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Aliases for FBRS Gene

Aliases for FBRS Gene

  • Fibrosin 2 3
  • Fibrosin 1 2 3
  • Fbs1 3 4
  • FBS 3 4
  • Probable Fibrosin-1 Long Transcript Protein 3
  • Fibrogenic Lymphokine 3
  • Probable Fibrosin-1 3

External Ids for FBRS Gene

Previous Symbols for FBRS Gene

  • FBS1

Summaries for FBRS Gene

Entrez Gene Summary for FBRS Gene

  • Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBRS Gene

FBRS (Fibrosin) is a Protein Coding gene. An important paralog of this gene is AUTS2.

Gene Wiki entry for FBRS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBRS Gene

Genomics for FBRS Gene

Genomic Location for FBRS Gene

Start:
30,658,431 bp from pter
End:
30,670,814 bp from pter
Size:
12,384 bases
Orientation:
Plus strand

Genomic View for FBRS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBRS Gene

Regulatory Elements for FBRS Gene

Proteins for FBRS Gene

  • Protein details for FBRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAH7-FBRS_HUMAN
    Recommended name:
    Probable fibrosin-1
    Protein Accession:
    Q9HAH7
    Secondary Accessions:
    • B4DP86
    • Q96CI9
    • Q9H9X4

    Protein attributes for FBRS Gene

    Size:
    460 amino acids
    Molecular mass:
    48388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14094.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBRS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FBRS Gene

Proteomics data for FBRS Gene at MOPED

Post-translational modifications for FBRS Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8 and Lys68

Other Protein References for FBRS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FBRS Gene

Domains for FBRS Gene

Protein Domains for FBRS Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with FBRS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FBRS Gene

Function for FBRS Gene

Gene Ontology (GO) - Molecular Function for FBRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity --
genes like me logo Genes that share ontologies with FBRS: view

Phenotypes for FBRS Gene

GenomeRNAi human phenotypes for FBRS:
genes like me logo Genes that share phenotypes with FBRS: view

miRNA for FBRS Gene

miRTarBase miRNAs that target FBRS

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBRS Gene

Localization for FBRS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBRS Gene COMPARTMENTS Subcellular localization image for FBRS gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FBRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space --
genes like me logo Genes that share ontologies with FBRS: view

Pathways for FBRS Gene

SuperPathways for FBRS Gene

No Data Available

Interacting Proteins for FBRS Gene

Gene Ontology (GO) - Biological Process for FBRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048146 positive regulation of fibroblast proliferation --
genes like me logo Genes that share ontologies with FBRS: view

No data available for Pathways by source for FBRS Gene

Transcripts for FBRS Gene

Unigene Clusters for FBRS Gene

Fibrosin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBRS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - - - - - - - - -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for FBRS Gene

GeneLoc Exon Structure for
FBRS
ECgene alternative splicing isoforms for
FBRS

Expression for FBRS Gene

mRNA expression in normal human tissues for FBRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBRS Gene

SOURCE GeneReport for Unigene cluster for FBRS Gene Hs.247186

genes like me logo Genes that share expressions with FBRS: view

Orthologs for FBRS Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBRS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBRS 36
  • 99.71 (n)
  • 100 (a)
FBRS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBRS 36
  • 93.55 (n)
  • 97.85 (a)
FBRS 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBRS 36
  • 93.7 (n)
  • 98.04 (a)
FBRS 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbrs 36
  • 90.51 (n)
  • 95 (a)
Fbrs 16
Fbrs 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FBRS 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FBRS 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fbrs 36
  • 90.65 (n)
  • 95 (a)
lizard
(Anolis carolinensis)
Reptilia FBRS 37
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fbrs 37
  • 22 (a)
OneToOne
Species with no ortholog for FBRS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBRS Gene

ENSEMBL:
Gene Tree for FBRS (if available)
TreeFam:
Gene Tree for FBRS (if available)

Paralogs for FBRS Gene

Paralogs for FBRS Gene

genes like me logo Genes that share paralogs with FBRS: view

Variants for FBRS Gene

Sequence variations from dbSNP and Humsavar for FBRS Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11846 -- 30,670,638(-) CGTGA(C/G)GCTGC utr-variant-3-prime
rs869074 -- 30,662,914(+) GGTGG(C/T)GGGGA upstream-variant-2KB
rs869075 -- 30,663,061(+) TGCTG(G/T)TTCCC upstream-variant-2KB
rs893924 -- 30,663,725(+) GTCAC(C/T)GTCAT upstream-variant-2KB
rs893925 -- 30,663,833(+) ggtct(C/T)ctgac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBRS Gene

Variant ID Type Subtype PubMed ID
nsv905727 CNV Loss 21882294
nsv469724 CNV Loss 16826518
nsv833188 CNV Loss 17160897
nsv905728 CNV Loss 21882294
nsv905729 CNV Loss 21882294
dgv2669n71 CNV Loss 21882294

Relevant External Links for FBRS Gene

HapMap Linkage Disequilibrium report
FBRS

Disorders for FBRS Gene

(1) University of Copenhagen DISEASES for FBRS Gene

genes like me logo Genes that share disorders with FBRS: view

No data available for UniProtKB/Swiss-Prot for FBRS Gene

Publications for FBRS Gene

  1. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. (PMID: 9809749) Prakash S. … Robbins P.W. (DNA Cell Biol. 1998) 2 3 4
  2. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. (PMID: 7892239) Prakash S. … Wyler D.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for FBRS Gene

Sources for FBRS Gene

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