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Aliases for FBP2 Gene

Aliases for FBP2 Gene

  • Fructose-1,6-Bisphosphatase 2 2 3
  • D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 2 3 4
  • Muscle FBPase 3 4
  • EC 4 64
  • FBPase 2 3 4
  • Fructose-1,6-Bisphosphatase Isozyme 2 3
  • Muscle Fructose-Bisphosphatase 3
  • Hexosediphosphatase 3
  • EC 3.1.3 64

External Ids for FBP2 Gene

Summaries for FBP2 Gene

Entrez Gene Summary for FBP2 Gene

  • This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBP2 Gene

FBP2 (Fructose-1,6-Bisphosphatase 2) is a Protein Coding gene. Diseases associated with FBP2 include fructose-1,6-bisphosphatase deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include fructose-2,6-bisphosphate 2-phosphatase activity and fructose 1,6-bisphosphate 1-phosphatase activity. An important paralog of this gene is FBP1.

UniProtKB/Swiss-Prot for FBP2 Gene

  • Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBP2 Gene

Genomics for FBP2 Gene

Genomic Location for FBP2 Gene

94,558,714 bp from pter
94,593,832 bp from pter
35,119 bases
Minus strand

Genomic View for FBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBP2 Gene

Regulatory Elements for FBP2 Gene

Proteins for FBP2 Gene

  • Protein details for FBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fructose-1,6-bisphosphatase isozyme 2
    Protein Accession:
    Secondary Accessions:
    • Q17R39
    • Q6FI53

    Protein attributes for FBP2 Gene

    339 amino acids
    Molecular mass:
    36743 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 3 Mg(2+) ions per subunit.;
    Quaternary structure:
    • Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.
    • Specific for the alpha-anomer of the substrate (PubMed:22120740). The Arg-33 mutant form has been shown to act on the beta-anomer (PubMed:24086250).

    Three dimensional structures from OCA and Proteopedia for FBP2 Gene

neXtProt entry for FBP2 Gene

Proteomics data for FBP2 Gene at MOPED

Post-translational modifications for FBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for FBP2 Gene


  • Belongs to the FBPase class 1 family.:
    • O00757
genes like me logo Genes that share domains with FBP2: view

No data available for Gene Families for FBP2 Gene

Function for FBP2 Gene

Molecular function for FBP2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.3 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:16213487, ECO:0000269 PubMed:17350621}; KM=2.6 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:16213487, ECO:0000269 PubMed:17350621}; Note=The kinetic constants are determined for the recombinant enzyme expressed in E.coli.;
UniProtKB/Swiss-Prot CatalyticActivity: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose 2,6-bisphosphate acts as competitive inhibitor. Strongly inhibited by Ca(2+).
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

Enzyme Numbers (IUBMB) for FBP2 Gene

Gene Ontology (GO) - Molecular Function for FBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity IEA --
GO:0042578 phosphoric ester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FBP2: view

miRNA for FBP2 Gene

miRTarBase miRNAs that target FBP2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FBP2 Gene

Localization for FBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FBP2 Gene

Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for FBP2 Gene COMPARTMENTS Subcellular localization image for FBP2 gene
Compartment Confidence
cytosol 4
chloroplast 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0030018 Z disc IEA --
GO:0030054 cell junction IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FBP2: view

Pathways for FBP2 Gene

genes like me logo Genes that share pathways with FBP2: view

Pathways by source for FBP2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for FBP2 Gene
2 BioSystems pathways for FBP2 Gene

UniProtKB/Swiss-Prot O00757-F16P2_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis

Gene Ontology (GO) - Biological Process for FBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006000 fructose metabolic process TAS 9678974
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with FBP2: view

Compounds for FBP2 Gene

(4) HMDB Compounds for FBP2 Gene

Compound Synonyms Cas Number PubMed IDs
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Not Available
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
  • NFB Orthophosphate
  • Dihydrogen oxide

(25) Novoseek inferred chemical compound relationships for FBP2 Gene

Compound -log(P) Hits PubMed IDs
fructose 80.9 30
fructose-6-phosphate 68.6 3
phosphonate 59.6 3
cystamine 54.9 1
fructose-1,6-bisphosphate 51.7 7
genes like me logo Genes that share compounds with FBP2: view

Transcripts for FBP2 Gene

mRNA/cDNA for FBP2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FBP2 Gene

Fructose-1,6-bisphosphatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FBP2 Gene

