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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FBP2 Gene

protein-coding   GIFtS: 62
GCID: GC09M097321

fructose-1,6-bisphosphatase 2
 Explore 13 diseases affiliated with
FBP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FBP2    

Aliases
for FBP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fructose-1,6-Bisphosphatase 21 2     Fructose-1,6-Bisphosphatase Isozyme 22
D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 22 3     Hexosediphosphatase1
FBPase 22 3     Muscle Fructose-Bisphosphatase2
EC 3.1.3.113 8     EC 3.1.38

External Ids:    HGNC: 36071   Entrez Gene: 87892   Ensembl: ENSG000001309577   OMIM: 6030275   UniProtKB: O007573   

Export aliases for FBP2 gene to outside databases

Previous GC identifers: GC09M088147 GC09M089048 GC09M090621 GC09M092662 GC09M094400 GC09M096360 GC09M066929


Summaries
for FBP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FBP2:
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to
fructose 6-phosphate and inorganic phosphate. (provided by RefSeq, Jul 2008)




Genomic Views
for FBP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FBP2 gene promoter:
         AML1a   NRSF form 1   NCX/Ncx   Pax-2   Pax-2a   LCR-F1   NRSF form 2   E47   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.3

FBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FBP2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M097321:  view genomic region     (about GC identifiers)

Start:
 97,321,002 bp from pter      End:
 97,356,075 bp from pter
Size:
 35,074 bases      Orientation:
 minus strand

Proteins
for FBP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757 (See protein sequence)
Recommended Name: Fructose-1,6-bisphosphatase isozyme 2  
Size: 339 amino acids; 36743 Da
Cofactor: Binds 3 magnesium ions per subunit (By similarity)
Subunit: Homotetramer (By similarity)
2 PDB 3D structures from and Proteopedia for FBP2:
3IFA (3D)        3IFC (3D)    
Secondary accessions: Q17R39 Q6FI53

Explore the universe of human proteins at neXtProt for FBP2: NX_O00757

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00757

    • 4/15 DME Specific Peptides for FBP2 (O00757) (see all 15)
     VKIKKKG  AGYALYG  HQRVPLI  DPLDGSS 

    FBP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003828.2  
    ENSEMBL proteins: 
     ENSP00000364486  
    Reactome Protein details: O00757
    Human Recombinant Protein Products: 
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    Novus Biologicals FBP2 Proteins
    Novus Biologicals FBP2 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FBP2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    FBP2 for ontologies           About GeneDecksing



    FBP2 Antibody Products: 
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    Uscn ELISAs and CLIAs for FBP2

    Protein Domains /
    Families
    for FBP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FBP2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR020548 Fructose_bisphosphatase_AS
     IPR000146 FBPase_class-1/SBPase

    Graphical View of Domain Structure for InterPro Entry O00757

    ProtoNet protein and cluster: O00757

    1 Blocks protein family: IPB000146 Inositol phosphatase/fructose-1,6-bisphosphatase

    UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757
    Similarity: Belongs to the FBPase class 1 family


    Function
    for FBP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757
    Catalytic activity: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
    Enzyme regulation: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive
    T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose 2,6-bisphosphate acts as
    competitive inhibitor
    Biophysicochemical properties: Kinetic parameters: KM=1.3 uM for fructose 1,6-biphosphate;

    Enzyme Numbers (IUBMB): EC 3.1.3.111 2 EC 3.1.32

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: FBP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for FBP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FBP2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity TAS9678974
    GO:0042132fructose 1,6-bisphosphate 1-phosphatase activity IEA--
    GO:0046872metal ion binding IEA--


    FBP2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for FBP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycolysis and gluconeogenesis (short map)
    		Glycolysis and gluconeogenesis (short map)1.00
    		Glycolysis and Gluconeogenesis0.60
    		Glycolysis and gluconeogenesis (short map)0.97
    		Glycolysis / Gluconeogenesis0.41
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3gluconeogenesis I
    		gluconeogenesis I1.00
    		glycolysis I0.58
    4Glucose metabolism
    		Glucose metabolism1.00
    		Gluconeogenesis0.50
    5Fructose and mannose metabolism
    		Fructose and mannose metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for FBP2
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for FBP2
        Glycolysis and gluconeogenesis (short map)

