS Gene

Genomics for FBRS Gene

Regulatory Elements for FBRS Gene

Enhancers for FBRS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FBRS on UCSC Golden Path with GeneCards custom track

Promoters for FBRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FBRS on UCSC Golden Path with GeneCards custom track

Genomic Location for FBRS Gene

Chromosome:
16
Start:
30,658,431 bp from pter
End:
30,670,814 bp from pter
Size:
12,384 bases
Orientation:
Plus strand

Genomic View for FBRS Gene

Genes around FBRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBRS Gene

Proteins for FBRS Gene

  • Protein details for FBRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAH7-FBRS_HUMAN
    Recommended name:
    Probable fibrosin-1
    Protein Accession:
    Q9HAH7
    Secondary Accessions:
    • B4DP86
    • Q96CI9
    • Q9H9X4

    Protein attributes for FBRS Gene

    Size:
    460 amino acids
    Molecular mass:
    48388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14094.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBRS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBRS Gene

Proteomics data for FBRS Gene at MOPED

Post-translational modifications for FBRS Gene

  • Ubiquitination at Lys 8 and Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for FBRS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBRS Gene

Domains & Families for FBRS Gene

Protein Domains for FBRS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FBRS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBRS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FBRS Gene

Function for FBRS Gene

genes like me logo Genes that share phenotypes with FBRS: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBRS Gene

Localization for FBRS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBRS Gene COMPARTMENTS Subcellular localization image for FBRS gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBRS Gene

Pathways & Interactions for FBRS Gene

SuperPathways for FBRS Gene

No Data Available

Interacting Proteins for FBRS Gene

Gene Ontology (GO) - Biological Process for FBRS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FBRS Gene

Drugs & Compounds for FBRS Gene

No Compound Related Data Available

Transcripts for FBRS Gene

Unigene Clusters for FBRS Gene

Fibrosin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBRS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - - - - - - - - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for FBRS Gene

GeneLoc Exon Structure for
FBRS
ECgene alternative splicing isoforms for
FBRS

Expression for FBRS Gene

mRNA expression in normal human tissues for FBRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBRS Gene

This gene is overexpressed in Placenta (46.8) and CD8 Tcells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBRS Gene



SOURCE GeneReport for Unigene cluster for FBRS Gene Hs.247186

genes like me logo Genes that share expression patterns with FBRS: view

Protein tissue co-expression partners for FBRS Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FBRS Gene

Orthologs for FBRS Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBRS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FBRS 35
  • 93.55 (n)
  • 97.85 (a)
FBRS 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBRS 35
  • 93.7 (n)
  • 98.04 (a)
FBRS 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbrs 35
  • 90.51 (n)
  • 95 (a)
Fbrs 16
Fbrs 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FBRS 35
  • 99.71 (n)
  • 100 (a)
FBRS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbrs 35
  • 90.65 (n)
  • 95 (a)
oppossum
(Monodelphis domestica)
Mammalia FBRS 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBRS 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBRS 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbrs 36
  • 22 (a)
OneToOne
Species with no ortholog for FBRS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBRS Gene

ENSEMBL:
Gene Tree for FBRS (if available)
TreeFam:
Gene Tree for FBRS (if available)

Paralogs for FBRS Gene

Paralogs for FBRS Gene

genes like me logo Genes that share paralogs with FBRS: view

Variants for FBRS Gene

Sequence variations from dbSNP and Humsavar for FBRS Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11846 -- 30,670,638(-) CGTGA(C/G)GCTGC utr-variant-3-prime
rs8062907 -- 30,657,325(+) gaacc(C/G/T)gagag upstream-variant-2KB
rs9925748 -- 30,668,203(+) CAGGC(A/G)GCTGG intron-variant
rs869074 -- 30,662,914(+) GGTGG(C/T)GGGGA intron-variant
rs869075 -- 30,663,061(+) TGCTG(G/T)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBRS Gene

Variant ID Type Subtype PubMed ID
nsv905727 CNV Loss 21882294
nsv469724 CNV Loss 16826518
nsv833188 CNV Loss 17160897
nsv905728 CNV Loss 21882294
nsv905729 CNV Loss 21882294
dgv2669n71 CNV Loss 21882294

Variation tolerance for FBRS Gene

Gene Damage Index Score: 3.07; 50.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FBRS Gene

Disorders for FBRS Gene

Relevant External Links for FBRS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBRS

No disorders were found for FBRS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBRS Gene

Publications for FBRS Gene

  1. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. (PMID: 9809749) Prakash S. … Robbins P.W. (DNA Cell Biol. 1998) 2 3 4 67
  2. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. (PMID: 7892239) Prakash S. … Wyler D.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for FBRS Gene

Sources for FBRS Gene

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