FBRS Gene
protein-coding GIFtS: 45
GCID: GC16P030670
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fibrosin(Previous name: fibrosin 1 )
(Previous symbol: FBS1)
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Aliases
for FBRS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fibrosin1 | | FLJ116181 | | FBS1 2 3 | | Fibrogenic Lymphokine2 | | FBS11 2 3 | | Probable Fibrosin-12 | | Fibrosin 11 2 | | Probable Fibrosin-1 Long Transcript Protein2 |
Export aliases for FBRS gene to outside databasesPrevious GC identifers: GC16P030579 GC16P028238 |
Summaries
for FBRS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FBRS:
Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins,1998 (PubMed 9809749)).(supplied by OMIM, Mar 2008)
Gene Wiki entry for FBRS
|
Genomic Views
for FBRS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FBRS gene promoter:
E2F-3a E2F-4 E2F-5 Pax-5 E2F-2 PPAR-alpha E2F E2F-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FBRS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBRS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2FBRS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P030670: view genomic region
(about GC identifiers)
Start:
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30,669,752 bp from pter |
End:
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30,682,131 bp from pter |
Size:
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12,380 bases |
Orientation:
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plus strand |
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Proteins
for FBRS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FBRS_HUMAN, Q9HAH7 (See
protein sequence)Recommended Name: Probable fibrosin-1 Size: 460 amino acids; 48388 Da
Caution: Prakash et al. cloned a cDNA corresponding to the 3'UTR of the last exon of the gene (PubMed:9809749). Theyhave shown that a synthetic peptide derived from this sequence could stimulate fibroblasts growth in vitro, and thatthis protein could be a fibrogenic lymphokine, that could stimulate several biological activities related to scarring.It would be expressed in placenta, skeletal muscle, pancreas, thymus, testis, and leukocytes. However, it was notconfirmed by in vivo data
Sequence caution: Sequence=BAB13872.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB14094.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DP86 Q96CI9 Q9H9X4Alternative splicing: 2 isoforms: Q9HAH7-2 Q9HAH7-1 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FBRS: NX_Q9HAH7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HAH7
FBRS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001098549.1
ENSEMBL proteins: ENSP00000348489 ENSP00000456204 ENSP00000287468 ENSP00000378511 ENSP00000454920
Human Recombinant Protein Products:
FBRS Antibody Products:
Assay Products for FBRS: |
Protein
Domains /
Families
for FBRS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FBRS for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HAH7ProtoNet protein and cluster: Q9HAH7 |
Function
for FBRS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBRS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBRS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FBRS (NM_001142641) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBRS | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FBRS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBRS |
1 GenomeRNAi human phenotype for FBRS:
|
Pathways & Interactions
for FBRS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FBRS
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for FBRS (ENSP000002874684) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FBRS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FBRS
Search CenterWatch for drugs/clinical trials and news about FBRS
|
Transcripts
for FBRS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FBRS gene (2 alternative transcripts): NM_022452.1 NM_001105079.1 Unigene Cluster for FBRS: Fibrosin Hs.247186 [show with all ESTs]Unigene Representative Sequence: AK09632211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356166 ENST00000498588 ENST00000543786 ENST00000484152 ENST00000482749
ENST00000468966 ENST00000570170 ENST00000494101 ENST00000287468(uc002dzd.4)
ENST00000395073 ENST00000568722(uc002dzc.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBRS (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBRS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FBRS (NM_001142641) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FBRS | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FBRS |
Additional cDNA sequence: AK021680.1 AK022551.1 AK093045.1 AK096322.1 AK298229.1 HQ013238.1 8 DOTS entries: DT.447958 DT.100031108 DT.100785441 DT.70100132 DT.95297532 DT.95173463 DT.95272123 DT.97824578 24/227 AceView cDNA sequences (see all 227): CD368381 AW248480 AA324927 AW182673 BU192997 BI062201 BU947732 BQ023215 BM678377 BG251408 BG685089 AK096322 AI741283 BU145914 BQ641673 AU280124 BM676664 AW189458 BQ675714 CF125915 BQ673021 BQ687442 BM970867 CD518797
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FBRS (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FBRS
|
Expression
for FBRS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FBRS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGCGAAT
About this image
See FBRS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FBRS
SOURCE GeneReport for Unigene cluster: Hs.247186
SABiosciences Custom PCR Arrays for FBRS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBRS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FBRS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBRS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBRS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBRS |
Orthologs
for FBRS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FBRS gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
FBRS6 |
-- |
52(a) |
1 ↔ 1 |
GL343516.1(160010-178042) |
zebrafish
(Danio rerio) |
Actinopterygii |
AL929039.26 |
-- |
27(a) |
1 ↔ 1 |
12(28607629-28632372) |
fruit fly
(Drosophila melanogaster) |
Insecta |
tay6 |
tay bridge |
7(a) |
1 → many |
X(15770716-15781319) |
ENSEMBL Gene Tree for FBRS (if available)
TreeFam Gene Tree for FBRS (if available) |
Paralogs
for FBRS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FBRS gene
- AUTS22 FBRSL12
FBRS for paralogs About GeneDecksing
|
Genomic Variants
for FBRS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FBRS (30669752 - 30682131 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FBRS
1 CNV: 2209 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBRS |
|
Disorders
/ Diseases
for FBRS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FBRS for disorders About GeneDecksing
OMIM gene information: 608601
OMIM disorders: --
3  diseases for FBRS: About MalaCardsschistosomiasis fibrosis alcoholism
1 disease from the University of Copenhagen DISEASES database for FBRS:Schistosomiasis Export disorders for FBRS gene to outside databases
|
Publications
for FBRS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FBRS gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FBRS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. (PubMed id 9809749)1, 2, 3 Prakash S. and Robbins P.W. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. (PubMed id 7892239)1, 3 Prakash S....Wyler D.J. (1995)
- PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts. (PubMed id 17083929)1 Prakash S....Robbins P.W. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
|
External Searches for FBRS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FBRS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FBRS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FBRS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FBRS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FBRS gene:
Search GeneIP for patents involving FBRS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FBRS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FBRS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBRS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FBRS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FBRS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FBRS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FBRS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FBRS | | OriGene Custom Protein Services for FBRS | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FBRS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FBRS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBRS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FBRS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FBRS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FBRS |
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| | | | Search Tocris compounds for FBRS |
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 | | | FBRS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBRS |
|  |  |  | | | | ThermoFisher Antibodies for FBRS |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FBRS |
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