    3 BioSystems Pathways for FBP2 
        Glycolysis and Gluconeogenesis
    glycolysis I
    gluconeogenesis I

    4        Reactome Pathways for FBP2
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism


    5         Kegg Pathways  (Kegg details for FBP2):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Metabolic pathways
    Insulin signaling pathway

    UniProtKB/Swiss-Prot: F16P2_HUMAN, O00757
    Pathway: Carbohydrate biosynthesis; gluconeogenesis


    FBP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for FBP2 (O007572, 3 ENSP000003644864) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-64591 I2D: score=5 
    ALDOAENSP000003369274STRING: ENSP00000336927
    ALDOBENSP000003639884STRING: ENSP00000363988
    ALDOCENSP000002262534STRING: ENSP00000226253
    C12orf5ENSP000001792594STRING: ENSP00000179259
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process TAS9678974
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--
    GO:0044281small molecule metabolic process TAS--


    FBP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FBP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FBP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FBP2

    4 HMDB Compounds for FBP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    Fructose 1,6-bisphosphateD-Fructose 1,6-biphosphate (see all 16)488-69-7--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    10/25 Novoseek chemical compound relationships for FBP2 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 80.9 31 12654061 (2), 8034042 (1), 15498578 (1), 15965961 (1) (see all 29)
    fructose-6-phosphate 68.6 3 18650089 (1), 11023824 (1), 10892022 (1)
    phosphonate 59.6 3 18041834 (2), 18570362 (1)
    cystamine 54.9 1 8019428 (1)
    fructose-1,6-bisphosphate 51.7 13 15554702 (5), 18650089 (1), 10892022 (1)
    phosphoenolpyruvate 50.1 3 14502558 (1), 15556076 (1), 17633477 (1)
    dhap 48.6 2 8144170 (1), 10892022 (1)
    glucose 44.9 46 16980436 (7), 15358789 (4), 15527777 (3), 11522786 (2) (see all 21)
    adenylate 31.9 3 17253638 (1), 17659484 (1), 16213487 (1)
    lead 29.7 3 18041834 (1), 20069623 (1), 15911772 (1)

    Search CenterWatch for drugs/clinical trials and news about FBP2 / F16P2 

    Transcripts
    for FBP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FBP2 gene: 
    NM_003837.2  

    Unigene Cluster for FBP2:

    Fructose-1,6-bisphosphatase 2
    Hs.61255  [show with all ESTs]
    Unigene Representative Sequence: NM_003837
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375337(uc004auv.3)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FBP2 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC113632.1 BC117477.1 CR536483.1 Y10812.2 

    2 DOTS entries:

    DT.109991  DT.100007920 

    24/25 AceView cDNA sequences (see all 25):

    CR536483 F36375 NM_003837 F25823 BU727940 F32342 BX095179 AI580930 
    Y10812 F22220 AJ573829 BM686555 AA025150 AW418781 AI312605 F24658 
    F35125 BG194719 F30527 AI031954 F25416 BG215204 AI800916 W32956 

    GeneLoc Exon Structure


    Expression
    for FBP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FBP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    BoneZeugopod Epiphyseal EndBone
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FBP2

    SOURCE GeneReport for Unigene cluster: Hs.61255
        SABiosciences Expression via Pathway-Focused PCR Array including FBP2: 
              Glucose Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for FBP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for FBP2 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FBP21 fructose-1,6-bisphosphatase 2 78.76(n)
    86.43(a)    		   395217  XM_425039.3  XP_425039.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FBP26
    		 --
    		 88(a)
    		 1 ↔ 1
    		 2(40903042-40917518)
    zebrafish
    (Danio rerio)    		 Actinopterygii BC053267.12   -- 75.3(n)    BC053267.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fbp3 fructose-bisphosphatase 61(a)   38A4   --
    worm
    (Caenorhabditis elegans)    		 Secernentea fbp-16
    		 Fructose-1,6-BiPhosphatase family member (fbp-1)
    		 60(a)
    		 1 → many
    		 I(2580937-2586128)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G436706
    HCEF16
    (see all 4)    		 fructose-1,6-bisphosphatase
    (see all 4)    		 53(a)
    35(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 1(16468044-16470500)
    3(20016892-20018822)
    rice
    (Oryza sativa)    		 Liliopsida Os.34082 Oryza sativa mRNA for fructose-1,6-bisphosphatase (cytosolic more 76.48(n)    AB007193.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria fbp6
    		 fructose-1,6-bisphosphatase I
    		 40(a)
    		 possible ortholog
    		 Chromosome(4452634-4453632)


