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FBP2 Gene(Protein Coding)

Fructose-Bisphosphatase 2

GCID:
GC09M094558
GIFtS:
62
Genes Participants
UDN Logo

Aliases for FBP2 Gene

Aliases for FBP2 Gene

  • Fructose-Bisphosphatase 2 2 3 5
  • D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 2 3 4
  • Fructose-1,6-Bisphosphatase 2 2 3
  • Muscle FBPase 3 4
  • EC 3.1.3.11 4 61
  • FBPase 2 3 4
  • Fructose-1,6-Bisphosphatase Isozyme 2 3
  • Muscle Fructose-Bisphosphatase 3
  • Hexosediphosphatase 3
  • EC 3.1.3 61

External Ids for FBP2 Gene

Previous GeneCards Identifiers for FBP2 Gene

  • GC09M088147
  • GC09M089048
  • GC09M090621
  • GC09M092662
  • GC09M094400
  • GC09M096360
  • GC09M097321
  • GC09M066929

Summaries for FBP2 Gene

Entrez Gene Summary for FBP2 Gene

  • This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBP2 Gene

FBP2 (Fructose-Bisphosphatase 2) is a Protein Coding gene. Diseases associated with FBP2 include Fructose-1,6-Bisphosphatase Deficiency. Among its related pathways are Glucose metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include phosphoric ester hydrolase activity and fructose 1,6-bisphosphate 1-phosphatase activity. An important paralog of this gene is FBP1.

UniProtKB/Swiss-Prot for FBP2 Gene

  • Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBP2 Gene

Genomics for FBP2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FBP2 Gene

Enhancers for FBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G094629 1 ENCODE 17.8 -37.6 -37558 4.4 PKNOX1 FOXA2 ATF1 MLX SIN3A ZNF48 YY1 SP5 ZHX2 MXD4 FBP2 MFSD14B FBP1
GH09G094662 1.3 Ensembl ENCODE 10.3 -72.6 -72591 7.5 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 TCF12 FBP1 FBP2 PIR42796
GH09G094623 0.9 ENCODE 11.4 -29.6 -29592 0.1 ELF3 PKNOX1 CBX3 ARID4B RAD21 ZNF143 CREM MIXL1 THAP11 KLF11 FBP2 FBP1
GH09G094672 0.9 Ensembl ENCODE 10.6 -80.8 -80752 4.1 CEBPB NR2F2 ZNF7 RFX5 ZNF664 JUND ATF3 MAFK FBP1 FBP2 FANCC PIR42796
GH09G094602 1.1 Ensembl ENCODE 7.9 -10.2 -10225 2.7 ELF3 ATF1 WRNIP1 ARID4B RAD21 ZEB1 RARA ZNF143 CREM ZNF654 FBP1 MFSD14B FBP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FBP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FBP2 gene promoter:

Genomic Location for FBP2 Gene

Chromosome:
9
Start:
94,558,714 bp from pter
End:
94,593,832 bp from pter
Size:
35,119 bases
Orientation:
Minus strand

Genomic View for FBP2 Gene

Genes around FBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FBP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FBP2 Gene

Proteins for FBP2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00757-F16P2_HUMAN
    Recommended name:
    Fructose-1,6-bisphosphatase isozyme 2
    Protein Accession:
    O00757
    Secondary Accessions:
    • Q17R39
    • Q6FI53

    Protein attributes for FBP2 Gene

    Size:
    339 amino acids
    Molecular mass:
    36743 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.
    Miscellaneous:
    • Specific for the alpha-anomer of the substrate (PubMed:22120740). The Arg-33 mutant form has been shown to act on the beta-anomer (PubMed:24086250).

