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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBP2 Gene

protein-coding   GIFtS: 64
GCID: GC09M097321

Fructose-1,6-Bisphosphatase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fructose-1,6-Bisphosphatase 21 2     Fructose-1,6-Bisphosphatase Isozyme 22
D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 22 3     hexosediphosphatase2
FBPase 22 3     Muscle Fructose-Bisphosphatase2
EC 3.1.3.113 8     EC 3.1.38

External Ids:    HGNC: 36071   Entrez Gene: 87892   Ensembl: ENSG000001309577   OMIM: 6030275   UniProtKB: O007573   

Export aliases for FBP2 gene to outside databases

Previous GC identifers: GC09M088147 GC09M089048 GC09M090621 GC09M092662 GC09M094400 GC09M096360 GC09M066929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FBP2 Gene:
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate
to fructose 6-phosphate and inorganic phosphate. (provided by RefSeq, Jul 2008)

GeneCards Summary for FBP2 Gene: 
FBP2 (fructose-1,6-bisphosphatase 2) is a protein-coding gene. Diseases associated with FBP2 include fructose-1,6-bisphosphatase deficiency, and glycogen storage disease type 1a, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Metabolic pathways. GO annotations related to this gene include fructose-2,6-bisphosphate 2-phosphatase activity and fructose 1,6-bisphosphate 1-phosphatase activity. An important paralog of this gene is FBP1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBP2 gene promoter:
         AML1a   NRSF form 1   NCX/Ncx   Pax-2   Pax-2a   LCR-F1   NRSF form 2   E47   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.3

FBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBP2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M097321:  view genomic region     (about GC identifiers)

Start:
97,321,002 bp from pter      End:
97,356,075 bp from pter
Size:
35,074 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757 (See protein sequence)
Recommended Name: Fructose-1,6-bisphosphatase isozyme 2  
Size: 339 amino acids; 36743 Da
Cofactor: Binds 3 magnesium ions per subunit (By similarity)
Subunit: Homotetramer (By similarity)
2 PDB 3D structures from and Proteopedia for FBP2:
3IFA (3D)        3IFC (3D)    
Secondary accessions: Q17R39 Q6FI53

Explore the universe of human proteins at neXtProt for FBP2: NX_O00757

Explore proteomics data for FBP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00757

  • 4/15 DME Specific Peptides for FBP2 (O00757) (see all 15)
     VKIKKKG  AGYALYG  HQRVPLI  DPLDGSS 

    FBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FBP2 Protein Expression
    REFSEQ proteins: NP_003828.2  
    ENSEMBL proteins: 
     ENSP00000364486  
    Reactome Protein details: O00757
    Human Recombinant Protein Products for FBP2: 
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    Novus Biologicals FBP2 Proteins
    Novus Biologicals FBP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for FBP2
    Cloud-Clone Corp. Proteins for FBP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    FBP2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for FBP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR020548 Fructose_bisphosphatase_AS
     IPR000146 FBPase_class-1/SBPase

    Graphical View of Domain Structure for InterPro Entry O00757

    ProtoNet protein and cluster: O00757

    1 Blocks protein domain: IPB000146 Inositol phosphatase/fructose-1,6-bisphosphatase

    UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757
    Similarity: Belongs to the FBPase class 1 family


    FBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: F16P2_HUMAN, O00757
    Catalytic activity: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
    Enzyme regulation: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an
    inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose
    2,6-bisphosphate acts as competitive inhibitor
    Biophysicochemical properties: Kinetic parameters: KM=1.3 uM for fructose 1,6-biphosphate;

         Enzyme Numbers (IUBMB): EC 3.1.3.111 2 EC 3.1.32

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity TAS9678974
    GO:0042132fructose 1,6-bisphosphate 1-phosphatase activity IEA--
    GO:0042578phosphoric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    FBP2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FBP2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Glycolysis / Gluconeogenesis0.46
    Glycolysis and Gluconeogenesis0.60
    gluconeogenesis0.39
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Glucose metabolism
    Glucose metabolism0.50
    Gluconeogenesis0.50
    4MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48
    5Carbon metabolism
    Carbon metabolism0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for FBP2
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for FBP2
        Glycolysis and gluconeogenesis (short map)