    ENSEMBL Gene Tree for FBP2 (if available)
    TreeFam Gene Tree for FBP2 (if available) 

    Paralogs
    for FBP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FBP2 gene
    FBP12  
    1 SIMAP similar gene for FBP2 using alignment to 4 protein entries:     F16P2_HUMAN (see all proteins):
    FBP1

    FBP2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for FBP2
    PGOHUM00000236239 PGOHUM00000236240


    Genomic Variants
    for FBP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/783 NCBI SNPs in FBP2 are shown (see all 783)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1914498501,2
    		--97320525(+) GAGGTA/TATCAC 1 -- ds50010--------
    rs797793691,2
    		F,--97320536(+) TACAGG/TATAAG 1 -- ds50011Minor allele frequency- T:0.05EA 120
    rs727432431,2
    		C--97320607(+) AATCTC/GACTCT 1 -- ds50010--------
    rs1438886601,2
    		--97320613(+) ACTCTC/GTCACC 1 -- ds50010--------
    rs1474072941,2
    		--97320645(+) GATCTC/TGGCTC 1 -- ds50010--------
    rs1826866861,2
    		--97320725(+) GCGCCC/TGCCAC 1 -- ds50010--------
    rs107613341,2
    		C,F,A,--97320726(+) CGCCCA/GCCACC 1 -- ds50015Minor allele frequency- G:0.40NA 10
    rs1856875761,2
    		--97320797(+) GTCTCC/GATCTC 1 -- ds50010--------
    rs1114085691,2
    		--97320862(+) GAGCCG/ACCGCA 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs27720131,2
    		C,F,A,--97320865(-) GGGTGC/TGGTGG 1 -- ds50015Minor allele frequency- T:0.39NA 128

    HapMap Linkage Disequilibrium report for FBP2 (97321002 - 97356075 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for FBP2
         1 Indel: 65461

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    Disorders / Diseases
    for FBP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FBP2 for disorders           About GeneDecksing

    OMIM gene information: 603027    OMIM disorders: --

    13 diseases for FBP2:    About MalaCards
    fructose-1,6-bisphosphatase deficiency    glycogen storage disease type 1a    glycogen storage disease    type 1 diabetes mellitus
    diabetes mellitus    embryonal carcinoma    astrocytoma    ischemia
    obesity    hypoxia    carcinoma    pancreatitis
    hepatitis

    2 Novoseek disease relationships for FBP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypoglycemia 34.9 5 12654061 (3), 17705024 (2)
    cancer 0 6 16680461 (3), 18938139 (2), 15474002 (1)

    Human Genome Epidemiology (HuGE) Navigator: FBP2 (1 document)

    Export disorders for FBP2 gene to outside databases

    Publications
    for FBP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FBP2 gene, integrated from 9 sources (see all 111):
    (articles sorted by number of sources associating them with FBP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase. (PubMed id 9678974)1, 2, 3 Tillman H. and Eschrich K. (1998)
    2. The origin of the high sensitivity of muscle fructose 1,6- bisphosphatase towards AMP. (PubMed id 16213487)1, 2, 9 Rakus D....Dzugaj A. (2005)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase. (PubMed id 18214967)1, 9 Gizak A....Rakus D. (2008)
    6. Structure and chromosomal localization of the human and mouse muscle fructose-1,6-bisphosphatase genes. (PubMed id 10773464)1, 9 Tillmann H.... Eschrich K. (2000)
    7. Identification of 15 loci influencing height in a Kor ean population. (PubMed id 19893584)1 Kim J.J....Lee J.K. (2010)
    8. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for FBP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FBP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8789 HGNC: 3607 AceView: FBP2 Ensembl:ENSG00000130957 euGenes: HUgn8789
    ECgene: FBP2 Kegg: 8789 H-InvDB: FBP2

    Other Databases showing FBP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FBP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FBP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FBP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FBP2 gene:
    Search GeneIP for patents involving FBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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