    Three dimensional structures from OCA and Proteopedia for FBP2 Gene

neXtProt entry for FBP2 Gene

Protein Expression for FBP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FBP2 Gene

O00757:
  • AGYALYG
  • HQRVPLI
  • GGIFLYP
  • EYVQKKKFPEDGS
  • KLDVLSN
  • VKIKKKG
  • YPANQKSP
  • TCVLVSEE
  • DPLDGSS
  • GKLRLLYE
  • DPLDGSSN
  • SLNEGYAK
  • GTGELTQLLNS
  • HRTLVYGGIF
  • PYGARYVGS

Post-translational modifications for FBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FBP2 Gene

Gene Families for FBP2 Gene

HGNC:

Protein Domains for FBP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00757

UniProtKB/Swiss-Prot:

F16P2_HUMAN :
  • Belongs to the FBPase class 1 family.
Family:
  • Belongs to the FBPase class 1 family.
genes like me logo Genes that share domains with FBP2: view

Function for FBP2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FBP2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.3 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:16213487, ECO:0000269 PubMed:17350621}; KM=2.6 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:16213487, ECO:0000269 PubMed:17350621}; Note=The kinetic constants are determined for the recombinant enzyme expressed in E.coli.;
UniProtKB/Swiss-Prot CatalyticActivity:
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose 2,6-bisphosphate acts as competitive inhibitor. Strongly inhibited by Ca(2+).
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

Enzyme Numbers (IUBMB) for FBP2 Gene

Gene Ontology (GO) - Molecular Function for FBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity IBA,TAS --
GO:0042578 phosphoric ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with FBP2: view
genes like me logo Genes that share phenotypes with FBP2: view

Animal Models for FBP2 Gene

MGI Knock Outs for FBP2:
  • Fbp2 tm2b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for FBP2

miRNA for FBP2 Gene

miRTarBase miRNAs that target FBP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FBP2 Gene

Localization for FBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBP2 Gene

Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FBP2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 4
lysosome 1

Gene Ontology (GO) - Cellular Components for FBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with FBP2: view

Pathways & Interactions for FBP2 Gene

genes like me logo Genes that share pathways with FBP2: view

Pathways by source for FBP2 Gene

2 BioSystems pathways for FBP2 Gene
1 GeneGo (Thomson Reuters) pathway for FBP2 Gene

UniProtKB/Swiss-Prot O00757-F16P2_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis.

Gene Ontology (GO) - Biological Process for FBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005986 sucrose biosynthetic process IBA --
GO:0006000 fructose metabolic process TAS 9678974
GO:0006002 fructose 6-phosphate metabolic process IBA --
GO:0006094 gluconeogenesis IBA,TAS --
genes like me logo Genes that share ontologies with FBP2: view

No data available for SIGNOR curated interactions for FBP2 Gene

Drugs & Compounds for FBP2 Gene

Products:

  1. Drug

(14) Drugs for FBP2 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
MB07803 Investigational Pharma inhibitor 0
MB05032 Pharma GNG inhibitor,special and efficacious 0

(20) Additional Compounds for FBP2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-D-Fructose 1,6-bisphosphate
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
  • D-Fructose 1,6-bis(dihydrogen phosphate)
  • D-Fructose 1,6-bisphosphate
  • D-Fructose 1,6-diphosphate
  • D-Fructose-1,6-bisphosphate
 488-69-7
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
 643-13-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
 14265-44-2

(1) ApexBio Compounds for FBP2 Gene

Compound Action Cas Number
MB05032 GNG inhibitor,special and efficacious 261365-11-1
genes like me logo Genes that share compounds with FBP2: view

Transcripts for FBP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FBP2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBP2 Gene

Fructose-1,6-bisphosphatase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBP2 Gene

No ASD Table

Relevant External Links for FBP2 Gene

GeneLoc Exon Structure for
FBP2
ECgene alternative splicing isoforms for
FBP2

Expression for FBP2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FBP2 Gene

mRNA expression in normal human tissues for FBP2 Gene
mRNA expression by BioGPS for FBP2 GenemRNA expression by GTEx for FBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBP2 Gene

This gene is overexpressed in Muscle - Skeletal (x44.0) and Stomach (x5.9).

Protein differential expression in normal tissues from HIPED for FBP2 Gene

This gene is overexpressed in Tonsil (16.9), Liver, secretome (10.7), and Liver (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FBP2 Gene



Protein tissue co-expression partners for FBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FBP2 Gene:

FBP2

SOURCE GeneReport for Unigene cluster for FBP2 Gene:

Hs.61255

mRNA Expression by UniProt/SwissProt for FBP2 Gene:

O00757-F16P2_HUMAN
Tissue specificity: Expressed in skeletal muscle (at protein level).