    2 BioSystems Pathways for FBP2
        Glycolysis and Gluconeogenesis
    gluconeogenesis


    4        Reactome Pathways for FBP2
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism


    5/6         Kegg Pathways  (Kegg details for FBP2) (see all 6):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757
    Pathway: Carbohydrate biosynthesis; gluconeogenesis


    FBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for FBP2 (O007572, 3 ENSP000003644864) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-64591 I2D: score=5 
    ALDOAENSP000003369274STRING: ENSP00000336927
    ALDOBENSP000003639884STRING: ENSP00000363988
    ALDOCENSP000002262534STRING: ENSP00000226253
    C12orf5ENSP000001792594STRING: ENSP00000179259
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process TAS9678974
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0044281small molecule metabolic process TAS--

    FBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBP2 (F16P2)

    4 HMDB Compounds for FBP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    Fructose 1,6-bisphosphateD-Fructose 1,6-biphosphate (see all 16)488-69-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/25 Novoseek inferred chemical compound relationships for FBP2 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 80.9 31 12654061 (2), 8034042 (1), 15498578 (1), 15965961 (1) (see all 29)
    fructose-6-phosphate 68.6 3 18650089 (1), 11023824 (1), 10892022 (1)
    phosphonate 59.6 3 18041834 (2), 18570362 (1)
    cystamine 54.9 1 8019428 (1)
    fructose-1,6-bisphosphate 51.7 13 15554702 (5), 18650089 (1), 10892022 (1)
    phosphoenolpyruvate 50.1 3 14502558 (1), 15556076 (1), 17633477 (1)
    dhap 48.6 2 8144170 (1), 10892022 (1)
    glucose 44.9 46 16980436 (7), 15358789 (4), 15527777 (3), 11522786 (2) (see all 21)
    adenylate 31.9 3 17253638 (1), 17659484 (1), 16213487 (1)
    lead 29.7 3 18041834 (1), 20069623 (1), 15911772 (1)

    Search CenterWatch for drugs/clinical trials and news about FBP2 / F16P2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FBP2 gene: 
    NM_003837.3  

    Unigene Cluster for FBP2:

    Fructose-1,6-bisphosphatase 2
    Hs.61255  [show with all ESTs]
    Unigene Representative Sequence: NM_003837
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375337(uc004auv.3)
    miRNA
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    Additional mRNA sequence: 

    BC113632.1 BC117477.1 CR536483.1 Y10812.2 

    2 DOTS entries:

    DT.109991  DT.100007920 

    24/25 AceView cDNA sequences (see all 25):

    F36375 NM_003837 F25823 CR536483 F32342 F22220 BU727940 AW418781 
    Y10812 AI580930 AJ573829 BM686555 AA025150 BX095179 F30527 AI312605 
    F35125 AI031954 F24658 BG194719 BG215204 F25416 AI800916 F16656 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBP2 expression in normal human tissues (normalized intensities)      FBP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAAAAAA
    FBP2 Expression
    About this image


    FBP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Loop of Henle Cells Loop of Henle
             Proximal Tubule
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See FBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBP2

    SOURCE GeneReport for Unigene cluster: Hs.61255
        SABiosciences Expression via Pathway-Focused PCR Array including FBP2: 
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FBP2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fbp21 , 5 fructose bisphosphatase 21, 5 87.18(n)1
    94.38(a)1
      13 (32.74 cM)5
    141201  NM_007994.31  NP_032020.21 
     628368855 
    chicken
    (Gallus gallus)
    Aves FBP21 fructose-1,6-bisphosphatase 2 78.76(n)
    86.43(a)
      395217  XM_425039.3  XP_425039.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053267.12   -- 75.3(n)    BC053267.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fbp3 fructose-bisphosphatase 61(a)   38A4   --
    worm
    (Caenorhabditis elegans)
    Secernentea fbp-16
    Protein FBP-1
    60(a)
    1 → many
    I(2580935-2586126)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FBP16
    Fructose-1,6-bisphosphatase, key regulatory enzyme...
    43(a)
    1 → many
    XII(873746-874792)
    rice
    (Oryza sativa)
    Liliopsida Os.34082 Oryza sativa mRNA for fructose-1,6-bisphosphatase (cytosolic more 76.48(n)    AB007193.1 