No ASD Table

Relevant External Links for FBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FBP2 Gene

mRNA expression in normal human tissues for FBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBP2 Gene

This gene is overexpressed in Muscle - Skeletal (44.0) and Stomach (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FBP2 Gene

SOURCE GeneReport for Unigene cluster for FBP2 Gene Hs.61255

mRNA Expression by UniProt/SwissProt for FBP2 Gene

Tissue specificity: Expressed in skeletal muscle (at protein level).
genes like me logo Genes that share expressions with FBP2: view

Orthologs for FBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FBP2 36
  • 98.92 (n)
  • 99.41 (a)
FBP2 37
  • 99 (a)
(Bos Taurus)
Mammalia FBP2 36
  • 91.03 (n)
  • 97.93 (a)
FBP2 37
  • 98 (a)
(Canis familiaris)
Mammalia FBP2 36
  • 89.74 (n)
  • 96.45 (a)
FBP2 37
  • 94 (a)
(Mus musculus)
Mammalia Fbp2 36
  • 87.18 (n)
  • 94.38 (a)
Fbp2 16
Fbp2 37
  • 94 (a)
(Monodelphis domestica)
Mammalia FBP2 37
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia FBP2 37
  • 63 (a)
(Rattus norvegicus)
Mammalia Fbp2 36
  • 88.36 (n)
  • 94.97 (a)
(Gallus gallus)
Aves FBP2 36
  • 78.76 (n)
  • 86.43 (a)
FBP2 37
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fbp2 36
  • 75.02 (n)
  • 84.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8304 36
(Danio rerio)
Actinopterygii fbp2 36
  • 70.05 (n)
  • 75.22 (a)
fbp2 37
  • 75 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009173 36
  • 62.35 (n)
  • 60.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta fbp 36
  • 61.65 (n)
  • 61.14 (a)
fbp 37
  • 56 (a)
fbp 38
  • 61 (a)
(Caenorhabditis elegans)
Secernentea fbp-1 36
  • 60.36 (n)
  • 61.86 (a)
fbp-1 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FBP1 37
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G43670 36
  • 56.84 (n)
  • 56.74 (a)
(Zea mays)
Liliopsida Zm.13437 36
(Oryza sativa)
Liliopsida Os.3408 36
Os01g0866400 36
  • 59.29 (n)
  • 56.7 (a)
(Triticum aestivum)
Liliopsida Ta.439 36
Species with no ortholog for FBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FBP2 Gene

Gene Tree for FBP2 (if available)
Gene Tree for FBP2 (if available)

Paralogs for FBP2 Gene

Paralogs for FBP2 Gene

Selected SIMAP similar genes for FBP2 Gene using alignment to 4 proteins: Pseudogenes for FBP2 Gene

genes like me logo Genes that share paralogs with FBP2: view

Variants for FBP2 Gene

Sequence variations from dbSNP and Humsavar for FBP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs479197 -- 94,576,062(-) ctgtc(C/T)gtctc intron-variant
rs498533 -- 94,569,581(-) TAAAA(C/T)TGTGG intron-variant
rs498635 -- 94,569,552(-) CTGAG(A/T)GTCCC intron-variant
rs499480 -- 94,590,186(-) CTTTC(A/C)CCCAT intron-variant
rs514222 -- 94,574,562(-) TTTGT(A/G)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FBP2 Gene

Variant ID Type Subtype PubMed ID
nsv893595 CNV Gain 21882294
nsv893596 CNV Gain 21882294
nsv521698 CNV Loss 19592680
esv25230 CNV Loss 19812545
nsv466436 CNV Loss 19166990

Relevant External Links for FBP2 Gene

HapMap Linkage Disequilibrium report

Disorders for FBP2 Gene

(2) Novoseek inferred disease relationships for FBP2 Gene

Disease -log(P) Hits PubMed IDs
hypoglycemia 34.9 5
cancer 0 6

Relevant External Links for FBP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FBP2: view

No data available for UniProtKB/Swiss-Prot for FBP2 Gene

Publications for FBP2 Gene

  1. The origin of the high sensitivity of muscle fructose 1,6- bisphosphatase towards AMP. (PMID: 16213487) Rakus D. … Dzugaj A. (FEBS Lett. 2005) 3 4 23
  2. Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase. (PMID: 18214967) Gizak A. … Rakus D. (Proteins 2008) 3 4 23
  3. Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase. (PMID: 9678974) Tillman H. … Eschrich K. (Gene 1998) 2 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FBP2 Gene

Sources for FBP2 Gene

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