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Aliases for FBP1 Gene

Aliases for FBP1 Gene

  • Fructose-1,6-Bisphosphatase 1 2 3
  • D-Fructose-1,6-Bisphosphate 1-Phosphohydrolase 1 3 4
  • Liver FBPase 3 4
  • EC 3.1.3.11 4 63
  • FBPase 1 3 4
  • FBP 3 4
  • Growth-Inhibiting Protein 17 3
  • Fructose-Bisphosphatase 1 3
  • EC 3.1.3 63

External Ids for FBP1 Gene

Previous HGNC Symbols for FBP1 Gene

  • FBP

Previous GeneCards Identifiers for FBP1 Gene

  • GC09M088192
  • GC09M089093
  • GC09M090664
  • GC09M092706
  • GC09M094444
  • GC09M096405
  • GC09M097365
  • GC09M066974

Summaries for FBP1 Gene

Entrez Gene Summary for FBP1 Gene

  • Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FBP1 Gene

FBP1 (Fructose-1,6-Bisphosphatase 1) is a Protein Coding gene. Diseases associated with FBP1 include fructose-1,6-bisphosphatase deficiency and metabolic acidosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding and monosaccharide binding. An important paralog of this gene is FBP2.

UniProtKB/Swiss-Prot for FBP1 Gene

  • Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FBP1 Gene

Genomics for FBP1 Gene

Regulatory Elements for FBP1 Gene

Transcription factor binding sites by QIAGEN in the FBP1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FBP1 Gene

Start:
94,603,133 bp from pter
End:
94,640,249 bp from pter
Size:
37,117 bases
Orientation:
Minus strand

Genomic View for FBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FBP1 Gene

Proteins for FBP1 Gene

  • Protein details for FBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09467-F16P1_HUMAN
    Recommended name:
    Fructose-1,6-bisphosphatase 1
    Protein Accession:
    P09467
    Secondary Accessions:
    • O75571
    • Q53F94
    • Q96E46

    Protein attributes for FBP1 Gene

    Size:
    338 amino acids
    Molecular mass:
    36842 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 3 Mg(2+) ions per subunit.;
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=AAC50207.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FBP1 Gene

neXtProt entry for FBP1 Gene

Proteomics data for FBP1 Gene at MOPED

Post-translational modifications for FBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for FBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P09467

UniProtKB/Swiss-Prot:

F16P1_HUMAN :
  • P09467
Family:
  • Belongs to the FBPase class 1 family.
genes like me logo Genes that share domains with FBP1: view

No data available for Gene Families for FBP1 Gene

Function for FBP1 Gene

Molecular function for FBP1 Gene

GENATLAS Biochemistry: fructose 1,6-bisphosphatase,hepatic,expressed in liver,fructose metabolism,neoglucogenesis,energy pathway
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.7 uM for fructose 1,6-biphosphate {ECO:0000269 PubMed:17350621}; Note=The kinetic constants are determined for the recombinant enzyme expressed in E.coli.;
UniProtKB/Swiss-Prot CatalyticActivity: D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. AMP binding affects the turnover of bound substrate and not the affinity for substrate. Fructose 2,6-bisphosphate acts as competitive inhibitor. Fructose 2,6-bisphosphate and AMP have synergistic effects.
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
UniProtKB/Swiss-Prot Induction: Up-regulated in pancreatic islets of individuals with type 2 diabetes.

Enzyme Numbers (IUBMB) for FBP1 Gene

Gene Ontology (GO) - Molecular Function for FBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10222032
GO:0016208 AMP binding IDA 10222032
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity IMP 19259699
GO:0042578 phosphoric ester hydrolase activity --
GO:0042802 identical protein binding IPI 16169070
genes like me logo Genes that share ontologies with FBP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FBP1 Gene

Localization for FBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FBP1 Gene COMPARTMENTS Subcellular localization image for FBP1 gene
Compartment Confidence
chloroplast 4
cytosol 4
nucleus 2
vacuole 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20096900
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FBP1 Gene

Pathways for FBP1 Gene

genes like me logo Genes that share pathways with FBP1: view

Pathways by source for FBP1 Gene

PCR Array Products

UniProtKB/Swiss-Prot P09467-F16P1_HUMAN

  • Pathway: Carbohydrate biosynthesis; gluconeogenesis

Gene Ontology (GO) - Biological Process for FBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006000 fructose metabolic process TAS 7558035
GO:0006002 fructose 6-phosphate metabolic process IDA 16442285
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
genes like me logo Genes that share ontologies with FBP1: view

Compounds for FBP1 Gene

(5) HMDB Compounds for FBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Not Available
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
488-69-7
Fructose 6-phosphate
  • D-Fructose 6-phosphate
643-13-0
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(4) Novoseek inferred chemical compound relationships for FBP1 Gene

Compound -log(P) Hits PubMed IDs
fructose-1,6-bisphosphate 70.5 4
leucovorin 44.9 2
folate 37.6 5
glucose 17.9 3
genes like me logo Genes that share compounds with FBP1: view

Transcripts for FBP1 Gene

Unigene Clusters for FBP1 Gene

Fructose-1,6-bisphosphatase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FBP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for FBP1 Gene

GeneLoc Exon Structure for
FBP1
ECgene alternative splicing isoforms for
FBP1

Expression for FBP1 Gene

mRNA expression in normal human tissues for FBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FBP1 Gene