    ENSEMBL Gene Tree for FBP2 (if available)
    TreeFam Gene Tree for FBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBP2 gene
    FBP12  
    1 SIMAP similar gene for FBP2 using alignment to 4 protein entries:     F16P2_HUMAN (see all proteins):
    FBP1

    FBP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FBP2
    PGOHUM00000236239 PGOHUM00000236240


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/935 SNPs in FBP2 are shown (see all 935)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714940301,2
    C,F--66944451(-) AAAAA-/AG/G/T
            
    AAACT
    1 -- int12NA CSA 4
    rs1914498501,2
    --97320525(+) GAGGTA/TATCAC 1 -- ds50010--------
    rs797793691,2
    C,F--97320536(+) TACAGG/TATAAG 1 -- ds50011Minor allele frequency- T:0.05EA 120
    rs727432431,2
    C--97320607(+) AATCTC/GACTCT 1 -- ds50010--------
    rs1438886601,2
    --97320613(+) ACTCTC/GTCACC 1 -- ds50010--------
    rs1474072941,2
    --97320645(+) GATCTC/TGGCTC 1 -- ds50010--------
    rs1826866861,2
    --97320725(+) GCGCCC/TGCCAC 1 -- ds50010--------
    rs107613341,2
    C,F,A--97320726(+) CGCCCA/GCCACC 1 -- ds50015Minor allele frequency- G:0.40NA 10
    rs1856875761,2
    --97320797(+) GTCTCC/GATCTC 1 -- ds50010--------
    rs1114085691,2
    C--97320862(+) GAGCCG/ACCGCA 1 -- ds50011Minor allele frequency- A:0.00CSA 1

    HapMap Linkage Disequilibrium report for FBP2 (97321002 - 97356075 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FBP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv466436CNV Loss19166990
    nsv521698CNV Loss19592680
    esv25230CNV Loss19812545
    nsv893596CNV Gain21882294
    nsv893595CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603027    OMIM disorders: --

    13 diseases for FBP2:    About MalaCards
    fructose-1,6-bisphosphatase deficiency    glycogen storage disease type 1a    glycogen storage disease    type 1 diabetes mellitus
    hypoglycemia    type 1 diabetes    astrocytoma    diabetes mellitus
    hypoxia    ischemia    obesity    pancreatitis
    hepatitis


    FBP2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FBP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoglycemia 34.9 5 12654061 (3), 17705024 (2)
    cancer 0 6 16680461 (3), 18938139 (2), 15474002 (1)

    Genetic Association Database (GAD): FBP2
    Human Genome Epidemiology (HuGE) Navigator: FBP2 (1 document)

    Export disorders for FBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBP2 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with FBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase. (PubMed id 9678974)1, 2, 3 Tillman H. and Eschrich K. (1998)
    2. The origin of the high sensitivity of muscle fructose 1,6- bisphosphatase towards AMP. (PubMed id 16213487)1, 2, 9 Rakus D....Dzugaj A. (2005)
    3. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1, 4 Kim J.J....Lee J.K. (2010)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase. (PubMed id 18214967)1, 9 Gizak A....Rakus D. (2008)
    8. Structure and chromosomal localization of the human and mouse muscle fructose-1,6-bisphosphatase genes. (PubMed id 10773464)1, 9 Tillmann H.... Eschrich K. (2000)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8789 HGNC: 3607 AceView: FBP2 Ensembl:ENSG00000130957 euGenes: HUgn8789
    ECgene: FBP2 Kegg: 8789 H-InvDB: FBP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FBP2 gene:
    Search GeneIP for patents involving FBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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