Evidence on tissue expression from TISSUES for FBP2 Gene

  • Muscle(4.7)
  • Intestine(4.1)
  • Liver(2.6)
genes like me logo Genes that share expression patterns with FBP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FBP2 Gene

Orthologs for FBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FBP2 34 35
  • 98.92 (n)
oppossum
(Monodelphis domestica)
 Mammalia FBP2 35
  • 92 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia FBP2 34 35
  • 91.03 (n)
dog
(Canis familiaris)
 Mammalia FBP2 34 35
  • 89.74 (n)
rat
(Rattus norvegicus)
 Mammalia Fbp2 34
  • 88.36 (n)
mouse
(Mus musculus)
 Mammalia Fbp2 34 16 35
  • 87.18 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia FBP2 35
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FBP2 34 35
  • 78.76 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia fbp2 34
  • 75.02 (n)
zebrafish
(Danio rerio)
 Actinopterygii fbp2 34 35
  • 70.05 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8304 34
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009173 34
  • 62.35 (n)
fruit fly
(Drosophila melanogaster)
 Insecta fbp 36 34 35
  • 61.65 (n)
worm
(Caenorhabditis elegans)
 Secernentea fbp-1 34 35
  • 60.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FBP1 35
  • 42 (a)
 OneToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G43670 34
  • 56.84 (n)
rice
(Oryza sativa)
 Liliopsida Os01g0866400 34
  • 59.29 (n)
Os.3408 34
wheat
(Triticum aestivum)
 Liliopsida Ta.439 34
corn
(Zea mays)
 Liliopsida Zm.13437 34
Species where no ortholog for FBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FBP2 Gene

ENSEMBL:
Gene Tree for FBP2 (if available)
TreeFam:
Gene Tree for FBP2 (if available)

Paralogs for FBP2 Gene

Paralogs for FBP2 Gene

(1) SIMAP similar genes for FBP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FBP2 Gene

genes like me logo Genes that share paralogs with FBP2: view

Variants for FBP2 Gene

Sequence variations from dbSNP and Humsavar for FBP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000039798 -- 94,586,955(+) AAGGC(A/G)GGGCG intron-variant
rs1000112151 -- 94,559,322(+) CACTC(A/C)TCCAG intron-variant
rs1000204080 -- 94,567,204(+) AAGCC(A/G)CCACC intron-variant
rs1000265667 -- 94,563,396(+) TAGAC(C/G)AGGGT intron-variant, reference, synonymous-codon
rs1000340330 -- 94,563,696(+) AGACA(A/G)TATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1493e214 CNV gain 21293372
esv25230 CNV loss 19812545
esv2761545 CNV gain 21179565
esv3576685 CNV gain 25503493
esv3621113 CNV gain 21293372
nsv1124452 CNV deletion 24896259
nsv1147999 OTHER inversion 26484159
nsv466436 CNV loss 19166990
nsv521698 CNV loss 19592680
nsv614917 CNV loss 21841781

Variation tolerance for FBP2 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBP2 Gene

Disorders for FBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FBP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fructose-1,6-bisphosphatase deficiency
  • fructose 1 phosphate aldolase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search FBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FBP2

Genetic Association Database (GAD)
FBP2
Human Genome Epidemiology (HuGE) Navigator
FBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FBP2
genes like me logo Genes that share disorders with FBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FBP2 Gene

Publications for FBP2 Gene

  1. Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase. (PMID: 18214967) Gizak A. … Rakus D. (Proteins 2008) 3 4 22 64
  2. The origin of the high sensitivity of muscle fructose 1,6- bisphosphatase towards AMP. (PMID: 16213487) Rakus D. … Dzugaj A. (FEBS Lett. 2005) 3 4 22 64
  3. Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase. (PMID: 9678974) Tillman H. … Eschrich K. (Gene 1998) 2 3 4 64
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim J.J. … Lee J.K. (J. Hum. Genet. 2010) 3 46 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for FBP2 Gene

Sources for FBP2 Gene

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