This gene is overexpressed in Liver (22.2) and Kidney - Cortex (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FBP1 Gene

SOURCE GeneReport for Unigene cluster for FBP1 Gene Hs.494496

mRNA Expression by UniProt/SwissProt for FBP1 Gene

P09467-F16P1_HUMAN
Tissue specificity: Expressed in pancreatic islets.
genes like me logo Genes that share expressions with FBP1: view

In Situ Assay Products

Orthologs for FBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FBP1 35
  • 99.31 (n)
  • 99.11 (a)
FBP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FBP1 35
  • 85.11 (n)
  • 88.17 (a)
FBP1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FBP1 35
  • 87.18 (n)
  • 90.53 (a)
FBP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fbp1 35
  • 83.63 (n)
  • 84.91 (a)
Fbp1 16
Fbp1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fbp1 35
  • 83.83 (n)
  • 85.21 (a)
chicken
(Gallus gallus)
Aves FBP1 35
  • 74.36 (n)
  • 80.47 (a)
FBP1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FBP1 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fbp-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fbp1 35
  • 72.78 (n)
  • 82.25 (a)
MGC75708 35
zebrafish
(Danio rerio)
Actinopterygii fbp1a 35
  • 73.23 (n)
  • 80 (a)
fbp1a 36
  • 80 (a)
OneToMany
fbp1b 36
  • 80 (a)
OneToMany
wufk92h02 35
fruit fly
(Drosophila melanogaster)
Insecta fbp 36
  • 59 (a)
OneToMany
fbp 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea fbp-1 36
  • 59 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR593C 35
  • 57.34 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FBP1 35
  • 52.17 (n)
  • 48.45 (a)
FBP1 36
  • 43 (a)
OneToMany
FBP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E01211g 35
  • 52.73 (n)
  • 48.92 (a)
soybean
(Glycine max)
eudicotyledons Gma.2522 35
barley
(Hordeum vulgare)
Liliopsida Hv.5733 35
rice
(Oryza sativa)
Liliopsida Os.11756 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04797 35
  • 57.23 (n)
  • 46.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fbp1 35
  • 50.21 (n)
  • 45.99 (a)
Species with no ortholog for FBP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FBP1 Gene

ENSEMBL:
Gene Tree for FBP1 (if available)
TreeFam:
Gene Tree for FBP1 (if available)

Paralogs for FBP1 Gene

Paralogs for FBP1 Gene

Selected SIMAP similar genes for FBP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FBP1: view

Variants for FBP1 Gene

Sequence variations from dbSNP and Humsavar for FBP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs9695 -- 94,603,360(-) GCATC(C/T)GGAGA utr-variant-3-prime
rs547834 -- 94,602,938(-) GGCAG(A/T)GTGGG downstream-variant-500B
rs583365 -- 94,602,748(+) TGCAG(G/T)TACCA downstream-variant-500B
rs1042144 -- 94,606,869(-) TACGC(A/C/T)AGGGA synonymous-codon, reference
rs1042189 -- 94,603,255(-) TTTCC(A/C)CCATC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FBP1 Gene

Variant ID Type Subtype PubMed ID
nsv893596 CNV Gain 21882294
nsv466436 CNV Loss 19166990
esv2668617 CNV Deletion 23128226
nsv893597 CNV Gain 21882294
esv269321 CNV Insertion 20981092
esv274676 CNV Insertion 20981092
nsv415436 CNV Loss 16902084
esv2738800 CNV Deletion 23290073

Relevant External Links for FBP1 Gene

HapMap Linkage Disequilibrium report
FBP1
Human Gene Mutation Database (HGMD)
FBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FBP1 Gene

Disorders for FBP1 Gene

(1) OMIM Diseases for FBP1 Gene (611570)

UniProtKB/Swiss-Prot

F16P1_HUMAN
  • Fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:229700]: Inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children. {ECO:0000269 PubMed:12126934, ECO:0000269 PubMed:9382095}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for FBP1 Gene

(4) Novoseek inferred disease relationships for FBP1 Gene

Disease -log(P) Hits PubMed IDs
anemia hemolytic 35.9 1
hypoglycemia 30.9 1
hepatocellular carcinoma 17.3 1
tumors 0 5

Genatlas disease for FBP1 Gene

episodic spells of hyperventilation,apnea,hypoglycemia,metabolic acidosis and lactic acidosis with a risk of lethal course in the newborn

Relevant External Links for FBP1

Genetic Association Database (GAD)
FBP1
Human Genome Epidemiology (HuGE) Navigator
FBP1
genes like me logo Genes that share disorders with FBP1: view

Publications for FBP1 Gene

  1. Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency. (PMID: 7558035) El-Maghrabi M.R. … Pilkis S.J. (Genomics 1995) 3 4 23
  2. The estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples. (PMID: 18460190) Olsen L. … Werge T. (BMC Med. Genet. 2008) 3 23 48
  3. Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. (PMID: 16442285) von Geldern T.W. … Abad-Zapatero C. (Bioorg. Med. Chem. Lett. 2006) 3 4 23
  4. Isolation of a human liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of Asp-118 and Asp-121 in catalysis. (PMID: 8387495) El-Maghrabi M.R. … Pilkis S.J. (J. Biol. Chem. 1993) 2 3 4
  5. Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 2,6-bisphosphate, AMP, and Zn2+ at 2.0-A resolution: aspects of synergism between inhibitors. (PMID: 7809062) Xue Y. … Lipscomb W.N. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 25

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