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Aliases for FBRS Gene

Aliases for FBRS Gene

  • Fibrosin 2 3 5
  • Fibrosin 1 2 3
  • FBS1 3 4
  • FBS 3 4
  • Probable Fibrosin-1 Long Transcript Protein 3
  • Fibrogenic Lymphokine 3
  • Probable Fibrosin-1 3

External Ids for FBRS Gene

Previous HGNC Symbols for FBRS Gene

  • FBS1

Previous GeneCards Identifiers for FBRS Gene

  • GC16P030579
  • GC16P028238

Summaries for FBRS Gene

Entrez Gene Summary for FBRS Gene

  • Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FBRS Gene

FBRS (Fibrosin) is a Protein Coding gene. GO annotations related to this gene include growth factor activity. An important paralog of this gene is AUTS2.

Gene Wiki entry for FBRS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBRS Gene

Genomics for FBRS Gene

Regulatory Elements for FBRS Gene

Enhancers for FBRS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030633 1.8 FANTOM5 Ensembl ENCODE 11.8 -23.7 -23731 2.6 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 CCDC189 ZNF764 ZNF688 SRCAP ZNF785 ENSG00000239791 FBRS DCTPP1 ZNF629 RNU6-1043P
GH16G031125 2 FANTOM5 Ensembl ENCODE dbSUPER 7.7 +472.7 472708 10.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 KAT8 ITGAX ZNF764 BCL7C ITGAM ZNF646 ZNF668 ENSG00000260267 ENSG00000260304 NPIPB13
GH16G030598 1.4 Ensembl ENCODE 10.8 -60.1 -60130 0.6 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF302 ZNF143 ENSG00000260267 ZNF764 ENSG00000260304 ENSG00000235560 PRR14 NPIPB13 ENSG00000239791 BCL7C ENSG00000261474 DCTPP1
GH16G030628 1.2 Ensembl ENCODE 11.7 -29.4 -29414 1.0 ARNT WRNIP1 ARID4B ZNF2 YY1 SLC30A9 ZNF766 ZNF143 REST PPARG CCDC189 PRR14 FBRS ZNF785 ENSG00000239791 ZNF688 SEPHS2 SRCAP SNORA30 PIR47019
GH16G030602 0.9 ENCODE 11.1 -55.0 -54991 2.4 AGO1 ARID4B ZNF2 YY1 TCF12 GLIS2 FOS ZNF263 YY2 NFYC ZNF764 PRR14 ENSG00000260267 ENSG00000260304 ZNF688 ENSG00000239791 BCL7C SEPHS2 FBRS TBC1D10B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBRS on UCSC Golden Path with GeneCards custom track

Promoters for FBRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085232 769 2801 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for FBRS Gene

30,658,431 bp from pter
30,670,814 bp from pter
12,384 bases
Plus strand

Genomic View for FBRS Gene

Genes around FBRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBRS Gene

Proteins for FBRS Gene

  • Protein details for FBRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable fibrosin-1
    Protein Accession:
    Secondary Accessions:
    • B4DP86
    • Q96CI9
    • Q9H9X4

    Protein attributes for FBRS Gene

    460 amino acids
    Molecular mass:
    48388 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14094.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FBRS Gene


neXtProt entry for FBRS Gene

Post-translational modifications for FBRS Gene

  • Ubiquitination at Lys8 and isoforms=268
  • Modification sites at PhosphoSitePlus

Other Protein References for FBRS Gene

No data available for DME Specific Peptides for FBRS Gene

Domains & Families for FBRS Gene

Protein Domains for FBRS Gene


Suggested Antigen Peptide Sequences for FBRS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FBRS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FBRS Gene

Function for FBRS Gene

genes like me logo Genes that share phenotypes with FBRS: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FBRS Gene

Localization for FBRS Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBRS gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FBRS Gene

Pathways & Interactions for FBRS Gene

No Data Available

Gene Ontology (GO) - Biological Process for FBRS Gene


No data available for Pathways by source and SIGNOR curated interactions for FBRS Gene

Drugs & Compounds for FBRS Gene

No Compound Related Data Available

Transcripts for FBRS Gene

Unigene Clusters for FBRS Gene

Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBRS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - - - - - - - - -
SP3: -

Relevant External Links for FBRS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBRS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FBRS Gene

This gene is overexpressed in Placenta (46.8) and CD8 Tcells (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FBRS Gene

Protein tissue co-expression partners for FBRS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FBRS Gene:


SOURCE GeneReport for Unigene cluster for FBRS Gene:

genes like me logo Genes that share expression patterns with FBRS: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FBRS Gene

Orthologs for FBRS Gene

This gene was present in the common ancestor of chordates.

Orthologs for FBRS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBRS 34 35
  • 99.71 (n)
(Canis familiaris)
Mammalia FBRS 34 35
  • 93.7 (n)
(Bos Taurus)
Mammalia FBRS 34 35
  • 93.55 (n)
(Rattus norvegicus)
Mammalia Fbrs 34
  • 90.65 (n)
(Mus musculus)
Mammalia Fbrs 34 16 35
  • 90.51 (n)
(Monodelphis domestica)
Mammalia FBRS 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia FBRS 35
  • 86 (a)
(Anolis carolinensis)
Reptilia FBRS 35
  • 40 (a)
(Danio rerio)
Actinopterygii fbrs 35
  • 22 (a)
Species where no ortholog for FBRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FBRS Gene

Gene Tree for FBRS (if available)
Gene Tree for FBRS (if available)

Paralogs for FBRS Gene

Paralogs for FBRS Gene

genes like me logo Genes that share paralogs with FBRS: view

Variants for FBRS Gene

Sequence variations from dbSNP and Humsavar for FBRS Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000024822 -- 30,661,844(+) CATGT(A/G)AGTAA intron-variant
rs1000037008 -- 30,667,556(+) ACGCT(A/G)CAGCC reference, missense
rs1000119615 -- 30,657,698(+) TGGCT(A/G)GGAGA upstream-variant-2KB
rs1000269889 -- 30,657,300(+) GAGGC(C/T)GAGCC upstream-variant-2KB
rs1000278530 -- 30,657,893(+) CTGCC(G/T)GTTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FBRS Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897

Variation tolerance for FBRS Gene

Gene Damage Index Score: 3.07; 50.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBRS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBRS Gene

Disorders for FBRS Gene

Relevant External Links for FBRS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FBRS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FBRS Gene

Publications for FBRS Gene

  1. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. (PMID: 9809749) Prakash S. … Robbins P.W. (DNA Cell Biol. 1998) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. (PMID: 7892239) Prakash S. … Wyler D.J. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64

Products for FBRS Gene

Sources for FBRS Gene

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